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<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5IYG0</accession>
    <name>A0A8J5IYG0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G010565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5IYG0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="69" mass="7892" checksum="52E070F61696ACB0" modified="2022-05-25" version="1">MKRRKNRRMTEEEEEDEEEGEDREEEEQEDEVMGDDPDPDSDPGGDNPVETLTRDLTLVVIVEEEVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5IZ11</accession>
    <name>A0A8J5IZ11_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Smad nuclear-interacting protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Snip1-L</name>
        <name evidence="14" type="ORF">Hamer_G010721</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5IZ11"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000008">
        <property type="entry name" value="smad nuclear-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="FHA" evidence="13">
        <location>
            <begin position="358"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="141"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7153407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="474" mass="56770" checksum="1C7496B84F3D0617" modified="2022-05-25" version="1">MGKNRKEYHVDEMESYGYSSNTMDSSSSSSSSDSGSSDSENSNSSERERKKKHVKKKSSKLKKEKRIKRNTSAGSEEEEEAEYDERERRKRAKHSKHKSEADDRYMDEYETREERKHRSSRKHKHHHRKHKHKHRHHRRHRSEEQQERRREGSRDRSETRRGRDGEERKYKDRLEYEKPDRERRMDRETDRRDRREEKKHKERYESRQVKSKWDEEEDTQYDPNKRIKIESDEDEDEDDGRGQTNQRSEDDRRRHKTRKDDERGRQEVDSEQTSENGRPDWERVNNIKQDNSGAEEDRQKPNLGLSGKLTEDANTFNGVVIKYSQPPEARKPKRRWRWYIFKGEEDLPFLPLHRQSAYLIGRDRKVADIPTDHPSCSKQHAVLQYRLVSYNREDGTKGRTVKPYILDLESANGTYVNNRRIDPRRFVELLEKDVVKFGYSSREYILLHEGSKGDDENAPDTGVDLSPVSLLRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J7P3</accession>
    <name>A0A8J5J7P3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044824">
        <property type="protein sequence ID" value="KAG7154227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J7P3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="283" mass="32008" checksum="C36BF83B6E784609" modified="2022-05-25" version="1" fragment="single">MLLRQGGVVTLLLVFGVGWPGVVLMNSQGISGRLTAQEFIEMLQDGMLPSVTDKSPIHTARIVSYWFAAHPNIIILLWVPKSPDLNLIESLGSSVYLMQERLIYLLFLIAMQTKQQVNMQCLLQELEDIFADVPQPNPIVTHDVELIEGASPVKQAPYRVFPVNSTWKSKEKIVLHEVLEALKLSSDESNTSDEAQGKFESEKIQLQQEVVKKKEISKRMRETSWQEDSESGEVREETRQKKLGQKTCVGGNNNGNNRKEIVENGSRTEQSMEFEGSRQEHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J904</accession>
    <name>A0A8J5J904_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative BED zinc finger-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Hamer_G018512</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043933">
        <property type="protein sequence ID" value="KAG7154782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J904"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF109">
        <property type="entry name" value="FI07618P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="7">
        <location>
            <begin position="42"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="409"/>
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    </feature>
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            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
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            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
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        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7154782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="478" mass="52175" checksum="D70866A3F9903FA1" modified="2022-05-25" version="1">MDNESMSGSTSIPPDTVNLSTNTGVGGGVREMGSVGMSGSTRRTSRVWRYFGMVDNCHYICRLCSFVGAYTNTTNMRKHIQHHHPERFQDILDHTRPSTRPFYVGSIPRMRPPQHFTQQQTSPYPGGLVYPHTLPGLAAPEDHGSSDFSHNNGDEVPVAVSPELFLAESNERESTPAPPTPTPQKPESYQLRHNNHLTIVLEALARDESFMDVTLTAQGRSLKAHKVQGEMTVAAEDLTSLLKTAEILQVSGLAPSDSSATVNPHTESSTAGNARSSSASSSSSSSNLPSVSKTSRMVKTSTQQTTTPPARPKSRDSMINPTDFMDVDMTCVKEEVQSADEEESEEQVTKESSSQPPGGGMKGDQTLQHSLTTFSPSFDPDLEQPTASTSSSQDISPTTLPIKSDPETEINPLGTVGTEDPHPFMCPHCQEHHRDMDTMITHLRVRHPTKPSFTCGCGRVYTRQMLHQAHARMCSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JBM7</accession>
    <name>A0A8J5JBM7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041065">
        <property type="protein sequence ID" value="KAG7155637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JBM7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="93" mass="10276" checksum="1E77CF06AA66F843" modified="2022-05-25" version="1" fragment="single">MNGGLVQRLAELNLIRDPATVGTKTLVITRPRQHPVHQGESLGLVARPSVHRDESPAPVTKLSPHQDDGDTDQETDRLLGQQRSDDPGFYDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDJ6</accession>
    <name>A0A8J5JDJ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endo-1-4-beta-xylanase B-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xynB-L4</name>
        <name evidence="3" type="ORF">Hamer_G009478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="19"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="219"/>
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            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="297"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7153790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="553" mass="53133" checksum="31B1241C5DDAD733" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JE69</accession>
    <name>A0A8J5JE69_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043233">
        <property type="protein sequence ID" value="KAG7154991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JE69"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="202" mass="21983" checksum="B9A317254DD97D1B" modified="2022-05-25" version="1">MGRDKGVELPAPLQAAELLLSLQPPLEPGLYRRTGFHFRHWSGFTGGQGSTFGTDQGTTGGQGSSFGTGRGSTGGQGSTFGTGQIYRRTGFLSALIRALPEDRVPLLALVGIYRRTGFHFWHWSGIYRRTRFHFCTGRDLPEDKVPPSALVRSTGGQGSTFGTGGTNSVDDRVAPPDHGSCQAHVGHRHLRKSDFRVVTEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEW2</accession>
    <name>A0A8J5JEW2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium channel flower</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">flower-L</name>
        <name evidence="15" type="ORF">Hamer_G010668</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Homomultimer. Associates with the dally/ magu complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Presynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calcium channel flower family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEW2"/>
    <dbReference type="OrthoDB" id="9934994at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7153358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="162" mass="17418" checksum="AA29C161728BF46E" modified="2022-05-25" version="1">MATQAPQVDLPWWQKYLARGVGCGGGIIAMGLGVFNCVTITPWCIVAGIWQMLAAFIVISAEAPCCCMFIEFVQKYSIWVEGRPQWQKAVLYIVLSLPAIIMCPGLSTVFGSGLLFLCGVLYGMMALGKKGSREDMIAAAQNSTRQNSMKNSLVDGASPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFQ4</accession>
    <name>A0A8J5JFQ4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041673">
        <property type="protein sequence ID" value="KAG7155433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFQ4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="65" mass="7101" checksum="EC5C034BF3212948" modified="2022-05-25" version="1" fragment="single">DDDHKSSSGNLTHDAPETQVRNVVLNTGVPCCPRLCLLATALDFPVLACWLLPWTGFCLCCLIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFS5</accession>
    <name>A0A8J5JFS5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Zfp2-L</name>
        <name evidence="12" type="ORF">Hamer_G006477</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFS5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF15">
        <property type="entry name" value="REDUCED EXPRESSION 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7156511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="335" mass="37728" checksum="D4D72165482D5EBA" modified="2022-05-25" version="1">MRKITTMGHTKKKTFSCEKCGKEYRVLGCLKTHLKLCTIEDFECEECGEGFATQAALNVHKKAHTIRKCDECGEGFATQAALNVHKKAHTIHKCDECGEGFSRKAALSVHKKVHIIHECDECGDEFATQAALSVHEKVHIIHECDECGEEFAEKAALSVHKTVHNVHECYECGEEFPKKAALIVHKKVHNIHECDECGEEFAEKAALSVHKTVHNVHECYECGEEFPKKPALIVHKKVHNIYECYECGEEFAEKPALIVHKKVHNIHECDECGEEFAKKPALNVHKKVHNIHECDECGEEFAKKPALTVHKKVHSVHKMIPTANADGGPALESYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JG15</accession>
    <name>A0A8J5JG15_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Regulator of G-protein signaling loco-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">loco-L</name>
        <name evidence="8" type="ORF">Hamer_G009502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JG15"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01817">
        <property type="entry name" value="RBD1_RGS12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17067">
        <property type="entry name" value="RBD2_RGS12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000001">
        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003109">
        <property type="entry name" value="GoLoco_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003116">
        <property type="entry name" value="RBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046995">
        <property type="entry name" value="RGS10/12/14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024066">
        <property type="entry name" value="RGS_subdom1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45945">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING LOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45945:SF3">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING LOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02196">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00390">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00455">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50877">
        <property type="entry name" value="GOLOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50898">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RGS" evidence="6">
        <location>
            <begin position="228"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="RBD" evidence="7">
        <location>
            <begin position="470"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="RBD" evidence="7">
        <location>
            <begin position="541"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="351"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="663"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="858"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="900"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7153808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="990" mass="110528" checksum="DC4DD9ADEFAE49B0" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JG87</accession>
    <name>A0A8J5JG87_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tigger transposable element-derived protein 7-like 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TIGD7-L34</name>
        <name evidence="1" type="ORF">Hamer_G017704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046276">
        <property type="protein sequence ID" value="KAG7153883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JG87"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="132" mass="15283" checksum="A57C5FB5FAC22322" modified="2022-05-25" version="1">MYRRYKQELSTGLPIHGIVILSAAEHLAVHHNNHDFQASKGRSFKFWSRHRRVTHKIVGERLGADTTSVQPFREKLTALVKDNRLLLSQLYNGDTSDLVWKSLPNNIHISRLEAHVPDRKAVKNCIVMYQCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIR9</accession>
    <name>A0A8J5JIR9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Importin-11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Ipo11-L</name>
        <name evidence="3" type="ORF">Hamer_G011480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIR9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin-7/11-like TPR repeats" evidence="2">
        <location>
            <begin position="497"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="599" mass="68292" checksum="86860ADA201BACAC" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ64</accession>
    <name>A0A8J5JJ64_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monocarboxylate transporter 12-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G024184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042310">
        <property type="protein sequence ID" value="KAG7155263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJ64"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF251">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7155263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="513" mass="56964" checksum="327EBF37C69DFBBA" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJA3</accession>
    <name>A0A8J5JJA3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcium-activated chloride channel regulator 2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Clca2-L2</name>
        <name evidence="3" type="ORF">Hamer_G004147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJA3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="727" mass="78551" checksum="85E20DC31C1FF077" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJU2</accession>
    <name>A0A8J5JJU2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diacylglycerol kinase</fullName>
            <shortName evidence="7">DAG kinase</shortName>
            <ecNumber evidence="7">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Dgke-L</name>
        <name evidence="11" type="ORF">Hamer_G011300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="7"/>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJU2"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20801">
        <property type="entry name" value="C1_DGKepsilon_typeIII_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20853">
        <property type="entry name" value="C1_DGKepsilon_typeIII_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF118">
        <property type="entry name" value="DIACYLGLYCEROL KINASE EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="9">
        <location>
            <begin position="104"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="10">
        <location>
            <begin position="192"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7158641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="521" mass="58647" checksum="A7FBBF8C12AA1CE7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKB8</accession>
    <name>A0A8J5JKB8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rho GTPase-activating protein 29-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">arhgap29-L</name>
        <name evidence="9" type="ORF">Hamer_G018745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036987">
        <property type="protein sequence ID" value="KAG7157683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKB8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20816">
        <property type="entry name" value="C1_GMIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054713">
        <property type="entry name" value="GMIP/FCHO2-like_FCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22699">
        <property type="entry name" value="GMIP-like_FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="F-BAR" evidence="8">
        <location>
            <begin position="149"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="7">
        <location>
            <begin position="476"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="693"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="816"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1200"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="734"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="755"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="830"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="860"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="959"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1016"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1053"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1071"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1200"/>
            <end position="1212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7157683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1272" mass="138871" checksum="96815BE459DBAB0F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKD8</accession>
    <name>A0A8J5JKD8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037407">
        <property type="protein sequence ID" value="KAG7157514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKD8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="214" mass="24446" checksum="87A35BBB1FF0C9C0" modified="2022-05-25" version="1" fragment="single">VAARNSGRAQQLSEVAANDNHKELINDMIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVSELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELRQDVYHFFDSSSDEQEATSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKK3</accession>
    <name>A0A8J5JKK3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pro-resilin-like 63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G016516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKK3"/>
    <dbReference type="OrthoDB" id="6382835at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035159746" evidence="3">
        <location>
            <begin position="18"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7159136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="120" mass="13070" checksum="ECBAF8383796C104" modified="2022-05-25" version="1">MALKVYLLAALVAVTVADTIPYTPPRPSYTAPAPSGPAQYNFDWSVNDGNSGNNYGHNEGRNGYNTEGAYYVQLPDGRLQRVTYTVNGDSGFVAQVEYEGEAQYSAYQPSPSYRPTPSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKL0</accession>
    <name>A0A8J5JKL0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pro-resilin-like 74</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G016531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKL0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035243859" evidence="4">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7159151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="127" mass="14200" checksum="D1C258428CDB2662" modified="2022-05-25" version="1">MSQIIVLAALVVVTLARPDYVPPSPVVSLHVFPKYAGDPPRYDFNYAVKDYNGNDFGHQESRDGYNTEGNYYVQLPDGRLERVNYYVNGDSGFVAQVEYEGEAQYPAYQPSPSYGPSPSYQPEPSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLV4</accession>
    <name>A0A8J5JLV4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Chst12-L</name>
        <name evidence="10" type="ORF">Hamer_G022570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010035183">
        <property type="protein sequence ID" value="KAG7158411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLV4"/>
    <dbReference type="OrthoDB" id="6344560at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7158411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="368" mass="42716" checksum="3DC54F52061031F7" modified="2022-05-25" version="1">MTFLKNIIYFLVGGTAISLVIVRVLDDQIKSAVSWTSSGESAGQMMRERAEHLVQECRRRQVKEFVPTRPVMVNRYTLSSPFPVCIPPKCGSTAWGFFMRQLRHIIPGSREHMKTLVVRHPFVRLASAYREKYLNGSPLNTRSKTGGRQPSQYVWVNYWIPALIHKRLITPSPKFLRRLEKTSKAFRFVAKKAGDTLDRFRVDTSLNVDSSHMTMRIKSVREKVNRGLQEELGAAVHAGYSEVQRSKLQESFNNASISLVEFLRYVLWTWDMGIEDRHWTPINELCDACGANYTYVLHMENREEPSYLFGLLQLQVTLPEVYKSRSLSTYQSDLRNFENLPRDLLARLVDMYELDFQLFGYDKQPFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMN3</accession>
    <name>A0A8J5JMN3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMN3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="135" mass="15004" checksum="3F325C22C4110C3C" modified="2022-05-25" version="1">MGDADHVQSSAGRRSHTLSYRPTHHLHHTITALRTLQHNNRCNTTCHQPMCNELQHTTLLNYQENLRLAGQVVATRPAIQGVIGQRVVLPESSRNMVGRAVVSTLSPVPLATADITPRGHHHSNTRKQITTCKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNB0</accession>
    <name>A0A8J5JNB0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G019685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029207">
        <property type="protein sequence ID" value="KAG7161492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNB0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="65" mass="7271" checksum="F906A4A129CB908B" modified="2022-05-25" version="1">MSTMGLADVAIRNENFCVYSLAEKCILPLVKTEGPSTHVRDLLTHKFSHSPNLEKLAQAIRKAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNS7</accession>
    <name>A0A8J5JNS7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor capicua-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cic-L2</name>
        <name evidence="8" type="ORF">Hamer_G027712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029785">
        <property type="protein sequence ID" value="KAG7161145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNS7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052412">
        <property type="entry name" value="CC-Dev_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058606">
        <property type="entry name" value="HTH_Cic_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059">
        <property type="entry name" value="HMG-BOX TRANSCRIPTION FACTOR BBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059:SF13">
        <property type="entry name" value="PROTEIN CAPICUA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25981">
        <property type="entry name" value="HTH_Cic_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Protein capicua homolog-like C-terminal tri-helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7161145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="334" mass="36335" checksum="2BFA012C653D318E" modified="2022-05-25" version="1" fragment="single">GSLAAITLPMQQLSPSQQLQQQQQQQVQQQQQQQQQQQQQQQQQQQKVKAQVASIPVAVPGGRPLDDEELDDKPKFILAPTPAQLGKAPRQKRLNSSGQISSIGDTAPQLSPDVKMAPPHHPSGDSKVSPVLSNASEGDSSVQTTTQQMVSVPPSPSEKKSFFKKNIEDGMDKVLEEVNFEQKFGALPEFNPDEVQSPSVNASTGPSVPSSPRTFITSYRKKRKHSSGEESGSDTPMSVTPHQTPSLTPSSTLQGSKFFPPDFNPETFKGGRSPKTPRDADKSHSSLRHILDQRRTLVMQLFTEYGWFPSGTRSSLTAAVSTSNQATTSLPVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNZ5</accession>
    <name>A0A8J5JNZ5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033826">
        <property type="protein sequence ID" value="KAG7159100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNZ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="9876" checksum="7EBBB35B58D15880" modified="2022-05-25" version="1">MTLIECHYDNRGDLDKPREEYAGCETDQPICIKEDLSPGTCLSPLHVCRSKYIYSFTPPVLQYKNYVISDIGEKICVYIYDLDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JP85</accession>
    <name>A0A8J5JP85_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Actin-like 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Act-L34</name>
        <name evidence="13" type="ORF">Hamer_G006707</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JP85"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0558">Oxidation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7156714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="393" mass="43794" checksum="10084B62224EBBB9" modified="2022-05-25" version="1">MIQTRELRPDPTKHHSTMCDDDVSPLVVDNGSGMVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRIAPEESPVLLTEAPLNPKANREKMTQIMFETFATPAMYVAIQAVLSLYASGRTTGIVLDTGDGVTHTVPIYEGYCLPHAILRLDLAGRDLTAYLTKIMTERGYSFTTTAEREIVRDIKEKLCYVALDFENEMNIAAASASLEKSYELPDGQVITIGNERFRCPESLFQPSFLGMESVGIHETVYNSIMRCDIDIRKDLFANNVLSGGTTMYPGIADRMQKEITALAPPTIKIKIIAPPERKYSVWIGGSILASLSTFQTMWITKEEYDESGPGIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQP4</accession>
    <name>A0A8J5JQP4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033882">
        <property type="protein sequence ID" value="KAG7159088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQP4"/>
    <dbReference type="OrthoDB" id="204305at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="347" mass="39907" checksum="DA8F71877F4F3B03" modified="2022-05-25" version="1">MGEAGVRLRLVWVCLAACIFVIASYTHHTTLAPTTLQPSLLEVHPPNDSFIPWWESGRCTCEEKVCVPDVDVPFDPLDGVGGTCGRRAWEAGDGQHVLSFSLYGDKRNYWRGLDSLLKKVRRLYPGWKVRVYTNPRFYVSTLCPLLHQHDHLYLCDVTNLPQPLGNLTGIHRMMWRVVPLGDPQLRALMIRDTDSAISRREAAAVREWLASSKHFHVMRDHPAHNAPIMGGLWGARWGLNRQLVPENAKFLSQIRDKMFKDAYGEQKHGKDQEILAVRLWPKMAGNVMAHDSYWCKFYGKAWPWPTKRENRYFVGSTSYRDPPGNTKVPKPCPVRCRPPEHHDWIYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRJ3</accession>
    <name>A0A8J5JRJ3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Still life-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sif-L2</name>
        <name evidence="3" type="ORF">Hamer_G001953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7162932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRJ3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01255">
        <property type="entry name" value="PH2_Tiam1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055230">
        <property type="entry name" value="PH_Tiam1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043537">
        <property type="entry name" value="Tiam1/Tiam2/Sif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001:SF3">
        <property type="entry name" value="PROTEIN STILL LIFE, ISOFORM SIF TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001">
        <property type="entry name" value="TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23014">
        <property type="entry name" value="PH_Tiam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tiam1/2 second PH-like" evidence="2">
        <location>
            <begin position="18"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7162932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="341" mass="38289" checksum="87B12C8A87D0D3DD" modified="2022-05-25" version="1" fragment="single">MEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPVDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKTAVVFLCKERLRQKKKLMGAPGKNSSSEVEIIRYQVLIPVTEVQVRASAMKDMDSHFLWELIHLKSQLQRRSEKVYHLSNSTSEFRNAFLKTIRQIIRESVRNMNIPANKPSSSSSSLSSKGNTNTLQPSRSAPKKKSPIVQSATLQRHSAGNIDYDNLESYDNVPETQLGHDQNNFRTRSKTVSDGMDELSDSTTKSDGGKDELGTRSEGEEEVIDKKKATLGRTPNHLSLSTTSTLSTGSTGSMAKLIQASNQPAQYQPTRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRL2</accession>
    <name>A0A8J5JRL2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Cks1b-L2</name>
        <name evidence="6" type="ORF">Hamer_G023490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030714">
        <property type="protein sequence ID" value="KAG7160788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRL2"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000001">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00944">
        <property type="entry name" value="CKS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7160788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="86" mass="10528" checksum="3F7FCE2C769C2122" modified="2022-05-25" version="1">MPHRIYYSDKYYDEKFEYRHVMLPKDLSKLVPKTHLMSESEWRSLGVQQSQGWVHYMIHEPEPHILLFRRPITTPPPKMDEEDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRM3</accession>
    <name>A0A8J5JRM3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRM3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="136" mass="15311" checksum="77C26EE15E1F263F" modified="2022-05-25" version="1">MVKSPERNACTGSDEDENSEENEEDVRDRISIDRSIALTTELLAGLEQRSFVSDQEIMNVFLLQDKLIRERPKYMKQQILPDIFKKIARKQEEAIAVSTLHNPLPSTSRQVEAVPVAEDVVTVSDKDDNPDSPSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSB0</accession>
    <name>A0A8J5JSB0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Keratin, high-sulfur matrix protein, B2D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Krb2d-L</name>
        <name evidence="1" type="ORF">Hamer_G004462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSB0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="138" mass="14603" checksum="77A0F7A63E4EED31" modified="2022-05-25" version="1" fragment="single">VLCCLPVSHQVCCLPVPHQVLCCLPVSHQVLCCLPVSHQVLCCLPVSHQVLCCLPVSHQVLCCLPVSHQCCLLTCLSPGVVLLTCLSPGVVLLTCLSPGVVLYLSLTRCCVAYLSLSPGVVLLPVLTRCCVAYLSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSE8</accession>
    <name>A0A8J5JSE8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nephrin-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Nphs1-L3</name>
        <name evidence="5" type="ORF">Hamer_G004441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSE8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="103"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="199"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7163317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="607" mass="66164" checksum="69E1C886271A8389" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTI5</accession>
    <name>A0A8J5JTI5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone H2A-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">H2A-L3</name>
        <name evidence="10" type="ORF">Hamer_G010843</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTI5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02904">
        <property type="entry name" value="Macro_H2A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.220.10:FF:000002">
        <property type="entry name" value="Core histone macro-H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035796">
        <property type="entry name" value="Macro_H2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="143"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7162176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="328" mass="34311" checksum="4F6343BFB669EB57" modified="2022-05-25" version="1">MKAGPGTRKLRIGVGAPVYAAALLRNVTIASGGVLPKIHPELLAKKKGGKFVTGGNTPVTVPYKKPIATKPPAHKKMTTTKMNGNVSGATAASNTTTTMANAMSLPKSPNSATNVTSGSASPLKLRAKGKDMAPVQLPSGTFTVLSEKKLFLGQKLTVVQSDISTVTADAVVHPTNSNLDFLGQVGQALSKAGGKELVQEVRDLANCNGALPSCDVAVCNGCKLPARWVIHVNGPTNGDVDAFDKLERCVRNCLVLADTRNLKSLALPSIGSGAAGFPKQQAAQTIIKSICNYFVNVMSSSLKQIYFVLYDMESIGAYTAELAKLDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JU59</accession>
    <name>A0A8J5JU59_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030308">
        <property type="protein sequence ID" value="KAG7161038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JU59"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035275911" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27921" checksum="D4B5FA4380E6B2E7" modified="2022-05-25" version="1">MCYHGAGSWMMVVVLLLVGVRPPHSRVMMDAASQMVQSEIYGDFMVVMNTKVDDSSTLYTVSLPSLCNCVTACWTTNLCDSASFQTLAAGGECRLSTTGPSKTVVVSDEDARYVYWLESVNGKTWVGSDGLLYLALSQSKIFNAAAACESIPGARLGVYTTSESYQDLKKYNDQIPWNERICVDLKKVNNILTWGDGTPYSSTESLSPFNYVSPFNYFSDWTAAYHTLQGDTFHDQNWGECWVLCQSNVTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVB8</accession>
    <name>A0A8J5JVB8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Deubiquitinase OTUD6B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">otud6b-L</name>
        <name evidence="4" type="ORF">Hamer_G002124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVB8"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22761">
        <property type="entry name" value="OTU_OTUD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049772">
        <property type="entry name" value="OTU_OTUD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="3">
        <location>
            <begin position="162"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7163061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="306" mass="34834" checksum="BC1DA64CFB714668" modified="2022-05-25" version="1">MADETNGALLIEEELVATHRREKKELQACIQQLKKSANKDKKKKKEASDEIARMEKDLQDKHTQELAALKTSQQEVNVVSNGVDSLTLTDEDPGEPEEVDGDIECSQPGGKKLSKAEKRRQKKAEAIREREARIKEEEANNKYSARNIEAEKLKLLLRERKLKMHEIKPDGNCMYTAIAHQMEGNTTVPWLRLQAGQFIRQNNEAFAPFITDPKTGELLTLTQFADYCFQIENTPAWGGQPELRALSQVLQRKIEVLQAEGSPVIFGEEYTDKKTILLAYYRHYYGLGEHYNSVTALTPTAEEESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JX12</accession>
    <name>A0A8J5JX12_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 585B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Znf585B-L</name>
        <name evidence="12" type="ORF">Hamer_G011823</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7165915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JX12"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001967">
        <property type="entry name" value="Ras-responsive element-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000130">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002402">
        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7165915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="296" mass="33439" checksum="05215CD5E4F07E86" modified="2022-05-25" version="1" fragment="single">VRSTSLMSRPSSSSQPSCPALPAAHPRPYQPLPTSSLPELSSLTRSHSCPFCSKKFYGSVDLERHKRTHTGEKPFACNFCSYRATQLGNLQRHINSSWSHLGQDFLACSSSETHPAFISPQMSARLVPPPLGSPHTKLYQCPLCPKSYDYRGSFDIHMRTHTGDTPFACPHCPLRTKDKNAEKYTFIAVWPRGWGDSDCLTSVSRSQEHPSTDKHLVCPDCKKPFAQKSDLERHYRIHTGEKPFACSICPYRATVKTSLQKHLRMHSGEKPYACPFCPLRSSDKSNLMRHIRSKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JX61</accession>
    <name>A0A8J5JX61_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">A-kinase anchor protein 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Akap10-L</name>
        <name evidence="3" type="ORF">Hamer_G011121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JX61"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051018">
        <property type="term" value="F:protein kinase A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12804">
        <property type="entry name" value="AKAP10_AKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08721">
        <property type="entry name" value="RGS_AKAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000005">
        <property type="entry name" value="Putative A-kinase anchor protein 10 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037719">
        <property type="entry name" value="AKAP10_AKB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="175"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="369"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="461"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="764" mass="85498" checksum="A64C411B468158A6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXR7</accession>
    <name>A0A8J5JXR7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXR7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="451" mass="50248" checksum="D35AD8F2F3AC3941" modified="2022-05-25" version="1">MEESESQSGENAKGTVRPTSSTTRSATEIYLVGQPASSIRGSKLPTMRQVLKFFFHTVNESGDRQETFKETVRNVLTFWNLARIKTISERGCREKLTRLWEHWRSLQKSRDRAAKDKVENFKSQLDLLWDIGAPDAVEDIEKNRLLTPADKQQDIAFYQDQRGERKAFMSGNDKIFAAKKRKQEERVEKQRSKQGRFAACEPSSSDSRPQTSVVADTPTEVEMEKKDTAIQPGRYTSKHPYVTVQLPRRILQEPALKELADRLRISNNEIVSVVAAVLRSANPPGDLSEFRISRETARRARASHLRQVAAAQREAFTPPPHAVVHWDGKLVKNVVGEEEHRQAIFISGRGHEEGKLLAVLPVKDGTGLTQARATARAIEDWSCASNVKALCFDTTSSNTGRVQGCPSGGAAGKTAVEAWVQTPRHGTGGESLCQQHLRQNIGPYGPSLPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXT1</accession>
    <name>A0A8J5JXT1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative CD80-like C2-set immunoglobulin domain-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G026491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023285">
        <property type="protein sequence ID" value="KAG7165837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXT1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF15">
        <property type="entry name" value="BEATEN PATH IIIA, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="CD80-like immunoglobulin C2-set" evidence="3">
        <location>
            <begin position="26"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7165837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="151" mass="16400" checksum="FB242CC9EB6162D9" modified="2022-05-25" version="1">MFNNLTVVVMPEVPVLTGLQGRYRVGDTLNITCTARDARPPAILSFYVNGKLIHPGSGRVQELATTEGTYYGVYNTRSRLILPLSERHVPTITLECQGWVLTLETQIAATMEVNTARAFTSYFNTGAGTVVPCLASVLLIVAITHLLTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZB0</accession>
    <name>A0A8J5JZB0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G011218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZB0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="205" mass="23669" checksum="077CC3B2D4C90260" modified="2022-05-25" version="1">MLLSSGAISYRFLGRNPTVFLGGFLPFSRAEFYRLWGRNPTVFWAKCYCLLGLYPTVLGGGILPLYRAKSQHLLGRNPTVFWRRILPFSVTESYHILGQNPTVSWGGIIPYSEAKFYRLLGQNLTAFWAEFYPILRRKPILIWDRILPYFGWNHTLFWGGILPNSERETYPILGRALPFSGEGSYHLPAQKPTVFWRRILPYSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZH7</accession>
    <name>A0A8J5JZH7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Transposable element Tc1 transposase-like 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tc1a-L27</name>
        <name evidence="2" type="ORF">Hamer_G003468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZH7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="139" mass="15468" checksum="0C758CCFD631B9E0" modified="2022-05-25" version="1">MSTMQQRLTTCGQIIALREEGLMVRAIADRLAVSTSTLERWIRRYAETERRPRPRLTTGDEDAAIIAAIRNNPFSNPVAIREALHLDRAQTARSRLHEVSIQQRVPAIKERLTDQHRTGRLPAICGGGPGVLVASNLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0H4</accession>
    <name>A0A8J5K0H4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 35 member F5-like 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Hamer_G030077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021196">
        <property type="protein sequence ID" value="KAG7167895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0H4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035174487" evidence="6">
        <location>
            <begin position="27"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7167895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="257" mass="29158" checksum="F97A2FB6859BEA72" modified="2022-05-25" version="1">MMGRGRRLALGIFVLLVVDVIWVASSELSEYIFNDTGFNKPFFSTYLKTSMFSLYLLGFIFWSPWRHQCAQRNHNESIYQTRDRRTPPPVPIFTLDQLASSVARDSDANAQLTHLSEPKYVPLKLQELQEKSSDGESDDSSVKSVRFSKLTEVRQMSENEAVDAMMSRLSFSASVRAEQLAMQAANKLSVKEVMKISSIFCLLVFVSLEDLNLESSVVPVGVVWSIAGAILYACYMVFLKHKVPTEDRMDFTMFFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1P5</accession>
    <name>A0A8J5K1P5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-binding cassette sub-family G member 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Abcg5-L</name>
        <name evidence="9" type="ORF">Hamer_G024533</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023447">
        <property type="protein sequence ID" value="KAG7165809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1P5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001473">
        <property type="entry name" value="ATP-binding cassette transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF113">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="596"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="49"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7165809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="632" mass="71263" checksum="C580C2A473C7F008" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K225</accession>
    <name>A0A8J5K225_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adhesion G protein-coupled receptor L3-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Adgrl3-L1</name>
        <name evidence="8" type="ORF">Hamer_G004917</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    </dbReference>
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            <begin position="21"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="741"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="783"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="831"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="937"/>
        </location>
    </feature>
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            <end position="963"/>
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            <end position="967"/>
        </location>
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            <end position="141"/>
        </location>
    </feature>
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        <location>
            <begin position="160"/>
            <end position="224"/>
        </location>
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            <end position="896"/>
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            <begin position="985"/>
            <end position="1044"/>
        </location>
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        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
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        <location>
            <begin position="869"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <end position="896"/>
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        <location>
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            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1025"/>
            <end position="1037"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7165133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1044" mass="117990" checksum="069E98DDFC23756D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2J5</accession>
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        <submittedName>
            <fullName evidence="9">Glutamate-gated chloride channel-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GluCa-L10</name>
        <name evidence="9" type="ORF">Hamer_G018471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
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        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
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        </lineage>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </feature>
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        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7168031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="839" mass="95708" checksum="98CAA8037FECB287" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2S9</accession>
    <name>A0A8J5K2S9_HOMAM</name>
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        <submittedName>
            <fullName evidence="7">Delta-like protein 4-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="primary">Dll4-L</name>
        <name evidence="7" type="ORF">Hamer_G020830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026066">
        <property type="protein sequence ID" value="KAG7163914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2S9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011651">
        <property type="entry name" value="Notch_ligand_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07657">
        <property type="entry name" value="MNNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Notch ligand N-terminal" evidence="6">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7163914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="187" mass="20231" checksum="8FDFE7D7BAD4702E" modified="2022-05-25" version="1" fragment="single">VPSLLVCVLQGRAWAGGGKGVLRVRVTSFRNDLSRDVDGECCLNPRGLPGCSSHCRTFFRVCATHPGRRQPPTSITTAARNLSSILADATHAHTRPHSPSPMPHALRVGGRGWGRRSRHVRGSTGRGGATPQVPYRVGQLIARHVGHHRVEGGRAWSHHAHTNAHTTLNYSLKVICATPYQGSHCSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K300</accession>
    <name>A0A8J5K300_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeobox protein Hox-C4a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Hoxc4a-L</name>
        <name evidence="7" type="ORF">Hamer_G005649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022531">
        <property type="protein sequence ID" value="KAG7166533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K300"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050609">
        <property type="entry name" value="Antp_homeobox_Deformed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771">
        <property type="entry name" value="HOMEOTIC PROTEIN DEFORMED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771:SF6">
        <property type="entry name" value="HOMEOTIC PROTEIN SEX COMBS REDUCED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7166533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="224" mass="24361" checksum="4C801309B9A375F6" modified="2022-05-25" version="1">MTMSSFLMNSGPYVDPKFPPPEEYSQNSYIPPQSDYYNPAQHYPYHGMHQAGMQYGRDAMQYNHAGYYQQACVMPQHQPMAAHISPQIAPCHSPLQQHQVPPRSPVASPDPSAGGTGGGGSMGAQMAQHMGAGGVEGSPEETVTELDANGQPVIYPWMKKIHVAGSAVSTSRVLATLKEGFSNYQRAVRRITSRVGRHTSWPQLPHGLSPLGNKSIRYCAGKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K322</accession>
    <name>A0A8J5K322_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Armadillo repeat-containing protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Armc6-L</name>
        <name evidence="3" type="ORF">Hamer_G021509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019984">
        <property type="protein sequence ID" value="KAG7168597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K322"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="123"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7168597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="397" mass="43619" checksum="116EB8C976B36DBE" modified="2022-05-25" version="1">MAKVVYQETFDSVVLENVTEFDSPLDEAIDEAIKEFEAQGVHLGIIVKNMRLSEDKKTIVHDILIALEKLRNAADGSPVLEDIQGPLTTFSAQCKVSIAHRARWSTECCLKHEVNRQNLVAAGALGSLVALLQAQKSNSRVVKATSKALRAYTLDDDIRQAFGKAHEHARLLAEEHGLIAISLDMIKDWLQDSDTASELLSTVGKLCVRAEYCQEIVDHGALHVINNVFVSFPDHPAINKQAMSLLKAMVGNDKVKTEAMKSGVSQLIIAAIIKHQAVVGVCEEGFGALSMLALRVPAHAKQIIQAGGGQAIIQAMKIHYNNMQLQKLGCMAIRNIGCRVPENRQLFIEYGVEEVINSALQNHGEPIKDVAKAALRDLDLKVDFVEQWRGTGHEICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K346</accession>
    <name>A0A8J5K346_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-lipopolysaccharide factor-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ALF-L9</name>
        <name evidence="2" type="ORF">Hamer_G025732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025985">
        <property type="protein sequence ID" value="KAG7164049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K346"/>
    <dbReference type="OrthoDB" id="6356274at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024509">
        <property type="entry name" value="Anti-LPS_factor/Scygonadin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11630">
        <property type="entry name" value="Anti-LPS-SCYG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="155" mass="17321" checksum="BD0A49342EE77414" modified="2022-05-25" version="1">MVIIASSASPSGSFHLREPGSVSKVSGSSVSSVRLLLLVFVWGVALLLVPTPTTAKPFDISEFFAQMITHVADKSFADGELDLLDHFCSYNIRPYFHKWRLYYRSQVWCPGWSPIIGTADRHTNSVHAKMAATRSFVHQAVDRGLVRKEEAVNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K392</accession>
    <name>A0A8J5K392_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Period circadian protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Hamer_G011066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K392"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022728">
        <property type="entry name" value="Period_circadian-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050760">
        <property type="entry name" value="Period_circadian_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269:SF16">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12114">
        <property type="entry name" value="Period_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Period circadian-like C-terminal" evidence="7">
        <location>
            <begin position="83"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7166240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="310" mass="34721" checksum="C6791C15575F9140" modified="2022-05-25" version="1">MSAIPGVMYQTVAPPLFNAPPLITATSNVPPLTCAHQTPRLRQLKQNQDRREAAPLASGKIISSHSHIDESIRSYDSEMNRDSSQVSQFSQSTSVRAEAESIGSPGKQDRLAADDREQHHENSSDMVLSGTSSPSSLREYKSTDDSMQNISENSENSEATTSGMKWNTPRSKCQRPVLNDPPWLEDVKVTPELLYKYQMETKELVDVLRQDMDMLKRLRQPAWVDDQLSSLYNELELEGSSTDLHLEEGITSSSGEDQARTSFQTSPRKKKSSTYFSKMAMLHEEDAPMPPSDLWTERQHQAHDTSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3G5</accession>
    <name>A0A8J5K3G5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G021493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019984">
        <property type="protein sequence ID" value="KAG7168586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3G5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="149" mass="17758" checksum="941D5E1A98DF8367" modified="2022-05-25" version="1">MDAYSLAELAVLLWIQRLKHKRRTRIWMHELNTKGPNFGSFSHLFPDLVNHQDKFYNFFRMTVENFKKLVDLTGSSRRKMTTNYRRAAITSRSRWLRSVGSYIAGRSRTKFIRTITYDNDYPDILENLPDADFPDINLDFLQTNFMKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3L9</accession>
    <name>A0A8J5K3L9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoglucanase</fullName>
            <ecNumber evidence="9">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">celD-L15</name>
        <name evidence="11" type="ORF">Hamer_G020627</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010014925">
        <property type="protein sequence ID" value="KAG7169952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3L9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033126">
        <property type="entry name" value="Glyco_hydro_9_Asp/Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00698">
        <property type="entry name" value="GH9_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="10">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7169952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="229" mass="25525" checksum="C9D331E30CFA9129" modified="2022-05-25" version="1" fragment="single">SWSGYGDELVWGALWLARATGDDAYLDRARDRWNEFDLLAEDVKQFSWDDKRAGVFELFILLDGSEEFSTQLLKYLDFLKNKADYTPEGLVFLDQWGSNRHAANVAFISLWAAKNGIDKEANEEWARGQVGQLLGDNSRYEMSFVVGYGEKYPERPHHRSSSCPTPPETCEGALTNPGPNPHVLYGALVGGPAASGAYEDNRQDYQHNEVACDYNAAYTGALAALIEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4H7</accession>
    <name>A0A8J5K4H7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 536-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Znf536-L9</name>
        <name evidence="10" type="ORF">Hamer_G012833</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4H7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7167384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="172" mass="19012" checksum="80F89CE06256C762" modified="2022-05-25" version="1">MQLVLLLEPPYILQGRAAPLQEGSGSTGGSGVRSVALLSCPNCPKTFTGPGRHQLYERHVIVHTGERPFNCPHCTYRANQLSNLRRHIKSIHQPPNQSGNNPLQGQHYGNATHQAHVSRGISQQVAVALMPHNQNLSSRSFEEQRFTTNSSSSFQHQFNRENFEGGGGLPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5Y5</accession>
    <name>A0A8J5K5Y5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5Y5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="59" mass="7066" checksum="2211ED6425380C83" modified="2022-05-25" version="1">MLEHLNVNSVKKGKRRRGRRRREEEEGEEKEGERWMSNDNDDDDDDDDDDDDDDADDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6K0</accession>
    <name>A0A8J5K6K0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G018948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014098">
        <property type="protein sequence ID" value="KAG7170461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6K0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035223587" evidence="2">
        <location>
            <begin position="19"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="386" mass="42871" checksum="43797A94D1A50254" modified="2022-05-25" version="1" fragment="single">TRMRWVVVVLLLPTLTLALSRHPHPPQPVNILNIQPNYILSSSTHKESNSANHINYLKHEDLSPQAMLQQESKMLSSLLKILPSQFTIKLNVKSPLSTQGVVRVNAESTHTSLSENTQTPLLSFTTTNKTGYFAFTVTSSHKPAHTQPSSTLPPPPTAKTLHKHNTEDKNLRHSVVHETEVTLGADSVNLGVTRERYNVTTATVSLYTPCLNLPVGWLLVLAVLCCLTRTHLGKKLLRTLGLHPHLDHHPDPELGHGMGNIDGSPGMRRSVEDTGENMMEMEEEDNVADEEGGQVTEADIEGDKTDTYIMEDVDLSVTNVNTDKTVVKKITGPLSHPGGRFSLTVWITLFFHHVNNMTTVFIHHVNIMTTVFIHHVNNMTNVFTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K910</accession>
    <name>A0A8J5K910_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine-protein kinase Lck-like 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Tyrosine-protein kinase Lck-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Lck-L3</name>
        <name evidence="6" type="synonym">Lck-L4</name>
        <name evidence="5" type="ORF">Hamer_G029062</name>
        <name evidence="6" type="ORF">Hamer_G029158</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019644">
        <property type="protein sequence ID" value="KAG7168673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010016265">
        <property type="protein sequence ID" value="KAG7169496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K910"/>
    <dbReference type="OrthoDB" id="6128227at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7168673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7169496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="186" mass="20186" checksum="878E22E02EE0371E" modified="2022-05-25" version="1">MTSPVQLNNISHNSSSSTTSTSGGTDLPQLTWDSLRLVRNVGAGAFGVSHHGQLTLGNGDVTEVVVKILHTGKANTKEARVLHELAGAGGAPLLYGVTTEPHAIVMQYCQGVRLDSFLSCFKYDVHHRQKAYDATRVALAEFHAAGYAHMDLHAFNIIIDTSTSPYTCHLIDVGISERIWPNDDWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KD88</accession>
    <name>A0A8J5KD88_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015662">
        <property type="protein sequence ID" value="KAG7169603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KD88"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="342" mass="38731" checksum="83AD393273A73F62" modified="2022-05-25" version="1">MEESESQSGENAKGTVRPTSSTTRSATEIYLVGQPASSIRGSKLPTMRQVLKFFFHTVNESGDRQETLKETVRNVLTFWNLARIKTISERGCREKLTRLWEHWRSLQKSRDRAAKDKVENFKSQLDLLWDIGAPDAVEDIEKNRLLTPADKQQDIAFYQDQRGERKAFMSGNDKIFAAKKRKQEERVEKQRSKQGRFAACEPSSSDSRPQTSVVADTPTEVEMEKKDTAIQPGRYTSKHPYVTVQLPRRILQEPALKELADRLRISNNEVAAAQREAFTPPPHAVVHWDGKLVKNVVGEEEHRQAIFISGRGHEEGKLLAVLPVKDGTGLTQARATARAIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5KDU5_HOMAM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">Hamer_G013444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KDU5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7170628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="62" mass="7337" checksum="D7066BF0B32A5F1D" modified="2022-05-25" version="1" fragment="single">MKANKGNNNIDLQRWATNKIQMRRECFPIKTKKVTLTVMMTFFEPQTGKEKMTELKVCVEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KHU1</accession>
    <name>A0A8J5KHU1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018069">
        <property type="protein sequence ID" value="KAG7169179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KHU1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="105" mass="11558" checksum="862B42FF362D68F2" modified="2022-05-25" version="1">MSLGGRPPRTMLIFKRGAPFFDTLVTPENLSPGHCSIIVGFLDYFIGLCTIFSESEANSDGAALLDTSLRVEWRLTPLSRWAGVHTHAKMHYGRSAPQILAKLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KJH7</accession>
    <name>A0A8J5KJH7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ras-associating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KJH7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RA_dom"/>
    </dbReference>
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        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="1">
        <location>
            <begin position="207"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="546" mass="64519" checksum="59505F7B553A22BD" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KPB3</accession>
    <name>A0A8J5KPB3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KPB3"/>
    <dbReference type="OrthoDB" id="6357413at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="34409" checksum="62BC83A7914576C5" modified="2022-05-25" version="1">MPNATNEVTDVLIKRGFKRAAIVGMATGSSTVFEGVVTMAVDGSSTAAAVVGSTLILIGVMLTVVSAVGYKRYTKYRSRQVGAVMARARRMARGEGASPAFLDLGSGGELLRVMAACDNTVTICDTVVPLEAYCNGKICEVNMGEITTNSGRSGSVDNLATRISRKSASVDTLATTNSRKSGSVDNLADLRTIDISPGMIVLPVYLVESSCTVNVYMPDEHEAPLWLYTDMLMLFWVAVFLASIGHTFLNAAFIILGVAFNSLPNVTIDILCGVFGCIGGVCIVAAGAVACRCYKVYHKYLRESAPSPFEETTLTNGPAIWQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MG75</accession>
    <name>A0A8J5MG75_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulation of nuclear pre-mRNA domain-containing protein 1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Rprd1a-L</name>
        <name evidence="4" type="ORF">Hamer_G010602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MG75"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CID_RPRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032337">
        <property type="entry name" value="RPRD1A/B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16566">
        <property type="entry name" value="CREPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="283"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7153306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="357" mass="40676" checksum="8558CAC9A29D9D65" modified="2022-05-25" version="1">MANFNEDGLKKKLDDLNMSQQSIQTVSLWLIHHKKHAHTVVNVWYRELITATDSRKLTFMYLANDVIQNSKKKGPEYNKEFGSKLGKVFEHLGALRLDEKSLRGLNRLLNVWEDRSVFDADHIKLFKKNLRVYILPDSPILFGEEIAPRDVIKEKKEKRGRKEREGKKKEKKRRGRDKGKHDNPQSKKRRDSASDAIQPSTPESRLRRDSEGDLTQFAVSPQSSTPPSDPPEPEQLIEAIQELENAATSDALVREKIANLPDEVSDVNLLNKLQDLAAGRALCDQVEEALSMLEAYNKRLAEEMEARKAEHRQKQGKVKKVREELKAHLQNLPDISKLPSIRMGGLAPLPSAGDLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJA8</accession>
    <name>A0A8J5MJA8_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G010618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJA8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="115" mass="12756" checksum="35A3C089D12900AD" modified="2022-05-25" version="1">MNQVLETVRSIPAPGFQEVTREDLEEPMQKDNTNDVEDLLEDEEGGESGDAASDAGETEQRKVTTQKLSLLLGVFTSLQEMIQDIESESGEREQVIGVLESISRKYSTRSSTMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJH0</accession>
    <name>A0A8J5MJH0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Star-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">S-L12</name>
        <name evidence="2" type="ORF">Hamer_G019549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Multicrustacea</taxon>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046868">
        <property type="protein sequence ID" value="KAG7153487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009:SF2">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="Methyltransferase FkbM" evidence="1">
        <location>
            <begin position="25"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7153487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="221" mass="25630" checksum="927E3170AB17E4BD" modified="2022-05-25" version="1">MGTWADIRKHTRMFFTKQEGGFFIEVGALDGQQLSNTLWLEQELNWTGLLIEPDVYSYQALKSKHRRAWISNACLSEDNKVRETVHVTAKLRRGFVSQWQWHLLGASYQYGINRSPIFDEYLKQADQTYTKSTCFPLFSYILALNITSVDFLSLDTQGSEIDILKSLPWGQVNIRVIIVEIEDPKFAVGFTDYMTDKGYVLVDQETDYYFVRKGDPILTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK03</accession>
    <name>A0A8J5MK03_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045789">
        <property type="protein sequence ID" value="KAG7154042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MK03"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="290" mass="31220" checksum="F96495498C5E02BC" modified="2022-05-25" version="1" fragment="single">SQLFGDNVDVGLREDHGEASQVNVAESRSVNHELRLLESQIKLKEAEAKAKEVGIRQAEAEAKAKKAEAIAKEVGIRQAEADSKNLRLRIQLGHKVEFCCTRLQPNTGKPAMIVTAEANTSPVGGMAGMSKADSMPIALVSTKGEARESAVSVLASRDFDLFQESFVKDPDLGTFRPFLSQGTVEVDGVETPVTILRDSGCLQTLIKEGIANVACMHELPVAGVDLIFGNDLAGGQIGNVTPPPVLRERPESTAELQQLEDDMPGVFRLCAETRSMSMTNDHNVTPDVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MM05</accession>
    <name>A0A8J5MM05_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7156413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7156413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
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        <name type="scientific">Homarus americanus</name>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
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                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
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        </citation>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157040.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="73" mass="6965" checksum="6E65F86A2A440A2C" modified="2022-05-25" version="1">MFKAVIVVLSVFLLVAAAMASPMPDPGYGGYGGYGGGYGGYGGGYGGGYGYGGGYGGYGVGTGGYGGGYGYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MN89</accession>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
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                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="141" mass="15435" checksum="AE57E92AAD81AFE9" modified="2022-05-25" version="1">MWVPGVVVQTWAPGVVVQTWAPGVVVQTWAPNVVVQMWAPGVVVQMWVPGVVVQTWAPNVVAQMWAPGVVVQTWAPNVVVQMWVPGVVVQTWAPRVGAAQETGLGDTLRVVPFHVVPNKKPLKRLSEKNVPFIPMLNNHCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPE5</accession>
    <name>A0A8J5MPE5_HOMAM</name>
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    <gene>
        <name evidence="4" type="primary">Trim33-L</name>
        <name evidence="4" type="ORF">Hamer_G006221</name>
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    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Pleocyemata</taxon>
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            <taxon>Homarus</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPE5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
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    </dbReference>
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        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
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        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF304">
        <property type="entry name" value="BONUS, ISOFORM C"/>
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    </dbReference>
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        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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    </feature>
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    </feature>
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    </feature>
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7158854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="602" mass="66462" checksum="4DE6CDB0B8392B51" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPQ4</accession>
    <name>A0A8J5MPQ4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G006328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPQ4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="317" mass="34239" checksum="E4DB376BD571CDA4" modified="2022-05-25" version="1">MRGGGFVVVPDTTVETREMDNTATVLKAVVATIWLLGVAHLTPATTNNECKLNKLPETKDQGTLYAFEDKKLKAWIRTVGTAVLNLSVGNAGGQSETIGNSSDIRLDKWNQIVIEQITGDDGYTYSVSILDNTKWNSSKKQFPRNYVFPSSPGSKIRWSTCPPDDLMDFVGQQSSPTSEPSSSTTLAAQTPASSTPSSCTPPSAESCSDKEFGSNAMFLALGCGSMALVIAFLACVYAIVIRRKYLRLLSERGKIDREGKLGPGDENFYDEWDNNYKSQAGNLGNCQLRQSSSDAVADPTIRPGSSCSIAISIYGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR40</accession>
    <name>A0A8J5MR40_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromatin complexes subunit BAP18-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BAP18-L</name>
        <name evidence="2" type="ORF">Hamer_G001815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR40"/>
    <dbReference type="OrthoDB" id="10021571at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016589">
        <property type="term" value="C:NURF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000452">
        <property type="entry name" value="Chromatin complexes subunit BAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397:SF2">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="68"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="186" mass="19915" checksum="9AA8E88F43CA4595" modified="2022-05-25" version="1">MMQLYTPRTLNDAAVHTKNIECAAVHTQNMERLWKPLVGEIFLAAGTAFNKLAELTMQLHPTAEQSPAGTKWTDDEIEMLRSSVKRFGDDLNVISQRIKSRTVTQIRSALKKKAFEDVGISPQAAAALQAQQTTTTQAGASGGGGSMLGGRDVTLNMLNASESEVDVEGMGGVGMDFEGANEVVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRU6</accession>
    <name>A0A8J5MRU6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gamma-secretase subunit Aph-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aph-1-L</name>
        <name evidence="8" type="ORF">Hamer_G007371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APH-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRU6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009294">
        <property type="entry name" value="Aph-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12889">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT APH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06105">
        <property type="entry name" value="Aph-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7161735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="224" mass="24072" checksum="F88398DE6C38CBDA" modified="2022-05-25" version="1">MTVAQFFGCALIAFGPPISMFALTIAKDPIRTIMLVASSFFWLLALLFSSILYTLSPSYRTPSSLELSSLSYFRNCLVSGLGFGMISGAFSLVNVLADMTGPGTIGMKGDPYNFFIASAVTSLAFIMLHVFWGILFVNAIHRRAYLQLAYVILCHMLASCITLINPLYSVTIPTVWILTILSGVLAFIVAGGSHRTIKAAIGGHPRVLQVTTSDGNTTATVNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTV8</accession>
    <name>A0A8J5MTV8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative PMP-22/EMP/MP20/Claudin tight junction-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Hamer_G004540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTV8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005918">
        <property type="term" value="C:septate junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035151">
        <property type="term" value="P:regulation of tube size, open tracheal system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019991">
        <property type="term" value="P:septate junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284:SF12">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7163401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="230" mass="26630" checksum="008FC697CBC76089" modified="2022-05-25" version="1" fragment="single">SATMVNAGIIAFVATVFFVISFTSPYWLQSYSYTYSDFNNMGLWEFCFNGFRYPKYQYDYKFTGCNYIFSEEYRIIWSWMLPAWFMAVQTFMTIALLASMTTLVTISLILVRWPMHMIMKYEWYLTGFCFCCQAVAVIGIFFAVLVFGVMCWSRDWLLNPNFNYLSWSYAFAVVAGGIHAFAGFTLLHETFEARERKRQASNLLHMDPHGQMGMGMGMGMGMGMVSQGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU38</accession>
    <name>A0A8J5MU38_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G004492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU38"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="384" mass="43020" checksum="A76AB3738032BC34" modified="2022-05-25" version="1">MAALRMAGSWLQGSGWAETLVQIDIASPGTANSFLKAAHVTRTRRGHQITAATLNILQHKAYGKYTEDAQSDGHEPLEFGLADKITDASIILDESQLEYRSRLDLVWDCYLKSWSRKVTVRCNRGKGIRRRVTASGPLPSNWQNFLRNSDNKEELFSFLSEQVMQLVVKESKQLVVTDKKQVLTVPPRKDTANLAPFNHEEADTRMMVHAADALECGHRRILIRTVDTDVVILAVALANERSEILDELWLTFGTGKNRRYIEAHQIAKALGPEKSRALPVFHAITSCDTVSAFAGHSKKAAWATWNAFPEVTTAFLSLASTPSELPDGVLSTLERFIVLLYDRTSTCCDVNVLRKKLFSRKSRSLEHPPPTRAALEQHIRRAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUM2</accession>
    <name>A0A8J5MUM2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026055">
        <property type="protein sequence ID" value="KAG7163942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUM2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="134" mass="14785" checksum="664596F31C348FAC" modified="2022-05-25" version="1" fragment="single">FQVSLGQRSSNSKTSTCLARLLEFVESQSQSPSVEGPHNKNLSPSMDETKEIPNLPQPDLSGTRAARERVQAYKSRERARKASELDQLCAAAQDAHAGLRLYLLITTQEAPSPGPPTPAVVHLLTNRNEWLHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVX9</accession>
    <name>A0A8J5MVX9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G013159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024020">
        <property type="protein sequence ID" value="KAG7165651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVX9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="203" mass="23647" checksum="89951CC338B66338" modified="2022-05-25" version="1">MYERFWHEAPMAVRAPFNDLQLMKVLKEYPHEKVAHAAQAAISRHLWYLSEHLIGLSLFDDRIDTETKKNMVQNFQCPKKQDFSRRIVLSDETPISNVASFVTERALDIFDVLTLDGKERAQLFLSKDPKTWKDDEVFITMRDRAINMKVVNDSAERAIALKERYNESITQNEDQKQYLLQVVAAHRKKLPTASKAAMMKGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYP8</accession>
    <name>A0A8J5MYP8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017009">
        <property type="protein sequence ID" value="KAG7169385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYP8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="116" mass="12509" checksum="9E6C04DC35595FEB" modified="2022-05-25" version="1">MHSIVKSADKIKEMAGSATPLTAICTIIRNVKKDIPQAYYGVLEEKSKNAQQMNLDAFITAKPSTPNAPTTPPTSKQNTVFRQLFKTSVKPQPSTSEPQLSTSEPQPSTSGAFTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0A5</accession>
    <name>A0A8J5N0A5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily domain-containing protein 12-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Mfsd12-L3</name>
        <name evidence="4" type="ORF">Hamer_G012221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0A5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7170001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="336" mass="36482" checksum="A22E7F0CF7EE7A1D" modified="2022-05-25" version="1">MLRYSGLRLHPSAGLHDLSVPASRDQRRLMLPSGRHLTLPPPSPTHLTPTSRPSLPPNAHTRYILDVCSDVLVYLVAWITFAEDTTTANKFVDPGDASNFKTITITVLVVGTFFSVLFHLFTPERASTRTQAEAYQEVAASETQAETSPTTSTPQQEEQPVNSYTAHVRMMWKDWLAEPQFYQASVVVGIVIGLVAATVSALPWIPEFGMYIVAILWGTSSSILVIISLAFTADLIGRSTESSAFVYGSMSFADKIINGVAVLIIQELTSLGIFVPLMTAFIAICLINRQRLGRTQKLLQAERETGEASGSSLSSNSSELLLSTGTNLGYGAITKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N109</accession>
    <name>A0A8J5N109_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Polysaccharide deacetylase-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G013817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012455">
        <property type="protein sequence ID" value="KAG7171350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N109"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF8">
        <property type="entry name" value="CHITIN DEACETYLASE-LIKE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035267313" evidence="1">
        <location>
            <begin position="24"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="60"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7171350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="393" mass="44571" checksum="E0A27A468BF68EFA" modified="2022-05-25" version="1">MSSSSWWCFLVVALLVSALVVTGTTTEDEVCEQDKNCFLPNCLCGSVTHPGNIPFDEVPQFVVLSFDSAVRDTNIDFYLKFKDFMNPNDCRITMTFFLSHLYANYPMVNELHRIGHEIGLHSVTSSDVENYWRPANESVWMHEMDDLRTIIENNAFIDKKHLKGWRAPYLELGGDEMFSALNELGLEYDCSWPTLRYTNWFGSNPIGALYTPSTTPASRTVSSDDALPRGTTGWVVPMIDLNDNTGEACAMLDNCNGNFNLNYLNNKAPFGIFSHYSWFLEGHLNGTDARETGYTRFLEWLSSKDDVYVVSVDRLLEWMKNPVPLSEVGTLDAFKCSADPRPDCVDPQEYTFSMEDNLPNSLDEVIMGSCTRPQPDYYPWLYNPEGDLNIPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1P5</accession>
    <name>A0A8J5N1P5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">mRNA export factor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rae1-L</name>
        <name evidence="13" type="ORF">Hamer_G014712</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1P5"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000084">
        <property type="entry name" value="mRNA export factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="83"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="124"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7171577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="368" mass="41113" checksum="5AF3D0D3CA7E4006" modified="2022-05-25" version="1">MFTPSTFGSSGSGFSGFGLSTSTPASANPMKDFEVVNPPDDSVQCMAFSPPSIPQDFLVAGSWDNNVRCWEVQRDGKTIGKAQQTMGGPVMDVAWHDDGSKVFMASADKTVHCWDLGSNQKMQVAQHDAPVKTVHWIKAPSYSCIMTGSWDKTLKFWDTRNPQPIMTINLPERCYCADVEYPMAVVGTANRHLIVYQLETQPQEFKQIESPLKYQHRCVAIFKDKKGAGAPAGFALGSVEGRVAIQYIVTASPRDNFTFKCHRSNGTSNGFQDIYAVNDIKFHPVHGTLATVGSDGRFSFWDKDARTKLKNSEAMEQPISCCAFNHNGQIFAYAVSYDWSKGHEYFNPQKKNYIFLRSCYDELKPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N259</accession>
    <name>A0A8J5N259_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Integrin beta-4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ITGB4-L</name>
        <name evidence="14" type="ORF">Hamer_G000695</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the integrin beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N259"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000036">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012896">
        <property type="entry name" value="Integrin_bsu_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036349">
        <property type="entry name" value="Integrin_bsu_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF42">
        <property type="entry name" value="INTEGRIN BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01242">
        <property type="entry name" value="Integrin_B_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69687">
        <property type="entry name" value="Integrin beta tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52047">
        <property type="entry name" value="I_EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0401">Integrin</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Integrin beta subunit tail" evidence="13">
        <location>
            <begin position="248"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7171784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="323" mass="35934" checksum="9786DEE8244B3A1B" modified="2022-05-25" version="1">MQHGTGRTGRGRIRDRVEDVDDGRSLTREERRRQREARRQERIQRREDRRRQKQSVQRVGQEPGDEEPDQVVDLVWLRANLSSLWREFRAFTRQQGRGHNHRGSVQRGHSDTMGVTEDHSLCPTGVESCQAADGQICSGHGECSCGHCQCEPEHYGSKCQCNDHTCQLYDGMSCGGPSRGQCRCGGCMCRSGYIGEACNCPTQTQICINPGDKNICSNKGTCECGRCHCEDGYKGMYCEDTVYAAGVCEKLKPCVLCKAGMRGSPTCDQCQITVTAVNNLEPSMTTCVMVNSGCILKYSYIAQTSNAYTVLLERNNECPSQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N295</accession>
    <name>A0A8J5N295_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor E2F8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">E3f8-L</name>
        <name evidence="8" type="ORF">Hamer_G000738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N295"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR EFL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="247"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="355"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="691"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="808"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="691"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="810"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7171818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="861" mass="93179" checksum="302B95F26B43E966" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2C2</accession>
    <name>A0A8J5N2C2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G000782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2C2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7171859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="780" mass="84912" checksum="56CE339A038D3455" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3J8</accession>
    <name>A0A8J5N3J8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Decapentaplegic-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dpp-L</name>
        <name evidence="11" type="ORF">Hamer_G006927</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3J8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13756">
        <property type="entry name" value="TGF_beta_BMPs_GDFs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000001">
        <property type="entry name" value="Bone morphogenetic protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="10">
        <location>
            <begin position="389"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="354"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7172702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="511" mass="58375" checksum="9D5CA5DF8663FE44" modified="2022-05-25" version="1">MYVFHLLFSGMSPAPSPLTAAVSPNAATASPHTATVSPHTAALSPRAAAGRPVPRYMWEMYHLMLSTHDASCSAFYVLFDLRGGDEAEGDLLSAHLYVELSPRHSDAARHTYGKNNHLKNPHNKDEHLKNSHAKRDHFKNSGSNSDLRKDPHSKNNHFSDPRNRRGYPKNRSSNKEHVKINHNNMNRSEIYHSKEKHPQKYPGKNYHLKNPDNKEGRDERPRPTIHAHRKNCRMKYLRHARATEGWTGETTLTLLQVTITHLANSTAPATEVVRVGQDAVFDVTTEVRTWEVGGDYRVTVDVRPLDTGNHPLELHGGEDCDKLMWEVSLMVVREDLDASPSSRISFYPLEAMGKETEEYEEEEEELEKEATMEEEDEEREEEKEESRGRLRRSRLLRRQERGGKKWEGNNRCQRRSLYISFKDIGWDHIISPIGYEAGMCRGECKLPVPEGDSYTNHAFMSVLLHDRWGRGQGACCVPTKLDSLTVMMYNQAGDPVLKNFNKMAARKCECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7M9</accession>
    <name>A0A8J5N7M9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Translation initiation factor IF-2-like 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">infB-L29</name>
        <name evidence="1" type="ORF">Hamer_G032146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007148">
        <property type="protein sequence ID" value="KAG7174727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7M9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35001">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35001:SF5">
        <property type="entry name" value="PROTEIN CBG01852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="336" mass="35539" checksum="DDCBD789A506C7E2" modified="2022-05-25" version="1" fragment="single">MTFGPWDQGILGLVRRPIGPELLGRSSTGHFFGSVPFGDHLQGSVLFGDHLQGSVLFGDHLQGSVLFGDHFQGSVLFGDHLQGSVLFGDHLQGSVLFVTTSQSVLFRGVSSSVTTCKGVSLFGDHLQGSVLFGDHLQGSVLFGDHLQGSVLFGDHIQGSVLFGDHLQGSVLFGDHLQGSVLFGDHLQGSVLVGDHLRGSVLFGDHLQGRVLFGDHLQGSVLFGDHLQGSVLFGDHLQGSVLFGDHLQGSVLFGDHLQGSVLFGDQLQGSVLFGDHFQGSVLFGDHLQGSVLFGDQLQGSVIVGNHLQGSVLFGDHLQGSVLFGDHLQGSVLFGDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N862</accession>
    <name>A0A8J5N862_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tigger transposable element-derived protein 1-like 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIGD1-L14</name>
        <name evidence="5" type="ORF">Hamer_G021916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006858">
        <property type="protein sequence ID" value="KAG7174814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N862"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF26">
        <property type="entry name" value="TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="420"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="510"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7174814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="555" mass="62950" checksum="8D12D47A0FC9EF32" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAQ8</accession>
    <name>A0A8J5NAQ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dedicator of cytokinesis protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Dock7-L</name>
        <name evidence="7" type="ORF">Hamer_G016998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7176034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08696">
        <property type="entry name" value="C2_Dock-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000002">
        <property type="entry name" value="Dedicator of cytokinesis protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.410:FF:000002">
        <property type="entry name" value="Dedicator of cytokinesis protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037808">
        <property type="entry name" value="C2_Dock-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF76">
        <property type="entry name" value="LD20667P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="5">
        <location>
            <begin position="539"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="6">
        <location>
            <begin position="1674"/>
            <end position="2103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1445"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="408"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1445"/>
            <end position="1462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7176034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2108" mass="238395" checksum="DC1F10C0038AE74C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAW7</accession>
    <name>A0A8J5NAW7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G024243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003893">
        <property type="protein sequence ID" value="KAG7176186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAW7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7176186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="83" mass="9520" checksum="6364F97718227AA7" modified="2022-05-25" version="1">MWAWQGRLSGGGAARATRQSAGRLPRITMFSSRKALVMVVLVMVMMAGMVEPSPVYGYYRRSSYRPRWKSYRGFTVCKQFFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NB45</accession>
    <name>A0A8J5NB45_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G009148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NB45"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7176352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="442" mass="45191" checksum="5EEFFA4B72AB4CD5" modified="2022-05-25" version="1" fragment="single">SLLLLESLTQAQIHGGTTVDGEALAADVTTPGPGSDSSPGPGLDTTPGSGLDTTPGSGLDTTPGSGLDTASGPGSDPAPGPVSEHSIAVTSMPNSEGNETMTTSEISTVTTTERSRDTSDTSLASEAATVTPAIDTDDRQLDATTTQETVLLNVGSEIDTNDISSPSPHSSTIEPAVGDEEVEREPSFAVVSTPSSSLNTINQEANTLPLDEEHSTEASLPDSSPEPVPDEDMTSLNAKVPPLIATTSTLPQTTPEEGGHPELHISSSTAAPMNSTVTPSDASTTETEIHTISTLPHSTSTEPSPSSSGPVSTTVTADSSGGCFGEAEVNTVLVVAVVVAVNVLSVVVTAVCVHRIVSRRLSWDPPPVHYNRSKRAEQARQGGPRSGLDLASDTDCKAGEGEGAPATNIPIIITNEDGWCVPYSEQDQKKKKGSPATEDTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NEE6</accession>
    <name>A0A8J5NEE6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027219</name>
        <name evidence="3" type="ORF">Hamer_G029002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012175">
        <property type="protein sequence ID" value="KAG7171419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010001870">
        <property type="protein sequence ID" value="KAG7177774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NEE6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF16">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="266" mass="29382" checksum="F86E6A614C476FC8" modified="2022-05-25" version="1">MRVTRNVTEIRRKFSADLRVSVKKKAAQDKKYAGGTGGGPQIEITYTAIEEAILQLLDPTSIHGIPGDVESEEPSNEEEREPTPRPSGARFTATGSCFREKFMFRPVQEKDDSITRILNEDIQEHDITVPIVHLEPETSAPTNIPGFSSSGTYEVETCSSSNARQPIAATKEQRSRSSTPSATAVRSTVTGDYTDEMDSSPMPSTNSSGRRPRTSSARKDEDLLREMLRVQTQMRDSFLQLVAHTECIASAMLCIAKVMQSKNPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NEX2</accession>
    <name>A0A8J5NEX2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Interferon alpha-inducible protein 27-like protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">IFI27L1-L</name>
        <name evidence="13" type="ORF">Hamer_G008352</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NEX2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051435">
        <property type="entry name" value="RING_finger_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791:SF6">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="96"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7177688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="263" mass="26621" checksum="07C56EE1B858C767" modified="2022-05-25" version="1">MATDRINATAKNIPVMMAGDGDSWKRCGVCDNDYDSLHHVPVFLPACGHTFCCPCLIKINNINEKLNCPICREPHCGTSPENLPKNRAVLDMLPPKSQRDEQHHTDKGAPKDPSPPSNPQSSKSKLHHTDKGAPKDPSPPSNPQSSKSKPPPKASKGWIYGLGIAAGIGFTSAGIAASSIASAMMSSAAIANGGGVAAGGLVAVLQSAGAAGIGLGANACIAGAGAAVGAGVGAVAAKVGDRNNHDNDDTSQSASVCKFDGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NG71</accession>
    <name>A0A8J5NG71_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pollen-specific leucine-rich repeat extensin-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001802">
        <property type="protein sequence ID" value="KAG7177791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NG71"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035255477" evidence="1">
        <location>
            <begin position="22"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="189" mass="20800" checksum="E8A96FE185CD6502" modified="2022-05-25" version="1">MSPSRCLFAKLSFHLSFLVNGNPFTPFSLYLAIPPPHYSSTPLSLHSTIPPPRYPSTPLSLHSTIPPSRYPSTLLSLHPAIPPLHYPSTLLSLHSTIPPLPLSLHSRYPSTPLSLHSAIPLHSTIPPLHYPPHSTIPPPLLSLRPRYPPPPHSLHPSYPSTLLSLHSTIPHSTIPPPRYPPTPLIPSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T2Q9</accession>
    <name>A0A8J5T2Q9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase chain 4</fullName>
            <ecNumber evidence="4">7.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">NADH dehydrogenase subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">NADH dehydrogenase subunit 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase chain 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">ND5-L4</name>
        <name evidence="25" type="ORF">Hamer_G009526</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T2Q9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000260">
        <property type="entry name" value="NADH4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010934">
        <property type="entry name" value="NADH_DH_su5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829:SF2">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06455">
        <property type="entry name" value="NADH5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01059">
        <property type="entry name" value="Oxidored_q5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="17 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase chain 4 N-terminal" evidence="23">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="22">
        <location>
            <begin position="159"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="22">
        <location>
            <begin position="305"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="NADH dehydrogenase subunit 5 C-terminal" evidence="24">
        <location>
            <begin position="514"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="25">
        <location>
            <position position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF01059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF06455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAG7172185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="648" mass="71655" checksum="DAD76D2357C8DD4D" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T4W0</accession>
    <name>A0A8J5T4W0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PHD finger protein 19-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Phf19-L</name>
        <name evidence="7" type="ORF">Hamer_G008527</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T4W0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025894">
        <property type="entry name" value="Mtf2_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14061">
        <property type="entry name" value="Mtf2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Polycomb-like MTF2 factor 2 C-terminal" evidence="6">
        <location>
            <begin position="265"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7173009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="313" mass="34653" checksum="6BC7E3F494B477CF" modified="2022-05-25" version="1">MARFSPAKKRAVSPVALEPDEESPSSSGKRKRKRELDILMEDKKAKKMIEEIGSVKENSITDSQAPIKRKRGRPPKNQQSIKSDDLRDLKQKRAQKLLKEALKQGQGMRPVTKSGLEIPTPNCITPGDTSGDETSSHGTLDSFIPPPSNFEGQNNPFLNLDSLSYGLPVVRPLKRKLNESDIRIGKNGEVKRRRFRKKCDKAKIMFLLQNGSLSINGGNGIRLNGTNSIKNCVDYALSGRLNAGSKDDCSDIVEDPKVGDSGFSFSDLKSTVNNYFGAANRIASGEKFHVIARRVSFEDKVQYLIEWDSPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T9A1</accession>
    <name>A0A8J5T9A1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Myosin heavy chain, muscle-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Mhc-L1</name>
        <name evidence="17" type="ORF">Hamer_G003129</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060972">
        <property type="term" value="P:left/right pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031033">
        <property type="term" value="P:myosin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000036">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000008">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000019">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000021">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000025">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000009">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000010">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="7 12" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="16">
        <location>
            <begin position="35"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="15">
        <location>
            <begin position="87"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="621"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="12">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1730"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="894"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1738"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="180"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7174224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1962" mass="224656" checksum="B9F05F3A0DCAB726" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIM7</accession>
    <name>A0A8J5TIM7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glutamate receptor ionotropic, delta-1-like 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Grid1-L28</name>
        <name evidence="15" type="ORF">Hamer_G016972</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7176009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIM7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="203"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7176009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="560" mass="62634" checksum="CE3913D83F9B681B" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJ19</accession>
    <name>A0A8J5TJ19_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hagh-L</name>
        <name evidence="11" type="ORF">Hamer_G009870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJ19"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7175846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="207" mass="22640" checksum="38DC060767D19F9F" modified="2022-05-25" version="1">MIQDHAGGNKELVELFGKPLKVVGGDDRIGALTQKVSHGDTFTIGSLKVECLFTPCHTQGHICYSVTSDDPHHKPAVFTGDTLFLGGCGKFFEGNAVEMHRALIEVLGALPDHTHVYCGHEYAIQNLKFGAHVEPNNTAIQEKIAWVQQQRDEGLPSVPSTIGEEKQINPFMRVTEASVQQHANTTDAVTTMAAIRAEKDNWKAPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJN6</accession>
    <name>A0A8J5TJN6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">RPS6KA3-L</name>
        <name evidence="18" type="ORF">Hamer_G014522</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010010116">
        <property type="protein sequence ID" value="KAG7173207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJN6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05582">
        <property type="entry name" value="STKc_RSK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000010">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000013">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016239">
        <property type="entry name" value="Ribosomal_S6_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041906">
        <property type="entry name" value="RSK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000606">
        <property type="entry name" value="Ribsml_S6_kin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="30"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="17">
        <location>
            <begin position="289"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="390"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="36"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7173207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="573" mass="64761" checksum="E7CF74BC32F47842" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKV5</accession>
    <name>A0A8J5TKV5_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Putative Liprin-alpha-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003425">
        <property type="protein sequence ID" value="KAG7176460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKV5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="25"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="703"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="736"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="834"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="916" mass="104415" checksum="1B0C30201FAAE6E4" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TL83</accession>
    <name>A0A8J5TL83_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Nsa2-L1</name>
        <name evidence="10" type="synonym">Nsa2-L2</name>
        <name evidence="11" type="ORF">Hamer_G003380</name>
        <name evidence="10" type="ORF">Hamer_G029164</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030020">
        <property type="protein sequence ID" value="KAG7161095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TL83"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
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            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7161095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7174437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="260" mass="29758" checksum="CFDD64FC8EBBB2F4" modified="2022-05-25" version="1">MPQNEHIELHRKRHGRRLDFEERKRKKEAREPHERSAKAKKIFGLKAKLYHKQRCSEKIQMKKTIKAHEAKLTKQKDTDAVPEGAVPSYLLDREGQSRAKVLSNMIKQKRKEKAGKWDVPIPKVRAQSEAEVFRVVKSGKRKSKAWKRMVTKVTFVGDQFTRKPPKFERFIRPMALRFKKAHVTHPELKATFCLPIIGVKKNPSSSTYTSLGVITKGTVIEVNISELGLVTQSGKVVWGKYAQVTNNPENDGCINAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JB83</accession>
    <name>A0A8J5JB83_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger protein 768-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Znf768-L3</name>
        <name evidence="2" type="ORF">Hamer_G029931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045175">
        <property type="protein sequence ID" value="KAG7154124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JB83"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="229" mass="25911" checksum="84B02C23EEF1008C" modified="2022-05-25" version="1" fragment="single">MEQDVIATERKVQQDLDDLTKADPTLVIVMGVMGGLVLRVEVWAASSSTLVEERPISMSPPHGGRHNLGFQSDDPQRTCPRPRLEGDQHDPRAVNHDPRAVNYDPKAANYDPRVVNHDPRAANYDPKAANYDPRAANYPKAANYDPKAANYDPKAANYDPKAANYDPKAANYTNRDKHDRRTRQPQRPPRENGYHSESSRYYSDSAQREGGRTNDDLNDPYSLERRSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JBA9</accession>
    <name>A0A8J5JBA9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043243">
        <property type="protein sequence ID" value="KAG7154965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JBA9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="194" mass="21064" checksum="093F8AEF85C4E37E" modified="2022-05-25" version="1" fragment="single">MSDVQEWQYGASEMADSNRNGKQYQGWQTVTGMADSNRDGKVTTSGMANNTFSDGRHIGTCHCPSLSTIICTCHCQPSLAPVSHPGLASGTLSHHWHPALRILTTIYTHRHPSLGTHHWDPLIIGVALPFLVRLLTRETKSCIHLPGDVVLVVLVIVDVVSLNRRLCTSADEVSDNFTTGCIADSEPPTPTVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCL8</accession>
    <name>A0A8J5JCL8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G010622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCL8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="73" mass="8234" checksum="05D6EAB5E901601E" modified="2022-05-25" version="1">MTSVHTQPRLASPQTRPRMTPVHTQPRIHLGMGFEDELRPDALNFVVHAELDEPRARIHQPARPKLGGHVSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDB6</accession>
    <name>A0A8J5JDB6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative BAI1-associated protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G019981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044137">
        <property type="protein sequence ID" value="KAG7154563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDB6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052095">
        <property type="entry name" value="UNC-13_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999:SF4">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="486" mass="54226" checksum="3A695D6C0F25E041" modified="2022-05-25" version="1" fragment="single">MFKIYGFSLKKPWKPTAPSSVATGNQTEVRSSTSVRNSGLVEGSAEGRDVADVAGISDDVQEEKEEEEGVRRNRLERRSEEHGRLVAAQVFLSWPQEGSRRAYQSSLTTALDHHHLSTTTQGGGDDRSRLWNGHLSSKATEDLHHLGTKLRLSQEVQQLAWWVVGSRLASVDALWTYNQLQVVQKALADGAYGQEDLDELLHSLTLYIYSQIKRLKSLHSAFPGTQAGRQLTYTLRSLQGLEQHPATRQLLDQAGQPVLPEDILAAILRHAHDWWAGVLQVIQKEEATEENPHQQVPALVEVTHMALTFLQQDAQHYDHIFNKEMGVTYTSISYGEFSKQVAQVLRPLLRPSPPRYPTRGELDGEQHRSKFVHNFDVGSSLWSLYHNLRHMHAVGVQAGGGRGEDEGRGGGRRGRETGGEGAPVESFPSWFMDSVATWLTHSQQENQRLLQEALLQDSLSVVTITPADSNTQTTSMLSNDALLQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDQ2</accession>
    <name>A0A8J5JDQ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative i-type lysozyme-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046276">
        <property type="protein sequence ID" value="KAG7153865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDQ2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="854" mass="95133" checksum="122A510752E3D0E6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JE87</accession>
    <name>A0A8J5JE87_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sorbin and SH3 domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Sorbs1-L</name>
        <name evidence="6" type="ORF">Hamer_G024636</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042215">
        <property type="protein sequence ID" value="KAG7155279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JE87"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sorbin and SH3 domain-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="273"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="345"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="465"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7155279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="524" mass="59539" checksum="0E04D1E962F85BD1" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEJ0</accession>
    <name>A0A8J5JEJ0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysostaphin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lss-L</name>
        <name evidence="2" type="ORF">Hamer_G019819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047210">
        <property type="protein sequence ID" value="KAG7153253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1384"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1547"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1584"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1720"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1911"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2108"/>
            <end position="2139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2186"/>
            <end position="2209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1394"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1720"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1816"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1921"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1959"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2195"/>
            <end position="2209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2209" mass="253133" checksum="6B78413C693E6FF5" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEN8</accession>
    <name>A0A8J5JEN8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thyroid adenoma-associated protein-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Thada-L1</name>
        <name evidence="2" type="ORF">Hamer_G023863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042696">
        <property type="protein sequence ID" value="KAG7155186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEN8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="1">
        <location>
            <begin position="444"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="923" mass="104245" checksum="DA44FD95EC695BD7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JF15</accession>
    <name>A0A8J5JF15_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">sphingolipid 4-desaturase</fullName>
            <ecNumber evidence="3">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DEGS1-L</name>
        <name evidence="12" type="ORF">Hamer_G018154</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010044460">
        <property type="protein sequence ID" value="KAG7154420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JF15"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7154420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="323" mass="37501" checksum="3DB5D5EF6C41C013" modified="2022-05-25" version="1">MGQHVSRTDFEWTYTAEPHATRRKEILKKHPEIKELFGNDPHLKWWVLVLVTFQFLSLFVVRGLSWPWVLILSYCIGGTINHSLMLAIHEISHNLAFGHSRPLSNRILGIFANFPIVLPFSVSFKGYHLEHHKFQGDEKLDTDIPTDLEAKLFCTTLGKMVWMFFQPLFYALRPLITYPKTPTMLEVINTTLQLGFNFLVFYYLGGKAFTYLAAGSLLAMGLHPVAGHFISEHYMFKRGFETYSYYGPLNYLTFNVGYHNEHHDFPYVPGCRLPKVKELAPEFYDELPQHNSWVKVIYDFITDPSIGPYARIKRKHAGYSKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIF6</accession>
    <name>A0A8J5JIF6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate sulfotransferase 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Chst6-L</name>
        <name evidence="4" type="ORF">Hamer_G021459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036980">
        <property type="protein sequence ID" value="KAG7157771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIF6"/>
    <dbReference type="OrthoDB" id="6370549at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="156"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7157771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="448" mass="50953" checksum="84A3D5B943DA40B9" modified="2022-05-25" version="1">MIEAHTWEPRRKHSDILTTHDMIAGTRRKFFNKKLTVIIIWVLAVLLLICIYTPANTWRVGGKDNSTRANTRKEDEEKGEDDVRDDGEKDDEPQQQAVDVNHKDPTQHAGVHQKSQHNSSPAFKEVNPSQNQAQGGVKIERNKKSAEDVGTRFNVLLLSSMGRSGSSFVGGLLRSQPGVFYFFEPLHRLGNSGLITPQTAIQELQGIFTCNISDVLLKGFRKEPKFTIRHNYIHTCGKDCFKPKQLNQACRSEPIRVVKTIRTRLSWLLPLLNDSSSRVKVIHLVRDPRGALISAWKIKWTISSSVSCCDIRKDLYSGKDILQVFPNRYLAVRYEDLCSDPWGMARLIFNFLGYQTLPPSTVAFVKSYTSHGNPERTFGIKRNTHSMQQKWRGDITEAELKKIETTCNSTIIDIGFNLFHNLDAARNLSLPLYIDSKTNQFFPNSTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ34</accession>
    <name>A0A8J5JJ34_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G009969</name>
        <name evidence="3" type="ORF">Hamer_G028989</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010001181">
        <property type="protein sequence ID" value="KAG7177913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJ34"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="111" mass="12880" checksum="45B329901F69D5DF" modified="2022-05-25" version="1" fragment="single">MKRNHDVKASLVCYENSDKVLLYNPLLKKGQSPKLQSPWEGPYTVVERLRRKRKAQPKVVHVNRLWQYHGPGQYTWEDCEEQPSTTDEDQTGGPGRTQDDPGNPTMEQEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ41</accession>
    <name>A0A8J5JJ41_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative COP1-interactive protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJ41"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="303" mass="34275" checksum="030F8DA88CD87AEB" modified="2022-05-25" version="1">MERREDSSELHQSHPVKEAGSISLCEGGGQREEDDESKHLESMSVSSSHSGRPQFSLPSKGSRRSHKNLLGDMDQRDYEGDGEISHTSVRSSSRTSNSRGESSRAWQHKRRKSEISQGDTCSTDDQDDDLCHSRSVSDGGETVNETSLEETSFNTSVYSDKGVDSSSELSIDPEIWTKFKFLSSILKETQHNLRAMDNLILEHRRLQNQAEQNKEHTIVSHVTIPIHQGLGDGEPKTDEAKLEEILSLLHNLTHTLTSYEQHPLLLKKTKESEYLFLDRENKRQSMKEESVLYFLLESGHPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ84</accession>
    <name>A0A8J5JJ84_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Neuronal acetylcholine receptor subunit alpha-7-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Chrna7-L3</name>
        <name evidence="7" type="ORF">Hamer_G023282</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045124">
        <property type="protein sequence ID" value="KAG7154134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJ84"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000060">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit alpha4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="198"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7154134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="440" mass="49502" checksum="0DE0C8FFC7EE0437" modified="2022-05-25" version="1">MTQGGSLADIHSMAFTCIHTFTLPPHYLHAFHITSTPSTLPPRLPHYLHAFHITSTPSTLPPRPLHYLHAFHITSTPSTLPPRLPHYLHALSITSTPSTLPPRLPHYLHAFHITSTPSQLPPRLPHYLHALSITSAPSTLPPRLPHYLHLVSIIWLDDHRVLSASLMQLWCYTAGRSQGVVDLPDAAVVLYSWTITGADEGFDGTYQTKVVVSSNGNCLYIPPGIFKSTCKIDITWFPFDDQRCKMKFGSWTYSGWQLDLQLQSEDGGDLSDFIKNGEWDLIGCPGKRNAIYYKCCPEPYVDVTFEIVIRRRTLYYFCNLILPCVLIASMAVLGFTLPPDCGEKLSLEVPGERNELTYQCCPEPYVDITFYIKIRRRTIYYLYNLVLPCIMISSMTLLGFSLPPDTGEKLTLGMAFTTASSLYCSASTLAFTHPPQRSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJH1</accession>
    <name>A0A8J5JJH1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vigilin-like 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vgl-L40</name>
        <name evidence="5" type="ORF">Hamer_G029706</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035246">
        <property type="protein sequence ID" value="KAG7158401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJH1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="40"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="119"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7158401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="215" mass="24037" checksum="E9B3E4D7565949A9" modified="2022-05-25" version="1">MSSRVNNNPFERRQVMKVNQEKSRPLPPWMSRMRAQWVEETVSETVKADNCLFGVIIGPGGSTMKELQVKYNIRVLVPRKGSKDEPIIVEGKDKTLVKDAVLRIKALIAEEKERRRVTTPVSQTLCIPKALHGKVIGLKGQNIRPVTQALKIKIKFPNKNDNSDEVTLTGLPDQVETFIDVFYNDCDNNLDEEENGMSSCVCGVEGLNVKVGLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJP5</accession>
    <name>A0A8J5JJP5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">Rho-L3</name>
        <name evidence="24" type="ORF">Hamer_G005693</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Photoreceptor required for image-forming vision at low light intensity. Can use both retinal and 3-dehydroretinal as visual pigment. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Signaling via GNAQ probably mediates the activation of phospholipase C.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with GNAQ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell projection</location>
            <location evidence="19">Rhabdomere membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJP5"/>
    <dbReference type="OrthoDB" id="6332316at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15079">
        <property type="entry name" value="7tmA_photoreceptors_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000044">
        <property type="entry name" value="Opsin, ultraviolet-sensitive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0157">Chromophore</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="7" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="16" id="KW-0807">Transducer</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="18" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="23">
        <location>
            <begin position="69"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAG7157293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="375" mass="42016" checksum="AF03B11C5F056753" modified="2022-05-25" version="1">MSYWDNPANYASGGPSTNPYGNYTVVDSASQEILHMVDPHWYQYPPMNPLWYGLLAIFMVVMGTLSVCGNFVVIWVFMNTKALRSPANLLVVNLAISDFLMMFFMCPPMVINCYYQTWIWGAFACELYGCIGSIVGCCSIFSMVFITLDRYNVIVKGVSATPLTTKGAMLRILFSWLTAIGWCLPPLFGFNAYVPEGNLTACGTDYLKESLSSHLYLYFYSSWVYFTPLTIIVYSYTFIVSAVSAHERQMREQAKKMGVKSLRSEEAKKTSNECRLAKVALMTVSLWFMAWTPYLIINYAGMINKPSVSPLLTIWGSVFAKANSVYNPIVYAISHPKYRAALEKKLPCLSCATEGRESQGDTTSTVTTNEKSESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JK81</accession>
    <name>A0A8J5JK81_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Neuronal acetylcholine receptor subunit alpha-6-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Chrna6-L4</name>
        <name evidence="20" type="ORF">Hamer_G006273</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Synaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JK81"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035267273" evidence="17">
        <location>
            <begin position="20"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="28"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="242"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG7158896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="413" mass="46261" checksum="C6700987C0936E90" modified="2022-05-25" version="1">MVWQLVVMAALTAATSVFAGDTVWKKEDKLREDLLKNYSKHSLPHRTVNGTTTAYFGFQVMAVWFEEGKEILNVNAWSRMVWHDPHLVWDTKQYDGINVLHVHYQTIWKPEIYLYNNADLSSVNHFSGTKALVYSTGEVLWVPPSLFKALCPLDYTYWPYETQTCDLFFGAWTYNGWQVDLQLYHNQSSVLAGNNKLSRSWMMVSGKIQKHVIQYKDMPPYSLLQVSLVLTRTSPSFTSTVVLPACVISVLTLVQFVLPLREPRRLTLGCMSLLLTLLLLLYLATIIPPTATSLPIIVKFYGQTLVVVVVSVCVSASLLRLTDSRHPASTAPPPTLLKTILTGPLGTILFLQRYTDKVGLSGGGGEDGEVLEEARPASYLHEWILVAAAVDRLAALTFVATFVITLIAYVSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JL59</accession>
    <name>A0A8J5JL59_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037472">
        <property type="protein sequence ID" value="KAG7157510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JL59"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="395" mass="44449" checksum="8E1DE1A6350EA081" modified="2022-05-25" version="1" fragment="single">TKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKKPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERREGRSCEYYLHVLATTYLPPPRFGHHSPPSSTSWPPHTSLLHVLATTYLPPPRFGHHSPPSSTSWPPLTSLLHVLATTHLPPPLLGHHTPPSFTSWPPHTSLLHFLATTHLPPSRLGHHTPPSFTSWPPHTSLLHVLATTHPPLTYELCRYLKLTPGVLAVCKRDICAAQCTHSRCKSVMFIHINSGGKQFTNNCIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNI4</accession>
    <name>A0A8J5JNI4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyoxalase domain-containing protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Glod4-L</name>
        <name evidence="4" type="ORF">Hamer_G004074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyoxalase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNI4"/>
    <dbReference type="OrthoDB" id="1545884at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16357">
        <property type="entry name" value="GLOD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08358">
        <property type="entry name" value="GLOD4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043193">
        <property type="entry name" value="GLOD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043194">
        <property type="entry name" value="GLOD4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46466">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46466:SF1">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21701">
        <property type="entry name" value="GLOD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="137"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7159446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="295" mass="32852" checksum="F39E6F92EC7D43D5" modified="2022-05-25" version="1">MASRRALHFVYKIGDREATAKFYREILGMKVLRHEEFEKGCEATCNGPYDGKWSKTMIGYGPEDNHFVCELTYNYGISHYEMGNDFLGMYIESSEALERAKASDWPVKQDGEHSVLEAPGGYKFFIINKPQPGDRDPVQQVVLASSNLEKSIKYWRDLAGLTMYKKTDKAATFGYANTQAKVILQDIGGPVDHAKAFGRVAFAAPGDELLGIEKTMKKANQTIVKPFISLETPGKAMVEVVILADPDDHEICFVGVEGFTELSQVDPKADDLLNEAMEKDKSDEWFAKKGGKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNW6</accession>
    <name>A0A8J5JNW6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tigger transposable element-derived protein 4-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TIGD4-L3</name>
        <name evidence="6" type="ORF">Hamer_G006487</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNW6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7156519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="219" mass="25301" checksum="78243C2CD55983D6" modified="2022-05-25" version="1">MPKCTCTIPSSSEKKKRKTFNIGDKVKILNEFEQGASASVVARRYGVNESTIRGIRQKADKIHAAFAEPTVSKTTQHLRPPLYQEMEDTLKIWIENMQRRKVAISGPMIKNEAMEIQTRLLQRDGKPLAEMTKEHEEEEEAEDVPPHVKKEWKITQLKEYMTFIYAAIKCIRDNDPDLGRATENVDSLYRLSSTYSRLLDRKIANQKQRSTTSYFRCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPF1</accession>
    <name>A0A8J5JPF1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin-related protein 2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Actr2-L2</name>
        <name evidence="8" type="ORF">Hamer_G028034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028952">
        <property type="protein sequence ID" value="KAG7161535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPF1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7161535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="293" mass="33119" checksum="A4693083757C4E2A" modified="2022-05-25" version="1">MSHLINFVNQLQFVKVGYAGCNFPAHIFPSMVGRPIIRATNKIGDIEVKDLMVGDEASKLRSMLEVTYPMENGIVKNWDDMCHMMFEKYGFAGAFVAIQAVLTLYAQGLQSGVVVDSGDGVTHICPVYEGFTLPQIRRLDIAGRDITVYMIKLLLLRGYAFNHSADFETVRMMKEKLCYVGYNIEQEQKLSTETTVLVENYQLPDGRIIKVGGERFEAPEALFQPHLINVEGQGIAELLFDTIQRCDIDIRPELYKHIVLSGGSTMYPGLPSRLERELKQLHLERVLKVCFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JR13</accession>
    <name>A0A8J5JR13_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027690">
        <property type="protein sequence ID" value="KAG7162585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JR13"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="250" mass="27211" checksum="E6D56E40ACBF34A1" modified="2022-05-25" version="1" fragment="single">VILVTVTVVAAMPKKPTKEFPKKYNPVLHSIKDTYSVYSHTLDEDLVVPAAKPFAYALMAPSSYNAYFEQEPHDPILPPEGSTYTRVSEVTEGERLVPPPEDTYSSHSGIGLRDMTPPPVSPMTPASQGSYLSYDDNAQDPLEAPELSSYAQTPSDKPGLKELASLVAMIHALPHTSSYSEFSPSGVSQEGGDILDLILRPPSAQEQPVPLHNSYSEISIDQPTYMNEQITTEAVTNIPLPSLSFLPPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRV3</accession>
    <name>A0A8J5JRV3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Metalloendopeptidase</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nas-4-L1</name>
        <name evidence="14" type="ORF">Hamer_G001909</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRV3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035342367" description="Metalloendopeptidase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="13">
        <location>
            <begin position="107"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="12">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7160615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="400" mass="44802" checksum="741B629250C9F07C" modified="2022-05-25" version="1">MLWAASWWVVWAAMRAVLCAGVVTGGVAAGGRSSDPNMDTDIPGSPLSPADFENSAEMIHDTVDTNSQADPIELAGLFQGDIMLHHGDILLDLPHGAAKGHHRSGRSALIDVHRRWPNGIIPYVISQTYGETERGTIAKAMSEFHAKSCIRFVPRTIEKDYIHILKGDGCSSSVGRAKGAQQVSLGPGCLYVGIVMHEFMHAAGFWHEQSRSDRDNFITINKLNVQDGIVGDALWAIRLRQRTEADYYTQRCRQRNRPKTRVHQGKCPMLFSHAPEVLVDALTEECADNVKHCQMWADMGECELNPTWMYVSCRKACRQCVNPTTSCEDKNKYCKSWSKTGQCHSNKIYMLVYCKVVWTVLTLRTASPLYRSPVFTPFYKERCSGSTANRSRKYCVAHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JS25</accession>
    <name>A0A8J5JS25_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pro-resilin-like 173</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G029680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030534">
        <property type="protein sequence ID" value="KAG7161013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JS25"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7161013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="313" mass="34375" checksum="A00E11B8D53A38F8" modified="2022-05-25" version="1" fragment="single">LSHSLPDAVEDIIRQRRHEESQTVATTPVGTYSKQLPIVVQRSRTLPQLPARREGRLLLGNDYGHEESRDGLQHPGHLYLLASLKGRSRTQAKDITDHWKVNIDKVYMLCFVQKLFALVAAGICQARSTAQPLLLGSATSCLSYNAQPSPSIAAMFPDYMSHDPKCNAAGCVICRLVAAAFARPDPQYSSPTPAYNPCPSYNAPAHPRPSYSAAPAYPDVNSPQYNSQYAVRDDYSGNDYGHEESRDGYNTQGTYSVLLPDGRVQRVTYYVDGDSGYVAEVTYEGEASTQPTIPPQHSYRPAPASYTPAPSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSN5</accession>
    <name>A0A8J5JSN5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sex determination protein fruitless-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fru-L1</name>
        <name evidence="5" type="ORF">Hamer_G007361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSN5"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF98">
        <property type="entry name" value="PRE-LOLA-G, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10523">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="BEN" evidence="4">
        <location>
            <begin position="210"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7161726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="528" mass="58882" checksum="B385E2F7448F3722" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSY7</accession>
    <name>A0A8J5JSY7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tigger transposable element-derived protein 1-like 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIGD1-L29</name>
        <name evidence="5" type="ORF">Hamer_G002813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSY7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7163602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="532" mass="60610" checksum="4679D8927CCE62B8" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JT48</accession>
    <name>A0A8J5JT48_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Endonuclease-reverse transcriptase-containing protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G014162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JT48"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061343">
        <property type="term" value="P:cell adhesion involved in heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007508">
        <property type="term" value="P:larval heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF21">
        <property type="entry name" value="PERICARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="133"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="656" mass="76427" checksum="7FFE89F201FF2A86" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTN5</accession>
    <name>A0A8J5JTN5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G006419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7159009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTN5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="173" mass="19559" checksum="AB9D3FDDAFA45C8F" modified="2022-05-25" version="1">MNTMGGTESLLCCCSSKGRCFLSLQSKINSGYAGGSSQFVVLSLCVTNHYKFQRVNFLFQTIDADPEELVSELVLYHKVLQYRILDGNGKPLPLNMVDYGAKFMHELYTFINQQNRSAEAVSKVDEVKERCAGLLIEALKQVEGRLPAFARLNVCHSKTFHCSTFEVKKKRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTR0</accession>
    <name>A0A8J5JTR0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peripheral-type benzodiazepine receptor-associated protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Tspoap1-L2</name>
        <name evidence="2" type="ORF">Hamer_G014222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTR0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="64"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="371" mass="43101" checksum="134E5FA496429214" modified="2022-05-25" version="1">MGDQCVNDEMCVKAFSSMFDFHVTINDIRQFKPDFVQKIYTCFIRDFGACLEQIHQTRIKREAKEKMLENCKQLQVKIGNVKLENAENQIRVEQELERIEEEKNKLQKCQDIRLTLKSQMEALKMDISTLITAKKDAELEVIEGKERTKVLSSQVVQVTEHQEIQERDSKVASHQSVNQEKRERLTELKHLVQTSNATVEVLNNQLLVMLQDIQQEVTKNKEIQTSLSQLDQDKAALLEGTEDNTMQIQHLTEQLASRQGKVSQMRQSWNLKQESIIEDLNQLKLVLEQVRQSRTEEEIVSQEMETERMRIMQDIQQLNGQTANIGRIIAANYKKIIDTIEKHNNDLQVSLADLAQCMEQSRVKNPEKLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTU2</accession>
    <name>A0A8J5JTU2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase suppressor of Ras 2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">KSR2-L1</name>
        <name evidence="3" type="ORF">Hamer_G014328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025553">
        <property type="protein sequence ID" value="KAG7164192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTU2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF253">
        <property type="entry name" value="KINASE SUPPRESSOR OF RAS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="362"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7164192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="648" mass="71473" checksum="A7B381FC74DB8279" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV67</accession>
    <name>A0A8J5JV67_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032273">
        <property type="protein sequence ID" value="KAG7159774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JV67"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="161" mass="16803" checksum="66A13A8893D83291" modified="2022-05-25" version="1">MCSLFVPTESHQPTEVPITTTTEEGVSLVVSLGLGYFGCRKRKKKDDDNGSDSGRPLNFAPALSTTADMFPWPSTPSHQQPSGSPYSTPAAGQPPSFPSPFGGESSRSSNPSGEPQVPHCSQGRGGHTQKASPQGPQKQTELPVVSLPRPASPDPGPSHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVS7</accession>
    <name>A0A8J5JVS7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-(apurinic or apyrimidinic site) endonuclease 2</fullName>
            <ecNumber evidence="3">3.1.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">apex2-L</name>
        <name evidence="17" type="ORF">Hamer_G022938</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010028174">
        <property type="protein sequence ID" value="KAG7162028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVS7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="16">
        <location>
            <begin position="604"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="543"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="13">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="13">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7162028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="652" mass="73555" checksum="3D65BE13CE18BF3C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW50</accession>
    <name>A0A8J5JW50_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hAT family C-terminal dimerization region-containing protein 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW50"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="134" mass="15529" checksum="E6C7408DC3151707" modified="2022-05-25" version="1">MQSVKACNLQDIDMDELYEEYGIVEAIINTPEMVDSHSEERYLKLFSKSEVPFTNLKTVSVYIFSISCSNAQTERVFSMTTSARRNERNRLQVDSVKAELQICNFSEECPAMYKKFLANRKLLEMASKGQKYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWR7</accession>
    <name>A0A8J5JWR7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Filamentous hemagglutinin-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fhaB-L1</name>
        <name evidence="2" type="ORF">Hamer_G002824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWR7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="247" mass="27513" checksum="D893821590B2ED60" modified="2022-05-25" version="1" fragment="single">MAATPYRNTMSGQSTKRGQGAWLSFENGLDNYKESQLKKEWWYNVTPENPHLSRRQKRRFKHELKEKNAGKVLQAKIEKQGRKDSKKPQQPAEPKPKPAEKPKKPAVKPEPATAPSPTEPTPAAEKTTAVKPQKEKPARNKQKTSESEKEVPVAAPKPKPDIVTPPAKKTPTAPTPAPKEAPAPLPVKPEPVKEEIKPEPVKEEVKPEPKKEDVKEEKKPEPAKVEVKPEAAKVEAKPEPVKEEAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYB1</accession>
    <name>A0A8J5JYB1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate receptor-like 54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Glrk-L54</name>
        <name evidence="16" type="ORF">Hamer_G019872</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022770">
        <property type="protein sequence ID" value="KAG7166092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYB1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="97"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7166092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="521" mass="59596" checksum="32414AD0CDF00623" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0T7</accession>
    <name>A0A8J5K0T7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Tmem165-L1</name>
        <name evidence="7" type="ORF">Hamer_G017176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0T7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7167266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="78" mass="8027" checksum="8B986C1CEB5FF64E" modified="2022-05-25" version="1">MTFLAEWGDRSQIATVVMAAREDVSGVIVGGLLGHFLCTGLAVVGGRIIAARISIRTVTIIGGITFLIFAASALIIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0Z2</accession>
    <name>A0A8J5K0Z2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020459">
        <property type="protein sequence ID" value="KAG7168167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0Z2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1018" mass="114028" checksum="FF32DC76A3790BA1" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2A5</accession>
    <name>A0A8J5K2A5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ADP-ribosylation factor-like protein 8B-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">arl8ba-L</name>
        <name evidence="12" type="ORF">Hamer_G019429</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024443">
        <property type="protein sequence ID" value="KAG7165238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2A5"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008089">
        <property type="term" value="P:anterograde axonal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000247">
        <property type="entry name" value="ADP-ribosylation factor-like GTPase 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7165238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="186" mass="21195" checksum="4CDD2C76D9CE5DEB" modified="2022-05-25" version="1">MLALINRILDWFKSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKITKGNVTIKVWDIGGQPRFRSMWERYCRGVNAIVYMVDAADPEKIEASRNELHNLLDKPQLAGIPVLVLGNKRDLPNALDEKGLIERMNLSAIQDREICCYSISCKEKDNIDITLQWLISHSKSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2U9</accession>
    <name>A0A8J5K2U9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G024270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016397">
        <property type="protein sequence ID" value="KAG7169472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2U9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="88" mass="9999" checksum="65A907788389F1FE" modified="2022-05-25" version="1">MSRRVTTRDDIAAVIALYKANHVLREISAQTGVALRVVQNLVKRFRDLGEDELPAHYLSLVGLNYCLHGHLRLFLNKFGPIPHSQHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3T0</accession>
    <name>A0A8J5K3T0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 2 subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Hamer_G012281</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3T0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000795">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7170057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="305" mass="34582" checksum="E4BBB2E2CEBFCA31" modified="2022-05-25" version="1">MPLFCRYYAQKYPEVDDVVMVTVRSIAEMGAYVHLLEYNNIEGMILLSELSRRRIRSMNKLIRVGKTEPVVVIRVDKEKGYIDLSKRRVSKEDVERCTEKFAKAKAVNSIIRHVGELLDYTAEEQVEELYHECNLNEDTRTVLLTQIQRKLQSQAVKIRADIEVSCFEYEGIDAVKSALRGGIAQSTEEIPIRINLIAPPLYVMTTQTTEKQDGLRALEGAIEEVTSKITSFGGTLTVKMAPKIVTDVEEADLARQLEKAEEENREVGGDDDDEEEEVGMGELDIDSEGEEKKEDKQDGEEVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4I8</accession>
    <name>A0A8J5K4I8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aquaporin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Aqp-L</name>
        <name evidence="10" type="ORF">Hamer_G026105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018288">
        <property type="protein sequence ID" value="KAG7169137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4I8"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048878">
        <property type="term" value="P:chemical homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000009">
        <property type="entry name" value="aquaporin-4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7169137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="260" mass="27452" checksum="28EAED9823D71722" modified="2022-05-25" version="1">MGKIKDMRDYVGKAELRELDLWKAVAAEFLGTMVLVFVGTSSCLNGWTEGYAPSVVQISLCFGITLATLAQALGHISGCHVNPAVTCGMLVARHISVVRSLFYIIAQCAGGLVGSAILLGVTPAERQGSLGMTSINPAVNVGQAVGFELLFTFVLVLTVFSVCDERRNDVKGSAPLAIGLSVAACHLAGVPITGASMNPARTFGPAVVAGLWENHWVYWTGPILGGMMAALIYTYLFRAPKITPSYDINLENCNKGGNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4K6</accession>
    <name>A0A8J5K4K6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G021712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017414">
        <property type="protein sequence ID" value="KAG7169306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4K6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="186" mass="21373" checksum="470931CB926E4CDD" modified="2022-05-25" version="1">MDFRLVRILRDTDVQEILSGTPRRLGTHIRFANHYQILQDGPLAEGEGVLLGYDLPEDGVHCVSLYRCLDGRYLYHDSTPRPMHHLVRRFMQIHNIPQEQVTIVDAIVQGPVSHTCAYHALTFLDIVSSVVIEDSWLVVKHYKEAIRSFFPDELVVLRVFRMIGEFHNTINLTATSIYDSVLPPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4L4</accession>
    <name>A0A8J5K4L4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster assembly scaffold protein IscU-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">iscU-L1</name>
        <name evidence="2" type="ORF">Hamer_G026233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018064">
        <property type="protein sequence ID" value="KAG7169182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4L4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="1">
        <location>
            <begin position="52"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="128" mass="13502" checksum="D73AE5073B24213F" modified="2022-05-25" version="1" fragment="single">FGVFRSTLVGNTAPVVVVNIGHLDNVVVCVVSCKMALLRATSRSLPFLAVRTTQVIDHYENPRNVGSMDKNDTTVGTGLVGAPACGDVMKLQIKVDVDGMITEAKFKTFGCGSAIASSSLATEWVKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5J3</accession>
    <name>A0A8J5K5J3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5J3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035238115" evidence="1">
        <location>
            <begin position="16"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="99" mass="10863" checksum="F348CB06157DBA33" modified="2022-05-25" version="1">MKIMLVFLLVAVAVALPTADPDPQVLLYSHPYSLTLKTIDTKTPAATVPLTYTYPGLGYPATYSLPRGYLGYPYSYPYGYPYGWQVVANPAKEPAVEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K9L0</accession>
    <name>A0A8J5K9L0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G028250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012282">
        <property type="protein sequence ID" value="KAG7171391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K9L0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="32" mass="3725" checksum="72B35F7A6B22AF1D" modified="2022-05-25" version="1">MYPWGFLQHYCLAPCHLMLIFICSSPGLMLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KBA9</accession>
    <name>A0A8J5KBA9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G025741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017572">
        <property type="protein sequence ID" value="KAG7169273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KBA9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="294" mass="32743" checksum="1BCD8F26ED8AE969" modified="2022-05-25" version="1" fragment="single">TLPSSGAGSYRIQERNPTVFWAEVDCFLGQNFSVFGARILPFAGAESCCFRERYPTVSLVRILAYSGAESYRFLGQNPTVFWGRFLPSSRAESYRILAHNPTVFWDRILPYSGAESYHILGGIRPFSGAKSYRLWGQNPTVCWRRNLQFSGAIFYRLLGQNPSVFWGGILPYSGTESYLILRRNPTVFSGGILPILPSSAAESYPILGRNLTLLWGGIITLFWGAILRYSGAESYPILGQNLTIFWGGVLPYSGAESYRLLGRIPSIYEGGILPYSGAESYFLLGRIPTVFWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KBB4</accession>
    <name>A0A8J5KBB4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012575">
        <property type="protein sequence ID" value="KAG7171237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KBB4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="107" mass="12025" checksum="9815620C91782B84" modified="2022-05-25" version="1" fragment="single">SPSLTPTPHRESFPHSNTSVSPFLTPTPHRESFPHSYTSHESFPRPYTSVSPSLTSTPHSKTFSHSYTSQRVLPTLQHIATNVKPLRVDQASSSDLYPIGENCRFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KEH1</accession>
    <name>A0A8J5KEH1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 525-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Znf525-L</name>
        <name evidence="9" type="ORF">Hamer_G027510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013431">
        <property type="protein sequence ID" value="KAG7170823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KEH1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000671">
        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7170823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="193" mass="22441" checksum="466F4E067C779933" modified="2022-05-25" version="1">MKEHGLEEWHYFGSFCTKTFAKGKHYTTPQDTRENKALPVDCVMQIIAGGQVTQAHVKPQSRTPEKEHKCSKCPKSFSTKEYLQAHLKVHGGKKYKCETCGFLCSSMFNLETHRKKHLGDKPFKCELCEKTFVRETSWTTTWNKFIRIKRASVKCVVNYFRKDVLKRHLAAHNNETYDEICGKKFSEGPFCYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ML66</accession>
    <name>A0A8J5ML66_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative prune 2-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Prune2-L3</name>
        <name evidence="2" type="ORF">Hamer_G021222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041527">
        <property type="protein sequence ID" value="KAG7155479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ML66"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="178" mass="17999" checksum="DD0D7B9720A90F33" modified="2022-05-25" version="1">MRGESGEAIVGGGGGVVSDEVATRDGREVKGSFSPPLSAAASQVSLAPSDLTTSDPDLAGSSAYFSAASSRPPSSSQMSVITDLDLTAGSSLSSSAASSRPPSSSGLATPDLTLPAPEDYTTETVEFPTSPRALKIDRLKCNGVCFVESEEAMEGLHSATPNLLTPTYKPGVLVSSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLR0</accession>
    <name>A0A8J5MLR0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox protein MSX-2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Msx2-L2</name>
        <name evidence="11" type="ORF">Hamer_G019273</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Msh homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040280">
        <property type="protein sequence ID" value="KAG7155857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLR0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050674">
        <property type="entry name" value="Msh_Homeobox_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338">
        <property type="entry name" value="HOMEOBOX PROTEIN MSX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338:SF0">
        <property type="entry name" value="MUSCLE SEGMENTATION HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="187"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="189"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7155857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="287" mass="32354" checksum="EBB2BB8743890340" modified="2022-05-25" version="1">MVICFPLRQRSRRSLVVLWDGWRQPASHVMEAQDAAQDRPKLSFSIDSILKHESSGHRASTSPTVEDDHLQEQPKIRPVPLQLLTEATTVSRTATSPLSSLLALTPESSPERPTSTASASSECSTSSQNSQQSTLCSETPLVSRQAARIFPGQWSSLRSHPYLPRLPLTTAEGTPVLPRSITLRRHKPNRKPRTPFTSEQLLTLEKKFREKHYLSIAERAEFSASLNLTETQVKIWFQNRRAKDKRLKESEMERLTRPLYPSYGGFLSFAGQLPSLHLRQPLVPLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLT5</accession>
    <name>A0A8J5MLT5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">F-box-like/WD repeat-containing protein ebi-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ebi-L</name>
        <name evidence="8" type="ORF">Hamer_G026442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat EBI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039804">
        <property type="protein sequence ID" value="KAG7156154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLT5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="430"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="481"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7156154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="557" mass="62471" checksum="C6E4CEE878C51764" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMY3</accession>
    <name>A0A8J5MMY3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cyclic nucleotide-gated cation channel subunit A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CNGa-L</name>
        <name evidence="13" type="ORF">Hamer_G019300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038152">
        <property type="protein sequence ID" value="KAG7157072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMY3"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000002">
        <property type="entry name" value="Cyclic nucleotide gated channel alpha 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000001">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000030">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.300:FF:000002">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032406">
        <property type="entry name" value="CLZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF11">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16526">
        <property type="entry name" value="CLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="356"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="575"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="505"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="631"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7157072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="670" mass="75376" checksum="865DE96E9B626583" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNC1</accession>
    <name>A0A8J5MNC1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NFU1 iron-sulfur cluster scaffold-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Nfu1-L1</name>
        <name evidence="3" type="ORF">Hamer_G027320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036579">
        <property type="protein sequence ID" value="KAG7157868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNC1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU C-terminal" evidence="2">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7157868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="167" mass="19286" checksum="CB3C127AB422D921" modified="2022-05-25" version="1">MDDEEAEWRTIKPEAFAVIMDFFASGLPVIHQVDQRENDHAGCDDEDDETVAMIKELLDTRIRPTDDEEAEWRTIKPEAFRCHHGLFASVFQLYIKLTKERMTMMMGSCTGCPSSVVTLKNGVQNMLQFYIPEVAEVVEVKDVEDDLIEEEFNKFEKELNSEQTKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNS3</accession>
    <name>A0A8J5MNS3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">lysozyme</fullName>
            <ecNumber evidence="2">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lysoz-L</name>
        <name evidence="9" type="ORF">Hamer_G008949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNS3"/>
    <dbReference type="OrthoDB" id="6337871at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16890">
        <property type="entry name" value="lyz_i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.530.10:FF:000019">
        <property type="entry name" value="lysozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008597">
        <property type="entry name" value="Invert_lysozyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11195">
        <property type="entry name" value="DESTABILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11195:SF22">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05497">
        <property type="entry name" value="Destabilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51909">
        <property type="entry name" value="LYSOZYME_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="4" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035180277" description="lysozyme" evidence="8">
        <location>
            <begin position="25"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="33"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="38"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="92"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608597-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7158301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="174" mass="18400" checksum="1691BCA285BAE0D8" modified="2022-05-25" version="1">MSLVKTALLGLTAAIMVIMVCSQAAENVVSSNCMGCLCEASTRCNASAGCTTPYPGGYFCGAFLLSWAFWADAGKPVIKNDDPEKKGAFENCAFDLPCAAKAVRQYMKKFSAGVQGVNNDCNGDGKVDCVDFAFMHMLGGFGCHDSSLLTTDFYKRFDTCWKVVQAATVGGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNZ6</accession>
    <name>A0A8J5MNZ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G020681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035785">
        <property type="protein sequence ID" value="KAG7158077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNZ6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035313606" evidence="3">
        <location>
            <begin position="19"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7158077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="383" mass="42257" checksum="02A0BB7DFA6772AE" modified="2022-05-25" version="1">MRTTGLLLLALVFASVHADDDDMVVSYLINLKVLEIREVMQESSTDDRNHSIKVSLADHDPIPNLRSWTLIIIGNERKVYTQEAGDSQTELEFYGDINVLKNVFVLGNDKSNNTVAVYYGIMNITMTSRLAWVGDAYHTGGASLRVDTGDLEEVEAGIKVCRKEHSPCYFIGVPLPEDIPRCYASTDESNPIKVCDETITKFKEIREPVHLERSGNNLTVHVTFSTTPTKVEVLVFDVNNPTNVLSPENYQCQAMNEPRQVHCMQQLVAADHIQTLMVLVVGLDDNGYVLESSFAIYGAPYITLLSSLVPYLTLLSSLDTPSEDKTGLIVGSVFGVLCGVAIIAFIVCTVMKKKKKKGGSSATRVAGEYERTATQEPPSREEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPI7</accession>
    <name>A0A8J5MPI7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lifeguard 1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Lfg1-L1</name>
        <name evidence="2" type="ORF">Hamer_G006293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPI7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="215" mass="24270" checksum="8BD3AF43D9813AF4" modified="2022-05-25" version="1">MSGFSQLPPAWNNPSASPSAPPLDPSAYSQLPFPQHPHSQQIYSQQPYPQQPNPQQPNPQQPNPQQPYSQQPYPQQSYQQQQGQPYSQQMYPQKPYPQQAPSTQVVVEQRDPSPVMLHTQQPPIIVQERVVINNRVGSKLVFLTRITSTVYSTCVLTSLTRVHVGSPLIGRWWVQEWVRTCCSAWQRVEASDTITVTTITATTGISVVLVSREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPL5</accession>
    <name>A0A8J5MPL5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger protein 536-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Znf536-L3</name>
        <name evidence="7" type="ORF">Hamer_G011494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPL5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7158812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="292" mass="32635" checksum="792DCEF3E354ED14" modified="2022-05-25" version="1">MNKHLKYRGTHQTLRGPDVNEGYAEQQMLAPHWQQQQQTAVTLQGATLPSPRTTHIFQDYGNQGHHSGQQLTANAQQQTSKEHIPGFTPMEHKIIHEVKLKMDSAAPKQQEIEAHAGDALHLMRPLIDPITGQEMEATQTQASEAGDALYNFTGNFSGASASAQGQATPTPALKEAMECHYGDCKCIKQEGQNDESNNPPKPCSGKHCNCTCKTHKIVIAHKKDNVGKIHKCPHCDFTSKRSDNVRRHMLRHTGERPHKCPHCDFSAKRPHSLKKHIENVHNKDLRTDGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQH6</accession>
    <name>A0A8J5MQH6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7160043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQH6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="38" mass="4029" checksum="D1BCD2940B9D9994" modified="2022-05-25" version="1">METISGSKTVRQQRQQDVGRTAVVGRAALSAVEGLQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQT4</accession>
    <name>A0A8J5MQT4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Origin recognition complex subunit 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Orc6-L</name>
        <name evidence="3" type="ORF">Hamer_G021659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031456">
        <property type="protein sequence ID" value="KAG7160281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQT4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054113">
        <property type="entry name" value="ORC6_cyclin-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020529">
        <property type="entry name" value="ORC6_met/pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13394">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13394:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21913">
        <property type="entry name" value="ORC6_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC6 second cyclin-like" evidence="2">
        <location>
            <begin position="73"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7160281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="189" mass="20443" checksum="8DFDC55B3CACAA6F" modified="2022-05-25" version="1">MEVAALHTLALKLGLTSTNTLRKAEELIRLLAVRGGSRLSLSMSGKAVICLEMAAALTGATVDKVSGYDDSTDGNKGDIDTSLPVYQTAAVVAACKVMNIKVDKRRLFESSCSKRAVYQKLVDVLSVKNNKKRTRTLLDMVEDNLRDCSPEKRSKGTEDGEEEEDGGGDKGTDFEDWKKKILEAAAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQX6</accession>
    <name>A0A8J5MQX6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamate receptor 3.1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Glr3.1-L2</name>
        <name evidence="11" type="ORF">Hamer_G001837</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQX6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="90"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7160550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="378" mass="42465" checksum="9137B5E3ACBF0A6B" modified="2022-05-25" version="1">MAMFTEEVRVVLTVVDRPPHLYVKEQDDGSLSVSGPMANVLHVMASSLNFTYHLIRPVDKIYGSELDNGTWSGQPEIDPWGFLFPLDSVVWAALLASLVITWLAMVVIGSNNNEKGVGCFTWITDLFLEHLRVALRQDFCLEQRHGSERMLVLGWMVVTMMVTWSYSGNLVSLLAVRYIPKPLQTLRDLLDSSVTLIMTRNDIFRNFLLTVKSGDLKGLGNLYKVGRVKYQLSKTFPDVMENLVTKGHHVLFSPGLGLDRLAANYFANTGRCDFYKMRMALFPITHCIIGLKGNLLVRAMSYRVRAILESGLYDHWLMSSIPFSTVCRHAPSIITVREPLAINNLWGMLVLLGAGLLLALVTFCLELYVDKRCSDGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR39</accession>
    <name>A0A8J5MR39_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030679">
        <property type="protein sequence ID" value="KAG7160805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR39"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="347" mass="38576" checksum="25F4FED5F17C9C53" modified="2022-05-25" version="1" fragment="single">IEKNGSGSRQITKYKSHRRPTGPGTLRDASTRDILPDVFKQESARLRTLSEVPGAPVSCTPHTTFNQCRWVVVFKELLQYSEEKLLEELRVQKGVTMDSEAYPASSSECDPVPTRERYPPHPHDKVCFVETRSTALKSVSSHEDSYVQVLSRHEDRRSVDVTSTRESSVPVLNLASTPDSVDEAGTSATLHHSSTHRSGTTKISEKCYRGSSESLDVDDHLAKVSMCRGLIANWEELQLYLNKFSPICICLQETMFGVYDRLPPRGYSDFYSSQNQEEMPHGDTAILFSDKCGVPYILMANDGSSVAAPEEVAELFSTTYAGVSSMTARSRTLDLGVGRGETYNILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRD2</accession>
    <name>A0A8J5MRD2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ATP-dependent zinc metalloprotease YME1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ymel-1-L</name>
        <name evidence="18" type="ORF">Hamer_G023491</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030714">
        <property type="protein sequence ID" value="KAG7160789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRD2"/>
    <dbReference type="OrthoDB" id="6362170at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 18" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="336"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="187"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7160789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="747" mass="82276" checksum="082819F9087EBC37" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRF1</accession>
    <name>A0A8J5MRF1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myocyte-specific enhancer factor 2B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MEF2B-L</name>
        <name evidence="7" type="ORF">Hamer_G016265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRF1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000001">
        <property type="entry name" value="Myocyte-specific enhancer factor 2A homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="MADS-box" evidence="6">
        <location>
            <begin position="49"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7161213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="138" mass="16011" checksum="244114E2F562E2AF" modified="2022-05-25" version="1">MKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDKVLLKYTEYNEPHESLTNKNIIEVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNNDIVEVINISCQQSFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSG3</accession>
    <name>A0A8J5MSG3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allatostatin B2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSG3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="166" mass="18825" checksum="5A307B0090197546" modified="2022-05-25" version="1" fragment="single">SLTLPPPQAAEDKRTNWNKFQGSWGKRNNWRSLQGSWGKRAWNKLQGAWGKRSEDDNGDDLYDETNLEEDLAGNEEQVSPLALARLMAAAPQKRGWTLWGKRPDNTRVSPRSTNWSSLRGTWGKRSADWNKLRGAWGKRASDWGQFRGSWGKRAPDMMSVAAPNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUX7</accession>
    <name>A0A8J5MUX7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoplasmic reticulum-Golgi intermediate compartment protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ergic1-L</name>
        <name evidence="2" type="ORF">Hamer_G025552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025287">
        <property type="protein sequence ID" value="KAG7164541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUX7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF36">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="1">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="142" mass="15883" checksum="52E94D7E00FCDFBB" modified="2022-05-25" version="1" fragment="single">MSMMSQGLHLLEGCGQVLRLVVVRLDIYRKVPKDLTQPTLTGAVISVTCITFMLILFTSELLHFLSGEIVSELYVDNPGESTDRIPVYIKISLPRLKCDYIGLDIQDDLGRHEVGFVENTNKNPIGEEGCLFEANFLINKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MV28</accession>
    <name>A0A8J5MV28_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein heavy chain-like 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Dnah-L18</name>
        <name evidence="2" type="ORF">Hamer_G020537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025733">
        <property type="protein sequence ID" value="KAG7164089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MV28"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="725"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="749" mass="84600" checksum="F35560A380714659" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MV63</accession>
    <name>A0A8J5MV63_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sorting nexin-12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Snx12-L</name>
        <name evidence="13" type="ORF">Hamer_G014331</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025553">
        <property type="protein sequence ID" value="KAG7164194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MV63"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06894">
        <property type="entry name" value="PX_SNX3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000002">
        <property type="entry name" value="Sorting nexin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="28"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7164194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="163" mass="18980" checksum="5ED0E0248AC63EE8" modified="2022-05-25" version="1">MADMTNDSTRRLVSKKQTLDDAYAAPANFLEIDVVNPITHGVGNKRYTDYEVRMRTNLPVFKVKESSVRRRYSDFEWLRNELERDSKIVVPPLPGKALKRQLPFRGDDGIYEEEFIEDRRKGLEVFINKIAGHPLAQNEKCLHMFIQEPVIDKNYVPGKIRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MV70</accession>
    <name>A0A8J5MV70_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Fbl-L</name>
        <name evidence="16" type="ORF">Hamer_G017232</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. It is associated with the U3, U8 and U13 small nuclear RNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MV70"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7164841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="314" mass="33126" checksum="2E8C5C15765190AE" modified="2022-05-25" version="1">MGRPDFSPRGGGGGFRGGGGGFRGGRGGDRGGGRGFSPGGRGGRGGFSPGGRGGSGGRGGGFRGRGGSGGRGGFRGGRSVMLEPHRHEGVFIARGKEDVLVTKNMVPGESVYGEKRISVEEGTEKIEYRVWNPFRSKLAAAIVGGVANIYMAPGSKVLYLGAANGTTVSHVSDVVGPDGIVYAVEFSHRSGRDLVNMAKKRTNVVPIVEDARHPHKYRMICSMVDCIFADVAQPDQARIVAINAQHFLKVGGHYVISIKANCIDSTAPAEAVFAGEIKKLQGDLLKPQEQLTLEPYERDHAVVVGVYRPPKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVA9</accession>
    <name>A0A8J5MVA9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Rpl12-L1</name>
        <name evidence="9" type="ORF">Hamer_G005067</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVA9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="8">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="7">
        <location>
            <begin position="79"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7164677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="170" mass="18312" checksum="459491198E909062" modified="2022-05-25" version="1">MWDMTCGVFTDRVSLSSVCLRCVGGEMAATSSLAPKIGPLGLSPKKVGDDIMKATGDWKGLKVTVKLIIQNRQARVEVVPSAASLVIKALKEPPRDRKKVKHIKHTGNLTLDQMLEIARTMRPRSQAKALSGTLKEVLGTAQSIGCTVEGQNPHDIIEGIDEGSVEVPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVF9</accession>
    <name>A0A8J5MVF9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U-scoloptoxin(01)-Cw1a-like 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G017250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVF9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="302"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="689"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="845"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="971"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7164857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1146" mass="127964" checksum="ACDCB61C3F10961F" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWE2</accession>
    <name>A0A8J5MWE2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAM92A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fam92a-L</name>
        <name evidence="3" type="ORF">Hamer_G005255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7166955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWE2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009602">
        <property type="entry name" value="CBAR/FAM92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21223">
        <property type="entry name" value="CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21223:SF2">
        <property type="entry name" value="CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06730">
        <property type="entry name" value="FAM92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="291" mass="33262" checksum="4E78C3781E33B508" modified="2022-05-25" version="1">MFSSSSNSLNKVHTNQTKFIQERISGVEKHFGRICSATGAYTRKTAKLRDKGDNLSKTLMDYGEVENLNKSLRSALCETADTLAAVQDYRHVEVERLETRVVGEIALYGGICKTAREELKRSFDTRQQEINHKQNLEKTKNRHPRNRQQIVIAETKLQKSTLEARRACQNLEEQMDQFEQRKTELAFHAKALELYTKAYNQISNIEEEEDLEAFRNARDVFDAEFRNALKGDAAARAEVVGAGHGSSLSPVIASSREKKESHRKRDMKKSLEKLQVEDYEEINESTSSEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0C4</accession>
    <name>A0A8J5N0C4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Gins4-L</name>
        <name evidence="9" type="ORF">Hamer_G013482</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0C4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="67"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="8">
        <location>
            <begin position="163"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7170663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="211" mass="24448" checksum="4650997448AB3BFC" modified="2022-05-25" version="1">MSDSEEDIIEGSGDEGEAMTASEVLQKLEEAWITERISPTLERHQSELVDCMLDQINQMTENLKRCKKHDFRLAIHKMEIDRIRYIISSYLRVRLEKIERFAHYLLEKEANTTEESLAVLSPHEVAYARDYISSLESHFQSLVLQHVPENLRTFDAAKMSVKPNMDSYIFLRAKQETQGVDEEVDLEEGSQHLMRYKPISHLLHSGAVTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0T8</accession>
    <name>A0A8J5N0T8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CLIP domain-containing serine protease</fullName>
            <ecNumber evidence="9">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Cfb-L4</name>
        <name evidence="14" type="ORF">Hamer_G021191</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010013493">
        <property type="protein sequence ID" value="KAG7170809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0T8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041019483" description="CLIP domain-containing serine protease" evidence="10">
        <location>
            <begin position="26"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="13">
        <location>
            <begin position="37"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="243"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="137"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7170809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="462" mass="49527" checksum="CC8C8B12B944E99A" modified="2022-05-25" version="1">MWGHTQVSLLLVALVVLATVTSTPAQIIFPETPSDSLCTAHTGDPGHCINIKECPLIHGIYHNTTPVLCGFNGRFPIVCCPHSNGGNTAPIVDISPPAVSFQCGTNPRKSFNLLISSPDEEFILRPDATSSDVAASFIPNRPEGSGIPSRPMGSGIPSRPEESGIPSHADGSFFPKQPEGPRPGIPESAFKDPAAHVARDPPPPPRRPKAAFNVESLAKETFQPSPGGILEDLGDTVPIILQAVGGIIAEKNAWPWMALIGDNDKQGFVTWFCAGALINEQWVLTASHCFLFRAAQVVRLGEHDYNDNGDGAAHEDFKPFINPVCLPWGQESINDQTGKKVTLTGWGDTQFGGKPSSVLQEVEVTIFPFSDCDKSYSTLLGYTRQWPRGIGKETVCAGDRAGGRDACQGDSGGPLVLRNSAGQYTMAGVVSRGYGCGHKDFPGLYANIHEEQYLAWVKKVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N107</accession>
    <name>A0A8J5N107_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G013481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N107"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="340" mass="37740" checksum="794E55EBC45E14A4" modified="2022-05-25" version="1">MKGDESADDEGVEDSCDAVVAVRDVIHGLVVMVVGVVVVERVTFKRFSGHPRVERGSFFGVLLPVTNLPITIHMLNRKASAVVRHLGVDPGSTDAHQEDAAEGALNGTEEAICHLEDGAQLAHYQTHTDGHHTRHGGCQQKTLPDVPHTLDTSATLQALQECVRVYRGRQGTHLRTPPYTDATKRPDIPTRGERITVAVDGIGDQARKVEDSPQHEQPHDEQNAESCPHEIVWKLVKARRFLTETNLWNCGWLRPAMLSTTYIPSTCVDQNVWRTKGLVSMLPNPRICVSMRDRRFLVLLQIEYEGETIIKKTRVLGDNLLKELKSSALVSDGPHNAWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2R6</accession>
    <name>A0A8J5N2R6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tigger transposable element-derived protein 1-like 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIGD1-L50</name>
        <name evidence="5" type="ORF">Hamer_G009553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2R6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF26">
        <property type="entry name" value="TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7172207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="488" mass="55686" checksum="C5EAD06D3393D9CF" modified="2022-05-25" version="1">MKITKSTGASMIKYFQNQVLLKTEKLLVRYLVRQARLNMAVDTRSVKDYARELYIAVARKMGTTEPKPFNASSGWLQRFKIRNKITNINIGGEEASADRAAAREFPPFLHEIMEEGQYSDDQVFNMDESGLFWKKIPSKSFVVKNASKIRGRKMQKERITVLFTTNASGTSKLKLSVIHTARKPHAYKTMDMTKLNVHWLTARKAWMFSTLSLSWIDDCFVPDVKKFCEQQNVAFKILLLLDNAPGHSPLLLDRHPNVKVVFLPPNTTSILQPMDQELICNVKAAFSTKKFKLLNDYTNTREELRNLSDTTTDSKSEEDEDQQLAQQKILFKQFWRVFNIKKAVDFLVESWDQLSIATIHHAWRHVLHGIPGERRSQSVTVAVDLAREACIEKAKLLLSDDPDANRYEIFTTQLLQTMEPYIKVYHDNINTSRQQSITDFFARNSPQPAQASDSDSGDDFEGFVREALTTVSDSDGDSPSNGDSPEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N308</accession>
    <name>A0A8J5N308_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cysteine N-palmitoyltransferase HHAT-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Hhat-L</name>
        <name evidence="7" type="ORF">Hamer_G009662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the membrane-bound acyltransferase family. HHAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N308"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7172301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="474" mass="54961" checksum="5522CDAA7F6887DE" modified="2022-05-25" version="1">MGQGSPGWDRSDVSETTTKAVICRYGSLGSLFINEKISWGPYLPVTLVQDSWFGVRQDQTDLEWFVWIPIILSYAPWGLVHVVLAQLIRKWCPEHLCSFYVVFSVCITVQLIGGVGTALCFIVPSIMFVVLLTRLKLIIWLTWCCLLILFNTQFFINLEICDTDPEGQLRPLPLLTTLLGYCLYLPFLCTGPYMPFTDFQTGLAEPYRTWTLKRVAGVGLQVIRFLWWMGFTQFLLYQFYAPSLHFMPQLMKKMSSWSMAGFVYFLTAFLQLKYVVLYGLPSVLARVEGYDPPRHPRCTLMTYRFSDVWRYFDHGLYRFMLKHIYIPWVGSEPSMVRQLQGTALVFTFVYVWHGVTTQIFWWATINFFGVVAEKIGDHISRMSAYEALESRWLPGAWQRRFHGLLAVFLYVPSLTALVIFISNLDNAKAIGHRIFISGFPQCTLSIFFFMFCLGQCSMELQNWKIRQKIKAKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N370</accession>
    <name>A0A8J5N370_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G027043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011303">
        <property type="protein sequence ID" value="KAG7172406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N370"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="315" mass="35790" checksum="CEB3F7F3F413EA82" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERREEGSGEQQISVQIDSDNESEVADDPDSDHESEVADDLSLLSPQEKQEVAVVVDPMLSAVLRPHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N373</accession>
    <name>A0A8J5N373_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate receptor 2-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Gria2-L9</name>
        <name evidence="16" type="ORF">Hamer_G009625</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N373"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="98"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7172269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="381" mass="42424" checksum="1C3F517BC648ADD1" modified="2022-05-25" version="1">MKFVLDIFAKMINFDYELVPAPGNKWGAPLANGSFSGMMGLLQREEVELAIAPFFVTPPRETAADFSEPVYYDSYAILMVRPEIVNDMSGFLKPFAPTVWLMIVLSLLCMTVAMSRVARYEEVVVFSLPATTTWAKATLWAIQAFSQEGSHWLPRKHGGRLLVSTWLMASLVFMSSYSGILTAMLTVPRVNIPIDSLKDLVAQSDLPWRIEADSFMYNFFLKAEDNLRQGVFSKKAGTFQDCWADRQAIADGEFAAICDRITMMKAMSWDFSTTGRCHLYISREKVYDNGYLSIAFKTKSKYLPAANKIIKTLKMTGHLNKWLADQITNTTQCLKPPSADIGAGISPLSIEAFSGPLLVLLTGLTMGGVVLVAEHLMKLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3L0</accession>
    <name>A0A8J5N3L0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nipped-B protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Nipbl-L1</name>
        <name evidence="9" type="ORF">Hamer_G020331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011048">
        <property type="protein sequence ID" value="KAG7172449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="8">
        <location>
            <begin position="1754"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="887"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1035"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1135"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2083"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1072"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1147"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1161"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2096"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7172449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2135" mass="241776" checksum="7F3F812D34DDECFE" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3Y1</accession>
    <name>A0A8J5N3Y1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3Y1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="119" mass="13179" checksum="96F006819F38F29D" modified="2022-05-25" version="1">MEGHHHWGTSPQGSFTTGRTSPWRVHHHRGSITTVEASPQGSITMEDNHHKEHHHGGIITTGDHHHRKASPHWEHYHRGASPEAEHHHRQSITMEGSSSPQGSITTGEALPQGNITMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4A3</accession>
    <name>A0A8J5N4A3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Carboxypeptidase B-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Cpb1-L3</name>
        <name evidence="13" type="ORF">Hamer_G008664</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4A3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035278848" evidence="11">
        <location>
            <begin position="20"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="126"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7173137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="410" mass="45425" checksum="C1E066BD68BEC989" modified="2022-05-25" version="1">MCWQQVGVFLLAVVTSVASDNYRELTGNQVWKLNQEDEATVQQLVVDGLVDPLDHSGPSTSLRVTPETAGLVKEVLDQAGITYQVIVQDLARYLRDNDVTPLVQVRFGLTAQTCTSLNCSAPLTDNYMTFEQMEYYLAQLNSHPRVSVSSIGKSIEGRDIWMVHINRSGCEGIHAREWISPAVTLQIIHNITHDCSMGRGLEVYVVPMANPDGYVHTWTNNRLWRKNRRNNPDSSCDGVDLNRNWDFDYGVGASPNPCGETYRGTSAFSEPETQALRDAMLQVNSTGTLQMVMAVHSYGQLLLFPYGNPASNPAPQTEEMKQLGIIFANTVKTVHGKNYVVKSSGSFSPASGATDDWAKGVLKTTYSYTLELRDKSSFVLDPDEILPTGQEVLEGLNMVFLALAPEKYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N541</accession>
    <name>A0A8J5N541_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009070">
        <property type="protein sequence ID" value="KAG7173683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N541"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044659">
        <property type="entry name" value="PELPK1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33088:SF105">
        <property type="entry name" value="ESX-1 SECRETION-ASSOCIATED PROTEIN ESPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33088">
        <property type="entry name" value="MUCIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="825"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="863"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="963"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="987" mass="113857" checksum="603782AF65774DC7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5X9</accession>
    <name>A0A8J5N5X9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LIPF-L2</name>
        <name evidence="6" type="ORF">Hamer_G017952</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009070">
        <property type="protein sequence ID" value="KAG7173667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5X9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035203479" description="Lipase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="5">
        <location>
            <begin position="49"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7173667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="374" mass="42601" checksum="B88C787A179F2EDC" modified="2022-05-25" version="1">MKDWTTSLLVFVVVLAVSESRYSNTTTPVNFTSSSTTSSTEHPHTHLNTAQLIQARGYPAEVHRVITPDGYILEMHRIPHGRTAHHAHTVRPNHPPRPHQPARPRGRQAGRSTDGTGSTTSSSTSRNSTRDSKGRRVVFILHGFLSSSADFVMNDPDEALGFMMADAGYDVWLGNNRGNYYGRQHVTLSPEKPEFWDYSWNEMARYDVPTMLSYVRKSSGMEQVYYIGHSMGTSLFFAMMHYHPHINSWVRAMAALAPAGYVYHKYSMAHVLAPFFDGVERELRRRGIMEIFQLTKDNSNKASKMCGPNAITSFMCILMYFISGGPNSNYVDKDVRKTAKELPWVALDYRIQLRDFNHVDFWRRTRVTFCTTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6A5</accession>
    <name>A0A8J5N6A5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 519-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Znf519-L1</name>
        <name evidence="9" type="ORF">Hamer_G003353</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6A5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7174411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="249" mass="28938" checksum="3345F12CC04D3C56" modified="2022-05-25" version="1">MAQFMNPIAEQGGQNNYECVQCWEDFCSNDALKTHTCMAEHIDEKDIKCEEFDESFNSNSDVTQHVTVDEKDIKCEKFDESFNRNSDVTQHVTVDEKDIKCEKFDESFISNSDVTHVTVDEKDIKCEKFDESFISNSVTHVTVDEKDIKCEEFDESFISNSVTHVTVDEKDVKCEEFDESFISNYDVTQHVTVDEKNVKCQESGKSYFKIKKLKKQMAVHTDEKNLKCKVCGKRFYAKGHLKLHMVVHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9K1</accession>
    <name>A0A8J5N9K1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005527">
        <property type="protein sequence ID" value="KAG7175557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9K1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="104" mass="11447" checksum="F6726BCCDCE42262" modified="2022-05-25" version="1" fragment="single">MNIARPGTLAKAARDMFAANNLPDMEFPNDVPSSEIFNFIYKSESTEIQIPTTHEPSTDEPSTHEPSTQEQTTAGIQPEPASEEESMEDSSEDETTTITEQAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCC2</accession>
    <name>A0A8J5NCC2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adhesion G protein-coupled receptor L3-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Adgrl3-L2</name>
        <name evidence="7" type="ORF">Hamer_G008394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCC2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035165644" evidence="6">
        <location>
            <begin position="19"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7177725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="592" mass="66412" checksum="2DB04C7CDD8163FE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCG3</accession>
    <name>A0A8J5NCG3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCG3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="69" mass="8313" checksum="97FE708CC4DD5DF9" modified="2022-05-25" version="1">MMDLLLLLGNWILPLVCSTTRLALRVLLIQTVTQLQRRWRLQRKENLLSDRCCANLRKFDSVLYYYDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCM0</accession>
    <name>A0A8J5NCM0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000325">
        <property type="protein sequence ID" value="KAG7178266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCM0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="359" mass="41591" checksum="1CFB2442C5C3E45C" modified="2022-05-25" version="1">MYRRNYTDKELINDMIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDSSSDEQEATSDDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHGPWKGNDVAEVNRKRAGEKWRRRWRPEDGMRETKIEEDSRTRAGEQKRRGVKGDGERDREVNKDWRIGKEEIKETSSWSVSEEVNDFYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCR6</accession>
    <name>A0A8J5NCR6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tigger transposable element-derived protein 1-like 116</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TIGD1-L116</name>
        <name evidence="1" type="ORF">Hamer_G026671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002521">
        <property type="protein sequence ID" value="KAG7177342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCR6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="203" mass="23507" checksum="264243F24DF590A5" modified="2022-05-25" version="1">MCRPPQDNDPQTLPGHNTEPVSYGDVSLKEFWKSHFNIADPVFLITSAWKEVTVRCLCAAWRPLWPECVLQRDFEGFEELEEEAVVHEIVSLGNSMGLEVDDDDVEELVEEHSKELSTEELLELHKKENETLKWSLTSEESGEEEDKEESRIIPAKDLKDAFFCWSKLSKLAEDYHPDVGSVQKAISVFNDNVMNYFWKFHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ND71</accession>
    <name>A0A8J5ND71_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G008319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ND71"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="89" mass="9743" checksum="88C82FFE42515FB8" modified="2022-05-25" version="1">MPHDIMRAELTLISCPPEIHAHALCSAHMVRPTTMLSIRMAAHNTPVGIYGTCYQSDSLGKGLTRAKICGRGPDLEVTMTRGSDTYTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T126</accession>
    <name>A0A8J5T126_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding protein D-ETS-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Ets65A-L</name>
        <name evidence="8" type="ORF">Hamer_G023821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011811">
        <property type="protein sequence ID" value="KAG7171719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T126"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000343">
        <property type="entry name" value="Ets at 65A, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF304">
        <property type="entry name" value="DNA-BINDING PROTEIN D-ETS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="7">
        <location>
            <begin position="46"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7171719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="199" mass="22308" checksum="F70A1A06968002F1" modified="2022-05-25" version="1">MGYAHNSLGMTKSSLDAHSPHLRQPDPYQMFGPTSSRLASSGSGQIQLWQFLLELLSDSSNANCITWEGTNGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFQGLAAATQPAGADPTAYKYQSDLFMSSYHPTTKLNFMSTHTGIPSSAASGHSMTHHPSHMTSHISSAYPHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T682</accession>
    <name>A0A8J5T682_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate receptor ionotropic, delta-2-like 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Grid2-L17</name>
        <name evidence="16" type="ORF">Hamer_G007008</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T682"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035299220" evidence="14">
        <location>
            <begin position="23"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="247"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7172770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="620" mass="70094" checksum="B24DEA2A99C2DD5C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T8U0</accession>
    <name>A0A8J5T8U0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase-associated protein Rtf1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Rtf1-L</name>
        <name evidence="7" type="ORF">Hamer_G017817</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007950">
        <property type="protein sequence ID" value="KAG7174089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T8U0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="208"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7174089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="560" mass="63388" checksum="E3A942334E50766E" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TI34</accession>
    <name>A0A8J5TI34_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Short stature homeobox protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Shox2-L</name>
        <name evidence="7" type="ORF">Hamer_G025494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011001">
        <property type="protein sequence ID" value="KAG7172473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TI34"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052631">
        <property type="entry name" value="Paired_homeobox_Bicoid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255:SF3">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255">
        <property type="entry name" value="SHORT STATURE HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="40"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="42"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7172473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="165" mass="18636" checksum="3E7FB5E7224D0263" modified="2022-05-25" version="1">MGRTREKSGGEGTPTTPITPPPSQGKREHEAREETSHQKVKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVGVTAVYVGVTVVYVGVTAVYVGVGGCYCRVRGCYCCVRGCYCRVRGCRWVLLPCTWVLLLCTWVLPYTWVQVGVTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJG2</accession>
    <name>A0A8J5TJG2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G014608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010116">
        <property type="protein sequence ID" value="KAG7173283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJG2"/>
    <dbReference type="OrthoDB" id="6367469at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035235256" evidence="3">
        <location>
            <begin position="19"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7173283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="539" mass="59278" checksum="B88298B1A06D0BEA" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJS9</accession>
    <name>A0A8J5TJS9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G025268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009769">
        <property type="protein sequence ID" value="KAG7173463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJS9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="122" mass="13427" checksum="F31A68F7A546EB6C" modified="2022-05-25" version="1">MNDSPARVWLMTSDDLAYDTTPTTTTTTTTLFRSNTTTPFSRTPFSTSGSALTVTHPSTYTRLRLWLTSLLRARIKPSEVVVARGVNQPLLKHDHLIESVLCKPALTGTRLSDSALTEASPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJY1</accession>
    <name>A0A8J5TJY1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vesicular integral-membrane protein VIP36-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LMAN2-L</name>
        <name evidence="9" type="ORF">Hamer_G000217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJY1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035255542" evidence="7">
        <location>
            <begin position="24"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="8">
        <location>
            <begin position="30"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7176999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="313" mass="35722" checksum="C992B6A610D11C2C" modified="2022-05-25" version="1">MMMLNMGLLRSALVISFFSTIYTREWNTHEYMIREHSLVKPYQGLGTSIPYWDFLGSTMVTNNYIRLTADAQSLRGAIWNKAPCYLRNWEMQIHFKVHGRGKDLFGDGFVFWYVKEPMQEGDVFGSKDFFTGLAVVMDTYSNHNGPHNHGHPYISAMVNNGTLHYDHDRDGTHTQLSSGCVSKFRNLDHDTYISIQYVHDTLTVAGVKLPLGYFLGVSAATGDLTDGHDIISLKMYDLSTPDDDILEDRINIMPSASFFEPPRDHVEDPKPSSLTTWKKVVLLVFGVITICGCVFIGGLFYTKQKEQQRKRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKW7</accession>
    <name>A0A8J5TKW7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKW7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="286" mass="31392" checksum="71754C5B591DAF60" modified="2022-05-25" version="1" fragment="single">RPVEWPPRPEPNADQDQPDQVASSAYNDQVPPPVPPRPANYPQASMDQVQQQQTVSQQQQRQQQVTSSSSEMRTVKQSYQVQQHYQQQFSGSQQQYQQPQHQFVQHQMSQQTSSSSQHPPVFSREYPVPVQTNSQPANFGPPGSPFSQPSVPQQRAAQPQYAPQSAAQPQYAPQSAAQPQYAPQSATQPQYAPQSAAQPQYAPQQAAQPQHAQQNASAPPQYAPQNAAQPQYAPQNVAQPRSSPMKAASPQTGRQNATPPPTKVDASENVPGYSSAYTAVQGEWPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLD3</accession>
    <name>A0A8J5TLD3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RWD domain-containing protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RWDD4-L</name>
        <name evidence="3" type="ORF">Hamer_G008245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLD3"/>
    <dbReference type="OrthoDB" id="10045773at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23817">
        <property type="entry name" value="RWD-RWDD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042770">
        <property type="entry name" value="RWDD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21275">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21275:SF1">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="7"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="190" mass="21757" checksum="CC441F0F56AB312D" modified="2022-05-25" version="1">MREEHEEEREVLQSIYEGDTNYCMINETTFQYKYGEEGGSNSFLVEISWGPDYPDVAPTISLDLFYNKHISPSVKQKITAELHDQAKVNLGMSMTFTLFEWLKEAKDELLENHPTEPLVLGVSEITSEVGQISVNDDHGEGKREKKEQLTKAQKRRMWDRQNAAGERSRGYNWVDIVKHLSQTGGSKNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TM36</accession>
    <name>A0A8J5TM36_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TM36"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="78" mass="9317" checksum="ABF3F97347A707E1" modified="2022-05-25" version="1">MLLQQRIKSFALIRLLWQSELVDRSREEWVHRILMMISHNCQLMFFCTIELYFTACVNGFLSYFLAALQELTQVDKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TNF5</accession>
    <name>A0A8J5TNF5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TNF5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7178095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="208" mass="23285" checksum="AB2D37C6E51835BA" modified="2022-05-25" version="1">MVTSSLVVNCVGGLRAALASLHEVYKSKLVSLLESSTETRLNKFESVEAFRLAATLDPRYKLDWCHDYDNEVQDIRDLLTVKYNMAGSVEPTTTDTSPAEPPPMKSNSFFGLANRSSTPRPTPSETEVSLYLNQPCLQEAGDPLATGRPSNLSFPSSPGLQQSTWPFMLHRLLWNDCSPIAGKLFRPEVCNLRDKRFEQLMMIRCNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J6P2</accession>
    <name>A0A8J5J6P2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative olfactory ionotropic receptor IR4-like 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ir4-L18</name>
        <name evidence="2" type="ORF">Hamer_G026942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046274">
        <property type="protein sequence ID" value="KAG7153932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J6P2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035196162" evidence="1">
        <location>
            <begin position="29"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="111" mass="11955" checksum="CC543E5D3FFE78EF" modified="2022-05-25" version="1" fragment="single">FQSPGASQMVGAGRTLVLMAVFLSVAQSLLPSVILEAVAPEVLQAVLVSEWHPRCSLIFLTDDHPSALTVFTEYQSLMGPWGVGLFEVAVDGQDSNVTQAQLSRVVDEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J9D3</accession>
    <name>A0A8J5J9D3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dedicator of cytokinesis protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DOCK3-L</name>
        <name evidence="10" type="ORF">Hamer_G010718</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11872">
        <property type="entry name" value="SH3_DOCK_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.410:FF:000003">
        <property type="entry name" value="Dedicator of cytokinesis protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000045">
        <property type="entry name" value="Dedicator of cytokinesis protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF12">
        <property type="entry name" value="SPONGE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="8">
        <location>
            <begin position="439"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="9">
        <location>
            <begin position="1212"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1598"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1689"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1599"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1621"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1653"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1711"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1862"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1887"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7153404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1936" mass="219294" checksum="3D17390DBA557365" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J9T0</accession>
    <name>A0A8J5J9T0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleolar complex protein 4 A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">noc4l-a-L</name>
        <name evidence="3" type="ORF">Hamer_G009285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J9T0"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="2">
        <location>
            <begin position="301"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7153633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="512" mass="59282" checksum="0D960C9DBC12F67B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDZ5</accession>
    <name>A0A8J5JDZ5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G019242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040280">
        <property type="protein sequence ID" value="KAG7155836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDZ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="136" mass="14359" checksum="32F7612F2481BEBC" modified="2022-05-25" version="1">MSAVYWTTFFVGGKRLVSFEFSTDVLESKMAVTRKTVILNVVRHIEKQTLTGVALDTTSGVALDTTSGVALDTTSGVALDTTSGVALDTTTSGVALDTTGGVALDTTGGVSSRHNQWCGSRHSQWCGSRHNRWCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEZ7</accession>
    <name>A0A8J5JEZ7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042739">
        <property type="protein sequence ID" value="KAG7155178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEZ7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="345" mass="38767" checksum="12D4A09CDFC41EFB" modified="2022-05-25" version="1" fragment="single">KKSPRATAAVGSGSAIRETDTKNDLCGTTVDRRSVAAPETGRRVPLSDSFNGKRIEMRRVENWRENERGDARRILVRHCRVGFFGWRGTRRASAGGRVRRSPCEKLGGRAFTLQKLRNGIFRWNRGPRRMERSGSTPTDRARGSSAAHFVCRIAAIGEHADRSLARLHFRRRGVWSEATRSRVREYGPERRSTKRLVEIQERSSSGIRRASVRAHETTRGHSTPGVERGYASNRRPAESAQETRSLTGRSCPTGVGNIISVWTGDSTDPGRGRRSKRGSRGCGRERRHESETDRTVGTSERFGRRHSGTEDEDASPRRRRSTREEDTPEHGKNTTFANAGRYSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFN1</accession>
    <name>A0A8J5JFN1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041777">
        <property type="protein sequence ID" value="KAG7155403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFN1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="78" mass="8962" checksum="C1C5EE95A35BDE7E" modified="2022-05-25" version="1">MVYEQSYTSANFVADQEARKSAYKVMQMTNYGQTHNSTGQNGSVKRSKKNNNTNSEKTTDVWGSVFQNKQHFVDMHFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JG33</accession>
    <name>A0A8J5JG33_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G029091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037459">
        <property type="protein sequence ID" value="KAG7157512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JG33"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="9498" checksum="726BC2ABC3BAE4BB" modified="2022-05-25" version="1">MEAREGDIKNGLLRALNLNRDVFDTKTWLLYAADAVNRLKLKDTILSKGPNTMSPDYSTPAPWESPPAIFNILQTGTRKADCIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JG51</accession>
    <name>A0A8J5JG51_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein heavy chain 7 axonemal-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Dnah7-L5</name>
        <name evidence="3" type="ORF">Hamer_G027557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040145">
        <property type="protein sequence ID" value="KAG7156074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JG51"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF70">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 2, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="2">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="217" mass="24216" checksum="1CB9E42C7A53AED3" modified="2022-05-25" version="1" fragment="single">MDSSPMTLFGYFNERVKANLHLVVAMSPIGDTFGTRLRMFPSLINCCTIDWFTAWPDDALEMVATSLLQETKLEASLLAHCVTVCKYFHHSIDDLAHRYVTGLEKLKEAKLLITELQEELKLLQPRLVETSANTEALMIKIEQDTIQVERKQELVAADEAVANKKFADAQAIKDDCEKELAKAVPALNAATDALNTLKQDDIRVVKAMKNPPSGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHA0</accession>
    <name>A0A8J5JHA0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Transposable element Tc1 transposase-like 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tc1a-L39</name>
        <name evidence="1" type="ORF">Hamer_G010012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHA0"/>
    <dbReference type="OrthoDB" id="6376364at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13565">
        <property type="entry name" value="HTH_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="130" mass="14806" checksum="1BEDC3843B86BBA4" modified="2022-05-25" version="1">MNHQQEKLVLRGETVALREAGHTIAGIARELGISKPTLQRWWQRWEESGNLLNRPKSGGPRKTTAADDQRIVDAATQSPLTNVVTIREQLQLDISAETVRRRLHEVRIHHRTPAIKEKLDSHPTARLQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIB8</accession>
    <name>A0A8J5JIB8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycine receptor subunit alpha-4-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Glra4-L2</name>
        <name evidence="10" type="ORF">Hamer_G015840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038275">
        <property type="protein sequence ID" value="KAG7156914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIB8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="758"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="783"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="815"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="894"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="9">
        <location>
            <begin position="555"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7156914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="934" mass="103503" checksum="C93A55E6FEAD4741" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIN9</accession>
    <name>A0A8J5JIN9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G011414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIN9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035242325" evidence="3">
        <location>
            <begin position="17"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7158742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="403" mass="44926" checksum="5F5488C94F19775D" modified="2022-05-25" version="1">MKSVIVCLLLTPLVLTLHISYTTLRAYPCQVYPPGRAWAALPTLVSLRPTTTIWSTQIHILDLETRLLACILLMPRKGKLDVFMSTGDCGSTVVNKSIWDIKDFGQDSWTNVEVSVKDSKLKLNVRGTRQSMMTPIPDLPYNLVVMVDNTHTVSVSFGCPRGCYIISELPKSSLKLGRETTFFVLPFRKLKKLKFRVHLKSCFRNEDVGKKDLGLPPLREDQWNVVNFKVEDDKYTVEVNGQQELLVTFATTYCHRSSDFYLSVEGEALWSFNCKPESEMSPVTTTTTTTVTVTPPYTSSPPDLLCESPTTPACDASPPPSSPISIVLLSLHASLLGVCVIVGSYTLYLAWTFSRPHPMTPTTEDLENSDDSSQQMDFSSPVSAESRRSTEGRQRPFSDTSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIS2</accession>
    <name>A0A8J5JIS2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative CDK8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G014850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035946">
        <property type="protein sequence ID" value="KAG7157981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIS2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="72" mass="8309" checksum="7FFD29D88102B702" modified="2022-05-25" version="1">MWRLEWRLLEVEWRLLDVEWSCCRWSGAAGGGVEAAEGGVELLEQQHPGHVQQGGMMNYTNTQQNGNFNQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJB5</accession>
    <name>A0A8J5JJB5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G006744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJB5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="187" mass="20965" checksum="9090B1987855F920" modified="2022-05-25" version="1" fragment="single">KHRSALAEGQRFSSLYISCQNRDGDSDKFFAHENQSCPPSISSMCKLRPGTTSDLVYCLEELIPPPSRDSPTADAVILDGAAILQQANKVDLVWDEYIPSSIKTYTRSNRGKGSRRLEFQRNDDNKIELFSFLSKQVTALETDRQIIVTCHKNILYTQPRDITSLAPCTACSRCSQARLFQGDDSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJL8</accession>
    <name>A0A8J5JJL8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neuronal acetylcholine receptor subunit alpha-7-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Chrna7-L6</name>
        <name evidence="8" type="ORF">Hamer_G006272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJL8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="12"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="226"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7158895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="397" mass="44917" checksum="E0B9B684FC009806" modified="2022-05-25" version="1">MVENPAWRKEDKLREDLLKGYNKHSSSPHRQRHDHCLLQIPGYEHMDRGRQTNIKHELIRPNDVESPKLTWDYKDYGMLSKLHLQDHMVWQPELQLYNNADHTMIDHFQNVKLQVNSNGTVLWIPPAVFRAECPLDYTHWPYDTQICSLYLGSWTYNGWQVNMQLLNNSSLILTARYADKRNSWRVMSSSVRREVTTYPCCPEPYITLHMVITLARTSPSFVCTVVLPACVISVLTLVQFVLPLREPRRLTLGCMSLLLTLLLLLYLATIIPPTATSLPIIVKFYGQTLVVVVVSVCVSASLLRLTDSRHPASTAPPPTLLKTILTGPLGTILFLQRYTDKVGLSGGGGEDGEVLEEALPASYLHEWILVAAAVDRLAALTFVATFVITLIAYVSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKJ6</accession>
    <name>A0A8J5JKJ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G003063</name>
        <name evidence="2" type="ORF">Hamer_G016499</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKJ6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7174169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="103" mass="11608" checksum="251FB4E68138E5B5" modified="2022-05-25" version="1">MQRWSVWASVSAYTRKTVAFTTCLGQGQERSLRRPSRLLKRRSLGHPAEHPPGASVVAEVEKKLEAHSDAAHQDYRVFMLNLQTDLRTTFCPQGILGVGHQDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKL9</accession>
    <name>A0A8J5JKL9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat shock 70 kDa protein-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Hsp70-L4</name>
        <name evidence="6" type="ORF">Hamer_G025379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043674">
        <property type="protein sequence ID" value="KAG7154839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKL9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000012">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1076"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="619"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1085"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1098"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7154839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1110" mass="123415" checksum="80A7A6852BA3BC86" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKS9</accession>
    <name>A0A8J5JKS9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FERM, ARHGEF and pleckstrin domain-containing protein 2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Farp2-L1</name>
        <name evidence="5" type="ORF">Hamer_G005683</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKS9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01220">
        <property type="entry name" value="PH1_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13235">
        <property type="entry name" value="PH2_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000046">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051835">
        <property type="entry name" value="RAC1-GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858">
        <property type="entry name" value="FERM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858:SF5">
        <property type="entry name" value="MOESIN_EZRIN_RADIXIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="178"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="394"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="550"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7157285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="667" mass="76632" checksum="45BB7D799460F089" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JL53</accession>
    <name>A0A8J5JL53_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G005943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JL53"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="70" mass="7486" checksum="0381677B2F368CEB" modified="2022-05-25" version="1">MAVSKQSESRKACPGWRQQCTSCRLIPVMLDAVKPGGENDIVSLPACLFVNLGMTDAEMSPAGILSSLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JM77</accession>
    <name>A0A8J5JM77_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JM77"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="84" mass="9780" checksum="DD8E7D13B8430883" modified="2022-05-25" version="1">MYHLLGTASEEREAMPRPLTRDEREQMALERQRHRSPSAPIYVQPVSYSKVLYKKVDFTPSMIPVHPAQRIQYPQSSYPVVPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMQ9</accession>
    <name>A0A8J5JMQ9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">E3 ubiquitin-protein ligase parkin</fullName>
            <ecNumber evidence="5">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">Prkn-L</name>
        <name evidence="24" type="ORF">Hamer_G001757</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the RBR family. Parkin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMQ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902532">
        <property type="term" value="P:negative regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022603">
        <property type="term" value="P:regulation of anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20340">
        <property type="entry name" value="BRcat_RBR_parkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20357">
        <property type="entry name" value="Rcat_RBR_parkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21382">
        <property type="entry name" value="RING0_parkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000009">
        <property type="entry name" value="E3 ubiquitin-protein ligase parkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000008">
        <property type="entry name" value="E3 ubiquitin-protein ligase parkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047534">
        <property type="entry name" value="BRcat_RBR_parkin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003977">
        <property type="entry name" value="Parkin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054694">
        <property type="entry name" value="Parkin-like_IBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041565">
        <property type="entry name" value="Parkin_Znf-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047536">
        <property type="entry name" value="Rcat_RBR_parkin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22605">
        <property type="entry name" value="IBR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17976">
        <property type="entry name" value="zf-RING_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037880">
        <property type="entry name" value="Parkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01475">
        <property type="entry name" value="PARKIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="21" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035229434" description="E3 ubiquitin-protein ligase parkin" evidence="21">
        <location>
            <begin position="19"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="22">
        <location>
            <begin position="33"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="23">
        <location>
            <begin position="282"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="131"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR037880-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAG7160485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="536" mass="58905" checksum="A37DC5B7A47DE737" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JN78</accession>
    <name>A0A8J5JN78_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RUN domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Rundc1-L2</name>
        <name evidence="4" type="ORF">Hamer_G019209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037402">
        <property type="protein sequence ID" value="KAG7157573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JN78"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17683">
        <property type="entry name" value="RUN_RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058732">
        <property type="entry name" value="RUNDC1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047343">
        <property type="entry name" value="RUSC1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591">
        <property type="entry name" value="RUN AND SH3 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591:SF19">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26030">
        <property type="entry name" value="RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="3">
        <location>
            <begin position="566"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7157573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="757" mass="85578" checksum="D9C5B85FD6E1F948" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNK1</accession>
    <name>A0A8J5JNK1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Programmed cell death protein 2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pdcd2-L1</name>
        <name evidence="2" type="ORF">Hamer_G004105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNK1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052815">
        <property type="entry name" value="PDCD2-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46421">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46421:SF1">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="1">
        <location>
            <begin position="289"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="394" mass="43009" checksum="95573742961DB47C" modified="2022-05-25" version="1">MASKPHQVLLGFVDEQITSRNQQMANFSISKIGGIPDWCISGCEIPICKRCGRRQSLVVQVYSPLEGAVHHRTLYVFACVTQECWNRQHSWTCLRSQVLDLAAVRTSVPPSKCPPSVSSYGGESWFQDEHDWGGNDNDGNGNADNYNLASSSQLYLDNMAKTGGGRICGAVGIVGCEGEGVEATAVIEGPEGDMIAVDTPEQPTTDIPALFQEAAQIDANADVTFSPFFMVSDVEPPEDVAFSEHERELLLRYTHTTGHDFREEEIAAGADGKGDGVYEKDIAIHGDVLLHKFKKRISRSPQQILRYCREEGASPLWLRPPGASDVATKCPCCGGSMVFEMQITPQLVLHLRVPGVQGTPLEFGSVAVFTCSASCWNEKDIVKQEAIVVQCEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQM5</accession>
    <name>A0A8J5JQM5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein Gfi-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Gfi1-L</name>
        <name evidence="9" type="ORF">Hamer_G021087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033419">
        <property type="protein sequence ID" value="KAG7159344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQM5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000148">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000432">
        <property type="entry name" value="zinc finger protein Gfi-1b isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF138">
        <property type="entry name" value="IP01201P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7159344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="100" mass="10800" checksum="677F7A0DD971A9FC" modified="2022-05-25" version="1">MEKGLGSEGEAHKCTVCGKAFSQSSNLITHSRKHTGFKPFSCDLCGRAFQRKVDLRRHKGPSTLTSALSRSTIAPRSPISGHRSTICGRLSPISGHKLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JR88</accession>
    <name>A0A8J5JR88_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Dnal4-L</name>
        <name evidence="13" type="ORF">Hamer_G019398</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027477">
        <property type="protein sequence ID" value="KAG7162676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JR88"/>
    <dbReference type="OrthoDB" id="6506078at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21453">
        <property type="entry name" value="DLC-like_DNAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000002">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 12" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7162676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="106" mass="12255" checksum="B1B335E04E5AD36B" modified="2022-05-25" version="1">MAELRKQESIDDTKKIVHTYPLLRHTDMSEEMKTETMELIVTACEKHQTNNESAARVIKETMDKRYGATWHCVVGEAFGFEVSYEVKNLLYMFFAGNLAIAVWKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRY4</accession>
    <name>A0A8J5JRY4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G002128</name>
        <name evidence="4" type="ORF">Hamer_G002129</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRY4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036271870" evidence="2">
        <location>
            <begin position="27"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7163065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7163066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="394" mass="44837" checksum="273DD2BA499110C3" modified="2022-05-25" version="1">MATRRQCSVLAVWCWCLLARVTLVNTENTVERCVILKDGDLPTRFVPLPVNITTKPLTLGWRLDFTVHNKEEEEEEAPLVCVSIEVKDPDIRLSLFKGKCEGDVVDFHLWNLHEMKIGDWSTVQVTVNDSVINLQLGNNKPKSLTSRSVTLASDTLLQVSHKRSIDLAVGCPINCPAVRGSPASGNRLSTVKELKKRSEKFFFKPGREFARLNFEMKCETPLGHEVRFGDTTLTRDHIEELSPLSKWHYLFLQYDDEQNIFEIFINYRPAKTISVGLNICNTFRNFIVRAEGETFFSFTCDPTSGESQLLPPPDTEDPTVNSLSVAAASSVVTCLVISIVMFTIYLLLRCAGFKFETSYHPEKREKVYKKIFCKKGKTGHEPQRDMEERHQLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JT39</accession>
    <name>A0A8J5JT39_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G011377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JT39"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="122" mass="13604" checksum="0E41E590994B57DA" modified="2022-05-25" version="1">MLPYSGSEPYHLLGTDNYHLRGRNLTIFWRKILPYSGAGSYSILGQNPTVFWGGFLPSSRAESYPILGQNSTIFWGGSYHILGRDPTVFWGKILPSSGAESYRLLGWIPTVFWGTILPSSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV08</accession>
    <name>A0A8J5JV08_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pancreatic triacylglycerol lipase-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Pnlip-L3</name>
        <name evidence="4" type="ORF">Hamer_G014176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JV08"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000033">
        <property type="entry name" value="Pancreatic triacylglycerol lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016272">
        <property type="entry name" value="Lipase_LIPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000865">
        <property type="entry name" value="Lipoprotein_lipase_LIPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035302028" evidence="2">
        <location>
            <begin position="20"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="3">
        <location>
            <begin position="42"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7161609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="525" mass="59335" checksum="D603402898FEBF61" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV84</accession>
    <name>A0A8J5JV84_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glutamate receptor ionotropic, kainate 2-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Grik2-L7</name>
        <name evidence="15" type="ORF">Hamer_G007435</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JV84"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="13">
        <location>
            <begin position="90"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7161789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="292" mass="32588" checksum="403D924F62D5BFAD" modified="2022-05-25" version="1" fragment="single">YSCVIVKDGKWGAPKRTEDGSDGGWDGLVGDILAGKGDVIVAPLDHTLKRSTVVDFCFSFAMLGYKMVIRRPSSQAYTWTSYTREFDSVVWPVVLLFLVGAAFLFYLTGFSPSEVAHFTLGDAFLMTFGSLCNQSTYLKVNSGAARVVMIIIYITNTLFFVHYTCFLISNLTVSSESPPFRNLQGALDDGSYYMGYMKSSSIDAAFQFAPSGIYHKAWQEMVEPIHHTLSPNDALGIQRALEDRYVQMIDETHFLSTYGHNCDLLMLSPTYLKVPTTFAVPKGSPLRRIIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVI4</accession>
    <name>A0A8J5JVI4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil-helix-coiled-coil-helix domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Chchd2-L</name>
        <name evidence="4" type="ORF">Hamer_G017445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7159999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVI4"/>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="3">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7159999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="175" mass="17607" checksum="297B9F04835A7D60" modified="2022-05-25" version="1">MPRRGSAAPRAPPRRAAPPPPPPRAAPPPHAAAPPPPAAAPPPHAAAPPPPAAAAPKQPGLFAQMAATAGGVAVGSAVGHVVGHALTSGGGSSSSNSDQPQQAAPAQPQAYSQPQGYPQYQGYPQQSGPSEPQGPCAWEIKQFLQCAQTQSDVSVCEGFNEALRQCKAQLSQMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWZ8</accession>
    <name>A0A8J5JWZ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ataxin-10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7162929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWZ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="267" mass="30518" checksum="D9BE379F8326F520" modified="2022-05-25" version="1">MLWACQKRLSSYTVAESVDLVDPIISCTQWTFRTADRDNKRVVLTEEDSHQNPLTTTENNNDCHKEVVETPEQDVLSDRNSHSEWKKAHSTLASACVTCLGNMVAANSLTRKLIWPHLLPVLRNNQVKVIVNKLLSLYVNESQYSCFVLFCLELLLCSKDIVEVSWSHLSGEQQLLCLDVLAAILTDTSQKRCEPLSTSTITFLVHFFKVRIYVYIEFNSGVSLGITYAEALAGLLIEMVYTVERRFKAIQFKIIDLKRHPQLRTMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZF1</accession>
    <name>A0A8J5JZF1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin-4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Act4-L</name>
        <name evidence="10" type="ORF">Hamer_G007231</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZF1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000205">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7165401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="374" mass="42220" checksum="F9B9CEEA618D7804" modified="2022-05-25" version="1">MWAEGKIMVMDNGSGLTKVGFAGEDAPRSVFPSIVGRPRYQAMMLGMVKETYVGEEAQKKRGILTLKYPIEHGVITNWDDMEKIWHHTFYNEVLVAPEEHPVLLTEAPLNPKVNREKMTQIMFETFNTPSMYISIQAVLSLYATGRTTGVVLDSGDGVTHSVPIYEGYCIPHALQRLNVAGRDLTEYLINIMTERGYNFTTTAEREIVRDIKEKLCYVCLDFEKEMAASNKSTIFENLYELPDGQVIKIGNERFRCPEALFQPSFLGLENAGIHKYVYNCIMRSDVDIRKNLYANVVLSGGTTMYPGIVDRLLKEITSLAPSTMKVKITAPRERKYSVWIGGSILGSLGPFQQLLITKEEYNESGPSIVHKKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZJ1</accession>
    <name>A0A8J5JZJ1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ube2z-L</name>
        <name evidence="17" type="ORF">Hamer_G002957</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZJ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="277"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="125"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="511"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7163723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="539" mass="58148" checksum="D98503D0924389D4" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZU1</accession>
    <name>A0A8J5JZU1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cuticle protein 7-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Cu7-L1</name>
        <name evidence="4" type="ORF">Hamer_G005134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZU1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF75">
        <property type="entry name" value="CUTICULAR PROTEIN 62BB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035191927" evidence="3">
        <location>
            <begin position="22"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7164729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="323" mass="34651" checksum="98E5A0E875D44DE6" modified="2022-05-25" version="1">MFVLVLAVATVLTASTVSAKAQNYNTLPTITDGAQIVRTDPNLSFNYRYEVNAAETGDQKTHEETLDNGVVVGSYSVLQPDNTLRIVKYRADDESGFKAEVQYQDLQSGSSTSSALQASSGIQGTQRLSTSFGSGISAFRGSSAPSSSSSLSNFIPSSGSTFNIDSSSGSRLGLNLPLDQTSDHLLRTLESLLQTADLLLRTSELLLQASDLPQDLTSDLPLDLTSDLPQDLTSDLPLDLTSELLRRTSELLLRASDLPQDLTSDLPLDLTSDLPLDLTSDLPQDLTSDLPLDLTSDLLLRTSELLLQASDLPQDLTSDLPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0C7</accession>
    <name>A0A8J5K0C7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 4B-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Eif4b-L2</name>
        <name evidence="2" type="ORF">Hamer_G023237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021789">
        <property type="protein sequence ID" value="KAG7167307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0C7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="231" mass="25561" checksum="34E3F0D6901E00BC" modified="2022-05-25" version="1">MRKVFIKFQNTGGRFGGSGSRYDDDRRGGGAGAGGGGFREDNPWRRDREGPRGSSGGESSGPRERPKETGGGGGGGGGGSSGGIFGNAKPVDTAARERQIEEKLRKYDGGGSKDEPRRFERRDDNRDDRRDHRRGDHDDIRDDRRDLRRGDHDDQPSERQINPREGRVERKPHLDDRDRRDQDDHHGGGGGRSSVDNDLPPPPRRAQLPKDDEPVLDTTNKFSGLDLEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2G1</accession>
    <name>A0A8J5K2G1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2G1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="237" mass="27105" checksum="6BBEB3AAB1CABA21" modified="2022-05-25" version="1" fragment="single">MTSRACQHYQYLGTPINLPCTTLRGTVHFLSNHIKERIKPLKWITNRCAGVSVPIDKTIYTAYIRSHSDYRCANYQPLSCHLEKSCIIRSVKSQQASQRTQSSSTPTVHYRKQVHQAALDVAYSRMTYVIEPMHRLPDWVNTTTCELQGILRAINYLMGEYHSGLVIRDSCSGVDLKREKTDTFLIHFMWIPSYIGLHKQNLPALPIPDNASFITTGRVKTPLKKAALQIINEERSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4D6</accession>
    <name>A0A8J5K4D6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">inx2-L4</name>
        <name evidence="12" type="synonym">inx</name>
        <name evidence="13" type="ORF">Hamer_G005091</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4D6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF41">
        <property type="entry name" value="INNEXIN INX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7164694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="350" mass="40362" checksum="541C1D320F330FC9" modified="2022-05-25" version="1">MFDVFGIIRRLLKIDQTRIDNVIFCLHYKATMVILVAFSLLVTNKQYFGDPIDCMVGAINSHTIDMFCWIQSTYTIPSLTGAVVGEEVAHPGVSNHDVVRLPVINGDDGAREQYTIKHHTYYQWVTLVLFIQAGMFYVPRYMWKSWEGGRVKGLVNELNLPILSSDLKRARMTIAVDYFRRNLHHHNLYAYQFFVCELLNFVNVVGQIFLTDSIGHDPTDEIFPKVAKCTFHKFGPSGTIMRHDALCVLPLNILNQKIYTFLWFWFVVVAIISAFGLLYRLATLTSSFRHLLLRGRSRLASAEKVESISRRCQIGDWFILYLLAKNMDPFVYKDFVNDLSEKLGDKEHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6K2</accession>
    <name>A0A8J5K6K2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SARS2-L</name>
        <name evidence="11" type="ORF">Hamer_G012496</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6K2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:serine-tRNA ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Seryl-tRNA synthetase"/>
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    </dbReference>
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        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
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        <property type="entry name" value="aa-tRNA-synt_IIb"/>
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        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
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    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="178"/>
            <end position="423"/>
        </location>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="269"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="284"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="358"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
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        <location>
            <position position="393"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7170925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="454" mass="51463" checksum="2630F587148EDA94" modified="2022-05-25" version="1" fragment="single">EAIVLPADMRNIILNHLQCQCKLRNQLPGKLRTFYTASHKLSDKSTKPQLDYEYLCDPENAHKIDELIKRRKNLGNIWKVHEINKKLKSISPSSQEYEALHMELEREARNIPNKASPHLWDYGDEPKILEFINPKPKFNFTPRELGELGQMLDIMRTENLGNITGSRSYYFKGALADLEQALIRYTVSYLLKMGFTLMSVPDLLYSHVIEGCGMNTRGEHSQVYHIVNPKEDVCLAGTAEMALGGFLKNKQLTLEELPMKLAAVSRCYRAEASSAQEERGIYRVHGFTKVEMFGVTAAETGEESPQLYSEMTQIQKELFSQLGIHFQILDMPLNDLGAPAYTKTDMEAWMPGRGLYGEISSASNCIDYQARRLHITYSNREGIQRFAHTVNGTACALPRTIIALCESFQSYNGTITIPPVLRPYMSGLVNIEPPSIPCKMTWIKQKTYPGKIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K726</accession>
    <name>A0A8J5K726_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Zona pellucida-like domain-containing protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G011525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K726"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
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        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF6">
        <property type="entry name" value="ZYE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7168858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="282" mass="31263" checksum="2B9CB1BA2DA8FC5F" modified="2022-05-25" version="1" fragment="single">MDGILRIGEPLTVMVYLKDTERRLDVAVRDCWAYGEPEFEDPATPSLQMTSSNGCPTRMKLMHFWARTYDTFDTGATLITYTNMSAFKFPDRMQVFLTCNVQICTEHCEDRCIGEPSEPVTFVTTHDIIKVTTPLTPIRLPPPPPPYCRPGSKDPRCRPSITKPICGPGSTDPECRRPLSPACYPGSRDPACKPTTVRPPAPPPLVTQKPICYPGSRDPSCPKPTPPTRRPFTCRPGSKDPRCPQPTTSRPSTPSCYPGSPDPRCPKPTTPFTCRPGSKDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8C9</accession>
    <name>A0A8J5K8C9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zer-1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Zer1-L2</name>
        <name evidence="4" type="ORF">Hamer_G013867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012946">
        <property type="protein sequence ID" value="KAG7171076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8C9"/>
    <dbReference type="OrthoDB" id="5783533at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000394">
        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055142">
        <property type="entry name" value="ZER1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF23">
        <property type="entry name" value="PROTEIN ZER-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22964">
        <property type="entry name" value="ZER1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00718">
        <property type="entry name" value="SIGMA54_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Protein zer-1 homolog-like C-terminal" evidence="3">
        <location>
            <begin position="80"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7171076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="549" mass="62576" checksum="B6B0DF5CD7C2AFA3" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KD47</accession>
    <name>A0A8J5KD47_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox even-skipped protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EVX2-L</name>
        <name evidence="11" type="ORF">Hamer_G020870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the even-skipped homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015974">
        <property type="protein sequence ID" value="KAG7169558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KD47"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052002">
        <property type="entry name" value="Even-skipped_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46294">
        <property type="entry name" value="SEGMENTATION PROTEIN EVEN-SKIPPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46294:SF4">
        <property type="entry name" value="SEGMENTATION PROTEIN EVEN-SKIPPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="74"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="76"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="298"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7169558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="356" mass="38764" checksum="D1F31095EA8FEB78" modified="2022-05-25" version="1">MMGGLEERLSFLVGQQVPVSPPCSPSSGSLTPPSPHHHSTETKDGDSVTEKALEAPAATSTPPPKGTAASQPSAELRRYRTAFTREQITRLEKEFLRENYVSRPRRCELAKELGLSEATIKVWFQNRRMKDKRQRMAVAWPYADPTLAAYLLHAAAATGAYPPYLPPSPMSDSPWVGPPSVGPTPHLSYTAPHMTYTPPSQPPSLSRFAPYPRPQPPMLSPPYTMPADLHAPHPRSPTLPTPTPVLPRPSMCHGHLSACPAYTSPKDACLCGFMYPSLTQNLGHHMPLSCPNLSMTTHKTNSPLSSPSSCTPVSCSSSNSPRQEASPTPTFTKNNSPSTTTPRLFKPYDDEPLARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KE23</accession>
    <name>A0A8J5KE23_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">diacylglycerol kinase (ATP)</fullName>
            <ecNumber evidence="2">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DGKD-L</name>
        <name evidence="16" type="ORF">Hamer_G013473</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KE23"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20800">
        <property type="entry name" value="C1_DGK_typeII_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20894">
        <property type="entry name" value="C1_DGKeta_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000002">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000029">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000001">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047480">
        <property type="entry name" value="C1_DGKeta_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF109">
        <property type="entry name" value="DIACYLGLYCEROL KINASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="75"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="148"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="15">
        <location>
            <begin position="229"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="766"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="862"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="901"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="773"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="821"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="862"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="920"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7170654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="933" mass="102731" checksum="B275A69330591B51" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MGA1</accession>
    <name>A0A8J5MGA1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calcium/calmodulin-dependent protein kinase kinase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Camkk2-L</name>
        <name evidence="4" type="ORF">Hamer_G010658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MGA1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7153349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="322" mass="37027" checksum="E873DF624E57B0F9" modified="2022-05-25" version="1" fragment="single">APTTSESIRRETKEPLDRVHREIAILKKLNHPNVVKLVEVLNDPDEDNFYMVFELLEKGEVMEIPTDSPLGEDKAWSYFRDVVMGIEYLHYQKIIHRDIKPSNLLLGDNGHVQIADFGVCNEFDGKDAFLTNTAGTPAFMAPEALSTSRHKYSGKAADIWAMGITLYAFVYGKLPFHDENIVVLYDKIRSSALSFPPVPFVSDDLKDLISLMLEKIPARRITLPDIKEHPWVSAGNQYPLPSEEENCVLIEVTEEEVQCCVRSIPKLETLILIKCMLKKHSFQNPFKMNVFIKEQFARTGRSHSAPGSYEFYLDRYGLWWWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJH8</accession>
    <name>A0A8J5MJH8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046868">
        <property type="protein sequence ID" value="KAG7153515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJH8"/>
    <dbReference type="OrthoDB" id="6241117at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="421" mass="45788" checksum="68A4AA8A7FA7E645" modified="2022-05-25" version="1">MSRTLPPPLLPDNTAGGGEVCSCPPFECTCGKVGVSMGVEALIPRPSFPHTPLDPYYAHTHQQEDLGHHQRVLDVHRGPADGVRAPQLYRSPAPPAGAFHPPTVNWTPPASLIGDWTMGSIGPRNETMGGEVWITPTLDTGVWCDPPLPHNNPPPPPHHPYTHNYTCDVKLDIQGDPDSIFPFEESFQPQDIFALEQPYRKKGDIPPNIPEATAQKFLQCIDDIIGDCFLDDPLQQQQQQQQQQRSPSTLLDLGSGALTHHHTYSTQHTPTLPHTPTLPHTPTYSTSNPPTSATPNPPTTGMGTSMSLPLQEPSSLQHDDAGRSPTGEAIPQETMEASREAAMTSNRFVFSSPDPDYNNYANETRSYAAHDASTNGSLPSYDVTVYTSSFCVSPSQSQTFTAREGKSDNPFTAFEASSPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJJ3</accession>
    <name>A0A8J5MJJ3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 242</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Tmem242-L1</name>
        <name evidence="11" type="ORF">Hamer_G017643</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC3. Participates in the incorporation of the c-ring into vestigial complexes. Additionally influences the incorporation of subunits MT-ATP6, MT-ATP8, ATP5MJ, and ATP5MK in the ATP synthase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM242 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046276">
        <property type="protein sequence ID" value="KAG7153833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJJ3"/>
    <dbReference type="OrthoDB" id="2378895at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009792">
        <property type="entry name" value="TMEM242"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13141">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13141:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07096">
        <property type="entry name" value="DUF1358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7153833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="166" mass="18213" checksum="B4F7536F7FAA3D75" modified="2022-05-25" version="1">MEGAVNTGCSSQERIIKDTSNKFKYQSAAFLTGIAGVSLLGGFGMTLGMAKKKDPEMFNKGIIGTRELREAGGALALRALGWGTLYAVAGFSVFCFGAWKLMGAKDLQEFRTKAGGILPRIPKNNPPQSRTEFEGLNDLLQYIIDEDERKKHETISKISEPFMNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJX7</accession>
    <name>A0A8J5MJX7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Sulfotransferase domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G023187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045868">
        <property type="protein sequence ID" value="KAG7153967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJX7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="375"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7153967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="508" mass="57538" checksum="0A17441F164D8183" modified="2022-05-25" version="1">MRRGNLRLVTFLAVGVLAWFNLLFLLFRQQQQQLRPEDQEVSPTPHHRPGGEPTNTPQDQEVSPTTTPQTKRQSLPPHPTDTVSLPPHHRPGGESTTHHRHGESTTTQTRRHGESTTTLQDQEAGAPPHHRPGGEFYHHTTDQEVSLPPHHRPRDQEVSLPPHHRPGGESTTTPQTRRRVYHHTAGQVSLPPHSRPDVLLDPNAPVILVADDSKDEDARGPLPALSPLPQALITTYTPTNTTRQSRVHLKPGALANRFLVHSYDHGGGGVVSEALNLLLDEIFFLYQPLYKLGSQGLTRVHLLKKEKTEEGIEWLRGVFNCSFNQRSDLLHEPFLFKSHSVRNTYNNYCHNHQVGLLDCVQLACQQRPLQAMYIVHLSMFHILQLLNMYSSKLKMVVVLRDPRAVLGARRRAATQINLNNPADFKTQASLLCGAMVDDLGVAYQLRQQYPQSVMVLRYEHLLLKPHHVLSYLYDFLGLQVTHHHLNSVIKTLRLDLSEQTLLQITKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK08</accession>
    <name>A0A8J5MK08_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G022122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044612">
        <property type="protein sequence ID" value="KAG7154281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MK08"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="96" mass="11481" checksum="82F4A9AC382038ED" modified="2022-05-25" version="1" fragment="single">VSQSSDIGGVTDATSLWQSVLKVDQLLQRPNEYNTLMLLYKMQEKQRHWEMQWDMYNMMPRPDVIINNNLQMVHQNRLQVPYQARPMTANRVFLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLC3</accession>
    <name>A0A8J5MLC3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAP domain-containing ribonucleoprotein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Sarnp-L</name>
        <name evidence="5" type="ORF">Hamer_G024547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041629">
        <property type="protein sequence ID" value="KAG7155452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLC3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.30:FF:000032">
        <property type="entry name" value="Blast:SAP domain-containing ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040746">
        <property type="entry name" value="THO1_MOS11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18592">
        <property type="entry name" value="Tho1_MOS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7155452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="273" mass="29740" checksum="E08B13C9317D5A31" modified="2022-05-25" version="1">MDDATQVTKMKVADLKKELKSRGLSVTGNKNELVERLQEALEGGENVPISNVEGDDEDFDEEEILGGDDMDSTELVKLTPQEEEAALGGAIREATLLEQPEKKKISLKRSEPPLPAAPAIVEPVTENDPPAPQEEEKDEESDTPPKKVIKLDTATDKSPIEVRAERFGIPMTEEAKKLSRASRFGQATNGATINKKPAKLSMETGGTDVEKLKARAERFGEVTSKSLVKVSELEKLKTSLDSAATARIARFGDAGNKDEDALKKKRAERFGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MP84</accession>
    <name>A0A8J5MP84_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">cAMP-dependent protein kinase type I regulatory subunit-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Pka-R1-L</name>
        <name evidence="10" type="ORF">Hamer_G011444</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MP84"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007611">
        <property type="term" value="P:learning or memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000013">
        <property type="entry name" value="cAMP-dependent protein kinase type I regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0114">cAMP</keyword>
    <keyword evidence="3 7" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="74"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="192"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7158768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="318" mass="35245" checksum="59BF158C0E0507FF" modified="2022-05-25" version="1" fragment="single">QEAVRECERRVVTPDDADDLSPMPTHIATSKTRRGAISAEPLSEDDATSYVKKVVPKDYKTMAALQKAIGKNVLFAHLDENERSDIFDAMFPVNALPGEVIIQQGDEGDNFYIMDQGEVEIFVNGEHVTSIIDGGSFGELALIYGTPRQATVKAKTDTKLWGIDRDSYRRILMGSTIRKRKMYEEFLSKVSILESLDKWERLVVADALETVSIESGSTVVRQGEPGDDFYIIVEGTAVVMQARTPADEPVEVGRLGTSDYFGEIALLLDRPRAATVIADGSLKCVKLDRARFERVLGSCADILKRNIEQYNSFIALTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPL2</accession>
    <name>A0A8J5MPL2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G016523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPL2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="146" mass="16681" checksum="69EDAE7629740EA1" modified="2022-05-25" version="1">MGGTPDHVLSAGLISDRIEANLVRHLILDHIAIAVSYWVPKEATLPIRRLHYLLPDHNVETLVRYMAAWYTSNEPQSVTQVNDDLTVTIKQFYSRFESQDHLKQKARPRTQPPGSWTPVYLKLESWHTLRGTSSSVSFLTPTSSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQA9</accession>
    <name>A0A8J5MQA9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQA9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="139" mass="15272" checksum="75BF0386D70C5237" modified="2022-05-25" version="1">MVGNVIGGSLYKLGFPGQQYCVNDGLHPSTAYQGLCDKDAVSLPGPCGKGYHHPPASNSISSGGHHPMMTPHQSPHHMMMPHPAPHHPMSAHGPPHDFMDHDDHDLMRPSEFLMKGIQEPFKGLMKILNPWNILNRFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR32</accession>
    <name>A0A8J5MR32_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G021643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031456">
        <property type="protein sequence ID" value="KAG7160267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR32"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035305004" evidence="1">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="105" mass="11224" checksum="FDE09EC744594C4E" modified="2022-05-25" version="1">MKPMTVWATVGVIISITTLTHVTHARQAFKGDPGELGDPGFDLSRPTHGLNTSKDELHDHCIAESYGRDIGHCDLAYSSCPFNLGQLLTTGLSLLEGSLSGFPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MS32</accession>
    <name>A0A8J5MS32_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MS32"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="88" mass="10089" checksum="73ADC9159B0E5F42" modified="2022-05-25" version="1">MHLFLKTLYMLTVMVMTGMMMVLVLLCTPDFHTRLSNGFYRQSDLTYSQFVMQSLENPGVYVAEVSVDVEDVPYRPPPVLVLTDPRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSA1</accession>
    <name>A0A8J5MSA1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030333</name>
        <name evidence="1" type="ORF">Hamer_G030889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028873">
        <property type="protein sequence ID" value="KAG7161663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010028600">
        <property type="protein sequence ID" value="KAG7161963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSA1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="157" mass="16632" checksum="5DD3C674BDBB1586" modified="2022-05-25" version="1">MVAIQRWGRSRCWKGAKCCNQSPCAACAKRAFVTLTYCFHVGGGGIWANCGEERVDTGYGDVKLCNVLFEGRIGVVSGSDGGRASGYSATEMGAKGGASGVGYVPRGKSKEGDDQVLCIYLGGYEERKRHVDDGAGNNRGGCSIPRDSVFVGELFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSN4</accession>
    <name>A0A8J5MSN4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase LNX-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LNX1-L1</name>
        <name evidence="3" type="ORF">Hamer_G022192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027213">
        <property type="protein sequence ID" value="KAG7162725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSN4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF84">
        <property type="entry name" value="LIGAND OF NUMB PROTEIN X 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="292"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="408"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7162725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="474" mass="50493" checksum="8F6B76890AFD5B72" modified="2022-05-25" version="1" fragment="single">MVAVTLCKESSRQLGLKLGGRRTEPGIFVMEVLEGSVAAQDGRLHSHDRILAINGADVRYARLDHASRLIQQSHTHVGLVVSRGPAVAFVSGSDTAAHSPEYTSFPTHHWRNNSAAESEFQGSTDHRSASDSGCGAMEYGRSASCDSLSDHSLVSSMMSSPSTRLPSETGGGVGSPSRGGSPATSSPGYCTSDTDDTESSHHHHHHQPPAHHHRHSTSIDTHHYNHQLPVDATHDQGLHEQHPPPIDHNLLHNSTSLPATPRGARSPDDSHDIVAGLKRLIHSENNQLHQKNVTIKKSVRESLGMRIGGGVTSNEGDTPIYIANINPQGPVGRCRNIKKGDVLLSVNGQSLLGLTHGQAVALLKATAELAGVTLSLLDGPETSVGSANFVPSWLYWQKLPRSLHISKSVVLHRAPGASLGFSIVGGSDPQRGAEPIHVLFVVQSSPAALEGKLRCGDRLLSVDGHSLELVRHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSR8</accession>
    <name>A0A8J5MSR8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SCO1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Sco1-L</name>
        <name evidence="12" type="ORF">Hamer_G023251</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2) by facilitating the incorporation of copper into the Cu(A) site of MT-CO2/COX2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028090">
        <property type="protein sequence ID" value="KAG7162051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSR8"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 8 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="103"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="141"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7162051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="282" mass="31873" checksum="ABEE2DFF5C463C4B" modified="2022-05-25" version="1">MVMSVQLLSCITKQFGYLQRKEVLQFFQKYPKSSRIMVNHRLLSTVPPKSQPPRKEAGSKGKGPITWKSLLATGIIGASVLGFMQYVRKEKELALARERKRVLGKASIGGNFDLIDHNGNPKKSEDFLGQWVLLYFGFTHCPDVCPDELEKMAAVVDAIDGMENAPNIQPLFITVDPHRDSKEAIREYLKEFHPKMLGLTGSDEKISEACRAYRVYFSAGPRDDDDDYIVDHTIIIYLVNPDGDFVDYYGQNKTAEQVTASIAVNMKKYDDMNKKGILSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSS9</accession>
    <name>A0A8J5MSS9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nicotinamide phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Nampt-L2</name>
        <name evidence="11" type="ORF">Hamer_G008057</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16149"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.12"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:16151"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSS9"/>
    <dbReference type="UniPathway" id="UPA00253"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047280">
        <property type="term" value="F:nicotinamide phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041529">
        <property type="entry name" value="DUF5598"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016471">
        <property type="entry name" value="Nicotinamide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006629">
        <property type="entry name" value="PRK09198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43816">
        <property type="entry name" value="NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43816:SF1">
        <property type="entry name" value="NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18127">
        <property type="entry name" value="NAMPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005943">
        <property type="entry name" value="NMPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinamide phosphoribosyltransferase N-terminal" evidence="10">
        <location>
            <begin position="49"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="213"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7162503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="518" mass="58265" checksum="1DB4415567EE077C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTX6</accession>
    <name>A0A8J5MTX6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026096">
        <property type="protein sequence ID" value="KAG7163883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTX6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="193" mass="21853" checksum="0A2EE526B33AF1B1" modified="2022-05-25" version="1">MPRRQYRRVSDEDRDGLITRYEAGEDFLDTAAELRIPRTTAYEIIRKFVETGERRELHGGGGGRRPPVLDDEAKDFLLMLVEATPTITIRELNHTLRKTFPGKPHVCSMTVSRALDGELITLKQVNNVPANHNSEDVKAARVALAQYMYEDGIHQHRVYVDKTGYNLYSICVGPTAGLHGTTRQQDRCGTAWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUI2</accession>
    <name>A0A8J5MUI2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acylneuraminate-9-phosphatase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Nanp-L</name>
        <name evidence="3" type="ORF">Hamer_G017307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUI2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050124">
        <property type="term" value="F:N-acylneuraminate-9-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046380">
        <property type="term" value="P:N-acetylneuraminate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051400">
        <property type="entry name" value="HAD-like_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46470">
        <property type="entry name" value="N-ACYLNEURAMINATE-9-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46470:SF3">
        <property type="entry name" value="N-ACYLNEURAMINATE-9-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7164900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="65" mass="7349" checksum="DDC2A6B89BC532C5" modified="2022-05-25" version="1" fragment="single">MLDELAPDFNLGLITNGPSVAQWEKINHTDCQKYFDSIIVSGDLDVEKPSKDIYDMAFRELQVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUK0</accession>
    <name>A0A8J5MUK0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G002713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUK0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="161" mass="17950" checksum="EE1429164772FBBD" modified="2022-05-25" version="1" fragment="single">IIRLDEPKKGENQVDASVVALDLVGMLLGLNLQRRLPKTNSIRVLVAIHPSGETHFFQLIVKKAEIFKVLLQLGPSSALLQKYGGRENMMMWWMKKVVVLVIMMADVVASQSPQHKAFMSQEESVVRGSPWGVGVFEVVVDGQDANETLVLLSHLLHQARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVH3</accession>
    <name>A0A8J5MVH3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVH3"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="224" mass="25118" checksum="5429B6ACECFC8A3A" modified="2022-05-25" version="1">MTRLRWIQCGEEWEPFLLGSNKSARVVAAAEHGAGFIPGMLLFGEKRCVIPWGCKAHTKVNYYVLDKSNDVDLEWVPDVNGNVPRGAFGGGVSEEGEILYIGRFMVEGVMAYGKVHPSHKVCYVPHGSNELNNKSYEVLCFKTIPSDLVYIKTHQMPSGLSPRNFMESVGSFANGDENPLMKIKARVKGDVKITQKQNKRIQKRKSVGAAAWVRHGKSRRLQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MX59</accession>
    <name>A0A8J5MX59_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MX59"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="704" mass="77220" checksum="17B537CA859918B9" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXV9</accession>
    <name>A0A8J5MXV9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G002515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXV9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="418" mass="45443" checksum="CECDAFCD174A4F5A" modified="2022-05-25" version="1">MGASKVKLFNAVRSLLFGDSVDVGLREDHGEASQVNVAESRSVNDELRLLEWQIKLKEAEAIAKRVGIRQAEAEAKAKEVGILQAEADSENLRHKAEFCWTRLQPNTDKPAMIVTEEANTSPVGVMAGLSKADSMPIALVSTKGETRESAVSVLASRDFDLFQESFGKDPDVGTFRPFLSQGTVEVDGVKTPVTILNDSGCLQTLIKEGVVAARKTDKYVVLGSLWGQGVAPLVLVRVKSSCFSGIANVTCVHELPVAGVDLILGNDLAGGQMGNVTPPPVLRERPESTAELQQLEDDMPGAFPLCAVTRSMSMTNDHNVTPDVDGSLSLEGHFANPINVVTRRVALIAAQEQDDSLRLLFHQVSDSANDSGPTTRYFSQDSVLCRRWLPLIIKQSLEYVHDIIEWFQNTVGSPDDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXY6</accession>
    <name>A0A8J5MXY6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G020574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021277">
        <property type="protein sequence ID" value="KAG7167691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXY6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="59" mass="6546" checksum="47426FF3B4EAADA3" modified="2022-05-25" version="1">MVSTQRNNHQVYADERYDDGGHLTHSAASLHSLNPYLGGEDLVRVDVNDLEGRGDEHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYM0</accession>
    <name>A0A8J5MYM0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isocitrate dehydrogenase [NAD] subunit beta-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">IDH3B-L</name>
        <name evidence="4" type="ORF">Hamer_G021716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017414">
        <property type="protein sequence ID" value="KAG7169310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYM0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7169310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="247" mass="27091" checksum="0B0B6FC8CDBF5816" modified="2022-05-25" version="1">MKLRDELDLFANVVHVKSLSGLNVRHKNVDMVVIREQTEGEYSALEHESVTGVVECLKITTREKCRRIAKFAFDYATKHGRKKVTAVHKANIMKLGDGLFLKQCEEVAAMYPTVEFNNMIIDNCTMQMVSNPHQFDVLVLPNLYGNIVDNLAVGLVGGAGVVAGASYSTRCVVFEPGARHTFSEAAGKNVANPTAMLLASANMLHHLNLQHYGDMIQNAVDRVRTKDMGGFATTTAFANAVIASLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYS1</accession>
    <name>A0A8J5MYS1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYS1"/>
    <dbReference type="OrthoDB" id="6514241at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028019">
        <property type="entry name" value="DUF4508"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16260:SF3">
        <property type="entry name" value="CHROMOSOME 14 OPEN READING FRAME 119-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16260">
        <property type="entry name" value="SIMILAR TO 1700123O20RIK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14969">
        <property type="entry name" value="DUF4508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="240" mass="26467" checksum="7594353716CAC990" modified="2022-05-25" version="1">MPQQHTAVDQVNFLGQWFVTWSEMQREDFLPILVQAYYPKDHINGLLGGIDSLHIQGRRPSLFDCQVKLFHDWFSTWTENDRSHLLQHLREVDVEFMSQFDKKISGELSQEDIPSQAECGEEGQNPPSSVSSPPSTLPRSHSPHDSGLDEPPSDSDHTEPHSLDLYHDAEGMASSSSLPMNDAPSSLSSATKYIANPANQGDESLKLECVLNGSSEPMMTAPAAEESASSSTAKETLGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYV4</accession>
    <name>A0A8J5MYV4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein Rhes-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RASD2-L1</name>
        <name evidence="10" type="ORF">Hamer_G011657</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYV4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000475">
        <property type="entry name" value="GTP-binding protein Rhes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF3">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7168968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="161" mass="18551" checksum="D5BDF05B21453D02" modified="2022-05-25" version="1" fragment="single">FLNNKFDDTYTPTIEDFHRKLYRIRGDVYQLDILDTSGNHPFPAMRRLSFLTGDLFVLVFSWDSRDSWNEVLRLREQILETKQSASANTTGSRKKRAAARVPMVIAGNKCDREQRGVALEEVQKFVSSLSCCAYVETSAKKDNNVDKLFYELFVLANLPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYV8</accession>
    <name>A0A8J5MYV8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hu-li tai shao-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hts-L1</name>
        <name evidence="4" type="ORF">Hamer_G011673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYV8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005451">
        <property type="entry name" value="PRK07044.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF3">
        <property type="entry name" value="PROTEIN HU-LI TAI SHAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="3">
        <location>
            <begin position="131"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="629"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7168983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="859" mass="95532" checksum="FE2AF4FBE1B50760" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZ04</accession>
    <name>A0A8J5MZ04_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat-binding homolog 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Lin-48 expression abnormal protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ATAD2B-L</name>
        <name evidence="11" type="ORF">Hamer_G002633</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Thought to form a complex that enhances transcription from repetitive DNA sequences by modulating chromatin structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05528">
        <property type="entry name" value="Bromo_AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000016">
        <property type="entry name" value="ATPase family AAA domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000734">
        <property type="entry name" value="ATPase family, AAA domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="994"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="130"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="364"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1188"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1295"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1188"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1244"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1307"/>
            <end position="1317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7168547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1417" mass="161675" checksum="C74B5F8529B7662C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZE8</accession>
    <name>A0A8J5MZE8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018155">
        <property type="protein sequence ID" value="KAG7169159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZE8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="66" mass="7421" checksum="4ADE3448BF8F97C9" modified="2022-05-25" version="1" fragment="single">MAAVDEYSTTSHVLQLCLALQDRLEKVEKEVQSLKGENLALKLVLEEKKTFASVVKDGEVEVDSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZH6</accession>
    <name>A0A8J5MZH6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G018862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018499">
        <property type="protein sequence ID" value="KAG7169086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZH6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="193" mass="22231" checksum="655A2D2B1976D950" modified="2022-05-25" version="1">MQQIQNPNDPAYHKDSSRKAKNYLMLLDIIKYIHLLLDILRCLGRLSEQFQHRQTNVSTIMTEIQASVYSLNKYLTSPGPSLRKILEGDTIIFQGEKPSDRNSAFMAARDDMLTSLITCLKKRFIDMASTVLQNSWILDFKLQPAEYTGNEGFRGTNVVALFYSLEKTLREAEVDPTKLEDEWAVLKCYLQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1B7</accession>
    <name>A0A8J5N1B7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tigger transposable element-derived protein 7-like 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TIGD7-L32</name>
        <name evidence="6" type="ORF">Hamer_G025127</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013425">
        <property type="protein sequence ID" value="KAG7170826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1B7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF17">
        <property type="entry name" value="TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="78"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7170826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="224" mass="25501" checksum="C925D74B71222F1F" modified="2022-05-25" version="1">MSSRVSNTPKRKYVTLSVNQKLELIRKLEAGASVARVCDEYGVKEQTVSDIRKAKDKLTAFSLKYNVDANSKSSSVGARKRMRVAKDTNLEEAVTKWFMQQRSCGNVVRGVEIQAAAAKLASHMGIENFEASDGWLWRFRNRYGMYNKITHAWKKLLYNVERAGENDVTEDDIRNWLEDTEGDPGYQVLTEKEIADEVLFGDSRDSEDEEDDEPLPKKPKLSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N226</accession>
    <name>A0A8J5N226_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transcription factor Sp3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SP3-L</name>
        <name evidence="14" type="ORF">Hamer_G000740</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N226"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000026">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="64"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7171820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="128" mass="14884" checksum="0AA6F976C1870BA5" modified="2022-05-25" version="1">MYGKTSHLRAHLRWHSGERPFRCSWLFCNKRFTRSDELQRHKRTHTGEKRFHCPECQKRFMRSDHLSKHVKTHTKQKGMNISNPTQSSESSNSSDAGEKMLITMPDQSVDPLHISTDGDVPTNVPQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2L7</accession>
    <name>A0A8J5N2L7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2L7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035149396" evidence="1">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="97" mass="10383" checksum="49E147B127C38042" modified="2022-05-25" version="1">MHKMVIVWLSVLLLVVVAMADPGYGGYGQYEDYGQGHDDYGRGGYGGRGHSSYGQGGHGGRGDYDYGGYGDSYHGGQGYAHGGYGEGYRGYGDYGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2M4</accession>
    <name>A0A8J5N2M4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Transposable element Tc1 transposase-like 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tc1a-L19</name>
        <name evidence="2" type="ORF">Hamer_G000969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2M4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="76"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="234" mass="26691" checksum="51127A7FED8BACCC" modified="2022-05-25" version="1">MNTTQQHLTTRGQILALREEGLTVREEVDQEICRNRLRVYATALIPGYDTGDPKTILCLFSERRSRPRLNTRDEDTAIIAAIQNNPFSNPVVIREALHLDVCAQTFRSRLHEAGIQHRVPAIKERLTDQHRTGRLQFAQQYVGEDPEFWSRVVFTDEKTFASSNHGKIHLWRPNCTRYDKAHIYEVARSGHVTLNVRGYISLHGALTMTLIALFWATSNFSHCPSDSVLRAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4E0</accession>
    <name>A0A8J5N4E0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tigger transposable element-derived protein 7-like 69</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TIGD7-L69</name>
        <name evidence="1" type="ORF">Hamer_G006963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4E0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="99" mass="11270" checksum="1D2F82537A72440E" modified="2022-05-25" version="1" fragment="single">DKELEEAWYKWFVQQRDCGVKVRGVEIAEALISRLSIWVFHSKLVMDSCGGSGIAMAYVTGSCVQAQEVEPFRQKLNQLIKDEGLNLAQIYNADETRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4R7</accession>
    <name>A0A8J5N4R7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">sn-1-specific diacylglycerol lipase ABHD11</fullName>
            <ecNumber evidence="3">3.1.1.116</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha/beta hydrolase domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">abhd11-L</name>
        <name evidence="15" type="ORF">Hamer_G008635</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48596"/>
            <dbReference type="ChEBI" id="CHEBI:11152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:90605"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77107"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:77129"/>
            <dbReference type="ChEBI" id="CHEBI:186738"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:75468"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38503"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:64683"/>
            <dbReference type="ChEBI" id="CHEBI:77272"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4R7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035206359" description="sn-1-specific diacylglycerol lipase ABHD11" evidence="13">
        <location>
            <begin position="20"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="14">
        <location>
            <begin position="156"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7173109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="409" mass="45909" checksum="CA17030AD17062F1" modified="2022-05-25" version="1">MNLLPSLLLLCAVTSSSWANAPQHLTQRSQPPQLYQFRGQQKPHSPAYEQRQHSVLRPRIFDEVSSAGIFGIGIYLGELVAGTLLALLVLYLAGVVYGLFTGKKNLAFSLKGRSVEDIQYAFNVAQQVYQAIEDVPISMAYSSFQTTLPDKISNKPPVVIMHGLMGNKLNWKSIGKALNEKTGRLIYAVDARNHGDSPHAATHNYPLLAEDILYFLKEHNIPKAVLIGHSMGGRAVMAAALLEPSVVDKLMVMDMSPIRVSDSINYVPRFMDIMRRIEVPAHLTIQEARTYVDELLKPAIVETAVRQFLLTNLVQVDGGYKWRINVNTLAVHFHPYITTFPILDKYRSFEGDTAFIAGELSDYIRKDDEDKIMELFPQATFHYIEGAGHWLHVDKPKEVIELIVSLLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5G7</accession>
    <name>A0A8J5N5G7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase subunit gamma-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Polg-L</name>
        <name evidence="14" type="ORF">Hamer_G030255</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
            <location evidence="2">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008861">
        <property type="protein sequence ID" value="KAG7173811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5G7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000024">
        <property type="entry name" value="DNA polymerase gamma, catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="13">
        <location>
            <begin position="306"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7173811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="671" mass="76256" checksum="25653E60B55ED00A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5T3</accession>
    <name>A0A8J5N5T3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G032218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009108">
        <property type="protein sequence ID" value="KAG7173644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5T3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="94" mass="10406" checksum="2CD2784FB02647A5" modified="2022-05-25" version="1">MVTRTMVPHHGNKDNGAAFMVTGQWCRFMVAGQWVPLHGNKDNVPLHGNKLQWCRFMVTRTMVPLHGDKDNGAFMVMTGTMVPLHGDKDNGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N638</accession>
    <name>A0A8J5N638_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kielin/chordin-like protein-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Kcp-L3</name>
        <name evidence="1" type="ORF">Hamer_G021602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008938">
        <property type="protein sequence ID" value="KAG7173794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N638"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="202" mass="22706" checksum="52C6C8266CFD1DF4" modified="2022-05-25" version="1">MASVPGVFVWGRWACLVQVGRGRAGLASVLYREDESCAVCNDSLHSTEWDILQLLSINVSQTGVSAARGPIPDTPAWRLRALYDNIQIDSSIVPKIASTLHDQLSLYFVYKQHKKTLGSLLSINLPGKIKPFLQIVSNLKTQHLNFFYHIKEDTKTHQASFQLPDKGSIQMAKLMNYSEDDRVWKCSYDSQFGPGWRPPLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6A1</accession>
    <name>A0A8J5N6A1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 10">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Tpi1a-L2</name>
        <name evidence="11" type="ORF">Hamer_G020017</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 10"/>
    <dbReference type="EMBL" id="JAHLQT010008712">
        <property type="protein sequence ID" value="KAG7173869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6A1"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7173869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="347" mass="38813" checksum="E56BE0758B6B83EA" modified="2022-05-25" version="1" fragment="single">DITHFISDPDCINEGSVWRTHSRPRSWPLRHTVALVPGLLGTQSSSFLASWAHSRPRYSILKVITMSGSRKFFVIGNWKMNVNKTHIDNIVKFLTAASLNFNTEAVVGCPSCYLSYARHHLPSEIGVAAQNCYKVPSGNFSGEISPAMIQDCGCEWVILGHPERRAIFNEPDELISEKVVACVCERKEDRDSNRTEEVLFRQMESLAASISDWSRVVVAFEALWASGTGILATPAQVQEVLAKLRYWLRHNVSQEVANSTRIIYAGSVSSATCLELAKLKDLDGFLVSSAALNPDFVDIINSSRMSSSWLWEKHQHLQHTTALISNLRLRHVNKISNLDSYSPSRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6W5</accession>
    <name>A0A8J5N6W5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6W5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF1">
        <property type="entry name" value="TESMIN_TSO1-LIKE CXC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="468" mass="52076" checksum="E6432D13470F4596" modified="2022-05-25" version="1">MKLLRAAASSHLRPVPVCLGKSDSMEVTWELGGRLASGDVRWCPHRDGSPEDTGRPVARREWKVFSITIDQAHEQNSALIQEVGVEVGLIDDPNDLCQWMVAGPDVVRTAEEFQDGHLHMGRCSDTRHHNQRASVQTAFAKDVRSLVNMIKELGNPFEEKCLDLIFFNTKKMADPAAVEAVRKDQHLLAKLSARDLKAQEAKYHLQCLLSLYNKARQVMVQASDEMEENSLINQCIALAELVFYIEDAHTNTEAVKVFKLPGLTRMYTTRLEQLGTSISGSVHSTDLKNRILTYFPDLQAHKEGRDVFLVFNEDVGPALRKACDHDADNDDVHLTRAASIVRSDMYKLETSFTGTFNSQCQGSSVPNSLMALVSMILYGSNVKTQSSYNWAQMLVAVPSLPSPSEWGWTRNEDGGWEVKWTGLPDASHACQELLRCGCKKGCRGQCKCVKAVLQCTALCLCGGLCDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7F2</accession>
    <name>A0A8J5N7F2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Anaphase-promoting complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">APC10-L</name>
        <name evidence="10" type="ORF">Hamer_G016406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the APC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7F2"/>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000019">
        <property type="entry name" value="Anaphase-promoting complex subunit 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028841">
        <property type="entry name" value="APC10_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="9">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR028841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7174508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="191" mass="21843" checksum="9AEF2FAA07C9201B" modified="2022-05-25" version="1">MISLNNSVRVSGEEPDPAREERSGRVREVGSQAVWSLSSCKPGFGVEQLRDDCLDTYWQSDGPQPHLVNIQFRRKTTIQDVWIYADYKADESYTPSRISIRCGTHFNDLQEIEVVDLHEPTGWLLIPLKDIHERPIRTYMVQIAVLSNHQNGRDTHMRQIKIHSPVEDKAVAVESVGAFTSSAFKRYSCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8J7</accession>
    <name>A0A8J5N8J7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G009895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8J7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="129" mass="14672" checksum="DBFB76C47ABA121C" modified="2022-05-25" version="1">MFRPSRRRRDEVRLLRIRGSDAVLPVRRPTGLVRYRARTLQTVVGSLYVAAGLLCGRKPWSLRCGEKPHNYPGSRLALSHPVKAWDIGKLLPHGLRGIGNSYQFRMLSTDHLLVAAVEQQIQPKPPRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8R5</accession>
    <name>A0A8J5N8R5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucose dehydrogenase [FAD quinone]-like 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Gld-L11</name>
        <name evidence="8" type="ORF">Hamer_G021257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006462">
        <property type="protein sequence ID" value="KAG7174879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8R5"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035213444" evidence="5">
        <location>
            <begin position="27"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7174879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="608" mass="66717" checksum="84D9BD00DBAB7D25" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9P9</accession>
    <name>A0A8J5N9P9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004929">
        <property type="protein sequence ID" value="KAG7175661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9P9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="262" mass="29019" checksum="13D5301BB0073DC7" modified="2022-05-25" version="1">MESTRSKTEVWLISQHITEITGAQLPSRGDVLRLFFHGHNEHKKTVNDSASEVAASVISFWNIARIPTITEKSIGRKVVDLFLMWKGLKKNCTRTTDTQRKKEETFCDELEDLFDVAHPKAIQLLTIKEDRAFLAAQREKGRRGVMAGVDKKIACSIKRREESKSKQSLQQNQASSALEYDELGSSSETESQSSSSSSTSSLAISPVVSSSNRKHATLKVITPELSSTLDRTGISHRSALRIGQAQRLARVGTGREAGHWPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9X1</accession>
    <name>A0A8J5N9X1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Golgi to ER traffic protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GET4-L</name>
        <name evidence="6" type="ORF">Hamer_G009739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GET4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9X1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000060">
        <property type="entry name" value="Golgi to ER traffic protein 4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7175737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="287" mass="32236" checksum="1370D07A1B48A140" modified="2022-05-25" version="1" fragment="single">YCSQQKYKEVLDLLFDGASLLLIHDQQTSGADLALLMLDVLEKSKTEPTDDQISRIANLFSLLNHGTPERHQYLVRAVKWSCGETHKLGHPRLHQLLAQTLWKEKNYGSARYHYLRSEDGGGCANMLVELHLLRGYPSEVDLFLTQAVLQYLCLQKKVAASEVFETYTKKHPNITKQRGPPFLLPLLNFLWLLLSTIESGKVTYFTVLCEQYQPSLKRDPSYREYLDRIGQLFFNLPAPRPQHGPGGIFGNLLQGLLGGGLGDDDSEDEGTMGGPSSSQPMAAEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAP0</accession>
    <name>A0A8J5NAP0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione S-transferase 1-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GstD1-L5</name>
        <name evidence="6" type="ORF">Hamer_G016945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7175989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAP0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03045">
        <property type="entry name" value="GST_N_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000034">
        <property type="entry name" value="glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000007">
        <property type="entry name" value="Glutathione S-transferase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01153">
        <property type="entry name" value="Main.4:_Theta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035270171" evidence="3">
        <location>
            <begin position="22"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="110"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7175989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="240" mass="26876" checksum="3142610A4FFB3473" modified="2022-05-25" version="1">MVVLGAMVELMHLVLLLSIRAKMTLDFYYMAPSAPCRSVMLTAKAVGVELNLKELDLMAGEQMKPEFIAINPQHCVPTLVDDDFALWESRPICSYLVNQYGEDDSLYPSDPKTRAQVDRLLYFDMGTLYHRFGEYVYPVVFRGQEEPNPQKLESLQEALGWLNDFLDGHEWAVGDTTTIADHVLVASVSTLEAAGIDITGHANIVEWLERCKSTMPGYEEVNEPGAVSFGEMVKAKFSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAT7</accession>
    <name>A0A8J5NAT7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003784">
        <property type="protein sequence ID" value="KAG7176197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAT7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="147" mass="17212" checksum="EE6128276FBB9685" modified="2022-05-25" version="1">MTFLNKEYRPYVGSESFQFFAQDNLRFSDNINERVLRDELGETYIKFCTERNLPIASMVNIGAHLAQSGVCVKRLGTRFGQQYGYCHLQWIDPTGFTKYFPIYKKRKADKEVCPTLPKYKPPIEKPPPVNREPVKVIVLQCVKLRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBB4</accession>
    <name>A0A8J5NBB4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Muscarinic acetylcholine receptor DM1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">mAChR-A-L1</name>
        <name evidence="14" type="ORF">Hamer_G009126</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBB4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000288">
        <property type="entry name" value="Muscarinic acetylcholine receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000995">
        <property type="entry name" value="Musac_Ach_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF265">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR DM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00243">
        <property type="entry name" value="MUSCARINICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="330"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="224"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7176333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="438" mass="47854" checksum="8D904EECF8E1ECB8" modified="2022-05-25" version="1">MRHEAEEVVEPEDWRRQRSESSTAMDEIETTYVPTAMVIENTKYASQGRTGSGGCCRGLASCIKRTVDREEAGSQAGGHRSGYNTPGYHTPGYHTPGYNTPGSVETTLPSSVSRCTSLNYIREPLTVTPTRYHQNSMIPLVERAERPDHHHHHHHHGTSATLPRAESTLGVGAAGRNQMVGGRLQARSHSSDSVYTILIRLPHDPSQDGPLNPPSILMIEEEGQDGSGANAGHRLRFDRGTSPLARRGDSVCSDPSGQSTRVECSLHPGGPEGTSPTPNRRTSHAPDIKIPLNAKIIPKQLAKNSGTGSGNSGGGVAGAGTNSGTAVPGKKKKKKKSQEKKQDRKAAKTLSAILLTFIVTWTPYNVLVLLKTVLACNPDDCIPRQLWDFSYYLCYINSTINPMCYALCNAAFRRTYVRILTCKWHSRRKQGVQRGYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCJ1</accession>
    <name>A0A8J5NCJ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kruppel-like factor 18-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Klf18-L2</name>
        <name evidence="1" type="ORF">Hamer_G027313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001989">
        <property type="protein sequence ID" value="KAG7177505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCJ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="287" mass="33140" checksum="CF347A29C12FC487" modified="2022-05-25" version="1">MSQRSGPSTKEHSVTKEIHYWRGRGQGNDHLLSIADIKTQLGSPTLSDPVSYTTSTTIHPLHHVHYNTSTTPHPLQYIQYTTSTTIHPLHHIQYTTPTTPHPLHHIHYNTSTTTHPLHHIHYTTSTTPHPLHYTHPLHHIHYNTSTTPHPLHHIHYNTSIAPNPLQHIHYTTSTAPHPLQHIHYNTSTTRHPLQHIHYNTSTTRHPLHHIHYTTSTTTHPLHHIHYNTSIAPHPLQHIHYNTSTTRHPLHHIHYNTSATPHPLHHIHYTIIYIISTPLCSPIIRCTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDG9</accession>
    <name>A0A8J5NDG9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Transposable element Tcb1 transposase-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Tcb1-L9</name>
        <name evidence="4" type="ORF">Hamer_G008413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDG9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13551">
        <property type="entry name" value="HTH_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="3">
        <location>
            <begin position="121"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Transposase Tc1-like" evidence="3">
        <location>
            <begin position="791"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="860"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7177742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="959" mass="108172" checksum="E7D0C8F8036DAC01" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDH0</accession>
    <name>A0A8J5NDH0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDH0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="87" mass="10081" checksum="8210D2FDE6D3ADC7" modified="2022-05-25" version="1">MEGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIRDNDDALYIIEGDTWEFTAIWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T6Q3</accession>
    <name>A0A8J5T6Q3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LARS2-L</name>
        <name evidence="12" type="ORF">Hamer_G018700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010009960">
        <property type="protein sequence ID" value="KAG7173414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T6Q3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000002">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000003">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="229"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="591"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1019"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7173414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1051" mass="120937" checksum="4B88C0801AD26580" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T7R7</accession>
    <name>A0A8J5T7R7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G018921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009009">
        <property type="protein sequence ID" value="KAG7173774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T7R7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="79" mass="8946" checksum="481A1E1D46CBFDFD" modified="2022-05-25" version="1" fragment="single">MIKSSPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSRERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TC43</accession>
    <name>A0A8J5TC43_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008770">
        <property type="protein sequence ID" value="KAG7173835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TC43"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="263" mass="30416" checksum="E333D9EF82039E93" modified="2022-05-25" version="1">MQEQRTQRRCIETKGFLEFVNQKLQITGCKTDVILRDDLYHKYKMYCKCRGLMPATIVNVGRTLAKKGVKSPSRIGGINGKGQKYGYKGIVFQPCMEVVPWHPYSAVYSMHSDSVISGKRKLEEQDQNEPKRAKITGEIIDPISTFLESFVSTSLDHNELVRQNDLFNEYREYCRQNGLERYNNIKLGRLMTARGFKPTVRVGKPNSQQYCYPGLKWTREAPSGNKYTNLKQQRCHPVCPDRVISETKRYLLICLAIQFVNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TI05</accession>
    <name>A0A8J5TI05_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007025">
        <property type="protein sequence ID" value="KAG7174750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TI05"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="282" mass="32381" checksum="EC2834976CFB7323" modified="2022-05-25" version="1" fragment="single">MNKELINDMIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKRNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERREAYLLIHLSTVEVDTASRSAMART</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TID6</accession>
    <name>A0A8J5TID6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-L-iduronidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Idua-L</name>
        <name evidence="7" type="ORF">Hamer_G001363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TID6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003940">
        <property type="term" value="F:L-iduronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049167">
        <property type="entry name" value="GH39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049166">
        <property type="entry name" value="GH39_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051923">
        <property type="entry name" value="Glycosyl_Hydrolase_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12631">
        <property type="entry name" value="ALPHA-L-IDURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12631:SF8">
        <property type="entry name" value="ALPHA-L-IDURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21200">
        <property type="entry name" value="Glyco_hydro_39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00745">
        <property type="entry name" value="GLHYDRLASE39"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 39 N-terminal catalytic" evidence="5">
        <location>
            <begin position="138"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-iduronidase C-terminal" evidence="6">
        <location>
            <begin position="612"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7175306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="683" mass="78755" checksum="09BF523D426C8C1D" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJH0</accession>
    <name>A0A8J5TJH0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G030184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004058">
        <property type="protein sequence ID" value="KAG7176146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJH0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="501" mass="60203" checksum="CC74AA4C111295C4" modified="2022-05-25" version="1">MTCIITLSLTTCNITHLSDVYYNTPLNDVYYNTHLNDVYYNTHLSDVYYNTHLNDVYYNTLTTCNITHLSDVYYSTHLTDVYYNTPLNDVYYNTPLNDVYFNTLLNDVYYNTHLNDVYYNTHLNDVYYNTHLNDVYYNTHLNDVYFNTLLNDVYYNTHLNDVYYNTHLNDVYYNTHLVTYYNDSALTTYYNTHLNDVYYNTHLNDVYYNTHLSDVYYNTHLSDVYYNTHLSDVYYNTRLNDVYYNTHLSDVYYNTRLNDVYYNTHLNDVYYNTYLSDVYYNTRLNDVYYNTHLSDVYYNTHLNDVYYNTHLNDVYYNTYLNDVYYNTHLSDVYYNTYLSDVYYNTHLSDVYYNTYLSDVYYNTHLSDVYYNTHLSDVYYNTHLNDVYYNTYLSDVYYNTHLSDVYYNTHLSDVYYNTHLNDVYYNTLTTCFITTTTRVRPRHTTSGTANDRTANVVNRCLIPCRVAYKIPGSIGNKASVTHYPIPPRAGTVFPKVPLLTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJW1</accession>
    <name>A0A8J5TJW1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative obstructor B2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G009210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJW1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="180" mass="19620" checksum="F590822F8FFDF690" modified="2022-05-25" version="1">MDIMPHSRHNNPSNYYVEYFDNYFKTLETTNGHVSADILAAAITSGYDVPQLKKRIDLSSGTGARRPSKARGSTPAPPRAPAAPTRPPVSQPRPPVSPTRHRFGTQSKPTATAPPPPPTPIEEAAYDYPADYTDPAYYDYPAEAAEPAAPPSTTTPAPAQAPRLPVIRRRVPLRNLRPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TL72</accession>
    <name>A0A8J5TL72_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitotic-spindle organizing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mzt2-L</name>
        <name evidence="6" type="ORF">Hamer_G003349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TL72"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024332">
        <property type="entry name" value="MOZART2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12926">
        <property type="entry name" value="MOZART2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7174407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="86" mass="9693" checksum="A1B0159BEEF211CB" modified="2022-05-25" version="1">MSEVHLYTLVTKNNLNSEQRQLFDLVRAAGIIIHPQLFKTVMDLLAQNIPPHALINLLRDLSSKIPCGEDVINQNTVQEGNMNDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J812</accession>
    <name>A0A8J5J812_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Arpc5c-L</name>
        <name evidence="7" type="ORF">Hamer_G023180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045868">
        <property type="protein sequence ID" value="KAG7153961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J812"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000003">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7153961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="153" mass="17028" checksum="D7A67D0ADFBC3F12" modified="2022-05-25" version="1">MAKNTLSSEFRNIDVDQYNEDNFKDDDVEPQSPPIGVDEATIISYMNSGNHADALKLLLANAPVASKGKNEQAKDMALNLVLKVLLSVNKSQMDQIITSLDKTQLDVLMKYIYRGFERPSEGSSAILLIWHEKVYNAGGVGCIVRVLTDRKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J9P6</accession>
    <name>A0A8J5J9P6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046530">
        <property type="protein sequence ID" value="KAG7153569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J9P6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="307" mass="34610" checksum="BD703FBC1CA60F6F" modified="2022-05-25" version="1">MASIKSKKTPGKNDLSVNKRKSQKMKTHAASQVKKRPSGTQEAKGKRKPVKPKHGKKTNTGNPSRRQKTNAMVTKHGKKTNTGNPNNKQKTNTMVTKHGKKTNTGNPNNKQKSNARRGKKTKAGKPKPSLKTGRNKLGKTNTRKLESGERGKSTNHRPGGISSLNRKKWNRNVDKNWKVNSVNAMPLKYTPKVKRNWDRELVGIKGTNKRRDLKDYRKIYSSASSTWNNKIYRKRFRRRKIDEGPREIVSDVTKLVNLDVVNQAIGGIRTLATKAKENKTKKNLLEDTGEQDAMIYLQDPSTGEPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JC91</accession>
    <name>A0A8J5JC91_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Tbb1-L4</name>
        <name evidence="14" type="ORF">Hamer_G018235</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044460">
        <property type="protein sequence ID" value="KAG7154484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JC91"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="29"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="228"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7154484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="426" mass="48050" checksum="3E678F24193CBEEF" modified="2022-05-25" version="1">MFWEIISDEHGIDPTGTYRGDHDLQLERINVYYNEATGGKYVPRAILVDLEPGTMDSVRSGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESEGCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLSTPTYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQMYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNIQNKNSSYFVEWIPNNVKTAVCDIPPRGIKMAATFIGNSTAIQELFRRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEYEDEEEHAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFE8</accession>
    <name>A0A8J5JFE8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G027725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JG39</accession>
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                <person name="Romanova D.Y."/>
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                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">GMGI-L3</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="118"/>
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    </feature>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="term" value="C:dendritic spine"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
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        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7155635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="208" mass="22782" checksum="422731942E28CEE2" modified="2022-05-25" version="1" fragment="single">MERTGGSSSAWEISDTICSAWVISDTICSAWVISDTSYSVWKIRDTSCGTLETHETSWRYVTPATVSRVTSCGRMVTAEAERNSGWRRPKTRTVMPRAANHKANGGGATSNGSTPSTPIGQNQQVSTNQTPSSPPDMPSTNKNKNKKEKEANKKKGRSKEVMIHEPAVLIEGVLFRARYLGSTQLVSEGQPTKTTRMMQAEEAVSRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JI78</accession>
    <name>A0A8J5JI78_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046384">
        <property type="protein sequence ID" value="KAG7153594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JI78"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="78" mass="8481" checksum="20D83F7D36AC396C" modified="2022-05-25" version="1">MEDFIVISNTGVGAVSHMFIVVYKSDLHTCAALHSLPHLLSIVHRLKNLVSVSYLTSLSYPQPGQAEMGRLNAANKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJU8</accession>
    <name>A0A8J5JJU8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Collagen alpha-2(IV) chain-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Col4a2-L3</name>
        <name evidence="3" type="ORF">Hamer_G022098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031890">
        <property type="protein sequence ID" value="KAG7159872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJU8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="381" mass="41524" checksum="B876887A7309F77A" modified="2022-05-25" version="1" fragment="single">GPLEAEVRDGGKTLPGSEDPESDVEAPNGVNESIFSSTPVSTSLLMTALGVGSGFVLLVILLLLLFFFTFRRRRRCRRTPQERSITRAGSPPEGVVVERRSSQSSSPRCSRPGDSPVLTRGHHTTCLKELPVFSQQVEVESDANPDVIPVRETCLGCRREPPPARPTPQPSPQYRSGERGTPPGRAAPQFSAQYRETPPGGATPPQVFQQCRGCERSAPHYREGTPGATTPQLSRHYREVSPGIPAPQLSHQYREGTPGPPTPQLSHKYREGTPGAATPQLSRNYREVTPGNTAPQSSHRYHQYAQGPTHLPTIRGAVAIPPHYTASNLHLFCVSSYLSTSSSPSLMVETKEGPHLSLMACLYHRSDGELFGKKAKEKIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJV5</accession>
    <name>A0A8J5JJV5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Disulfide-isomerase A5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Pdia5-L</name>
        <name evidence="5" type="ORF">Hamer_G005821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJV5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02997">
        <property type="entry name" value="PDI_a_PDIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000029">
        <property type="entry name" value="protein disulfide-isomerase A5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046374">
        <property type="entry name" value="PDI_a_PDIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF2">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035188971" evidence="3">
        <location>
            <begin position="21"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="124"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="245"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7157398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="589" mass="66411" checksum="CDDB6AD17FD588C4" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JK64</accession>
    <name>A0A8J5JK64_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pro-resilin-like 84</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G016548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JK64"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035248040" evidence="4">
        <location>
            <begin position="16"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7159165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="259" mass="28119" checksum="D8394D102DFFE409" modified="2022-05-25" version="1">MIVVLFAALVAAAFARPDPQYSSPTPAYNPPAPSYNAPAHPRPSYSAAPAYPDTPPQYNSQYAVRDDYSGNDYGHEESRDGYNTQGTYSVLLPDGRVQRVTYYVDGDSGYVAEVVLFAALVAAAFARPDPQYSSPTPAYNPPAPSYNAPAHPRPSYSAAPAYPDTPPQYNSQYAVRDDYSGNDYGHEESRDGYNTQGTYSVLLPDGRVQRVTYYVDGDSGYVAEVTYEGEAQYPAYHPAPAPSYRPAPAPSYTPAPSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLP9</accession>
    <name>A0A8J5JLP9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G008954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLP9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035258360" evidence="1">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="112" mass="12678" checksum="9B5AF3509EEE016C" modified="2022-05-25" version="1">MSRGRWWGTLVVVAWVTAAMTADISTRVIAAPPNTSESSDDGVGDGRLRQISLDCNSPSCCGYTKSSVGCRFQGRRCRCPFVIPRPVPFTPYDIYHHLRRQRPTYQDDQDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMC5</accession>
    <name>A0A8J5JMC5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Solute carrier organic anion transporter family member 5A1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Slco5A1-L2</name>
        <name evidence="2" type="ORF">Hamer_G008800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMC5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00282">
        <property type="entry name" value="KAZAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kazal-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="184" mass="20440" checksum="A6A41CA590958DAC" modified="2022-05-25" version="1">MNTLRCTLCCVTYETPCTLCCVTYETLCTLCCVTYETPCTLCCVTYETLCTLCCVTYETPCTLCCVTYETPCTLCCVTYERPCTLCCGMIPKAFVARKAKVAQEDIINGILRGRIKAASITLKLSISLGQKKNGEKRESCLRKCVDYNPVPESCITTEGQGRFKKDLGPRASPFSTQLKINKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMR6</accession>
    <name>A0A8J5JMR6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Mediator of RNA polymerase II transcription subunit 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Mediator complex subunit 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MED20-L</name>
        <name evidence="6" type="synonym">MED20</name>
        <name evidence="7" type="ORF">Hamer_G023755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035341">
        <property type="protein sequence ID" value="KAG7158395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMR6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013921">
        <property type="entry name" value="Mediator_Med20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12465:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12465">
        <property type="entry name" value="UBIQUITIN SPECIFIC PROTEASE HOMOLOG 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08612">
        <property type="entry name" value="Med20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7158395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="158" mass="17854" checksum="D4B9199FADD553AE" modified="2022-05-25" version="1">MHIVHNSETPTTTYAILDTGSKQVTLSADYLFDLMLPRLDHMYQSKKNLKIESKGAKYEIGDFLVKIGSVTMSGHYKGILVEVEYLPCVTPALCWSLVREFMQSFMGSCVKPTLPSYLQTRLHDIHTPQDTVQQYVEKFNEFRDGPSFTATQPATPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JN85</accession>
    <name>A0A8J5JN85_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sperm-specific protein PHI-2B/PHI-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Spsy-L</name>
        <name evidence="8" type="ORF">Hamer_G014037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JN85"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF36">
        <property type="entry name" value="HISTONE 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7161397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="140" mass="15482" checksum="735CD7EE05AE1B31" modified="2022-05-25" version="1">MDMIIEAIENLGERKGSSVQAIKAYILQNFKTVRTDMVKSMLRRALNLGLEQGVVSRPKGQADTQVMSGRYLLGKSAKKEDEDEVMPQQSKRAQDAKKSAKKGKKKGGKKASKKVAKRPVAKKASTPKSKRPVKKTKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ85</accession>
    <name>A0A8J5JQ85_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fatty-acid amide hydrolase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Faah2-L</name>
        <name evidence="1" type="ORF">Hamer_G010060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQ85"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052739">
        <property type="entry name" value="FAAH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF4">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="167" mass="18870" checksum="9EA6A2C0B452EDF8" modified="2022-05-25" version="1" fragment="single">MDFLVTGPMCKYAQDLTPMLKILAASNSHMLKLDEKLNAADIEEWIHIDDDIEVAATFTDQEIIESITTPEKIEENFQKNLLKKTTKFKKRYLGLLQKRALKHLQDVMHAHMVQNNLITKKLQSRKQGDIRKYLKKVVSSSAADAVEAASVPSTSSAADDIEVEINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQZ7</accession>
    <name>A0A8J5JQZ7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exportin-6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">XPO6-L</name>
        <name evidence="10" type="ORF">Hamer_G019393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027477">
        <property type="protein sequence ID" value="KAG7162672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQZ7"/>
    <dbReference type="OrthoDB" id="10261013at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040016">
        <property type="entry name" value="XPO6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21452">
        <property type="entry name" value="EXPORTIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21452:SF4">
        <property type="entry name" value="EXPORTIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7162672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1154" mass="131950" checksum="B5B67D378FF76F60" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRE0</accession>
    <name>A0A8J5JRE0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor SOX-14-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Sox14-L2</name>
        <name evidence="7" type="ORF">Hamer_G022265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027013">
        <property type="protein sequence ID" value="KAG7162810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRE0"/>
    <dbReference type="SMR" id="A0A8J5JRE0"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22028">
        <property type="entry name" value="HMG-box_SoxA_SoxB_SoxG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF324">
        <property type="entry name" value="SOX DOMAIN-CONTAINING PROTEIN DICHAETE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="134"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="134"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7162810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="462" mass="48725" checksum="7FA7586BC1CCC8BF" modified="2022-05-25" version="1">MYPTMMESMPVSYASTMGGMMGHYFGGGSAGMGVGAGIGQIPPAHHSNALAQQQPPQQPPPQQESGHPHQQASHTPHAPAQNTPETLTASHAHLRQAALVTPVSTPSPADSTASGCSPSGSAQKKENGSKDDHVKRPMNAFMVWSRMQRRKIAQENPKMHNSEISKRLGAEWKTLTEAEKRPFIDEAKRLRAQHMKDHPDYKYRPRRKPKTLKKDGYPYSIPYPTVSMDPLRGGFPSQLSPYYSASAAAANYGSITAAHMAAAAAAAAAAQQQLTTQASQVSPVGYGYDASKYTSYMTGAAGYPMSMYGSAAAAAATDQKYGDTSKVAAAAAASAAVGGYEAAKSYLDSSKYLSDKYGLEKPTSYLDKLAQDPKDAEMKSASPGISSVNPGPMAGYGSAAGALSNYYSQAASTSAFQPSGALSQGVPSTMASLLQPSQVASYTNAQYPPVGADYRRPLSVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRX5</accession>
    <name>A0A8J5JRX5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G002164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRX5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="89" mass="8803" checksum="215FD93AE286FD0B" modified="2022-05-25" version="1">MGGICGRGRVGGVDRHGYPGGVGLRGGVRSVDGRGYLKGVGGCGGVGVTDGRGDLSGRVTGCGFDLDGRLGGRGVVGGGVRHPHHQRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWA3</accession>
    <name>A0A8J5JWA3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SCAN domain-containing protein 3-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ZBED9-L8</name>
        <name evidence="2" type="ORF">Hamer_G007859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWA3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF22">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="418" mass="46775" checksum="D69E7334D9B88D67" modified="2022-05-25" version="1" fragment="single">MKEDEPNSSICFHAPSKITVRTSLTLNNLWGMFVVFSGGHLLSLLVLCEVPQCEICHKVLGNDSMKPFQLKLHQRLAQRDRAFLKNKSDGLKKLWLDDSGSTQQTSKATTHASYVIAIAKIVLNDVAVNKLKQIPLSNNNNKSRIRDIAHNIKDQDVIGVCTNGAPAIGYFPDINTIQITMALTRNPFKCHGNDVPTKLQEEFCLLKHNSSAKDEFNFVSLSEFWVKMCPIYPGLGNNALRVLMQFSVTYLCESSFPSLLPIKSTTRNKHQVECDLRTCRNAVSPKQQVVDPFQGELWVALLVSVVAWGVTLWLIHRAWRWFAGGRGVKFTTAFLYGWGALLERPPSNPSVSDSGKPVTTAGGLQKVKEGSYSFFSAKYHITVIIDSKYTNSYGQTPFYISKRGIKVLAAFGWSFRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXS7</accession>
    <name>A0A8J5JXS7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Transposase-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXS7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="131" mass="15346" checksum="382D4164BC6A39F6" modified="2022-05-25" version="1">MNTTQQRLTTRGQIVALREEGLTVRAITRPTCCFDFNCEEVDQEICRNGEALHLDSAQTVRSRLHEAGIQHRVLAIKERLTEQHLTRRLQFAQQYVGEDLEFWSRVVFTDEKTFASPNHGKTHLWRPNRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JY88</accession>
    <name>A0A8J5JY88_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G014150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JY88"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="441" mass="48337" checksum="71D8AAF10CD9920D" modified="2022-05-25" version="1">MKETIGVVSEESSQKRVKYTLEPVARLARKSITPLRLDQHLNNMILRGIQETSFNSTLPEIEALEDKTSRPANILQHPLPLHSFLAVIGVGPHTYDSATGKYKLSWRTVRGVHTLATALCITSLTATTIFGLSKYIIVIAPTIPAETARQKHPSDRRSDRGWIPGERPGPGAQYYSGAPPVSTPQQLESPGVAGQPVFLSHVLDGLAERMFLVPHSWLVPQTFTTKLVHLAVCSVALHQFAINKGYVFAFTTHCHLLSTGLVIWNTQLTNALEDVWERGSRGEVLGRLVQRRHHLVRMGDTQQLFSPVLQCILRHHGGNRVHGALPPGQGCRWGVQSGRAGDPGAAHSTDQLAARTRLPRCRHCPGTGELARSLTTSQVYITGGNFFIINRSFILTCPRGRSLAHQPYSGGVHVMPCRLPNNLTLRAPTSSPAHQPHPGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYC7</accession>
    <name>A0A8J5JYC7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G005129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYC7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="67" mass="7597" checksum="94B61FB9B579694C" modified="2022-05-25" version="1">MHGCHCVQIRKRMALLQTDKEKTLHLHRTIHIWWAKMASPVGSQSVPGVELKFLIRPTCGSTNITFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYL8</accession>
    <name>A0A8J5JYL8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYL8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="171" mass="19168" checksum="33170353690255DE" modified="2022-05-25" version="1">MRSGLIIKVANLAYRKTQEEEEEEDSYGIADSASRRTSSPHPSSFYKFLDPSVYPPRSRQQRAITQGIGEMEEAEKLLLSAATHLDTDGCVLKLLCHLNNKQVDARTLEETVLLQMFSDNLETMFSYNTAFKNATEAEQGVCDHVLTQCPLGEEELGNVMRQTWSCASLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYV2</accession>
    <name>A0A8J5JYV2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat domain-containing protein 16-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ANKRD16-L</name>
        <name evidence="4" type="ORF">Hamer_G005492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYV2"/>
    <dbReference type="OrthoDB" id="6335178at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7167147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="370" mass="40774" checksum="C00C20D90451A05B" modified="2022-05-25" version="1">MSTHSDTDVLSAVQRGDLNWLEKYTSENEVDWRTCIHRKSGDTALHIAAVAGCTQIMSWLLANGCDVCLEKQNMDGKRPLHSAAQAMHFPIVKILLDHGATVDPIKRGDWTPLMLACAKRCLKVIQLLVEHGANLRWVNKDGWTSFLIACREGFECIVNYLLDVDSSLWNTVSNNGRTPLHTAAMHGHESVVKILLHRGNYKKDEDDACGNTPLMEAFRMGHLNIARLLIIEHGTDIKVRDKTGRTAFHIAAEAGQLESVKTLIETYGVDVNLLSDAGSSAVHCAAREGQTEVVVFLIKMGCKVSIKDNNGRTALWMACASRKNTCAKKLVDFGAQDIADNKGISPSQLMPIYHLSPVTLPNTEDLFSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYV5</accession>
    <name>A0A8J5JYV5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYV5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37487" checksum="5B8CC813C755451D" modified="2022-05-25" version="1" fragment="single">MSSEEKMLGEGEESPHDTPQAITITIMDPSALETTTLDSTLVTTVQTHDTSHGTSTLLMVPEEGHASISVKHGAKDILETVTETHMGTHELPVISNISNPEEEINEQSTIQVMTKTSEIIDEVEGEGVEEGDDGEIADEPVGQHCLICNVDLPVEQSEESVLVFKSQTTTTQRKMAVFLGSLIGQKLTSRKAHSDIMCQRCFGLLDRVDALEVEIRDTKEEIVNTYQETVAAYGGRARRRKPATAKKTDYVFPKVEPEDEDDQVLGLEMDETFEPRVEDLMEEEIDHREDRHTQDEEWEPDIKKPKIKKEAVDTEPTGPPKRKRGRPRKDASKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZC1</accession>
    <name>A0A8J5JZC1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G003650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZC1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7164444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="479" mass="52082" checksum="78141F1C9AB977CD" modified="2022-05-25" version="1">MTYHGAARYEQVNIPCDLDSYPTPTAFRWTFNNSGESVDISQDHILVAGSRSTVSYTPNTELDYGTLLCWGINSVGQQRHPCIFHVFPAGHPDPVHNCSVYNLSVTVVNVRCVAGFDGGLPQTFILELYQPGVDHLLANASSLVPVFTVGGLPPGMTFRARVYSYNNKGRAETLSLHVYTIKDLAEKRTVKPSPPPEKQQKEELLVQPIVAVVVGVLGGLLLVVGVICALVRLQYGRRSRQCGRAETQDPLSGEEDTKISPTTLKDVAPPSASSGAESWVVGSVTTISSASLPTTYASLPRPSHLSTPANYQQQCGGDDMQYNELRLGGTVPAAAPHDPITHTLLPHNPNIQPLRDPSTHTQSIHPHCPNTQPKTPTHTTQHHDPHIVAHGNLDDNHCHTHYPPPHQQLSAYPHQSTVIPSPTHTVHQSAPPHSGHPQQASWTPSSASIGRRHSLRRDPHPCDTEATVPLMSNQKESSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZU5</accession>
    <name>A0A8J5JZU5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">snRNA-activating protein complex subunit 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SNAPC4-L</name>
        <name evidence="11" type="ORF">Hamer_G020818</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026066">
        <property type="protein sequence ID" value="KAG7163903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZU5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="369"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="423"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="423"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="9">
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            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
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            <begin position="474"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7163903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="662" mass="76271" checksum="305A744B5D6F6D9A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K076</accession>
    <name>A0A8J5K076_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zonadhesin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K076"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035162689" description="Zonadhesin" evidence="1">
        <location>
            <begin position="17"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="43379" checksum="3E1CAE712656751E" modified="2022-05-25" version="1">MWRLTATLLVAALASASPQAGYLPPRPDPVCPAVTSVVYDTRVQTSVNVQTVNQVNTQYITTTQVRQQVVPTTVYQTRVQTQVQYQTSVVQRTTNVVNDRVVTNTVPSPPREETRYVTSTRVVPQVSYVTRTQVQTQVVPVEVTRTQVQTVRQPVTNYQTQVQQQTRVVSVPGRDVVQTRVQTIVQTSVVSRRQPGNTRYVTSTNVQQVVQTSVVRGQDVVRTSVVQRQQVIPYTSVNTRYQTTYVTREQVVTRTNVVTQTQVQTQVVPQEVVRTQVVPTTIYTTRYETRVQPFTQVQTVVQTRYVTPAPVVKTQQQVQTSVVQVPGQNRVITKQVVQTQPRQEVVYQTVNQPQQVTVTQTITATCGKTGYNYQRPATPFNFPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K084</accession>
    <name>A0A8J5K084_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G025541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021262">
        <property type="protein sequence ID" value="KAG7167702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K084"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="193" mass="22362" checksum="FE5B9E17A89A5BC8" modified="2022-05-25" version="1" fragment="single">MGWGGGKEDRGREGERRGSFKVRLRKGEGEAEGFHLHEKVAHAAQAAISRHLWYLSEHLIGLSLFDDRIDTETKKNMVQNFQCPKKQDFSRRIVLSDETPISNVASFVTERTLDIFDVLTLDGKERAQLFLKVSGIFFIYPIVQLERAFPSLWGKQDPFPLLWSKRDLFPSLWGKQDPFPLLWGKRDLFPSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1G1</accession>
    <name>A0A8J5K1G1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 301a1-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Hamer_G030377</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023660">
        <property type="protein sequence ID" value="KAG7165783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1G1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11054">
        <property type="entry name" value="CYP24A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035209199" evidence="10">
        <location>
            <begin position="23"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7165783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="468" mass="53623" checksum="E99287ECED297981" modified="2022-05-25" version="1">MTSIRGCGKLLLTGLHPRLCLAATALQARGAAEATSAMTQVQPLPASQIPGPRRWPVLRSLPAMYRHRLFEAGHHNTIWEALCEQYGPIFRVDLPRQPPTVFITDADEVSHLLNQTAKNPVKPPTEALRLLRNSDKNKFVPEELGLLVPSNGEQWWRVRRLIQPHVMKMNVLHYHLPQMDQLAKKFVERLSGLLNEKHEAPANFLQELNKCFLEGTSLISFDKWIGCMEETTEGKELIDAFQTVLQITVHHQFNALLRIWDWFSTPTYKRLKKAHEVIQQFAEEAINKTLTTIERENISSNMEEVSLLTKLLLTPGLKRTDVYAFLVDFTIAAIDNTSNTVSNTLYCLATNPDIQLKVHQELDEVFNVSVILQPMGMNEKYFPQASQFQPERWLRDQGKNYHSYASLPFGFGTRMCIGRRIAEQEMNIFLCRLLQKYQVEWKDESLNAKGTPVSSSHEALKFTFTERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1N8</accession>
    <name>A0A8J5K1N8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tryptophan 5-hydroxylase 1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Tph1-L1</name>
        <name evidence="9" type="ORF">Hamer_G024581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023602">
        <property type="protein sequence ID" value="KAG7165794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1N8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004510">
        <property type="term" value="F:tryptophan 5-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF16">
        <property type="entry name" value="TRYPTOPHAN 5-HYDROXYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7165794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="158" mass="17728" checksum="03FAC4D1D8189FF8" modified="2022-05-25" version="1">MNLYFFTVEFGMCKEDGNLKVYGAGLLSSIGELRHSLSPAAKVEPFDPDPVSTVPCLVTTFQNQYFYTDTFEEAKEKLRAYVSKIQRPFGVRYNPYTMSVEILSNAEKIAALVSELRGDLCIVRNALQKIHENDDDVDIENITSILTSALKTEDSTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2C3</accession>
    <name>A0A8J5K2C3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="18">NPC intracellular cholesterol transporter 1-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Npc1-L4</name>
        <name evidence="18" type="ORF">Hamer_G021475</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>cholesterol(in) = cholesterol(out)</text>
            <dbReference type="Rhea" id="RHEA:39747"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024416">
        <property type="protein sequence ID" value="KAG7165268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2C3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030299">
        <property type="term" value="P:intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000008">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004765">
        <property type="entry name" value="NPC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00917">
        <property type="entry name" value="2A060601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="681"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="714"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="789"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="827"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1064"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="17">
        <location>
            <begin position="574"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7165268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1235" mass="137276" checksum="DD63CD0D226A8D85" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2G8</accession>
    <name>A0A8J5K2G8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc finger MYM-type protein 6-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Zmym6-L2</name>
        <name evidence="1" type="ORF">Hamer_G011118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2G8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF19">
        <property type="entry name" value="LOW QUALITY PROTEIN: ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="145" mass="16764" checksum="8E1E7545048FAE90" modified="2022-05-25" version="1">MTWRSRSFLLFAGHNSGMTGHDILNIVNRFFREEEPTWTQCYSICCDRAPSLLGEQQGFAAHVKEVNANGMIIHCPLHRKNLTSIKLPGELAVFMIEAVQLMNFDRVRALNLGLFREVCSDFGFGHTHLQYHMEVRWLSRKKVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K380</accession>
    <name>A0A8J5K380_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Cog1-L</name>
        <name evidence="9" type="ORF">Hamer_G020430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023767">
        <property type="protein sequence ID" value="KAG7165748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K380"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="835"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="845"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7165748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="882" mass="96497" checksum="B6FD1EBA874C717E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3B9</accession>
    <name>A0A8J5K3B9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hexosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Chpf-L</name>
        <name evidence="10" type="ORF">Hamer_G011099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus</location>
            <location evidence="1 9">Golgi stack membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3B9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF13">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7166270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="767" mass="87451" checksum="675C8FA2F8BE594B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3E8</accession>
    <name>A0A8J5K3E8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G002627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3E8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="195"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7168541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="593" mass="68677" checksum="A2F7B1171E7D9D37" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K430</accession>
    <name>A0A8J5K430_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Filamin-C-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Flnc-L1</name>
        <name evidence="4" type="ORF">Hamer_G010426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K430"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000140">
        <property type="entry name" value="FiLamiN (Actin binding protein) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000007">
        <property type="entry name" value="Filamin-B isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000001">
        <property type="entry name" value="Filamin-C isoform b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="90"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="183"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="292"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="385"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="484"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="593"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7166765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="673" mass="71040" checksum="15E72D28D0ECCEFC" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4F3</accession>
    <name>A0A8J5K4F3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4F3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916:SF26">
        <property type="entry name" value="CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="391" mass="43148" checksum="EBDE1C45EC7C03DB" modified="2022-05-25" version="1" fragment="single">CNDMSSGILDDIIFCDDVVGLLWMTTPRLRDLFINLTKLDQVITVRPSPPPSPRTAGDDNGEEVIVFSGSPSVLPWPDRFNMTTNKATVFLLLVCHAIKSTTTAPSHTFLNQGLLQDRTPALTVTGGDIEPSQSNRGEEIRVWREGREGMPEGRGGKETCPPQYPAGEFTIFSFLSFSILIMQFIVNMSINNNNNNNNNNNNNNNLNNNNNNDNQNDNSVNNANVVENAVTGTGMAGRSFPYLPPTAEAPQHTETPQHTTVRQQDALARQQQQHEAPVKTTLSSLTNSSQCVCVHPSESTPKLSSTTLAPIVSHGASCISWLLCIAAQELQAPDELYFVAYKFLISIDELETYLILRDTAKSRVQSPSQLNIENVKDCREHLTKCIQDVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4G2</accession>
    <name>A0A8J5K4G2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 710-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Znf710-L</name>
        <name evidence="9" type="ORF">Hamer_G012821</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4G2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7167373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="123" mass="13590" checksum="F0934D3A74997B19" modified="2022-05-25" version="1">MVGSGEWSAYTTWDVGVIGKQRGGVQPPQCRISSSSIGGLCEQPLPVSPTMGRRHIRTADKVFACPTCGKTFNNAKDCRRHAVIHTGIKPFKCPYCPHRANLKFNLTKHIQAKHKPVQFTTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4R7</accession>
    <name>A0A8J5K4R7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015074">
        <property type="protein sequence ID" value="KAG7169860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4R7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="346" mass="35901" checksum="1B3405251A114C22" modified="2022-05-25" version="1" fragment="single">MQLSREIGLTNFQHKASDATSPPRGNPLTLSSLNCPSTILPFSTAREIQSRFGRRTRNVAATWVPYDDSTSVPYDDSTSVPYDDSTSVPYDDSTSVPYDESTSVPYDDSTSVPYDDSTSVPLPQPSPPPPPPPPPPPTPLPPTPPPPPSLPSPPPLPPPSSSSSSSSSSSTPSSSSFSSFSLLLLPPPHSPTPPPSSFSSSSSSSSSSSNSSFLPSLLPPTPLPPSSLLLLLPPLLSFSSFSSHFPPPPPPPSPPTPPPPPSLPSPPPPSSSSSNSLLLHLLFLLSSSSPLSSSSNSSSSQLLQLLPSSSSSSSSSSSSSLLLLLLLLLSSVPGTLFSHRSLCEYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6L5</accession>
    <name>A0A8J5K6L5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alanine racemase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">alr-L</name>
        <name evidence="5" type="ORF">Hamer_G022758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019676">
        <property type="protein sequence ID" value="KAG7168663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6L5"/>
    <dbReference type="OrthoDB" id="186866at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30511">
        <property type="entry name" value="ALANINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30511:SF0">
        <property type="entry name" value="ALANINE RACEMASE, CATABOLIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase C-terminal" evidence="4">
        <location>
            <begin position="278"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7168663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="423" mass="45910" checksum="8F0F5E2A113FB3B6" modified="2022-05-25" version="1">MTGEESGEVVEPRAADSPTAAGILLQFAAQAFCRVRDASFIHVNLDSVAHNIQVLKSLSGPNTGIMGVVKGGAYGSGMMKVVEVLVEEGVKELSVAKVGEAVYLRKRGINHPITVLGNLSTFELPDVMQYNLIPSLSWTTPLTSVPRDTLVYPDGSPLRVAINIDTGMSRYGVQPCDLRAMVHTLDDLGVSINSMYTHLQGSITEKKKNQKQIDIFLEATEPYKERPLTRHLAATTGCVQDLGTHLDFIRPGGAITGLSSGADRESAQQFANCGFRPAFSVVVRPTYFKLLPAGRFIGYDATYETRGDEWIANFTTGWSDGLSRRLSNGVGAVKRVKTGELCPIVGRVSMDSITVRLPEAPGEDDVFQVITDDFDDVTSAVGMARNLGAAVYEMPGNWSTRLARVYSRNGKIVHVCNALEYEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8Q3</accession>
    <name>A0A8J5K8Q3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Hamer_G013289</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="JAHLQT010015640">
        <property type="protein sequence ID" value="KAG7169668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8Q3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036824">
        <property type="entry name" value="Nucleoplasmin_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69203">
        <property type="entry name" value="Nucleoplasmin-like core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="250"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7169668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="338" mass="37225" checksum="E07B661121C1785F" modified="2022-05-25" version="1">MFWGLTLEPGKRYTKTVDHDFHISAAVLDTSCGDDELVRVIVEVDINEGEIIIANLSQKYGILQTQLDLQFGAGSAVAFYTDGGTAPVHLSGYMIFEDDDFSFEKDGQNLNADGIDVEGGVEEEEEEEEEEEEDEDEEEEEEEEEIVPVKEELDDMVDGKRPGSDKNDKKEAAPEKVEQKKSPTTKSPKKDKLPKDESKTPNKTKEKHEKALVQSPGASQTPSKPPKVVLSGGVTCVDVKVGTGKEAKKGKMLVVHYEGRLMSTKKVFDTVNTGKGFKFRLGKGEVINGWDVGFEGMKVGGIRKITCPPHMAYGKQGAPPDIPPQATLLFTVELRNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KDD1</accession>
    <name>A0A8J5KDD1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tigger transposable element-derived protein 1-like 160</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TIGD1-L160</name>
        <name evidence="1" type="ORF">Hamer_G029848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014392">
        <property type="protein sequence ID" value="KAG7170399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KDD1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7170399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="208" mass="23557" checksum="5215AB2D0C3C4AFE" modified="2022-05-25" version="1" fragment="single">FLITSAWKEVTVRCLCAAWRPLWPECVLQRDFEGFEELEEEAVVHEIVSLGNSMGLEVDDDDVEELVEEHSKELSTEELLELHKEQNETLKWSLTSEESEEEEDKEESRIIPAKDLKDEFFCWSKLSKLAEDYHPDVGSVQKAISVFNDNIMNYFWKSQSCLPCPALPSLPALPLPCPTLPCPDLILPCPALPCPDLPCPALPCPPMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KF27</accession>
    <name>A0A8J5KF27_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enteropeptidase-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G012575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KF27"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="676"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7170999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="963" mass="102821" checksum="68B190F338CA5539" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KIU6</accession>
    <name>A0A8J5KIU6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit beta-like protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Gnb1l-L</name>
        <name evidence="4" type="ORF">Hamer_G026260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017289">
        <property type="protein sequence ID" value="KAG7169329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KIU6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="123"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7169329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="166" mass="18504" checksum="DC6705E87493408E" modified="2022-05-25" version="1">MQARYVKVARKVALVVAYESGHISLWNWNEKNIMSEVDVNESPICLTYDDESRMGIIGTTSEKVYIFNISSNLIISVVKHLFITNGGVSSCVVRLDGKIFVTGGWDSRVRIFSAKRYKPLAVLQYHKKTVECLAYSTSDVEHFGCGLLLAAGSSDNSISLWNIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KM12</accession>
    <name>A0A8J5KM12_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014752">
        <property type="protein sequence ID" value="KAG7170229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KM12"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="240" mass="26742" checksum="BDE7A658DD10B567" modified="2022-05-25" version="1">MLPMKRRRTQQLPNTKRTAADQYSDDQDGDLESEESDEERESELPTKSILSSRKGKASKLGGKTGNTDLAKGKKTQPSTQSLGKSDKLINKLVKSKPAVVSHLGNTETVSKSRSTGNELRKATNKESHDSEDDYESDNLDQENDNDDSDQENDNDESDQENDNDDWDEENYSDGSDEESGSKETNKNRIANTPIQQNDDESSSSSSSEKAMVRPAWLIPNRGQTVQKREDTSEESESESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MFU9</accession>
    <name>A0A8J5MFU9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sodium-coupled monocarboxylate transporter 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Slc5A8-L2</name>
        <name evidence="13" type="ORF">Hamer_G010615</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MFU9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7153319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="312" mass="33060" checksum="8F8760855713E8F2" modified="2022-05-25" version="1">MDKLGHMQGMGGLFVAAVYGGVLSSMSSQANSIACIIWEDFLKDQPYFKTFSNTAATNTVKLLSAVTGILSVGCGLLSGQLGSLFNVAYSINGALKGPLDGVFLTGILVPWANKKGALAGLIISSTFNMWLVIGKFIQGGGTPPYLPLSTEGCLVNGSHPLLINSTTAYSFPNSPTTTVPSSYTSTGINPVASTHNPQIEAIDVSSTSHTIYDISYCYSGIMGVIITMVISSLVSLCTGPVAPKNVNKKLVNLTCARLHHQLWQLLPNHDSYSNDMEDKVAPNLTTSASTGLDDVQQLTKKQTGSREDYPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKU5</accession>
    <name>A0A8J5MKU5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">copz-1-L</name>
        <name evidence="14" type="ORF">Hamer_G021001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043055">
        <property type="protein sequence ID" value="KAG7155134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKU5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7155134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="170" mass="19393" checksum="D537DA695678AA61" modified="2022-05-25" version="1">MLDRLTCVYRSNVDLFFYVMGLSHENELILVSVLSCLYDAVSAILRKNVEKRTLLDNLDIIMLALDEICDGGVPLETDPQVVSQRVALRIEESPFNDQTVTQISISYVMAGLWSRGYPRTLQTQYFLTPLESKTSDPVQRSEYQVRQKLETTTGAVLQSAREQLKWSLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLT0</accession>
    <name>A0A8J5MLT0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G022605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039966">
        <property type="protein sequence ID" value="KAG7156139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLT0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="134" mass="15332" checksum="A2CBC9531AF1721A" modified="2022-05-25" version="1" fragment="single">EGLIIFEFGECGTPEIVCHGGWSLCLLLSREIIVNKDRHPRLPSPDFLRIIVVIKESCEAGIPELVREGTRGIWRTFICDLVALRMVTMRPICVWWCDLSLSQEGKDQKVIKQDSSMIKVWKSVSRLTERHNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMD7</accession>
    <name>A0A8J5MMD7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038820">
        <property type="protein sequence ID" value="KAG7156786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMD7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="417" mass="47342" checksum="9B61A591BD16F912" modified="2022-05-25" version="1" fragment="single">MKLPVVIEAMDRTNLSDRNAVFVAGAVAQALGHDIADMSFSRSTIRRYRASGRKQAAETDRKSFSPDEPLLLHWDGKLLPDVQNTTASRIAIVVTFNGQEKLLGVPKKERETGEAQAEACLEAIKSWNVEKLVKGLVFDTTASNTGLHRGACVRIEDELEQELVWIACRHHVLEIMLSDVFSLICGSTGSPETILFKRFKKQWRSISLNDFIPAPESIFWHEAPMAVRAPFNDLQLMKVLKEYPHEKVAHAAQAAISRHLWYLSEHLIGLSLFDDRIDTETKKNMVQNFQCPKKQDFSRRIVLSDETPISNVASFVTERTLDIFDVLTLDGKERAQLFLSKDPKTWKDDEVFITMRDRAINMKVVNDSAERAIALIERYNESITQNEDQKQYLLQVVAAHRKKLPTASKAAMMKGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMF2</accession>
    <name>A0A8J5MMF2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Paired domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038494">
        <property type="protein sequence ID" value="KAG7156846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMF2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13633" checksum="52D19ACF3D217DEA" modified="2022-05-25" version="1">MSGRVPARDDIAAVIALYKAKHELIDISAQTGVGLHVVQKLVKRYRELRENMLPAPLPKSGRPKLLSPRTLKVISRQAKSNPTLTSREVKERSPCLLSHISLCYVQQSLHDDLGFKSFYAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMG7</accession>
    <name>A0A8J5MMG7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Epc1-L</name>
        <name evidence="9" type="ORF">Hamer_G015851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038275">
        <property type="protein sequence ID" value="KAG7156923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMG7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="14"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="270"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="690"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
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        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="701"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7156923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="718" mass="78244" checksum="C8E6AC0E0683C880" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMS1</accession>
    <name>A0A8J5MMS1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">Hamer_G001008</name>
        <name evidence="2" type="ORF">Hamer_G025204</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7157114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="162" mass="18750" checksum="DB1DE73AB8E671E7" modified="2022-05-25" version="1">MEESESQSGENAKGTVRPTSSTTRSATEIYLVGQPASSIRGSKLPTMRQVLKFFFHTVNESGDRQETFKETVRNVLTFWNLARIKTISERGCREKLTRLWEHWRSLQKSRDRAAKDKVENFKSQLDLLWDIGAPDAVEDIEKNRLLTPADKQQDIAFYQDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMS9</accession>
    <name>A0A8J5MMS9_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038298">
        <property type="protein sequence ID" value="KAG7156892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMS9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="650"/>
        </location>
    </feature>
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        <location>
            <begin position="662"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="768"/>
        </location>
    </feature>
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        <location>
            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
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        <location>
            <begin position="939"/>
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        </location>
    </feature>
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        <location>
            <begin position="16"/>
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        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
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        <location>
            <begin position="354"/>
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        </location>
    </feature>
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        <location>
            <begin position="592"/>
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        </location>
    </feature>
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        <location>
            <begin position="633"/>
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        </location>
    </feature>
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        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="737"/>
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        </location>
    </feature>
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        <location>
            <begin position="948"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1005" mass="108100" checksum="5D17C1DD2DECA820" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMW1</accession>
    <name>A0A8J5MMW1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Out at first protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">oaf-L</name>
        <name evidence="5" type="ORF">Hamer_G005793</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMW1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026315">
        <property type="entry name" value="Oaf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053897">
        <property type="entry name" value="Oaf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053894">
        <property type="entry name" value="OAF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13423">
        <property type="entry name" value="OUT AT FIRST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13423:SF2">
        <property type="entry name" value="OUT AT FIRST PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22873">
        <property type="entry name" value="OAF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14941">
        <property type="entry name" value="OAF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035174507" evidence="2">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Out at first protein BRICHOS-like" evidence="3">
        <location>
            <begin position="47"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Out at first C-terminal" evidence="4">
        <location>
            <begin position="183"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7157373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="246" mass="27787" checksum="142B02DF7F274208" modified="2022-05-25" version="1">MKQHQPVLVVVVMVMTCGCHSQLVVNVNTQSGEVFKETITANISDDSELQIFKVIVLGEEELGQSQYQVMCFILRFFKSNFISSDAMSKLRQKNPGTVRTPEEDRGIEEVELDISVDVARSNILSPHIPHMCALAPSSTYASDRDIKLWATQRRELDGDWSLVSDVTHHLPTRGVARCGDGGRDLSNPCACHYQVCIAWYPCGLKYCKGRDNSGKAVSYRCGIRTCRKCRNFNYFVPQRQLCLWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MN42</accession>
    <name>A0A8J5MN42_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pro-resilin-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">resilin-L6</name>
        <name evidence="5" type="ORF">Hamer_G010077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MN42"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035171539" evidence="4">
        <location>
            <begin position="20"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7157222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="485" mass="53448" checksum="D6D9ED63695755E1" modified="2022-05-25" version="1">MLCVVVFASVAVWSQPQRARQSPISMGMRLLGNLRHGMTRTIQDIFGVGGGRGKETPSERPPFRQQQQYQELNLLLPAIEKPNIATTAPPSSFFTVIHEPEVSTAFPDIRGFTDESFKPNIFLTGATPFQGTVDEDQLPLISSHSEGNAHPLPLAQNHLPSPPQDSFPPHGLSSTGFSTFGSPKPEDVPSESSIPFGNTATFSLGSTFKNSRSQKVFLHSSQSLHIPETAESREILGPAPHNPDAHTNSQSFIGTSVPSQPFIKTTIPSHLDLRANPPAFTRRNQPFQHPEVHTKPQPFTRTSQPSQTSSQGVTLSDHHPTIIIRSQSPSPTHFPTQSFTEHQRGSTTQFERRLTTPAVRPVTREFIRDRLQISKKPVVPVKIGHGHINTGTKMRVTPRENEDGSEGVEVSSYEFGYGVLDSDTGNQFFHAEKREQGQTKGSYKIQLPDGRVQTVTYVANSRGFHPKVTFDGEARYPDTTSTTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNX4</accession>
    <name>A0A8J5MNX4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transposase and winged helix-turn-helix-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G026748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035124">
        <property type="protein sequence ID" value="KAG7158423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNX4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF28">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13551">
        <property type="entry name" value="HTH_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="2">
        <location>
            <begin position="14"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="309" mass="35482" checksum="3A8525EEE6478CCF" modified="2022-05-25" version="1">MLEIYLKDSTIFRGTSSAIQNDLIAAIGYLITKQIKEDIEKTDFVSLILDETSDIINKSQLSSVFRFVDQNCQVQERFLHFTDVSADRSSAGLLEHVKHLLRDFNCGEKLIAQTYDGAAGMDIAYCSKKVEELIGKIKKIREDDFDRIFQESVPGRNDENPNKRSRRIMEVQPQRHVRPPRTRANRPEVIRSRGRIRISRLLGISRDTVRLWVRRYEEGGHVLTRPRPGRPRVTTPAADQQIQRAAERAPLSTAVRITRETGVQCHPITTRRRIRETGRQCFIPARKETLTEAHREARTSSRSPVLAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MP14</accession>
    <name>A0A8J5MP14_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">monoamine oxidase</fullName>
            <ecNumber evidence="2">1.4.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">maoA-L</name>
        <name evidence="6" type="ORF">Hamer_G021620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.4" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010035455">
        <property type="protein sequence ID" value="KAG7158345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MP14"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="5">
        <location>
            <begin position="13"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7158345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="527" mass="57724" checksum="8F92A865E1EB9DBC" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPS6</accession>
    <name>A0A8J5MPS6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ADAM metalloprotease-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G022560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033677">
        <property type="protein sequence ID" value="KAG7159276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPS6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="484" mass="53309" checksum="45F714F257BF8A8D" modified="2022-05-25" version="1">MEPPRRMKPLVDALVSLGLIFLVAVIILFCCWSRIQWWWERTGRPLCLPCCASCIDSCCCPLTTKAIHWILTIRCFKTQKKNVRKEVCQVKEKAKINGEVDLDFKDCSPRTKTWGKADEKLMTEVVTLTPKKSPDIRKNIQLPSRSPVFRHKSAQELDHPTYLQSVSVDSGCIADIEDVDTNITPNSKMSMTSLISVFSKHCSLSSKKAGQNDNQLPRHFERQKSMPLSRFVVDPLVGNRSSRQGSPPPDHMKTNFRRSISSDVTNGRPGWAPLTQPPSNKTYRIDENLQKLPKLADNAFVQSENGNKLVNSSHYGQESVTQTQKKPLMPPRNSSSPPKKVSPIRVAPPPPAPTPAKGDQTKTPSMFLWKGKTGPDHSKLPGTGSDPDTKTKPPRPMHEGKSDAASLGPSKPTRVPLMPPKTSPPKPPKTGPPKPPNKGPLKLPNTGPSKSPNTALQSGAKKNVPVPSGKGVSVKDIARRLEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRV9</accession>
    <name>A0A8J5MRV9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ZBED8-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Zbed8-L6</name>
        <name evidence="1" type="ORF">Hamer_G016351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRV9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF19">
        <property type="entry name" value="LOW QUALITY PROTEIN: ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="119" mass="13527" checksum="3FFC1ABFB2DB2D9C" modified="2022-05-25" version="1">MEENFLFCKQLETTTTGEDLFKLADSFIKEENLRWDHCFSVCSDGAPVMLGARQGFTARVKQVNPAVIVVECLLNSVMEDVIQIVNFIQSSALNSRLFNQMCSDMGSEYEHLLYYSAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSE8</accession>
    <name>A0A8J5MSE8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin lectoxin-Lei1-like 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">C-type lectin lectoxin-Lei1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Lei1-L1</name>
        <name evidence="4" type="synonym">Lei1-L2</name>
        <name evidence="3" type="ORF">Hamer_G014201</name>
        <name evidence="4" type="ORF">Hamer_G014202</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSE8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21407:SF1">
        <property type="entry name" value="RE43931P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21407">
        <property type="entry name" value="RE43931P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="55"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7161632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="196" mass="22334" checksum="693379183EFF0BC8" modified="2022-05-25" version="1">MFTIRNFATVIITFRGANITSVFQMKALLIFALVSVATAQQYGSYGGGGQVDLSLHNSDYHFSWRHDGGKKYDWYSANKYCANLGPGWFGVSIETHEEDKYISQIIAGDYLEYIWTGGYRKGYDFSWPSGYPFSGLNWSHTGANGYPQPDNREDGKEFCLAVLNNFYQDGIRWHDVACHHEKPIICERPRRGGSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUQ9</accession>
    <name>A0A8J5MUQ9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G-protein coupled receptor moody-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">moody-L1</name>
        <name evidence="14" type="ORF">Hamer_G003500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUQ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF74">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="34"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="354"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7164331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="420" mass="47347" checksum="C62A13A014AA509F" modified="2022-05-25" version="1">MTSEDNDDKGSAPDWAIVLTAVTAVIIAILGFFGNLLTILALPYTRRLRHSATYLVVNLAVAEGIFCVTILPISAAHLFTLYMTSGMRPLFDTQGCNVFVFLRYVNIQAELLSIAAIAVNRCVLIAVPKKYPQVFSGPKTAILIAAIWLCSGFLMLIPLLKIYGEFTYNHNTDECDFSDNTKYGQGPRKLFLALGFLLPCVVIIVSYSYIFYKARQSSVKLQSRGSSLVKNTDNSSSDTRPTRPKEGLRSRDIRIARTIGVIFLAFLLCCTPVSVVHYLDSKVKSCAVFGFPQFHMPTLLLLLHPVYWAQYCINIFIYVFMNKQYRDAYVHYISRWWPNFKEVVSRTKFKWKEEPTSGDSRRQSRAATPSSGSRFNVRKFSKNLNPKNNTLDSMESHHGQPGTPKILTKSETPNLADTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVE1</accession>
    <name>A0A8J5MVE1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative helix-turn-helix domain containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Glr-hth-L2</name>
        <name evidence="4" type="ORF">Hamer_G011770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7165875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVE1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="3">
        <location>
            <begin position="27"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="84"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7165875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="193" mass="22448" checksum="CB91FD97B1428F59" modified="2022-05-25" version="1">MVMEVQPQLYVRPPRTRAHLPKVITSRGRIIGYHEAGKGIREISRLLVISRDTIRLWVRRYEEEGHVLTRPRPGRPRVTTPAADQQIQRAAERAPLSTTMRIKRRTGVQCHPTTTRRRIRETGRQCFIPARKETLTEAHREARKMFPEAYADSRRLEEFVHARSQQVERDWSDHITWPQGATLPPSLPPASLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWS9</accession>
    <name>A0A8J5MWS9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.256</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALG10-L</name>
        <name evidence="15" type="ORF">Hamer_G010440</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4 14"/>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWS9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028810">
        <property type="entry name" value="Alpha1_2_glucosyltferase_Alg10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7166778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="489" mass="55971" checksum="6A74B078E1642A08" modified="2022-05-25" version="1">MKNVSKSAGGGERQHSQLVLKNVVNKRQTLSQFSSRTMMGSPQPSFIFPLVIVSFTAVSYVCLVVVYTVQPTPFIDEVFHIPQAQKYCDSKFQEWDPKITTLPGLYLFSIGLNGPVSWVLGRQLCDVFSLRITNLVAAAFMLLTIHKLLIHLHGDRMDNWKVMLSGLNLSLLPVLYWFTFLYYTDVLSTLVVLVMILLHLHHAPTTAAAMGVVAVMMRQTNIIWVGFLCVLMAVDVLGVRVLKAPALMKKIKKAAAKPYRLAEVLADVVVDCFSYGIVLAGFLLFVMYNGSVVVGDRSAHEATVHLPQLGYFCLFFLVFSLPYTPSHVRPFIKLCRRHLAFAVAVLVVGVMVVHSNTLVHPYLLADNRHLTFYLWNKLYGRFSFVRYLMVPVYMFGAYMVHVFIQNRSFVFKALFLACLVASVVPHKLLELRYFIVPFLLARMQYISRNWWQLWIETLYFLLINSLTLYLFVSKTFVWEDLPELQRIIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYA7</accession>
    <name>A0A8J5MYA7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021059">
        <property type="protein sequence ID" value="KAG7168051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYA7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="137" mass="14810" checksum="3E8D1809C8C1A72E" modified="2022-05-25" version="1" fragment="single">SVLPSSYTSRESYPTPTSRESFPHPYTSQRDLPSFLHITASPSPTPTPHSESFAHPYNSVSPSTLLHITVSPSSPLHIMARPSSFLHITAGPSPLLHLTVSPLLTLHNSVSPSHTLHITVSPSTLSLHSGPSHIYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYL3</accession>
    <name>A0A8J5MYL3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NCK-interacting protein with SH3 domain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Nckipsd-L</name>
        <name evidence="5" type="ORF">Hamer_G016772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020459">
        <property type="protein sequence ID" value="KAG7168142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYL3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="124"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7168142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="621" mass="68532" checksum="B5272708A5BC04FC" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZ23</accession>
    <name>A0A8J5MZ23_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enterin neuropeptides-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Enpp-L2</name>
        <name evidence="2" type="ORF">Hamer_G021520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019984">
        <property type="protein sequence ID" value="KAG7168607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZ23"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="217" mass="26364" checksum="419425CC9CEE0603" modified="2022-05-25" version="1" fragment="single">YSHTFIVYSHTFIVYSHTFIVYSHTFIVYSHTFIVYSHTFIVYSHTFMVYSHTFIVYSHTFIVYSHTFIVYSHTFIYHTFIVYSHTFIVYSHTFIVYSHTFIVYSHTFIVYSHTFIVYSHTFIVYSHTFIVYSHTFMVYSHTFIVYSHTFIVYSHTFIVYSHTFIVYSHTFIIYSHTFIVYSHIFIVYSHTFIVYSHTFIVYSHTFIVQSKKTPTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZF6</accession>
    <name>A0A8J5MZF6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G025049</name>
        <name evidence="2" type="ORF">Hamer_G030177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037981">
        <property type="protein sequence ID" value="KAG7157117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010017970">
        <property type="protein sequence ID" value="KAG7169204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZF6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="99" mass="10722" checksum="B2477BEEBC44DC83" modified="2022-05-25" version="1">MNICIRDHTVNTITTSHSINPIITTTTTCNTSGAAALQNHTTKTINSGETRGITTVLRSVTSSYNTASLTTSDYLTHYSLHSQSIGKLSQKMSLSILQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZI6</accession>
    <name>A0A8J5MZI6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hu-li tai shao-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hts-L2</name>
        <name evidence="2" type="ORF">Hamer_G011672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZI6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="68" mass="7547" checksum="BBD93B77C126D879" modified="2022-05-25" version="1" fragment="single">ETVANGDDNEAHHSTVSHSSKEGSPTKDTSLTDDSISKDKKKKKKGLRTPSFLKKKKDKKKEKEAAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZY4</accession>
    <name>A0A8J5MZY4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation initiation factor IF-2-like 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infB-L20</name>
        <name evidence="2" type="ORF">Hamer_G030762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015181">
        <property type="protein sequence ID" value="KAG7169849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZY4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35001">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35001:SF5">
        <property type="entry name" value="PROTEIN CBG01852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1130" mass="117541" checksum="AD80E8327B399AC4" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0L2</accession>
    <name>A0A8J5N0L2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Chst8-L6</name>
        <name evidence="11" type="ORF">Hamer_G028560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010014843">
        <property type="protein sequence ID" value="KAG7170196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0L2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7170196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="219" mass="25116" checksum="5DE96E1BC6F487F6" modified="2022-05-25" version="1" fragment="single">MEILHESSVYKDSRQPTRPKDSGCEASSWSSGFSLQAYGFLTGKRFGTFSRHRLNETKKASSNPERKFITLAKKMLTVGKHVGVVAAVNIGYSATEQSKLKKYFSNASFTMAEFLEHVLWTRDVDLLDHHWTPISQLCGPCTADYKYIVRHENPKEAEYLLGLLHLQENTIPRKHKSIGALHDKSDLQYFEDVPKDLMAIIIDMYKQDFDLFSYDKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0L6</accession>
    <name>A0A8J5N0L6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transient-receptor-potential protein-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">trp-L5</name>
        <name evidence="14" type="ORF">Hamer_G013412</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Timp W."/>
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                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N313"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="544" mass="62291" checksum="02019EF1483668E7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3X4</accession>
    <name>A0A8J5N3X4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gamma-glutamyl hydrolase A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Ggh1-L</name>
        <name evidence="4" type="ORF">Hamer_G007041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3X4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034722">
        <property type="term" value="F:gamma-glutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046900">
        <property type="term" value="P:tetrahydrofolylpolyglutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015527">
        <property type="entry name" value="Pept_C26_g-glut_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315:SF0">
        <property type="entry name" value="FOLATE GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315">
        <property type="entry name" value="PROTEASE FAMILY C26 GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51275">
        <property type="entry name" value="PEPTIDASE_C26_GGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035246779" evidence="3">
        <location>
            <begin position="24"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR615527-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7172796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="154" mass="16315" checksum="B5275B504DCC9767" modified="2022-05-25" version="1">MMVVPRVVISAALLLAALLVTDAQYSYNLRPIIGVLSQAPSDSLLSGLVDKNYTGFIAASYVKYLESAGARVVPVLFLFPGGGVSITNTSGYGAAGQKIYDLVKELNSKGIYVPLWGTCLGFEMLTYLGANYVNLLTACNANNKADPLNLQDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N400</accession>
    <name>A0A8J5N400_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamate receptor ionotropic, delta-1-like 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Grid1-L29</name>
        <name evidence="11" type="ORF">Hamer_G017859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010216">
        <property type="protein sequence ID" value="KAG7172881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N400"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="62"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7172881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="344" mass="38875" checksum="07848949E799C133" modified="2022-05-25" version="1">MLGHVWRGEKDLTINYLTITEERNKYFDFSFPYHNEGYGYSIAIPPPLPRWRSLVYSFTALVWAVMGGVLVLVALVFCALTHLHNPLSFSQCFSSILQSLMNQGMSQVPQEWSLRMFLGGWWITAYVLVISYTCNLIAVLTVPVYPTRITTIQQLAHTYYRSCMLDYGEFVPEALATSTHPALSALGAKLDLMPVDGTREFGGQEGCVGLVLEGTHAHVESFSFLKLLYFLLGHKDVVYFVKEQIYQANLAFFFRRNTPWKYKFDQGIQSLVESGLVHKWYDDIMSDIKKITTTSEEDSGPSEQPLSLGHLQGPFLLHLVGLLSSLTVFLVEYCTFNQAGASTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4U3</accession>
    <name>A0A8J5N4U3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Tigger transposable element-derived protein 1-like 241</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TIGD1-L241</name>
        <name evidence="3" type="ORF">Hamer_G008515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7172999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4U3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="61"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="120" mass="13534" checksum="60F23A7411DF663C" modified="2022-05-25" version="1">MSKAFALIQEGLQIFADNDPNLERNIKIARAVNNAHSSYTELYKEKVSPPVPRPAAQRQIKKRKTLTYAEKLEVVKKINGGKSKRAVALTYGINVSTIREIEEARRVAGRGFDETTYRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N554</accession>
    <name>A0A8J5N554_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Pkc53E-L</name>
        <name evidence="15" type="ORF">Hamer_G020208</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010009370">
        <property type="protein sequence ID" value="KAG7173576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N554"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000023">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="268"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7173576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="347" mass="39216" checksum="67072E9462041B66" modified="2022-05-25" version="1">MAGTSEAANRRTVQGRVAGTSEGLIGRTVQGRVAGTSEAAIGELCKGRMAGTSEAANRENCAREEWQELDRLYFVMEYVNGGDLMFQIQQCGKFKEPVAVFYAAEIAIGLFFMHSRSIVYRDLKLDNVLLDQDGHIKIADFGMCKEGISGERTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKESKDCCKGLLEIQGPVLSQFLTKLPLKRLGCSPKGEEDVRTHPFFRRIDWEKLENREVQPPFKPKITNPRLGENFDPVFRNARLEFSPADKKIMEHLDPDAFHAFTYTNPFYQPVLDEILLPDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N641</accession>
    <name>A0A8J5N641_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pinin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PNN-L</name>
        <name evidence="11" type="ORF">Hamer_G017981</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009070">
        <property type="protein sequence ID" value="KAG7173695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N641"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="10">
        <location>
            <begin position="171"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="34"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="189"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="431"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="594"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="657"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="671"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="705"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="740"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="752"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="798"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="832"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="881"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="950"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7173695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="980" mass="110758" checksum="54A35D46B47FC434" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6T7</accession>
    <name>A0A8J5N6T7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007332">
        <property type="protein sequence ID" value="KAG7174695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6T7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="148" mass="16668" checksum="6A611C7508A63AB0" modified="2022-05-25" version="1">MNEPDEWSCQQGGKVDVVVVVVSAWGGRERKDVSNSESSECCDGRYPQPKVISLRLWPDQHIQYTHRSLVTATPSRSTVNSQPHDRQQPASRMTVSSQPPNHRQQPATKPPSAASHQTTVSSQPPNHRQHITHLRQWTINNITNSYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6W7</accession>
    <name>A0A8J5N6W7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trichoplein keratin filament-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tchp-L</name>
        <name evidence="5" type="ORF">Hamer_G003091</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6W7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043596">
        <property type="entry name" value="CFAP53/TCHP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183:SF2">
        <property type="entry name" value="TRICHOPLEIN KERATIN FILAMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183">
        <property type="entry name" value="TRICHOPLEIN KERATIN FILAMENT-BINDING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0416">Keratin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="89"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="429"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7174189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="527" mass="65335" checksum="CD9016B3A77E0AB6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N781</accession>
    <name>A0A8J5N781_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ubc-1-L</name>
        <name evidence="9" type="ORF">Hamer_G003390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N781"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000004">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7174446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="159" mass="18044" checksum="D947B9E5C10284CD" modified="2022-05-25" version="1">MSTPARRRLMRDFKRLQQDPPAGVSAAPTENNIMIWNAVIFGPHDTPFEDGTFKLTLEFTEEYPNKPPTVKFVSKMFHPNVYADGGICLDILQNRWSPTYDVAAILTSIQSLLDEPNPNSPANSLAAQLYQENRREYEKRVAAIVEQSWLNFQVSATID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N880</accession>
    <name>A0A8J5N880_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G018078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007025">
        <property type="protein sequence ID" value="KAG7174763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N880"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="110"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7174763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="188" mass="21468" checksum="A2AA64A579D77D62" modified="2022-05-25" version="1">MNLPIQEITQNRGTSSPLQQITRNRTTNTDRQQTHDHRQERQHPEERRRKNSRGSTSCSSLRAGAKETATTPNGRGGERLNHERREQLQHQRRGDNDRIAPPLCNLKITQWNVQGLSNKRHTVQAAVIANNIDVLILQETMTSKNKQFRLPGYQQYSVPKGPNSHGSMILVRATIPSSEVEPVYCEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8A9</accession>
    <name>A0A8J5N8A9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G027978</name>
        <name evidence="3" type="ORF">Hamer_G028598</name>
        <name evidence="2" type="ORF">Hamer_G029024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034291">
        <property type="protein sequence ID" value="KAG7158846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010013713">
        <property type="protein sequence ID" value="KAG7170751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010004651">
        <property type="protein sequence ID" value="KAG7175731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8A9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7175731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="72" mass="8119" checksum="179D733864310429" modified="2022-05-25" version="1">MKLMQRMVDVTQQVVRHTTTPLHVVVKVRDVATTYHSTVRAALDGPSFHEHPHDSGHQPGRRTHLSLSVFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA22</accession>
    <name>A0A8J5NA22_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004867">
        <property type="protein sequence ID" value="KAG7175663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA22"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="344" mass="39020" checksum="74958F6B7827AA67" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIRERAQKKKMKSEEAIQREEELCQDVYHFFDSSSDEQEATSDDSSKEPSEPLPKKMKYNTRNISNIALASIRHHAGLQGYARSEAVLQAMLCSQYCQSRTEAVEIRGTLIDDDQLGDCSFHSRKVPPINVNATKLSELVDLSLVVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBL2</accession>
    <name>A0A8J5NBL2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP synthase subunit a-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ATPase6-L6</name>
        <name evidence="12" type="ORF">Hamer_G026369</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003392">
        <property type="protein sequence ID" value="KAG7176469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBL2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00310">
        <property type="entry name" value="ATP-synt_Fo_a_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="entry name" value="ATP synthase, F0 complex, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="F1F0 ATP synthase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7176469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="215" mass="24234" checksum="264AF6A16A8987DC" modified="2022-05-25" version="1" fragment="single">VQHAKEVFFFFFFFFFFFFFFFFFFFVFSEYGAQNDVFVSLPRRNNTLFDESLEKPESLKIVTGVSTPSTSTVPCDKKRRKVPTSGSFAKLSWKRLKSREARTETALSHASPFVETNAIGMLSALLKPAITPTETLRNIIRPGTLAVRLVANIIAGHLLLTFLGNIGPSLSLTLVSFLMLAQILLLILESAVALIQSGINLSLLTEFSFFPNYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NC06</accession>
    <name>A0A8J5NC06_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NC06"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="279" mass="30139" checksum="52342DEA18B47CCC" modified="2022-05-25" version="1">MYSAMLYCVLSHCKSILAMAGQEESQSTPALIHIPESSSGMTFLGGVNSEMGAVGGSGGPVGGVPENNLRESCTRLSISLEENGLYKGNGQDSSSGSSHSALRMTLDELRQVNRYAESTKSLSYLPQVHERQTGRMRTRSEWFLSHSPHASPLTPVDVECQPHAVYILRSGSINRPPSGGGSSENVGSSVRRSSSKDKDRKLVRRSSSKKDKENGQKGSRGRSSSADVKTPPHAGDYMSSPRRRATPPVPDPSPALTDHDCTETDVQRVHVSLTYKPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T038</accession>
    <name>A0A8J5T038_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SPARC-related modular calcium-binding protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SMOC2-L</name>
        <name evidence="9" type="ORF">Hamer_G014704</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T038"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF3">
        <property type="entry name" value="NIDOGEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Kazal-like" evidence="8">
        <location>
            <begin position="183"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
        <location>
            <begin position="218"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="254"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7171569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="351" mass="38828" checksum="096F73FD736D5E4E" modified="2022-05-25" version="1" fragment="single">MWKAAPSVLNHPHVDPPDPAYCFTVLAPSVSVGVICRALNTFGPLGGGGLEAKAGLAARRRKKRKQEEEEKGMKTRMKWKDEEEWVKEEEGEEEEEKEEEQEEGNSRHLARQQVAVTRAVNVYWTVTATWRPRGRDDVICLQTLHHVGALDVPDGWLKIAISGNKYIGNPRCNADMVVIRDDLEHHVDCNVVCQDNSRDPVCGTNGQTFDSICDLDLAEKCLDERRAKQEQLANGESVYVPTCLADGSYAAVQCHNFTSYCWCSRLDGKPIPQTIQKERSPQCVDRTSPPAPESPPQGKWTGVVGEEPGVQAVQTLMSLSTAKASTARPRPRPPQPGPSASLPLLTVRRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T400</accession>
    <name>A0A8J5T400_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox protein Hox-A1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Hoxa1-L</name>
        <name evidence="10" type="ORF">Hamer_G022030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010848">
        <property type="protein sequence ID" value="KAG7172515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T400"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000113">
        <property type="entry name" value="homeobox protein Hox-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046327">
        <property type="entry name" value="HXA1/B1/D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="210"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="212"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7172515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="358" mass="38727" checksum="B6A172FB00ED81F1" modified="2022-05-25" version="1">MKIVGQAVGASGAHTGARTVKPTQTENEFNKRATQKRQTHIGYTGCWFHFGATVVGDPFVVVGGVSFSTFLLSHNHRYHRHYYYDPPPPPSFLIYHPNTTKSPSNTPTTTTAPHNPPTPPSKLLQPNPQRPLNLPPTTTLQHPQPPHNGRFEDLPLHPPPPPHYQSSVFRVLSCFTSDLSLSLAFFNNYYTNNELSPKTDYGGFGGGTGRTNFTTKQLTELEKEFHFNKYLTRARRIEIASALQLNETQVKIWFQNRRMKQKKRMKEGLIAPDPPAVSTPSENSNDSDSTANNSGSTGGTSGGSSGSSSSGGSGIVTTKPESPGSVSGGSGTSQPLQVPTTVTKSKAQALPATTQSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TB08</accession>
    <name>A0A8J5TB08_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G018006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009070">
        <property type="protein sequence ID" value="KAG7173716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TB08"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="ISXO2-like transposase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7173716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="490" mass="55136" checksum="895368A67AAB6165" modified="2022-05-25" version="1">MVKWVHVMYLWSEPNHHRGRAPHSPIWVFGIGDTSRSPSVGYMEIVETRDAATLLPIILKVVQQGSVIHSDEWRAYRNIQGLGYTHRTVNHSVNFVDVNTGVHAQTIESYWNKNKSYIKTMRGCKRSFLNSYLQEFIDRGVSEEKRQSSSVSEKKQKRTLDEEYRPLFLCVSVVGLHPLKKDAGGGAYHVSVRGVICAVVMTLLCLVCVSGMVAENIATSLPYWFIVITTPVGCGYAFCIFAYFQTGWNTHTMKTYMESLRSLPVKKGYPQWTMVMTSVVYPIIHAVLTAILVPEWKLALPSLFVSTSVPALLDVYMGSFIWVLTRALEDLGREVQTRASWRPADVLSVSSQWMMISKMLVTHNKDEGLVRGVRKAVYRTPPASSQQHALSALATRLEARPGRVEVWGMDSLSSSTFVSLCGLVLTYLLVLIQFCPKNNIDWVADNTSTLFQRLNTCFEASDGGGDDTHSWDDMRGDLLNNGSFFLSFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKK0</accession>
    <name>A0A8J5TKK0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ABC1 family-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G000251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKK0"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF28">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="158"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7177031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="566" mass="64687" checksum="C4E4531406335F37" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKU1</accession>
    <name>A0A8J5TKU1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tigger transposable element-derived protein 2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TIGD2-L1</name>
        <name evidence="4" type="ORF">Hamer_G000457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKU1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF26">
        <property type="entry name" value="TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="39"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7177196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="269" mass="30815" checksum="3AEFE107D6CE204C" modified="2022-05-25" version="1">MSEVRNVNVGSGSGGKNGHREGQQGKPQAKRDYRKGVKKRKYTLEMKQEMLEMIKNGARTRTCEIMRRFNCPESTIRSLKKNKKALTASVNVFSRFSSNKTFSETSQQYLLLVITEHHFTIAQKKRVNSPPPFNASVGWLAAFKKHYEVKFAHYYGESTSDDVAAAEKYLAVFQAFVKVSGYCRDQSFNCDKTGIFWKRSPKTTFTAKDEKQTRGVKTLKDRITVLFTANASRDFLMKHLAVNRAARPRAYRHANKSQLNVYWTSNKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TM24</accession>
    <name>A0A8J5TM24_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative iGluR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006330">
        <property type="protein sequence ID" value="KAG7175097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TM24"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="162" mass="18670" checksum="FE8C95F0580C063D" modified="2022-05-25" version="1" fragment="single">VTDQWRLEIIRGEYRLRSSSFVWRSMILRKYLTLLHFALIPRSQIETPVAEPLQTFHQRCGCKSSCYYTCNCGLSHDYSSRRVREVRGRLGPGTVLQEVIVTLAESDSFQKQFQPFVVVAAWLMFAFVISSAYRKILTASLTLPNIPSRPESVQELVPLIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TNW9</accession>
    <name>A0A8J5TNW9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Autotransporter adhesin BpaC-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BpaC-L7</name>
        <name evidence="1" type="ORF">Hamer_G029698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003848">
        <property type="protein sequence ID" value="KAG7176192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TNW9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1010">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="entry name" value="Serralysin-like metalloprotease, C-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="Adhesin YadA, collagen-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="468" mass="51829" checksum="C8AE3CCE951FB215" modified="2022-05-25" version="1" fragment="single">EHITITGEHIKITGEHIKITGEHIKITGEHIKITGEHSKITGEHIKITGEHIKITGEHIKITGEHIKITGEHIKITGEHIKITGEHIKITGEHIKITGEHIKITGEHIKITGEHIKITGEHIKITGEHIKITGEHIKVTGEHIKVTGEHSKITGEHIMITGEHIKITGEHIKITGEHIKITGEHIKITGEHIKITGEHIKITGKHSKITGEHSKITGKHSKITGEHSKITGEHIKITGEHIKITGEHIKITGEHTKITGEHIKITGEHSKITGEHSKITGEHIKITGEHIKITGEHSKITCERNKLTGERNKITGECNKITGEHIKITGEHIKITGEHSKITCERNKLTGECNKITGECNKITGEHIKITGEHSKITCERNKLTGERNKITGECNKITGEHIKITGEYSKITCERNKLTGECNKITGERNKITGEHIKITNGSNKITGEHIKITGEQKTLHLGAKMTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TTK0</accession>
    <name>A0A8J5TTK0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TTK0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="252" mass="26699" checksum="4E6D67A07856BE24" modified="2022-05-25" version="1">MEAVQGVLDDDPDKPRRQQSNEASTSGTSGQSFSWGSATVPTLPAVLSLLQREHMLASTQGRSSANEATDNITSLSWSNTKFSHTPGFQQQLKESGNMQGITSSTCSSIDTSDNVTSQPWSNTQTPQLPTYNPPQEQQDNLPGSSVCTSQDTTNNVSVQNWNPTGDLDLPVFHPLAECDNLPASSSDRCLSSGTNENNTAPQAWSSTAAPPHLPTIHSSQNLENLTGVASSTCPSNDTVDSGTSHSSTSDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TU32</accession>
    <name>A0A8J5TU32_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G000336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TU32"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035216365" evidence="2">
        <location>
            <begin position="18"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="415" mass="47021" checksum="1FD265F8EDCDBFC4" modified="2022-05-25" version="1">MLVKWLTWMATLVLVMSGRHSAGLVSATTDLDVMEEVSHALHHVAESLADLTSLIISITSSFTTTTTSSSTTTTTTSSSSTTTTTSSSSSTTTTTSFSSFTTLKPTANTTNITLSAISPTPTTIIMLTTTSTPITATIPHHYTNHHHYTNHHHYTNHHQYTKHHHYTNHHHHTNHHHYTTTTTTPNTTTTPTTTTTSPTTTTTPTTTTTPSTTTTPHQAPPHQAPPLHQPPTHHHYTNNHHHYQAPPLPPTTTTTPTTTTTPLHHHHNNTKHHHQPPPLPPTPLHQQPPLHQAPPLHQQPPLHKYHHYTNHHNHPTTTTTLSTTTTRSTTTTTTITTTPSTTTTNNHHYTKHHHYTKHHHYTKHHHNTKHHHYTKHHHYTKHHHYTNNHHYTKHHHYTKHHHNTKHLHYQPPPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TU94</accession>
    <name>A0A8J5TU94_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-directed DNA polymerase from mobile element jockey-like 90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002395">
        <property type="protein sequence ID" value="KAG7177363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TU94"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="208" mass="23539" checksum="27A697E8CFB80A89" modified="2022-05-25" version="1">MPQLLPTHVLPLAQSAPGQTYCRHARHSHFDTSERDVTNGRKVPQEASEGKQHLRHRQYVPNNHPVAEPPTFAIPTVIKYKIPKETEFNHAYEVVVALELEYKNIKFSVKPNLVGDLILSPQDHNTAKILSEVTNINGNTVKKIPLDPEEKTTRMVLLRYPLELPVEVTIKHPKVTKAERCVTSQDKAQTKQVLVDIKGTVPEEVDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TVG8</accession>
    <name>A0A8J5TVG8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001348">
        <property type="protein sequence ID" value="KAG7177887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TVG8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="48" mass="5448" checksum="265990DF3B172E3A" modified="2022-05-25" version="1" fragment="single">GGKTTPEELSTLPVRFVQALTQTNKIKARRIEERCRILFPTAFGLFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J3R6</accession>
    <name>A0A8J5J3R6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G009339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J3R6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="67" mass="7635" checksum="244EA5A72F7FBA95" modified="2022-05-25" version="1">MTNGYITTPDDNGYITTDQMTEGYITTDQMTKAASPPTQMTKATSPPTPDRRLHHHHQMTNYIHDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J856</accession>
    <name>A0A8J5J856_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative Transmembrane protein 237-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Tmem237-L</name>
        <name evidence="12" type="ORF">Hamer_G020085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the transition zone in primary cilia. Required for ciliogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM237 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045843">
        <property type="protein sequence ID" value="KAG7154021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J856"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029409">
        <property type="entry name" value="TMEM237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28388">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28388:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15383">
        <property type="entry name" value="TMEM237"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7154021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="314" mass="35624" checksum="5F4816CCA49E7F42" modified="2022-05-25" version="1">MKRRPRRKRKDQKENESQILMTSNSNEKSYISLQLKEMDDDIIEVTREDNDCVLSAPRLLLAASTSDAHNNISTIYQEKLDGFVVARNEFSGVYKKSEDIHDVSQVPTRSSHAIFIQGGFRTFSVLCQGLLAGITHIVSCIPSPPQSQLLFVTSCNRNQFYTFVHQIQHKDMILKIFLLDDDPSNIPSLYPPTMAHVFFTLVIFLTTICLVAACDRSDLIGLGVFSGHGIKVPWTTAFYISSLVLSLVARRTENLLINFSIYQSSGFSTKEVTDLMDWWRWICVARSLSVLAWLAVVPDPHTDALLDYIQDFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J8Q4</accession>
    <name>A0A8J5J8Q4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Manganese-transporting ATPase 13A1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Atp13a1-L2</name>
        <name evidence="10" type="ORF">Hamer_G026312</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044763">
        <property type="protein sequence ID" value="KAG7154231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J8Q4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7154231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="630" mass="65778" checksum="D8B8EA8F9B348651" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J934</accession>
    <name>A0A8J5J934_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho GTPase-activating protein 21-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G015074</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J934"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000058">
        <property type="entry name" value="GTPase-activating protein pac-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23175">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23175:SF23">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="187"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="895"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="798"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="927"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7154712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1050" mass="114668" checksum="9656F653F6ED8E5E" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J9N4</accession>
    <name>A0A8J5J9N4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046571">
        <property type="protein sequence ID" value="KAG7153554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J9N4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="123" mass="13819" checksum="B2C6F5F0C6C8ECAE" modified="2022-05-25" version="1">MRRSPTVSWSGVLPYSEAESYPILGRNSTVFLGGFLPSSRRESYPILGRNPTVFWGGILPYSEAESYRVLRRNPTLFWCGILPYSGAESYPILGRNPTVFWSGILPSSVAKSCRILRQNPNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JB79</accession>
    <name>A0A8J5JB79_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G025209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041500">
        <property type="protein sequence ID" value="KAG7155487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JB79"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="76" mass="8448" checksum="ADF98691DE9BDAA0" modified="2022-05-25" version="1">MNGLRTSDEVNLNNNQLMLVEEEVWRLLLQEGVNLDLIILSNVVCDIAWIILNTDYLNLVNRGLPAVAEASGGPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCY3</accession>
    <name>A0A8J5JCY3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bladder cancer-associated protein-like 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Bladder cancer-associated protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Blcap-L1</name>
        <name evidence="9" type="synonym">Blcap-L2</name>
        <name evidence="8" type="ORF">Hamer_G018497</name>
        <name evidence="9" type="ORF">Hamer_G031785</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a tumor suppressor; induces growth arrest at G(1)/S checkpoint and apoptosis via RB1-dependent and p53/TP53- and NF-kappa-B-independent mechanisms. Modulates expression of genes involved in the regulation of proliferation, cell cycle and apoptosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BLCAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043933">
        <property type="protein sequence ID" value="KAG7154769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010002351">
        <property type="protein sequence ID" value="KAG7177374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCY3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009598">
        <property type="entry name" value="BCALP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259">
        <property type="entry name" value="BLADDER CANCER 10 KD PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259:SF1">
        <property type="entry name" value="BLADDER CANCER-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06726">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01396">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7154769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7177374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="75" mass="8312" checksum="42B3B6E9D36B8E29" modified="2022-05-25" version="1">MYCLQWLIPVLLIPKPVPAGLLHNHVVFMVLYLTGFFLERKPCSICSLVFLAAVTVLCYSGIGNCLLWPTADCQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDK5</accession>
    <name>A0A8J5JDK5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Parkin coregulated protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Pacrg-L</name>
        <name evidence="2" type="ORF">Hamer_G015674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043233">
        <property type="protein sequence ID" value="KAG7155069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDK5"/>
    <dbReference type="SMR" id="A0A8J5JDK5"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207:SF2">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="317" mass="35684" checksum="BDF2F244F53C7F01" modified="2022-05-25" version="1">MTSLQQQSPAVRRGRARGRSQSQPASTRPLSITPHNNGHTTPASVGNRTGRKEWTIHGVSTRRHHSAQPDPKAYPGDRRSLGSPAPSSCGSTSSSVRTVEAFTPASRMRGARVSGPPKLGVFRPRPAPPTTFRRMYERGDVPVTLHHDHHGHNLRWKVEVEKLDYHHYLPLFFDGLRETTHPYDFFSRAGIRDLLARGGDKILPVIPQLILPIKSALNTRDVRVICTVLKVLQELVMSAPLVGESLVPYYRQILPTLNLFKHKNVNSGDEIDYSQQRRENLGDLIQETLEILERHGGRDAYINIKYMVPTYQSCVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JE36</accession>
    <name>A0A8J5JE36_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LARS-L</name>
        <name evidence="14" type="ORF">Hamer_G021973</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010043253">
        <property type="protein sequence ID" value="KAG7154961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JE36"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000326">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054509">
        <property type="entry name" value="LARS1_ULD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008957">
        <property type="entry name" value="PRK12300.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22947">
        <property type="entry name" value="ULD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="51"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="179"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="820"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="13">
        <location>
            <begin position="970"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase ubiquitin-like" evidence="12">
        <location>
            <begin position="1095"/>
            <end position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7154961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1205" mass="137456" checksum="AF8499A267C8420B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGQ4</accession>
    <name>A0A8J5JGQ4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGQ4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035317878" description="HTH psq-type domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13570" checksum="F964D5B6B5C5F344" modified="2022-05-25" version="1">MALFGITRPSTHIVIGLAAWSCDVARAVQEERVEWVCSFPPCSPQCADTVYSHEVLQYSIYCTCIAPCIMPPKHPLRSPGTSGVKKRKAITIEITMDVLKRRERGERTADIKCAFELGESTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JI36</accession>
    <name>A0A8J5JI36_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035078">
        <property type="protein sequence ID" value="KAG7158427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JI36"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="138" mass="15234" checksum="42AE6FE0B8885A21" modified="2022-05-25" version="1">MPNWLSSYGPVLLRRHVRNSKYDPLVDEVELLEANPRYAHVRFPDARQSTVSLRDLAPAGQAVPDTADPEPEPTELPKASTSVPLEPTPGTPGAESPVRDDLSSDARLHEAVLTDSPSLPRRSGRVRRKPDFYGFPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIK7</accession>
    <name>A0A8J5JIK7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA guanylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Rngtt-L</name>
        <name evidence="16" type="ORF">Hamer_G021103</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010036637">
        <property type="protein sequence ID" value="KAG7157861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIK7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17664">
        <property type="entry name" value="Mce1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000291">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000040">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000040">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017074">
        <property type="entry name" value="mRNA_cap_enz_bifunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036958">
        <property type="entry name" value="mRNA_capping_HCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="15">
        <location>
            <begin position="114"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="186"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="11">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="12">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="343"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="463"/>
            <end position="465"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="533"/>
            <end position="538"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR036958-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036958-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7157861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="577" mass="66791" checksum="93944F96329AF6A9" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIM8</accession>
    <name>A0A8J5JIM8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036242">
        <property type="protein sequence ID" value="KAG7157891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </evidence>
    <sequence length="229" mass="25367" checksum="637FCFE5E5331698" modified="2022-05-25" version="1">MRTCRVVEGLGMNLRRTCSIGMTSSIVASSSCCYCVGASSIVVSSICCYCVEMREGFAKDLQGLARLCRRLREGLADLQTCRGLVILCRRVREGLALVVVVVVVVKEGLAGTCSDLQELAGLCRRERKRLGRTCCVAVVGGMFYRRLALCGRNDLERHAANNLREGKDSLYRGVGVIEGLAVICRRLAVMCRRVRERLTVMCRRVREGFAVICRSGRTRKDSLSCWSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JK75</accession>
    <name>A0A8J5JK75_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Patched domain-containing protein 3-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Ptchd3-L2</name>
        <name evidence="9" type="ORF">Hamer_G012045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JK75"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF130">
        <property type="entry name" value="PATCHED DOMAIN-CONTAINING PROTEIN 3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="824"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="863"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="911"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="948"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="402"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="852"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7155908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1022" mass="112917" checksum="FD21A1D630CD501D" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JK76</accession>
    <name>A0A8J5JK76_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032606">
        <property type="protein sequence ID" value="KAG7159717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JK76"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="239" mass="27847" checksum="7ED88A05BC8BC069" modified="2022-05-25" version="1" fragment="single">MAKGIYALKIYLFKHQFTLSTREENNITQLALFVSIMYVRFWHEAPMAVRAPFNDLQLMKVLKEYPHEKVAHAAQAAISRHLWYLSEHLIGLSLFDDRIDTETKKNMVQNFQCPKKQDFSRRIVLSDETPISNVASFVTERTLDIFDVLTLDGKERAQLFLSKDPKTWKDDEVFITMRDRAINMKVVNDSAERAIALIERYNESIMQNEDQKQYLLQVVAAHRKKLPTASKAAMMKGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKW9</accession>
    <name>A0A8J5JKW9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 8">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Ca2-L1</name>
        <name evidence="10" type="ORF">Hamer_G020677</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="JAHLQT010035785">
        <property type="protein sequence ID" value="KAG7158073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKW9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="9">
        <location>
            <begin position="34"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7158073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="399" mass="45091" checksum="3CB7D4A0C71B0B5B" modified="2022-05-25" version="1">MRLLVLVLCNSHYKVTVEPAQSQLLRVLELPPSPQWSYDDVKSWSKVAPQCLGSKQSPVDFTKVKEFTPAPFVFTNYGLIDTMLENNGHSLNVKLFPDPSNRPAVSGGGLPGTYLLDAFHFHWGTTRDKGSEHLLHGCSFSGEMHFVHVKEEYGTVQEALKHPDGLAVIGVWLEESRFEPEVSSFSQDLISQGDCYFRPVGHGTNPRCNYTPQDHQTATQHWFTYLARMTTLPDDTVTPINLRQLLPFDPSIFYRYNGSLTTPPCTENVMWTVFRRPLLVSPFFFSSLRQLPAKNHNKEKLGHPTNTIGAEYHMVDYEDHLLSGHKYITNNFRPVQPLGDREVLFSYGQKEGNKINSQPGGGGLGVRWAQEISFVMKLTDSRSGPGIVYSQRLTIAVFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JL90</accession>
    <name>A0A8J5JL90_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Neural cadherin-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036809">
        <property type="protein sequence ID" value="KAG7157799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JL90"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="229" mass="24435" checksum="A5D934A9EFB302F1" modified="2022-05-25" version="1" fragment="single">MRDRTGLLDDGIFGGAFKEGGGRLGTLVEAVKEVLRGEEEEEERDENLTVQVVSVYGHHPHALTDSSTSSSNTFSSSTPSSTREGGQLKDVPLPRPSTCVWLSVKEATGRFVDPVKLQGLLNLHTRQDMATIEAEGGVVGGGGAQDTLLQTRPLHPHQRPSLPASLDLGGGVSDPSSAATQASTALPLQVVDTNVTSLSPTPDPRHRLPARPRDLHAHLLPERWPLSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLJ1</accession>
    <name>A0A8J5JLJ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G021131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032328">
        <property type="protein sequence ID" value="KAG7159751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLJ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="86" mass="9828" checksum="D9C9B00F8AD2FB42" modified="2022-05-25" version="1" fragment="single">MREEEGDDEEEEEENEKCGGGGGGEGGHEEKANEEEEKIEDEKNEEEEEGENEEENEYEEEENEKLSGNRISSVSPKAFHRLPLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLN6</accession>
    <name>A0A8J5JLN6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydroxysteroid dehydrogenase-like protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Hsdl1-L 2</name>
        <name evidence="5" type="ORF">Hamer_G008938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLN6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000137">
        <property type="entry name" value="Hydroxysteroid (17-beta) dehydrogenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052149">
        <property type="entry name" value="17-beta-HSD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44889">
        <property type="entry name" value="INACTIVE HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44889:SF1">
        <property type="entry name" value="INACTIVE HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7158291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="358" mass="39656" checksum="592ADC8AA2309655" modified="2022-05-25" version="1">MLMGTDVATVGCQVLCNHSHSSWQQSLVHTSVRRTSTMFSEELLQGLEYGGKLLQGFGYVKDVFAVIGILYVGKVTTYLLYDVVTGVRTLFWSRLWDKRLVAKYGKWAEYAKKLAQGGMNIILISRTMEKLKKVETEIADEYGVETEVVQADFSQGRVIYEDIGKHLQDKEIGVLVNNVGGVANLPTKFGNLTDHDIWAQVNVNVASVPAMTNLVLPGMLARRQGAIINIASITCHAPVPYLGIYSATKAFVDYFSTSLYGEYSDSGLTIQTINPGYVSTNLTSFSDYVHTPGISVPTASTYVNSAFSTLGYSHRSSGYWSHACITYIIDNIFGRWMTSYLSGAFEAFLERDAKKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMD3</accession>
    <name>A0A8J5JMD3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vitellogenin-like 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">vit-L11</name>
        <name evidence="2" type="ORF">Hamer_G008816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMD3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37860:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37860">
        <property type="entry name" value="AGAP008810-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFD" evidence="1">
        <location>
            <begin position="109"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="345" mass="38312" checksum="14AEA83C2AD711BD" modified="2022-05-25" version="1" fragment="single">MVKREVDALMQQYPVEYEAIKEVMAKVGGVLLSDLDTLRHDPVTLLTAILIFGNVDELMQKVKLNAITMLYDILWAYDSHTTLPFNNVMWIIYTLQPPRVTDLLPPHTRTAMVVGDTEILTFDNAKLRAPISPCKVVLAAYASNKLTMAHPQPSAPPQITLSTRTTTVTIKPDFRVDVNGREIGTSDVTIGELTIEQSNLQVKLISPFMIVRVATKERVVSLEVSGWTFGRLAGLLGTYDGESGNDWTMPTGIQASTLQELVTSWQEDQQCHAPDVSLVSPAQVTTERLFHCYPLLGVWSRCNSLVRPEPFIHLCYTTTDPCYAAQAYRTMCTTKGIGPLVPRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNW7</accession>
    <name>A0A8J5JNW7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G014224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNW7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="192" mass="21295" checksum="573B3B1DFF0342F0" modified="2022-05-25" version="1">MPFNLDVLQNSSQLLHVTLQCESSNSEATDQQPDAARHCCCIGDTMTLALTSDPDNELRLVHCHRAASPAEDVTTKERNYEVGKAECLTWGAYPASIDNREQDQTASGIPAPLITQLPTGLYGKTQIFLGLTDRDQEEAFVWEDTNQPPVYTKRRLETMSSEAVGQRRSGTVRIKGNSLLEETHQAGKKPFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPG4</accession>
    <name>A0A8J5JPG4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Hexc-L4</name>
        <name evidence="12" type="ORF">Hamer_G017405</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7159963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPG4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035281764" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="31"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="60"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="211"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7159963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="612" mass="69045" checksum="0F11182B003CE640" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ64</accession>
    <name>A0A8J5JQ64_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028106">
        <property type="protein sequence ID" value="KAG7162045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQ64"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="343" mass="39389" checksum="0136C4E085D021A7" modified="2022-05-25" version="1" fragment="single">MAESVEQGSTIVGDTLVERLEEALLINARQYSALEESQTQVKELKQELQELKQELQHAKNQDTDLGYGVGRDTNPTDPPAESAHSVPQSGNDTTHPGSLRVDPGVLPKLTDMAKRDDRETAVFNLSYVRTLSLETLTGPDSESHIRTFCRQVEWLLKQDGHRVEAALSRMEYSVEQRVLQELDSKKMWDWNTLKQALTKFDTGQNTLSKAWESFMREEYHVEDEPGICVERMKYKLAAIESKFEVIQGKDQLMKDVLYTGLPGQMQRELRRYNQLGISLEPFLNELTKCRDWYLRSQGRGQQHVRQTRQGPVPEAYRAQGDYRRNETDGRPGRSTRGKENNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQF8</accession>
    <name>A0A8J5JQF8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G016620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQF8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF46">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="214" mass="22955" checksum="AFA72B2D45E44527" modified="2022-05-25" version="1" fragment="single">YILWYKGERLVEYDTSGGRIQVVTEADGVSHLLLKDAHPSDSANYTCSPSSGTPASLLLNVIVAPHLPSSSSVLVFPAGVLATLITSLTHHHHALITTTSSTVVGALLWCSQYTVSTSPTDCSSYYYYWILLASGVSMVAGLVLMALIYRVAIICQLRLRSLCQGFVGSTRAGEMGVSAPSRQCGSQWVVVAAVTLALCVSLFLTLSHFSRLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JR29</accession>
    <name>A0A8J5JR29_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine protease-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Hamer_G028704</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027258">
        <property type="protein sequence ID" value="KAG7162717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JR29"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7162717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="287" mass="32614" checksum="6F2E057859D68245" modified="2022-05-25" version="1" fragment="single">YLEVVRDSLATVSEDCNTQIKEAHRELDMLLLHQIGWRTITTEFRLCTPLDARIADDVSNMFSLLAENIEDVVQYNKDNRAFEGVKGTNITIDTICGIMMNEDEEPIDRYADVNSMILDVYGKPCLEHTYHAMIEELQATSWENNESVGGRAWMYQTCTEYGFYQSSDSENQPFGDKFPIEFFIKQCEDIYGPKFNLSLLEAGVKRTNTIFGGRDLKVTRVVFPNGSIDPWHALGITSDISNDATAIYINGTAHCANEYPDSPDDPSQLTAAREEVYQLITQWLNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JR66</accession>
    <name>A0A8J5JR66_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027102">
        <property type="protein sequence ID" value="KAG7162777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JR66"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="134" mass="14064" checksum="30382AC868A12AFB" modified="2022-05-25" version="1">MLFPVQLIQDDDHKSSSGNLTHDAPETQVRNVVLNTGVPCCPRLCLLATALDFPVLACWLLPWTALLCACLLAAALDGSALCLLACLLAAALDGSALCVLLPWTTAPLDGSALCMLLPWTTAPLDGSALCMLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRP9</accession>
    <name>A0A8J5JRP9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Ubr2-L1</name>
        <name evidence="4" type="ORF">Hamer_G001803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRP9"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR-like C-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7160525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="452" mass="50251" checksum="3A3B43D52232127D" modified="2022-05-25" version="1">MHQVDVFLMVWDSAAYTIHTLEETQRNANRALLTALSARQRDCLAALVKFAAYVPLCVKKKQMIEGAVVRLLSYILEGGEAAPCVVEWDTFSLLVTLSLGLPSIFPNIQGIAIGCQQDLHLLQVCFLAHLVQLLLTYEGHTSNSNMEVDDETDEQSDEGTSTTGSSDATWLMSMFTHCRSLANLPTTNVEPQHLLSYVKESCLPFLRCCGLFFHFLTEVPAPEELQSSVWVPESEFYCLLRYLGLAVNQLRPTFIEPALSELVNKWCSDSRVGAMVSGAGSEGCMRSWVRINQLVSLPHDYSELINTVSQFPCPASSGDDSRTPTMCLVCGKMLCSQSYCCQTEFPEGSRQMVGACTYHAHHCGAGTGIFLRVRECKILLLSGRIKGCFVNPPYLDEYGETDQGLKRGNPLHLDAKQYARLHTMWLSHSIPDTIAHTMESNSSVMATEWQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRW7</accession>
    <name>A0A8J5JRW7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EF-hand calcium-binding domain-containing protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efcab7-L</name>
        <name evidence="7" type="ORF">Hamer_G002168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRW7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098797">
        <property type="term" value="C:plasma membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903569">
        <property type="term" value="P:positive regulation of protein localization to ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="6">
        <location>
            <begin position="602"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7163096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="753" mass="84889" checksum="5E3BF9745D52E6ED" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JS87</accession>
    <name>A0A8J5JS87_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Ankrd52-L2</name>
        <name evidence="4" type="ORF">Hamer_G027576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029989">
        <property type="protein sequence ID" value="KAG7161103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JS87"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7161103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="694" mass="78300" checksum="C9F2E713454FF7DB" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSM2</accession>
    <name>A0A8J5JSM2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">COMM domain-containing protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Commd4-L</name>
        <name evidence="1" type="ORF">Hamer_G021667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031456">
        <property type="protein sequence ID" value="KAG7160289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSM2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047155">
        <property type="entry name" value="COMMD4/6/7/8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231:SF4">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21672">
        <property type="entry name" value="COMM_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="149" mass="16224" checksum="7EBCEB821975F4D1" modified="2022-05-25" version="1">MRFRFCWDVDCPDWLLAEIATLSKLAVVAAVRWVLESAAGAVVAAAVLDSELQQLGLPKEHAAAITKVYGDHHQQLLQHLRHTSLKAGGDVNWSSRVMGLAVGGTQKPIVRLSLQNGPSTPTTLTVTPSQLHALIQELTEARQMMESIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JT44</accession>
    <name>A0A8J5JT44_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inhibin beta B chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Inhbb-L</name>
        <name evidence="7" type="ORF">Hamer_G002997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JT44"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13752">
        <property type="entry name" value="TGF_beta_INHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF298">
        <property type="entry name" value="DAWDLE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00669">
        <property type="entry name" value="INHIBINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0339">Growth factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="6">
        <location>
            <begin position="499"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7163756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="624" mass="69534" checksum="4122DA18CBEBEEC2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JT84</accession>
    <name>A0A8J5JT84_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain-containing protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ccdc-L2</name>
        <name evidence="2" type="ORF">Hamer_G013999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JT84"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="244" mass="26844" checksum="100EE5D3F0A97C88" modified="2022-05-25" version="1">MKEILRDTVTKITTLLQSNEASLLQGSADAERVRIQREEASYRQDMTKLDKDLCDLELKVEELRNNVINRRLRVNMSDVENMALILSRSSKTVADLKAKFPILQDGLKGLISAEMEKAFCNEKFLKEEPDKLESALRRCKKLTGTLVTLKRYVSATRLASVQEQRVPPNAPGGGPIVGVANGDPRATSPTPAEDVRASSAKVCVVTHPTGPTPTLTPVPKTAVTHTNKPKSHPPLSRKRTPTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTI9</accession>
    <name>A0A8J5JTI9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029030">
        <property type="protein sequence ID" value="KAG7161515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTI9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="95" mass="10817" checksum="D7B0623D3440DD4B" modified="2022-05-25" version="1">MSKPGSGSDVVSMKLKAEEKEFSSLMATNFGLQMDLMQMFWCQEHLGRRMVAYVLFSGLDLESWFGWWPVGLMQAACGAFGMFVKWRLTRGESFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW70</accession>
    <name>A0A8J5JW70_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G013154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024020">
        <property type="protein sequence ID" value="KAG7165647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW70"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="132" mass="14835" checksum="0A836FCB77B96AA1" modified="2022-05-25" version="1" fragment="single">DLQQLVAAGEIEDAEDDEVQDSKPRELPTSVLSSILRELQLLEDNDYNAEKSRIAVRGVKSFLAPHEQLLCERKTAKQQTLDVFFKSTPKKQSEDTEPQPSTSGIRRFFCPSHATKTAPDDDTDDDDDNSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWI0</accession>
    <name>A0A8J5JWI0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">von Willebrand factor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">VWF-L</name>
        <name evidence="5" type="ORF">Hamer_G020892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023275">
        <property type="protein sequence ID" value="KAG7165857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWI0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF402">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035270133" evidence="3">
        <location>
            <begin position="32"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="4">
        <location>
            <begin position="36"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7165857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="393" mass="44395" checksum="375F62B39F8CB2B1" modified="2022-05-25" version="1">MVTAQVLPMMSKMVLEGIVVLLPLVLSLANALDVGKHCYVFDDPHIVTFDEYRYDWHGACNYSIAQSDFSYNPEVGVFGDFERCWGCASCLRRTTFKNDRNTVITINTGAIFDLMVNGAPYVVPALGIHPVVSPDGVHPVLAWRNGKCVLLQGSSRIVVHHCKHRLDVWAHPSHAEHLDGLCGHYNFYVRDDFTDRSANIHPLEYWPQEFPVSWKTNDQSNPQCLLPRGVIKSCAGRLGNPCRADEREMERYRTMCKRRMMPLIGHQNKLLHYIETCAFDLCMMSGNGADDRMLEEWVIEVLEVLRLAIYILTTTGKTQDATRVRSTSVTTITPTLTVHPINTTFTEGLYTTLTFLETDVTYSETNTITSVRPLYPTSTTTTVDPYDSTYGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWY9</accession>
    <name>A0A8J5JWY9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 135-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Tmem135-L</name>
        <name evidence="8" type="ORF">Hamer_G010976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM135 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWY9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031926">
        <property type="entry name" value="TMEM135_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15982">
        <property type="entry name" value="TMEM135_C_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 135 N-terminal" evidence="7">
        <location>
            <begin position="35"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7166157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="433" mass="49112" checksum="BCD56C7B76D01C6B" modified="2022-05-25" version="1">MNVVLEFAPAITTDTNELTRPSGKYGEPQQDTALHLTGLIKSRKMSFEYGRKLLKDYMTSVCFLTVNAFGRIFRHINFLTASFLPGFIASLMAINVERPERRQLLAIYVTNASECLWNLAVGHGYVRRIPRGEILIFAGTMAVLGYKYRSSSKPFSRLINSILQKIIGPEESGAMISQRQATKPDASTQLTPKQQSWVRRLLSVFTSRHSMCPHKGGCVPHFLWTGVRGFSQGFIIQLAIKLLPSLPQLVRSPRKLYNLLLNRNNIKAGIFLAWLASVFKGTCCAGRWWHGRDEPSHGAVAGVLSALSMYFYSAPSLALYVMWKVVESAYEKGCDDGYLPRIPGSVELLYAVSVGFLFHLGVMEKHYMKLSYWRFLKRLTWGRMNTYNRHLLVPFGLDSARDYSDFWPSYDPDHIGEHVKQLTAEYMSRMGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JX28</accession>
    <name>A0A8J5JX28_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JX28"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="389" mass="43996" checksum="025A63ACF27986EA" modified="2022-05-25" version="1">MEESESQSGENAKGTVRPTSSTTRSATEIYLVGQPASSIRGSKLPTMRQALKFFFHTVNESGDRQETFKETVGNVLTFWNLARIKTLSERGCREKLTRLWEHWRSLQKSRDRAAKDKVENFKSQLDLLWDIGAPDAVEDIEKNRLLTPAHKQQDIAFYQDQRGERKAFMSGNDKIFAAKKRKQEERVEKQRSKQGRFAACEPSSSDSRPQTSVVADTPTEVEMEKKDTAIQPGRYTSKHPYVTVQLPRRILQEPALKELADRLRISNNEIVSVVAAVLRSANPPGDLSEFRISRETARRARASHRRQVAAAQREAFTPPPHAVVHWDGKLVKQPLLHENQPDEPSQPLVDEVNPGDQTYCTLVLQDEGKPQGIDREAACHGMFWSTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXD9</accession>
    <name>A0A8J5JXD9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G013080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024020">
        <property type="protein sequence ID" value="KAG7165582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXD9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="340" mass="37108" checksum="72B03E9D0F9AF369" modified="2022-05-25" version="1">MYNAPFEMGNEIIMNTISKYGKVEGMRLNKYTKGPAAGLLNGTRTFKEDFPAIQLSGEIHSSRAGVKEREESVTVSQVPATTRYGVEREKVPAQTISQNAIDPKGTTHPDCSENAVQETSTTCEAEIHTERNNVDQPIGKISCENMEYDKADDMEPTNMTGTECEVARGGNMDRMEEIVEVTCIKPPNKNKNDTYKKDQNKPGKNELEINGSDDENQAGCQGPGHGNWEKKSKPQRVEVNQSAVGAGHDDAQNSAKSLILICSVLLSKPFLNPLTRSSFSSSLLLTHLSTPLPASLPSTIRATPPPSSRGHKTRISPPAVPFKTLLTSFLPRRLLIGSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZ86</accession>
    <name>A0A8J5JZ86_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related protein Rab-32B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Rab32B-L</name>
        <name evidence="4" type="ORF">Hamer_G010790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZ86"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF39">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7162129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="185" mass="20919" checksum="E49ECDCDEBC476A4" modified="2022-05-25" version="1">MTAVAPVEHSTVPRELQFKVLVIGEFGVGKTAVIRRYTEGHFSPYYKLTIGVDFAVKTLDWDAKTKVTVQLWDIAGHERFGHMTRVYYKYAVAAIVVFDLSRPPTFDAVLKWVSDIREKVTLGDGRPLPVLLLANKCDIDTIRDAMKWLVGRILEVRSNSQAPMPIVRTLAPEDPPEKPTTYCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZ88</accession>
    <name>A0A8J5JZ88_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 12 member 2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Slc12A2-L2</name>
        <name evidence="10" type="ORF">Hamer_G017130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZ88"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF103">
        <property type="entry name" value="SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035294563" evidence="7">
        <location>
            <begin position="19"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="41"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="202"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="9">
        <location>
            <begin position="490"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="9">
        <location>
            <begin position="804"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7167220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="931" mass="102303" checksum="7DF4EF359F56D876" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0K1</accession>
    <name>A0A8J5K0K1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COMM domain-containing protein 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Commd10-L</name>
        <name evidence="2" type="ORF">Hamer_G005148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0K1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037361">
        <property type="entry name" value="COMMD10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12333">
        <property type="entry name" value="COMM DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12333:SF0">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="127"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="199" mass="22479" checksum="A2F562869007F652" modified="2022-05-25" version="1">MLQLTKKLQEGISLVNATDISKVNGVMGRVCVALSSGRSQVFTEEEEEKLSVSLGHTRDQTRQLIHTILHIIQQVNMEYCIDKRPAVLGEHAAGITHDRVEIFTEHWTTNAKPIVDKLRQQSLSEKQLEDVGELHLQTASSCMARQSHPIAHLQLNLSSRSDAGKLASTEKVVMQFDRDQLYNLYDQLEQIQSHLDALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0L5</accession>
    <name>A0A8J5K0L5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0L5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="113" mass="12615" checksum="2D74E8DA68C7817F" modified="2022-05-25" version="1">MGPIIILCYSLQSDNQFIGYPDTLRFMMGDGIPTLPNTALFSSTILCPDAAVTRSTLYYTSVLCLYPVAMTSVNTHAPFFVTIRTQIDAFDNWNTLVNDYSGFDFDWTANNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1F0</accession>
    <name>A0A8J5K1F0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Zona pellucida-like domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G005556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022531">
        <property type="protein sequence ID" value="KAG7166451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1F0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF54">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7166451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="257" mass="28188" checksum="8C79E53D2EF6FEAF" modified="2022-05-25" version="1">MPGCYMRIFSGSPTDKSVAENVRIGDPLTMVISLDDQEIYGMKVTDCLVRDGLGWGEQMLINKDGCPVDYEILGALEYSSSKTTAAVRFQAHKFPYTSSVYYQCNVKLCIKNAGGCDDVPPVCVEGVNLIRRRRRDVAEVDGNGDLKEVAAEVDENLTIEVFTGLYVNEDEELPEPEGASETLTPVKEEVVEDPNTFCLSPKTFAIGIAIAGLILMIAVIASILILISRRRRRKEDSTTGSSIYSSPYTNTAYSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1Q3</accession>
    <name>A0A8J5K1Q3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G002509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1Q3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="57169" checksum="BFBF3FE472E015DA" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1S1</accession>
    <name>A0A8J5K1S1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative receptor accessory protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G018412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7167982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1S1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="198" mass="22634" checksum="38F483170AD7E9CA" modified="2022-05-25" version="1">MEDEVITQEKIPENTQNSLQEEEVMKEWLSSAADGPVNLTLRERWSSNVIRIKSQVINIRSKVTTMRRSFEGVANDDRYAMARLTGEGSGGLSEASWYCGEVCVCLTSFLLLPFKMAANLEYYKEQAVKILYQKNKLTDFLTKLESKTQVKREYIALAVITYLAFGISVPEPQVLYTTTKANLREAKWTPRILLLCLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2F5</accession>
    <name>A0A8J5K2F5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2F5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="117" mass="13287" checksum="28F421EA435EDE8F" modified="2022-05-25" version="1">MIGKNVTQHSFKRKEQVIPLSSKNAVKIKDDDIIIDQRLLLQRFVTVGSQNDNLAEELEYELCSYPPVLFENRITLRLSMKSALVDALWKLMPPDMLTPSSDIQYALDSGALLHTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3I3</accession>
    <name>A0A8J5K3I3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Mediator of RNA polymerase II transcription subunit 26-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MED26-L2</name>
        <name evidence="3" type="ORF">Hamer_G025287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017710">
        <property type="protein sequence ID" value="KAG7169245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3I3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035171513" evidence="2">
        <location>
            <begin position="17"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7169245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="398" mass="45268" checksum="E8B3B241B6F35278" modified="2022-05-25" version="1">MLQVVIVLLSVSLVLAVASAQLEEKKPVEAKVEAMVEAKAETKAETKVEAKVQASEDEDLVGEESQVVVATQKPAESRQVESRVTEGQLSSGPDDADISFHLDSRGGVATFQGALPREELLETHDQLTAAFDNAADEARQAHTATGVETSVYSYTPYHWAYEVRAPSTGDHKSQVEHREVDGVVRGSEQQQRYNNNEQQQRYNNNEQQQYKNQQERRYVAQNQQFNSQQQQHAGAQLFNARQQQQRQQYTTQQQQEQVGGVQRTQYNIQQQQQPLTNQQLQQLHFGNQQQVSSQQQTQYSTPQQQQLKAREQQQQYSRRQQAQYGIQQQQERQEQQQITGRLGTTSFSSNTQANQLQPGSVVVTPLTNTQYQASQDQLRNQAEYAVLPIVLRRVRKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3J1</accession>
    <name>A0A8J5K3J1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">triacylglycerol lipase</fullName>
            <ecNumber evidence="1">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Pnpla2-L2</name>
        <name evidence="6" type="ORF">Hamer_G010446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3J1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000003">
        <property type="entry name" value="Patatin-like phospholipase domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF41">
        <property type="entry name" value="BRUMMER, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="92"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7166784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="729" mass="81106" checksum="2652782FCD815D66" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3P1</accession>
    <name>A0A8J5K3P1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Inosine-5'-monophosphate dehydrogenase 1b-like 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G005574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022531">
        <property type="protein sequence ID" value="KAG7166465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3P1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF10">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="162"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="413" mass="46970" checksum="918F645AB3FE0D31" modified="2022-05-25" version="1" fragment="single">NQDEEYIRWECANRASLSCKGAISTDHDISVPLSVKEHSHDPDAVHVAVVKLRHQIKDDSRTKKAKTTQIFADAMFEATDEVRARAGKPDTICRDIRRVRRGCRPKEPSSLAELHLDEEWTETGGNNPRPFLIHDSGADTNDRVIIFATEASLRLLSRSSQWHMDGTFAMSPKIFKQVYVIRVLLGETSVSCVYALLLGKTQSIYEELLQAVITQCEHLGCYPDPSTIITDFEQATIKAVSSVSGEHTTVQGCFYHLTQSTWRKIQDLGLVPLYKSNENELVDYFDATYVSGTFRRVQAPPANPNNPLPPVRLRHRPPVFPPAVWNVFESTITRGDRTNNICEDWNNSFRSLIGHQHPSIWTVIEAFRKDQALAAITMLQDQIGERPQKRVRRAQKTYEERLVNLCSDRQFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K448</accession>
    <name>A0A8J5K448_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025267">
        <property type="protein sequence ID" value="KAG7164544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K448"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="70" mass="7887" checksum="AEC62026628DA9D2" modified="2022-05-25" version="1">MITVVVNKLQLMCEFRELAKAMEASIHRPGTPKARRGSEKIKFRDFPSGSEPDERKTAGEAEEASCYHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7C5</accession>
    <name>A0A8J5K7C5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable ATP-dependent RNA helicase DDX52</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Ddx52-L</name>
        <name evidence="15" type="ORF">Hamer_G025553</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010021218">
        <property type="protein sequence ID" value="KAG7167893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7C5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="170"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="379"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="24"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="546"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7167893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="604" mass="68855" checksum="312EE7D23B52254E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K816</accession>
    <name>A0A8J5K816_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeotic protein ultrabithorax-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Ubx-L</name>
        <name evidence="11" type="ORF">Hamer_G005657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="11">Heart &amp; testis</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Antp homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022531">
        <property type="protein sequence ID" value="KAG7166539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K816"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000193">
        <property type="entry name" value="Ultrabithorax, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF21">
        <property type="entry name" value="HOMEOTIC PROTEIN ULTRABITHORAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7166539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="155" mass="17530" checksum="EEC2478ECD02043D" modified="2022-05-25" version="1">MVGGQWKGDIYLAYGADDNDDKSNGNGDDDDDDGDDDEGANGLRRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKKEIQAIKELNEQEKQAQSAKMAQQNAANNAQSMTSSQGAGGGPGGEQNPPNPTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8J1</accession>
    <name>A0A8J5K8J1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G029318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="92" mass="10758" checksum="E01536F5122229CE" modified="2022-05-25" version="1" fragment="single">MAPPAKRTKYETLPITVQQQRGIMELWPEIEEHLNEWIREHLQNGITIARNNIRMESIKWARANPDPRGLTSILHPLDVSINKPFKENVHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KC67</accession>
    <name>A0A8J5KC67_HOMAM</name>
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        <submittedName>
            <fullName evidence="3">Ficolin-2-like 2</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">Fcn2-L2</name>
        <name evidence="3" type="ORF">Hamer_G013827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7171357.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
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        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
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        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
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        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
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        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="48"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
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            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KDA5</accession>
    <name>A0A8J5KDA5_HOMAM</name>
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        <submittedName>
            <fullName evidence="4">Titin-like 10</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">Hamer_G023580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
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            <taxon>Malacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016606">
        <property type="protein sequence ID" value="KAG7169435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="353"/>
        </location>
    </feature>
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        <location>
            <begin position="367"/>
            <end position="499"/>
        </location>
    </feature>
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            <end position="193"/>
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        <location>
            <begin position="1311"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7169435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1452" mass="164242" checksum="42BCC418A0B5CF96" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KEB4</accession>
    <name>A0A8J5KEB4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acidic repeat-containing protein-like</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="primary">GCNA-L</name>
        <name evidence="3" type="ORF">Hamer_G016861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7168219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="881"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7168219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1312" mass="147238" checksum="57205454E703AE0D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJF6</accession>
    <name>A0A8J5MJF6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Frequenin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Frq1-L</name>
        <name evidence="9" type="ORF">Hamer_G019511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046868">
        <property type="protein sequence ID" value="KAG7153455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJF6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008048">
        <property type="term" value="F:calcium sensitive guanylate cyclase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000083">
        <property type="entry name" value="guanylyl cyclase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF198">
        <property type="entry name" value="NEURONAL CALCIUM SENSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="276"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="323"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7153455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="413" mass="45526" checksum="2FF758A042C4D442" modified="2022-05-25" version="1">MTPPPLPPPLPPPPLPPPPLLPPPPPPPHHTTPPLPPPPPLPLPPHFHHSTTTTTTTTTTTTTTSTTTLPPPPHHHHHHYHHHHYYHLTTTTTTTTLHTPPPLPPPPTTTTTTTTTSTTTTTTTTTTTTTPPPLPPPPPPPPPPPPPPPPLPPPLPHHLHTTTTTTTTTTTTTTTTTTTTSTTTHYHHHHHHYHHPPLPPPPPPPPPPPPPLPPPPPPLPPPPPLPPHHHYSVSFCCFFSHKGFLKDCPNGLLTETDGSIEFEEFIRALSITSRGNVDEKLLWAFRLYDVDNDGFITREEMYSIVDAIYQMVGQAPEAEDENTPQKRVDKIFSQMDKNNDEKLTLDEFKEGSKADPRIGQAPEPDDENAPQKRVDQIFSQMDKNHDEKLTLEEFKEGSKADPRIVEALSLGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLA0</accession>
    <name>A0A8J5MLA0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Metastasis-associated protein MTA1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Mta1-L</name>
        <name evidence="13" type="ORF">Hamer_G023221</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the metastasis-associated protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041254">
        <property type="protein sequence ID" value="KAG7155541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLA0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11661">
        <property type="entry name" value="SANT_MTA3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000012">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.50:FF:000001">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035170">
        <property type="entry name" value="MTA1_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF29">
        <property type="entry name" value="METASTASIS ASSOCIATED 1-LIKE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17226">
        <property type="entry name" value="MTA_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ELM2" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="12">
        <location>
            <begin position="68"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7155541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="423" mass="47545" checksum="0A2E738957190AEA" modified="2022-05-25" version="1">MSRSVGTFARALDCSSSVKQPSLHMSAAAASRDVTLFHAMDTLHKHNYDISKALCSLIPATGPVLCRDEMEEWSASEANLFEEALEKYGKDFNDIRQDFLPWKTLKNIIEYYYMWKTTDRYVQQKRVKAVEAESKLKQVYIPNYNKPNPAALSNGKTPSMVNGADISVSGKACESCHATNSSQWYAWGPSHLQCRLCNSCWQYWKKFGGLKLPSRIGKEEERLHSGGSRSQRCNVGGCGREYKTRSQLIRHAAQAHGVALRAGSPRPIMKTRAAIMVHTSLPIRVMRRLCEDLIQPRKACRNPTWPVNATNIRQESLLRMGGKSFDDFAYLVKRGTGRRRGRVSQVSVRLGQKNSSCPAWMLPTDKSLLPKQPHIAFPKPPKGPDGSLIYTPVPNKELPVVNNTSPTLLKRRAYEETNGMDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLF2</accession>
    <name>A0A8J5MLF2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041254">
        <property type="protein sequence ID" value="KAG7155542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLF2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="97" mass="11560" checksum="FF41AE4CE108AC39" modified="2022-05-25" version="1">MAEEQCLLKRCRSSRFIKEGKHIMCDKMSNKKSKFLSKDHAVCRNMMRKVDCCPSWSMNPKYHHSKFKVKNNNNFIQHPHYFLFRLFCVHMVAACSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MM99</accession>
    <name>A0A8J5MM99_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MM99"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="79" mass="8726" checksum="262268115976F3CF" modified="2022-05-25" version="1">MTQNNRQDSLRGPHDTEQQAGLTKGPHDTEQQAGLTGVLMTQNNRQDSLRVLMTQNNRQDSLRGPHDTEQQAGLTKGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMN1</accession>
    <name>A0A8J5MMN1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZBED8-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Zbed8-L4</name>
        <name evidence="2" type="ORF">Hamer_G009961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMN1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF22">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="193" mass="22035" checksum="5D7E87FD68F16BB4" modified="2022-05-25" version="1">MPSSDDNPPPVCGERPDFSKRHERSLGKQRLDESGAFQQQNLSEVEASYEVSIEIAKKKKAHTIGMVKRVLGEASERKIQQISLSDDTVKRRIREMSDDIMEQVIQENKSSPSEFEEEEGKLVRNPFSGTPDIAAIPDDGQDEFLDLRNDSVARDLYEEKSLTVFWCSMYQSYPKVSEIVLRVLLPFSSPFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MND0</accession>
    <name>A0A8J5MND0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ras-related protein Rab-43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Rab43-L</name>
        <name evidence="15" type="ORF">Hamer_G025842</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Endomembrane system</location>
            <topology evidence="13">Lipid-anchor</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">trans-Golgi network membrane</location>
            <topology evidence="12">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036768">
        <property type="protein sequence ID" value="KAG7157806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MND0"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000803">
        <property type="entry name" value="Ras-related protein Rab-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7157806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="233" mass="26622" checksum="0CC8D42B4CA41AFC" modified="2022-05-25" version="1">MSSPQPFATNNAADDQFDFLFKIVVIGDCGVGKTCVVQRFKSGMYIERHGNTIGVDFSMKTLTIDAKKVKLQIWDTAGQERFRTITQSYYRSANGVIIVYDITKRSSFLSIQRWMDEVRRYTHPQVAIVLIGNKCDMETLREVEFEEAEAMCETVPEIMTVMEVSAKDNTNVDDTFFHLASELKNRHDSLRDLIRPYLINLGNTESLKRWPRCSLPAHNDASARLLLAVDGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNN4</accession>
    <name>A0A8J5MNN4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative CENP-B N-terminal DNA-binding domain-containing transposase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G008753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNN4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="74"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="138" mass="15406" checksum="6DC1353450485626" modified="2022-05-25" version="1">MGRNKLTLHEKARALTQLELGMSVIRVASDLKVSRQAIYNLKHAAAPLPPGAIPKRKVGSGAVRKTSIRTDNILKREVMSDPAVTASTLKKKYPDLLKHVAMRTVQHHLQKDLGLPTRRAAKKPLLTEAMKKRRINFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQG7</accession>
    <name>A0A8J5MQG7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G022276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032867">
        <property type="protein sequence ID" value="KAG7159682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQG7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035171538" evidence="2">
        <location>
            <begin position="22"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="414" mass="45196" checksum="D1CF8DEC69AD150B" modified="2022-05-25" version="1" fragment="single">MRATTWLVVLSVLAFYGSITANSERQAKDKGKEAEREVNGGKACKAAGGKCVSSITACYSPLPNHDDCPSSTRKCCGRTVGGSQKSTKQLGKKGKAKKERPDTDGGDKEKNNKKKRRKMDKKKRRKIDKKKRRKIDKKNHREGNDIEKKVKETSKSKQTASIKNSGQRSKDKGKMYGEKPSRKCKQKKKCKKAGGSCKGSCSKRETEMVKGCKGKRCKCCVPEGRECKIKKKCKKRGGTCKTNECSDGEREINKGCGGKGCWCCVPPKQGCQSKKKCTQNNGVCQTSQCSYGEREIPRGCRGPNCWCCAPPEDQCTALSSCDQGHAVCRSSCQNEEREVPGGCHGSSCKCCTRRPPTCPATADCPGICVEKQNCIKPLTYYYCSGYDCTCCQEDGVVTPGTTATTITPTGPTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR04</accession>
    <name>A0A8J5MR04_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030962">
        <property type="protein sequence ID" value="KAG7160718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR04"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="75" mass="8083" checksum="927FBEA2B1AEF1F7" modified="2022-05-25" version="1">MKAHYTYLVPCCPRISAVATPHPNGGRRLVALVLQQDPQKGGAYSTLSAKLTGPTHTPLRGPFVACPNDSSRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRG8</accession>
    <name>A0A8J5MRG8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRG8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="201" mass="22025" checksum="9F8F863FE5A2E870" modified="2022-05-25" version="1">MAIMNGQVTIVLLQWRYLYGFKRGAPSLCELWLLPEPRPRMAATERCNEASMADTVGGPLSPPGPRSLNGPGEARVASFRGAGGAVPGGGEHTLIERRLAKDRLDLLLIGIRSVLYEARCSSHKDRWRESLRLRSVVYTKRSNRNCSAGDILILLDESAGVGTDPQMSDVAKIGVSPVAHVSLLEIPQIVVTYHKEWLIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRL8</accession>
    <name>A0A8J5MRL8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium/glucose cotransporter 1-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Slc5A1-L3</name>
        <name evidence="8" type="ORF">Hamer_G028867</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030653">
        <property type="protein sequence ID" value="KAG7160807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRL8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005412">
        <property type="term" value="F:D-glucose:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819:SF195">
        <property type="entry name" value="SODIUM_GLUCOSE COTRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7160807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="561" mass="62257" checksum="5AA728E465BAAA88" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRW4</accession>
    <name>A0A8J5MRW4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Ace2-L</name>
        <name evidence="17" type="ORF">Hamer_G016213</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 13 14">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRW4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF24">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3 10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6 14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 16" id="KW-0732">Signal</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035158190" description="Angiotensin-converting enzyme" evidence="16">
        <location>
            <begin position="20"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="542"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 1" evidence="5">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 2" evidence="7">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 1" evidence="5">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 2" evidence="7">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="11">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; partial" evidence="6">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10 13">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-10"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-11"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7161167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="582" mass="68291" checksum="2419CB111D06F7A0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MS15</accession>
    <name>A0A8J5MS15_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Extra-macrochaetae-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">emc-L2</name>
        <name evidence="8" type="ORF">Hamer_G022848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029263">
        <property type="protein sequence ID" value="KAG7161479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MS15"/>
    <dbReference type="OrthoDB" id="6371478at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19695">
        <property type="entry name" value="bHLH_dnHLH_EMC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026052">
        <property type="entry name" value="DNA-bd_prot-inh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11723">
        <property type="entry name" value="DNA-BINDING PROTEIN INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11723:SF17">
        <property type="entry name" value="PROTEIN EXTRA-MACROCHAETAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7161479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="162" mass="18157" checksum="0BAD1434BF708490" modified="2022-05-25" version="1">MKSINWDKSAVPVRTSTVAVRSPRGQPEVRQERQEIREYLEKLRQLVPACPKAGKVSRLAVIQHVIDYIVELQDTLVHHPVNTILAANHLTALHDNPLLPLQHLDDNTNKTSFPATSTPTETSISKNNSNTNKNSRTSTNKKTSSCRRPLGVLSSLKNHRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSN5</accession>
    <name>A0A8J5MSN5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSN5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="354" mass="39885" checksum="983BF5F5FFF3AA05" modified="2022-05-25" version="1">MRFEEDKLFLQQQRKPGRPGCMGSVDCNLAKKETRMADRLLQAIKRQLVQEEKTKMWKERIDLVSSSSSSAEISEDEKSPGPSTLPASPSKRPRKLVVNQHPSIGQVSDRNSMYILATTARNMGQEVSYLTISRSSIRHHQIQHRENIAAIIKEKFFLMASLVIHRDGKIMTDIIGRDVVDRLPILVSGGNATQLLGIPKLLSGTGKSVADIVNKAIEEWSEQKMEKELLHLACRHHILEIVLEAAFTAVMGISTGPDILMLKRFQQKWGLIDKSISSTISAMTLKKFQGHLWYLSEHLVPLAIFDDSRSITLEDKMAMAQRLLRTTDEMDPMKRAVVDESAIQEKKISSLFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTH0</accession>
    <name>A0A8J5MTH0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative AIG1 family-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G004453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTH0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="229"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7163328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1059" mass="117775" checksum="96663E65D618DFAF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU66</accession>
    <name>A0A8J5MU66_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G002983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU66"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="19" mass="2278" checksum="6602D2AC2C65075E" modified="2022-05-25" version="1">MALLKQQSIAQLDRPMRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUV1</accession>
    <name>A0A8J5MUV1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">U-scoloptoxin(01)-Cw1a-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G003674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7164466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035261381" evidence="2">
        <location>
            <begin position="30"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="44"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="611"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="730"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
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        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7164466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1640" mass="176913" checksum="0C24339A3E2D5E73" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVE6</accession>
    <name>A0A8J5MVE6_HOMAM</name>
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        <submittedName>
            <fullName evidence="8">Thiamine pyrophosphokinase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TPK1-L</name>
        <name evidence="8" type="ORF">Hamer_G019649</name>
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    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024921">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
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        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035316569" evidence="6">
        <location>
            <begin position="23"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="7">
        <location>
            <begin position="435"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7164812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="574" mass="62645" checksum="9665277FF5785DDE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVR6</accession>
    <name>A0A8J5MVR6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Znf12-L</name>
        <name evidence="9" type="ORF">Hamer_G007275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVR6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7165441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="170" mass="18589" checksum="7E64D9FBE0E69981" modified="2022-05-25" version="1">MSSSEENLVTGRRKGNCYFGAHCHILVLIENAIACGKYCTVPVVWINSKVRSGVASGRVCVVQDATVTPTSCLLQSGQGVVACGWQQLGEGGPWVGGRQGWVVPGRPTGAGERRFVCDVCGRSYKRRDNLSQHQRSHTGERPYVCPRCGSTFSQRWALHYHRLKGCVTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYI2</accession>
    <name>A0A8J5MYI2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Tigger transposable element-derived protein 1-like 312</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TIGD1-L312</name>
        <name evidence="1" type="ORF">Hamer_G018479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7168037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYI2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="129" mass="14694" checksum="217C4EDD135731A4" modified="2022-05-25" version="1">MREVKDCLQEKGLEFKVLLVIDNCPGHPEALEVDNKNVKAKYVTHTFSRMRQALDDDTRDGAESVQKMWKRALWPEVVNDFADFPTVDQDVQYIVQLACQVGGEGFDDLQEEEELLGHAGEELAEVIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZS3</accession>
    <name>A0A8J5MZS3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP-dependent RNA helicase eIF4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Eif4a2-L2</name>
        <name evidence="18" type="ORF">Hamer_G024823</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010016515">
        <property type="protein sequence ID" value="KAG7169446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZS3"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 18" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="83"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="280"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7169446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="423" mass="47989" checksum="2DB7D475BB7AB189" modified="2022-05-25" version="1">MMLDTYEQQGEEDLEAEGKNGDTKPGQQDFHDPAGMDVEGVIETKWTEVATSFDDMNLKEPLLRSIYAYGFEKPSAIQQRAILPCIKGYHVIVAQAQSGTGKTATFSISILERIDPKSKETQALILTPIREQAQQIQEEVLALGDYMNITCHACIGGTNLREDMRYLEKGVQIIVGTLGRVYDMLKRRVINPGKIKMFVLDEADEMLSRGFKDKTYDVFRYLPNDVQVVLLSATMSPDVMDVTSKFMRDPVTILVEGKELTLEGIKQFFVSVTKRNKLKTLNDLYKTLIISQAVIFCNTCRMVDWLMAQMQHRNPRVSAMHGGMNQKERGAILSKFRSGSARVLITTDLFARLPDIDVSLVINYDFPSNRESYIHRIDPGGRFHRKGVVINFVTADDTRALMNIEKYYRTSIEKMPSNVEDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0J2</accession>
    <name>A0A8J5N0J2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomally synthesized cyclic peptide ustiloxin B precursosr-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ustA-L</name>
        <name evidence="3" type="ORF">Hamer_G023991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013974">
        <property type="protein sequence ID" value="KAG7170524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0J2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="308" mass="32692" checksum="3E53DA2D08213CAB" modified="2022-05-25" version="1">MWVQYSSRLNTLTSTTLSPYSPSPSAVFTTVVAAVMRVLVLVLLVEVVALASAGQWFLSQPQRRDLTLMLPPAQLTGTSSFYFEDSKENSPEDLSAISDGVDVADTNSVEDVDNSLSDTNSVEDVDNSLSDTNSIENVDNSLSVADTNSVEDVDNSLSVSDTNSVEDVDNSLSVSDTNSVEDFDNSLSVSDANSVEDFDNSLSVSDTNSVEDVDNSLSVSDANSVEDFDNSLSVADTNSVEDVDNSLSVSDTNSVEDFDNSLADANETDDNVSPNDAVSDALDDADDDKSSPDDVSDDVDGNTDEVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N114</accession>
    <name>A0A8J5N114_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012436">
        <property type="protein sequence ID" value="KAG7171365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N114"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="308" mass="33967" checksum="223FE748D2175A15" modified="2022-05-25" version="1" fragment="single">WVSLLCYVAEVGEEWREGVRLDQGCASSVKEVLTDNRAIRVFSDTSSPRKYSRVCSNAFERINSAKCQPAYGKPLACYAHNDYGSRRECSQRAAWSLCPVELSHHGKENQCERAISCFSARNLVFPLRGGDGSGRGLVQRRKEVGWFRRRPLPYTASRRWGDTSSRYGLTGVGVIPHMMNVNMTLDTQDLALGRRAAALRASLPAACQAMFPHEGQIEVACNVDLLPAHLASVGCHTMRLSLGGQYMYARTDVIEGRVLKEAGGVGVVGRLIGFTPRKRALAIHAPHGQAEAWRNARERGCSMNSRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N314</accession>
    <name>A0A8J5N314_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G009604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N314"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="80" mass="9039" checksum="5DFDA838966B1681" modified="2022-05-25" version="1" fragment="single">MSSADNSGSKKPQSARKIRELCSKLKVKDWRGGARIRIFKLQRKTGDTEQSAAEDAGDEEEPQRTLTTKRMAEAFKNIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N395</accession>
    <name>A0A8J5N395_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Jerky protein-like 78</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">jrk-L78</name>
        <name evidence="2" type="ORF">Hamer_G025636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011252">
        <property type="protein sequence ID" value="KAG7172416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N395"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="212" mass="24055" checksum="ED60D3FB559A904D" modified="2022-05-25" version="1">MFTSHSNEDTENDFAGFRVSKEKQLIHELLAYVKDVTNPDAKELSSRINEDVLTEWLDVDDNVPTVHHYTDSEIVDMVKSPERNACTGSDEDESSEENEEDVRDRISIDRLITLTTELLAGLEQRSFVSEQEIMNVFLLQDKLIKERPKYMKQQTLPDIFKKIVRKQEEATAVSTLDNPLPSTSRQVEAVPVAEDVVTVSDKDDNPDSPSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4D3</accession>
    <name>A0A8J5N4D3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4D3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="76" mass="8844" checksum="0598022DDF110B32" modified="2022-05-25" version="1">MHENESSSSSEGDDKDHDVEDELFQALYETPPGMKKTVTFSSVSWERNRRKKIRQEHLPQQGHEGVVHQIQHPHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8B0</accession>
    <name>A0A8J5N8B0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fasciclin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Fas1-L</name>
        <name evidence="1" type="ORF">Hamer_G018097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007025">
        <property type="protein sequence ID" value="KAG7174778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8B0"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="94" mass="10896" checksum="7173E486A5D30FD1" modified="2022-05-25" version="1">MIHRKLPSAYKKLFMGTFAYHVKYILERHMIVGQDLSLEELTALTNNATKRGQYFEERLEMTRGKIYFQARVNYRLNGTDFIDTGDTEGEGGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8V1</accession>
    <name>A0A8J5N8V1_HOMAM</name>
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        <submittedName>
            <fullName evidence="3">Filamentous hemagglutinin-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fhaB-L4</name>
        <name evidence="3" type="ORF">Hamer_G015137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF37">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 13, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="35"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="123"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="258"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="323"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="694"/>
        </location>
    </feature>
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        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
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            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
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        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
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            <end position="484"/>
        </location>
    </feature>
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            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
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            <begin position="575"/>
            <end position="621"/>
        </location>
    </feature>
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        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
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        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
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        <location>
            <begin position="653"/>
            <end position="669"/>
        </location>
    </feature>
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        <location>
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            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7174938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="759" mass="81095" checksum="DAE32D3AC0E1E88C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8Y5</accession>
    <name>A0A8J5N8Y5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Immunoglobulin domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G015246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7175033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:neuron projection membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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            <end position="182"/>
        </location>
    </feature>
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            <end position="21"/>
        </location>
    </feature>
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            <end position="410"/>
        </location>
    </feature>
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    </feature>
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            <end position="380"/>
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    </feature>
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            <end position="404"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7175033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="410" mass="44371" checksum="CF5BB3FDDB3A0CEA" modified="2022-05-25" version="1" fragment="single">MDVNPATLPPPLPPQLDPSHSTDVTALADKTAILNCRVHNIANKTVSWIRHRDIHLLTVGRYTYTSDQRFRALHEDDSDDWVLKINYVQPHTHILGGPDMYINKGSTINLTCVVEFSPEPPDFIYWNHNNKIISYDSTRGGVTVIIEKGDVTTSSLLIQKAQPSDSGRYDCNPSNASPANVTVHVLNVKRRTPGSDATWRTRDLHFLLPQEYSLPLGCSSGTPHPSAVVATKPSAVVATKPSAVVATKPAGVATKPSAVVVTKPSAVVATKPSAVVATKPSAVVATKPSAVVATKPSAVVATKPSAVVVTQTFCSSGHKTFCSSGHKIFCSSVGTRQVATPSAVVDLKTILCSNASTHTHTHTQTHTEKKKDEGEKGKEEKKKKKKKEAKKNKNKRSKKNKNKKKDIEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N996</accession>
    <name>A0A8J5N996_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neuronal pentraxin-2-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Nptx2-L7</name>
        <name evidence="9" type="ORF">Hamer_G009124</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N996"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051360">
        <property type="entry name" value="Neuronal_Pentraxin_Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277:SF125">
        <property type="entry name" value="B6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277">
        <property type="entry name" value="PENTRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pentraxin (PTX)" evidence="8">
        <location>
            <begin position="196"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7176331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="353" mass="40599" checksum="F6208895782CD7D2" modified="2022-05-25" version="1">MNRSGTTVTTSDVKRKIESLRNQHRRELRKMQKSKKSGAGTEDIYIPTLWCFDALHFLIDGDRIRQSVSNMDTHTTEDMSEVHSDHKIFNDQLLLGLDDNYIIHQPLSLVRPRPPSLVWLRRLSLVRLQNRILVNPHPHHHAEKQLMLWLNGQGQTDDLDINVWDVALETWNHLCHILSRTTYTIYWQGEELFTGNLEAGWSLEMNGSLVLGQEQDSLGGGFDVTQVMIGEIAQVSIWDRAFWHTEVVDMAACHTLGRGNIFNSDTDELEVYGVTFKFVDVESFCRSPNHYYMILPEEQTLSESNDQCQMLKAPLAVPNDATDNDHLTEELLPYEQLCSPGKDWKQWLGISDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA73</accession>
    <name>A0A8J5NA73_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 1A-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Arpc1a-L3</name>
        <name evidence="6" type="ORF">Hamer_G026803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005100">
        <property type="protein sequence ID" value="KAG7175628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA73"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7175628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="104" mass="11452" checksum="9978188A45419FCB" modified="2022-05-25" version="1" fragment="single">MSCESALERIWGGRDAMALFTSRGPVAEVFRFGLVPIACRARNEDRSQVALSLNNNEVNIYGRAASEWKLQETLQGHDLRVTGIDWAPSTNRIVTCGAVSLLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAD5</accession>
    <name>A0A8J5NAD5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G020786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004696">
        <property type="protein sequence ID" value="KAG7175718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAD5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="70" mass="7878" checksum="27297FDEC4ECE49D" modified="2022-05-25" version="1">MITRVGHPTWFSRNHILSRNQLLGRLLDMSYGMAALMSGRNSPGRFGYHWLMALGTTIDLETTQHTGATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAF5</accession>
    <name>A0A8J5NAF5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SHMT2-L</name>
        <name evidence="11" type="ORF">Hamer_G016996</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7176032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAF5"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000050">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="12"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7176032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="439" mass="48820" checksum="56D63555AD050CE8" modified="2022-05-25" version="1">MAEDDPEMWQLNFCTRSGLEALGSCLNNKYSEGYPGQRYYGGTDIIDKVERLCQQRALDAFRLKPEDWGTNVQPYSGSPANFAVYTGLLNPHDRIMGLDLPEGGHLTHGFMTDNKRISATSIYFESMSYKLNPATGQIDYDKLHEHARLFRPRMIIAGASAYARLIDYKRMREIADEVKAILLADMAHISGLVAADLIPSPFEYCHVVTTTTHKTLRGPRSGIIFFRRGVKSVNKKTGKPIMYDLEQRINSALFPGLQGGPHNHAIAGVAIALRQAATPEFKKYQEQVMSNCRTMADGLIKRDYHLVSGGTDNHLVLVDLRPKGLDGARVETICNMCNITVNKNSVPGDKSALSPGGLRLGTPALTSRNFKNEEFEYVVELLDRACAIALEAKEKSGKKLADFKETLEKDAEIKAKVEALQAEVNEFSLKFPMPGFDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NB78</accession>
    <name>A0A8J5NB78_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Splicing factor 3A subunit 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Sf3a3-L</name>
        <name evidence="10" type="ORF">Hamer_G009223</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NB78"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025086">
        <property type="entry name" value="SDE2/SF3A3_SAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13297">
        <property type="entry name" value="SDE2_2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="318"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="252"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7176412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="413" mass="47659" checksum="0E08018FD19DBB4D" modified="2022-05-25" version="1" fragment="single">NREVINSDHRHRILLDRYVEASQHLADLYEDKDGLRKEEVAALSGPNELAEFYNRVPMSVEFEEINKQREANDENLVMVDFTDEEGYEKKTTQYREYLHVLLDYLYIYVERVKPLLDLGEELDCVNKDFTEQWDGGRFPGWPKETGGALAAMGAHLDLSAFSSSEELMSLGLDRLKSALMALGLKCGGTLEERAQRLFKTKGMSVEELDPSLFAKSKPGKVTKGRETEKIRELAMLEAQVYRLTETLSEQRMATKENVQRKQARRDGEEEEEEEASASESEDEADDEVPYNPKNLPLGWDGKPIPYWLYKLHGLNISYNCEICGNFTYKGPKAFQRHFAEWRHAHGMRCLGIPNTAHFANVTQIEDALKLWEKLKVQKTSERWQSEQEEEYEDSQGNVVNRKTFDDLKRQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBB6</accession>
    <name>A0A8J5NBB6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G009201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBB6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF850">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="66"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7176394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="229" mass="25959" checksum="DBD6BD1FF1FC1FEE" modified="2022-05-25" version="1">METNDVLWESKSAEGGNEDAHIWKPLELKPPGQEGVKVDLALEERDLDVEEGDVEVQPPEELRDARGVTNTIRPWPNAIVPYEIVTSALRNIEDNTCVKFKKRAGEARYLLIKSGSGGCWTSSLGYPSYDKKVTINLGKGCVKPGRIRHEIFHSLGFPHEHARPDRDQYIIIKWNNIKDGASSQFKVDNRFPTLQVPYDVKSIMHYGKFAFTKVIIGALRNLFLDHMMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBQ9</accession>
    <name>A0A8J5NBQ9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative GDNF/GAS1 domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Hamer_G009097</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDNFR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBQ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057681">
        <property type="entry name" value="DUF7921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059035">
        <property type="entry name" value="Fn1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016017">
        <property type="entry name" value="GDNF/GAS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037193">
        <property type="entry name" value="GDNF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003438">
        <property type="entry name" value="GDNF_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269">
        <property type="entry name" value="GDNF RECEPTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269:SF12">
        <property type="entry name" value="GLIAL CELL LINE-DERIVED NEUROTROPHIC FAMILY RECEPTOR-LIKE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25537">
        <property type="entry name" value="DUF7921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25868">
        <property type="entry name" value="Fn1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02351">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00907">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110035">
        <property type="entry name" value="GDNF receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GDNF/GAS1" evidence="9">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="9">
        <location>
            <begin position="198"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="9">
        <location>
            <begin position="271"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7176308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="676" mass="76211" checksum="3AD9D29F9B34C0EE" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NEN4</accession>
    <name>A0A8J5NEN4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DDE superfamily endonuclease domain-containing protein 29</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Putative DDE superfamily endonuclease domain-containing protein 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G028275</name>
        <name evidence="4" type="ORF">Hamer_G029367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020820">
        <property type="protein sequence ID" value="KAG7168081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010001443">
        <property type="protein sequence ID" value="KAG7177879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NEN4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="152"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7168081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7177879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="299" mass="33916" checksum="1C3DAA48798FDCF1" modified="2022-05-25" version="1">MPRRHRITSATDRERIIEAYRSEQDFLVVAAALGVQRTTAYSIVRVYQRENRVEAAHTGGRHKIIDNETLDLIVMLLEASPMMTLREIKEEVMDIFPTKPHFSEVTLSRYLEGELISLKMSRDSPAERNSPAVKEARHAYATWMLATGLQQQLVYIDETGFNLWTKRTYGRARCGERVHRAVGGQRGRNTTVIAAIAEHCGILYHEIHYGSVTKEVFSDFIASLAAILGDARSILVLDNAPIHNGIAAVYPELNFKFLHPYSPCLNPIENCFSVFKSYLKQYLHREAPRCNAAQPGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TCE3</accession>
    <name>A0A8J5TCE3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Collagen alpha-2(IV) chain-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Col4a2-L4</name>
        <name evidence="2" type="ORF">Hamer_G000817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TCE3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="553" mass="59214" checksum="3C3B538CD6C42AC9" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5THH6</accession>
    <name>A0A8J5THH6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5THH6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="76" mass="8603" checksum="5F19F3EAE9C59D43" modified="2022-05-25" version="1">MKRSLKFKRAIDTIYVPNKEILKDLHRKSKQKITYFSTPQSPQPSTSSAKPELYEPQPSSSAHLETEADDPDDPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TK45</accession>
    <name>A0A8J5TK45_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Argonaute 2-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ago2-L12</name>
        <name evidence="2" type="ORF">Hamer_G029117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009402">
        <property type="protein sequence ID" value="KAG7173567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TK45"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="1">
        <location>
            <begin position="77"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="163" mass="19107" checksum="876F58C532B79702" modified="2022-05-25" version="1" fragment="single">MDMVEVMFRHYRAIKYELVGRRNFYSAGGEFGTPYPIGCGKEGVTGFFGSMRPASWKDGSLLLNIDVAHTAFYKEQPLLNFIQDFMNFREDDFHRPLEPFKRSKLLQELRNIRVQVTHSNIPRTYKIIDVSEHSAEKQTFPLKDENTGNTVYCTIENYFKNQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TN86</accession>
    <name>A0A8J5TN86_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydroorotate dehydrogenase (Quinone)-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Dhod-L1</name>
        <name evidence="3" type="ORF">Hamer_G020780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004696">
        <property type="protein sequence ID" value="KAG7175712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TN86"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="108" mass="11907" checksum="DADBCC68A195C182" modified="2022-05-25" version="1">MMGLTSRLFTNKVFKKKITDIFKVAVGGGVVFAGINVYFKNEKFYDTWIMPVFSLLDPETSHTLAVTAAKYNLVSEVKLRESKLLDPPGQSSSLSTPMGITAQESVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J3X1</accession>
    <name>A0A8J5J3X1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crustacyanin-A1 subunit-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Cra1-L2</name>
        <name evidence="4" type="ORF">Hamer_G009354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J3X1"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF62">
        <property type="entry name" value="LIPOCALIN_CYTOSOLIC FATTY-ACID BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045015475" evidence="2">
        <location>
            <begin position="26"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="3">
        <location>
            <begin position="57"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7153687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="199" mass="21773" checksum="F74391BACB0F4CAF" modified="2022-05-25" version="1">MSTPFVFSGQVMVAILALTWTVAQSQSITGNSTGLLVKGLCPIVKLAKNFNTTSFAGSWYRVGGLPNYEERSVNCTIYNYVDTGSGFFVESTGVARNGDPTIQNKTLVTVTPGIARYSTHVRDIEAEMVVLGTDFVTYACLFTCYNFQGTHKVMFAWIFSRKSTLSRANIALCQKHFVAVGVPINNLRGTYQGPKCGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J933</accession>
    <name>A0A8J5J933_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycerol-3-phosphate acyltransferase 3-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Gpat3-L2</name>
        <name evidence="10" type="ORF">Hamer_G010594</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J933"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF2">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 4, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7153299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="130" mass="15191" checksum="9DB6691A2B297214" modified="2022-05-25" version="1">MQFKKGTFEVGGVIYPVAIKYDPRFGDAFWNSSKESMVSYIYMMMTSWAIVCDVWYLPPMTRTEDESSIDFANRVKAEIARQGGLVDLVWDGGLKRSAPKKEWKQQYQQEFSRRLKVQNVNSEKKEEKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J9Z0</accession>
    <name>A0A8J5J9Z0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Vps45-L</name>
        <name evidence="7" type="ORF">Hamer_G014985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J9Z0"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Vacuolar protein sorting-associated protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7154636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="566" mass="63626" checksum="C518FAC28B943743" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JB35</accession>
    <name>A0A8J5JB35_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045715">
        <property type="protein sequence ID" value="KAG7154064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JB35"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="135" mass="15499" checksum="A258C607383E2BA3" modified="2022-05-25" version="1">MYGKPNLTSVNTARHMLFDQHFAPKQKSQPLHKIKGTDPSNLPPCKSVLLEKLKRTNLVASMWKNAITPESYKWAPEENGWLLENGRYVINWFEGQQVPEDVCLHIDDNVGTDMANEEEDETEYCSSSHESQYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JBC4</accession>
    <name>A0A8J5JBC4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase II subunit RPB1-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Polr2a-L7</name>
        <name evidence="2" type="ORF">Hamer_G022545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041296">
        <property type="protein sequence ID" value="KAG7155532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JBC4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="568" mass="61917" checksum="7BD428BE7B195C59" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCX5</accession>
    <name>A0A8J5JCX5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044001">
        <property type="protein sequence ID" value="KAG7154754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCX5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="102" mass="11487" checksum="0D6F36B44838211B" modified="2022-05-25" version="1" fragment="single">GIGLCSCWPPLWAPRIQCARGIKRGVRDLKQQLQVHHQMKLEVKGSLTNSGELRRVIGEMLGTHLQDERTDDEVSDDENKNLTLNNLGEVIRMSKALSARLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JD77</accession>
    <name>A0A8J5JD77_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Glutamate receptor ionotropic, delta-2-like 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Grid2-L27</name>
        <name evidence="14" type="ORF">Hamer_G022608</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041542">
        <property type="protein sequence ID" value="KAG7155461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JD77"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="13">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7155461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="343" mass="37227" checksum="EF85FF5F61340186" modified="2022-05-25" version="1">MRQSSPTLRVVESAGDGGPHLVGFLAEVMAFLQQSLHFRYNVSQVRGYGTRLINGSWIGLVGAVAEKQVEVGLSSLSITYERRQVVSFTSHLLESSVYLMFPAKHILKPIFVVFLIFTPLRSTITLNTNTSTSPSSPSSGNLTAFLSIPRLQQYPSTPEEMLQQGYAPLLTKGFSHYDNFKYSRLDTFQKLFRVAQERGSIYPFGRVDHNTVMDRFSESPVASIISALGVVYRQNSGAGPNQPCAFYVEPEPLSSQLIWLRDMGVLKRASQKHNAIHCLGGGGMGDGVDGGGSVSGGSLPLSLTDLQGAFLLWVAGTVLSLLFLLVEVVVVRCVGGDRSGVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDM9</accession>
    <name>A0A8J5JDM9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">abs-L</name>
        <name evidence="19" type="ORF">Hamer_G017645</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX41 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010046276">
        <property type="protein sequence ID" value="KAG7153835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDM9"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17951">
        <property type="entry name" value="DEADc_DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000449">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000657">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044113">
        <property type="entry name" value="DEADc_DDX41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="205"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="400"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG7153835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="620" mass="69532" checksum="2D2FB4F1723E1FC3" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDZ4</accession>
    <name>A0A8J5JDZ4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Transposable element Tc1 transposase-like 56</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tc1a-L56</name>
        <name evidence="3" type="ORF">Hamer_G022583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040186">
        <property type="protein sequence ID" value="KAG7156045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDZ4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="191" mass="21901" checksum="E6A68BEF9986C95B" modified="2022-05-25" version="1">MGSGKELGRDTIVAIITLYKEGYKCKDIATRVGIGVRQVQKWIKKFRDGGGEDIPTPKPRSGRPRKIQNRTSKVIKRQLDKNPTLTARKLMENNPALLQDVSVRCISDHLLKDLQYRSCCAKVLPLLSAKNVRDRIAFSKKYKDWTVEDWEQVLWSDESTFVVSSGCRSKRPTYKDSVRQSEGRCELNRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGF3</accession>
    <name>A0A8J5JGF3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase D-interacting substrate of 220 kDa B-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G012097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGF3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052771">
        <property type="entry name" value="Neurotrophin_sig_adaptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057092">
        <property type="entry name" value="SAM_KIDINS220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116:SF0">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23307">
        <property type="entry name" value="SAM_KIDINS220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="KAP NTPase" evidence="3">
        <location>
            <begin position="114"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Kinase D-interacting substrate of 220 kDa-like SAM" evidence="4">
        <location>
            <begin position="488"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7155951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="674" mass="75898" checksum="2953234DF22490CA" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGV5</accession>
    <name>A0A8J5JGV5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Platelet-derived growth factor receptor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Pdgfra-L2</name>
        <name evidence="4" type="ORF">Hamer_G020459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PDGFRL, TNK2 and GRB2.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045000">
        <property type="protein sequence ID" value="KAG7154153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGV5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042495">
        <property type="entry name" value="PDGFRL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15360">
        <property type="entry name" value="PLATELET-DERIVED GROWTH FACTOR RECEPTOR LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15360:SF4">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="14"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7154153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="201" mass="23077" checksum="88B12CE7951A1171" modified="2022-05-25" version="1">MGWTQAENEQWVAPEIVGGLSEMLVEDGSNVNFTCRAAYPVTWCTEKNFASEHHQELYEEGQPKPYVAILTIDPVNYLHVGYYTCLYNTTTNRLKKTCDIKDPQISSIYLYVQDLSHLLVSEAYGFFFPLTVNEPFVIPCKPTFPDVEVSLEKIQTNEEYDPREGFKKYFTHEDTDICLAKYLNLTEQAATNLCTKTLTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHV1</accession>
    <name>A0A8J5JHV1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Immunoglobulin domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G010713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHV1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="161" mass="18539" checksum="95BB2101DE2372F9" modified="2022-05-25" version="1">MYTGTGVLSQFVNLHVNTPRAAVLGPQELHVQEGDTITLICVIQQSKPPFVFWYHGENMVNYDGNRHRLNVITKVEGTRTHSRLTITDARRRHGGGDTQSGSHFRGGRQFLRRQVGRHSLPGLRFLLRSLPPRQMIAWLHDALLDIHIYTVYIYRRENNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHZ7</accession>
    <name>A0A8J5JHZ7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G006158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHZ7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="398" mass="45160" checksum="5E600DB47EEDDA31" modified="2022-05-25" version="1">MRTAGKSPVVIEAMDRTNLSDRNAVFVAGAVAQALGHDIADMSFSRSTIRRYRASGRKQAAETDRKSFSPDEPLLLHWDGKLLPDVQNTTASRIAIVVTFNGQEKLLGNVEKLVKGLVFDTTASNTGLHRGACVRIEDELEQELVWIACRHHVLEIMLSDVFSLICGSTGSPETILFKRFKKQWRSISLNDFIPAPESIFWHEAPMAVRAPFNDLQLMKVLKEYPHEKVAHAAQAAISRHLWYLSEHLIGLSLFDDRIDTETKKNMVQNFQCPKKQDFSRRIVLSDETPISNVASFVTERTLDIFDVLTLDGKERAQLFLSKDPKTWKDDEVFITMRDRAINMKVVNDSAERAIALIERYKESITQNEDQKQYLLQVVAAHRKKLPTASKAAMMKGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIC3</accession>
    <name>A0A8J5JIC3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pogo transposable element-like 71</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Pogo-L71</name>
        <name evidence="1" type="ORF">Hamer_G008743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIC3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="84" mass="9571" checksum="9E1FDEBBCE544BD0" modified="2022-05-25" version="1">MRAPELDVLCDFVIKAWNDINVETVIKSFKKCGISNSMDGMEDDMLWEDEDETEAEATSSDLEFDPYDDATINVSQDVLEELMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ29</accession>
    <name>A0A8J5JJ29_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PiggyBac transposable element-derived protein 4-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PGBD4-L5</name>
        <name evidence="3" type="ORF">Hamer_G028878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038134">
        <property type="protein sequence ID" value="KAG7157091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJ29"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="82"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7157091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="242" mass="28325" checksum="1AA7A2F1F7D8F4FE" modified="2022-05-25" version="1">MSSSTEDSEYEPSLRSLNTSDNSASSSDNDYFSTSEEEEEEGEGRAWRSLELSEERMNTPPPRFPFTGNPGIKIDENPAELSPFEFFSLFIDKRIIDSVLVETNRFAEQTGQDDSLWRPVTEAELFVFFAMKMLGGIVKMPEEEMNWSHDELLERPIFRQLMTMKWYSKIKQYLHFVDNETHDAETHPNPKLYKIYDVFMTLCENFGKCYTPRQDVCIDESLMLFKGRLGWVQYIPLKIKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ80</accession>
    <name>A0A8J5JJ80_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G011299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJ80"/>
    <dbReference type="OrthoDB" id="6341896at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="244" mass="27525" checksum="BA620E7A90FB2A6A" modified="2022-05-25" version="1">MLPASDMLPLQDEAVTIEPQYDGVIMLSPEAVLFSDAKPRPDGSKVYHVFERTLGDPPRDEATQSEDFQSRREQLFSQAHENTLHDIQQVLAESGLVNQEWCEASGVGEAADSTSVPTTNAASAYQINDPNFQTPAGQTLTNSNHRTCLTRHQRLTPCRLHQFEMVFPNEQKRRLLKRLRRKGMGYVEFEPENHRINIKTRKSVNTILSVLRGVDPNARHLGTCRDTLIEETVEPDSSEIMDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JK16</accession>
    <name>A0A8J5JK16_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G017419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7159977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JK16"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035224927" evidence="3">
        <location>
            <begin position="22"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7159977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="392" mass="43480" checksum="70518D7C56D9DEE7" modified="2022-05-25" version="1">MRTVLMAMVVAAVNLQHWTMARHSECKVNLTEPLNLHLSSSKVESEKILWGEISVFPGPNNQSWVLNFTFRRADELLASVFVSHMRRNGSLSQLDVIRIVCEGNEPVDMDDPWPDPWLQATPRLIKVLESNVFTHICTGKLNSLHNMSLTVESDPCCPAPTLTVSCDTDNGSPESSSPESGSPESSPPWITWLAVSLVISVMVVVVGGVWILRCKCSRKPVQEMIMMPDSSYEEIGQEGPSQEAETPRFQQRKPMPSPRNVFLQRREMRASETSTSSFISSGTTSTLSTVVFGPATPPPVPNCPSFSVGGSSTSPALPLLPVNSVPQSRTRHSSTGQHHWQPSPLSEPRIPPAAADVTLRRHRTKQKKSEKQKQEEKEEDPVYERVTYLFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JK95</accession>
    <name>A0A8J5JK95_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">O-glucosyltransferase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">POGLUT2-L</name>
        <name evidence="9" type="ORF">Hamer_G006304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Protein O-glucosyltransferase. Catalyzes the reaction that attaches glucose through an O-glycosidic linkage to a conserved serine residue found in the consensus sequence C-X-S-X-[PA]-C in epidermal growth factor-like repeats. Regulates Notch signaling by glucosylating Notch in the ER, glucosylation is required for the correct folding and cleavage of Notch.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JK95"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046527">
        <property type="term" value="F:glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF122">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Filamin" evidence="7">
        <location>
            <begin position="32"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="8">
        <location>
            <begin position="239"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7158926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="515" mass="60444" checksum="5FE80BEDD961F67D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLI8</accession>
    <name>A0A8J5JLI8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLI8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035175798" evidence="1">
        <location>
            <begin position="32"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="124" mass="12955" checksum="7AB0C451C60656E3" modified="2022-05-25" version="1">MTFSCTTTTTTTRFLCLAFIVSFSLCLGVSSSPVPEGQGRFITSESPSDDPSNLLNILTNLNLFSSPANPNPTIVVPPSLEGFASQFVDGSTDCPTGQSCVIAASFQPNTGLVSFFQSLCPTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLK3</accession>
    <name>A0A8J5JLK3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucose-6-phosphate exchanger Slc37A4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Slc37A4-L</name>
        <name evidence="8" type="ORF">Hamer_G017332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7159900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLK3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061513">
        <property type="term" value="F:glucose 6-phosphate:phosphate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051337">
        <property type="entry name" value="OPA_Antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43826">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43826:SF3">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="86"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7159900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="512" mass="54531" checksum="71FDB947E3873023" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLP4</accession>
    <name>A0A8J5JLP4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G006630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLP4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="93" mass="9636" checksum="2EE69976EFD03AC6" modified="2022-05-25" version="1">MCDVLDSAMTGDVLDSAMTGDVLDSAMTGDVLDSAMTGDVLDSAMVYKALKHNSSRYSECWVIMGGGAKVFQLVGASLAPRLGSRIVSAGVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLY7</accession>
    <name>A0A8J5JLY7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G015935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041065">
        <property type="protein sequence ID" value="KAG7155574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLY7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7155574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="150" mass="16051" checksum="18DF84CA066F9BF5" modified="2022-05-25" version="1" fragment="single">VEGLQVAGKYHLVVTAVNAKGASEPVLLTVTSLSTNGSVRDGGKINTSNTKPTDENHHTFLDTLALPSVIMVVLGVGSGLVLLVILLLLFITFRSRRAPQLLSLAAGVHSHKEMDDRHSRAATGRSPRSSRTSSTLTPEHDSSCLEREMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMS5</accession>
    <name>A0A8J5JMS5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum-Golgi intermediate compartment protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ergic3-L</name>
        <name evidence="11" type="ORF">Hamer_G001832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMS5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="10">
        <location>
            <begin position="12"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="9">
        <location>
            <begin position="157"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="9">
        <location>
            <begin position="291"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7160546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="418" mass="46015" checksum="41B6B435010AF3CC" modified="2022-05-25" version="1">MGSTVKSVADKLRQLDAYPKTQEDFQIKTLSGAAVAIVAGIIMALLFLSELYDYLTPKLAEDLFVDTTRGSKLRINLDVIFPNIPCNMLSLDAMDLSGEQHVNIHHNIYKRKLDLDGRPIQDPERQERIGHAVKEDVNGTQENNVVQTTAAPKCGSCYGAESEKDQCCNTCEDVKDAYRTKGWALPPLKNINQCVKEGKLVESSELPDEGCQIYGYLEVNRDDEACGGGDGKGGRCAIFDGLDDTSCYFFLGEGTIARIVGIHLQPLAHILLGNSSVITVMEKSVGLFHFKVGGNFHLAPGKSFQHNHLHIHDVQQYRTADFDLSHRIRHLSFGVNIPGKTNPIDGTELKTEKGPKTINYYIKIVPTTYEKVDGSLGHFLTGVCSIIGGVFTVAGIIDSIIYHSHRALQRKIEIGKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JR09</accession>
    <name>A0A8J5JR09_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epoxide hydrolase 4-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ephx4-L2</name>
        <name evidence="2" type="ORF">Hamer_G019410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027477">
        <property type="protein sequence ID" value="KAG7162687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JR09"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="187" mass="21760" checksum="4A58C75C5226042D" modified="2022-05-25" version="1" fragment="single">VEGYIAGPTPTQAVLLSSHTRQGDSVILTLTVICADSLVHTEMGDVRKYLVFVFVWGMSLATSLMVVPWLLWLRWKVGKEVFSVKPRPTPPPALKDSKWGSLTHTYMDLKTQGVKLHYVEAGDHNNPLMVFLHGFPECWFSWRHQLKYFSENYWYIFLFQMPWLPELLIRTQDLKAFEDMLRGNKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRM2</accession>
    <name>A0A8J5JRM2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oplophorus-luciferin 2-monooxygenase non-catalytic subunit-like 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Lucb-L16</name>
        <name evidence="3" type="ORF">Hamer_G025965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033026">
        <property type="protein sequence ID" value="KAG7159658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRM2"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF398">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035308053" evidence="2">
        <location>
            <begin position="23"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="342" mass="37659" checksum="814C4C049B160F54" modified="2022-05-25" version="1">MEAYQCSVGFFFLVFLCVGSHAWIDPNDDSCPDPSVISPCVCSVVPGNSRHIDCSDVRDEDDLACIFSSSSLPTFKKLTIEYNTRLSVLRAGLLGNASFEEVYIYGGALEEVDRGFLAGSYNTAISIDFSYNWLTDFIFDDMSLFTKLKSLTLDGNKLSYLPPITSPTLASISVGENPFSTLEPSTFQHMPALETISIFKTGLNNILAGTFSGLEHLTWLSLGENLLTHIHSNAIQFTEPGASLYLDRNSIKYIIIDAIGGLTNGALYVYNNKIVELEEDIWRPMLEAGNEIDLRNNPLTCGCDIAWLLHDPTLLSLINHQTICVDGTLLVDINPDDIDAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUF5</accession>
    <name>A0A8J5JUF5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glutamate receptor ionotropic, kainate 4-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Grik4-L4</name>
        <name evidence="13" type="ORF">Hamer_G007817</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUF5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF38">
        <property type="entry name" value="IONOTROPIC RECEPTOR 100A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="12">
        <location>
            <begin position="52"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7162303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="154" mass="17652" checksum="140595CC7DAFFB66" modified="2022-05-25" version="1" fragment="single">TASEGEQVWVYRRCLYCKKGEAQVQLLYQGNVTSGLQHRINLFPEFKEPGTPVAPRDSLNTRMLHTFANNLNFSYVLREPLDEKWGTPAADGNWTGIVGTLQHQQADFSLDLTLTESRSRVMDHSRIYNYDPYIILSLKPSSLPRHLALTRPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUL7</accession>
    <name>A0A8J5JUL7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear transcription factor Y subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CAAT box DNA-binding protein subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Nuclear transcription factor Y subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Nfyb-L</name>
        <name evidence="13" type="ORF">Hamer_G004159</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUL7"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000110">
        <property type="entry name" value="Nuclear factor Y, subunit B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003956">
        <property type="entry name" value="Transcrpt_fac_NFYB/HAP3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00685">
        <property type="entry name" value="NFYB_HAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="12">
        <location>
            <begin position="49"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7159519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="193" mass="21683" checksum="193B811D52718891" modified="2022-05-25" version="1">MEGAEADDIGASFLSNEQYMVEGHSVHGHQHEDEDKDDVPHLLREQDRFLPIANVARIMKKGIPKTGKVGYNKIAKDARECVQECVSEFISFVTSEASDRCHQEKRKTINGEDILWAMNALGFENYVEPLKIYLQKFRESTKGDKPSEGALEGTFDVDYTNNMTTFSTDHVNQSEIVCTYGPAGQVTQQFTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUS1</accession>
    <name>A0A8J5JUS1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="2">Heart &amp; testis</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025340">
        <property type="protein sequence ID" value="KAG7164532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUS1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035280133" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7390" checksum="5A913C80E6EDBA8A" modified="2022-05-25" version="1">MVTSSSGAALLVLGFGISLEEARPRPLKEKGILSSLTLTTAIAAPKASRPLQEAPYPRYRNVRAINPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVQ2</accession>
    <name>A0A8J5JVQ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G008114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVQ2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="68" mass="7758" checksum="C8355E1355B0B9EC" modified="2022-05-25" version="1" fragment="single">LIMMKLSTRGQENCASLTLVNINNLAVTTGKVDDVRKGRRRRKERSTTYEKDHDDEGKDYDEGKNQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWD0</accession>
    <name>A0A8J5JWD0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine/arginine-rich splicing factor 7-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SRSF7-L2</name>
        <name evidence="10" type="ORF">Hamer_G008063</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWD0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000899">
        <property type="entry name" value="RNA-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF3">
        <property type="entry name" value="SPLICING FACTOR, ARGININE_SERINE-RICH 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7162509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="253" mass="29561" checksum="09D6137D7114E67D" modified="2022-05-25" version="1">MPASLDCKVYVGDLGSGASKQELEEAFSYYGPLRNVWVARNPPGFAFVEFEDVRDAEDAVRGLDGRTICGRRVRVELSTGKSRSRFRGPPPRRGRPFHPEDRCYECGERGHYARDCYRYSRRHGSRYVLCIWGEGGGVALHLVVIAQILRYSRSRSRSRSPRRRRSYTRSRSRSRSRTRDRSHSRDRSRSRERSRSRSRTRDRSRSRTRERSRSPSRDRDRSRSRDDKGDRSRSRTPVQNGSPKMKGEDLNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWM7</accession>
    <name>A0A8J5JWM7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G030888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024705">
        <property type="protein sequence ID" value="KAG7165192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWM7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="64" mass="7114" checksum="903D209E80B3B177" modified="2022-05-25" version="1">MRSDSDYDQLYEEAEEFATKLGIVVPGANTQQHEGSVRSKRVQRISNTLKDICQTASLGSVQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYM6</accession>
    <name>A0A8J5JYM6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger BED domain-containing protein 5-like 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Zbed5-L18</name>
        <name evidence="2" type="ORF">Hamer_G017313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYM6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF19">
        <property type="entry name" value="LOW QUALITY PROTEIN: ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="241" mass="27510" checksum="8FF830DE853646EC" modified="2022-05-25" version="1">MKVEGHGWTAYLVDIFEALNALNLKLQGTNINIIMHHDTIRTFMAKLDLWKCRIQQGNTASFSNLDSALIHGNLDSELKKQIITHLTDLKTEFIRYFPEIDEKLETWKFIRNPFQCEVADVSDEVQEEFLELKFNSTAKEDFKELDLETFCFPVPNSQSPVPSPQSPVPDSQSPVPSPQFPVPDSQSPVPRPQFLFPPAQFLLFCYISSPSAPCLALTRKTHSIDSLCTFSRPYCRIWGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K009</accession>
    <name>A0A8J5K009_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021399">
        <property type="protein sequence ID" value="KAG7167610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K009"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="275" mass="31347" checksum="0AF81EAB3E166B4D" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDSSSDEQEATSDDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERREACRQSPMLASVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0D1</accession>
    <name>A0A8J5K0D1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G004800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0D1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="96" mass="11083" checksum="B85D572DC1A761BE" modified="2022-05-25" version="1">MESDAYYGKLSNVLYKNKGFEKLKKVSQIMSGDAIIDETVQPLTMSDLLCMKHAPIVSCDVERVFSEYKAMLTDNRRGFNFENLRHHVIIKCNHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1T7</accession>
    <name>A0A8J5K1T7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Deadpan-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dpn-L1</name>
        <name evidence="8" type="ORF">Hamer_G004615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1T7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Orange" evidence="7">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7163464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="563" mass="59111" checksum="6DE57AED373B88EC" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2F9</accession>
    <name>A0A8J5K2F9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2F9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="92" mass="10731" checksum="8054ED104C9382CE" modified="2022-05-25" version="1">MIEEDHLLDPSLKNEIIQHLKPLESELKRYFPEFEEEEGKLVRNPFSGTLDIAAIPDDVQGEFLDLRNDSAARDLYEDHTSSPLAIFYYLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K318</accession>
    <name>A0A8J5K318_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G013266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015640">
        <property type="protein sequence ID" value="KAG7169652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K318"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="218" mass="23841" checksum="05D88F80720E87F8" modified="2022-05-25" version="1">MYLDMIGGRATCTWLRALHWLCEEAWLTWEEPPWRLRCTCSVDSGESSEKLFIRKLSFWRRGLMGAVLVASTQLVASTQLVASTQLVASTQLVASTQLAPVCGSRPLSCDNTDYCHNTGGYRKITGCSGEHEESIEYTYAPGAWRSVVVAGRVSMMATTTVGHDGSCVVCVCGPRHAPATSHTLSVTSHAVSIRQVLAEPRVTLVEPQRTAELRVEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K391</accession>
    <name>A0A8J5K391_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019649">
        <property type="protein sequence ID" value="KAG7168672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K391"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="430" mass="48350" checksum="428FBB2E02F4F9E7" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERREVSVSLWQLLNAHRAYLTINSINVVFSLEGMNPLTCMEVYIPLSFEPRITPKHNTISGHHVTEDTGFHSCGCSQLRGSVSTSLPSDVLRKLGHILGQVMVDVAGPRRSCNLEFDVISKVAVKTGGEFVVGKRKVERINDGDASEPTENQGVETCTSPSIKYDPGHRVIMGRLPATTIMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3M0</accession>
    <name>A0A8J5K3M0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATP-binding cassette sub-family C member 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Abcc11-L</name>
        <name evidence="14" type="ORF">Hamer_G021741</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021942">
        <property type="protein sequence ID" value="KAG7166923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3M0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18599">
        <property type="entry name" value="ABC_6TM_MRP5_8_9_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF447">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="743"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="811"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="116"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="455"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="679"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="982"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="426"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7166923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1230" mass="137429" checksum="B536398B95D18A85" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3Z8</accession>
    <name>A0A8J5K3Z8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G010320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3Z8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="66" mass="7096" checksum="C82C7C10292C5AF5" modified="2022-05-25" version="1">MLDDVKTDGENDVVSLQALPFVNLVMPDAEMSPAGILSPLFQPGRQPDGTIWWITGTTVIGLEANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K553</accession>
    <name>A0A8J5K553_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 510-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Znf510-L</name>
        <name evidence="12" type="ORF">Hamer_G010499</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K553"/>
    <dbReference type="OrthoDB" id="6271419at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001235">
        <property type="entry name" value="Si:ch211-119o8.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000706">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7166828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="360" mass="42057" checksum="72FC626A90AB93E0" modified="2022-05-25" version="1">MYEPSCSRGEVYTCEDCGRQFADRQQLREHLVLHNKEEFDCDICNKPFPTKERLQRHKRIHSDKKYVCHECGKIFSVKGYLQKHLEVHSNEMFKCEDCGKFFTLQRSLQSHRLLHKEKKFSCNVCGKSFHKETGKGSLDMHMQLHGDKKFGCNVCGLLFSVKGYLQRHMQVHTKPHKRFECDECGKLFTREYYLKDHMRVHGEKKFGCLECGKLFVRKANLRDHMLIHGEKTFGCSVCGKLFSLKNYLKKHMQVHNSNSGFHDNKYDVMKFTSQDANIAPDEWVDLLQASPCESPTPLELECMGEVKGNKQKTYAKRNAGRDDELQKVLIKAEEGNEDDSQLQFIKMESRSEDESDKVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5H4</accession>
    <name>A0A8J5K5H4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G016083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014436">
        <property type="protein sequence ID" value="KAG7170280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5H4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7170280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="39" mass="4414" checksum="3B4882B9A4F0D6C9" modified="2022-05-25" version="1">MRHCRAGQCYTCRRGDRTAHELLHSRGGGGEKDKTGQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5K2</accession>
    <name>A0A8J5K5K2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutamate receptor 2-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Gria2-L10</name>
        <name evidence="9" type="ORF">Hamer_G016133</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014436">
        <property type="protein sequence ID" value="KAG7170325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5K2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7170325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="173" mass="18936" checksum="F162E40F159A4147" modified="2022-05-25" version="1" fragment="single">VATSGIYHYIGRLITSDKNYVDAPPNGVASVLLGKAAYIDARLSSEIQMMIQGREKFFIGRQSFFPQSYGIVCSKGAFYRDVFDRVLERIVEAGLVDKWKTDEILKLGQGASSAGGLGRAKRGRGPRAITLTHLQGSFFVYVMGLALALLTLLMEQVVNGSHSSYRPKSSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K9P7</accession>
    <name>A0A8J5K9P7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">B-cell receptor CD22-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Cd22-L</name>
        <name evidence="2" type="ORF">Hamer_G024152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013511">
        <property type="protein sequence ID" value="KAG7170787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K9P7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="926"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1155" mass="126446" checksum="AB532E5EDBB2B45F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KE90</accession>
    <name>A0A8J5KE90_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G028088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015590">
        <property type="protein sequence ID" value="KAG7169765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KE90"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="125" mass="13965" checksum="F931C944E60E8FAA" modified="2022-05-25" version="1">MYCKCRGLMPATIVNVGRTLAKKGVKSPSRIGGINGKGQKYGYTGIVFQPCMEVVPWHPYSAVYSMHSDSVISGKRKLEEQDQNEPKRAKITGEIIDPISTFLESFVSTSLDHNELVRQNDLFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KEU3</accession>
    <name>A0A8J5KEU3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4789 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G012508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KEU3"/>
    <dbReference type="OrthoDB" id="6328618at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031993">
        <property type="entry name" value="DUF4789"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21177:SF7">
        <property type="entry name" value="GH11627P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21177">
        <property type="entry name" value="IP06524P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16033">
        <property type="entry name" value="DUF4789"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035177373" description="DUF4789 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4789" evidence="3">
        <location>
            <begin position="73"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4789" evidence="3">
        <location>
            <begin position="258"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7170936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="603" mass="68417" checksum="C97509416242BD7E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KFU3</accession>
    <name>A0A8J5KFU3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein coupled receptor moody-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">moody-L2</name>
        <name evidence="13" type="ORF">Hamer_G013790</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012455">
        <property type="protein sequence ID" value="KAG7171326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KFU3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF74">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="118"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="484"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="542"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7171326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="602" mass="66310" checksum="93AE7EC5B42F8BE0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KI74</accession>
    <name>A0A8J5KI74_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Baculoviral IAP repeat-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Birc3-L</name>
        <name evidence="5" type="ORF">Hamer_G013469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KI74"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051728">
        <property type="entry name" value="RING-FYVE_E3_ubiquitin-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879">
        <property type="entry name" value="CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879:SF5">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7170650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="80" mass="8629" checksum="3678BC37B2014266" modified="2022-05-25" version="1">MEHDGLGVSPQTDSAEKRALEVRLDEAREALTCRVCLDRPVAAVFMPCAHLNTCSTCSASLTTCPLCRSPIHYAAPVIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KJN6</accession>
    <name>A0A8J5KJN6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Digestive cysteine proteinase 3-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LCP3-L6</name>
        <name evidence="4" type="ORF">Hamer_G027371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016296">
        <property type="protein sequence ID" value="KAG7169494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KJN6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="3">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="2">
        <location>
            <begin position="59"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7169494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="181" mass="20096" checksum="3CC46630DE6EAF81" modified="2022-05-25" version="1" fragment="single">VRYYCVAGLTAATETLTSWKLFKARYGRQYESLVEENYRYGIFKKNEERVNNHNLKHERGEVTFTMAMNQLFGGSALHKEGKLVSLSEQQLWTAQGDYGNFGCGGGNMDSAFQYIKDNKGIDTECSYSYEAKNGHCRFNKTSVAPPSGTVYYEPKCSPTMLDHGVLVVGYGTSSSGGGTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKC1</accession>
    <name>A0A8J5MKC1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM122A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM122A-L</name>
        <name evidence="3" type="ORF">Hamer_G017616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM122 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044465">
        <property type="protein sequence ID" value="KAG7154402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKC1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026716">
        <property type="entry name" value="PBIR1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227:SF6">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="493" mass="52411" checksum="6AEABC7B474574B3" modified="2022-05-25" version="1" fragment="single">MPESTMDVDLSGASVSDSEGCGGGSSSTHSSSQAAMSSGNKLKRSSSAPMINQLVLQGPVSNPPLTSASREGVLGDTQGTQPRVRRFSASFGPVSPLSPGSSRGSGPLRVCQLRVEEGMDVVNREAAHERTVQSTLQITDCLSQSWEDLTLPHTIPGSVPTSISTPISVSTNVNTNTSGATLNTTSIRRDFTDPLHLTIVPTVLPLTGCGASPTRGVGRQCFSPSLQQHVRNMSFCPSPSPTKKTFATRRSLSPIALRPSPLGAGLKRKWDVDDRCEPFVTPNKRMSSCAPDRCIGGLLITQPHSVGSLDNSPTPGGPGSLGSVGTPESVCSSESPGLSSQAYSPVEAGVHTPEAPPHLFKPVSPALSTEHTSAFGSQQENDRFVSQNHSSFDNRERNRSFSGPDLSEEFRSGVARDRFLTRDHNDRFSGQEHGGQYQDSCSPRSQFLPQVQNVGFSNQDHSSRREHYGPRGVASYDTETKSLDASDTSSSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKE8</accession>
    <name>A0A8J5MKE8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="13">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 13">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Cct7-L</name>
        <name evidence="14" type="ORF">Hamer_G018224</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 13">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044460">
        <property type="protein sequence ID" value="KAG7154475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKE8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000045">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7154475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="504" mass="55382" checksum="33D2CF3BAE93F287" modified="2022-05-25" version="1">MQPQIILMKEGTDSSQGKPQLISNINACAAVVDAIRTTLGPRGMDKLIVDGRGQATISNDGATIMKQLDIVHPAAKTLVDIAKSQDAEVGDGTTTVVLLAGQFLEQCKNLIEEGVHPHAIIRAFRRATTLAIEKINEIAVKINKKDPVELRSILEKCAGTSLNSKLIHQQKDFFAKMVVDAVMSLDILMPLDMIGIKKESRLIDGVAFKKTFSYAGFEMQPKRYENPKIALLNIELELKAERDNAEIRVNNVEEYQKIVDTEWNILYEKLDLIHKSGAKVVLSKLPIGDVATQYFADRDMFCAGRVVDEDMKRTIKACGGAIMSTAHDLGESVLGTCELFEEKQIGAERFNYFNGCPQTKTCTIVLRGGAEQFLEETERSLHDAIMIVRRALKHDAVVAAYAKALEVIPRQLCDNAGFDSTTILNKLRARHAEGGKWYGVDVMNEDIADNFVACVWEPAIVKINALTAASEAACLILSVDETIRSPRSSADGPPVAGRGRGRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKR4</accession>
    <name>A0A8J5MKR4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine protease hepsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">HPN-L</name>
        <name evidence="3" type="ORF">Hamer_G015596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043233">
        <property type="protein sequence ID" value="KAG7155001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKR4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035153892" evidence="1">
        <location>
            <begin position="31"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="170"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7155001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="444" mass="49459" checksum="BF603D55AD6DDA48" modified="2022-05-25" version="1">MMIMSTSVGPHRSCRSLLLGLVVLVQLSATHRIMMNQRTQSHRRITMQTPAIIRETQKHQDVASKKMQVMLGMCQEDREIELKNIPKTFPLANTIPNPTPEEIAENTITDMVDVMTKVKEKEGNRDPVMNNLMEKMKEMTATMEVNTGIGTHRPGETAQDFEERIKELLSISGIEALLPLDCGRNPRSPMDPLDAELLPWVAALGSSEDGRFHYRCTGALITNQHILTDADCAASANINIVQLNVTKALPEPFAVENYVVGRRIHPSIRGPTDFLNGSNIGLLELAMPVFFNDYIQPICLPGVFDTPDPLALGEGTIVGFNSIIDTPQGRLASLNILRNSRVLGSSICFTAIRLVNERFPDQESTLYTLLTEDHICADRIFESVGKSILLQEDSTTNRVKLVGVGGIANALRSNPIAYTLVQKHRFWVELVLKKFMDNTSERRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLT3</accession>
    <name>A0A8J5MLT3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Dynein heavy chain 7 axonemal-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">Dnah7-L1</name>
        <name evidence="25" type="ORF">Hamer_G012089</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000006">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="16">
        <location>
            <begin position="481"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain linker" evidence="16">
        <location>
            <begin position="793"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="17">
        <location>
            <begin position="1079"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="21">
        <location>
            <begin position="1515"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="22">
        <location>
            <begin position="1866"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="19">
        <location>
            <begin position="2011"/>
            <end position="2243"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="18">
        <location>
            <begin position="2260"/>
            <end position="2600"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="20">
        <location>
            <begin position="2629"/>
            <end position="2804"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="15">
        <location>
            <begin position="3023"/>
            <end position="3142"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="23">
        <location>
            <begin position="3185"/>
            <end position="3273"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="24">
        <location>
            <begin position="3363"/>
            <end position="3545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="955"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3278"/>
            <end position="3309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3700"/>
            <end position="3723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2499"/>
            <end position="2533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="960"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="3289"/>
            <end position="3298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="3700"/>
            <end position="3710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAG7155945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="3840" mass="429227" checksum="28CE4BD0F40CDA72" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMA6</accession>
    <name>A0A8J5MMA6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Actin-2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Act2-L2</name>
        <name evidence="12" type="ORF">Hamer_G006671</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMA6"/>
    <dbReference type="OrthoDB" id="6330576at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0558">Oxidation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7156681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="377" mass="41902" checksum="07B8762560488C83" modified="2022-05-25" version="1">MCDEEDQVALVVDNGSGMVKAGFAGDDAPRAVFPSIVGRARHQGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWYHTFYNELRIAPEESPTMLTEAPLNPKANREKMTQIMFESFTMPAMYVTIQAVLSLYASGRTTGLVCDSGDGVSHMVPVYEGFALPHAILRLDLAGRDLTNYLMKIMTERGYSFTTTAEREIVRDIKEKLCYIALDFENEMNVAAASSSLDKSYELPDGQVITIGNERFRAPEALFQPSFLGMESAGIHETVHSSIMRCDIDIRKDLFANIVMSGGTTMYPGIADRMQKEITALAPSSIKIKIIAPPERKYSVWIGGSILASLSTFQTMWITKEEYDESGPGIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MML0</accession>
    <name>A0A8J5MML0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cyclic nucleotide gated non-selective ion channel alpha 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CNG-L</name>
        <name evidence="2" type="ORF">Hamer_G019301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038152">
        <property type="protein sequence ID" value="KAG7157073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MML0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="330" mass="34570" checksum="F29A433ADBF89B94" modified="2022-05-25" version="1">MWSTAGDLLLSEEAMTVGGGGGCVIFDVSGGCVVCVGGGCGGCLRVSWMLWRVNWSRLWGRVGGGRGYQKSAAGSSDGRGSWGAVMRRHWGVARGDVTPDLPPTREPSLTPLQAGADTTCLITKYCAFGTRGAMGCITPVSPSPWGAGNTSTLPTEPLDVRYLAGGSSQGGPRSPQYPLQPEDPGPPTLGDDQPHHICPCTHCASPEATRVEAGGGGGGGGAGETPQKSVSRVTSLDLTQRNPHHPADPPEHERVLGLTLEGRVYGVCEPSSPLPHTFLTFLTILTPSSPLLHTFLTFLTILTPSSLLPHTFLTFLTILTLPHSFLTPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNB8</accession>
    <name>A0A8J5MNB8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxysterol-binding protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Osbp-L</name>
        <name evidence="2" type="ORF">Hamer_G021472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036980">
        <property type="protein sequence ID" value="KAG7157776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNB8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="99" mass="11357" checksum="15E9130E7BF42EBC" modified="2022-05-25" version="1" fragment="single">VLIELLHLQACNDYVEVSSTAGRKWQRLLQHERDQRVRLEDMVEQLARQHSHLEQEAKEQMNQAMPPGVQNPVPTSSTVEVNVFGQPEQFSLQGEPPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNX2</accession>
    <name>A0A8J5MNX2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endo-1-4-beta-xylanase B-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xynB-L6</name>
        <name evidence="2" type="ORF">Hamer_G021635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035455">
        <property type="protein sequence ID" value="KAG7158359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6357684at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1694"/>
            <end position="1713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2183" mass="240595" checksum="5D662689F790BAF2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNY9</accession>
    <name>A0A8J5MNY9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative pol-like 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pol-L40</name>
        <name evidence="1" type="ORF">Hamer_G027647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035811">
        <property type="protein sequence ID" value="KAG7158062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNY9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="201" mass="22392" checksum="750AC628977A0C33" modified="2022-05-25" version="1" fragment="single">MLKIREDKWLEWCATFNAHTSLSELWRKLRIATGKLPRSPAHPQPLQEANRLTEHFAERSAREGDIKNGLLRAVNLNTDVCNKKTWLLCATDAVNRLKLKDTILSKGSDTMSPENSTPAPWESPPAVFNILQTGTRKADCNPHELRQIAERNMKALTPHNSTVYYTDGSVETTSTKAGAAFTIEGGNTSLWRTSDGCSTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MP03</accession>
    <name>A0A8J5MP03_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">lysozyme</fullName>
            <ecNumber evidence="2">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ilys-3-L</name>
        <name evidence="10" type="ORF">Hamer_G008948</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MP03"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16890">
        <property type="entry name" value="lyz_i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008597">
        <property type="entry name" value="Invert_lysozyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11195">
        <property type="entry name" value="DESTABILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11195:SF13">
        <property type="entry name" value="INVERTEBRATE-TYPE LYSOZYME 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05497">
        <property type="entry name" value="Destabilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51909">
        <property type="entry name" value="LYSOZYME_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="4" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035313605" description="lysozyme" evidence="9">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="29"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="80"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608597-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7158300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="146" mass="15767" checksum="D700A6B19265AFB6" modified="2022-05-25" version="1">MKTALVGVVAAIMVAIVHSQDANCLECICQASTGCNSNTACPDGVHCGPYLISWAYWSEAGNLTLPYDQIPAGQGVYDSCVRNPQCAVQTILGYMARYGKDCNGDNLVTCTDYVLLHKLGRNGCPGALSGDFGYKYEICRKHYNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQN0</accession>
    <name>A0A8J5MQN0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Alp-m-L1</name>
        <name evidence="13" type="ORF">Hamer_G012702</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQN0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="396"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="398"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7160161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="433" mass="48777" checksum="FF49199CA378A377" modified="2022-05-25" version="1">MGMANPGSSVVREVMTAGGWVMLVSLRSVVVSYTHTHTEDQYYWNNLAQEELSRTMNVKQNLGVAKNVIMFLGDGMSVPTITAARIYKGQKENRGGEEGSLTFETFPHVGLSKTYNVNKQVSDSASTATAYLTGVKTNYKTIGVDGTARYKDCSSVNEKNKVSSIVKWSQDAGKRTGVVTSTRVTHATPAGTYAHVADRDWECDGAIPKEAIKLCGNKVKDIARQLVEDEPGHSLNVVMGGGYQNLDAFAVGTPDDPLDTQWANCTRTDKRNLVQTWMNKKKSDGVTWAFARNKTAMLEVDTTNVEFFMGLFANGHLPYEFEKIQKKLDVPTLAEMTETAINILKQEPKGFFLLVEGGRIDHAHHDTVAHRALDETVAMDRAVEMALKLTSQEVRYSLQRERERERERERERARERERERARERERKREREFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRI4</accession>
    <name>A0A8J5MRI4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FRG1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">frg1-L</name>
        <name evidence="2" type="ORF">Hamer_G007709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRI4"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23338">
        <property type="entry name" value="beta-trefoil_FSCN_FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
        <property type="entry name" value="FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="265" mass="29420" checksum="6554BAF9E8B00A00" modified="2022-05-25" version="1">MSDYTNVKVGKLKLKGEKRSHKKHKSKKRKSEDEDGSHSSKTSKDTDTADHGGWWLCSTLHQMTGALAIQLGKSPVYVRALDNGLFTAGAPHDEGDGPSPEEVLTAVPAGDDRIALKSGYNKYLGVDGAGRVVGRADAIGPREMWQPVFQDGETALLGANECFLGLDDEDNVVAKCLKAGPEQMIIIRSNSLRECDKPKEIPEEERGKLNDVEKNYVKKFQKFQDKRLRINKDGVAELKRARNEGALHEALLDRRSKMKADRYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSA4</accession>
    <name>A0A8J5MSA4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G022850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029263">
        <property type="protein sequence ID" value="KAG7161481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSA4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="103" mass="11176" checksum="266E29DA2F9FE5A8" modified="2022-05-25" version="1">MRVGGGAPAGTRSCRPGRQPLMSHLHRYLASHTWPTHVFPPYTPAPLPRLPHLAHTCDSSLHICTATSPPTPGPHTCNPSLHTCSSTSPVVTQEHVVFTRTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MT09</accession>
    <name>A0A8J5MT09_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ferrochelatase</fullName>
            <ecNumber evidence="13">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fech-L</name>
        <name evidence="14" type="ORF">Hamer_G002206</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:22586"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="13"/>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MT09"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7163130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="407" mass="46536" checksum="52B6D168AE0631CA" modified="2022-05-25" version="1">MRRTMLFKSFLKSGYGPLLSKICRLTTSSNFYGLEAPQTSENATPTTTPKTGILMLNMGGPRTLDEVHDFLLRLFKDRDIIQLPVQDYMGPWIAKRRTPSIQEKYDEIGGGSPIFKWTDIQGKLLCERLDAQCPESAPHKHYIGFRYAHPLTEDTLQQMEDDGVENCIAFSQYPQYSCSTTGSSMNAIHQFYAKRSEESRMNWSVIDRWCTNSFLVKCFAENIQKELDQFPKEKQKDVFILFSAHSLPLRQVNRGDPYSAEVGATVQLVMEQLGFSNPYRLVWQSKVGPLPWLSPATDEAIKGLVQRGRRNMILVPIAFTSDHIETLHELDIEYAKDIGEEVGAECIRRCASPNDHPHFIEALVDVVSSHLNTSHRCSEQFLHNCPLCVNPSCFASKKWFRYMTKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTI3</accession>
    <name>A0A8J5MTI3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative kinesin-like protein unc-104-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTI3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="63" mass="6751" checksum="1005C708DD06996A" modified="2022-05-25" version="1" fragment="single">MPATDSDNMSEAERATALKFARFMQGRSVQIHTKQETPAQTPDEQDALTASVTSSCSSTTSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU05</accession>
    <name>A0A8J5MU05_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7162994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU05"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="537" mass="59483" checksum="73D4CA812A492085" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUM8</accession>
    <name>A0A8J5MUM8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione peroxidase-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GPx-L3</name>
        <name evidence="4" type="ORF">Hamer_G004808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUM8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF81">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7165050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="117" mass="13778" checksum="9F761DA6AF58CE77" modified="2022-05-25" version="1">MLWQEPAGNGQELLNGIKHVRPGGGFEPNFTIFKKINVNGEDEHPLYTYLKEYCPATRQSFADPDYLFYTPLKTNDIRWNWEKFLVSKNGKPYMRYDPGTKPKDLKNDIMFLLEQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVM2</accession>
    <name>A0A8J5MVM2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024230">
        <property type="protein sequence ID" value="KAG7165503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVM2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="961" mass="106729" checksum="0059E40F1EE5FBFA" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVX8</accession>
    <name>A0A8J5MVX8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVX8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="59" mass="6827" checksum="A914A30AF5BE4A33" modified="2022-05-25" version="1" fragment="single">VQPRDKMCYAALGETVHSSEQYEVLCIDKGSRLSCVKNYYKYAVLGSWKNHVRPPHNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MX44</accession>
    <name>A0A8J5MX44_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022377">
        <property type="protein sequence ID" value="KAG7166582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MX44"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="619" mass="70549" checksum="257BC607D76D53F7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY81</accession>
    <name>A0A8J5MY81_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein Hsp-16.2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Hsp-16.2-L</name>
        <name evidence="5" type="ORF">Hamer_G011547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY81"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="93"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7168875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="204" mass="22871" checksum="45243B6A26987E50" modified="2022-05-25" version="1">MTLIRAKRVASGMQRSIFKAVCVPGSPAKISSTMAPACSRCFNRGPPWRRDPFSQMEEFMRDMERKFKRDIDSSLSSFFREFPRVGETLSQPISSAVTRPGFGHVENLSTEEKYKLAFNFSSAKPEDIKVKLKDRTLTVTGQAKTSTETSRSSYETSIEYQLPDGVDVDALESSLSHDGILTIEAPQITPEEPQTPQPIDINRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYL5</accession>
    <name>A0A8J5MYL5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="3">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Plce1-L</name>
        <name evidence="9" type="ORF">Hamer_G018352</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7167929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08596">
        <property type="entry name" value="PI-PLCc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01780">
        <property type="entry name" value="RA2_PLC-epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17114">
        <property type="entry name" value="RA_PLC-epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000183">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000238">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046973">
        <property type="entry name" value="PLC-epsilon1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028398">
        <property type="entry name" value="PLC-epsilon1_RA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF6">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="218"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="6">
        <location>
            <begin position="1326"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="1499"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="8">
        <location>
            <begin position="1678"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="8">
        <location>
            <begin position="1820"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="772"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="824"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="906"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1205"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1282"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1948"/>
            <end position="1970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1982"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="907"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1222"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1239"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1282"/>
            <end position="1292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7167929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2028" mass="228712" checksum="EBAF4B5059666F75" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZV9</accession>
    <name>A0A8J5MZV9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G032017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015529">
        <property type="protein sequence ID" value="KAG7169774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZV9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="100" mass="11857" checksum="B10094CA2C2FECAD" modified="2022-05-25" version="1" fragment="single">PLYQTCAFHALVFLDYVTSCELDDSWLIMHHFKRQMGRHTERTAILRVLRMIHELPFDIDMSAHWTGYNSLLPSYTPVHTHNVLRCRAQRYGRFYDVGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N190</accession>
    <name>A0A8J5N190_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 10 member 6-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Slc10A6-L3</name>
        <name evidence="9" type="ORF">Hamer_G013750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012455">
        <property type="protein sequence ID" value="KAG7171292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N190"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF28">
        <property type="entry name" value="P3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7171292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="443" mass="48536" checksum="A430A4292194656C" modified="2022-05-25" version="1">MCPLYPVHLVLMYGAVLVCVWVAGLGSVVTAAAEVATLKVRLQLSNNNDSTNNILSVKEGEVKQVTFYIDDLPPQAVGDILIKDESDDKLNHLKIAPNKIPLSPALTENMENGSVEGSFNITGNFLGFTKIKLVLSDGKDDELLVSKPVDVSVQRGQRVMDKIFIHVVIAMVIVAYINMGCAIDLKVIKQTLCRPVAPAIGLFSQYLFMPLISYAIGYGLFYDTPAMWLGLFLTGCSPGGGGSNMWTYLLGGSLDLSVTMTFISTVGAFAALPLWVYALASTIFKEGHFSQLPYKNIAMLVVGLVLPLSIGLLIQWKSQKVAVVLKRLLKPVSIIFIIVMMTFGVYANFYIFSFFDWKVALQEFAPLGDVTMVIPIAVATMTPIPLTIAYIIKRIREYRKQSFSKDVEFPFDDEEARNGHLSSSNSATPLHKDANGNSKMVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1H1</accession>
    <name>A0A8J5N1H1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inorganic phosphate cotransporter-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Pht-L7</name>
        <name evidence="7" type="ORF">Hamer_G018594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012106">
        <property type="protein sequence ID" value="KAG7171475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1H1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="18"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7171475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="467" mass="51170" checksum="010E69038EAC1045" modified="2022-05-25" version="1">MKPPTLKEQGYLPSRYLVALMAFLGMVFNYMLRVNINLTIVAMVTNDNSTSPVQDVCHFKDDNDQTEDYVRGRLAEVLGARRVFGGAILSASIVTMFVPLAAKSSASTLIAVRILLGLSEGATFPSTHALLATWAPPYERSTLSTIIYAGSQAGTIIGFPLAATIIDSLGWEAVFYIQASLTLVWCAGWFLLVADTPDSDSRISKVERDYIYNSLGGSKEKKAPPVPWRSALTSLPFWAILVAGVGNNWGFYTLLTDLPLYMKQMLQKDIKSNAVLSGLPYLGMWIFSLVVSSVGDRLRQNDTLSTQTVRKTANTIAVTLQGGIYTGFMVNHVDIAPNFAGTLFGITNAAATIPGWVAPMTVGALTNNQQTFGQWRKVFFISAGIFVVDALFFLLYASGKEQEWNKVPEKSVKKDLKDAVVTGQKSPPGVNMLQEGTTDMLDSEAYSKYILNSNFRNSYQNKAFQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1J6</accession>
    <name>A0A8J5N1J6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Paired box protein Pax-6-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Pax6-L2</name>
        <name evidence="13" type="ORF">Hamer_G018590</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012106">
        <property type="protein sequence ID" value="KAG7171471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1J6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000516">
        <property type="entry name" value="Transcription factor Toy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF44">
        <property type="entry name" value="PAIRED BOX 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="109"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="111"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7171471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="344" mass="37847" checksum="9D94358B0C22911D" modified="2022-05-25" version="1">MTRDPNYDPILNYGPILNYGPILNYGPIPNYDPIPNYDPIPNYGPIPNYGPIPNYGPILNYGPILNYDPHTKLQRFPSTSDAGELSEDSNAGSSENSSSEDQARLHLKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAAKIGLPEARIQVWFSNRRAKWRREEKLRNQRRAAEGVAPSSPTRIINNLFTPTPMYTPLPPPPMSVADTYGSMAGAGFGMPSSVGPVASSPNCLPPQQPPTVVHSGSPGAGGMTLTRDNSHAHNPYMSRPTYDTLYTHARASHLPAHVVSPSLSPPPVSTNTPTPPNSQAGLLSPGVSVPVAVPGQHHDMNTQYWTRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1U6</accession>
    <name>A0A8J5N1U6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G031049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011764">
        <property type="protein sequence ID" value="KAG7171733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1U6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7171733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="118" mass="12745" checksum="688473DC52E0AEF4" modified="2022-05-25" version="1" fragment="single">MAAVDEYSTTSHVLQLCLALQDRLEKVEKEVQSLKGENLALKLVLEEKKTFASVVKDGEVEVDSWKVVAASATKCTLKRHSAVDLNNRFSTLSDECKEGASNTTSATPSVSVERGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1W8</accession>
    <name>A0A8J5N1W8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger BED domain-containing protein 4-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Zbed4-L7</name>
        <name evidence="7" type="ORF">Hamer_G014793</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1W8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="111"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7171650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="199" mass="22967" checksum="695906F45BE43F29" modified="2022-05-25" version="1">MVVEHDNGGELDNTSWRKQKRLVRHRPLIPCEELQKEKISKIVDLIIAESTKDYKEKVQKEEIQENELSMSINQDKDGIIAKRPRLFAYMPPPGPSMASPSTNHTTVVKTELETYLEEGVLPFDINPLKYWRDIQSFKSLRHFVKNILGCCATSAPSERVFSKAGNFYTPERAKLSPEIFRALMMIKCNSDMWVLGLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N246</accession>
    <name>A0A8J5N246_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homologous-pairing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">psmc3ip-L</name>
        <name evidence="9" type="ORF">Hamer_G000668</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N246"/>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="7">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="8">
        <location>
            <begin position="149"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="80"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7171758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="211" mass="24545" checksum="FDDA7EF10CA37074" modified="2022-05-25" version="1">MSKKEAEATEKIKSYLEQQNRPYSVNDIFMNLHKEVGKTAVQKCLDKLVANGSVKEKTYGKQKVYVIDQEQFPALDEQKLKKMDMQLVELNQTIKESEKECVEVEAKLRNLNSSLTTEEASKRVTQLDEEVSKLQQRLSDLQENQVMVSKEEKDKISKANEEMVKQWRKRRRMARDMLDAILEGYPHPKKHLFEEIGIETDEDVGVNLPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2R1</accession>
    <name>A0A8J5N2R1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G001033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2R1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035187398" evidence="2">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="189" mass="14695" checksum="C435E3C918985312" modified="2022-05-25" version="1">MKLVLVFLGVILLAVSCLAMPGYGGGGGGRGGGGGRGGGGGRGGGGGRGGGGGRGSGGGGYGGGGGGAATGGGGGSGGGGGTGGYGGGGSGGSGGGFGGGSFGGGGYGGGGFSGGGSGGGGGGFGGGGFSVGGYGGSGSGVGGSGGGGYGGGGSGGGFGGGGFGGGVGGGNTGGGGGGSGGGGYRGYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3I3</accession>
    <name>A0A8J5N3I3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain-containing protein SmydA-8-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SmydA8-L9</name>
        <name evidence="3" type="ORF">Hamer_G020124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010583">
        <property type="protein sequence ID" value="KAG7172566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3I3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053010">
        <property type="entry name" value="SET_SmydA-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455:SF7">
        <property type="entry name" value="RE12806P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="54"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="567" mass="64994" checksum="A1ED54B487C3AAC7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N607</accession>
    <name>A0A8J5N607_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Samhd1-L1</name>
        <name evidence="1" type="ORF">Hamer_G003088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N607"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="9580" checksum="31022D512F4C19C4" modified="2022-05-25" version="1">MTLYVAEMMLNSSDPDEMHSDPQVSIGVNEKVFSDAIHGAIFLHPLCVKIIDTPQFQRLRFVKQLGSVYFVYPAAAHSRFEHSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N661</accession>
    <name>A0A8J5N661_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008527">
        <property type="protein sequence ID" value="KAG7173932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N661"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="172" mass="19495" checksum="08E14436EFCB07C7" modified="2022-05-25" version="1" fragment="single">LYSAESHTKRYRDKEAKGHNGLFHAGIQSYIHDFRCRVLLDSPSSRHTSTANMSSKVTFQDTWLQKPEFQPWLTREEGDSKRAYCKICKSGFGTEISTIRRHKKAKMHVANEGKADQQESGPSTPNYSLSGVAFATILLCCFIAEHNLPFTIAEPLVKLQKRMFPDSTIAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7L7</accession>
    <name>A0A8J5N7L7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7L7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="316" mass="34881" checksum="3C8126CE1A1583E3" modified="2022-05-25" version="1">MCHSAGTVGDLGQARSQRVWQMMGGCRVGGSGGGCRVGGSGGGEGRWQLRSCVGMWLCGCRCVGAGMWLHGCRCVCGCVVVCGCGCVGVVDCIGVWVYGCKCVWCVGVGVWVCGCICTDLWVSECRCLSTGYRCLSVRVSEYRCLSRDFWVQISEYRYLSTGYRFMGTGVGCPGAGINVWVFEYSCLGTGVWIPVSEYRCLDRSVWVPGCKCLCVWDPVSRMVQKLLTKFADEVVVMVRKTLLDIIILRLCCACVWMFWYRLQMYRYLGVLVLWVTRCIGLRVSGFRFQGTGGIEEAVCSTKTIRRGLSQGMSFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9B7</accession>
    <name>A0A8J5N9B7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Ugt2B13-L</name>
        <name evidence="6" type="ORF">Hamer_G001172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9B7"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035488927" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7175164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="514" mass="58847" checksum="F2F7B0A1B640E1E3" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAA9</accession>
    <name>A0A8J5NAA9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tigger transposable element-derived protein 7-like 56</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TIGD7-L56</name>
        <name evidence="4" type="ORF">Hamer_G000044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAA9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF17">
        <property type="entry name" value="TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7176855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="9607" checksum="4C4F772319658C54" modified="2022-05-25" version="1">MGIENFEASDGWLWRFRNRHGMCNKITHGEAGSSPTEDIKPFRERLNDLIKSEGLLISQVYNGDETGGPYPGIPKHSRMKPPHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NB70</accession>
    <name>A0A8J5NB70_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-Cys peroxiredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PRDX6-L</name>
        <name evidence="11" type="ORF">Hamer_G000033</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [protein]-dithiol = [protein]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:10008"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NB70"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="2"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7176845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="219" mass="24320" checksum="9191C34E8D60C7FE" modified="2022-05-25" version="1">MVNLGDVFPNFTANSTVGTIKLHTYLEDSWGVVFSHPADYTPVCTTELGRVAKLVPEFTKRNVKLMAISCDSVEDHHGWIKDIQSYNCLSGDFPFPIIADPDRDLAVTLGMIDPDEKTATGMPLTCRAVFIIGPDKKLKLSILYPATTGRNFDEILRVIDSLQLTAVKKVATPADWQQESHCMVLPSIPAEEAKKIFPEHKVHQVPSGKEYLRTTPVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBG9</accession>
    <name>A0A8J5NBG9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cuticle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBG9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="151" mass="16911" checksum="EE3C76E32672FC89" modified="2022-05-25" version="1">MRREGKECCIFHWSVTKELLTVLTTFTCSLLQLSLRPALFGQTGPTGSVWGYIRELLHQPDIIVLDASPHTRHEALVPTLTWVTNNLHLPPHSSLSYPLPDGSFAEVSYTADEFGYNVNSPLLPTPHPLPAHAQEQIRIAEEQRAQGITFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NC47</accession>
    <name>A0A8J5NC47_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NC47"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="101" mass="11086" checksum="2C685916ADBCF97B" modified="2022-05-25" version="1" fragment="single">GEKVLGWVREAAYAAGVGTREHEALIVLIARMEATPLAVHNWGMESLSARTLVSLSKVVVTYLVVLLQFCSYSSSLNHYVPNDAFVFTAYDHCFCSNNTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ND67</accession>
    <name>A0A8J5ND67_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G016194</name>
        <name evidence="2" type="ORF">Hamer_G028048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014436">
        <property type="protein sequence ID" value="KAG7170374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010000325">
        <property type="protein sequence ID" value="KAG7178265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ND67"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7170374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="147" mass="17232" checksum="65B72763746191E8" modified="2022-05-25" version="1">MTFLNKEYRPYVGSESFQFFAQDNLRFSDNINERVLRDELGETYIKFCTERNLPVASMVNIGAHLAQSGVCVKRLGTRFGQQYGYCHLQWIDPTGFTKYFPIYKKADKEVCPKLPKYKYKPPIEKPPPVNREPVKVIVLQCVKLRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDW0</accession>
    <name>A0A8J5NDW0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G016742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002318">
        <property type="protein sequence ID" value="KAG7177448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDW0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="162" mass="18976" checksum="B9AD6C0E8FBE43A7" modified="2022-05-25" version="1" fragment="single">KRVLLPRKYAVNTEFQKSASDIRKYKDKLHKYAMKFNVDQEKSGIRRMRKVGNEDLEEAVYKCSYSNVREKFKDLMDAKNFQLCQLYNADETGLFWRALLKNIQASRSKKVCPVGNFQKSECLQMPMRAICLHVQLSQFCCFCQRSKGNNPHQILGEAPLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NGF5</accession>
    <name>A0A8J5NGF5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NGF5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="77" mass="8668" checksum="4B462D8B72AECEE2" modified="2022-05-25" version="1">MSPAIHPVTDPPTFAIPTVMKYKIPKETEFNHAYEVVVALELEYKNIKFSVKPNLAGDLILHPPPTPPRPQHSQDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NKF5</accession>
    <name>A0A8J5NKF5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G030250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000098">
        <property type="protein sequence ID" value="KAG7178301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NKF5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7178301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="110" mass="12398" checksum="8B06502C235AEB99" modified="2022-05-25" version="1">MEGKCHKRLRKEDDFSDMANMSRAIHPVAEPPTVAIPTVMKYKIPKETEFDHAYEVVVALELEYKNIKFSVKPNLVGDLILSPQDHNTAKILSEVSNLNGKAIKIIPLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T4K6</accession>
    <name>A0A8J5T4K6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tyrosine 3-monooxygenase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ple-L</name>
        <name evidence="10" type="ORF">Hamer_G020119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010583">
        <property type="protein sequence ID" value="KAG7172561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T4K6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004511">
        <property type="term" value="F:tyrosine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048066">
        <property type="term" value="P:developmental pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006585">
        <property type="term" value="P:dopamine biosynthetic process from tyrosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.800.10:FF:000004">
        <property type="entry name" value="Tyrosine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019773">
        <property type="entry name" value="Tyrosine_3-monooxygenase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF15">
        <property type="entry name" value="TYROSINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000336">
        <property type="entry name" value="TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="9">
        <location>
            <begin position="81"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7172561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="429" mass="49441" checksum="F176F145CEC7F8F0" modified="2022-05-25" version="1">MRINMFITVYGCVYLASHHLAYTLTSWSLRQNFKGHVAHVETRPAPRKGVAFDVLIKIDILREPLLNLLKSLRQGSAIASVNLLSEHHSSIKEAWFPKHISELDMCNHLMTKFEPDLDMDHPGFADKEYRARRKEIADIAFTYRYGDPIPRVAYQQEEIDTWGAVFKELERLIPTHACRQYREVWEILKRDCGYTPDQIPQLEDVSKFMKRRTGFTLRPAAGLLTARDFLASLAFRVFQCTQYIRHHSSPHHSPEPDAIHELLGHAPLLAEPAFAQFSQELGLASLGASDHEIEKFATMYWFTVEFGLCRESGDVRAWGAGLLSSFGELAHALSDKPSKKDFDPAITSVQPYQDQDYQDLYFIADTVEDAQEKFRRWTFQTMSRPYEVRYEPHSQSVQTLDSVHKLEDLTSSLTSEIQRLNNAVRKMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T7F5</accession>
    <name>A0A8J5T7F5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin carboxyl-terminal hydrolase 12A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Usp12a-L</name>
        <name evidence="4" type="ORF">Hamer_G008695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T7F5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF905">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="110"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7173161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="547" mass="61047" checksum="FAF17870EA435F98" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5THY4</accession>
    <name>A0A8J5THY4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Involucrin-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">IVL-L5</name>
        <name evidence="2" type="ORF">Hamer_G030904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005508">
        <property type="protein sequence ID" value="KAG7175559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5THY4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="298" mass="32600" checksum="D83E50B3029A8309" modified="2022-05-25" version="1">MKRTSLEVATEDTPRAVVTEETPLKQPTEEDTPMEVVTEEDTPLEVVTEEDTPLEVVTEEDTLLEVVTEEDTPLEVVTEEDSPLEVVTEEDTPLEVITEEDTPLEVVTEEDAPLEVVTEEGTPLEVITEEATPLEVVTGEDTPLEVVTEEVTPLEVATEGDTPLEVVTEEDTLLEVVTEEDTPLEVVTEEDSPLEVVTEEDTPLEVITEEDTPLEVVTEEGTPLEVITEEATPLEVVTGEDTPLEVVTEEVTPLEVATEGDSPQEVPRRAAAQKLRANRPPHQAKNTFVPGAKGHLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIN4</accession>
    <name>A0A8J5TIN4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Organic cation transporter protein-like 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Orct-L13</name>
        <name evidence="7" type="ORF">Hamer_G016988</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7176024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIN4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7176024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="165" mass="18414" checksum="887321A4EDE68376" modified="2022-05-25" version="1">MYVDYLVVGMVYFGLSLSGGNFSADPFLYMTLTGLVEIPSNTIIIPFVARFGRRSLTVLFYLLSGVLLLTLPFIPARIGWLIVTLALVGKMTITSVFNIIFLYASDLFPTEVRTRGMGTSLMMSRVGSMTSPFINDYLNQGDSRQIKLKVVSHHNSCKKWVQPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKS3</accession>
    <name>A0A8J5TKS3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKS3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="77" mass="8754" checksum="AA115994D0C2CAAE" modified="2022-05-25" version="1">MAELPVKHPEVYREVKIPSIQISFAKDVRSLVNMMEGLRIPFEEKSTNLVALDAKEISGAVVVKTVRNVKRTSRKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TL58</accession>
    <name>A0A8J5TL58_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MIT domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MITD1-L</name>
        <name evidence="2" type="ORF">Hamer_G015489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TL58"/>
    <dbReference type="OrthoDB" id="19553at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02685">
        <property type="entry name" value="MIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052817">
        <property type="entry name" value="MIT_domain_contain_protein1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032341">
        <property type="entry name" value="MITD1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21222">
        <property type="entry name" value="MIT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21222:SF1">
        <property type="entry name" value="MIT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16565">
        <property type="entry name" value="MIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="1">
        <location>
            <begin position="36"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="274" mass="31809" checksum="DC3435117041DFAB" modified="2022-05-25" version="1">MKLEQRRHRPLRDKILISTYRNKCQSTVRKTDKMSGGGPEAAAVQVLTRAVQLDNEKKFAEALACYEQGIRLLLQAEKEVNDEGKRSHFRKKTKEYLSRAEAMKEAAAKQRTMGRTHKQIQVEAGATGYSYETIFGPLLDKTLSSVVVEDAYIRSTHQIYNFLHFCELLVLKAECLRSITLRTTRDPSGHGIQHERLSEIQQSLEKHSIKFTFIFSDTIHDREIRFDNGWIIKIGRGLDYFRKADGRFSLGWTEYHFRQCHQTTIDIFHQQSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TN17</accession>
    <name>A0A8J5TN17_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vigilin-like 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">vgl-L28</name>
        <name evidence="4" type="ORF">Hamer_G028828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005280">
        <property type="protein sequence ID" value="KAG7175608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TN17"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="193"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="272"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="361"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="440"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7175608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="515" mass="57469" checksum="C341B5AD02C364B0" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TT10</accession>
    <name>A0A8J5TT10_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Exosc7-L</name>
        <name evidence="9" type="ORF">Hamer_G000134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TT10"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11367">
        <property type="entry name" value="RNase_PH_RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="13"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="179"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7176928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="271" mass="29633" checksum="8B40EFE28B265F67" modified="2022-05-25" version="1" fragment="single">LGIRVDGRDRLDYRQLEIETSVVSTANGSARVRLDHTDVLITVKMEMEPPLIDQPRNGKLYFFVNCSANAAPEFEGRGGEDLGTSLSSMLERVYSSPHTLDTSKLCVVPGKYVKGLYVDIEILECGGNLFDAVSLGVKAALWATKMPRIYITGEDGGELEFSVSDNPCDVDRVDVSNAPILITHLRITENLTVVDPTPEEECCGPVQIVVGVTPKGLITATQQLGSGTFTPQTLSASIKSARDLGVKIHQRLMEKLRQEENITDRPIKGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J015</accession>
    <name>A0A8J5J015_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G019501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046371">
        <property type="protein sequence ID" value="KAG7153602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J015"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="107" mass="10927" checksum="2D79635339225BBD" modified="2022-05-25" version="1">MRVALGGPAVLCPAGGVVSSSSSPRAGLAGASVSVAWPCHALSSLAASRLPVCCCWPHPVFTLACPDPICQLLCLCQAQAQVAGGNTDMLYPTRGETSLLLNVLMFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JD03</accession>
    <name>A0A8J5JD03_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041877">
        <property type="protein sequence ID" value="KAG7155371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JD03"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="205" mass="23200" checksum="05C823CDB2312787" modified="2022-05-25" version="1" fragment="single">LFLLVVVRGQDGTVAVVSIPGVSGYLTNPCHLQEQNPEGGDDRNPALSFDQVRRVAYSNIHFANASLISIQTILNNECNTPFSLNTLPALPVIDDTTQQDAFRQMHRELIYLAAHLYFAINNTDHTNTFCSHETSQFSLHLRRLTGMLENLLCRLTVMINNREQLTPVLEEVTTLHLLHEASCGGRRLWMCILISRTRRALVMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDI7</accession>
    <name>A0A8J5JDI7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDI7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="244" mass="26232" checksum="8AD7424463A32410" modified="2022-05-25" version="1" fragment="single">ASKVKLFNAVRSQLFGDSVDVGLREDHGEASQVNVAESRSVNDELRLLESQIKLKEAEAKAKESKAIAKEVGIRQAEADSENLRHKAEFCWTRLQLNTGKPAMIVTAEANMSQVGVMAGLSKADSMPIALVSTKGEARESAVSVLASRDFDLFQESFAKDPDVGTFRPILSQGTVEVDGVETPVTILRNSGCLQTLIKEGVVAVRKTDKYVVLGSLWGQEIANVACVHELPVAGVDLILGNNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEF9</accession>
    <name>A0A8J5JEF9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tigger transposable element-derived protein 1-like 45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIGD1-L45</name>
        <name evidence="5" type="ORF">Hamer_G031446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039313">
        <property type="protein sequence ID" value="KAG7156225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEF9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF26">
        <property type="entry name" value="TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="61"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="547"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="557"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7156225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="582" mass="66021" checksum="9FFED1D3A2E50997" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JF37</accession>
    <name>A0A8J5JF37_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytospin-A-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Specc1l-L2</name>
        <name evidence="6" type="ORF">Hamer_G018191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytospin-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044460">
        <property type="protein sequence ID" value="KAG7154450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JF37"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000020">
        <property type="entry name" value="Cytospin-A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF69">
        <property type="entry name" value="FI18193P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="290"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7154450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="396" mass="43321" checksum="4DEEE03A329CF191" modified="2022-05-25" version="1" fragment="single">VEEWEQFQSDLLMTVRVANDFKTEAQHDLERLTQENAMLRDRLKQLGQDLEKAKAVKVCSPVSNSSNTALNNGSSERRAVRAVPSSLPNGDPSILTDRRNPRPLARGDSRVKSLIESIESATRQTRAGSRSSSTSSLCSTSSESNINNNNKTSTPILKRADTECVIRGVSSSPLKDAGNTLGSSSASSPRRAIQRNSFTEGITQSSLNQSTFSKPNPGSSNLSDNVKMSQLTDKSSGKISNLGSGENNVSKPISILSSKLDHSMRRNSYGQISAVVDKKDPLASLAQSGGSKRNALLKWCQNKTLGYINVDITNFSSSWNDGLALCAILDTYLPDKINYKYLKPQNKRQNFQVAISAAESVGIPNLLDVDDMITSERPNWQTVYNYVTSIFCHFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JG66</accession>
    <name>A0A8J5JG66_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040097">
        <property type="protein sequence ID" value="KAG7156104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JG66"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF23">
        <property type="entry name" value="MYB-RELATED TRANSCRIPTION FACTOR, PARTNER OF PROFILIN-LIKE ISOFORM X2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="266" mass="29322" checksum="F3C56D69C7A1D951" modified="2022-05-25" version="1">MRVTRNVTEIRRKFSADLRVSVKKKAAQDKKYAGGTGGGPQIEITYTAIEEAILQLLDPASIHGIPGDVESEEPINEEEREPTPGPSGARFTATGSCFREEFMFRPVQEKDDSITRILNEDIQEHDITVPIVHLEPEISAPTNIPGFSSSGTYEVETCSSSNTRQPIAATKEQRSRSSTPSATAVRSTVTGDYTDEMDSSPMPSTNSSGRRPRTSSARKDEDLLREMLRVQTQMRDSFLQLVAHTECIASAMLCIAKVMQSKNPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGX9</accession>
    <name>A0A8J5JGX9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035946">
        <property type="protein sequence ID" value="KAG7158042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGX9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="296" mass="33218" checksum="E728B541CCF25B26" modified="2022-05-25" version="1">MDDDDLLAARLLGMGRNTGRRSSESGLATDFWGRSSTPGGTLNDSGIFGSSRQKPARKSRKPRSWHPSPYASDDEDDLLSREEKKQKIKAEISRRRQQIEENSRLHEELLRLARLRESAELGYSDPRAYGPYDQSPPQSARDSTTSVLRSIDEILRDARDPSSGYYSGYSPYKAGGSPPNRYGSSPGARTSPRHYYGSRGPSPSHYPMTEEDRSMARLASTFQSDEFTGALYERLSDFSPLTADSLSDSMSDFTPAMPLLPDMPTRSRKLLEDLGSSPITSQTHRGKYDIQRRYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHB4</accession>
    <name>A0A8J5JHB4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G010050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHB4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="248" mass="28178" checksum="FDE6021159E07129" modified="2022-05-25" version="1">MNTFPTASGIVLAELVLYIDETRIEEGRATVFKLADLAHLYQSRMEQLGFKFDTRVHFTRIQTQAPCRHTTRDSRHKPCSSHHHQLLKFTSIKHKWVHNATTSVTERHSTSQETPVPLYMGMMLHAHTRNRELVDRLPHLGPSISYDRVLRLSAQMGINVCQQFHNTSATTAKTSFHGTSISLLQHSSFPGEGVDRSIVILGRSENASSTILLAIYHTTTQMCFLLILASRSHLPQHPQPHHWQETSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHG0</accession>
    <name>A0A8J5JHG0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Unc-80-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Unc80-L2</name>
        <name evidence="4" type="ORF">Hamer_G017582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044465">
        <property type="protein sequence ID" value="KAG7154378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHG0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031542">
        <property type="entry name" value="UNC80_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781:SF1">
        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15778">
        <property type="entry name" value="UNC80_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Cation channel complex component UNC80 N-terminal" evidence="3">
        <location>
            <begin position="62"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7154378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="457" mass="51570" checksum="B68FC248A53C37A3" modified="2022-05-25" version="1" fragment="single">KVNAPAEPQTTTTKTTRKVRKKNKRRKKRRRRGGSEEEKGRRGIKMGKRKTIDEDWEREELAVPLPIQTFLWRQSSPFIRPKLGKLHEATCMSLEKVLVQNILFGLSPSLTDAIKSIPRWRFIQAAVPHVMHCAASLLYNRRESTITNLGAAETKLLYTLHWIILDAAEECADADHEKGINKANTFPYLFSIATIQVFIYLFTPLLHTLKESDFQNFRLENGLKIWTALWEYRHPDVPAFTTPVRPRRQVLRAKKVRRSNTQFGDVFLGGGGISPDDDTLLFLLNGGKSRSITPPPSDPTSSSTLDSRIPDAAKLEEEVRLRLLSGNREATFPETIPEETSSTEEEHVAEHPSSFLRPPTVEISDTTTSPTQPPSVAASTPTESQTPRLNEINSSAKTRTSHRDIGEETGYTIPPRRRSNSLPIPKIHVSLHCDQAEERKPKEGPEQSDQSSSDYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHG9</accession>
    <name>A0A8J5JHG9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 18">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Cdipt-L</name>
        <name evidence="21" type="ORF">Hamer_G008837</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 18"/>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHG9"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000003">
        <property type="entry name" value="CDP-diacylglycerol--inositol 3-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="16 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG7158202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="216" mass="24303" checksum="81C435D58FA02FF2" modified="2022-05-25" version="1">MAENIFLFVPNLIGYGRIILALLSFYYMPTNYIMAAAMYILSGFLDAFDGHAARLLNQGTKFGAMLDMLTDRCGTMCLLVTLSHFYPQYMFLFQLSMTIDISCHWLHLHTTVMAGRSSHKGEEANHNPILRIYYSSRPVLFIMCAGNELFYSALYLLHFTEGPIIAGVGLWRIMSFGLLPVGILKSVLALMQGYNAALSLGEIDVCERQETSQKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHT2</accession>
    <name>A0A8J5JHT2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD40 repeat-containing protein SMU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SMU1-L</name>
        <name evidence="11" type="ORF">Hamer_G010646</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat SMU1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHT2"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000140">
        <property type="entry name" value="SMU1, DNA replication regulator and spliceosomal factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054532">
        <property type="entry name" value="TPL_SMU1_LisH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17814">
        <property type="entry name" value="LisH_TPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="10">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="480"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7153339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="513" mass="57340" checksum="84FA48E6ACCCE7BE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHW1</accession>
    <name>A0A8J5JHW1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Ros-L</name>
        <name evidence="23" type="ORF">Hamer_G012027</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Receptor for basic fibroblast growth factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 25">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHW1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000593">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001227">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF489">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="736"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1096"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1096"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="769"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG7155890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1160" mass="132855" checksum="C28DE478187DD9CC" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JI38</accession>
    <name>A0A8J5JI38_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Endothelial zinc finger protein induced by tumor necrosis factor alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ZNF71-L</name>
        <name evidence="14" type="ORF">Hamer_G011453</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000925">
        <property type="entry name" value="Zinc finger protein 668"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
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            <begin position="94"/>
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        </location>
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            <begin position="237"/>
            <end position="265"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
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            <begin position="738"/>
            <end position="765"/>
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    </feature>
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            <end position="793"/>
        </location>
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            <end position="821"/>
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        <location>
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        </location>
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            <begin position="260"/>
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        </location>
    </feature>
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            <begin position="317"/>
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        </location>
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            <end position="524"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7158777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5JJD5_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </location>
    </feature>
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            <end position="42"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7157068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5JJF9_HOMAM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">Hamer_G011466</name>
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    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7158790.1"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKX6</accession>
    <name>A0A8J5JKX6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043233">
        <property type="protein sequence ID" value="KAG7155019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKX6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="30" mass="3328" checksum="A8526494D2B3D2D4" modified="2022-05-25" version="1">MWLYLWCGVYSCTERGVLGSGSAEFDSNVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLG9</accession>
    <name>A0A8J5JLG9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G019784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036095">
        <property type="protein sequence ID" value="KAG7157919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLG9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="61" mass="6897" checksum="5327A9E8D9838931" modified="2022-05-25" version="1" fragment="single">IHHYEKTGPAAGPSTPVLASRHYTSFTLRTFKFVIFQLIGELVRQLSDQPIRTLLTRADSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JM12</accession>
    <name>A0A8J5JM12_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative CUB domain-containing protein-like 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Cdcp-L11</name>
        <name evidence="6" type="ORF">Hamer_G014861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035946">
        <property type="protein sequence ID" value="KAG7157990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JM12"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035180248" evidence="4">
        <location>
            <begin position="19"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="61"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7157990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="226" mass="25384" checksum="C1F6E638ABE393E4" modified="2022-05-25" version="1" fragment="single">MMITKVLVLMMVMGLSGGVPVDKNISSNTIIGIGVRVDSDLDLDEYHQNRFFFIPFFNIGCGPMKRITLVPGGNTIVKSPRYLLYFSTRTRCQWEISCAPRNTTYLKFDCPTFSLEPSENCVNDRLIVTYKGNRTLYCGDATPDGTITFDGWTRLTFFNRDVVCEEDETTSTLTEPNDEDETAETLTEPSDEGETAETLTESSLAINLAVIFMVDLNEDHNFLFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JM47</accession>
    <name>A0A8J5JM47_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JM47"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="119" mass="13701" checksum="E54D5B18267627E9" modified="2022-05-25" version="1">MKLCLGNSMGLEVDDDDDDDVEELAEEHSKKLSTEELLELHKEENETLKQNLTSEESGEEEDKEESRIIPAKDLKDAFFCWSKLSKLAEDYHPDVGSVQKAISVFNDNVMNYFWKDLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JM74</accession>
    <name>A0A8J5JM74_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor E3-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Tfe3-L2</name>
        <name evidence="10" type="ORF">Hamer_G011293</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MiT/TFE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JM74"/>
    <dbReference type="OrthoDB" id="6242697at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF2">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="89"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7158636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="213" mass="24065" checksum="53A5EB3D920B64E2" modified="2022-05-25" version="1">MTMEDDIVQEILKLEEEMSIDDTPSTSQSSTISPVVFSSQPNICVPGTFSNLGLDTEKPSNSCPPGVPRGTSAASGNSPQVAAFLKDRRRREIHNFFERKRRSNINDRVKELAALLPRRNEPYFEVFRDSRCNTGQILKASADYIRRLKMDVNRSKKMEAERRTLTQENQQLHKRVEALEARLLIRDGDIEVTVTHPDSATSSRQVKDDTTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMF8</accession>
    <name>A0A8J5JMF8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G006431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7159018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMF8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="108" mass="11516" checksum="58B2D8347073D46F" modified="2022-05-25" version="1" fragment="single">GRGARLQPVPESCCTEGVAKELLGALPRAARRSGHVPGGGDVVRLGHQVHPGFSSLLGYVGFPPGLYGIVRLAEYKKKKQEVFEVVVQPYCPPSPPATINNNNIPTNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNC4</accession>
    <name>A0A8J5JNC4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="2">PPIase</shortName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PPIL3-L</name>
        <name evidence="5" type="ORF">Hamer_G007637</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNC4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7160875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="67" mass="7549" checksum="0604C655BBE5C2EA" modified="2022-05-25" version="1" fragment="single">VELFCEHCPKTCENFLALCASNYYDGCLFHRNIKGFMIQTGDPSGTGKGGQSIWGQKFEDEVRDDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNZ6</accession>
    <name>A0A8J5JNZ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028706">
        <property type="protein sequence ID" value="KAG7161927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNZ6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="70" mass="7948" checksum="E058DDAFA1C380DA" modified="2022-05-25" version="1">MYGHGSKARGQPMMSCPHHATMTPDDHITMKTCMKPHLHSHLEGINNTEVKTEVLDRFDNCFANNVMPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPI3</accession>
    <name>A0A8J5JPI3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neuronal pentraxin-2-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Nptx2-L6</name>
        <name evidence="9" type="ORF">Hamer_G021836</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035368">
        <property type="protein sequence ID" value="KAG7158383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPI3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051360">
        <property type="entry name" value="Neuronal_Pentraxin_Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277:SF125">
        <property type="entry name" value="B6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277">
        <property type="entry name" value="PENTRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pentraxin (PTX)" evidence="8">
        <location>
            <begin position="126"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="7">
        <location>
            <begin position="239"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7158383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="374" mass="42735" checksum="3F74A1EC8F67DD16" modified="2022-05-25" version="1" fragment="single">VVTGVDDGRDEGAGVKVFGLQVDTWAAPRDDVMVRYNMCLKITIYTISNCWCGEVLPHTVHYILFWDVNFNNSPTHVSPIQGGVCVAVRKGGTNGLYYNGNKQYGSPTFTTEVSLHQWVHYCHVFSTGHYRAFVNGEERTQGTLYTQDLVLALNSTLILGQEQDLLVGGYDVLQIFRGYISQVNIWDRALGEEEVRDMASCQADLRGNVFSSDKEYVEVLGASVRQQHLNTLCQKLDEYVIFPEMRYLGESQLMCLRVGYEVYGPKTKHSNFALYNESLQFTDSCSSNYHLWLGLTDEEEEGRWRTFLDDSVVQNTSFEVAEPNGKRSENCILMFRPNGLWVDTKCSQVFKKKSRYLFPTIFIRIFCLFIVYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPN8</accession>
    <name>A0A8J5JPN8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate receptor ionotropic, delta-1-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Grid1-L9</name>
        <name evidence="16" type="ORF">Hamer_G007831</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPN8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="82"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7162317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="204" mass="23079" checksum="0DFFFDA49E27DAAA" modified="2022-05-25" version="1" fragment="single">YILRQPLDKKWGTPADDGNWTGIVGDLQHQKADFSLDVTLSESRSTVMDYSRVYQNDPYVILSPKPSSLPRHLSLTRPFEGEVWMSFLVCTSFMGLILWLLQKAWSWASGELGVSLVPTVFHTWGIMLLAPIPTLPTNSTGRVLIGWWLLVCVIVTTGYRSSLIAHLSVQGKYPPINSFQDLLDRDGWSWGSYEFAGTNFLYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ40</accession>
    <name>A0A8J5JQ40_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">THAP domain-containing protein 2-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Thap2-L3</name>
        <name evidence="8" type="ORF">Hamer_G025746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028326">
        <property type="protein sequence ID" value="KAG7162000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQ40"/>
    <dbReference type="OrthoDB" id="6375662at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7162000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="467" mass="52140" checksum="687398E001A3BBD5" modified="2022-05-25" version="1">MPNLCAVFGCNSSGGKKSDIVFHRFPKNEELRRRWIDLCKRQDVFNSNNARICSIHFEPSNFVRNIKYKLLGLPIPRSQRKVRDDAVPTLNMPTSLGNTMISMGKIAHEVREMYLSKFKQVSPYVCNAMSPRVVLLRLNSKMIDKYTRQDSGKNDSLLSDDDEDWFTAVNDNWDMSLLEPIIQISSEANSQQGPKGKREGYARGKRGRLALNINRRKSPVQEEIQVKQERPDSPDLGVPNDTMTILTNVAPYNPAVTMLQVPSAVLPMYVSSSQPSSKTLGKGNINITTDHNALPHTGHPPSYGNGVIETNIKQEVTDTEVIIMPFEAAPHGVRPQDAPSKDTLSSVPSPPPKALNPPNKRKKNSSQGKTKKGTAATSDKDPSGHESLRELTTLLVELNNKNTVCDEKIQLFKDEYEKKVSVIEAEKKSNEKEIECVLSLIQNWKEGSKTKAPAPPTTNKRSRKSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQR9</accession>
    <name>A0A8J5JQR9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027477">
        <property type="protein sequence ID" value="KAG7162662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQR9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="208" mass="24083" checksum="45C729B810607BC9" modified="2022-05-25" version="1">MFHGLVTLGFYGYQFIIESFYLCPLDLPVEKCHNKIYIYEQMFETRVHIGMGEGIACVFFAILYIIALVKHKPSLTWIWLMKSFAVIAINVYYLAAWLIRQGRYDHIEWEKQDYEDEFVFTAEGLTLAQIVIMILFCLIGAIFTYKVRGEDKWAHDATAPPLDHYDEEEAQYLNDALTNSDKTLPARVSKQSLSEISRADTFKHSTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSF4</accession>
    <name>A0A8J5JSF4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="6">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">IDI1-L</name>
        <name evidence="16" type="ORF">Hamer_G002670</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="6"/>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSF4"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="9" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="9" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="15">
        <location>
            <begin position="75"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7163487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="255" mass="29904" checksum="6D7C1A18E2AB98EE" modified="2022-05-25" version="1">MALYRIFEWSLLQTRTRFLHTSSSGLIKQSNFAEDIDPQQYALLDEPCILVDENDTNIGTASKRDCHLMQNGSSLLHRAFSVFLFNKTGELLVHRRSDAKITFPGHYTNTCCSHPLHTPQETIEDNVWGIRHAAQRRLEFELGIPREQAMPGDFTYLTRIHYASPSDGMWGEHEMDYILFLQRDVSVNPNENEVQDVRYVKREDFNIFLKGLRDSNIPITPWFSLIAEKFLPLWWKNLDNLHKFTDHNQIHRMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSW3</accession>
    <name>A0A8J5JSW3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Techylectin-5B-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Tl5b-L5</name>
        <name evidence="2" type="ORF">Hamer_G029284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034571">
        <property type="protein sequence ID" value="KAG7158574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSW3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="227" mass="25669" checksum="D4757036641787E0" modified="2022-05-25" version="1" fragment="single">VDFNRDWHEYKAGFGDLETEFWAGNDFLHVLTNQKTYELHVDMVDFEKGPYWASYKRSWTRSPPNRASKFFTYSCSYGGKPVHKAEVCRTRLQLNTGKPAMIVTEETNTSPVGVMADLSKADSMPIGLVFTKGEVWRVQFRYSPHETLILSRRVLRRTQTLVPFVPFCHKARVVAARKTDKYVVLGSLWGQGVAPLVLVHVKSSCFSGIANVTCVHELPVAGVDLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JT79</accession>
    <name>A0A8J5JT79_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">chs-2-L</name>
        <name evidence="10" type="ORF">Hamer_G011445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
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        <property type="protein sequence ID" value="KAG7158769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF42">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="745"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="776"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="800"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="829"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="862"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="901"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="936"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="964"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1197"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="1258"/>
            <end position="1277"/>
        </location>
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            <begin position="1315"/>
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            <end position="1138"/>
        </location>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7158769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1546" mass="176758" checksum="50F1C9393FA05E0C" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVC7</accession>
    <name>A0A8J5JVC7_HOMAM</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">Hamer_G017326</name>
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        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
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                <person name="Greenwood S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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            <begin position="1"/>
            <end position="16"/>
        </location>
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            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="93" mass="10253" checksum="F3FAF5CB6D265719" modified="2022-05-25" version="1">MQRLLLVCVLPALTLASSLYEYWEAFPEDEGYGPGCVDGKLVYPDIPDDIKANCLGENPPEPLIITNDADCSSYIRCHNGDASPIICCQKEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Greenwood S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWV9</accession>
    <name>A0A8J5JWV9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
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                <person name="Sadowski N."/>
                <person name="Timp W."/>
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                <person name="Greenwood S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="376" mass="39502" checksum="308AC2C38CA83696" modified="2022-05-25" version="1">MRMEVMEVVVATLVVVGGRLCLPRQPSRTWLQEEGRGSPHCPWLIQAIIKLKNNIDKQRLISSLSQNSHSRENINGFSLPASISTSSYVSKPLFPLPEISVSSNFGEVLSGASSLVGGVGNTLTSVGKGASQVLSQVVPAAAAGGIQAARWITDNKKEGIRAATEGLRYAGQLSAAVLRVLLQVPSIKARVLSELLQASQPFAYALSDVLAESADDLGDIFAAKNDILKEALEIFIRLIQDTLALKGRILAKIGASGLDFGASTFNAGLRLGTAAAETSGSVISALSSGVGDLVRVATTADFPPPPAISLPQLPQLPKFSLPSLDFSLLTSYPTLAPLPLPSKPALAPYSLPTKPTLSPTSYKPTSPSQLYGLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXN9</accession>
    <name>A0A8J5JXN9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029517">
        <property type="protein sequence ID" value="KAG7161304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXN9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="54023" checksum="F4029F0B51F998E1" modified="2022-05-25" version="1" fragment="single">VLEPLQTTMILAQLAIGVGLHSSQHHPSTPPLPLTPTELQDLLWPMTARHPPVVPSSDLSHSYTYLSCFVLEGVLCVSSPLFFPPAFSPLAVRKGKGGDSVDVSLREDHGEATQVNVVESRSVTDELRLLESQIKLKEAEAIARRAVIRQAEAEAKAKEVGIRNLVLLKRLLSMLMDMRSWTRSPPNRASKFSTYPCSYCGKPGHKAEVCWTRLQLNTGKPAMIVTEETSTSPVGVMADLSKADSMPIGLVFTKGEVRVSAVSVLASRDFDLFQESFAKDPDVGTFLSQGTVEVDGVETPVTILRDLGCLQTLIKESVVAARKTGKYVVLGSLWGQGVAPLVSVRVKSSCFSGIANVACVHEMLVAGVDLILGNDLAGGQMGNVTPPPVLREKPESTAELQQLEDDMPGVSLLCAVTRSMSMTNDHNVTPVVDDSLSLEGLFANPIASQDISSAVNAVTGRVALIAAQEQDDSLRLLFDSGHTTRYFSQDGVLCRRWLPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYR2</accession>
    <name>A0A8J5JYR2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="3">2.4.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GBE1-L</name>
        <name evidence="9" type="ORF">Hamer_G011973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7166036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYR2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="8">
        <location>
            <begin position="213"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7166036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="663" mass="75812" checksum="E2B4613C0B836A45" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYV7</accession>
    <name>A0A8J5JYV7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MRPL3-L</name>
        <name evidence="2" type="ORF">Hamer_G014292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025553">
        <property type="protein sequence ID" value="KAG7164159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYV7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="263" mass="29515" checksum="1775D00024B42636" modified="2022-05-25" version="1">MAVLYRLKSAIHGRHMTSLTVLCQKLPVPIQPLAFATQIRNMSRVKRRHSQPPFWLPKTTRTMYPEELTPENESYVSEVIADQYSSPLKSDPWERGAWHEKSIRCGVIARKIGIYPMWTKNGTRLLTTLLQVTDNHVIKYIPPEDLMETEKKANRLRPTAALIVGADAADPRMVTKEFFSLFSETGILPKKKLSKFLITPNAKLAPGTPLYASHFRPGNYVDVAGVTATTNTLDLTPHPTATLHNTPKPELVRCMGVCNLEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZV0</accession>
    <name>A0A8J5JZV0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein (VmcF)-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G013129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024020">
        <property type="protein sequence ID" value="KAG7165626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZV0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="209" mass="22096" checksum="A2C38F78441ADD11" modified="2022-05-25" version="1" fragment="single">MAGSATPVTAMKVTRFCDAEMESMEWMLSTQTFNPQCTNHPLYTSKQNTAFRQLVKTSVKPQPSTSEPQPSTSDPQPSTSGEQQLSVQIDSNNESEVADDPGSDDESEVADDPGLMMRSEVADDPGSDDESEVADDPGSDDESEVADDLGSDDESEVADDLGSDDESEVADDPGSDDESEVADDPGSEESEVANDPGSDDESEVADDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0C9</accession>
    <name>A0A8J5K0C9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027321">
        <property type="protein sequence ID" value="KAG7162714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0C9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="89" mass="10361" checksum="615568EF22163C0A" modified="2022-05-25" version="1" fragment="single">MVVCEAARQTKPLLHTLGNHFWTSELTCCRSMASQKTIKNFFKPVIKRKSEDLEAEIKQQCKKTPGLHENIGHSWYMALKSQFSQPYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2U5</accession>
    <name>A0A8J5K2U5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pro-resilin-like 96</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G016814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020459">
        <property type="protein sequence ID" value="KAG7168181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2U5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7168181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="132" mass="14427" checksum="784C20A2326BCEA4" modified="2022-05-25" version="1" fragment="single">VVVAAVMVGLVVAAPQYDYEPPQAPSSLYETPAESVQEPVQLYEAPSNNVLIAQPQNLVPDVVSPPQMEGMPYDFQWGVEDQDSGNAFSHVENSDGSTTQGEYRVLMPDGRTQVVRFFDNGGGFNAEVTYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3W6</accession>
    <name>A0A8J5K3W6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G013627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022272">
        <property type="protein sequence ID" value="KAG7166615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3W6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="159" mass="17694" checksum="68EAFEE3216905F4" modified="2022-05-25" version="1">MHFPEVTTAFLSLASTPSELPDGVLSTLKRFIMLLYDHTSTCCDVNVLRKKLFSRKSRSLEHLPPTRAALEQHIKRAVYQAGHIWGQAAIAFVSLPSPYDWGWMKSGDELEPLWTTLSEVSKSCYEFISCGCKKHCSGKCRYKKAALKCTGLSACEGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K461</accession>
    <name>A0A8J5K461_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Tigger transposable element-derived protein 1-like 321</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TIGD1-L321</name>
        <name evidence="3" type="ORF">Hamer_G011589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K461"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035210552" evidence="2">
        <location>
            <begin position="29"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7168912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="504" mass="56529" checksum="BC0A584F08F27B1C" modified="2022-05-25" version="1" fragment="single">MKGRPRWGLPTMLLDLANWLEWWCYIQACGDVLEVLIEAMQAGKWKASQKELKQLVLPSTTEEIMRLLHDDVVYQGMNITTRLKSLEVDQDIFEYCRDCHRWNTMMAMIRDDAGCRWGTHVLTVVKSSEAGVDTQGSNEDLDPVTDSSSSSCEEESQGDLQSVKERSFCGENTQICLSYLSRQSKLSNVVSKGTVVFVASVYDLSSCEMNPYTDCGASVVVQRHNKTILSDNCDGFFSRVHYGQKLVHCQDHLIPVLNRAKALPEEDFEDLQSADIINLVEAPEQELSNSNVLQLTDWSPNDPGLEEEDEEHVEPSPTLSMPNLAKILTLHQQLIDLIYEADPSFEREETLTSNLTRDIVPYKEIYWEHLATIKQPMIMTFFQSFSASPTSVLLPATQQQKEQQEPTPGPSGVTHAHASTPTVSDSDSDPDSPPSPPSPTPNEADTHTYNDDNDAPSMDVDVDSSLNDELDLFIVRQLDHNSQIYLHPLCPPTSADCRCWKPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4Y0</accession>
    <name>A0A8J5K4Y0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G005446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4Y0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="114" mass="13322" checksum="BEADBAC1E8755655" modified="2022-05-25" version="1">MAVGLRAKLYRLPAIYMIIMFQCLLSTTDGLHKFLQRETVDFAQALQFNYAAYDTLREKCTDEMAEDLYKKAKAISKTKHIQDRGVQDANKRRWSSMWWRPLVDQAPISATQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K599</accession>
    <name>A0A8J5K599_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G013321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015640">
        <property type="protein sequence ID" value="KAG7169696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K599"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="191" mass="22200" checksum="245DCBEEE0C73F81" modified="2022-05-25" version="1" fragment="single">MVGVGKRGVVGVLGVSWFFFLLFLLYHHHYNTPTTRVFLVSDDNSSSRWTEQQVEDEVEGLKKVQKGVTEETLVMIGMKGVQEKGEEEKGGVLPQKDVKKEIQKEQKIKEEILLKQEEVRKEVLEYENVREGTLEQKDVRKEIQEREDVLKKIREQKDVKDEWRVKLGNSTSNVSAVGLGHQEKDYLHYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5Q7</accession>
    <name>A0A8J5K5Q7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016767</name>
        <name evidence="3" type="ORF">Hamer_G016768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020459">
        <property type="protein sequence ID" value="KAG7168137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010020459">
        <property type="protein sequence ID" value="KAG7168138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5Q7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7168138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="9716" checksum="55656811415E5275" modified="2022-05-25" version="1">MVKPQDQLVHPNHVLDKLMVRIRTHSTNSTNSIYSSSSEISCSGNSYTSQEQDAKPSSPKKTKKLHKKKKHHDVYLTNSLLSYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K691</accession>
    <name>A0A8J5K691_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K691"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12171" checksum="2925960B8B63425D" modified="2022-05-25" version="1">MGDILVDNQVTTTTTTTTTTTTTTTTTGVRVKAKMTETGLAVGITFIVIGSLMTAYGIFACATSKGSVYNAEDVDAMVTATVMEEEKQRKKDEALFDDFKPGEKTKKRKVLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6J3</accession>
    <name>A0A8J5K6J3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Attractin-like protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Atrnl1-L</name>
        <name evidence="7" type="ORF">Hamer_G002591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6J3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000008">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF2">
        <property type="entry name" value="DISTRACTED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="84"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7168509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="810" mass="90378" checksum="DB9431D88DD540B1" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6L6</accession>
    <name>A0A8J5K6L6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019217">
        <property type="protein sequence ID" value="KAG7168746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6L6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="165" mass="18188" checksum="32E190193F9E1B57" modified="2022-05-25" version="1">MKDSPTPSPPPRTPLHPHPHQGLPYTLTPTKDSPTPSPPTPLHPHPHNGLSHTLTPTKDSPHPSPPPRTPHTLTPAKGLPYTPHPYKGLPYTSLPTKDSHTPHPHHDSLLTPHPYLGMTQVTKGDKRSLPADERHLYGVGFAVKSKLPRHTPEPPTDVSERLMTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K814</accession>
    <name>A0A8J5K814_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cc8K15.2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018240">
        <property type="protein sequence ID" value="KAG7169139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K814"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="769" mass="87517" checksum="CA1E0B35FB152306" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KAC5</accession>
    <name>A0A8J5KAC5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein Abitram</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-binding transcription modulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ABITRAM-L</name>
        <name evidence="7" type="ORF">Hamer_G011732</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABITRAM family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7169033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KAC5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032433">
        <property type="term" value="C:filopodium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051489">
        <property type="term" value="P:regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039169">
        <property type="entry name" value="Abitram"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651:SF0">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7169033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="231" mass="25602" checksum="02E08A52C607D405" modified="2022-05-25" version="1">MHPDLSPHLHTDECNALISKLQNCHKENKLLKFVGICNEIDTAVWKCLKAEEKKKVENASGNNVLACEVDQDTASEQSGNESTALKENNRRSYPQNNENSSAREERVSSQPDNSGHTCVMISYDVGKFNRLDNQVSGKGKRGAQLMGLQSPVCIISCVDGTKYTVLAGVQGKLVEVNERLLSYPQLVSDHPDAEGYLAVVLPPLRNGDFMRSKLFTEEQYKELDHYGISGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KBS7</accession>
    <name>A0A8J5KBS7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KBS7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="77" mass="8849" checksum="533EB9F48A14C2AA" modified="2022-05-25" version="1">MGRRPAQRRYRSNSGGHLRNHRPMTVIHGNNHRTPLLYKQPYTQSHSHIPSSSHEPPPGSVFLTLLVLYLQCIPEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KE16</accession>
    <name>A0A8J5KE16_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Ammonium transporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Amt-L</name>
        <name evidence="1" type="ORF">Hamer_G013511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KE16"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7170688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="69" mass="7886" checksum="213636CA91B209E7" modified="2022-05-25" version="1" fragment="single">MSATFVILYIINRFIVNIRMSEWEELVGADFAEHAIRRRNVGVSRAVSVLGFHHHGYDYSDIPPQGDNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KKD0</accession>
    <name>A0A8J5KKD0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AT-rich interactive domain-containing protein 4B-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Arid4b-L3</name>
        <name evidence="3" type="ORF">Hamer_G013716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012455">
        <property type="protein sequence ID" value="KAG7171265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor-knot" evidence="2">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7171265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1334" mass="148169" checksum="11CE353FE9F00BD8" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KRF2</accession>
    <name>A0A8J5KRF2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phenoloxidase-activating factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PPAF1-L</name>
        <name evidence="6" type="ORF">Hamer_G018559</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012106">
        <property type="protein sequence ID" value="KAG7171444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KRF2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="248"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7171444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="432" mass="48100" checksum="6BC32DFA350B8AB4" modified="2022-05-25" version="1">MNILFQVVVVNVLTRSHCLPKNGVTVENDVTVFLHRGDVTGALCWGRIPLLRDSAEQLGIHENESSIWDSVEVAQLDGFVILVIRPVGPAHDFNVSIPEVHLSQLRDSLNSSVVTEEIDEYTQTMSTSWDIIGPGYLDDVVPPLQVGSVGSGVSDILRHVASRSLPVKCGFYTLSPRNPLSIQTPRFPRPYPHNNRCTWKLQNTVNEQIFFFLRYYGRNGPTNDIFRDTSVKLFFKSNYKKSSLGFLCLLVDLLRARLGMLKRTTKNPEVTMTAVDIVLYPTYTFADDLALIKLSDAISITNTVRPICIPDITFKSESFQGKTLKVAGWGKTENGKLSDSLRKLERDGMDAAKCKLVFGSYITEHHFCTTGPGVKHICLGDSGGPVMMLKGQRFVLVGVISFVASLNCKGNYPDGHVSVAHFRDWIRKVTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJ96</accession>
    <name>A0A8J5MJ96_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">T-cell immunomodulatory protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ITFG1-L</name>
        <name evidence="9" type="ORF">Hamer_G019563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046868">
        <property type="protein sequence ID" value="KAG7153499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJ96"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="8">
        <location>
            <begin position="381"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7153499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="533" mass="58989" checksum="776E944BE6D31F9F" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJH9</accession>
    <name>A0A8J5MJH9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD repeat and SOCS box-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Wsb1-L</name>
        <name evidence="4" type="ORF">Hamer_G019585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046868">
        <property type="protein sequence ID" value="KAG7153517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJH9"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03587">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051983">
        <property type="entry name" value="WSB_SOCS-box_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15622:SF2">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15622">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="161"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="3">
        <location>
            <begin position="379"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7153517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="423" mass="46899" checksum="DEAAF6234EF89019" modified="2022-05-25" version="1">MAPERVLRDLLRVSGEARVIGELITGRDGNNYAPGGESWKCAFAPDESRFAWSCGFRKVVILPWNRYKNCLLGHRHRGQSDRNNTNGEGYEVFAEKINIDAGFPVTSLAFGTGTPEQELVPVKREYWTRFNFSKDLILATGHNNGRIRIWDPYTGKLLLELTDHMKPVTDLAFAPDGSLRLVSASKDCTIKVWDMSDDGNMFKTLKEHPGPIRSLCWSPDGRYLCSAGDKQKVLLWDMNSYSLSKRFCGHYNNVLSCAFSPDGAMLATASCDTRVIIWDTSSGEQLRVLNHMNPPPGVIYMSGENNSVVRGVGFSPNGCHVVTICCDGFIRFWNLMYEEDGPESVGSALPGDAMLNCSFSPVGGAVSVGHASGSVVFFLAPTMVPSLLHLSRMSVRRSLGDITARDDVVLPHTLKPYLQYKQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK35</accession>
    <name>A0A8J5MK35_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045135">
        <property type="protein sequence ID" value="KAG7154130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MK35"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="69" mass="7707" checksum="DA3110683FDCBF07" modified="2022-05-25" version="1">MEEYKALYTSRVNAHQQAHITRYLRKAQPDNALENIALGDDDDDDDDGTTDDDIEVLGDLLVEGATSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ML03</accession>
    <name>A0A8J5ML03_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U-scoloptoxin(01)-Cw1a-like 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G015699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043233">
        <property type="protein sequence ID" value="KAG7155092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ML03"/>
    <dbReference type="OrthoDB" id="6340602at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035194871" evidence="1">
        <location>
            <begin position="18"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="48"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7155092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="135" mass="15009" checksum="24227F5D5A487ACA" modified="2022-05-25" version="1">MKVLYLGVCVMLGCVAALPGLRLRRDSSVFSLELPSNASLTIGPIQTGFDCSDLPYGYYADEANNCAIFHVCLPYIDHGVYVSRHFSFMCGQGTVFDQERLICDFPETALPCSQVAAFRNTNEYFGRADINFLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMU8</accession>
    <name>A0A8J5MMU8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase KEG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">KEG-L</name>
        <name evidence="7" type="ORF">Hamer_G027137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037618">
        <property type="protein sequence ID" value="KAG7157266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMU8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052667">
        <property type="entry name" value="E3_ubiquitin-ligase_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47156:SF10">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM-21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47156">
        <property type="entry name" value="PROTEIN CBG20824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7157266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="277" mass="30976" checksum="C41FDD5001C7BABF" modified="2022-05-25" version="1" fragment="single">SQDNDKPEECKVCFDNFDEALRRPCSLPCGHTFCTVCIVDMIKNSQFTCPTCRADHNTLALTDVTQLPINYGMESFIRRLKGVSLKPAQTKAPTKPPQDGPRGISKKLRSLLQEEMNKVISLITACDEKLSQLGKYGKKVKGLKTGHNLLEDRLNGLLEQNKAAKELVEQEETSVEDMSTEGEEEKQQLQAVLECLNTVNSLQEFHTAIEDADRRSVVTEDWIHKCQEQFSKREHCPHLSEGAGEHQVGPGHDTHRGCCHSCPPPPGRLSLHHLGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNM7</accession>
    <name>A0A8J5MNM7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G008751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNM7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="154" mass="17399" checksum="F91882A1079702B2" modified="2022-05-25" version="1">MTREDLEELMQDGNTNDVEDLLEDEEGGESGDAASDAGETEQRKVTTQKLSLLLGVCTSLQEMIQDIEIDSGEREQMIGFVKSISRKYQKQYNERVNAQQHSLITHFFSQSRPAEEDQQTEVEVDEDIDDIGEMPEDFDFAGFDEVLAEVGEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPC9</accession>
    <name>A0A8J5MPC9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C-type lectin-like 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Clec-L22</name>
        <name evidence="2" type="ORF">Hamer_G006265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPC9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="165"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="293" mass="32950" checksum="4179C7F40281CC1A" modified="2022-05-25" version="1">MTCGSPYTLVGNECLYFMVFAKVTFQEAHYTCQTADGGLANIISATQMKAVVDYIKFSDFKSKDFWLDGTDSEEEGKWTTVSGQPILMGTPFWASYLAHDEPNDYLHKEDCLVLSYDEFYYMNDVSCDDKSHPLCQAPPTLTAEDEGAATALSGSLECPFMFNPVGGLCLAFVLWEKLSWTDARQICHGMNGDLVAITDIEVLRALYMHLQDENIADHTFWVGGSDAEEGDWRWTTNEAVDMGTPFWGLYKYQQEPTAGIFGNCLTLKSPGGYYFRDDSCHEKHNPLCMYVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQA5</accession>
    <name>A0A8J5MQA5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Visual pigment-like receptor peropsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RRH-L</name>
        <name evidence="12" type="ORF">Hamer_G022415</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032177">
        <property type="protein sequence ID" value="KAG7159801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQA5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="105"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7159801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="268" mass="30268" checksum="393B1F93D3C629C4" modified="2022-05-25" version="1" fragment="single">NPLAEVNPPAEVNPLAEVNPLLKLTLAEVNPLAEVNPPAEVNPLAEEMGEDVFSPEQQMALLNASGHEPRLWEPVSPNQHTYIGIYLIVVGVLGTFDNALVVAMWLYGDFGCQYYAFMGFLMGIANLTTLLMIALDRYLVTCRHDLRGKMTYKTYYQMIAFIWLWSLFWSVCPLLSWASYGYEPSVTTCTINWQQNDASYKWYIMTMGVVLVVAYLFCWSAYAVCVTVFRHPYTVPLILTLLPPLLAKVSPVLNPIIYFLPPTPEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQE5</accession>
    <name>A0A8J5MQE5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Furry-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FRYL-L2</name>
        <name evidence="3" type="ORF">Hamer_G026788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031758">
        <property type="protein sequence ID" value="KAG7159890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQE5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="106"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="996" mass="112510" checksum="EDFCD5E1011A6DC2" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQS3</accession>
    <name>A0A8J5MQS3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQS3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="72" mass="8575" checksum="D42D9A28E69FA198" modified="2022-05-25" version="1">MHCFRRQMGRHTERTAILRVLRMIHELPFDIDMSAHWTGYNSLLPSYTPVHTHNVLRCRAQRYGRFYDVGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRN2</accession>
    <name>A0A8J5MRN2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029263">
        <property type="protein sequence ID" value="KAG7161483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRN2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="130" mass="14601" checksum="6C00503FE3C9A213" modified="2022-05-25" version="1">MTLGVKWNPQDDATYKGELQLSSPLPERSRPQSLPDKPRPHITHSGQAMPTSFTSDKPRPHYPLLTSHAQIPPLPEKPRPQPMVDKPRPHITHHPCRRNLAHTQPLPVNPGPYNTPAIQATPAHHPCHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTA5</accession>
    <name>A0A8J5MTA5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pro-resilin-like 171</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G027601</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027611">
        <property type="protein sequence ID" value="KAG7162606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTA5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7162606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="204" mass="22378" checksum="8B5416E32CB09DEC" modified="2022-05-25" version="1">MDVIKLLMYDLFSGLLSKLLNGGQVPWSLTGSRSLLLSLLHLASRQDGLSLRYINLARPSVDTSLVLPSHLNMVLKVFVIAVLVAVTIADTIPYTPPHPSYNAPAPTGPAQYNFDWSVNDANSGNDYGHNEGRNGYDTQGSYYVQLPDGRLQRVTYTVNGDSGYVAQVEYEGEAQYSAYQPAPSYQPAPPYRPAPTYTPTPSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVH2</accession>
    <name>A0A8J5MVH2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dihydropyrimidinase</fullName>
            <ecNumber evidence="6">3.5.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Dpys-L</name>
        <name evidence="10" type="ORF">Hamer_G017309</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16121"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="EC" id="3.5.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="6"/>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVH2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006208">
        <property type="term" value="P:pyrimidine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000076">
        <property type="entry name" value="Dihydropyrimidinase like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="56"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="522"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7164902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="569" mass="62282" checksum="48B5E386C1542952" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW74</accession>
    <name>A0A8J5MW74_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW74"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="269" mass="31440" checksum="58212B48AB332AEC" modified="2022-05-25" version="1">MEQLFSKCSNQHFEEYAQEVFIPYMSTKLQTASRLDLVLDRVDSNKTELFKFLSDALLTWFDKEDKQLVITRDRQSLASQCSLIWHRSPHAIKEKQTVACCCMHPMHPSMATIRYWSGLWTQMSWFWLSRWSKGCTKKMNCGWHLALARVSAFFQPTKWQHVWDQRRRGHCLCATVSSFSGHGKMTAWVIWAVYPDLTEALLKLSAALKVLPEDVMHIIERFVILLYDRTSSCMDIKKARRKLFAKNNIVQLIPLTKAALEEHVKRAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2022-10-12" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWQ2</accession>
    <name>A0A8J5MWQ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G010318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="12" mass="1165" checksum="DBF87273F7B6876D" modified="2022-05-25" version="1">MVASAPMCVSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXG4</accession>
    <name>A0A8J5MXG4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box/LRR-repeat protein 4-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Fbxl4-L5</name>
        <name evidence="3" type="ORF">Hamer_G023963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022339">
        <property type="protein sequence ID" value="KAG7166594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXG4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22117">
        <property type="entry name" value="F-box_FBXL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008485">
        <property type="entry name" value="JAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF152">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05571">
        <property type="entry name" value="JAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="274"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="636" mass="72137" checksum="02768880526BAB86" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXL2</accession>
    <name>A0A8J5MXL2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Bscl2-L</name>
        <name evidence="9" type="ORF">Hamer_G010399</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXL2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7166744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="167" mass="19170" checksum="BCC13215E8C2975B" modified="2022-05-25" version="1" fragment="single">NMQSTAYSLVVFTATMVVMFWASVFLYTSFYFTYMPDESVMWPVHFQYRSCHDKPGICSNPFAVISVTDPTRGSLLARGQKYRVVVDIDMPESPTNQKIGMFLINMNMKSHTGEVLREASRSSMLRYKSSLLQTLSTITFAPLLLYGIHEEKQMVTVELFSQYEEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY48</accession>
    <name>A0A8J5MY48_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Ugt2B16-L</name>
        <name evidence="6" type="ORF">Hamer_G010107</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY48"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7167722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="400" mass="46136" checksum="6324CDE28ADD435E" modified="2022-05-25" version="1">MWSNEAIQRLWQNRDSYQAIVIIGYINEVAVPFLLDYKGVYINLCTPGVELLHMKQQGNWLPMSVLPGIKTTFTHDMTFMERVLNPLLTLWPYLNYQYNVIPRFQELLQKFFPNLPPLTTLYWNSSLTLINSHYAVDGPMPLLPTQVEVGTINAKKANPLPQDLEEFMEGAGEAGVIVFSLGSVVKSGEIPHSYKMILVEAFRRLPQRVLWRYEDDDLDLPANVLTMKWLPQQDVLGHRRTRVFISHCGTFGTQEALYHGVPVLALPIAHDQPRNAQRFAKKGYAYLLNWKDLSVNAILNGVKTLIKDPTYRERVKDVSRMLQDQKESAGERAVWWVEHAIRHQGSPLLVYAGKRLNFFQYIMLDVFVFWLVVLSAWAFLSCYCVRRLSGLCCSRKDKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYB6</accession>
    <name>A0A8J5MYB6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G002396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYB6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="116" mass="13472" checksum="695E7833E28BAF80" modified="2022-05-25" version="1">MKDHKLEEYKDKLQGLLDNFLTRFDDLQQLKPCFAFLVNPFKVDVINVGCLILSPLATDSSAVKMELIEFQEDLGLKRIHKSQSSVELWKQVPETKYPELKKTSVTHLNFQHNILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZY2</accession>
    <name>A0A8J5MZY2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Neuropeptide F receptor-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NPFR-L2</name>
        <name evidence="13" type="ORF">Hamer_G013250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015640">
        <property type="protein sequence ID" value="KAG7169641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZY2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF12">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="106"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="399"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7169641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="442" mass="49944" checksum="5F8D1FCABB47BF7D" modified="2022-05-25" version="1">MENISLFSEPELCSGVMCPLQPDEYKALEGHVMSGTTIGEEDNPFTNQLESFFKSSVLPTGANQSLPWEEIMKILKETNQKSYLGTAAKVSLITIYSLLITVGILGNLIVAFVIGHRPELRTARNVYIINLAVSDVSMCLVCMPFTLVGLLHKNWSLGNFICKLVPVVQCTNILVSTATIVAIAADRYLTIVCVQRNRDARAYIPWSVAAIWLVSLVFPLPLFAYYFVEKVQIKDYLLYEKCVESWSSPVVKYTWNITLIVMQYIIPILVLSFVHGRIQNYLSSHKMSQRDARRAQREIERNRRTTILLTSIAVTFAICWLPWHVVNLLADFNYAGFQEPEYFYVVFGSCHAVAMSSACINPILYGWLNTNLRKEMTQAIPILLRKSVSLLVHRPLRDDSCPGKDVPEEGGSKKNHHQTKTPFLKTESAKIGEVTDQNHDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N097</accession>
    <name>A0A8J5N097_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G012202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7169986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N097"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="90" mass="10061" checksum="F0FFB3E112EEC6BF" modified="2022-05-25" version="1">MNLLSNTYNLSSASSGNGDSILITAMTYSHLVAMKYHNGGKQCKLADWCYGGVMRETLPMCLLKLHTKMHHCFSLLLYTPCEGKVFLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N152</accession>
    <name>A0A8J5N152_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G012551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N152"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7170977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="58" mass="6403" checksum="4497DA3FB1B36BB0" modified="2022-05-25" version="1">MPVTTVLLGEDHPLVLPAEEWVDYIEVEEQVLHQWLEVDEAVNSSASACTVCAHSRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1C5</accession>
    <name>A0A8J5N1C5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">5'-nucleotidase</fullName>
            <ecNumber evidence="3 9">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nt5c3-L</name>
        <name evidence="10" type="ORF">Hamer_G012519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the pyrimidine 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3 9"/>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1C5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.340:FF:000001">
        <property type="entry name" value="Cytosolic 5-nucleotidase 3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.340">
        <property type="entry name" value="Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006434">
        <property type="entry name" value="Pyrimidine_nucleotidase_eu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01544">
        <property type="entry name" value="HAD-SF-IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045:SF0">
        <property type="entry name" value="7-METHYLGUANOSINE PHOSPHATE-SPECIFIC 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05822">
        <property type="entry name" value="UMPH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01128">
        <property type="entry name" value="C1.4:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7170946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="373" mass="41980" checksum="BBC3253D3C226D45" modified="2022-05-25" version="1">MISSRGTVLRAGGRQLTRVLGGSRPLELNIDLHNKVNCVRTKATESSDSALSCAPPSFMPETRTMYPTLEKLGLLSATHIRIQDMARAEELVTTIVGSGFSKLQIIADYDMTLTRSHVNGERAETSFGIMDNSAQMPAFYREEANKLLAKYYPIEIHPKMTEEEKIPYMIEWYEQIHKLIVKCQVSQESLKGMVSSSNARLRDGTEDLFSKLHSTNVPVLVFSAGMGDILEQVLRHFNVYTDNVKVVSNFFKYNEEGVMVGFKGELVHVFNKNENAIHSSNYFNKLKGRNNVILMGDSLGDIKMAMGVPQPSNVLRIGFLNDKVREVLKHCLLLNLMFIVQEERLEAYMNNFDIVLIDDQTMDVAGSIVGLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2M5</accession>
    <name>A0A8J5N2M5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein 19-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Rbm19-L2</name>
        <name evidence="4" type="ORF">Hamer_G001004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2M5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7172028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="119" mass="13542" checksum="CEC071A41E84AC54" modified="2022-05-25" version="1">MHDAGKQTSSKMVVKNVPFQATVKEIRQLFETFGELKSARLPSKPGNVEHRGFGFIEFVSKEDAKKAFEALGSSTHLYGRRLVLEWAKEEESVEQLRKKTAEHFLAAGNEIKKHTYIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2W3</accession>
    <name>A0A8J5N2W3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adhesion G-protein coupled receptor G4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Adgrg4-L</name>
        <name evidence="10" type="ORF">Hamer_G009610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053066">
        <property type="entry name" value="ADGR_G7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767:SF1">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035212171" evidence="7">
        <location>
            <begin position="39"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1266"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1301"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1331"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1368"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1418"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1461"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1489"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="8">
        <location>
            <begin position="1084"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="1264"/>
            <end position="1512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7172255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1597" mass="180885" checksum="1F12EBF865375512" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4K1</accession>
    <name>A0A8J5N4K1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010116">
        <property type="protein sequence ID" value="KAG7173287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4K1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="8087" checksum="BFB91E7C3D2244A6" modified="2022-05-25" version="1">MTISTNYNSGIVSRQPSYTNDNSRIKLVDPDSTNEILELRKSKATKKSTNENSGYERKVSEKSSEKDRFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N598</accession>
    <name>A0A8J5N598_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009370">
        <property type="protein sequence ID" value="KAG7173587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N598"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="163" mass="17829" checksum="FD24D798B13D9262" modified="2022-05-25" version="1">MEDPLTSEEVLEMAKKHAEEEEATDKPQTVGKELTIPKLREFMQHVTCATHSALQHDPDMECSMQVMEVLNRAASTYSQLLDQMVMAQQQKKITSFFCSLSSPVEFVMKLTPGVAGPSTSGQPRPSTSASRVSDASTVTALDSDVDDELVEFGSTSSEDELPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6Z0</accession>
    <name>A0A8J5N6Z0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="9">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lipoate synthase</fullName>
            <shortName evidence="9">LS</shortName>
            <shortName evidence="9">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Hamer_G023349</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010006876">
        <property type="protein sequence ID" value="KAG7174800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6Z0"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="143"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7174800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="401" mass="44856" checksum="3DC739CD6DDE37F8" modified="2022-05-25" version="1">MAARLRLLPGFTHHLVQWCQAMSWQNVRLCKVLAPTQMGITRQTSSLPNGKKEKVAEGPSLEDFISGEVTKDMTWSDYTGKLKRGKGETDRLRLPPWLKREIPLGKNYNKLKADLRGLNLHTVCEEARCPNIGECWGGNEDNVATATIMYCVSQLMGDTCTRGCRFCSVKTARKPPPLDPEEPVNTATAIAKWGLNYVVLTSVDRDDIPDGGSSHFAETVNELKRQNSSILVECLVPDFRGDKDCVATISNSNLDVFAHNIETVEALTPRVRDPRAKYRQSMGVLEHAKTVKADLVTKSSIMLGLGETDDEILQTMKDLRTAGVECVTLGQYMQPTKRHLRVTEYVTPDKYQHWEEVGKSLGFVYTASGPLVRSSYKAGEFFLKNLLTQRKQEKSLKVSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7J9</accession>
    <name>A0A8J5N7J9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase 25 family member-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Glt25-L</name>
        <name evidence="6" type="ORF">Hamer_G015776</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007499">
        <property type="protein sequence ID" value="KAG7174641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7J9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050211">
        <property type="term" value="F:procollagen galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035229474" evidence="4">
        <location>
            <begin position="26"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="5">
        <location>
            <begin position="328"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7174641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="541" mass="63230" checksum="E5A7A880D4214F92" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N926</accession>
    <name>A0A8J5N926_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
            <ecNumber evidence="10">6.1.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glutamate--tRNA(Gln) ligase EARS2, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">EARS2-L</name>
        <name evidence="19" type="ORF">Hamer_G008993</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Gln) + L-glutamate + ATP = L-glutamyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:64612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:64613"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:23541"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Glx) + L-glutamate + ATP = L-glutamyl-tRNA(Glx) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9713"/>
            <dbReference type="Rhea" id="RHEA-COMP:9716"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:18398"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EC" id="6.1.1.24" evidence="10"/>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N926"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050561">
        <property type="term" value="F:glutamate-tRNA(Gln) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 17 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="18">
        <location>
            <begin position="37"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG7176226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="390" mass="45309" checksum="17B5A1B40C8FBEDB" modified="2022-05-25" version="1">MAQLFTHLQRIPLLPCKVQEARKFMRLFSISAQKACQVRVRFAPSPTGHLHLGGLRTALYNFLFAKSKNGKFILRIEDTDQTRLVVHAAQRLEDMLKWAKIYPDESPTVGGPRGPYVQSQRINLYHNYMKNLLENDSAYKCFCSKLRLDWLRNDAIRRNETPKYDNKCRYLSQVKIEELERKGTPYCIRFKLETITDPYQDLIYGPILINVAEHEGDPVMMKADGYPTYHFANVVDDHLMGITHVLRGVEWQISTPKHLLLYKAFGWNPPLFGHLPLIVNRDGSKLSKRQDDLHIEHYRDQGYSPEAVLNFVTDIGGGFEGKEHNVLLTIEELSEKFNLARLTKNSCRLDFDKLKLYNQMDLQRCLKSPTELPVLLDQLQDLVKKTFEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAW9</accession>
    <name>A0A8J5NAW9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TELO2-interacting protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TTI1-L</name>
        <name evidence="3" type="ORF">Hamer_G020964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004117">
        <property type="protein sequence ID" value="KAG7176119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAW9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24176">
        <property type="entry name" value="TPR_TTI1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="2">
        <location>
            <begin position="825"/>
            <end position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7176119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1142" mass="128666" checksum="5E1E94189033304F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBF5</accession>
    <name>A0A8J5NBF5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Juvenile hormone acid O-methyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">jhamt-L</name>
        <name evidence="4" type="ORF">Hamer_G015361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBF5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7176562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="244" mass="27822" checksum="2461A2895B1282E9" modified="2022-05-25" version="1">MEDAQLYVSANALQRRDALVVLTEYLPQMVWQEEGEAVLDVGCGSGDVTRNLLMPLLPRVEQVVGVDVSTEMVNFASKTFQHNSLSFQHLDIERGVQPRNIFQLLQPGGEALLVFLARNPLFTVYQNMSEKTQWQPYMQDVTSFISVYQHKTDPAQAMMDAAEDVGFEIVSCEAPQFEFVFENINYLRNAIKAVNPFLKRIPRQQQDTFLMECLSELAKLKTQAEDGKTVARYNLMIAHLQRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCH1</accession>
    <name>A0A8J5NCH1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCH1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35867" checksum="6AFDF69B9EDCB5A2" modified="2022-05-25" version="1">MEPDAANDMNFEYFDTTDRDSYTTAGMTDSHAYDSEITINTRGSFNGPDTDNLFHTGGHSLEYQEAHRRAQLNTASSTALTIVQSPEQVHPQALGRDPDYVEMSMGRPGLDKGLLTTEDSDEDLYRVVRPCEVFNSSHSEVLLQGHSEVPPPPPELSRASTINWVTSFSQPSRRPNPSKKRSDTLCQPSIATSQAPPPPIQLSEVASQLSNGCEYHQRSRNLNNLSSREYRRRRSLSRQHTKQRAHQLQQENHVLQVKAEGLKRLRDDMKRYWDIYVKPSTCSNSVTACSSTMNDFNCNTDTTACTPIPQPVHRYHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCI1</accession>
    <name>A0A8J5NCI1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Txn2-L1</name>
        <name evidence="3" type="ORF">Hamer_G000279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCI1"/>
    <dbReference type="OrthoDB" id="19690at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601:SF5">
        <property type="entry name" value="EG:132E8.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="8"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="156" mass="17562" checksum="36EF46217B4C32C2" modified="2022-05-25" version="1">MTSNPAMCKFLQRIPVRSLLSISTQGQLVTASPGSRNFHQSEPLMDIFEIQNEDEFKNKVMRNSLPVIVNFHADWCEPCHSLRPLLKKIATENVGQLHLAEVLVDEHAELLQAFEVTAVPAVLGIHRGMVIEKFVGLVTHKEVKGFVEKLLHKNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCR1</accession>
    <name>A0A8J5NCR1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G000649</name>
        <name evidence="2" type="ORF">Hamer_G032120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025464">
        <property type="protein sequence ID" value="KAG7164517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCR1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="216" mass="24835" checksum="0A09D0AD8C851B7D" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDLGDCSFHSRKVPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ND69</accession>
    <name>A0A8J5ND69_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ND69"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="72" mass="8634" checksum="4B2A1E61D0635638" modified="2022-05-25" version="1">MISNYKCIVDYKNMVSHTKKKKKISTCQTLSIHLCYCMLMYILYLAFLSPNYFIFVLLELQPPPIYFTCFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T0Y6</accession>
    <name>A0A8J5T0Y6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G023112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011989">
        <property type="protein sequence ID" value="KAG7171691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T0Y6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035271482" evidence="2">
        <location>
            <begin position="21"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7171691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="654" mass="71875" checksum="938EE1AF31DBF2F7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T258</accession>
    <name>A0A8J5T258_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Forkhead box protein I2-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Foxi2-a-L</name>
        <name evidence="6" type="ORF">Hamer_G000872</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T258"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20035">
        <property type="entry name" value="FH_FOXQ2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000352">
        <property type="entry name" value="Forkhead box Q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047519">
        <property type="entry name" value="FH_FOXQ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="151"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="151"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="479"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7171930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="619" mass="67611" checksum="6A112F701D46AA37" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIV5</accession>
    <name>A0A8J5TIV5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ES1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Es1-L</name>
        <name evidence="1" type="ORF">Hamer_G009002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIV5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03133">
        <property type="entry name" value="GATase1_ES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008747">
        <property type="entry name" value="PRK11780.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10224:SF17">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10224">
        <property type="entry name" value="ES1 PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="289" mass="30303" checksum="044810F98DF6FAE2" modified="2022-05-25" version="1">MQSRIANGHCHSDHQLVASQCAESLLEHHKNLIVATMFNVARTASRNIYARLFNNSASLQAPTVAVVLSGSGVYDGSEIHEASAALVSLTRSGADVICYAPDAPQMHVIDHTKGSPAEAETRNVLTESARIARGNVKPITELTSGTADAVFFPGGFGAAKNLSDFAVKGADMTVISEVERVIKDFHGAKKPLGFCCIAPILAAKVLGGSGVTVTLGKADDGSGKWPYAGSIEVAKALGATTVEKAVDEVTIDEANKVVTSPAFMYEGKFHEIHDGVSKTINALLGMINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJG1</accession>
    <name>A0A8J5TJG1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosylmethionine sensor upstream of mTORC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Probable methyltransferase BMT2 homolog</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bmt2-L</name>
        <name evidence="6" type="ORF">Hamer_G015468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJG1"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7176654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="456" mass="52102" checksum="7CD26A5929A2268E" modified="2022-05-25" version="1">MNDEGKRLAEVVKGTHKRLRRRYKLGEDETQVWQQHIQHVEELHTYANAMHTLATQHWEPRQQVNTSRVTWVHNAIMQYFHGGDIQRTTDKEMRKLEHLGLKMDESNIADRCKVLLTSRVKVLDVGSCYNPFLVYKEFDVMAVDLCPAHPSVKKCDFLSLEVVKKPIEDNPVKTDVHSHPKLLLQSDKHESTSKITSVTTDTLQDTKLLVSDISNTSQQATGKVELTEPISSDKNSKEGATAAMPEATTNSKSTPMRILDGDTRLSTGMSREGRCSPEMSNTSMAEWSRSVEVNENVEPKTDQVPRDETVACLEGGSFDAVVFCLLLEYLPSPKHRFLCCQKAYNLLRHNGILCVITPDSKHQNANVHLYKLWKITLGYIGFSRTKYEKLTHFHGMVFRKGLYKEAWRLDAARELSLMKKTIVKNKFVGINYDKIDSEVYIPQDFQDVSDSEEETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJN9</accession>
    <name>A0A8J5TJN9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box only protein 21-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Fbxo21-L2</name>
        <name evidence="2" type="ORF">Hamer_G009045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJN9"/>
    <dbReference type="OrthoDB" id="28868at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053189">
        <property type="entry name" value="Clp_protease_adapter_ClpF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02097">
        <property type="entry name" value="yccV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48439">
        <property type="entry name" value="HEMIMETHYLATED DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48439:SF1">
        <property type="entry name" value="HEMIMETHYLATED DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemimethylated DNA-binding" evidence="1">
        <location>
            <begin position="127"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="237" mass="27995" checksum="F6BEB4C4A5218C82" modified="2022-05-25" version="1">MFYSLSRLTMPLSGRDAVVLCVLVCCVPLQHWLTQHSSVTPDERSAEVYRLVEYARFVAQKWLSTASWKDWLLSVQLKYTTNDYSHWYNLDDDDPEGECPAVEVWNYLFPDGAFGMSPKPRNVRPEGMKWRIGQVVRHKIWGYKAVIFGWDPKTKAPEEWIQKMHRENTHWREQPNYALLVDTDQKDIVQITYVPQENISPVTNQEVHHPGLSRYFDYFDGAQYIPRPWLRAVYPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJX3</accession>
    <name>A0A8J5TJX3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">A disintegrin and metalloproteinase with thrombospondin motifs adt-1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">adt-1-L1</name>
        <name evidence="12" type="ORF">Hamer_G000182</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metalloendopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF294">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 7-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13582">
        <property type="entry name" value="Reprolysin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035212219" evidence="10">
        <location>
            <begin position="22"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="11">
        <location>
            <begin position="237"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="746"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7176969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="776" mass="83473" checksum="EE05515D646588D0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLJ9</accession>
    <name>A0A8J5TLJ9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolysin TIAR-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIAL1-L</name>
        <name evidence="5" type="ORF">Hamer_G000233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLJ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="99"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="207"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7177015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="373" mass="42480" checksum="C47C819424B11D8A" modified="2022-05-25" version="1">MAHSEQNRTLYVGNLDSTVTEDLIMMLFGQLGEVRSCKMFREPTTDPYCFVEFCDHMTALNAITMMNDKMLQSRKMRVDWATGQGNKNKYTKVDTSRHHHVYVGDLSPEIDEQALREAFQVFGEISDCKVVKDPQSFKSRGYGFVVFVKKMDAETSISAMNGQWLGRKMIKTRWATRKPANTPNDNKPEQKKLIYEEVYNQTTPTNTTVFCGGLKQDISEEMLHKSFQPHGQIEKIKIFKEKGYAFIKYTSKESACQAIVELHNSNLNGQIIRCSWGKDTGVDQANNPSQDANGAQPSMPSYPNGGGYPSQMGQMGYWQYYPQQMSYNQMPYNQYAYGYQPNPGYMWMGWGQQGWSQPGQPGPPAPQQGQPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TM54</accession>
    <name>A0A8J5TM54_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TM54"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="97" mass="10443" checksum="D5CE50F2098BACBF" modified="2022-05-25" version="1" fragment="single">GTIDGVDYRALLADAVSLLDDQAIQSSLVFMELVAVMGQVGAVTLNGLVLETDYFTTTTDQTIPITVTFGDLATADVIVDGMVNTWYLPVEVRVTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TPD6</accession>
    <name>A0A8J5TPD6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glutamate receptor-like 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Glrk-L40</name>
        <name evidence="12" type="ORF">Hamer_G009195</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TPD6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="11">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7176388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="135" mass="15144" checksum="DF464C28C021FEB3" modified="2022-05-25" version="1" fragment="single">MGHKFRVVVRRYFPTIDFHRVGKGTDTLVSLRDSLNTRMLQAITPHLNITYELHEAWDGEWGALGSDGNWSGLVGTLQHQKADFSTTITPTAPRLLVMEHIRIYASDPFIIISAKPRPLAPSQALITPFTGEFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TSY0</accession>
    <name>A0A8J5TSY0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TSY0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="116" mass="13239" checksum="48844A3142A8FB5B" modified="2022-05-25" version="1">MDCGTRLMISYLTINVQYCEENHLCVKTVAVKDAKGKHEIEDMKRLVQETLTDYGIQKQNILIFSVDNGSNMIKTIKVLNNDEEEDMEEKDDDQNLEAEQLGNADSLLEVQIDAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TTL1</accession>
    <name>A0A8J5TTL1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TTL1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="89" mass="10020" checksum="E001E64DED1547D0" modified="2022-05-25" version="1">MKGQVSLLEILVKEIFAKTRGTSTFQLGNHVSNLLHGLHLLLQVLIFQKLGQSENLHNLEDKKTTHLVDLPFQIQSSLQGIMSITPFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J896</accession>
    <name>A0A8J5J896_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Digestive cysteine proteinase 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LCP1-L2</name>
        <name evidence="10" type="ORF">Hamer_G017740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046276">
        <property type="protein sequence ID" value="KAG7153915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000039">
        <property type="entry name" value="Cysteine proteinase 2, putative"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035274325" evidence="7">
        <location>
            <begin position="17"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="105"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="287"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="372"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="537"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="622"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="787"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="872"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="1073"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="1158"/>
            <end position="1338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7153915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1353" mass="149758" checksum="11E53258356E4F93" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JBY1</accession>
    <name>A0A8J5JBY1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dual specificity mitogen-activated protein kinase kinase 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Map2k4-L</name>
        <name evidence="11" type="ORF">Hamer_G015676</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043233">
        <property type="protein sequence ID" value="KAG7155071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JBY1"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008545">
        <property type="term" value="F:JUN kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06616">
        <property type="entry name" value="PKc_MKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000090">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000126">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF15">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="246"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="87"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7155071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="547" mass="61260" checksum="1A264624FC113E6B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDM3</accession>
    <name>A0A8J5JDM3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA 3'-5' helicase BLM</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Blm-L</name>
        <name evidence="17" type="ORF">Hamer_G012068</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003558">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000495">
        <property type="entry name" value="RecQ family helicase MusN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="820"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="962"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="14">
        <location>
            <begin position="1297"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="338"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="676"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1386"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1394"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7155925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1477" mass="165794" checksum="4D56D0A68C6690C7" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFR1</accession>
    <name>A0A8J5JFR1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044051">
        <property type="protein sequence ID" value="KAG7154750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFR1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="407" mass="45392" checksum="5D70217C6D512BDC" modified="2022-05-25" version="1" fragment="single">WRLVAVGGGEEAVGGGEAGGGEEATGGGEVKLVQEEATVAGGGGWWQEEAAGGREEAGWWREKVVGGGEEAVGGGEEAAGRVDDEEDSGDKELINDMIVPLLHQWTKANALFKPPVINQCRTIEPKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVSELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSKEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPQWPSHTQSVERCVKMVTEAAGHVYSHERREDLQGDKSLSRFLGEEITTQEQPDFKRKSCTIKPDFGKKKKSNTDTPLFQEEEILKWEFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JG50</accession>
    <name>A0A8J5JG50_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="13">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ddx11-L</name>
        <name evidence="18" type="ORF">Hamer_G019198</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="13"/>
    <dbReference type="EMBL" id="JAHLQT010037402">
        <property type="protein sequence ID" value="KAG7157562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JG50"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001372">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="6"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="95"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7157562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="895" mass="99727" checksum="B1A2B86C48A025B1" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JG53</accession>
    <name>A0A8J5JG53_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrator complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">IntS11-L</name>
        <name evidence="14" type="ORF">Hamer_G019176</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037402">
        <property type="protein sequence ID" value="KAG7157542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JG53"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16291">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000002">
        <property type="entry name" value="Integrator complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000028">
        <property type="entry name" value="Integrator complex subunit 11 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041897">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048662">
        <property type="entry name" value="IntS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF37">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21386">
        <property type="entry name" value="IntS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="16"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="13">
        <location>
            <begin position="244"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="470"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7157542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="618" mass="69096" checksum="E1542AF4A04B455C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JH22</accession>
    <name>A0A8J5JH22_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beta-1-3-galactosyltransferase 1-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">B3galt1-L6</name>
        <name evidence="13" type="ORF">Hamer_G021229</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041527">
        <property type="protein sequence ID" value="KAG7155485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JH22"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF379">
        <property type="entry name" value="HEXOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="324"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="589"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7155485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="931" mass="100193" checksum="2A833352A5EE4F36" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHS2</accession>
    <name>A0A8J5JHS2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035473">
        <property type="protein sequence ID" value="KAG7158337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHS2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="183" mass="20974" checksum="0F273B597E5C9D38" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKRENNSHIDCGCPRENKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQRKEELCQDLGDCSFHSRKVPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JI82</accession>
    <name>A0A8J5JI82_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD-linked sulfhydryl oxidase ALR</fullName>
            <ecNumber evidence="3">1.8.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Augmenter of liver regeneration</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Gfer-L</name>
        <name evidence="14" type="ORF">Hamer_G006534</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JI82"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="13">
        <location>
            <begin position="113"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7156558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="223" mass="24759" checksum="ABF6C72AB0D02E4A" modified="2022-05-25" version="1">MMATERREDVVGGLPHPEQTPTDKPCRACTDFRSWMKSQRRAGPVTLGKAETSSTEAPPPENSSGSSSERQENSGLESGSVLAGRANDGSSQTSTVPEETDVPLWGQAAKYGCPADSLSLGRGSWRLLHSMAAYYPTQPTPQQQNDMKTFITIFSKFYPCQPCAEDFREWLKTNSPAVDSRSTLSRWFCEAHNEVNRKLEKPLFNCDLIDQRWGDGWKDGSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJK3</accession>
    <name>A0A8J5JJK3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041500">
        <property type="protein sequence ID" value="KAG7155488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJK3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="234" mass="26561" checksum="63F4EC9D9BBE5C1D" modified="2022-05-25" version="1">MHYRPVPADIAIIGEYPQTSHYRPVPRYGHYRKTTITAKYLLIPSITAQYLQITTITAQYLQITTITAQYLQITTITAQYLQTPSFTGQYLQTPSITGQYLQTPSITVHYLQTPSLAVHYLQTPSLTVKYLLKKKLSSFEIFRVMNFVAWERKIFAASTARAPAQLSTDLNFQVRKMATNQQSRLVEKSVHETESSSSSSEGDDKVHDLEDEVFQALYETPTGMKKTVTFSSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKB0</accession>
    <name>A0A8J5JKB0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PRRC1-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prrc1-a-L</name>
        <name evidence="6" type="ORF">Hamer_G018730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRRC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036987">
        <property type="protein sequence ID" value="KAG7157668.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Protein PRRC1-B"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRRC1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN PRRC1"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN PRRC1"/>
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    </dbReference>
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        <property type="entry name" value="NTPase_I-T"/>
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    </dbReference>
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        <property type="entry name" value="ITPase-like"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <begin position="328"/>
            <end position="443"/>
        </location>
    </feature>
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            <begin position="80"/>
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    </feature>
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    </feature>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00010298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7157668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="508" mass="53739" checksum="A61610E3BB2539EB" modified="2022-05-25" version="1">MRSMNAQDMIHQAQDVFDRVTHRSSPLLPTFMENTSDTSSSTSSVLTNVAPPSALPSFIASPLSSGALVRGPPPSPNSPSPGSMPLGPAGTPAVGPPVSALGLTPGPPPPSGHSPPPASAPPSLPGSGSTQTLEPSFVPPPSPVTSQPQPPVRQQETISLVTKGHLRHHSYPVYIPGNPMHNPPPPPTPPCLVVQQEQAASSAISKSHSHQYPHSTVEGTYHSREQPYGSPPYVDFFGNSVSYGSAYPPHSQGSVDASVDLGSPGVGGPSGKPGGNGWFGWIRGTVSSVGHRVAERAKTSMDTMITTLDPQMKEYIHSGGDMDILVASDKEIKVGGVREAFQFMFGKATVSGMAAQAESVAAQPVGFEAALHSAEERINSLRTSGRVHPQQPVVSVENFIVELTPDCWFDVGLLLLDDPGEDILLQTYTQVTPIPPDFVTQAKNSTPDDYPYKSSGFAATVGQIASQNLEVHHTMWQETLTGVSRREMIVLAARALAGLYKSRLPHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKG5</accession>
    <name>A0A8J5JKG5_HOMAM</name>
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        <submittedName>
            <fullName evidence="3">Nuclear receptor coactivator 6-like 1</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">Ncoa6-L1</name>
        <name evidence="3" type="ORF">Hamer_G021466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036980">
        <property type="protein sequence ID" value="KAG7157773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="NCOA6_TRADD-N"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 6"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="132"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="2219"/>
            <end position="2285"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7157773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2319" mass="245796" checksum="BFF3400FA72B927D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKX3</accession>
    <name>A0A8J5JKX3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hemocyanin C chain-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HcyC-L1</name>
        <name evidence="4" type="ORF">Hamer_G005780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tyrosinase family. Hemocyanin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="8119704at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
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        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF5">
        <property type="entry name" value="FAT-BODY PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00209">
        <property type="entry name" value="HEMOCYANIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035268567" evidence="2">
        <location>
            <begin position="16"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7157360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="675" mass="77844" checksum="63FCC2A900FDFCCF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLG0</accession>
    <name>A0A8J5JLG0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G008801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLG0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="286" mass="32541" checksum="760EA0E3C2B7526A" modified="2022-05-25" version="1">MIAIAFIAAAVFIAATARKTFRYTRRKRETTSVISDNNLEEHTCCLKYDPNNLALTRFIVMTKLTELVTEEVGIYWQNNGCRERERMWRDSGCGKTEGVARQRVWRDSGCAAGELTGTLVTLFHYRDLPRSRRTGLTRVAEDERIVADIRDHPFTNAVTTTERLHLEVSAWTAIFVSLPCLMKVLKKLSDAAKLVRRESETVSTDLQFRDTRMLSTPQVSPMFQLLALARRTRVRPRVAWLFIMPVALSFAILNLIISLTTTMLIPSLGLLTATTPDAALRQRRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLY8</accession>
    <name>A0A8J5JLY8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Prostaglandin E2 receptor EP4 subtype-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Ptger4-L1</name>
        <name evidence="14" type="ORF">Hamer_G017434</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7159991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLY8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008365">
        <property type="entry name" value="Prostanoid_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866:SF16">
        <property type="entry name" value="PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="82"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="236"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7159991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="432" mass="46267" checksum="F414DFC0CAA5A8F2" modified="2022-05-25" version="1">MLSSQSTQIPGVITTMESSLLAPPCPIETNGDCEGIRSLLAPPCPMEGGEECAGSVNCTMISSQPGATIVSPILLCLTGVIGQVWALCYLYGNTRRQNTRTVFYVFLCTLIWTDFVGKIITTPPAIISYAYGAWVGGKAMCDYHGFSMVLVSMLTHFTVSAMAVERFLGICQGYFYSRNVTPTRCSQKVVRSDKVVRSDKVVRSDKVVRSDKVVRSDKVVRSDKVVRSDKVVRSDKVVRSDEVGRSDKVGRSIGEEQGGAQGGVGGGAQGRSTGEEYREELSKGGVNRRRSYQGGAQRSGGAREEGTEEEHRRNKGRSTERRQGRRQREEQRRAQGGVSGEEHRGGVTGGQGGAGGGAQGGVSKGGSRGRSYRGGAQGRSKGEETEGGAQEEEYKGGVNRGGAQRRSTGEELWGGAQGVIKGRIKGELTEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JN45</accession>
    <name>A0A8J5JN45_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein kinase 11-interacting protein-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Stk11IP-L6</name>
        <name evidence="6" type="ORF">Hamer_G029670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034570">
        <property type="protein sequence ID" value="KAG7158575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JN45"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="615"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="695"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="808"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="863"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="817"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="864"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="905"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7158575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="915" mass="101377" checksum="FF367C4740CA9B18" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JP18</accession>
    <name>A0A8J5JP18_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neurobeachin-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rg-L2</name>
        <name evidence="3" type="ORF">Hamer_G021040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028818">
        <property type="protein sequence ID" value="KAG7161697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JP18"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010508">
        <property type="entry name" value="NBEA-like_DUF1088"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF162">
        <property type="entry name" value="NEUROBEACHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06469">
        <property type="entry name" value="DUF1088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="2">
        <location>
            <begin position="91"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="138" mass="15423" checksum="70229FC973018EDC" modified="2022-05-25" version="1" fragment="single">APPQFWKLDSWEDDSRRRKRFVPNPLGSSHPEATLKAAIEHGAPEDAILQAREEFHAQLAAQRRSLQQPLQSPDLLDDSELTTDDRDLDADVTGMVNMSTRARLVAPGLMVPGTVSITAAELYFEVDEEDPEFRKADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JP58</accession>
    <name>A0A8J5JP58_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatidylinositol-glycan biosynthesis class X protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Pigx-L</name>
        <name evidence="11" type="ORF">Hamer_G016596</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Stabilizing subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PIGX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JP58"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040039">
        <property type="entry name" value="PIGX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7159205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="254" mass="28131" checksum="FFAFEFD4D72D0012" modified="2022-05-25" version="1">MILMHRNSLLIKKMACVTMLATAFVVISLVPVSWASTCPLVLKTNAQVERRLLNEGFHRDLETTVFLSSPEDLQSCLVLIKEVLPPGSYVDPNQLRFLRAFGGPDFHVPQIINVETPEHLSPRVLAYFYILPQPMSDGRWLVNITVPIHLRYHRARSGESYSLEVPVRLQHPAVLVQCEDVGGDACRPLVQLEPCPPSGVQLCEWLPVNTFSTSEAVMGIVPVGNTDLLDTVLLTTTCITAGATLLILATLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JP82</accession>
    <name>A0A8J5JP82_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MAGE-like protein 2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Magel2-L1</name>
        <name evidence="2" type="ORF">Hamer_G008838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6361704at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="676"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
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                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
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                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
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            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Homarus americanus</name>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Greenwood S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">GMGI-L3</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Putative RNA-directed DNA polymerase from mobile element jockey-like 69</fullName>
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    </gene>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Timp W."/>
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                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
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                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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            <begin position="1"/>
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        </location>
    </feature>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="153" mass="17217" checksum="DDD3BCC8ECB45CF5" modified="2022-05-25" version="1">MEGKCHKRLRKEEDFSDMDNMSPAIHPVAEPPTVANPNVTKYKIPKETEFDHACEVVVALELEFKNIKFSVNPNLVGDLILSPQDNKTAKILSEVTNLNGRTVMIIPLDPEEKTTRMVLLRYLLELPVAVIVKHPKVAKAERCASSQDKAQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRM0</accession>
    <name>A0A8J5JRM0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G024969</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">American lobster</name>
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            <taxon>Pleocyemata</taxon>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030679">
        <property type="protein sequence ID" value="KAG7160803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRM0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28011" checksum="A0740051F0D41160" modified="2022-05-25" version="1">MKIEFKQAKRENYSQSEKLTDYAEKIIQRTPYIPCARTIAPVATAPIKVKKETGTKPKQNTVCKICKKQNHRTEDCFYAPQDGNTYQFNKAKRSNFKNQNQKLNPNAVSKTYNASETKTSLIAALSKVEVLTIPVSAGNTKLSLDIDTGACVNVISLTSFTELNRRSPDNKWQIRPTDVDLSGVSGQHLDIMGVITLPIGFCDSSEIFLAEFYVVKDFSLPADGLLVQFLGHVVDGNGIHTMDCKVKAVEQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRT2</accession>
    <name>A0A8J5JRT2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NT-3 growth factor receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Ntrk3-L</name>
        <name evidence="8" type="ORF">Hamer_G001858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRT2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043121">
        <property type="term" value="F:neurotrophin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005030">
        <property type="term" value="F:neurotrophin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990090">
        <property type="term" value="P:cellular response to nerve growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF614">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="343"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="350"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="421"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7160570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="604" mass="68398" checksum="307B651F26AD48A1" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSA2</accession>
    <name>A0A8J5JSA2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Hamer_G004367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSA2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7163260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="108" mass="11553" checksum="2AD3B5B6605D3541" modified="2022-05-25" version="1">MLALHTEFSNKPPYQLYGGTAQAQHGAGRPGMPHQVHTPAGCHGNSVALSTGVAVPTSVSLSGGQSEEEATVHLDTINKCTARQKTLGPDLQLREKPCRRKPLKKLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTX5</accession>
    <name>A0A8J5JTX5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G030011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028248">
        <property type="protein sequence ID" value="KAG7162018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTX5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="132" mass="15552" checksum="F95F0A32590A43BA" modified="2022-05-25" version="1">MGLRFSHFFQIVRLRGERLTEVNMWLVENSSKQSYVLKPTLPNISTEENQRKLVMIGNITRYLSPVSQEITLQYHYHYYFSADTSVMTPHKVKHFHSAIGVQCPDCQHLVQYDVTSGQLNLRRKSVQYTIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV72</accession>
    <name>A0A8J5JV72_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G004706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7164972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JV72"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="199" mass="21657" checksum="B947571D370D01C0" modified="2022-05-25" version="1">MTPSSSTCPHDALNICPHMTPSSSTCPHMTPSSSTCPRMTPTTFTCPHSATTSNCPHDALNIYLPHQCPQHLLVHTRPSTSLSHTTPSTSTFPSQRPQHLLAPHMTPSTSTCPRPQHLLVPHMTPSTSTCPHMALNIYLPTHDASTSTCPHDALNIYLSTHDAHNITCPHDALNIYLSTHDASSSTCPHMTPYHLLVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWF4</accession>
    <name>A0A8J5JWF4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Ada-L1</name>
        <name evidence="11" type="ORF">Hamer_G004867</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWF4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060169">
        <property type="term" value="P:negative regulation of adenosine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF43">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7165091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="412" mass="46109" checksum="0A6DB1DE269E2870" modified="2022-05-25" version="1">MRHVQLHVHLDGCIRHETIWEVMRRKGLKLPGSGSLADLKLALQVQEPEDLLFFLSGFKIFLPAIKGDLAVIERIAHEFVEDQAKEYVAYCEARFCPHLLLPNDTTQFSVVKCLKGKSRVNGTTDTTTEDGPVKDGEVTVDSILNAVLKGFSRGEEDFGTKVRVILCCIHGTSEWYWDILRLCEEYRSKGVVGIDLAGYHECSDWSTEDQSLKEDRVLVEVFEAAREKGIHRTIHAGEAGPASTVKLAVEALGAERIGHGYRVVEDESIYQMCLKENIHFEVCPHSSYLTGSIGSLKTKSKRHPVLRFAEDEASFSINTDDPTITNTQLMDEYKLLTEWGFTEAHFTRANFQAAIHSFLPIEEKKALVDQLHEAYGIVNFTLPSPTVSPSSTRTSTPPPKPSVTFGTWAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWI8</accession>
    <name>A0A8J5JWI8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protocadherin-like wing polarity protein stan-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">stan-L2</name>
        <name evidence="10" type="ORF">Hamer_G029427</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027481">
        <property type="protein sequence ID" value="KAG7162629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWI8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF51">
        <property type="entry name" value="PROTOCADHERIN-LIKE WING POLARITY PROTEIN STAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="235"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="391"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="681"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="830"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="734"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="801"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1104"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7162629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1227" mass="137426" checksum="697B04AE4896FCC9" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JX94</accession>
    <name>A0A8J5JX94_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Heparan sulfate 2-O-sulfotransferase 1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HS2ST1-L1</name>
        <name evidence="12" type="ORF">Hamer_G002200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfotransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JX94"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004394">
        <property type="term" value="F:heparan sulfate 2-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001418">
        <property type="entry name" value="Heparan sulfate 2-o-sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007734">
        <property type="entry name" value="Heparan_SO4_2-O-STrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129:SF17">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7163124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="338" mass="39141" checksum="AD46B8BE33008158" modified="2022-05-25" version="1" fragment="single">EQFPNEEFTCGCVIDSGSECCGDAPVPSLSNRTPLSYQEGTPPVGRNILDPDNLVIIYNRVPKTGSTSFIGLAYDLCSKNKFNVIHLNTTRNTPTLSLTDQMRFVYNVSNWVEKKPGIYHGHLAYLDFNRFGVSQQPIYINIIRKPLDRLISYYYFVRYGDDLRPYHIRRRMGDKMTLDECVAMEHPDCSTTHLWVQVPFFCGHHAECWVPGSGWALEQAKHNLLHNYFLVGVTEEMVDFVAMLEYSLPRFFRGSYDLYLSGSKSHLRKTVKKILPSEDTIAKLQNTKVWRLENDFYNFALDHFHFLRKKTLVESEGNGHLMNRGQKFAYEKIKPKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXG0</accession>
    <name>A0A8J5JXG0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G011054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXG0"/>
    <dbReference type="OrthoDB" id="6382578at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035249651" evidence="2">
        <location>
            <begin position="18"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="477" mass="52786" checksum="A2FA145036AD3F29" modified="2022-05-25" version="1">MKLLVYYSLALMVVVNAAPSQPMTVKVVDREENVSSAKTPRHTWFINTHRSDTLPGTGGDQDETGVEVDRDDNTSLASIDSAEDKVTSDESSVLTDLCQMEKDLYLIHLLLGHSSNPNTNRCASFGTRVHFDMSDNEPKDDYFDYHDYNYDNNGGSGSGMFGFPGFDFDSSKFPGYSTFDIERKDDSFDYYDYDNNGGSGSGMFGFPGFDFDSSKLPGYPSWLPESPSIPKVDDLPDNYDNSTHDVHLVNGTRVEVNTTTNKKSGDGFTSFYHHQFINIRPDQVPDDEDKETPQVKEDTDEEETVGEEEGVGEEEGVGEEEGVGEEKVPVYDEELLVIPQVENEVSSSDFPAHIPNLNEVSSSDFPTLNEVVPTEHVATDEGLVGGGGGVKLLRSRRSLNTIHFPQPAKPAAYVDQDTEEVDVDEGHHPKPDLSSDTLVNHVNRDHQGLSKVDPDAEIFNLTLVLNEGKLKDNDDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXK2</accession>
    <name>A0A8J5JXK2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G005527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022531">
        <property type="protein sequence ID" value="KAG7166427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXK2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="87" mass="9604" checksum="1052CF070C1803DC" modified="2022-05-25" version="1">MSPAVHPVEEPPTFAIPTVIKSVMIALGLEYKNIKFSVKPNLVGDLILSPQNHNTAKIFSEVINLNGKTIKIIPLDPEEKTTRMVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JY12</accession>
    <name>A0A8J5JY12_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoglucanase</fullName>
            <ecNumber evidence="9">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">celD-L1</name>
        <name evidence="11" type="ORF">Hamer_G002836</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JY12"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033126">
        <property type="entry name" value="Glyco_hydro_9_Asp/Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="Carbohydrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00698">
        <property type="entry name" value="GH9_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035340955" description="Endoglucanase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="10">
        <location>
            <begin position="153"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="533"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7163619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="562" mass="62467" checksum="40FAF8CDEECB4EFA" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JY65</accession>
    <name>A0A8J5JY65_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025502">
        <property type="protein sequence ID" value="KAG7164238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JY65"/>
    <dbReference type="OrthoDB" id="6359412at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035174485" evidence="1">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="133" mass="14789" checksum="A0CB1B947E2E6F46" modified="2022-05-25" version="1">MKYLVIFLATLSLAWGQEIHCHCVTAVTVEDGAELIHGLPFTEVVDCSNFEECELRCSEEFTELTNGGDLDFVLDNGKVVGQVACDNLAKEGYQDLEPSEVYMYSSICHGPWLYNGFKSQQKLCCEGGQYTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYV1</accession>
    <name>A0A8J5JYV1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Neuromedin-U receptor 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Nmur1-L2</name>
        <name evidence="13" type="ORF">Hamer_G020815</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026066">
        <property type="protein sequence ID" value="KAG7163900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYV1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="98"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="417"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7163900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="455" mass="49527" checksum="8DBDA33716394496" modified="2022-05-25" version="1">MTWCVCHVTLAHPVTSCDIMALEESTGIYNWTMTSSTMPTASVTLDDLTPEEEELMEDPFYNMSASTNSSLTPPYQMVEVGVATELTAVVVLVVGVVGNLMVMVVFLWRPWGRTPLQVDRVVGLLALTGLSATLISVPFHLYSFLAGTYPAQGSLCQVQGFLLNLLCLLCLWYTTVLAVERYVKFASPHEHSLTFSLLNLNVVLSGVLVLLMIEVSGPIYGWAEYGYVPDCGVCVLNPVSTHILTYTVIQTSCYVSLPALLTVCAACCVLHRCNTQPGPLTQGSQCCSCCPTTPSSCCRRHRSPSQSGASKEGLMTYAAGSGERERERERERENNRCLQQVASYWSKIISLACVYPVILLAARPTEVWPPLVSRLHTFKRCRLGGLLHHSDPALDLSSLEVGGIDLSLRKSRRISRSSHATDTTVVSASPSHSTKDTSSSNTTTTTTAPSSVTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYZ2</accession>
    <name>A0A8J5JYZ2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="2 9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CTDP1-L</name>
        <name evidence="13" type="ORF">Hamer_G017113</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2 9"/>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYZ2"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000007">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="12">
        <location>
            <begin position="140"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="629"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="331"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="805"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="420"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="811"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="852"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="888"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7167207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="913" mass="102755" checksum="2ECC14590ED61DF7" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZ18</accession>
    <name>A0A8J5JZ18_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025477">
        <property type="protein sequence ID" value="KAG7164264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZ18"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="722" mass="82810" checksum="CA29E4A3FAC80E21" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZ32</accession>
    <name>A0A8J5JZ32_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZ32"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="533" mass="58102" checksum="CA3AE7CABD0C173F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZH0</accession>
    <name>A0A8J5JZH0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bifunctional purine biosynthesis protein PURH-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Atic-L2</name>
        <name evidence="1" type="ORF">Hamer_G002920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZH0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="226" mass="25297" checksum="0AEAB50A917F92EA" modified="2022-05-25" version="1">MDPEYKGNLVERRTIFGLTLEQRRNDASITPDLLSNIVTKNKQLSKESIRDLIVATIAVKYTQSNSVCYAKSGQVVGIGAGQQSRIHCTRLAGDKTNNWWLRHHPRVLNMKFKEGVKRAEKSNAIDNFVCGTVGKDMPESQFAAVLEEIPAPLTEEEKESWIKKLNGIALSSDAFFPFRDNVDRSRQSGVDFIVSPAGSTNDSLVVDACDEHDMVLVHSNIRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0Z5</accession>
    <name>A0A8J5K0Z5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pancreatic lipase-related protein 2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Hamer_G011002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0Z5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF185">
        <property type="entry name" value="LD47264P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035275913" evidence="5">
        <location>
            <begin position="20"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7166181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="377" mass="42353" checksum="7249F9A46E879A51" modified="2022-05-25" version="1">MYLHAIEISTLALILGVTAVGSQVIGSEERCYGELGCLVLDGQWWHPWRRPINLWPYDPAVINTTFTLHTRPAPSHQQYQLKKREVVLLHPEDHLSLALSPLDATKPTKVIIHSYHENLNTPWVEELTEALLQYGDYNVIVVNWAGGSSTYYLQAVANARLVGLELTHLLLTLQHTINLPPHSLHLIGYALGAHIAGYAGERVAELGRITGLSPPALFFEELPPVVRLDERDAAFVDVIHTNINGHGISQRCGTVDFYPNGGEEQPGCGRHTTENRDMFRVDLTNVMSQQSCSRMRALDLFLTSLTCPACFLGHECTDKYLYAYGMCYVCGEPNNHCGYLGIRAQEFLVQRRERLALYIFTSDTHPYHGNHTHQPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K114</accession>
    <name>A0A8J5K114_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoglucanase</fullName>
            <ecNumber evidence="9">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">celD-L6</name>
        <name evidence="11" type="ORF">Hamer_G012870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K114"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033126">
        <property type="entry name" value="Glyco_hydro_9_Asp/Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00698">
        <property type="entry name" value="GH9_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="10">
        <location>
            <begin position="124"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7167416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="548" mass="61052" checksum="329FC6F03522A7B4" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K424</accession>
    <name>A0A8J5K424_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G022961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014835">
        <property type="protein sequence ID" value="KAG7170207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K424"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035204791" evidence="2">
        <location>
            <begin position="23"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="73" mass="6779" checksum="7466B4112A8212D3" modified="2022-05-25" version="1">MVQWRALLVLVLVAVWAVDVNAAPAAEAEAVAEPCCGGRRRSGGGGFGGGGGFGGGSRGGGGFGGGGGGGFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4S3</accession>
    <name>A0A8J5K4S3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Guanylate cyclase 32E-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Gyc32E-L2</name>
        <name evidence="6" type="ORF">Hamer_G023447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016841">
        <property type="protein sequence ID" value="KAG7169411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4S3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7169411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="197" mass="23239" checksum="01D2F92AEF7612FC" modified="2022-05-25" version="1">MPASTKIVKALISLMKAYSWRQFVLLTEHTRNYLQIKEAVKSFAEHHRLNITQEYSVPYDYTTNRYHIMQEIVHSSLHVTRVYVLVASFEVQWDFVLALREAVMDDLEEYAIVTIDDDKYLGLNGTQMRGKQIVTMSEELAERLYLGFRAVVKITPAYPNNTKYREFEQKVLNRIKKHPFCVPYNPQIFKYITVSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K530</accession>
    <name>A0A8J5K530_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G010462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K530"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="228" mass="25200" checksum="0AC049D1F0B3A1CE" modified="2022-05-25" version="1" fragment="single">VGGELVVVLHLGGDSLLHQPFHRLYAVVLGRQVEWSGPVSVLGVLRPLEDPFTAAPCASASCTPWLFPVRAKCSCGNPEGYVMEASFTRDDDVNCACVCRAASLISWRLPEIYLKKEADNSTQINTTPALSVISISFKGSETQETPTEGTSGEDSPQDSSECVVLQQKIRELQHDRLGLESQVSTLQAALDKEREKLDKNHQEYTQIISEQEKEIHNLKINMVSWGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5C3</accession>
    <name>A0A8J5K5C3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G010168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5C3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056707">
        <property type="entry name" value="DUF7805"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF3">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25090">
        <property type="entry name" value="DUF7805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="804"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="94"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7167774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="865" mass="96421" checksum="772C278E00869B16" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K679</accession>
    <name>A0A8J5K679_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 516-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Znf516-L3</name>
        <name evidence="14" type="ORF">Hamer_G012832</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K679"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051967">
        <property type="entry name" value="Krueppel_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45925">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7167383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="141" mass="15350" checksum="C1CE4AADF61F273F" modified="2022-05-25" version="1">MAARHMLVSMVTLPSGSSMATPPSGPAPPSESAMATPPSGPAMATPPSGLAMATCPICGRNFHGPYRATLLRRHLRTHTGEKPYACPHCPYRANICSNLSRHIRSRHPGHPSLLRPQHVDQEPTHQNRDWHHAVPEPPEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7G0</accession>
    <name>A0A8J5K7G0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G018380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7167953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7G0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7167953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="247" mass="25884" checksum="07C0A317DDB674A8" modified="2022-05-25" version="1">MVAPHDTGDLVRSLVRVPGSGSDRSAGSVCCDLARASTLAASVPVSTTLPPALMGSRTPKTTEPNTQENQTSVKNKLGGSVGVQSGVLKSSENVSAATSTAPSQEGAASRKRPRTEEPGNTESSSSTSSGSSGQVPSRADIEDLLANKRARIICMTPQQVAAHASNIVSIPSTQGAGSMLVLQLSQQSLNTAPLIMAPTSVAQLLQERNSLRQENQALQRQLSLFQQLFRNKERLTSVVKRLGVKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7Y5</accession>
    <name>A0A8J5K7Y5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Involucrin-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">IVL-L3</name>
        <name evidence="2" type="ORF">Hamer_G018873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018499">
        <property type="protein sequence ID" value="KAG7169094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7Y5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47202:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47202">
        <property type="entry name" value="HISTIDINE-RICH GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="592" mass="68095" checksum="379533789DCCCC79" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K969</accession>
    <name>A0A8J5K969_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Rpl22-L</name>
        <name evidence="7" type="ORF">Hamer_G013759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012455">
        <property type="protein sequence ID" value="KAG7171301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K969"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF0">
        <property type="entry name" value="FI24544P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7171301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="160" mass="18290" checksum="BB93BFED2795C966" modified="2022-05-25" version="1">MTAAKPPVKKPVAKATGSKKPQKPQVQAKKGKGVKGKVGKGRRGKKLQLKFHIDCRQPVEDGIMNAADFETFLQQRIKVNGKTNNFSNQVSLERNKHKITLNADVAFSKRYLKYLTKKYLKKNNLRDWLRVVAPPTAKDTYELRYFQINNEEDDDDDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K9D3</accession>
    <name>A0A8J5K9D3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Nostrin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">NOSTRIN-L</name>
        <name evidence="18" type="ORF">Hamer_G013218</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015640">
        <property type="protein sequence ID" value="KAG7169619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K9D3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11823">
        <property type="entry name" value="SH3_Nostrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057870">
        <property type="entry name" value="HR1_TOCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035656">
        <property type="entry name" value="Nostrin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25610">
        <property type="entry name" value="HR1_TOCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035261353" evidence="14">
        <location>
            <begin position="20"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="F-BAR" evidence="16">
        <location>
            <begin position="29"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="17">
        <location>
            <begin position="284"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="553"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="404"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7169619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="611" mass="68884" checksum="EEFC1102FC328DA4" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KDR8</accession>
    <name>A0A8J5KDR8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Solute carrier family 35 member F5-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Slc35F5-L4</name>
        <name evidence="3" type="ORF">Hamer_G027504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015336">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7169828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="208" mass="24354" checksum="F572F46769D52D87" modified="2022-05-25" version="1">MTGSDKSFNPERRAAVSGSSRLTGGVTGENSSHAYIFNDTGFNKPFFSTYLKTSMFSLYLLGFIFWSPWRHQCAQRNHDESIYQTRDRRTPPPVPIFTLDQLASSVARDSDANAQLTHLVLWHYLPIQQARTIYNNNDEKVSLNYFCQSYVQELLAFKDMKLRMHYRKKILLKNWKINWHSTQKLKQIFIGVYDDRNMKNEGVNLELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KFL1</accession>
    <name>A0A8J5KFL1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012798">
        <property type="protein sequence ID" value="KAG7171179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KFL1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="171" mass="18588" checksum="6BC21A53A33D5199" modified="2022-05-25" version="1">MAAADEYSTTSHVLQLCLALQDRLEKVEKEVQSLKGENLALKLVLEEKKTFASVVKDGEVNSWKVVDASATKCTLKRHSAVDPNNRFSILSDECEEGASNTTSATPSVSVERGSSAVTMEKMGDFCGYPITSDLGHIRQKGLASIMGISDERGDSLHAKWQKKSFINPHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KFP2</accession>
    <name>A0A8J5KFP2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periostin-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Postn-L1</name>
        <name evidence="3" type="ORF">Hamer_G013744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012455">
        <property type="protein sequence ID" value="KAG7171288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KFP2"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000032">
        <property type="entry name" value="Fasciclin domain-containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035212147" evidence="1">
        <location>
            <begin position="25"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="104"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="249"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="387"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="518"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7171288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="659" mass="73288" checksum="D87D6295ABBDC0E5" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KG03</accession>
    <name>A0A8J5KG03_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019217">
        <property type="protein sequence ID" value="KAG7168744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KG03"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="315" mass="35583" checksum="F723AFAAF94BA660" modified="2022-05-25" version="1">METKAMASVLGQIEVSCSFKLEQVLHNRVTEENLSIFNTNGTMRKMKKIKLREKLIITPIQEPDTYTEDLEKGDGTKYTWGDYRKKVVLTVITRHKNAERIICVNDPYGQRWTIEDSKRMLPQKSASSSNIYMKSEDKIPAIIDFQLLLVSSGEGYTEAVILDTEDTDIYVQAAYDAQQISGVLCLKWKTQFITSRNLGDEEMMACIIPLYVLTGCDHNLASMADRVQSSKEVRDLLASWRAQKKKNTVRLAPDSNAQPPLKADKLSQFSAEVPKPPIPSLTHQTWMAFARWPVPICPLHPAPNSHINTLIPESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KPE8</accession>
    <name>A0A8J5KPE8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5 16">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Naprt-L</name>
        <name evidence="20" type="ORF">Hamer_G012569</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="16">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="5 16"/>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KPE8"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01570">
        <property type="entry name" value="NAPRTase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.140.10:FF:000006">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000155">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000173">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 16" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="17">
        <location>
            <begin position="121"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase C-terminal" evidence="19">
        <location>
            <begin position="335"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG7170994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="459" mass="51336" checksum="D322585F35CA5ADF" modified="2022-05-25" version="1">MLSDMYQINMAYAYWKSGRHGDSAVFDLFFRKNPFHGEFTIFAGLEECLKFLENFKYSESDIQYLKETMPETVEPEFFEFLSNVTTKDVKMHAIDEGKVVFPSLVATNAARYRMAAGRKIKLLEFGLRRAQGPDGGLTASKYSYVGGFDGTSNVLAGKLYNIPVKGTHAHSYVSSYSSLDELHIESEASDGELAAFISFAIAFPSGFVALIDTYDVLKSGILNFSAVALGLHDLGYRALGVRIDSGDLAYLSCVARSIFATIAKGFDVEWFEHLSIVASNDINEETIISLNEQGHKIDCFGIGTHLGCVFKLVEINGEAKIKLSQDVEKVTCPGKKSAYRLYGADGHALIDLMHRTSESAPKCGSRVLCRHPFQESKRAYVSPAKVESLFKLYWKDGKIQQDLPNLEEIRDRVTESLQTLRQDHKRNLNPTPYKVGVTDDLYNFLHDLWLQNAPIGELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKH2</accession>
    <name>A0A8J5MKH2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Myb-binding protein 1A-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Mybbp1a-L2</name>
        <name evidence="2" type="ORF">Hamer_G019970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044137">
        <property type="protein sequence ID" value="KAG7154552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKH2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="142" mass="16471" checksum="6B98FD0A0CAD8239" modified="2022-05-25" version="1">MGRLQLQRVREEAERQAEGKDWTGRIVKVMTLLIDRYSVKLSCKVKLTQQVVPGRGSLPETRLPTCKECGEELCDGLCKDYLYMNYTRLQTVEKKEEESGLDAEEVGTPKAKGKKKRRTKRRKKKKKKESEYPDDDADDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLN1</accession>
    <name>A0A8J5MLN1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activating signal cointegrator 1 complex subunit 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ASCC2-L</name>
        <name evidence="3" type="ORF">Hamer_G012144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLN1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14364">
        <property type="entry name" value="CUE_ASCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041800">
        <property type="entry name" value="ASCC2_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF0">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="448"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7155989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="864" mass="97443" checksum="2D451A5797BA23C3" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MM69</accession>
    <name>A0A8J5MM69_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MM69"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035290427" evidence="1">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="78" mass="8902" checksum="046F4AE47C155CC2" modified="2022-05-25" version="1">MLKTILVACLVMAAVVVVTANPQHFNSQWYPGLQQGWGNNFFNHNPGYGYGGCRYWCRSFYNNNYYCCSSPNQQGGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMI7</accession>
    <name>A0A8J5MMI7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G030917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038353">
        <property type="protein sequence ID" value="KAG7156859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMI7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="376" mass="42597" checksum="348CBD9AF845A022" modified="2022-05-25" version="1">MKDRRNYTDKELINDMIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERREATPRPPPPTCTLLTPPQPRPRPPPTPTTPRPPSTPTTPPPPPTPTTPCPPPSPTIPRPPPTPTTPRPPHTVTKSSYPPILLLLTSPHLLPFLIASQRSSIVSRRRIECPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMR8</accession>
    <name>A0A8J5MMR8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inactive pancreatic lipase-related protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Pnliprp1-L</name>
        <name evidence="8" type="ORF">Hamer_G020275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038254">
        <property type="protein sequence ID" value="KAG7156995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMR8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035156838" evidence="6">
        <location>
            <begin position="21"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="7">
        <location>
            <begin position="78"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="7">
        <location>
            <begin position="347"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7156995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="522" mass="58286" checksum="EB53258940388018" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNP1</accession>
    <name>A0A8J5MNP1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dual specificity tyrosine-phosphorylation-regulated kinase 2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Dyrk2-L2</name>
        <name evidence="8" type="ORF">Hamer_G020350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036764">
        <property type="protein sequence ID" value="KAG7157807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNP1"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF130">
        <property type="entry name" value="SERINE_THREONINE PROTEIN KINASES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="222"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="571"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="751"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="811"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="862"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="862"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="881"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="937"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1035"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1056"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7157807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1067" mass="121064" checksum="446E003A5A03D025" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNS5</accession>
    <name>A0A8J5MNS5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Carboxypeptidase D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Cpd-L</name>
        <name evidence="14" type="ORF">Hamer_G019777</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036095">
        <property type="protein sequence ID" value="KAG7157912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03858">
        <property type="entry name" value="M14_CP_N-E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000020">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1120:FF:000004">
        <property type="entry name" value="Carboxypeptidase E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF62">
        <property type="entry name" value="CARBOXYPEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035216333" evidence="12">
        <location>
            <begin position="26"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1832"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="13">
        <location>
            <begin position="47"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="13">
        <location>
            <begin position="724"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="13">
        <location>
            <begin position="1449"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="597"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="698"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="639"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7157912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1930" mass="213489" checksum="4F7D2707339B248B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNW8</accession>
    <name>A0A8J5MNW8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidoglycan-recognition protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Hamer_G019449</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035076">
        <property type="protein sequence ID" value="KAG7158436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNW8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017331">
        <property type="entry name" value="Peptidoglycan_recognition"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF41">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037945">
        <property type="entry name" value="PGRPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0391">Immunity</keyword>
    <keyword evidence="2 6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="8">
        <location>
            <begin position="25"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7158436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="193" mass="21921" checksum="9681F7F7E0FE27B2" modified="2022-05-25" version="1">MSEKDYYFIPARACISDMGGKVSSVELVYREEWGALEPKSLTQLNPPMSKVIIHHTAAGKCTTKEECVEEVKKTQRVHMYCNAWDDIGYNFLVGEDGRVYEGRGWYTLGSHSMGHNTSSYGICVMGNFMEELPNDKALSALKEFINYGVQKGKLTEGYELFGHRDAQATDCPGLMLYNHIQTWSNFSHRNLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPA4</accession>
    <name>A0A8J5MPA4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="11">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DTX2-L1</name>
        <name evidence="15" type="ORF">Hamer_G011495</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the Deltex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="11"/>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPA4"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09633">
        <property type="entry name" value="Deltex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.130:FF:000001">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase DTX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039396">
        <property type="entry name" value="Deltex_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039399">
        <property type="entry name" value="Deltex_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039398">
        <property type="entry name" value="Deltex_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12622">
        <property type="entry name" value="DELTEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18102">
        <property type="entry name" value="DTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00678">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WWE" evidence="14">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="14">
        <location>
            <begin position="79"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="581"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="164"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="441"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7158813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="793" mass="88544" checksum="E9EDCC9F056AA7E4" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQ15</accession>
    <name>A0A8J5MQ15_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Post-GPI attachment to proteins factor 2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PGAP2-L1</name>
        <name evidence="10" type="ORF">Hamer_G004210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PGAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQ15"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039545">
        <property type="entry name" value="PGAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892">
        <property type="entry name" value="FGF RECEPTOR ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892:SF11">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="9">
        <location>
            <begin position="13"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7159563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="246" mass="28153" checksum="800802EC95C35D23" modified="2022-05-25" version="1">MTESDAVVRVSVARLAVVTVSLPLGAFFLCIYLSLRFNFDLSTATHCGVPNYLPSISSAIGEFVPQRYIWRAAIAVHCAPRFLVASMYYSFMNRILPNVAFYRNAVKVTTLLNVVENVALLSLSFVSSKENYDVHKVSFILFMVCSELYMVLTCLLLKDNARRFTTPLERLAFVKKKQLMTANLASFVIALYFFYRHNKYCEPGMYSVFAFMEYIVVLTNMAFHMTAYYDFHNHDLVVCEWKTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQX8</accession>
    <name>A0A8J5MQX8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G001907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQX8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7160613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="263" mass="29576" checksum="7148853852B11D2C" modified="2022-05-25" version="1">MWKTDNMKVNAPRTIKAHLGDMEAEGAKRMFGRSQDLKFRYENFVGDGDSGAYNAVITMGNGNGPYQSVQVKKLECINHVQKRMGTRLRKLRDEEMEIRTKTGVQNKLSDKAIDTLTSYYGNAVRSSAGKSFRHEDDSNERLPPSTDGHCQHGLSSEGSDSCCCFFQRGLAEGKGEEGMWTHALKTKFVGLHRAQFVAKTVILDHNYGYQDASLLKAMKKDSLALEKSLKDQDVIRQRHATLRARPKRKTMMKSTPGYARGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MT39</accession>
    <name>A0A8J5MT39_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box only protein 28-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Fbxo28-L1</name>
        <name evidence="4" type="ORF">Hamer_G004337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MT39"/>
    <dbReference type="OrthoDB" id="5860767at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22100">
        <property type="entry name" value="F-box_FBXO28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039719">
        <property type="entry name" value="FBXO28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="11"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="231"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7163235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="499" mass="55383" checksum="C07860E5FE2C1E49" modified="2022-05-25" version="1">MKSRMVGKGSYLNFLDLPEIVVEKTLSYLAYEELSHLRIVCKRFNQMNQMLLNKGFRRVERYQAKCLKEVKSQLPRRESERRNHPLSRHCDILTAIETRLSLLNMTFNKYIDCHMCCFIPGKVIDEIYRVLRFIQSNKTLPRTTEILTELRDISSMAMEHFEEKIIGPLKLTPLTPSSPRFSLSTPYSSFSPLSSSPTSSTAGSSLNKSLATPSSSTEDSPHLFASYKNTISTLKKEVSDMKSKFNEMRRKVSEQERVALEQNRILSEQTVKLTSQEGKLTEVNRKLLEQEQRFSEVLADMARMKEDSNGGSSSSSSSSSSNSNNNNNKTDGNWPREEKNQQFYGSPNIAAPTIGSTVFVAANMMQPNLLPVNLTPGQLSSPAYLTPPMQGYSSGGIALGMSPGHAASSTTSYSTCVMSQSSSLGTSPGRQISFPQSPSSVHDPSSSTTQGEDSSPSTSQNVCEVAASSGKSHGKKYKKRKLSEEEGFQDTPQAKWTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVI3</accession>
    <name>A0A8J5MVI3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024564">
        <property type="protein sequence ID" value="KAG7165201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVI3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69349">
        <property type="entry name" value="Phage fibre proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="547" mass="61773" checksum="98A4179F0BA72A22" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVU8</accession>
    <name>A0A8J5MVU8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVU8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="64" mass="7398" checksum="25C0F15EA4A3D3AE" modified="2022-05-25" version="1">MWHLINKVVKKKFFSALHHSPEEYAQDLVGTWSGQYQAVISRSTFTRPSPPIQISTPPASWRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWF2</accession>
    <name>A0A8J5MWF2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450 120-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Cyp120-L</name>
        <name evidence="6" type="ORF">Hamer_G011012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWF2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF252">
        <property type="entry name" value="CYTOCHROME P450 26B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7166191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="460" mass="52539" checksum="6AA1545B123C3F6E" modified="2022-05-25" version="1" fragment="single">TNRWLRNTDEVVGPHSVSLYLQIMSGEDDIVNHNMRCTRIDSQNNVQKHEVISKTLPGTSGWIWSDHTLAIYQNAQAFVEAGIKQHNSRIFLTRLFLKPCVVVADNQALLELLTEKEDHYEAGMDEYYDLFGDNLLFMNGPEATLTRKLLYPLFNEESKSGYKAITKDLVETWISELDASKPFNVYESTKHFALLLNLRLYLGLDHNKEPQLVEQFSSVATTHWHGMCSLPVNIKVPGLKSGFGQGVDAKDELLLLLREPFLVNMSESIPSEELQLNHLLVCCCAIIPKVFASVLTSFILMAPSWKPYYQTCSSEEEKEAALDKILLEVMRLLPPTTGGRRVARRDTQLKGYAIPSGMVVHFSFFGAHTDPAVFPEPNKFRPERWVEENKNDRCRMFAFGAGPRECIGKKMIWDIILIFCKAFVHKFEWEVSGDHLKQLKFIPAVRPKKKPHIQLLTKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWZ7</accession>
    <name>A0A8J5MWZ7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G011953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7166024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWZ7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="100" mass="11926" checksum="EF7E12CDB4CBBBB0" modified="2022-05-25" version="1" fragment="single">MIQTDTGLFLFPPDVWVERVRPVLAQNWNFQLLKKKMWVFRWHHLCFTYDHKRHLISTYVDGSLNNHQEYDIIRTMSAARARLGQGYTPERSFSGDLTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXR1</accession>
    <name>A0A8J5MXR1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Alkaline phosphatase</fullName>
            <ecNumber evidence="3 17">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Alpl-L2</name>
        <name evidence="19" type="ORF">Hamer_G010215</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3 17"/>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXR1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000008">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="9 15 17" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035235203" description="Alkaline phosphatase" evidence="18">
        <location>
            <begin position="25"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="14">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG7167813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="533" mass="58753" checksum="C3FACFB2D5D8E265" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZ96</accession>
    <name>A0A8J5MZ96_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G028747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018920">
        <property type="protein sequence ID" value="KAG7168802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZ96"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="102" mass="11994" checksum="299A2F0EB99B7204" modified="2022-05-25" version="1" fragment="single">MKTLRPAIPTDKKEPTFKTMRIALDEYFGDKTNELFERHKFRMLAQEVGESTHNYVTCLRTQGAKCNFDNYNLDQAIIDQLTEKCTSHKMRRAYLKETDITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZC4</accession>
    <name>A0A8J5MZC4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015772">
        <property type="protein sequence ID" value="KAG7169583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZC4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF1">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="455" mass="51352" checksum="5784F3C2AEBC0BB6" modified="2022-05-25" version="1" fragment="single">EQTKANFHHHEQTNTTQDKFLQDVKALTLKWEEIADIMALHTKEILCPEAVKSVQNVVKLAREQFHSYLADKITDAPHVTSIILDEPAVVEMLKPGGSRTFQEYSTAVFIPYIESQLEYRSRLDLVWDCYLKSGSLKATVRCNRGKGIRRRVTVSGPLSSNWQNFLRNSDNKEELFSFQSEQVVQLVIKESKQLVVTDKKQVLTVPPRKDTANLAPCNHEEADTRMMVHAADALECGHRRVLIRNVDTVVVILAITLANERSEVLDELWLTFGTGKNRRYRAAHQIAKALGPEKSRALPVFHAIADCDTVSAWATWNAFPEVTTAFLSLASTPSELPDGVLSTLERFIVLLYDRTSTCCDVNMLRKKLFSRKSRSLEDLPPTRAALEQHIKRAAYQAEHIWGQASIAFVSLPSPCDWGWMKSGDELEPHWTTLSEVSKSCHEPISCGCRKHCGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZG5</accession>
    <name>A0A8J5MZG5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Armadillo repeat-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Armc8-L</name>
        <name evidence="7" type="ORF">Hamer_G011638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZG5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7168952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="633" mass="70091" checksum="6FAA1D3AD503DC7B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZV3</accession>
    <name>A0A8J5MZV3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Metalloendopeptidase</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BP10-L4</name>
        <name evidence="13" type="ORF">Hamer_G022041</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="EMBL" id="JAHLQT010015988">
        <property type="protein sequence ID" value="KAG7169551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZV3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="12">
        <location>
            <begin position="54"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="11">
        <location>
            <begin position="303"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7169551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="422" mass="47836" checksum="083CF257BB8A3EA9" modified="2022-05-25" version="1">MSLYQDQEEVSPALKMNANIGFEFTNPDTVNGKELFEKDLMLTPEQWHAIRERKAISNVIFRWPPGPNGYPLIPYRFVDPVNRQAVEDGIKHWMEHTCITFEETFNTNQPHLQLIQGSGCWSYVGRVYYWNGQDLSLPPSCTGFGVVVHEIGHAIGFWHEQSRLDRDNHVLVILDNILETRQSNFNKLNNANAYGVPYDYTSVMHYGDTYFTKNGNLTIATTNPLYQELIGQRGGLSHYDKLLANLIYNCTDMWMSNCGLRSDPCENYGYIGADCRCVCPSGTSGDNCTLVTSDYYDDKFSSCTEVITQPGTITSHPDYPDNYEAGLRCTKVIKAPVCFLPVVTFNNFLIYGPLSNGQCYWDFLLIRTFNLSAGEMYCGSQISPGVSFTSTVDEMSLYFSTRTRLYNGWSANVTFVPIDGCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZZ1</accession>
    <name>A0A8J5MZZ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-binding LIM protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ABLIM3-L</name>
        <name evidence="7" type="ORF">Hamer_G016121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="7">Heart &amp; testis</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014436">
        <property type="protein sequence ID" value="KAG7170315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZZ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09329">
        <property type="entry name" value="LIM3_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09330">
        <property type="entry name" value="LIM4_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000055">
        <property type="entry name" value="Actin binding LIM protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000075">
        <property type="entry name" value="Actin-binding lim protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051618">
        <property type="entry name" value="Actin-binding_LIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213:SF9">
        <property type="entry name" value="UNCOORDINATED 115A, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="429"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7170315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="559" mass="62087" checksum="4C98C9A5A19E5EFD" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0W0</accession>
    <name>A0A8J5N0W0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012765">
        <property type="protein sequence ID" value="KAG7171185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0W0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="106" mass="11869" checksum="3F77C81DFC9403D5" modified="2022-05-25" version="1">MNQVLETVCNIPAPGFQEVTREDLEEPMQEGNTNDVEDLLEDEEGSDAASDAGETEQRKVTTQKLSLLLGVCTSLQEMIQDIESESGEREQMIGFVESISRKYQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N293</accession>
    <name>A0A8J5N293_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ribonuclease P catalytic subunit-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Prorp-L</name>
        <name evidence="2" type="ORF">Hamer_G000843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N293"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031595">
        <property type="entry name" value="PRORP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16953">
        <property type="entry name" value="PRORP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRORP" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="176" mass="20976" checksum="183180A96191E99F" modified="2022-05-25" version="1">MFDMLRDHLFRLEQVPLRETFRRWQRLHQIMVIKTHIGFHLLDPAAFSTTAQQGKGGWHIPYDDGTPHQSYQVPRTWLCLQSTLPQRKRQYFQPENSNDDKFEDLSFEYKGNKSRRTNLDQKESKWSSELRISSSDTNLEFTRKHSRPWRKNTGRIDVKKINVSTLADILNTNNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2N7</accession>
    <name>A0A8J5N2N7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2N7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="113" mass="12379" checksum="B73759F23CD9D0DC" modified="2022-05-25" version="1">MDTVEAVREQLDYDTRPNAQDLICPALDNGMEEYKALYMSCVNARQQALITGYLCKNQPVNALANITLGDDDGTTDDDNEVLGDLLVEELPQDLEGFDAEVRGGVEEGPGKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3Y3</accession>
    <name>A0A8J5N3Y3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Solute carrier family 25 member 51-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Slc25a51-L</name>
        <name evidence="13" type="ORF">Hamer_G006984</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3Y3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052465">
        <property type="entry name" value="Mito_NAD+_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131">
        <property type="entry name" value="SD08549P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131:SF1">
        <property type="entry name" value="SD08549P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="50"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7172752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="286" mass="32137" checksum="F7E09A1741BABA53" modified="2022-05-25" version="1" fragment="single">GLSVVEQDHSSGLPPSLGAVLPKQSADKPAFTMPDPASTSQALARVTPLADDGREFVCGWGAAFINITVTFPMNKLMFRQNTHCIFPLQMLHGISTASAVKQLKREGLKNLYRGILPPLCQKTISTSIMFGMFDQYGKLLKYYQPQLSDDMMRQAVEHQCRSTHESVWVVRVVYVLPLVCVVVLLLPECYRLIVNSIHTTREMWKFGVKEYYRGMVSILLRNGPSNILFFGLRTEVKTRLPDPGRSWWGHILSDFVSGAFLGAFISTVMYPINVIKAHQQTQVSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5D1</accession>
    <name>A0A8J5N5D1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009070">
        <property type="protein sequence ID" value="KAG7173675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5D1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="635" mass="71520" checksum="2BA352079CBD6D72" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6E3</accession>
    <name>A0A8J5N6E3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 256-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Tmem256-L</name>
        <name evidence="7" type="ORF">Hamer_G003368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM256 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6E3"/>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7174425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="165" mass="18399" checksum="404F5A9D033EC7EF" modified="2022-05-25" version="1">MVGDSYGWLWNNPLTREVARCPKRVGDLIWSEKKGSSIQQVTPLLVDMLNIPSYARWFVRIAGISGATAVALGAYGAHVFYRREYPEELKQVYETANRYHFLHTLALLGVPLCKRPKLAGALIATGTAIFCGTCYYYALTGSKNVRQYTPYGGMLLIVGWLSMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9X7</accession>
    <name>A0A8J5N9X7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G009760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9X7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="123" mass="13899" checksum="3A523FCDF738A9C7" modified="2022-05-25" version="1">MSVSSLPVIIITASITVNDILTIQLTRFVEDAIVWESFVGHGRFSSILQGLVIILATQVEARYYRGFKGMFYTPSQHPARPTDPHNGASYLWWGGSLLLLLIQAKKSYPRRLYAKMDVSLIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NB10</accession>
    <name>A0A8J5NB10_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein argonaute-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Ago2-L1</name>
        <name evidence="12" type="ORF">Hamer_G008998</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the argonaute family. Ago subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NB10"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000001">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000001">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000005">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PAZ" evidence="10">
        <location>
            <begin position="287"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="11">
        <location>
            <begin position="563"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="867"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7176231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="905" mass="101152" checksum="5BFAFB2F87646A08" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBA6</accession>
    <name>A0A8J5NBA6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fizzy-related protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cdh1/Hct1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Fzr1-L</name>
        <name evidence="13" type="ORF">Hamer_G009110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBA6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000025">
        <property type="entry name" value="FIZZY-related 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="12">
        <location>
            <begin position="126"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="386"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
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            </authorList>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF7">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="54"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="236"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="333"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7177304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="401" mass="43765" checksum="B98BB681BFD4A566" modified="2022-05-25" version="1" fragment="single">MSWARLMLQQLEINFYSRRTLVLATIKRGDGFQQMLERISPLKLYTVCPKNYAHNSDLQLSAGADYIKASWLKEFKATSYSINWTPKDHGGTYTMDGGNNISYTITDLQPCTDYTVTVQPMKNSSKEGLPLTATTTTTIADPDPKLKVVTVKSQSSTQLFVNWTAAQGVGNCCVTYLITWGPASKAHGGGSATTTSLNYSITQLDTWTIYHVCVAAQTRTDYNKDTCADGRTDEDAPGPPVITSVVSSSFSSIRVSWSSPENPNGIITKYNVSWTWEGNKDHDITNDTTTSCTITDLTPCTNYSVTVTATTSKGYGPESKAATGTTHSKDPDPVTGVNVNNYTDNSTLLDVSWSEVQDVGNCDVTYKITWSPASNGDGSNTTTTTSLSYIITQLEAWTTYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCY9</accession>
    <name>A0A8J5NCY9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCY9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="86" mass="8656" checksum="310ECA1DFC942C9B" modified="2022-05-25" version="1">MMGGKRWVLGSKSLRAAARTDIAKGREPTHTHTHTQLGSSPPWCGGSPGDAGTARVVSPGGGSGDGLPGEQQGGGGNRFTTLQEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDP4</accession>
    <name>A0A8J5NDP4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Ankrd44-L1</name>
        <name evidence="5" type="ORF">Hamer_G000571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDP4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="485"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7177281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1179" mass="126989" checksum="A2EA8D8B12FB5753" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NGR2</accession>
    <name>A0A8J5NGR2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001055">
        <property type="protein sequence ID" value="KAG7177926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NGR2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="136" mass="14880" checksum="F3AB4E60CBA1EB54" modified="2022-05-25" version="1">MLRACGGGAKVMVVVGVVRLCRGSSSSSSGMYQGHPKNGSWSRRSSQGGINCVFRCVSTVLALVRSTPFVSPFRQRGYDQRRLPLRHTTLPVCGLVTVTPLWCIYGSSWVLPYNEVYNNHTVRCSGRGGQRGSELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T2R7</accession>
    <name>A0A8J5T2R7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T2R7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="109" mass="12909" checksum="58E546E0D304AAC7" modified="2022-05-25" version="1">MTEYKLVVVGVDFRTLLKLHLALVRPYLDYTVQFWSPIPRKNSEENLEYRDRLKHLNLHSPRDVYKWKSGLNKGGITKWNKFPNIIINSNLLDSFKHRSDGYMSNSGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TE83</accession>
    <name>A0A8J5TE83_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Lectin C-type domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G017781</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007950">
        <property type="protein sequence ID" value="KAG7174060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TE83"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035172914" evidence="1">
        <location>
            <begin position="22"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="127"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7174060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="257" mass="29124" checksum="66DA2E8F3F4C8903" modified="2022-05-25" version="1">MSQRGKLRLLTLTVVLTGVLCTNQNKFLEFTGYYIQGHVLIRLQSASLIQCASVCLMNQPDCRAFNIIYKRRPSREYICEVLSSYSHLRVLLHSTLYYDPNMYQELGYKLDLGRLVHYIPPASTGISWGDAKAACKSLWGELLVPRTQLEWEWMKIIYNNMNYQAMWMPILETPGDLAMTWTNDGVGSAKCWTGDAYSKDCDTVDCGLYSDQSTITASFDVVIKDCYKGSLYTGIGYICEAAIPEPATYTLNQIFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TI32</accession>
    <name>A0A8J5TI32_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G018099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007025">
        <property type="protein sequence ID" value="KAG7174780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TI32"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF1">
        <property type="entry name" value="TESMIN_TSO1-LIKE CXC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="422" mass="46974" checksum="40CD4FCF92C69A91" modified="2022-05-25" version="1">MAALRKAGSWLQGSGWAETLVQADVASQGTANSFLKAAHVTRTRRGHQITAATLNILQHKAYGKYTENAQSDGHEPLEFGVWCHQRAECCPQFQYWATTLNLEQSIFMFLADEITDTPHVTSTILDGPAVVEMFKPGGSRAFQEYSTAVFIPYIESQLEYRSRLDLVWDCYLKSGSLKATVRCNRGKGIRRRVTASGPLPSNWQNFLSNSDNKEEVFSFLSEQVMQLVVKESKQLVVTDKKQVLTVPPRKDTANLAPCNHEEADTRMMVHAADALECGHRRILIRTVGTDVVILAVALANEWSEVLDELWLTFGTGKNRRYIAAHQIAKALGPEKSRALPVFHAIMGCDTVSAFAGHSKKAAWATWNAFPEVTTAFLSLASTPSELPDGVLSTLERFTVLLYDRTSTCCDVNVLRKKLFSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TK52</accession>
    <name>A0A8J5TK52_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="2 11">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DOT1l-L</name>
        <name evidence="13" type="ORF">Hamer_G015417</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="2 11"/>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TK52"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="12">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU271113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7176611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="209" mass="23273" checksum="8CA8A01CB62B701A" modified="2022-05-25" version="1">MKWVCGDIPELKRAMEEKGTSLPATRLNKRPSRGMLKHILTQIYNHAVVDPEKLNQYEPFSPEVYGETSFELICQMIDQIHITEDDMFVDLGSGVGQVVLQMAALTSCKICVGIEKAETPCKKSIGKESPVLPSSSSTTLPERRPHVKEVFADLRTGLVLSHIGTIMHVSELSPLKGSVSWTGKPVSYFLHIIDRTKVNARLENLCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKQ0</accession>
    <name>A0A8J5TKQ0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Perilipin-2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Plin2-L1</name>
        <name evidence="4" type="ORF">Hamer_G000360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the perilipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKQ0"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010890">
        <property type="term" value="P:positive regulation of triglyceride storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004279">
        <property type="entry name" value="Perilipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024:SF49">
        <property type="entry name" value="LIPID STORAGE DROPLETS SURFACE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024">
        <property type="entry name" value="PERILIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03036">
        <property type="entry name" value="Perilipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7177121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="342" mass="37730" checksum="310B6773B4D68FB7" modified="2022-05-25" version="1">MLDGTDHREATATFTFITRLQALPAVQDALAMATRLYHTTKDYKCVGVVVGVAEGGVRAAAAVLPLATPLTKPILQRVGGWEAVDEWACRGLNTVEEWVPVLRKSPREVTEQVVTSTKEKVLSVVAGTDTVPPPTLTAALTARISHTVSVVSETRGGRTVVWVTEEVLAKAHTLVDHYMAPNACDLHDSDGREGGVVVKASTLGQKTIRRLYRITHDFVHPNSEDCNDTSATHLVARAGESAREWYATTTQDQRLQVEGMSMVQISVRLAVRTTHHLVLSVRFFLDLSPSQVTNMVLNYSAGVAERTTMLMNLLMQQLKVFFIILELYALRFRLKSIQLKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TL86</accession>
    <name>A0A8J5TL86_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G024784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002875">
        <property type="protein sequence ID" value="KAG7176745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TL86"/>
    <dbReference type="OrthoDB" id="6358245at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="379" mass="42675" checksum="F8F4B7E9EF629FA4" modified="2022-05-25" version="1">MKSPVPQDAKTFVTWWTMVKEKPSLMTKAKQKLGSWELVEEHFQAGAWEAVVGLALHTSPETTHITLTEDRPWDLPGLLPVLTALFKVDCDCVVDWRRDWRLESAKGSITPVMAALLQCSKPSTVEVILPDDQFSSNLSALPAILDRLAHTSCSLNILLEGDFLAQNDFYISDYLLLPLLDGKARVRLRRLSCHMDVEAAEKFFQEDAQNDSSDEDFPGVRHRPMFHATPSIRYLEVLKIRISSLETIVALNRSLPLLELLDELEIHLTLQGFVFSEDIPQLCYTRDKLTLRLNRITDARAEWAGRVTAALSNQYAQVWLCWCYMTAAGGEVFLDQLKINRTLVGAVHVFALSGRPCASEFSSLSTKAALLATHTALYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLF3</accession>
    <name>A0A8J5TLF3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleic-acid-binding protein from mobile element jockey-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gag-L1</name>
        <name evidence="4" type="ORF">Hamer_G003915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLF3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7178139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="257" mass="28799" checksum="4A6350B8E618969B" modified="2022-05-25" version="1">MVLLGYPLELPVEVIIIHPKVTKAKRCVTTRDKAQTKQVLVDIKGTVPEEVDLGNWGTYKLHPFVPEPLRCYKCQKFGHHQSRCHKKVKCGNCSQSHKTEKNVKKHKEGTTTTAKCPNCGKKHYAWSTSCPERRERMKAAMRKIQPQNITKAPQSTFVWGQQRQKTVNPTPTPPQLSGDSFPVIPLPGDRTKLKTPGQNLSMQETMTNQWTPQPQLKSCKSVIAQNTPGLVENTKLPGTLQPPQATTQLNTPQPANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLY5</accession>
    <name>A0A8J5TLY5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Forkhead box-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLY5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7178126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="60" mass="6648" checksum="A2A8983F732F41DE" modified="2022-05-25" version="1" fragment="single">MGGESTSFTQGQVIVQTSADPNSFTHTQVILPTPHQIWLWQVAIVHNNFRGSSGCFTLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TN07</accession>
    <name>A0A8J5TN07_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vigilin-like 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">vgl-L32</name>
        <name evidence="4" type="ORF">Hamer_G029001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005596">
        <property type="protein sequence ID" value="KAG7175547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TN07"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="193"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="272"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7175547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="347" mass="38605" checksum="D6AA882FD81666A5" modified="2022-05-25" version="1" fragment="single">MKVNQERSRPLPPSMSRMRAQWVEETVSETVKADNCLFGVIIGPGGSTIKELQVKYNIRVLVPRKGSKDEPITVQGKDKTLVKNAVLRIKALIAEEKERRRVTTPVSQTLCIPKALHGKVIGLQGQNIRPITQALKIKIQFPNKNDNSDEVTLTGLPDQVDQGISRLLNLVNQERSRPLPPSMSRMRAQWVEETVSETVKADNCLFGVIIGPGGSTIKELQVKYNIRVLVPRKGSKDEPITVQGKDKTLVKNAVLRIKALIAEEKERRRVTTPVSQTLCIPKALHGKVIGLQGQNIRPITQALKIKIQFPNKNDNSDEVTLTGLPDQVDQGISRLLNLVTRFPPCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5IZT6</accession>
    <name>A0A8J5IZT6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2 S</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme S</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein S</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin-protein ligase S</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Hamer_G010608</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5IZT6"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010458">
        <property type="term" value="P:exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000034">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="13"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="14">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7153312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="207" mass="22539" checksum="0EF4B3238CC89E6F" modified="2022-05-25" version="1">MASTSNVENLSPQILRGVMKEMTELVKGPPEGIKVHMNDEDITDIQATIAGPAGTPYAGGMFRVKLALSKDFPNVPPKGYFLTKIFHPNVASNGEICVNTLKKDWKADLGIRHVLLVIKCLLIVPNAESALNEEAGKLLLEAYDDYAARAKMITEIHAQGPKVCKGEPSGEGTSQGGPLTKKHAADKKITADRKKLLKDKKRTLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J878</accession>
    <name>A0A8J5J878_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Reticulophagy regulator 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RETREG3-L</name>
        <name evidence="8" type="ORF">Hamer_G018163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044460">
        <property type="protein sequence ID" value="KAG7154427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J878"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052114">
        <property type="entry name" value="ER_autophagy_membrane_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057282">
        <property type="entry name" value="RETREG1-3-like_RHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20952">
        <property type="entry name" value="ADP-RIBOSYLATION-LIKE FACTOR 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20952:SF4">
        <property type="entry name" value="RETICULOPHAGY REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24456">
        <property type="entry name" value="RHD_RETREG1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="RETREG1-3/ARL6IP-like N-terminal reticulon-homology" evidence="7">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7154427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="340" mass="37179" checksum="F6A0B2CCE737CD21" modified="2022-05-25" version="1">MWRFGILFVGQFCAIVTTVLSVGAVVGHMVPGAVLVYILLMVVVTGPGVVLHVLPDSFYERINRIRSALRGDDSGMELQSLEAQAALDVPLMSQDPPEVEQMMEEAETLREAARESSTRKRSRKGSKGAGEASAAAQGLSLPLVTGEDGNTTCFTSGLPQDFPSYDHESVEDLDGPDLDLPELPHPVPEPRQERQGPGGDRYQMQFVSSHFGESSDEEDAFIEGLTFEERSQIRQEPLYPQSYPPNELPITTTMDPIGQLMSSVIAQNAGNVLSALGQNLVTSVIGQSTAIAQPVPTTSQQQPRRQQQPPARMTRSHDPNQQSTTDLEEDFELISDEEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J9G5</accession>
    <name>A0A8J5J9G5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Ptpra-L</name>
        <name evidence="7" type="ORF">Hamer_G010705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J9G5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="19"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="124"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="302"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7153393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="411" mass="46210" checksum="698C127E7D8D71A2" modified="2022-05-25" version="1" fragment="single">VIQYQYIAWPDHDVPQTPFSFALMVQDICKWNTTGPIVIHCSAGVGRTGTLLLVLTLLDQLEGSGQLDAPGSLVSLRLGRPNLVENQAQYRFGHQVLLEVLFSEVTSYPVGKFLSYLEAIRDNLIAQYTKLKSLPRDLTFKWGENPAHAHMNRRQSILPVDGRQVFLQMLGGQAESQYVNAVRVNGVTQRDAVIVTEHPLVHTLPQVWRMVYERKVCAWVILHTYPDQEEEYPSVLPSRGEVDMDQVCVKVTAVNNHRHFIETSVALNFINSSILLPHHLRVLHLLGWDADQDLPDSPVPLLKLLEHLKDLRKIYPNCPVLISCSDGCTASGVAAALDVVLCRARLQGNVDVYRAVQGVLFDRPQFIMSFEQYIFLHDAAATYVNMLDDDDDDDDDDETISDSQICVLGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J9T8</accession>
    <name>A0A8J5J9T8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcription-associated protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G009307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J9T8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035319432" evidence="2">
        <location>
            <begin position="17"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7153648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="150" mass="16628" checksum="248E385ECABE907C" modified="2022-05-25" version="1">MKVLACVVMVMGMTQGASLSNPKASLSIKDKLALDLPLKYVSESTKAPTKLELVKVSFPSTTTTTTTTTPEPQRNTERPQYIDATVFRHQFTRPNTETEPPQPLVDGRSFDYEAHFRLWDDLSSFAGEMGPLGGDLRGEEYIVGFRPPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JAY7</accession>
    <name>A0A8J5JAY7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger CCCH domain-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Zc3h14-L</name>
        <name evidence="12" type="ORF">Hamer_G017702</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046276">
        <property type="protein sequence ID" value="KAG7153881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JAY7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.30:FF:000001">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="821"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="821"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="124"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="374"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="568"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="131"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="191"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7153881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="989" mass="110796" checksum="75373DE8B01046F0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JC24</accession>
    <name>A0A8J5JC24_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Ptx-L1</name>
        <name evidence="13" type="ORF">Hamer_G018159</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044460">
        <property type="protein sequence ID" value="KAG7154424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JC24"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016233">
        <property type="entry name" value="Homeobox_Pitx/unc30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882">
        <property type="entry name" value="PITUITARY HOMEOBOX HOMOLOG PTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882:SF3">
        <property type="entry name" value="PITUITARY HOMEOBOX HOMOLOG PTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000563">
        <property type="entry name" value="Homeobox_protein_Pitx/Unc30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="12">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="37"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7154424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="277" mass="30497" checksum="D0CA1A79E0F4C675" modified="2022-05-25" version="1">MPPQYTNILSLTTDGGEKPSQSCSTESDDDKNKKKRQRRQRTHFTSQQLQELEATFARNRYPDLSAREEIALWLNLKEAQVRIWFKNRRAKWRKRERHAMTAGMPGDLKGGWGAQLNGLAWPDDGLYSGYSYNNWAKVTPPPLGAKSFTWGFNGVNMNPLMSQQPSAMSPINCFQTPTQSMGGSANLMPTSMSSSLGSSAAPCPYPAPTPPYVYRDQTSSMSSSIASLRLKAKSHSPAFSYSSGGTDTRSPPAPDNNAFFTTAGPTDKFSCMNTVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCE0</accession>
    <name>A0A8J5JCE0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 9">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">UGP2-L2</name>
        <name evidence="10" type="ORF">Hamer_G019863</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19890"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 9"/>
    <dbReference type="EMBL" id="JAHLQT010041650">
        <property type="protein sequence ID" value="KAG7155445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCE0"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7155445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="487" mass="54497" checksum="39CA0348F7A39D08" modified="2022-05-25" version="1">MSVAPPSTLPRNYDRYNEVFGHNRRPSVEFKNLTKRDAKVQLAQELQKLLHTCPQYLREATQKEMESFEKLFGRFINEAGPSVDELESPKVSSVKSMLDKLVVVKLNGGLGTSMGCQGPKSIIPVRSDLTFLDLTVQQIEHLNKTYDCNVPLVLMNSFNTDEDTQKVVRKYQGFQVKIYTFNQSRYPRINKQSLMPIAKTCASDDSFEGNSGLLDNFINEGKEYVFVSNIDNLGATVDLNILNFLLGGHHPAQCQFLMEVTNKTRADVKGGTLIKYEDKLRLLEIAQVPKDHVDDFKSVKTFKIFNTNNLWIKLTAMREVLAEGTVDMEVIINNKTLDNGLNIIQLEQAVGAAIKSFSGALGINVPRSRFLPVKKTDDLLLVMSNLYRLQQGALTMSPLRMFDTTPLIKLGSSQFGKVKDFIKRFSSIPDMLELDHLAVSGDVTFGRGVVLKGTVIIIANHGERIDIPAGAILENKIVSGNLRILDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCW1</accession>
    <name>A0A8J5JCW1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposable element Tcb2 transposase-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Tcb2-L4</name>
        <name evidence="3" type="ORF">Hamer_G021330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040102">
        <property type="protein sequence ID" value="KAG7156092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCW1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF134">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC1 TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="179"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="356" mass="39590" checksum="841DC86E3678B77B" modified="2022-05-25" version="1" fragment="single">MGPVSLFLLSSSSFQQPVCGLLITSLPSVCYLKAAKEIFTFLAQMKSLHGVQSKDFNCIPGLTKVGGACDHVTASHAPPATKAARISEPRALIERGANIRSSATRHSSHPISPPKLNRMGRNKLTLHEKARALTQLELGMQAIYNLKHAAAPLPPGAIPKRKVGSGAVRKTSIRTDNILKREVMSDPAVTASTLKKKHPDLLKHVAIRTVQHRLQKDLSLPTQRAAKKPLLTKAMKKKRINFCKKYQHWTSDDWKKVMFSDESTFRLVRGASKIVRRPKNVSWCSPKYTVKTVKHPDSVMVWGTFSGCEGRGGLYGLPKNVTMKGTNYIEVLRDHMLPFWPIHQCHHFMHDGAPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEQ0</accession>
    <name>A0A8J5JEQ0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038600">
        <property type="protein sequence ID" value="KAG7156837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEQ0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="88" mass="9878" checksum="AD2F0036B5E0BB40" modified="2022-05-25" version="1">MTSSGSCPSSSRGDKNSEQCQPARTLRVKNYDLYIKDKVEFSYNFFKISQNLTALSTDAFVETDFSIVQNIATFPPKAPETKTQEKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFJ1</accession>
    <name>A0A8J5JFJ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G010044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFJ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="128" mass="14462" checksum="5C84A6163C4B13C2" modified="2022-05-25" version="1" fragment="single">IGVGFCLKYGRILPLETVGFRLIRLDSAPEYEYGRIPSQNMVGFRPRIGYDSLYPEGFCPRKRILPQKTVGFRSRIGYDCTKNTEGFCPEETDSAPEYGRIPPHKTVGFRPRIGRILPQKTVDPAPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHZ4</accession>
    <name>A0A8J5JHZ4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GBF1-L</name>
        <name evidence="7" type="ORF">Hamer_G019533</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum-Golgi intermediate compartment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046868">
        <property type="protein sequence ID" value="KAG7153474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010256">
        <property type="term" value="P:endomembrane system organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000007">
        <property type="entry name" value="Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
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        <name evidence="3" type="ORF">Hamer_G006235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJJ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSMD12/CSN4-like N-terminal" evidence="2">
        <location>
            <begin position="62"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="323" mass="36729" checksum="17794E99208EDD64" modified="2022-05-25" version="1">MSSEKKPTEKKPVEAGGTEDSTLGNVISEGGRLVKMEVDYSTTCDEKIPAAQQMAKDGRVQEAVDSLMVLEKQTRTGADAHSTSRVLVAVVEICFDAGEWNLLNETVVTLTKKRSQIKMAVTKMVQKCCDYVDKAPDKDAKLKLMDTLRTVTAGKIYVEVERARLTHKLAVMKEAEGDITEAATILQELQVETFGSMERKEKVEMILEQMRLCLLKKDFVRTQIISKKISTKFFDSEEVDDLKLKFYNLMIDLDSHDGSFLSICRHYRAIYDSKSVKESETEKKRVLKHVVLFIILAPYDNEQSDLLHRIKEDKTLEDISQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JL15</accession>
    <name>A0A8J5JL15_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G021649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031456">
        <property type="protein sequence ID" value="KAG7160272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JL15"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="725" mass="80339" checksum="F2EE8071A1A4F78F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JM68</accession>
    <name>A0A8J5JM68_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G012744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JM68"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="58" mass="6453" checksum="A4CCB8D40BD3B4A4" modified="2022-05-25" version="1">MLTTVGFFDRVWGEGDVCPYAKIAPVGYIKEESWKLETLPSSGLVHRLTSAKVRDAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMZ5</accession>
    <name>A0A8J5JMZ5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclosome subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Cdc23-L</name>
        <name evidence="12" type="ORF">Hamer_G016660</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the APC8/CDC23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMZ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000093">
        <property type="entry name" value="cell division cycle protein 23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="11">
        <location>
            <begin position="47"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7159258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="583" mass="67581" checksum="3318A0AE501AF624" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNN9</accession>
    <name>A0A8J5JNN9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ZBED8-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Zbed8-L3</name>
        <name evidence="1" type="ORF">Hamer_G004224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNN9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF19">
        <property type="entry name" value="LOW QUALITY PROTEIN: ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="126" mass="14483" checksum="B40ADB476E33E5AC" modified="2022-05-25" version="1">MKSIEAKAMISYLADIFGKLNALNKELQGEQKTLMDCKTKMFGFISKLGFLKAHVLRNNLSHFPHLSKCVPSQNVLQIISENLSNLHDDLSDRFFDLKQINFPSWVAQPFLFTWENNDCLAKMESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNY6</accession>
    <name>A0A8J5JNY6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative xaa-Pro dipeptidase-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Pepd-L3</name>
        <name evidence="3" type="ORF">Hamer_G016323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNY6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501:SF5">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501">
        <property type="entry name" value="TRANSPOSASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13565">
        <property type="entry name" value="HTH_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="460" mass="51367" checksum="C43BD86197E1B33A" modified="2022-05-25" version="1">MEGEDVFVPPDDAGPGGPVDRVEEPAVAVSETAQAEGQAQESQSPWPHLDDYFVLKSRDKRNANILYFQCVICQPKETTIKGQATSLYNLKSHVKRKHPAHAIQFEERIKAGSSRGKHRQSSGSGASSRSSSQSLQPPAKKPRQPTIDEAFGQSAAGTGVRQSVVDKRIVDLFVCNMLPLHVVESPTFVSLIKTLNPSKTSMSRRTLGRRILASHKQLEEYLRRLKLYKFIALLYGITQSQESRSHRSLKSKAQNLVKTWLEAGSKEVLTDVAFLDFIEYIEKKATYSLELIDAIKTTFASHNTKASSSLLPDHLWSFFELVLVESNPMETSQATRISIITLHGVGLSNGEIARRIGVSKNTVALWIKRFEDTGTTMDQPRSGRPRCTSSEQDEAITAALHADPSATATSIREQHGIRCSPQTIRNRSRGKKSRELGLKKRKDYAGKHLWDNFWCSKEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPE1</accession>
    <name>A0A8J5JPE1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase 6-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">acdh-6-L1</name>
        <name evidence="11" type="ORF">Hamer_G010851</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPE1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF6">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="44"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="162"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="270"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7162182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="603" mass="68347" checksum="9AAC8DB5FCB522B2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ62</accession>
    <name>A0A8J5JQ62_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative CGG triplet repeat-binding protein 1-like 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Cggbp1-L19</name>
        <name evidence="1" type="ORF">Hamer_G030573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034046">
        <property type="protein sequence ID" value="KAG7159059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQ62"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033375">
        <property type="entry name" value="Cggbp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32344">
        <property type="entry name" value="U1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32344:SF1">
        <property type="entry name" value="U1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="269" mass="30208" checksum="923D73066551186C" modified="2022-05-25" version="1">MDVVDAMAYSYFSAGRSVEKLSQQYFATDPFAQNTVTASKKFQVQQHLKTSKHIRLEAVKSNSAQKEQQLLLACSSKSGPDRSQFNADLCKAFVSADIPLHKLNNKCLKSFLEQYTGKKVPDESTLRKNYVSQLFKDTMEIIRRKACGKKIWVSLDETTDVEQRCIVNLIFGVLGDETERGKYYLAPSRTARFSEIAPSTPLPPSPVVTRWGSWIDAATYYGKNFDVIEAVIATFDPEEAQSIQESKILLETEGIKESLLFIATNFACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQD7</accession>
    <name>A0A8J5JQD7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TOX high mobility group box family member 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Tox3-L</name>
        <name evidence="7" type="ORF">Hamer_G005682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQD7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21995">
        <property type="entry name" value="HMG-box_TOX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000005">
        <property type="entry name" value="TOX high mobility group box family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051365">
        <property type="entry name" value="TOX_HMG-box_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45781">
        <property type="entry name" value="AGAP000281-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45781:SF1">
        <property type="entry name" value="HMG BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="303"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="303"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7157284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="419" mass="45321" checksum="BBC446AE60B9C660" modified="2022-05-25" version="1">MVEEEGGGIYTMQGPRPVSAYALFFRDTQAAIKGSNPNASFGEVSKIVASMWDSLDADHKNVYKKKTEAAKKEYLKALAAYRASLVSKCTCDELVNATRVRRDPWLVLQGGEGEGVYGAPGYGQFAPGFGYPPTTSAPGHPQVQSPTQMSPLAKKSPLLSSLMADPPPPMMNPPMSQPMPPSGPPMMPHGSMPPMSAASMAPQAQQGPQGALQPPTPQPHLTPLTNVPSTSPYMNQQAPGPLTSPGGGGSPGSGQQHQTQQQSPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAATQQQQQQAGQQQHQQQGGQHGQQQQPPQQPQPQQQQQQQQQQPSGQGSGGQQQGIGQPGHIGCPNSVSNCIRNGCTNLAVHNPEWEDEYCSNECVISHCRHVFSTWVASNHQQPINPTYPAPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRQ5</accession>
    <name>A0A8J5JRQ5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative histone-lysine N-methyltransferase 2D-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Kmt2d-L2</name>
        <name evidence="4" type="ORF">Hamer_G002111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRQ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="3">
        <location>
            <begin position="75"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7163052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="145" mass="16021" checksum="311933A2FB70E651" modified="2022-05-25" version="1" fragment="single">MRKGEKVDGALKVTVYEETKDVNGIEGIYEAIVATVLLNGGAASVLNSGNGIDGRPLVHVRPPRTHANRPVVITRRAKIIGYHNAGERIREIVLLMGIFKETARRWVGRYEAEGNVETRPGQPRVTTAEEDERLIQDAGRTPQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSI0</accession>
    <name>A0A8J5JSI0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G002726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSI0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="46" mass="5304" checksum="0AC568D091A8B4E0" modified="2022-05-25" version="1">MKLRAWLLTVPGRRSIEGQTTTCWTLWPTPLTLLYTSFPASPGLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSI7</accession>
    <name>A0A8J5JSI7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Clusterin-associated protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Cluap1-L2</name>
        <name evidence="8" type="ORF">Hamer_G016309</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLUAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSI7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019366">
        <property type="entry name" value="Clusterin-associated_protein-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21547">
        <property type="entry name" value="CLUSTERIN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21547:SF0">
        <property type="entry name" value="CLUSTERIN-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10234">
        <property type="entry name" value="Cluap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7161253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="222" mass="25038" checksum="7A3474424C70DE87" modified="2022-05-25" version="1">MNHRTPKCWSDVVEHLRVLCFPRMVSLENFSTPNFQLVSEILLWLMTTVDSDHDHSTAIDSQQDRYKKLGVQLNMVRLYGADKLAARELLKITNCLYEASQAAIHPRIDSEDRPEISGTSPVVSVKLASSIIMDAASLCDSLRKECDDKIKRTAALDQALDLDSMEASVVAALHALASTVTEIKEATECLVRQQEEVVEKMHKKNDSLMRNQKRLEALMKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVL8</accession>
    <name>A0A8J5JVL8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G007078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVL8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7165287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="410" mass="44623" checksum="A547EB22D7A86C26" modified="2022-05-25" version="1" fragment="single">ASKVKLFNAVSSQLLGDSVDISLREDHGEASQVNVVESRSVTDELRLLESQIKLKEAEAIARRVGIRQAEAEAKAKEFQRTFNPSLHRARQGNSNFVRDRRSWTRSPPNGASKFSTYPCSHCGKPGHRAEFCWTRLQPNTGKPAMIVTDETNTSPVGVMADLSKAESMPIGLVFTKGVVRESAVSVLASRDFDLFQESFAKDPDVGTFRPFLSQGTVEVDDVETPVTILRDSGCLQTLIKESVVAARKTDKYVVLGSLWGQGVAPLVLVRVKSSWFSGIANVAFVHELPVAGVDLILGNDLAGGQMGNVTPPPVLRERPESTIELQQLEDMPGVSPLCAVTRSMLMTKDHNATPVVDDSLSLEGLFAKPIASQDISSAVNVVTWRVASIAAQEQDDSLRLLCHSGHTTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW24</accession>
    <name>A0A8J5JW24_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Importin-13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Ipo13-L</name>
        <name evidence="11" type="ORF">Hamer_G022987</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024092">
        <property type="protein sequence ID" value="KAG7165557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW24"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040709">
        <property type="entry name" value="Importin_rep_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040520">
        <property type="entry name" value="Importin_rep_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18773">
        <property type="entry name" value="Importin_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18806">
        <property type="entry name" value="Importin_rep_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="10">
        <location>
            <begin position="96"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7165557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="942" mass="105114" checksum="0A1ADDE568BD7F62" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW77</accession>
    <name>A0A8J5JW77_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW77"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF1">
        <property type="entry name" value="TESMIN_TSO1-LIKE CXC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="847" mass="94831" checksum="E1F8EF0C69B608B2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWM4</accession>
    <name>A0A8J5JWM4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine/arginine repetitive matrix protein 2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SRRM2-L1</name>
        <name evidence="2" type="ORF">Hamer_G002851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWM4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="158" mass="16966" checksum="19C5001790197E5B" modified="2022-05-25" version="1">MVGEQSVVVVMVVNVDEKLRGSCTLADYQLQEVSVVPRNYRAPPLSVTDIFTMSAISQPQDTKRRGLLSLFNRKAKSGLHQPFLTLRHRFRRAWPRGYLGAGDYPSCVCPGLGLLTPTPCPALPCPAPQPSSSPAQPSPASSPAPAQPSPAQPRPAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JX52</accession>
    <name>A0A8J5JX52_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Longitudinals lacking protein-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lola-L4</name>
        <name evidence="8" type="ORF">Hamer_G011916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7165990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JX52"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016199">
        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008406">
        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035167">
        <property type="term" value="P:larval lymph gland hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007526">
        <property type="term" value="P:larval somatic muscle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045476">
        <property type="term" value="P:nurse cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007464">
        <property type="term" value="P:R3/R4 cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045467">
        <property type="term" value="P:R7 cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF111">
        <property type="entry name" value="LONGITUDINALS LACKING PROTEIN, ISOFORMS F_I_K_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7165990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="352" mass="38278" checksum="59F01C90279F36D1" modified="2022-05-25" version="1">MGDGMLSLYWNNHRATFCHILSTLREKERYTDATLACDGKFYPVHKLVLSTCSEYFENMFEHTPCKHPIIVLKDVKPDELEALLSYMYAGVVSVAQNDLARLIKAAEMLQIKGLAVPDEPPQSEESRRSAPSRSGREERSSPQPKRRRREENGTPSQGGSQPSSSPPSSPRASPYQADSEQSQARSRTHGESRRSDKMDTIEQPASHESQASDVKIMVDESLVKEEMVETIDNNQSEGLDTGMQYGHVGNDPGMDGSGGGEEHSHMMPNKFDQPVIPGQAQPLADAVAEALAGPSGMQGWLGGSDMTGSFSAENYGGEGSQEVHPSQAAGGAPHAQQRVSVTFNSYRKGAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZ27</accession>
    <name>A0A8J5JZ27_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADPH oxidase 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NOX4-L</name>
        <name evidence="9" type="ORF">Hamer_G014512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026055">
        <property type="protein sequence ID" value="KAG7164035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZ27"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="532"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="723"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7164035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1033" mass="115113" checksum="AE4DF827F9BB3C23" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K079</accession>
    <name>A0A8J5K079_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Ugt8-L1</name>
        <name evidence="6" type="ORF">Hamer_G019371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010027477">
        <property type="protein sequence ID" value="KAG7162654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K079"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF27">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035338489" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7162654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="515" mass="58108" checksum="B1931FF6D3FBF7B2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K088</accession>
    <name>A0A8J5K088_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Repetitive proline-rich cell wall protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PRP-L</name>
        <name evidence="1" type="ORF">Hamer_G004907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K088"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="203" mass="22918" checksum="1D4FFC14766B0814" modified="2022-05-25" version="1">MTPALSSPDPQHAVLCDLPSYTDFVYDLPSYTDLVYDLPSYTDLVYDLPSYTDLVHDLASYTDLVCAPSMTLCTDLPSYTDLVHDLPSYTDLVHDLPSYTDLVHDLPSYTDLVYDLPSYTDLVYDLPSYTDLVYDLPSYTDLVYDLPSYTDLAPTHHPPLTLAQNLLVYRSRHHQTLPTLYLTAPLPSSPPLPNLPFFSPTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0I7</accession>
    <name>A0A8J5K0I7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0I7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="72" mass="7529" checksum="9B3929692A7B1B24" modified="2022-05-25" version="1">MKALTPHNRTVYYTDGSVETTSTKAGAAFTIEGGNTSLWRTSDGCSTLQVGLAAILGALRHASINSTTMPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K126</accession>
    <name>A0A8J5K126_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor btd-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">btd-L</name>
        <name evidence="10" type="ORF">Hamer_G007267</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K126"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7165434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="83" mass="9520" checksum="0BF7DBD4F1739E88" modified="2022-05-25" version="1">MDCEPLRFSLRCRCCDKSFSNRSNLQRHLASQANYRPYSCPVCTKAFARKDVLKRHVLKHNLSQSLHAILTEPPGMVSLSPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1Q4</accession>
    <name>A0A8J5K1Q4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023277">
        <property type="protein sequence ID" value="KAG7165839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1Q4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="114" mass="13841" checksum="B4265F360B54376F" modified="2022-05-25" version="1" fragment="single">IVRLRGERLTEVNVWLVENSSKQTPHKVKHFHSAIGVQCPDCQHLCKCLYHYKCLYHYKRLPRYKRLPRYKRLPRYKRLPRYKRLPRYKRLPLVQTPPPVQTPSLNKPPEAFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1R2</accession>
    <name>A0A8J5K1R2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Ccdc56-L</name>
        <name evidence="9" type="ORF">Hamer_G018397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the COA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7167967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1R2"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="8">
        <location>
            <begin position="35"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7167967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="81" mass="9406" checksum="EBD26084D09FE794" modified="2022-05-25" version="1">MAGDSKQMPKLDLQRDSIKLSQPQLDYMRIVENQNLERVQKLARMKRNNIWVGSMLGLGVLGIYGYSIYSVKQEKFLDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2Q7</accession>
    <name>A0A8J5K2Q7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G005503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2Q7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035274332" evidence="1">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="63" mass="7103" checksum="B9D102A6647AC39E" modified="2022-05-25" version="1">MGHVFLIHLVLWCPEKVQSLSVFWNLEEEDEEEVAQMIGSLPGIDWEGNLCSSVPVPRPSPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3R6</accession>
    <name>A0A8J5K3R6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G028036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019042">
        <property type="protein sequence ID" value="KAG7168792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3R6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="158" mass="18155" checksum="FA1F35FAA10734FD" modified="2022-05-25" version="1">MFSEQFKTSEMFSEQFKTSGMFSEQSDTSAVFSEHPKTSGMFSEQFKTSEMCSEQSNTSAMFSEHLKTSRMFSEHPRLQERLVNNQTPQKCLVNTPRLQECLANTPRLQEYLVNNQTLQKCLVNTSRLQENLVKNSTLQECLANTGTIQKCLLNTQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5X1</accession>
    <name>A0A8J5K5X1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024115">
        <property type="protein sequence ID" value="KAG7165549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5X1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="334" mass="36090" checksum="3092E3BC2C6E2AE4" modified="2022-05-25" version="1">MGKISENTRFNNGLNRIRAAHEINVIKLAYLEALFQRAKLEEIRLKSLTSDSRTSEKRTHKSLSKSLQSPESGYKSLPSSILDYGLRSYSSSNISANVSNSTCGSTLLDGQALLRTIENRLQHARPQDKNSGRTLYQCGGSSSVGSLSRLTGLSPATSGTSTPARFVSPSRSDGHAVSRGSSATTPNSTPATTPGGTPKRPDGLGRPSGHVSQRSLPHSYRSRSAYSSPAVSPQRGPDPGGFLVSPSGAAPRRFSSLDLRGQLRQLPLRHTAPGFPTCVLPISPPSPAQGTQAFHRKMKLFFEIMDTQSRFSQLAQYYPYEQSHQKVGTIFSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6M4</accession>
    <name>A0A8J5K6M4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 15 member 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Slc15a2-L</name>
        <name evidence="10" type="ORF">Hamer_G020845</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019607">
        <property type="protein sequence ID" value="KAG7168678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6M4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7168678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="654" mass="74659" checksum="AEBE8C18DD84ADEB" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7J1</accession>
    <name>A0A8J5K7J1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CENPB DNA-binding domain containing protein 1-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CENPBD1-L6</name>
        <name evidence="3" type="ORF">Hamer_G011113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7J1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
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    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="99" mass="10818" checksum="E840BFAE1F9AD770" modified="2022-05-25" version="1">MPKQPATKTPSNVAKRSRVAVTLEVKLDIIKRHEHGEGTSVIGHVHGLASSTVHSIVKSANKIKELAGSATPLTATKVTRFRDAEMESMERMLSTWIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KA74</accession>
    <name>A0A8J5KA74_HOMAM</name>
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        <submittedName>
            <fullName evidence="4">Murinoglobulin-2-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Mug2-L4</name>
        <name evidence="4" type="ORF">Hamer_G011602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KA74"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF171">
        <property type="entry name" value="PREGNANCY ZONE PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="A2M"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E set domains"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="3">
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            <begin position="290"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="231"/>
            <end position="283"/>
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    </feature>
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            <begin position="231"/>
            <end position="240"/>
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    </feature>
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            <end position="271"/>
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        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7168925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="375" mass="40628" checksum="0E9103D5B04F5B91" modified="2022-05-25" version="1" fragment="single">LTSGDLPISVEHLVEPLPPPIEGTVRGVVSINVNLPPTASPKAKVLVWYTREDGEVVADTRELEVEKCLGSSASLTWSESQAQPGQQTTLTLSSDPNSVCSLGVVDRSSELLATDPDPITLEKLFNFADDFDINPWRNSQVNTHKYCHDKYLQKLTPGVSSDQGGIGFPGPSWHQSYYSDYVDALSMFDNSGLYIFTDLTVETRPCEKEERHHYFETAGLPGFAFGGASGSAGNGGGGLGGPPPSPQASFAPTTTNPSASRPPNVESSVFSNKEDSEEVADSPRTNFPETWLWDIVVLPSSGVNSQDLTLPDTITQWVGKAVCVHPEKGVALSERESITTFTPFFVDLTLPPTVKRGEILPVKMSIFNYLDRPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KDQ5</accession>
    <name>A0A8J5KDQ5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Inner centromere protein-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Incenp-L3</name>
        <name evidence="2" type="ORF">Hamer_G030167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013958">
        <property type="protein sequence ID" value="KAG7170546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KDQ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="588" mass="65873" checksum="5538E3D2A37DB45C" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJ86</accession>
    <name>A0A8J5MJ86_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOB kinase activator-like 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Mob1-L</name>
        <name evidence="3" type="ORF">Hamer_G021854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047222">
        <property type="protein sequence ID" value="KAG7153245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJ86"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7153245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="246" mass="26746" checksum="7DA11E88BED0738C" modified="2022-05-25" version="1">MSGCPDMTAPTTRQYLWFDEKGKKTRVAAPQYVDYVMTFTQKTINDESIFPTKFENDFPVSFESIVKKIHRLLFHVLAHLYHSHFREMVLLNLHAHLNCIFAHFILFNDRFRLIEDKETEILHDLVVALKLHPESEPSTSSSSSTTSTTTTTATSCSQVGGPDCSASPNTSSSNTTTTAATYSTLSLEGDCGNCSTPQEQQLSYPADITTVTNNSSSGVTPATGDAAAGGSGPPLLDTEAAPDTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJQ7</accession>
    <name>A0A8J5MJQ7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">T-complex protein 11-like protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TCP11L1-L</name>
        <name evidence="3" type="ORF">Hamer_G022337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045864">
        <property type="protein sequence ID" value="KAG7153981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJQ7"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7153981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="598" mass="66948" checksum="373FB43395DBA565" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJZ2</accession>
    <name>A0A8J5MJZ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">EH domain-containing protein 4-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Ehd4-L1</name>
        <name evidence="12" type="ORF">Hamer_G022124</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044612">
        <property type="protein sequence ID" value="KAG7154283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJZ2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051943">
        <property type="entry name" value="TRAFAC_Dynamin-like_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43681:SF1">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43681">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1067"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin-type G" evidence="11">
        <location>
            <begin position="81"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="384"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="518"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="783"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="990"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="384"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="553"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="634"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="790"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="816"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="990"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1009"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7154283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1106" mass="120565" checksum="653293DA2E9143A7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK12</accession>
    <name>A0A8J5MK12_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MICOS complex subunit mic25-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">chchd6-L</name>
        <name evidence="2" type="ORF">Hamer_G024620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045620">
        <property type="protein sequence ID" value="KAG7154072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MK12"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052632">
        <property type="entry name" value="MICOS_subunit_Mic19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21588">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21588:SF18">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="480" mass="50956" checksum="3DCD3179C5691E23" modified="2022-05-25" version="1">MGTTQSTRKITLVNDDKAGVIKLSESLAYRLRGQIEGQQTAAEVPGPAAAAEPPRAPVAPAPEPPPLITPIPHIPETPKVTYLAPVPETVAPTPIDSEPVAPEPIAQKPLIPESSILEPAAPDPVVSEPAAPESLVPEPAATGESHPLADVPVDTPSGILVDVSEPSPSVLQNVAENADLQPLALLDNVSQSQESAMIESCEPQVSLSLDESVISSEPQSPSAETLDPLVSAETVDPLVPSAQTVDPLVEETAAVTIEAIVILEQVQLSSSEMLLAAAFPVGGETPAVAEATSEATVPPSAETITVSPSLSLPIEVNEVPRKELPETASPPAAATVSPPDLEVAVKAGPPPTLSQPAGNIPPWSIYAEEAHLMVMRLREEKEQEIQKLNLNWRDKMDAREKEFTKMAHLSEEEATAALKDVEKLFLKASCSPICQNHQEAVMNCYQDHPRQSLRCAKEVENFTQCVDLSRLQSVIKQRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKA3</accession>
    <name>A0A8J5MKA3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044465">
        <property type="protein sequence ID" value="KAG7154342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKA3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21496" checksum="3453F29FD5F9E9F6" modified="2022-05-25" version="1">MLCWAHRKCKAVAVHELPDAKDKYKCLLADHGPLTSELLPDSTAYYFFWIDGIPGKYYGIFLDNLLYVELNEMTSWERAKELCARIPGHRLAMYKTTTQHDIMMELYFKNPRKGMLINARKTADGKDRVWGDKTKFSSLPKVKLMFIDAGMHRPGYTVFLSRIYGKEKSAGHDRVVCQANPRGVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKA5</accession>
    <name>A0A8J5MKA5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G019967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044137">
        <property type="protein sequence ID" value="KAG7154549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKA5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="173" mass="19651" checksum="AFD28FC1D7C759B3" modified="2022-05-25" version="1">MVNVLVLYTSHYTGQRSSLTPVLTAVQVIKRLGESRTGLGRFYQQWKTTQSLPLEPPLVQLSHLPSITSTTTITINHIRNPNLYYHSTINHVTIITALNHIIKSIECDARTTHNNGRIPNYNASAINHEASGTNHNHDEAFQTAVVDPEEEFCLQWEALQGVYMDPTFFSRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKJ9</accession>
    <name>A0A8J5MKJ9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043718">
        <property type="protein sequence ID" value="KAG7154834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKJ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035294577" evidence="1">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="90" mass="10326" checksum="FF47E793E3091CAF" modified="2022-05-25" version="1">MKMTARWVRLCVVAVSLLMYATSMTEVPSITSYKVVPKFPNELTRYCLLEEVILGAASTYLWAMECLLYCLRGQCCLVYSLFNLLQIMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKL7</accession>
    <name>A0A8J5MKL7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">yif1b-b-L</name>
        <name evidence="11" type="ORF">Hamer_G015579</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043233">
        <property type="protein sequence ID" value="KAG7154988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKL7"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7154988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="340" mass="38081" checksum="21896201E21CC2AA" modified="2022-05-25" version="1">MDYSIAGGRQPRGRRVASDNPSSTLGGGDMQENMYDQYGQPRQQQAPPQLFEDTSGQNYDYGNQGYGGMNYGYPPPGQPNQGASGGYGAYPGAIPGPQIFQDPLVANMAMQYGQSLASQGREYVDKKLEKYVSMSQVKYYFAVDTPYVMKKLRLLFFPFTHSDWSVRYEQDEPVQPRHEINAPDLYIPLMAVVTYILVAGLCLGLQERFSPDVLGMQASSALVWLVLEIFVIFATLYVTAIQTHIKSLDLLAFSSYKYVGMIVALLAGLVMQSLGYYCVLAYSSFSLVVFMFRTLRWQVQGGAAMEAYSAGNKRRLYLLLFMSGLQPLMMWWLTKHLVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKR2</accession>
    <name>A0A8J5MKR2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G patch domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Gpatch2l-L</name>
        <name evidence="2" type="ORF">Hamer_G015630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043233">
        <property type="protein sequence ID" value="KAG7155029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKR2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="558" mass="62011" checksum="5DA918B8783E67ED" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ML62</accession>
    <name>A0A8J5ML62_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041542">
        <property type="protein sequence ID" value="KAG7155464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ML62"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="119" mass="13360" checksum="B2049ED0548E5BE4" modified="2022-05-25" version="1">MIRKLTPANSTDRGEARSRVGELTKSGDNGGKLSLSHSLYPLLTPQRVPSPPRVPYTAQYPPPRVPYTAQYPPPRVPYTAQYPPPRVPYTAQYPPPRVPYTAQYPPPRVPYTAQYQDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLL3</accession>
    <name>A0A8J5MLL3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040741">
        <property type="protein sequence ID" value="KAG7155735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLL3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035250940" evidence="1">
        <location>
            <begin position="22"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="172" mass="19262" checksum="9D97AA57F693C3EF" modified="2022-05-25" version="1">MRLEMLVTTLILNWGIMAAGAKVPNKEAVASCTFSDLPGAVKHLVKEDLAAWTCNGYPNMVWDSGEVIITASCNSQHELDNKCVLARPEQKIGQCPPINSRPTNATLKYQFQHKLDLGHEQEQVYGEYYECLGDLKWKSNFGFRGRLTQCYAGKWTPVYDVCEEGKVARGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMY5</accession>
    <name>A0A8J5MMY5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MKRN1-L</name>
        <name evidence="9" type="ORF">Hamer_G005791</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMY5"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7157371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="277" mass="30341" checksum="4AB72036912B47AD" modified="2022-05-25" version="1">MAEGGGTQNVLCRYFMNNVCNKADHCRFSHDPATAQPSMFCRYYLKGTCAYGDKCRYEHSVPGYVGKVYAPPNNAEPTSTTRTDGVSSQFNVKVTQETVVPSSQPNALSASIPVGVNNVSQRLPAINHNTVMHHPTSNGISSAREMISLVAVSITQFVAMILDAHRIPHNLPSLNNKKNMSLEDARSSAKNLQNVVIKLGSALCKCLNSGSSEVLMEFGALLVNFWAEAKEPCPNLLFTCEDLAQIVMSPDGRQFLEMTLNQLQHLMSTLKSLLNYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MP98</accession>
    <name>A0A8J5MP98_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zwei Ig domain protein zig-8-like 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">zig-8-L23</name>
        <name evidence="4" type="ORF">Hamer_G024564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035215">
        <property type="protein sequence ID" value="KAG7158407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MP98"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF21">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 11, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035280150" evidence="2">
        <location>
            <begin position="27"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="53"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="138"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7158407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="288" mass="31039" checksum="B2318A9A20BCBF18" modified="2022-05-25" version="1" fragment="single">MQVWAVPRALRVALLLLLLTSSNVIAPPPTDAGEDIGASGRGGRHRRRAFPGPHFHPTSPTNVTTQLGAHAYLPCRIKNLGNKSVSWIRNRDSHILTVDRYTFISDERFTSWHEAPTQTWTLQVRYVQERDAGSYESPSVTIAGVSDLYVKSGSTVNIKCVISDALEEPTYIFWYHGERRVVSANSDRILSVDRIPPDTSIGTLTIPSVSLADSGNYTCAPASLQMASVMLHVLSGELPAAMQRGTTTSATKSSSSSSSSSSASSSSSSSGVLVVLLTTAVWLMRSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPK3</accession>
    <name>A0A8J5MPK3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TXNL1-L</name>
        <name evidence="4" type="ORF">Hamer_G011443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPK3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="167"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7158767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="339" mass="37210" checksum="0804C9D2683F3A23" modified="2022-05-25" version="1">MAGNFKVLTEDAQFQAELNQAGGKLVVADFTSARCGPCQRIAPLFEEMAARFPNGMFLKIDVNQCAAAASSQGVSATPTFIFYRNKCGGHLLNSGQITHCKTKAKEGLESFRKGLKSTRSREIFVIALMAPVLPVHRTKLDSLQGADPETLEARIRQHYGDGEGEEVEDSGVPGHIDLMPMINKAGCECLNESDDHPFTQALSSAGGYLESDTDEQLILYLSFNQAVKLHSMRIKGPAENGPKIMRLFINQPHTIDFDSAECANAVQELTLTTKDLDGELLPLKYVKLQNVMNLTIFVKNNQTDAETTHISYIQIIGSPVQTTKMSDFKRVTGKKGESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQI2</accession>
    <name>A0A8J5MQI2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031672">
        <property type="protein sequence ID" value="KAG7160073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQI2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="142" mass="15069" checksum="AE730B08C9CE5AF8" modified="2022-05-25" version="1">MFLSSFLPSSSPPRRLTNRPAEQPGSAAPGGDEPIHEGAGDQRAPHQREPPGQTCIQEAAEGTNESGGSTEERPHRLTPLPLAPSGAAAGAEDRPLQRAPFPLALPSKRRMSCYRIPCTITSRVMGVLGHLVFAPATLYLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR13</accession>
    <name>A0A8J5MR13_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U-scoloptoxin(01)-Er1a-like 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030986">
        <property type="protein sequence ID" value="KAG7160700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR13"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="290" mass="29311" checksum="0B431B32CA46B57A" modified="2022-05-25" version="1" fragment="single">MKDNETNFAKSKLRGINGNGAVNGNGYANGNGNGFVNGNGAVNGNGYYNGIVDPISALADAIGGGGVPGVDYPILASVPFTGFSCGGLIPGYYADTAPEAGCQLSAESYAAPEAGCQLSLMLPLRPAVNRVFLQFLSLVFHICQADGRSDSFLCPNGTIFNQQYFVCDWWYNFDCSTASQFYDLNALIGVVNGNGNGYTYGVNGVNGASNGNGNGYTNGNGNGLTNGNGNGLTNGNGNGNGYTNGKGNGNGLTNGNGNGLTNGNGYTNGNGNGLANGNGYTNGNGNGLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRT2</accession>
    <name>A0A8J5MRT2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylneuraminate 9-O-acetyltransferase-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Casd1-L2</name>
        <name evidence="2" type="ORF">Hamer_G023574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030192">
        <property type="protein sequence ID" value="KAG7161062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRT2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="524" mass="60165" checksum="380EA0F75AA74C21" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSG5</accession>
    <name>A0A8J5MSG5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Tigger transposable element-derived protein 1-like 266</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TIGD1-L266</name>
        <name evidence="2" type="ORF">Hamer_G007535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSG5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="123" mass="13593" checksum="493FC635FBB99E96" modified="2022-05-25" version="1">MALKRPHPPSSCCGKVPKQAKREKKVMTPVKKLQLLDKLKGVQSFAACGQDYGINGICLLHQEEKDIHNAVALNDPSSAKVAANVRDTAMVKMEKALNIWIEDFNCHHTPLSQKFICESQGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTG1</accession>
    <name>A0A8J5MTG1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase TRIM37-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Trim37-L</name>
        <name evidence="12" type="ORF">Hamer_G019366</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027477">
        <property type="protein sequence ID" value="KAG7162649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTG1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070842">
        <property type="term" value="P:aggresome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19779">
        <property type="entry name" value="Bbox2_TRIM37_C-VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03773">
        <property type="entry name" value="MATH_TRIM37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16619">
        <property type="entry name" value="mRING-HC-C4C4_TRIM37_C-VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037299">
        <property type="entry name" value="TRIM37_MATH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053003">
        <property type="entry name" value="TRIM_RBCC_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36754">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36754:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="51"/>
            <end position="91"/>
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        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="11">
        <location>
            <begin position="293"/>
            <end position="420"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="464"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="855"/>
            <end position="915"/>
        </location>
    </feature>
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        <location>
            <begin position="961"/>
            <end position="989"/>
        </location>
    </feature>
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        <location>
            <begin position="157"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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            <end position="989"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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            <dbReference type="EMBL" id="KAG7165500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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            <taxon>Nephropidae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
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                <person name="Kohn A.B."/>
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                <person name="Greenwood S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7165980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="119" mass="12458" checksum="B437C2062F4E0461" modified="2022-05-25" version="1">MAFKGMLVFLLLAGVITLVASENTKSQNKKRGEEGRFLFTTDENQSITIGTASLTTLALLGVVAVLAAAAAIILLPQDDASSGYASATSAYGATAIHRSLDDAAAKYEQTDTPVDRHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5MVZ8_HOMAM</name>
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        <submittedName>
            <fullName evidence="12">Neural-cadherin 2-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="12" type="ORF">Hamer_G023658</name>
    </gene>
    <organism evidence="12 13">
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        <lineage>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023849">
        <property type="protein sequence ID" value="KAG7165711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:establishment of planar polarity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="58"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="465"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="9">
        <location>
            <begin position="519"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="740"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="9">
        <location>
            <begin position="781"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7165711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="997" mass="105404" checksum="CACD6CBD85367640" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW82</accession>
    <name>A0A8J5MW82_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative winged helix-turn-helix domain containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G013198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024020">
        <property type="protein sequence ID" value="KAG7165682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW82"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="2">
        <location>
            <begin position="39"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7165682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="115" mass="13394" checksum="B7B09DFA761F0C77" modified="2022-05-25" version="1">MSWSYSNRSVILPTTTMGHQHHAISQRRQFVGIRNAELSISEMARQIGVSRSTMQYWLQQFEESGNLTNFPRSRRPRLTSAADNTRIVAEIRGLPFTNTRWPRRSGCIWRSRLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW96</accession>
    <name>A0A8J5MW96_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G010982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW96"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="77" mass="8849" checksum="08C050813CD6E250" modified="2022-05-25" version="1">MLEVTGIPNHTDYPVPYSALVDGTLGTRTSKYDCHYRGQPGDPHITINLRQEDYHPHCRHCFHQSPCAELQELRDIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWP5</accession>
    <name>A0A8J5MWP5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SUMO-conjugating enzyme UBC9-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ube2ib-L</name>
        <name evidence="11" type="ORF">Hamer_G020876</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023275">
        <property type="protein sequence ID" value="KAG7165844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWP5"/>
    <dbReference type="SMR" id="A0A8J5MWP5"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000013">
        <property type="entry name" value="SUMO-conjugating enzyme UBC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7165844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="160" mass="18322" checksum="D7A6658658270DB1" modified="2022-05-25" version="1">MSGIAIARLAEERKAWRKDHPFGFIARPTKNPDGTLNLMNWECAIPGKKGTPWESGLYRLRMIFKDDYPSTPPKCKFEPPLFHPNVYPSGTVCLSLLDEEKDWRPAITIKQILLGIQDLLNDPNIKDPAQAEAYTIYCQNRLEYEKRVRAQAKAMSAPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWS0</accession>
    <name>A0A8J5MWS0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger BED domain-containing protein 4-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Zbed4-L5</name>
        <name evidence="2" type="ORF">Hamer_G010404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWS0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47611:SF1">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47611">
        <property type="entry name" value="HAT DIMERISATION DOMAIN, C-TERMINAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="103" mass="11906" checksum="E27CEBD71ED9792E" modified="2022-05-25" version="1">MKRNKFFTLANRSSTQRPTTSETVVSLYLNQPCLQEDGDHLGYWKAKQFPVLTRLAPKYLAIPATSAPVERLFSIAGKLFRPERCNLSNKRFEQLMMIRCNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXD8</accession>
    <name>A0A8J5MXD8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitotic spindle assembly checkpoint protein MAD2A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mitotic arrest deficient 2-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Mad2L1-L</name>
        <name evidence="10" type="ORF">Hamer_G010543</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXD8"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990728">
        <property type="term" value="C:mitotic spindle assembly checkpoint MAD1-MAD2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000002">
        <property type="entry name" value="Mitotic spindle assembly checkpoint protein MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="9">
        <location>
            <begin position="16"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7166867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="209" mass="23834" checksum="31B4D5B011C88C3F" modified="2022-05-25" version="1">MEAVKQETCNNSITLKGSAQLVSEFFYYGINSILYQRGIYPPESFTLKQQYGLTLYTTTDKGVKDYLNNVLAQIKDWLEAGNVQRLVLVVTNVDTKEVLERWDFDIQHDPSYGPQSIKEGKVTGKDLKVIQKEMRDVIRQITACVTFLPLLDCVCAFDLLVYTHKNAEVPEKWSESAPCFISNSQEVRLKSFSTSIHKVEACVSYKIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY02</accession>
    <name>A0A8J5MY02_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G010138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY02"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7167751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="142" mass="15269" checksum="8AE62EC27844EA76" modified="2022-05-25" version="1">MSETKEEALCNNAQNHRQQLLNHQQELERDLEAGSCADEEDEGEENTDEGGEGEEGEEGEEGEKLSGTPKQVIPPLYNVEPGCTSLGCYSAIATFIVMIIGIVALLMYSSPADATADNLVIEEELELTTLPSVSAQPDAPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZ55</accession>
    <name>A0A8J5MZ55_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative articulin p60-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018882">
        <property type="protein sequence ID" value="KAG7168816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZ55"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035293262" evidence="1">
        <location>
            <begin position="17"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="161" mass="17154" checksum="B6F9A870D67BFA19" modified="2022-05-25" version="1">MRSIVLLPFVLASVMGSTTLIHAPAAVAYSNLNLNIPAPVPAGDAPAPELLVQRTPVKALGRPVVSYTPQITEVRPELKIIEKTYDVAVPKPVYKTKEVTPIHHQYVPEPYAVPQPYAVPQPYAVPAPYAHPVPIQHHVAAVPAVYSVGAVAPAAVAYVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZS5</accession>
    <name>A0A8J5MZS5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">4'-phosphopantetheinyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Nrx4-L2</name>
        <name evidence="23" type="ORF">Hamer_G012255</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>apo-[ACP] + CoA = holo-[ACP] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:12069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>apo-[ACP] + acetyl-CoA = acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46565"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neurexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000003">
        <property type="entry name" value="L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003585">
        <property type="entry name" value="Neurexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF91">
        <property type="entry name" value="NEUREXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00294">
        <property type="entry name" value="4.1m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0965">Cell junction</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 18" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1435"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="20">
        <location>
            <begin position="257"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="20">
        <location>
            <begin position="361"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="21">
        <location>
            <begin position="474"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="21">
        <location>
            <begin position="664"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="819"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="21">
        <location>
            <begin position="1073"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1240"/>
            <end position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG7170033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1501" mass="169481" checksum="1A669F0573DC282C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZV6</accession>
    <name>A0A8J5MZV6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014835">
        <property type="protein sequence ID" value="KAG7170225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZV6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="96" mass="10026" checksum="9E2218C476346743" modified="2022-05-25" version="1">MERKLKKNNPTTLTSSATQVASDGATMAGASVGAGVETLLVNSGEVGEGETLQDFSISDKTSLLSCKVSVDAVGGRRWLGDGSFWCSKQLSVTRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N133</accession>
    <name>A0A8J5N133_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SET and MYND domain-containing protein 4-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Smyd4-L5</name>
        <name evidence="14" type="ORF">Hamer_G013889</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl-[protein] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51736"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012946">
        <property type="protein sequence ID" value="KAG7171094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N133"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10536">
        <property type="entry name" value="SET_SMYD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044421">
        <property type="entry name" value="SMYD4_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="13">
        <location>
            <begin position="299"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7171094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="538" mass="59562" checksum="B4D45C743BF92A35" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1L1</accession>
    <name>A0A8J5N1L1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DnaJ subfamily C member 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Dnajc9-L</name>
        <name evidence="5" type="ORF">Hamer_G014701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1L1"/>
    <dbReference type="OrthoDB" id="110024at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000035">
        <property type="entry name" value="DnaJ homolog subfamily C member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="16"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7171566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="259" mass="29857" checksum="B337505A0DF418D7" modified="2022-05-25" version="1">MTGLLDSCEELFASQDLYKVLGVESNASDNELKKAYHRVSLKVHPDRVDKDEKQEATQKFQTLGKVYSILCDKDRRAVYDESGEVDDENIAPDDRDWDQYWRLLFKKITVEDIKNFEAEYKESDEELNDLKQAYIEGEGDMEYILQYVLCCTIDDEARFTKIIHRWIKKKEVPNFSNFSNETKRKKETRKRKAAAEAEEAEEMKKELGLGDTTDSLKALILKRGKQREAEMDCFLDSLATKYGGGGSSKKKSSKKGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1X5</accession>
    <name>A0A8J5N1X5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 26-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Zfp26-L12</name>
        <name evidence="14" type="ORF">Hamer_G023934</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011789">
        <property type="protein sequence ID" value="KAG7171727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1X5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000870">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029309">
        <property type="entry name" value="CaRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15299">
        <property type="entry name" value="ALS2CR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="575"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="604"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="689"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="314"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7171727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="827" mass="94615" checksum="7BBBF0489C66E7ED" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N230</accession>
    <name>A0A8J5N230_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Divergent protein kinase domain 2A-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Dipk2a-L1</name>
        <name evidence="8" type="ORF">Hamer_G000682</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIPK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N230"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020519">
        <property type="entry name" value="DIPK2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022049">
        <property type="entry name" value="FAM69_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32073:SF10">
        <property type="entry name" value="FAM69 PROTEIN-KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32073">
        <property type="entry name" value="GH11358P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12260">
        <property type="entry name" value="PIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035153902" evidence="6">
        <location>
            <begin position="31"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="FAM69 protein-kinase" evidence="7">
        <location>
            <begin position="247"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7171771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="510" mass="56377" checksum="A684EEB2B85D41C1" modified="2022-05-25" version="1">MQLLRIHYQKLFVCVSFVMLVLVVVRVWEGDDGTVATHQNLPGSLKIPEKRVSGVRENSINIDSPVLSASQHSGRGATKKKKKAAGTNTYTDLFQDMAKEEMCPLCFGHDLCEDVSAGFLTLASDTPSKQDGAAMYEAYLGDMHKLSVKVPLGDRFSRLDEAVCMNASLGTGCSVGSAAYRSFLARPQPLTTQVLHHLLRVVGIPRTQYPLLMCPSEKLLTVIERSFDDNDDHNLSQGERITLFTTLAIAPDIVVLKLLTKASLNVGFPRLVGVCGRLGVLEDEMTPLAFLLGEPFNVRASLAAQILTMVDDFMEDDPDWYLFYGSWSLEKLAVNKEGEVVLTDLASMAVVDKSLFRGDYEDGSENRVQEVCNKECFQKFTGEVYREGHDTEEICSRVEDVGHLMYAAVCAMILSDMEQHKYVDYFTSSAGLLHNIPAADRATVEELLAECVDEAAPGGRLQSAQELRDFLSDFLLDEDEEDGDDAAGNKDDDDGEDYDDDDYDYGEDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N284</accession>
    <name>A0A8J5N284_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative UDP-glucuronosyltransferase 1-8-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ugt1a8-L2</name>
        <name evidence="2" type="ORF">Hamer_G000931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N284"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035287543" evidence="1">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="94" mass="10357" checksum="9E36148753E6C04D" modified="2022-05-25" version="1">MRPILLLVVVVMLLGGAVSELPPPERSYNILMVLMVASPSHRNVFVSLAEGLADRGHKVHMLSCLSNFSTARNITQHYVGLNIMDDLPFNVQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N309</accession>
    <name>A0A8J5N309_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sodium-dependent neutral amino acid transporter B(0)AT3-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Slc6a18-L1</name>
        <name evidence="11" type="ORF">Hamer_G009624</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N309"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002438">
        <property type="entry name" value="Neutral_aa_SLC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF236">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01206">
        <property type="entry name" value="ORPHTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7172268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="611" mass="68998" checksum="A3A3E879034A1CEB" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N682</accession>
    <name>A0A8J5N682_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Activating transcription factor 7-interacting protein 1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ATF7IP-L1</name>
        <name evidence="2" type="ORF">Hamer_G003290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N682"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="307" mass="30684" checksum="A8908061CE5883B2" modified="2022-05-25" version="1">MWWSTVMVVMEHSDGVVMGSGVVVMGSDVVWWGIVVEQCGGVVMWMVVCSCGGEIVMESVVVSDGVVMDSDGSDGSGGVVVDSGDDGVGGGDGSDSGGRSVVGSGGWESGGMMEHGWWGIVVDSGVVMEVTGGCVTGDCVTVTVVVIGDRVTGECVTGDCLTSDCLTGDCVTGDCLTGDCVTGDCVTGDLTGDCVTSDCLTGDCVTGDCVTGDRDITGDCLTSDCLTGDCVTGDCVTVTVVVTGDCVTGDCVTGNLTGDCLVTGECVTVTMYLVTVVVTVTVVVTGDCVTGDCDSNSVVYRSISGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7B4</accession>
    <name>A0A8J5N7B4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">IWS1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Iws1-L</name>
        <name evidence="12" type="ORF">Hamer_G015235</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IWS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7175025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7B4"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000001">
        <property type="entry name" value="IWS1, SUPT6H interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="11">
        <location>
            <begin position="632"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="318"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7175025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="825" mass="90622" checksum="232752B634C5589E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7D7</accession>
    <name>A0A8J5N7D7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-alpha-acetyltransferase 30-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Naa30-L</name>
        <name evidence="4" type="ORF">Hamer_G016387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7D7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7174493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="293" mass="31977" checksum="A07F8CA18525A212" modified="2022-05-25" version="1">MSETHLRRVLVEDIPSLVACHTVASQSADLAPVHSARVRSSHAHVMEKRTVADGTTHVIDKRPLTDGVAHSSGLATELREKLTIKIGVMNGMKIGTTDAEVHVPSVKSTKSLVLEEQCSESSHDSASKSDINGTVCNGHSVSEATSSNSIAISDTFSINSEKSSDSSHSFSGARPRTRNTSNSSQSTQPKSENDLSSTSESLITPEICISPVPLIVDNDLKVDYVNYENELQMSAIMRLIQKDLSEPYSIYTYRYFIHNWPKLCFLVRSIIVCVGVCQCQGVELCLKVKLRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7J0</accession>
    <name>A0A8J5N7J0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007950">
        <property type="protein sequence ID" value="KAG7174068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7J0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24409" checksum="9D88AC4D565992E2" modified="2022-05-25" version="1">MGPKFKGPGVLHGPCLQWLSAVNQPILHKKTYEQLNRSCNICSFHFSPKNYINGTPHSRLTKLACPDQNLTDNARDSSSIAANCSYESAFDGSTQGSGNIEKEISVDYTTDVRPRDLQYDFDDLDLASTVEFDVILTRESWDPAFPDPALSGKEVVTRQSELGKKQLNMAILLGPYHHHHLSHQAKVKLTELSHCALLSLLQLFQLMNGLLGIQNVVGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA03</accession>
    <name>A0A8J5NA03_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ran-binding protein 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Ranbp9-L</name>
        <name evidence="5" type="ORF">Hamer_G015510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RANBP9/10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA03"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="174"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7176690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="542" mass="58954" checksum="3AB4964C53954D4E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAV4</accession>
    <name>A0A8J5NAV4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G030047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004375">
        <property type="protein sequence ID" value="KAG7176089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAV4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="445" mass="48857" checksum="129CDD668A497C69" modified="2022-05-25" version="1">MPGCGGQQPHVTYTIPVVWWPTYYLHNTSSVTAKHVTHNTSSVAANNHMLPTHHRVAANMLPPQYQYVAANNHVLPPQCQQCGGQQPRVTHNNSSVAANNHCDGQQPRVTSTIPVVLRPTTTCYLHNTSSVAANNHVLPTIPVVWRPTTTCYLHNTSSGGQQPRVTSTMPAVWRPTTTCYLHTTSSVAANNNMLPLQHQQWWLTCYPQYQQCGGQHVTSIIPAVRRPTTTCYLHIQAVAANNHVLPPQCQNVGPTTTCYPQCQEYGGQQPRVTSTITVVWRPTCYLHNTSSVAANNHISVAANILPPQYSSVTANMLPIIPAVAANNHVLPTMPVVWRPTTTCYLHNTSSVAANNHVLPPQYQCGGQQPRVTHNTSSVAANNHVTSTIPAVWRPTTTCYLHNTSSVRPTTTCYLHNTSSVAPTPTCYPTIPAVWRPTTTCYPQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCH9</accession>
    <name>A0A8J5NCH9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002237">
        <property type="protein sequence ID" value="KAG7177475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCH9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="147" mass="15386" checksum="FD66C619CC43ECD5" modified="2022-05-25" version="1">MLVVEERVDTGYGDVKLCNVLFEGRIGVVSGSDGGRASGYSATEMGAKGGASGVGYVPRRKSKEGDDEVLCIYLGGYEERKRHVDDGAGNNRGGCSIPRDSVFVAVVPVTGAEKKASCERIAVVPLTGVYGAEKMVSSECIGVCDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDK4</accession>
    <name>A0A8J5NDK4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Obscurin-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">OBSCN-L6</name>
        <name evidence="9" type="ORF">Hamer_G023785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001720">
        <property type="protein sequence ID" value="KAG7177807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDK4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF14">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE DAPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="48"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="143"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="285"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7177807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="599" mass="68177" checksum="775B08A424E221C4" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T105</accession>
    <name>A0A8J5T105_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011989">
        <property type="protein sequence ID" value="KAG7171675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T105"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035174565" evidence="1">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="136" mass="12003" checksum="66767223BED64B0E" modified="2022-05-25" version="1">MKFLLPLVGVALLASVSHADGHGGSGRHGGGGHGSGGHGGGGYGIGGYGGGGYGGGGGYGGISGTSNNNFNHAGRLGGGHGGFGIGGSIGGYGGGGHGGYGSGGSYGGGGYGGSVGGYGVGGGFGGGGHRGGKYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T227</accession>
    <name>A0A8J5T227_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Elovl4-L</name>
        <name evidence="12" type="ORF">Hamer_G000816</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T227"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF12">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="273"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7171886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="323" mass="36969" checksum="7C5E68B09FF4D47E" modified="2022-05-25" version="1">MEVLQEKFHNIQDFYKWSLSISDDRVKDWPLMSSPLPTLGFMTAYLTMVKIGPKIMASRPALQLRIPLIIYNLAVMLLNLYIGVELAVVSVRLQYSWFCQPVDYSTNPDEMRIAAALWWYYFSKLVEFTDTLFFILRKKTNQLTFLHIYHHSTMFCLWWIGIKWVAGGSSFLAAMMNSFVHVIMYAYYGLSAFGPSLQKYLWWKKHITCIQLIQFASAGVLGARAIVVGCDFPLWMQYALVQKKLKNSRNGTVRHHGETNGVVANGVASKRFNANGISSQDGQVDKNTSGKKTDKINGEPKSQHSNVRTRAQARREGRSRQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T3A6</accession>
    <name>A0A8J5T3A6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kelch-like protein diablo</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Klhl18-L</name>
        <name evidence="7" type="ORF">Hamer_G001146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T3A6"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18247">
        <property type="entry name" value="BTB_POZ_KLHL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030603">
        <property type="entry name" value="KLHL18_BTB/POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF17">
        <property type="entry name" value="KELCH-LIKE PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="47"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7172141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="581" mass="64928" checksum="0AD9C50A0E26DCE2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T822</accession>
    <name>A0A8J5T822_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Casein kinase 1-like protein 4-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ckl4-L1</name>
        <name evidence="2" type="ORF">Hamer_G008608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T822"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="80"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="251" mass="27868" checksum="0E288280E571C88B" modified="2022-05-25" version="1">MTQFVFYLNAAQELVKPGIKRKATSSFLSSLNPKRMKLEEDTKNLKSSVVPVTTTVSSSTSSSSPVPTTSDIPKISWDNLHYQKINGGGLHGTTDHYNFTRDNGDTTEVIVKKLRNGNALPLEARILHELAGAGGAPLLFGVTTDPHALVMEFCPGITFTEALKQLDKKTCQQAYSSIVTAVQEFHKAGFNHLDLHDDNVLIDTSTVPFKCHIIDFGETQKLSDDDFFDRIARECDLSFLQRIKETIELTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TCU7</accession>
    <name>A0A8J5TCU7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Neuroblastoma suppressor of tumorigenicity 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nbl1-L</name>
        <name evidence="7" type="ORF">Hamer_G000956</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TCU7"/>
    <dbReference type="OrthoDB" id="8196271at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038098">
        <property type="term" value="P:sequestering of BMP from receptor via BMP binding"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
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        <location>
            <begin position="47"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7171992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="247" mass="28441" checksum="80CADA9D614D66FC" modified="2022-05-25" version="1">MWSSWTWLLTMFVVVVVATNDVFPPPPDPAETDSTITQQHRDSSDHHTVHNLVLNPEQHSLCELKHIRQIVTHAHCTSKEMENYVCVGTCFSYTVPQTEPETPGDEQLDYCDSCQASESHWTTIQLDCEEYGNAYQVTKNIQMITNCSCSPCHPTRSQPTIDNNEVTYAPNDHHHVNELIFKMLPDGHKFKEGLQTVQRPDTNRELQYTEMSIDNLKKRLYNDPHPEQLLRGKVIYKHSASFTDNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TGY4</accession>
    <name>A0A8J5TGY4_HOMAM</name>
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        <submittedName>
            <fullName evidence="3">Serum response factor-binding protein 1-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">srfbp1-L</name>
        <name evidence="3" type="ORF">Hamer_G015284</name>
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    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7175064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
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        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="216"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="759"/>
        </location>
    </feature>
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        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
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            <end position="240"/>
        </location>
    </feature>
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            <end position="269"/>
        </location>
    </feature>
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            <end position="283"/>
        </location>
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            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
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            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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            <end position="378"/>
        </location>
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    </feature>
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        <location>
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            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
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        <location>
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            <end position="576"/>
        </location>
    </feature>
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            <end position="634"/>
        </location>
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        </location>
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            <end position="716"/>
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    </feature>
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        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7175064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="788" mass="87495" checksum="B960115C255CEF0F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIF5</accession>
    <name>A0A8J5TIF5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinesin-like protein KIN-7G-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">KIN7G-L</name>
        <name evidence="6" type="ORF">Hamer_G015230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7175020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIF5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="728"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="893"/>
            <end position="951"/>
        </location>
    </feature>
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        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="918"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7175020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="951" mass="110149" checksum="D4F8BA1B3BF025AF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJT6</accession>
    <name>A0A8J5TJT6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin-like 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Clec-L21</name>
        <name evidence="4" type="ORF">Hamer_G032118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJT6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21407:SF5">
        <property type="entry name" value="HL04814P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21407">
        <property type="entry name" value="RE43931P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035194926" evidence="2">
        <location>
            <begin position="16"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="60"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7173478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="196" mass="22332" checksum="DF0AE5485251DEB6" modified="2022-05-25" version="1">MKTIILFVLTTAVWAEELYVKNEGTPVIFGVGSDGDHIMTILPQNRFCDHARRPIVDEVFQGRAYHFSWCHNGGRSYTWYDASHHCQRLGNGFQAVSIEHPNEDNFVAGVLRTYQMRDIWTSGTKLGSYQWYWETGVSTGYTNWSNTGRLGRSQPDNADGNEQCLAVVNSLGVGWHDSRCNTLRPVICETEAFYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKN6</accession>
    <name>A0A8J5TKN6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pogo transposable element-like 50</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Pogo transposable element-like 51</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Pogo transposable element-like 52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Pogo-L51</name>
        <name evidence="5" type="synonym">Pogo-L50</name>
        <name evidence="6" type="synonym">Pogo-L52</name>
        <name evidence="5" type="ORF">Hamer_G005728</name>
        <name evidence="7" type="ORF">Hamer_G008207</name>
        <name evidence="6" type="ORF">Hamer_G026927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010032274">
        <property type="protein sequence ID" value="KAG7159769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKN6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018586">
        <property type="entry name" value="Brinker_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09607">
        <property type="entry name" value="BrkDBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="TrpR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brinker DNA-binding" evidence="4">
        <location>
            <begin position="13"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="74"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7157318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7159769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7177569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="195" mass="22838" checksum="C17A39C8091784AE" modified="2022-05-25" version="1" fragment="single">LPQNLTMAPIVKRRRYEACFKLKVIAYAQSHNNCAASREYGVTEKMVRDWRSKEHLLRSMPRNKCAMRRGTAHWPILEKHAVDMVHEQRQNGYIVSRNMIRMWALKWAKQNQEHSKDFKATTSWFIKSFKKCGISNSMDGMEDDMLWEDEDETEAEATSSDLEFDPYDEAAINVSQDVLEELMMSDVDDVDFEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TMQ4</accession>
    <name>A0A8J5TMQ4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HORMA domain-containing protein 2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">HORMAD2-L1</name>
        <name evidence="7" type="ORF">Hamer_G008292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TMQ4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7177645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="133" mass="15411" checksum="70AD3EFEEF44773A" modified="2022-05-25" version="1" fragment="single">SSYDDRNLDGLQLKMLLEKSASLSSNMVVSWLKGCFEAIEKQYLRQLTFIIYADPDNPELALETYTFKFQYTMEAGPIISELEANSEMCKKERKFAVKKSTEKMLRTILLLTQTLKPLPRKVHLAMKLGYYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TNV3</accession>
    <name>A0A8J5TNV3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Collagen alpha-1(IV) chain-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Col4a1-L2</name>
        <name evidence="2" type="ORF">Hamer_G027733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003657">
        <property type="protein sequence ID" value="KAG7176208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TNV3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0176">Collagen</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="234" mass="24905" checksum="E2E6D10D7B25597A" modified="2022-05-25" version="1">MLVREIMTPAPLHRGLPALPGSAWSTGVHLVYWGLPGLLGSAWSTGSTWSTGVCLVYRGLPVYRGLPGLLGSTWSTVYLVYWGLPGLPGSAWSTGVCLVYRGLPGLPGLLPALVYWGLPGLLGSAWSTGVCLVYRGLPGLPGSAWSAWSGLVYWGLPGLTGSAWSTGVCLVYRAAWSAWSAWSTGVCLVYRGSTWSTVRLVCLVYWGSPGLPGSTWSTGVYLVYRLFPSLSTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J3D2</accession>
    <name>A0A8J5J3D2_HOMAM</name>
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        <submittedName>
            <fullName evidence="5">WW domain-binding protein 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Wbp11-L</name>
        <name evidence="5" type="ORF">Hamer_G009407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J3D2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13361">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13361:SF1">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7153737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="631" mass="69331" checksum="5C7C4EEE688CCDE6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J6Z5</accession>
    <name>A0A8J5J6Z5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046512">
        <property type="protein sequence ID" value="KAG7153571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J6Z5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="163" mass="18245" checksum="2ECA5F449DF57C35" modified="2022-05-25" version="1" fragment="single">KEKEREKTQEQQNKTYSAVTKLTRETTKILEKVATPPPANQPIVLQLGNNLSVKIMTSIIHAHIMNIARPGTFAKAARDMFAANNLPDMEFPNDVPSSEIFNFIYKSESTEIQIPTTHEPSTHEPSTQEQTTSDIQPEPASEEESMEDSSEDETTTITEQAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J9N9</accession>
    <name>A0A8J5J9N9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046424">
        <property type="protein sequence ID" value="KAG7153588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J9N9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="50" mass="5225" checksum="A255BA8A06780C82" modified="2022-05-25" version="1">MPVNDQAEAGPPDDIPTTTSAVDHYLPKSSTTNSPGSESLFSPFSTASDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J9S1</accession>
    <name>A0A8J5J9S1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G patch domain and ankyrin repeat-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Gpan1-L</name>
        <name evidence="3" type="ORF">Hamer_G009264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J9S1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039146">
        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="267"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7153618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="373" mass="42592" checksum="F24303A18E2FD489" modified="2022-05-25" version="1">MDNTDHLHPNWKALATAHMKWKVFVQAQPEIPLEQKEKQKKIYMSLDGEDAKKFYEELVEDCSHPSSSVDHKQLEIGNSERAPNLDKDDCDEVEENSNQKWYSGKKECPQSIHKAMKFAQNNDSVNLREMVTNGFNVNAKDEYGWSLLMVSACAGAKDAVQLLLEHKARTGARDSKGNTAIYLATMKGHRKIVDMLINCSKKKDSNYQSPEDVNVVHLKKKSLTEEFFCDICQKTIKESTKIQHETSIVHQFKLGMGANKTMYGIPPSNKGYQLLVNQGWDTEKGLGPQSSGTKFPVKTVLKRDREGLGNVKKDIARVTHFGPADTDAVERVCKPGERVERHNTLSRRERKKQKTEDQRKEIEIRRMLNEPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCR2</accession>
    <name>A0A8J5JCR2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Splicing factor 3B subunit 1-like 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Splicing factor 3B subunit 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Sf3b1-L1</name>
        <name evidence="3" type="synonym">Sf3b1-L2</name>
        <name evidence="2" type="ORF">Hamer_G026937</name>
        <name evidence="3" type="ORF">Hamer_G027101</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041156">
        <property type="protein sequence ID" value="KAG7155565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010012274">
        <property type="protein sequence ID" value="KAG7171395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCR2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7171395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="169" mass="18749" checksum="D6699F692116E1ED" modified="2022-05-25" version="1">MNTEFRNLTSKTVLLKSLSFLFEYIGEMGKDYIYAVTSLLEDALMDRDLVHRQTACAAIKHMAIGVYGFGCESAMVHLLNYVWPNIFETSPHLVQAFMDSIEGLIVALGPQKEAEEDLQKLGGGDVEMKETLERKIWLSKRSARSEGDEPPAESVNDPAVRVAGTLPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHR4</accession>
    <name>A0A8J5JHR4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helix-loop-helix protein 13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hlh-13-L</name>
        <name evidence="7" type="ORF">Hamer_G005993</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHR4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11416">
        <property type="entry name" value="bHLH_TS_ceHLH13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000035">
        <property type="entry name" value="Pancreas-specific transcription factor 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF97">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="220"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7156273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="341" mass="37538" checksum="AA9C8190D84C7C8A" modified="2022-05-25" version="1">MSASGWCLGGRGQVGLSAGGGIREMKSREPICLLSGPLGTTIRTRSLIGGQADPPAPSASAPVGREIDSPVYITAIKSTVNSRRAGDPVAESEFQFLARERQSFLTEDKKWRLRGSMAEALVGSVAPVPRQVGCGQVAPPSQVTPPYAEFFTSLPQSHTPPGQYSHVYTHHPQQQQQQQQQHQQQQGRGDLGSNSPPNNVGTCDDGEDEYYTTGSPYRVQRHAANIRERKRMLSSINSAFEELRTHVPTFPYEKRLSKIDTLRLAIAYIALLRELLTSDLDPVTHIEKGLRGELSSDQCHMWNTSDLTARLSWINWENLGVSPSRRSIFSSISLTSESLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JI74</accession>
    <name>A0A8J5JI74_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Pao retrotransposon peptidase-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G014924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035946">
        <property type="protein sequence ID" value="KAG7158040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JI74"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF9">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="430" mass="47718" checksum="4D6129C18E951D24" modified="2022-05-25" version="1" fragment="single">KPWREKVNWDTLLDDIYIQQWEKIRDKFRLSTKINVPRRFDIGKDMVDYDKDQLHVFYDASAKAYRAVIYYVAGTGCSLIMAKTKVAPLTPIQLADKIIDAPHVTSSILDGPAVVEMLKPGGSKTFQEYSAAVFIPYIESQLEYRSRLDLVWDCYLKSGSLKATVRCNHGKAFEDASLPLVLYLATGKTFSSTVTTKRNSSVSCQNRLCKSKQLVVTDKKQVLTVPPRKDTANLAPCNHEEADTRMMVHAADALKCGHRRILIRTVDTDVVILAVALANERRKNRRCIAAPQIAKALGPEKSRALPVFHAITGCDTVSVFAGHSKKAAWAKWNAFPEVTTAFLSLASTPSELPDGVLSTLARFIVLLYDRMSTCCDVNVLRKKLFSRKSKSLEHLPPVSSSGAAHKESCLSGWTYLGTGRNSVCQSAIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIX8</accession>
    <name>A0A8J5JIX8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ceramide synthase 6-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CERS6-L3</name>
        <name evidence="11" type="ORF">Hamer_G021248</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
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        <text evidence="3">Sphingolipid metabolism.</text>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
    <sequence length="373" mass="43777" checksum="5A7C91F05B0C4289" modified="2022-05-25" version="1">MTQYFTNNTMMGEYIRQVSDAFWRPDFWLPFGLRWEDLQSTGDLQLAEFSDVWTYPLLFSIIFVLIQHLILEPLVLSPLARAAGISNWRPPPPPPNTALEVVFLQHGSIAPEAVLMKASRTSNLSVRQAERWLRARHKATRINKHDMFVNNGVTAIMHSAFCISGWILMYNKPWVWNITLCWQNYPYHNLDVEVWWYYMVILASFWAVTISEIVQPRRKVDGRYKIIFHHLCTVMLLTFSWICHFTRIGTVVLLVHECADIPLLIAKMFKYSGWEKVSNVLFAVFLVLWLVTRCGIYPFWVMPRVFFESTTYMMMPSAYLFFTLLTALLIVNQLWTVLILRVLFKALLQKTPLKEERSTTESEDKDEDTKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JK86</accession>
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    </gene>
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            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
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                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
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                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037402">
        <property type="protein sequence ID" value="KAG7157559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKK0"/>
    <dbReference type="OrthoDB" id="10035013at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026828">
        <property type="entry name" value="SAPC2_1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057953">
        <property type="entry name" value="SAPC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14907">
        <property type="entry name" value="FI14130P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14907:SF2">
        <property type="entry name" value="SUPPRESSOR APC DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25825">
        <property type="entry name" value="SAPC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11414">
        <property type="entry name" value="Suppressor_APC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor APC" evidence="2">
        <location>
            <begin position="15"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7157559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="604" mass="67683" checksum="809C256EF8285714" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKY9</accession>
    <name>A0A8J5JKY9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Organic cation transporter protein-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Orct-L5</name>
        <name evidence="7" type="ORF">Hamer_G005813</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKY9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7157390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="437" mass="48350" checksum="17E449FC6375F0F8" modified="2022-05-25" version="1" fragment="single">MAIKFDDVLLRLGMGRWNLPVILIISYWTMNVPSHTLGGAFLAPAIDVTCILPDHGLPKITSLDGSNQTTVDQCVYLEETKEGALKERPCTQWYYDNSTFITTITSEFNLVCEHKVWRATFQSIYLFGLLVGSSINGFFSDTFMDESPRWLIVQGQHDRALKVLEKAARLNKATLPPRDQLLTMMQNIASEAESVPEKRRHQRGLTKVMGKFLDFARSYMILVRTRRMRRYTLAMYVCFTVTGLGFYGLSLSGSTLGINLFVFMALSGTAELPGKGLSGVIVERFGRRNVNIICYALTALSLLAVPFVPTGSTWLIAVLSLLGKITISFSYTIIFLHCAECFPTEARTRGLGTSTIMAQVGSVCAAFVVEYLGSVAIWAPSVLFGMSSLVASAVMLTLPETRGAALHDTVVTLEARPSNSRSVRKKNQMRKTAETTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JL67</accession>
    <name>A0A8J5JL67_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DDE superfamily endonuclease domain-containing protein 44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JL67"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="116"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="245" mass="27648" checksum="BBE393A2734A0D92" modified="2022-05-25" version="1">MRPFAHLSAVYQMPKEAEAAHAGSRHKIIDNETLDLIVMLLEANPMMTLREIKEEVMDIFPTKPHFSEVTLSRYLEGELISLKMSRDSPAERNSPAVKEARHAYATWMLATGLQQQLVYIDETGFNLWTKRTYGRARRGERVHRAVGGQRGRNTTVIAAIAEHCGILYHEIHYGSVTKEVFSDFIASLAAIIGDARSILVLDNSPIHNGIAAVYPELNFKFLPPYSPCLNPIENCFSVFKSYLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLK5</accession>
    <name>A0A8J5JLK5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Photoreceptor-specific nuclear receptor-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NR2E3-L2</name>
        <name evidence="5" type="ORF">Hamer_G014829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035946">
        <property type="protein sequence ID" value="KAG7157964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLK5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="6"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7157964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="193" mass="21191" checksum="7A2DFBFDACC1D4B8" modified="2022-05-25" version="1">MGPHMPPVSSCSSSSSSGASYMEAAPLWDPLQESVQETAARLLFMAVKWAKNLPSFSSLPFRDQVVLLEEVWSELFVLNAVQWSLPLPTCPLLSPSAHAHTLAHAHKAAQAAHDILRGLKDSAQVESLQDQAQVMLSQHVRAHYPARPARFGRLLLLLASLRSPPPPRVQALFFTATIGNTPMEKILCDMYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JM63</accession>
    <name>A0A8J5JM63_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G025803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034339">
        <property type="protein sequence ID" value="KAG7158838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JM63"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="89" mass="9682" checksum="BF7670C972394CB6" modified="2022-05-25" version="1">MSRSMPSQGDGGAVGLTGSIQVHFDVVDGCRFQKVARVIAEFESSQAGQTKGCFTIARANQHSAGQSFFRMLILTLIHGRNETHLKKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMJ1</accession>
    <name>A0A8J5JMJ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Voltage-dependent L-type calcium channel subunit beta-2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Cacnb2-L2</name>
        <name evidence="12" type="ORF">Hamer_G001629</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calcium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMJ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000023">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000584">
        <property type="entry name" value="VDCC_L_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11824">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01626">
        <property type="entry name" value="LCACHANNELB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="Guanylate kinase/L-type calcium channel beta subunit" evidence="11">
        <location>
            <begin position="79"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7160396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="348" mass="38283" checksum="768EDADEF17D13A2" modified="2022-05-25" version="1">MALKGHLSVAAPRLSANNLTIPHTGLDLDNGIDSNLGDDSDSLGNSKGKTSITTPPAKEKRKPFFKKQENIPPYDVVPSMRPLVLVGPSLKGYEVTDMMQKALFDYVKHRFEGKVIITRVSADISLAKRSLLNNPSKRALMERSNSRSSCIAEVQAEIERIFELARTLQLVVLDCDTINHPSQLAKTSLAPILVYLKISSPKVLQRLIKSRGKSQSRNLNVQMVAAEKLAQCPPEMFDVILDENQLEDACEHIAEYLDAYWQATHPPLPPPQIQRPIPSPHTSPRSNHAQGNLMRTNSTPPEGVVGSSGLSLSSGRITSSEEDCLGGLTEMLLLLLYVINDFNPTHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTR3</accession>
    <name>A0A8J5JTR3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G019943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028706">
        <property type="protein sequence ID" value="KAG7161928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTR3"/>
    <dbReference type="OrthoDB" id="10577777at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035291687" evidence="2">
        <location>
            <begin position="21"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="190" mass="21394" checksum="3A0E5CFA4A21A26A" modified="2022-05-25" version="1">MKVLISVFLTVTLLVLSIHAHRHLHREGAQCGGSFRNKIEIITNLTLEECQLNDTSICLNNQMTCLKELKQELPSNITAFKIETKENITLCASNLQINITLPDSFLSTTSSEGNLFGGGRGPHGLGRGSRRFRRQSWSRQYGRSRGRHHGRPENLLRLLGIPDDQLLPMISCLMELSGLMDTYRVCISQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUU6</accession>
    <name>A0A8J5JUU6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pro-resilin-like 117</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G019680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029207">
        <property type="protein sequence ID" value="KAG7161489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUU6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7161489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="321" mass="35795" checksum="D30E8B03B07F7284" modified="2022-05-25" version="1" fragment="single">KSYPLPSRLPPSPISPSLPHPFLFHNSCPKSLSLSFFSFLPFSFPFFLFFFLSSFLLYLYLPLLLSHSPSIFFLTLSSSFSPLFNLPHTRSLVPPFLSDFFLSFLPISLLRPFSLSPPFSIHFLLFSVSPSSTPLFLYLLILPSSFTLFSLSVLPLPLPSLPHHPSTFPNTPPSYPISPTSPPLPFTNQGPPPNLLLGSGVYKSESNELQPHSSTSSPTINTTMKYTLILLAACVVVLVSGRPQQVEEDYPPAKYSFEYRVEDNESGNSYGHQETRDGDNTEGRYEVLLPDTRRQIVVYNVNGEGGFDAEVTYEGEAVITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVS2</accession>
    <name>A0A8J5JVS2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">METAP1D-L</name>
        <name evidence="8" type="ORF">Hamer_G004327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6"/>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVS2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF8">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="216"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7163226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="452" mass="50194" checksum="1066D25E83A6A49E" modified="2022-05-25" version="1">MKLMMWTRKILQKMLHPLDVFPSASVNFKSFLETPRTMRDKINYSSKLNFRTIFIADDDVCKATLIAAKTGREAECCQQEEKDLYQSISLQFDNLYTLNKIYRRRKLCSVNSKTLLDNYKSPVSHCIRTMTTLSSPAASHLLYSAPLVTQTQQNRGIWDIFKRANFGSYAVLDNVGEVSAAQLVPSHISCPPYFKTGEPSTPPSGPEIKAEWQVQAMREASYLARTVLNTVGEHLQAGMATEDIDILVHNKIIESGAYPSPLNYMGFPKSVCTSVNNVACHGIPDDRQLLDGDIVSVDVTVFYNGYHGDCCETYLIGNVDELGHHLVRAARRCRDEAIAICAPGVPFAAIGAKVEQVADQEGVTVVPCFIGHGIGKYFHGPPDIYHCYNNYPGTMEAGMTFTIEPIVAQGKEDALILEDGWTAVMLDNGRAAQFEHTVLIVEGGHEILTEYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW30</accession>
    <name>A0A8J5JW30_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Wnt-1-L</name>
        <name evidence="11" type="ORF">Hamer_G010902</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW30"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF91">
        <property type="entry name" value="PROTO-ONCOGENE WNT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="134"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="383"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7162223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="570" mass="65493" checksum="1827F4BE4C9F1478" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW75</accession>
    <name>A0A8J5JW75_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tigger transposable element-derived protein 1-like 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TIGD1-L33</name>
        <name evidence="6" type="ORF">Hamer_G007177</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW75"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF26">
        <property type="entry name" value="TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="86"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7165360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="570" mass="64364" checksum="A1CDEE8992BA6840" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWG5</accession>
    <name>A0A8J5JWG5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kv channel-interacting protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Kcnip2-L</name>
        <name evidence="6" type="ORF">Hamer_G025064</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026948">
        <property type="protein sequence ID" value="KAG7162835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWG5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF167">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7162835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="186" mass="21262" checksum="12339B09C5F069F8" modified="2022-05-25" version="1">MEILEQEPRYRPEDINALCRTTHFTRPELQRLYRSFKDRCPTGVVREDAFKELYFQMFPKGGSLNDRLKWIFTLYDLNGDGCITRQEMTDVVQAVYDLMGKHTDTPVDEQTVGQKVEALFTTLDLNKDGVITLDEFTEACSQDSTIAYNIDAMLHCDVTALNPGDVTTTTTNDGITPDHPSRTLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWJ9</accession>
    <name>A0A8J5JWJ9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative masquerade-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G004920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWJ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041515">
        <property type="entry name" value="PPAF-2-like_Clip"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18322">
        <property type="entry name" value="CLIP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035307722" evidence="1">
        <location>
            <begin position="23"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="PPAF-2-like Clip" evidence="2">
        <location>
            <begin position="34"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PPAF-2-like Clip" evidence="2">
        <location>
            <begin position="111"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7165136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="262" mass="27239" checksum="C7E895B9D0F96FEB" modified="2022-05-25" version="1" fragment="single">MRTGKVLYIVAVIAVVMPRASHQQQGAVGVLPAQSGCPQHHECVDRNLCLNGKVITDGSGLLDVRITSSVLLGTVQHCLEPHKVCCSVPGTVDPNRHPVGGIAGSTGVTTSTFCNEGHDCVPTYLCHDGELNTSGIGILNPRNRPTSVTDCFLEPNAPAGVCCTPHVPAPLQTCPGTRVCVPNHQCTAQGTINIAGTSILDVGLHHRCYLEGGGELVGVCCAPPPPVLICPGGETCLVSDLCYYEGNTASSSNSVSVHSHHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXI5</accession>
    <name>A0A8J5JXI5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 394-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Znf394-L1</name>
        <name evidence="9" type="ORF">Hamer_G007269</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXI5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000417">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7165436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="185" mass="21297" checksum="B1FD5D4CA6976DA0" modified="2022-05-25" version="1">MMGLLPLHRREYRVGFPAVSGVDPQYRCCWCGKASTTRYDYDKHLRTHTGEKPFVCPICPFRTGDRSSLSKHAGGSLDVGRDFRGGANPMFVVEGVEVLPCPLCGRLLHTRSRFRSHLEYCRRAANPQFACQTCHKSFAYRKDLEKHVRTHTGERPYPCHYCTYRFADRSSLVKHRRRHHPAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXL3</accession>
    <name>A0A8J5JXL3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXL3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="475" mass="52336" checksum="C04CAF115BC690E2" modified="2022-05-25" version="1">MGTAFAFLLQVTTPKVKGVKVSKMTKDVNPPPLYSRWAGVGSEVIVTESSQVNGSATTRCPTIIRSSSSDASSDGSDDDEPLFMRCNSIESIIHQSPEGSPEGRHVPLGTRRSWPHQTSVDQCPPQQTRLARSLEDSRVHGDVTLDIGSSTDDDICSFSSDDDHILYGNMGIGVTETEPNDALDDELSDGLFPDEDEIDEDDVECGESGEAELNSQDWEVQLLARQLAEDQRGFARKVDRDIAEGRLDSALADLHEALATDNLGPLTDEDLLRLEKAVRREREKLRRYARVYSLDERPLLEDQFTSLYRSRSQLLLNRSSELCLAGPTERRLSLLLEQLTKMSPAEQFLLDRLVYTTDRKRRLSRQRSLCDEHLASYNTDRIPISNRSNRSLANRRSMSVCSPPPGTAPPAPLKEATLASPGPLRERGPGGESGPPTVSAMLASLQRSVAAIRGRGSGNNQSSHKEGAPLLKPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXY8</accession>
    <name>A0A8J5JXY8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor che-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">che-1-L</name>
        <name evidence="7" type="ORF">Hamer_G011818</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7165912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXY8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF109">
        <property type="entry name" value="ZINC FINGER PROTEIN 845-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7165912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="195" mass="22419" checksum="B4A9A8AE5EB53E2C" modified="2022-05-25" version="1">MVMMTTGQDPGLNCPFSLIGATGTRVVSRSGHPTSQYVRVCNPPEEMLVQGSDDGLKLYCDQCSYKARDSTNLRRHKRIHTGEKPYACSYCNYRSTQSNNGSEVVDAQGVARKLSHYICQHCGYVARDKTNLRKHLYTHTGEKPYACMYCFYKTTQNSNLRTHIKRHHQQYIPRDEKFVEQFSGGDVFMLERMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZK4</accession>
    <name>A0A8J5JZK4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">XKR6-L1</name>
        <name evidence="9" type="ORF">Hamer_G005103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZK4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902742">
        <property type="term" value="P:apoptotic process involved in development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043652">
        <property type="term" value="P:engulfment of apoptotic cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070782">
        <property type="term" value="P:phosphatidylserine exposure on apoptotic cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF10">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7164703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="504" mass="56315" checksum="AD1895E18A2E5E37" modified="2022-05-25" version="1">MTSPRSGPTREGEESQSYPNMKNIASSQNEGSLNLYPCLENMNLGTPPGSRRSNVTNKSGGDTGMATPSTAPLSPLTARRLRELGPRVEEMTTQLATATSGAGKVLAAGVRNLTAQGTKTLMEPMEKSKFGWLDALMALFSIGLFYFDVVSDIFVAYYMYDDPETEVWFRSTVLFLVIPLLVVNAFSIYWYWFDEHVCESEEMCYMLPKASPCVWGIRIITHLLLQGTVLRFQTKCAEETERLTETGIVTDAVRVAEAGIVRGRKSNSSINPAPTIEPLCNSYHSRWIHAERDAANVDVLSSMLQDAPQLILQLYIMTHTIPDQALQGHISQTLMMQILSVTASVVAMALSVLCFALFASKYLIVFLALVSCHWLASSVFILIQLVCSPDPRLMGTTFSHDIKRGPCNRLDDIAFSAVFGLILLYTFMNVGGRAPKIQFGVYHFFRLVEEACMLAFWYLATDGDMWYHWLPLVLVSLSCVLGIIFFSLYYCCVNPDRDRRYLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZV8</accession>
    <name>A0A8J5JZV8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Eif2b3-L</name>
        <name evidence="12" type="ORF">Hamer_G020834</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026066">
        <property type="protein sequence ID" value="KAG7163918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZV8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="10">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="11">
        <location>
            <begin position="289"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7163918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="396" mass="43384" checksum="FA12AEE76ABDBD07" modified="2022-05-25" version="1">MHLEAQAIVLAAGPGMRMTTLTNHTPKCLLPVGTLPMVCYPLQILQEAGFSEVTVVVSGGEEQRMSKVVEQYGLKLNLDIAPVNTSHDPGTADSLRHIASKIKRSVDDVVIVTSDLVTDAKLQPIMDQHRSSGAALTMLTANQQPEFLKATPPGPKTKPTINNDVICTQSKTGRLMYAVAGGDYDEVISLHNRVMKSAKSLNVSTSTVDAHLYIMKRWLVDYILSKESLCGEMGSLKAEILPHIISRQFTKEPIKQRSERKLDPSFGQSFQMHSLFEQVYPNSAWSIKHPSADVQEKAQVSDDSLIGSGSVICEKTNITSSVIGNHCRINSFVRILNCALGDHITIAPGCVIENSLIAANVERKCTIKNCIVTDPNKIEENKTYTNEILEAVQDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K004</accession>
    <name>A0A8J5K004_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G005466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K004"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="74" mass="7601" checksum="C0C56B04244CC5C4" modified="2022-05-25" version="1">MVAVPSHTHATPSTGSPSTTSNTTPITTINYESNITITSASPPLISTTTPSPTPQHTTPRSPSSSSSHVDCPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0V6</accession>
    <name>A0A8J5K0V6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative facilitated trehalose transporter Tret1-2-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Tret1-2-L9</name>
        <name evidence="2" type="ORF">Hamer_G026729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020597">
        <property type="protein sequence ID" value="KAG7168107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0V6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="204" mass="22794" checksum="6646E2294D0075E1" modified="2022-05-25" version="1">MHLGQRVPFRGHAFLGDVSGLVFTPKVWLPCCSASCDSPTSCISCLQQPRRGGVRKSSGVRLMRFGGRWAAIWFLLVYIIGAVVAEHNTVCGCVTAILPFTGCSSCRTPHDDLLPEAALRRASARFSCFRGPRYDSQPEFDDIVDQFKETTSNNTEAVSQLRQTREQSVLRRLPFLIFLVVLLQFNGKVSIPRTLCHLRHPTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K152</accession>
    <name>A0A8J5K152_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020459">
        <property type="protein sequence ID" value="KAG7168197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K152"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="213" mass="23730" checksum="506D28BB62D70A7C" modified="2022-05-25" version="1" fragment="single">VKRMKRPSSIMLEPIMVAFISVWLVMTFASIVDVIIPYGFYIMLVTNLLEGIILVTVLGLYKSIMKLLAFDVGRAVAPILPYVTLGGQELLWPASRNQVSPMVVTKGVFPSSTFEEEDMSGRRDTTPHSAYRREMIGPLAVKDSLHRHLQHLAAVSCMVEDIKNELMSIVAWPFSVLLLGQGLVTITTLYETLMGNGFVLYSSCCIYGFLSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1T5</accession>
    <name>A0A8J5K1T5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta,beta-carotene 9',10'-oxygenase-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Bco2-L2</name>
        <name evidence="6" type="ORF">Hamer_G011881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7165963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1T5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003834">
        <property type="term" value="F:beta-carotene 15,15'-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7165963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="581" mass="65996" checksum="4C479E099FA8E760" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1V6</accession>
    <name>A0A8J5K1V6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G004756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1V6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7165013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="432" mass="42986" checksum="5A5712101484B11A" modified="2022-05-25" version="1" fragment="single">MSLRRDLEEVLASALIELVAAVRASAAAAAAAVVVVVVVVVVVVVAAGKFVVVVSEDAMSAALSMLGLFANCSKSRDAKRSPIPEESGAREFPSGATPDDVPISPAWRSPLEGVFGVTITCIGATGGGTISTGRCGDQIISEEQVSGGEQVNVGDQVSSRDQVRGGEQVCRGEQVNGGEQVSGGEQVNVGDQVSSRDQVSGGEQVSDGEQVNFGDQVNSGDQVSSGDQKSSGDQESSGEQVSSGEQVSGGEQVSGGDQVSGGHQMSGGDQVSDGDQVSSGDQVSGGDQVSGGEQVSGGDQVSGGDQVSGGDQVSGGDKVSGGDQVSGGEQVSGGEQVSRGEQVSGGEEASDGEQVNIGEQVNSGDQVSSGDQVSGGHEMISGEQVSSGDQVSGGHEMISGEQVSSGDQVSGGDQLRSRDQVSGGHHVSSGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K366</accession>
    <name>A0A8J5K366_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuromedin-U receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NMUR2-L</name>
        <name evidence="12" type="ORF">Hamer_G013395</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015640">
        <property type="protein sequence ID" value="KAG7169757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K366"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="402"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="327"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="527"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7169757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="561" mass="61239" checksum="C3982924FBF044D6" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K528</accession>
    <name>A0A8J5K528_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retinol dehydrogenase 11-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RDH11-L6</name>
        <name evidence="2" type="ORF">Hamer_G027273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015813">
        <property type="protein sequence ID" value="KAG7169576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K528"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="274" mass="30681" checksum="83D3B2E274EB333A" modified="2022-05-25" version="1" fragment="single">MLRWCYTCCRGSVAPVELVGVSAAGGGSTDFLLLWCFNTTGGRQDGRHHRHKGISSSEATSPEMTFLVVERESEVELDKLPRRSVRKFRQEAAGPGLKAASGRVVTITSFGHKWVKEVKDLDLDGDLKFQISRPLRTLEIYAATKLMNANFTMELHRKLEGTGVTTNCVHPGIVNTDIFNCMTSRVWYGFFVKLFVRAYAKTMNHRTSGVPIDTCSEKQGQRDPDLECGPVWSQLLIFKNAPNKEELIPRSRIDGSRKQNLNSRFGDGCWCSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7J4</accession>
    <name>A0A8J5K7J4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agrin-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Agrn-L7</name>
        <name evidence="5" type="ORF">Hamer_G018447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7168013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7J4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF45">
        <property type="entry name" value="FOLLISTATIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="83"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="140"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="232"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="279"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7168013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="426" mass="46201" checksum="7F6C39D8C0033054" modified="2022-05-25" version="1">MFTGAEKLDTLATIFETLRTRAETRLCRMDCPDSVRPICGSDNVVYRNSCTFKRALCANPRLEKKNDGPCTSNTPESFPSEIALSTTVCKDECTKIYEPFCGSDGRTYNNKCILEAASCRNRNSGGRGITAVRRGVCEGDQNCHKDCGSTYRPVCGTNGVTYDNRCEQEIAACRNKEIAVRYEGVCVASSSSSSSSIPIGKPVVLSLPSVQSSQGASAAVVTGKDCPDSCLPGFQPVCAKDCNIDCYRDNEPVCGNDGKIYENDCFLAVARCKDNAIRKVDISECSQQRRRACEVTCTDVSQPVCGSNGVTYQNPCKLEAATCFNKGLLKLNDGACHVEEEGCLLSIRVSTGHAVSTSLTAEDVSTGTDVSTANISTLNDNQHIGVSTNKWYQHFKRCQHSYHQHNQRSQPKLLVSAPKALKISTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7K1</accession>
    <name>A0A8J5K7K1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Myb/SANT-like DNA-binding domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Msantd-L2</name>
        <name evidence="3" type="ORF">Hamer_G021169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013493">
        <property type="protein sequence ID" value="KAG7170791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7K1"/>
    <dbReference type="OrthoDB" id="6723674at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="250" mass="29344" checksum="699E44EBEAED4F8B" modified="2022-05-25" version="1">MSIGKVYQKWSRDMVHLLLSEIRHLWPKFRNKKYTMKMLYEDASTKLREYGYEVSAYRVEKKWHNLASTYRNVLNKMHNYGEESITRRHEYFEAMHELMGNMNAVRQKSSVSPLEEMLPGTSQTRSSSPLSPASTLASPPSSPEPSRKRIRTDEHSSPKIILIPAVQNHDQVYPEQSVPIQTQVKGHIKQQIIDDAEEQESRREWREWKRQQELINVQREGNRVLENIDNNLVAIRKSLDFIVQKLSNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7U9</accession>
    <name>A0A8J5K7U9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G002565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7U9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823:SF1">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="152" mass="17004" checksum="1CDFDF579619F38F" modified="2022-05-25" version="1">MNYPKVPVKKKPQEFDGKVSWKAYQAQYELLAEQNGWDDKQCAVQLATSLKGAAMEVLSQLTGKERSSYMSLVKVLERRAYPGASPDLLAMLSRDQFVDALDNTQLKIQVKQSQPATLQEALARALELESYVRSSLPNCRMESSSGFKARKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7Y6</accession>
    <name>A0A8J5K7Y6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Atg5-L</name>
        <name evidence="19" type="ORF">Hamer_G005606</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in autophagic vesicle formation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Conjugated with ATG12.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Forms a conjugate with ATG12. Part of the minor complex composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa); this complex interacts with ATG3 leading to disruption of ATG7 interaction and promotion of ATG8-like proteins lipidation. Forms an 800-kDa complex composed of ATG12-ATG5 and ATG16L2. The ATG12-ATG5 conjugate interacts with RAB33A; this interaction is bridged by ATG16L1 and promotes ATG12-ATG5-ATG16L1 complex recruitment to phagophores. Interacts with TECPR1; the interaction is direct and does not take place when ATG16L1 is associated with the ATG5-ATG12 conjugate. Interacts with DHX58/RIG-1, IFIH1/MDA5 and MAVS/IPS-1 in monomeric form as well as in ATG12-ATG5 conjugate form. The interaction with MAVS is further enhanced upon vesicular stomatitis virus (VSV) infection. Interacts with ATG3. Interacts with ATG7 and ATG10. Interacts with FADD. Interacts with Bassoon/BSN; this interaction is important for the regulation of presynaptic autophagy. Interacts with ATG16L2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Preautophagosomal structure membrane</location>
            <topology evidence="2 15">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ATG5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022531">
        <property type="protein sequence ID" value="KAG7166494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7Y6"/>
    <dbReference type="OrthoDB" id="272162at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043069">
        <property type="term" value="P:negative regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.190:FF:000001">
        <property type="entry name" value="Autophagy related 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.620:FF:000001">
        <property type="entry name" value="Autophagy related 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000100">
        <property type="entry name" value="Autophagy related 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="11 15" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="6 15" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="18">
        <location>
            <begin position="11"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="17">
        <location>
            <begin position="121"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="16">
        <location>
            <begin position="185"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG7166494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="268" mass="30993" checksum="E9791F1EDD73688C" modified="2022-05-25" version="1">MAEDREILREVWDGRVPVCVQLASEDCSTLSAPDSYYLMIPRLSYLPMVMDKVRKHFLRFTSQELQEAEMWLESDGTPLKWHYPVGVLFDLHCGGAALPWSLTAHFSHFPDQDLIRCPTREVVESHFLSSLKEADGLKHRGQIITNMQGKDHKQLWMGLCNDKFDQFWAINRKLMECTPEEGFKNIPFRLHSLCKPPIQRLIKPLADDGRKITLGDILQDYMPNTLQEGDRVIIQGIEAPRDTPIQWLSEHLSHPDNFLHICYIPAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8A9</accession>
    <name>A0A8J5K8A9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pogo transposable element-like 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Pogo-L24</name>
        <name evidence="4" type="ORF">Hamer_G002460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8A9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018586">
        <property type="entry name" value="Brinker_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09607">
        <property type="entry name" value="BrkDBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="TrpR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="59"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7168418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="243" mass="28266" checksum="BE11755FF811D351" modified="2022-05-25" version="1">MAPIVKRRRYEACFKLKVIAYAQSHNNCAASREYGVTEKMVRDWRSKEHLLRSMPRNKCAMRRGTAHWPILEKHAVDMVHEQRQNGYIVSRNMIRMWALKWAKQNQEHSKDFKATASWCSRFMERSNLVLRQKTKIAQKLPADLNCGNMRAPELDVLCDFVIKAWNDINVETVIKTFKKCGISNSMDGMEDDMLWEDEDETEAEATSSDLEFDPYDDAAINVSQDVLEELMISDVDDVDFEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KBH5</accession>
    <name>A0A8J5KBH5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Snrpg-L</name>
        <name evidence="12" type="ORF">Hamer_G012329</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KBH5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="186"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7170096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="259" mass="28557" checksum="19ADA32DC39A8A21" modified="2022-05-25" version="1">MSKMRIDNAMKSTTTANVGSVKRMENVEVFINKKCIDIDGDLVQRLSGCTLMENGGTYSVGRGRGRRWSSTSPMGRDSSSRRYHKASRVSSMEQNRPEEIMKTPSSTRGIRRHSSNSSLCLAVSAAPAPRAQKTSLSHVTPAAAPSGSQRQKGLQVKRKKQVTATNSIPPVKQHCQPRQRSLPPVITRFNFAPYMDKRVMTKLNGGRVVEGTLRGFDPFMNLVVDDGVEVRKTGDRVRIGVVVIRGSSIIMLEALDRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KEB0</accession>
    <name>A0A8J5KEB0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G018025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015512">
        <property type="protein sequence ID" value="KAG7169780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KEB0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7169780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="119" mass="12745" checksum="B9AF8078A9989618" modified="2022-05-25" version="1">MAAADEYSTTSHVLQLCLALQDRLEKVEKEVQSLKGENLALKLVLEEKKTFASVVKDGEVEVDSWKVVAASATKCAIKRHSAVDLNNRFSTLSDECEEGASNTTSATPSVSVERGSSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KKT9</accession>
    <name>A0A8J5KKT9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reticulocyte-binding protein 2-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Rbp2-L8</name>
        <name evidence="3" type="ORF">Hamer_G025002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015240">
        <property type="protein sequence ID" value="KAG7169839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KKT9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7169839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="507" mass="58400" checksum="16F7DCB12845EEDC" modified="2022-05-25" version="1" fragment="single">NNRRHHSHFSPGRCPLLPSPLRLSPLRLFPTPPLPHSASPPLNPSSFPPPLPMSHDEALPHSSPQDVINQRAASLVHSAVSSPQWVGGTRSTLSSLRLNGEQIASLLRPSEPITNCPDKELINDMIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERREGQTRIMRRSIGRRRKKKRKSKKKKEEEEEEEIEKEEEERYEEEGRKRKNGRSWSRRKRGGGGTTKGRSKRMKKKGRSHPQQEEEEEEEGEEEEEGEEEEEKKKQEKDEKKEEEEEEQQEEEVDGKVDKEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJB5</accession>
    <name>A0A8J5MJB5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G022461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046756">
        <property type="protein sequence ID" value="KAG7153531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJB5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="318" mass="36067" checksum="B79ED2A59DF44F29" modified="2022-05-25" version="1">MEIESYRILEAETYRILRQNPIDSEAESYCLLEQNSPSPEAESYDLLGQNLLCILGGILPYSGAESYRIRGRELPSSGAESNRLLERNLRILRRNPTVWGGIPTVFWGGILPYSRGGIYCLLGQNPTYSGTESYRLMGRNPTVFWGGILPYSGAESYRLLWAESFRIFGAIVPYSGAESYRLLGQNPILFWDRILPYSGAESYRILRRNPTVSWAESTTAPGNPTVFKGVILPYSEVETYRLLERNPTLFGAESYHSGRNPTVFCSKNTILFKLNPTVFWGGILPYSEAESYCILRRNPTVSWCEASNRNMRRNPTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJU7</accession>
    <name>A0A8J5MJU7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neuronal acetylcholine receptor subunit alpha-7-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Chrna7-L8</name>
        <name evidence="3" type="ORF">Hamer_G023281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045124">
        <property type="protein sequence ID" value="KAG7154133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJU7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000058">
        <property type="entry name" value="Nicotinic acetylcholine receptor alpha6, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="45"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="130" mass="14543" checksum="356A15FA93EB5563" modified="2022-05-25" version="1">MTNERSSKSLLANVLDIDDDFRAHTLPHTHTTNTNNTAGYIRVPHGGHSVDDSHLVHTCMSSCTRELNLILKEIRVITDKMRKDDEDGEVANDWKFAAMVVDRLCLIIFTFFTITATVAVLLSAPHIIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKM8</accession>
    <name>A0A8J5MKM8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043558">
        <property type="protein sequence ID" value="KAG7154896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKM8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="233" mass="25662" checksum="EFD4465E9AA4775E" modified="2022-05-25" version="1" fragment="single">MKENAKTVSSNEEEHPPPAASSALPGSPTASVSTPPPGTPFAPALLPQLKSAETKRQQPAELKNQVLETVCSIPAPGFQEVTREDLEELMQEGNTNDVEDLLEDEEGGESGDAAIDAGETEQRKATTQKLSLLSGVCTSLQEMIQDIEIDSGEREQLIGSVKSISRKYQMQYNERVNARQQSLITRFLSQRRPAEEDQQREVEVDEDIDDIGEMPEDFDFAEFDEVLAEVGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ML26</accession>
    <name>A0A8J5ML26_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450 3A11-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Cyp3a11-L2</name>
        <name evidence="14" type="ORF">Hamer_G021227</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041527">
        <property type="protein sequence ID" value="KAG7155483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ML26"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7155483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="399" mass="45403" checksum="E24127806127862D" modified="2022-05-25" version="1">MGVEAWLILVVGVLGSWLLLAMGVEVWMLLMVGVLGSWAYTRKRHNYWSARGVSTPPYLPFLGHMHRLFSLTQSKWVYFWEVYRKYGGDKFCGLYEMHTPVLFISDPHLIKLICVKDFEHFVNRRDIGTFRKNSVVNKMLFNKMGSEWKALRSVMTPTFTSGKMRGMFPLICDKADALVSSSLKECAEKSYADMKYNFGSFTIETIASCAFGIDCDSKSDKNINFAKQANNIFAFSLTNLMKHAITRSVPTLSHALGLNKDQPEFLFFESVAEKAIQLRREGQRRGDFLDLLIEARVAEDSFIKNNHSTVNNDHTALTNNHTQAPSKCVLDDDTIIAQSVLFLLAGYDTMASTLTFTSFLLAKNPTHQQRLRRELQDLVQVHGDVTNQVARDGSDYTRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLM6</accession>
    <name>A0A8J5MLM6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Structural maintenance of chromosomes protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Smc6-L</name>
        <name evidence="15" type="ORF">Hamer_G012124</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLM6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="259"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="93"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="240"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="462"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7155974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="885" mass="102609" checksum="FFC6E9B2AE19207A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLN2</accession>
    <name>A0A8J5MLN2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G032032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040407">
        <property type="protein sequence ID" value="KAG7155795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLN2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="96" mass="11183" checksum="C80655BD0C258F1C" modified="2022-05-25" version="1">MKIKIESGEPDFIVATHVAKNLESWGVNPSNVEIHMKGLTFLRAENIKVRDMSTFDFIIGYGFLRGYRCALDYEKKDLYLQTSDRKVRSHLRTMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLV3</accession>
    <name>A0A8J5MLV3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Translation initiation factor IF-2-like 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">infB-L28</name>
        <name evidence="1" type="ORF">Hamer_G032099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039359">
        <property type="protein sequence ID" value="KAG7156214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLV3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="234" mass="24375" checksum="D2D87C3A486CB77D" modified="2022-05-25" version="1">MVRCFSCGVGLHNWEENEEPWNVHARWSSSCEFLLLSKEADFIKKVQDQTPPYKQSCCSIGGWYVDCCTIGGPDVDCGTIGGGGPDVDCGTMGGPYVDVDCGTMGGPYVDVDCGTMGGPYVDVDCGTMGGPYVDVDCGTMGGPYVDVDCGTMGGPYVDVDCGTMDGPYVDVDCGTMGGPYVDVDCGTMGGPDCGTMGGPYVDCGSYVDCYFILGFFILGSMSGCCSIGCPYVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMV1</accession>
    <name>A0A8J5MMV1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Sdr16c5-L1</name>
        <name evidence="13" type="ORF">Hamer_G005759</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMV1"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7157343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="344" mass="38679" checksum="18EAC8DD0F45DBD9" modified="2022-05-25" version="1">MNGSVMQELHPLGLTSSRRRSSARDVTELEPNVPANPTRYERFVQVAKIKAWELSLVLAGFIILNVKAIILLVMDVYRLIIPHEEKVLQGQLVLITGAGQNLGRELSLQLANFGAKLILLDINEEQNETTADMIRDAGGEAHTFTCDVSDHKSVASVGAKVRKEIGHPGYVFNNAGTYEYKPFLSHSAEDIQRLVNVNLLGNIWVTREFLGHMIQLNRGHIVCISSVLGFIGRNNVVPYCASKFGVKGMTEALAEEMRMERRSGVRVTAVHPFLISNIDDVTPNLKFPWLFEILEPSDAASRIINGVRRNQEEIFLPEKLKPFMVFSKVLPRKLRRLFGDYMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNA8</accession>
    <name>A0A8J5MNA8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G019184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037402">
        <property type="protein sequence ID" value="KAG7157550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNA8"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="525" mass="58899" checksum="BFA9F021DB65F934" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNI1</accession>
    <name>A0A8J5MNI1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dhx9-L</name>
        <name evidence="15" type="ORF">Hamer_G021468</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010036980">
        <property type="protein sequence ID" value="KAG7157775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19854">
        <property type="entry name" value="DSRM_DHX9_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19855">
        <property type="entry name" value="DSRM_DHX9_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000026">
        <property type="entry name" value="ATP-dependent RNA helicase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000028">
        <property type="entry name" value="ATP-dependent RNA helicase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000677">
        <property type="entry name" value="ATP-dependent RNA helicase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000284">
        <property type="entry name" value="probable ATP-dependent RNA helicase YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044445">
        <property type="entry name" value="DHX9_DSRM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044446">
        <property type="entry name" value="DHX9_DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF119">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="46"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="210"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="430"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="671"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="122"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1186"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1281"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7157775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1307" mass="144964" checksum="98B37262DA108BF0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MP71</accession>
    <name>A0A8J5MP71_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABHD14A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">abhd14a-L</name>
        <name evidence="5" type="ORF">Hamer_G011392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. ABHD14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MP71"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197">
        <property type="entry name" value="PROTEIN ABHD14B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="121"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7158723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="379" mass="41704" checksum="DF31F608820DEDC4" modified="2022-05-25" version="1">MAPSLMLPKLTMTPFRVMALVAGVAAVCLVFSALTTTGRQAKLGKAFEQVSTLDKRDLSGRTMAEPNFWRNFDFRSEQIPSQVNEAAQKVHVTNHTINIMGSNTFYREAQPPEGVASSGEVVVLLHGAAFNSKTWLDLHTIDLLAGMGHRVIAIDLPGFGKTPGPLTGDRADYLHSLLSNLKVTHPILVSPSMSGQFSILFINKYPQDLAGFVPVAPVSTQLIKEKAPELRWLKYAGFGHSGRQELGPELRRTWLQSFLIALDLPPCIVVSPSFSGVYSLPLLALQSHELDGFVPIAVDATDEIPVNFLQTLMVPTLIIYGENDRTLGHSSRDDLLRIPTSQDIEIPQAKHPAYLDNPNLFHTLLYNFIKQVHAHRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPM8</accession>
    <name>A0A8J5MPM8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pro-resilin-like 54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G016505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPM8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035275935" evidence="4">
        <location>
            <begin position="16"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7159126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="141" mass="15629" checksum="F8BC3A7D0DFF6321" modified="2022-05-25" version="1">MELFFVTALVVVASADNLPSYNPPPPTPSYNPPTPSYNPPRPSYNAPAPSGPAQYNFNWAVKDEYSGNDFGHEETRNGYDTQGSYYVLLPDGRLQRVNYNVNGDSGYVAQVDYEGEAQYPAHQPAPRYQPTPSYQPTPSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQ18</accession>
    <name>A0A8J5MQ18_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">Fgfr-L</name>
        <name evidence="24" type="ORF">Hamer_G004113</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Receptor for basic fibroblast growth factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQ18"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000007">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000016">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000020">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000593">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF550">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15 24" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="625"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="234"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="332"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="426"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="731"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="765"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAG7159484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1043" mass="116575" checksum="D574369B815B31B9" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQN3</accession>
    <name>A0A8J5MQN3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Double-stranded RNA-binding protein Staufen-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Stauf-L2</name>
        <name evidence="2" type="ORF">Hamer_G012733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQN3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="410" mass="42684" checksum="ED2441F75F3A36D3" modified="2022-05-25" version="1" fragment="single">MDACAGAMVEGKLQKLHQKQAWSRKPSLNTDQNSAGKQMLLLEAGTTSRAAICCCYCWLSQTRRCPMIIPMAQVPMRMAQPSLVPPHQQRPPMMVSMTQPPPVSMQGLVSMAPMMAPAGGMAVMTQAMSHPDSGVGPDHHTLNAPYHHHHHPHHHHGPPGPHHPGPPPHHPSGPPQPPPTGPPPHTGPPHSQYHPGHHPAQAPHHGHPSHAPHHGPHHSAPHTTPHSAPHSGPHSGPHSGPHSGPHSGPHSGPHSGPHTGPHSGPHSGPHSGPHGGPHSGPHGGPHGGPHSHGGPHSGPHMGLHSGNSGSGPHSGPHGGPHGGHHGGPTHPQSHLQATATVAGPPHMTHPPHSVMHHSTPHQMGGMGSGGPAGMGSSPSSSHQQQQQQQQQQQQQQQQQQQQPPPPHHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQQ1</accession>
    <name>A0A8J5MQQ1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Psmb2-L</name>
        <name evidence="9" type="ORF">Hamer_G001545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQQ1"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 8 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7160328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="204" mass="23200" checksum="0B7FEFFED23373AB" modified="2022-05-25" version="1">MSLECLIGIKFDDFVLMATDMSHLQSIMVQKSDDDKMHTLSRNLVMAVSGEAGDTTQFAEYIAKNIQLYKMRNGYELSPSAAVHFTRHTLSTHLRSREPYFVNLLMGGVDPDTKKPELFFMDYLAASVPVKYYAFGYGGMFTLSIMDKDYTSNMNQEQAYELLKKCIAEIKRRFIINLPKFRVRVISKDGIKDLPHIVSVGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQQ3</accession>
    <name>A0A8J5MQQ3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Hairy Orange-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G012768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQQ3"/>
    <dbReference type="OrthoDB" id="7693256at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orange" evidence="2">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7160221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="240" mass="26426" checksum="92E74F01398685E8" modified="2022-05-25" version="1">MPVPVSPRKNDSSQGVDASTPEVGADPVQESAQSPAIPPSLNEEEEIVDPDVVAGYQDCLKETLRFLLEEEHLPEDHPVVTGLAAHLTREHAHVELTKLSHQLSSAIVDAHNTPSNVLVEEAPSANNATALRVPMTLNAGFEVTLVEDNSEDEEIVVLDDNEAMDEDEFEYINIEELSDSEDNSEYEIEGELEEARVTEALITDPELQRQLIRFVYQGCDLFAAPQPINPASYQGMVLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR00</accession>
    <name>A0A8J5MR00_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Annexin A7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ANXA7-L</name>
        <name evidence="4" type="ORF">Hamer_G012673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR00"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032509">
        <property type="term" value="P:endosome transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF233">
        <property type="entry name" value="ANNEXIN B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7160132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="312" mass="35555" checksum="19CAE2E503988C01" modified="2022-05-25" version="1">MAEQHDHPTVKTKIPMDVAGYVEGLRKAMKGMGTDEATIINLLTSCSSDQRQVVLQQYQSTFSRDLVKDLKKELTGHFEDIILVLMTRRNEYLAQQLHHACKKKNANTMIEMLCTAENSTIKSIKSAYERLFDSSLEEALTEATTETFQAVMLGMAAAERSDTYNEELSHSVAKKLYNDGLGLEEEELVKVLCKYSFRQLREVLVEYYKQADRTLGDTFDCQYTGNNKTYLKEVFQCLDNRFAFLAEELHKAMAGSGTRDQDLIRLVVTRSEIDLGNIKTEYENMYNKPLSKDIKGDTSGDYKKILLALLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR06</accession>
    <name>A0A8J5MR06_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031022">
        <property type="protein sequence ID" value="KAG7160670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR06"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="245" mass="26538" checksum="3267F147AFB758B2" modified="2022-05-25" version="1" fragment="single">TWARRVTGVSESWAGGGVGPGLRVVVRTLGTAGVMVSQRPWAGTLGTADPWARRVWVSVGTLGTTGSGVGTHRHGSGESQARLAGEGGVGTLGFDGWSESDPQAGGREVVRPWTVDLTAQTQHYNKTYDSPDYKVLYRTLTELLQDSYRTLFTGLYGYSPMTSPRLYLTPRMDLSVVVSPGARHILTGLSQPSSDLGVWGDWMEASRAPTPIKTRRLALKFCRRSNSSFSIKFKSSVDGRELVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSS7</accession>
    <name>A0A8J5MSS7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PSMB6-L</name>
        <name evidence="13" type="ORF">Hamer_G024868</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010027973">
        <property type="protein sequence ID" value="KAG7162247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSS7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7162247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="191" mass="20859" checksum="E0779FD83BD582C7" modified="2022-05-25" version="1">MQTSIMATEFDGGVVVGADSRTSMGTYVSNRVTDKLTRVTDRIYCCRSGSAADTQAIADVVSSHMEILEVKLGEPPLVQIAANTFKEICYNYRDMLMAGIIVYTIPLGGMMVRQPVAIGGSGSTYVWGHIDATYKPNMNMEETVEFVKNTLTLALTRDGSSGGVVRVAVITKDGVDRRVYLHNELPEFYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUK9</accession>
    <name>A0A8J5MUK9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pol Retrovirus-related Pol polyprotein from transposon-like 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pol-L18</name>
        <name evidence="3" type="ORF">Hamer_G005003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUK9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7164618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="243" mass="27399" checksum="5CE08A07D37E5159" modified="2022-05-25" version="1">MRAVFWTTEETQAFEEVKKALANATLLSHPHPGALLRLIVDASDTGVGAVLHQHIYGRAEPLAFYSKSLQPQETRYSTLGRRHLPREQWHLDFILKFTANIRHIKGENNVVNAFLRVFTLSADDSNASKLDFTLLDDAQQRNIDMQQLRTVDTGLQLRDVPLPNLKTLISDTLTNQLHWFVSGDTPRLYLVPASYTTKAELSEAGFHRQGTGRGNTCFRMPNDTWNATATSLRRSFQGTPPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUP5</accession>
    <name>A0A8J5MUP5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 40-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Hivep1-L</name>
        <name evidence="12" type="ORF">Hamer_G014488</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026055">
        <property type="protein sequence ID" value="KAG7164017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000594">
        <property type="entry name" value="Transcription factor HIVEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051969">
        <property type="entry name" value="Zinc-finger_DNA-bd_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944:SF2">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1435"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1463"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1910"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1938"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1983"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="261"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="398"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="466"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="634"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="976"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1347"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1514"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1659"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1772"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2067"/>
            <end position="2093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="665"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="690"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="976"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1347"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1370"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1382"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1528"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1779"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1816"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1838"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2078"/>
            <end position="2087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7164017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2194" mass="239451" checksum="177C2DA94A75D23C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVA3</accession>
    <name>A0A8J5MVA3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Alpl-L6</name>
        <name evidence="12" type="ORF">Hamer_G019420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="JAHLQT010024443">
        <property type="protein sequence ID" value="KAG7165233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVA3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7165233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="297" mass="32513" checksum="FE5D68BE84630471" modified="2022-05-25" version="1" fragment="single">TYNLDRQVPDSAGTGTAYLTGVKANKGTVGVSGDVHYKDCDASLLPENRLDSILKWAQDAGMDTGLVTTTQVTHATPAALYAKSADRYWQCDTKMIQENVIMGGGRQELGATPLQEVKLECPRTDGRNLVEEWAADKEARGATHAYVTNTQQLLDLNPNTTDYLMGLFGERHTPYVVDRDPAPAGTPRLKEMVQTALRILKKSSQGFFLLVEGGMIDRSLHDTHARRAVEEVVELDETMQAALDMVDLEDTLVLVTADHSHTLTMAGYPPRGNDILGKCHLAFPGQASRRLNFVTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVH9</accession>
    <name>A0A8J5MVH9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G004947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVH9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7164569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="378" mass="42964" checksum="9839AB3EC695A5BD" modified="2022-05-25" version="1">MDEDKFADNTNKKYWSGRMLFPQQQTLDIKHWMSVTNPRFDHNSLHAGRQQHQQQQQQQQQQQQNECGDSWMFKDGLLIMEMGYLLGYLFNSVFLVVFMMAIMMIARSVIKEAPSLLTASNSSSISSSSSSSSRIECGDSWTFKDGLLIMVTITNSVFLVVFMMVIMISVIKRRSITVNSIRQDSLPDNDTLASSETPPPSYFELEIDDQNCCDYNSSITSTLMTPSPATHLLFKIKSWFQKFGHSLECETMKISLLIIPQEILELEDALPPTTNVQQQQQQQNECGGSWTFRDGYIIMVIGYLFNSVVLVLLVITAIMVIRRVIKKRSITVNSIRQDSLPDNDTLASSETPPPSYFELEIDDQNCCHDPTPSYPLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWP3</accession>
    <name>A0A8J5MWP3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022960">
        <property type="protein sequence ID" value="KAG7166072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWP3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="213" mass="23585" checksum="D46F78443B770D7B" modified="2022-05-25" version="1" fragment="single">RWVRKVVLGEEGVVVDEECVVVDEEGVALGEEGVALGEEGVVLREDGVGVNEEGVVLREEGVVLREEGVEVGEEGVVLGEEGVVVDEECEVVDEEGVALGEEGGEVDEEGKRENNSHIDCGCPREKKIPDLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDSSSDEQEATSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWT0</accession>
    <name>A0A8J5MWT0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cell division cycle-associated protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G005636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022531">
        <property type="protein sequence ID" value="KAG7166521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWT0"/>
    <dbReference type="OrthoDB" id="6337960at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038832">
        <property type="entry name" value="CDCA3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34756">
        <property type="entry name" value="CELL DIVISION CYCLE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34756:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="245" mass="27052" checksum="035BA700CF132898" modified="2022-05-25" version="1">MGGLASKHMEDIFKAPGTPQNTHVLPGDPRSPSDYISRTPIAVTNTPDSSNDGTPRLKVLASDPRSPNTDVNRTPIVVETNTERRRPFHLKPSRLEQLESVSSTSNGSNDTENDPRSPTTKVPRTPLDEKEHVFDTEPITQNDSENSADQYSTEVEEAAASENMDDQEKSLVKKLFPCGGSTDKMRRPLTSVQNTASNNTPRGRLQAKQCKNVEEEYNKSQKVILDQLSQENTVVASSTQFVESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXT5</accession>
    <name>A0A8J5MXT5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc transporter ZIP13-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Zip99C-L2</name>
        <name evidence="2" type="ORF">Hamer_G012807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXT5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="77" mass="8475" checksum="8992141DBE3602E3" modified="2022-05-25" version="1" fragment="single">MQNSSPEWLESAMGSSVVVWPPWPTEWLQGNHMDTLTVLATEYQPWICSIIAALAVGLAGIVPLLLIPTDHEMKTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYQ1</accession>
    <name>A0A8J5MYQ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative extensin-2-like 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016845">
        <property type="protein sequence ID" value="KAG7169400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYQ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="201" mass="22765" checksum="9AA34188BD6DB236" modified="2022-05-25" version="1">MLAYSGAESYLILKQNPIQFWDGILPNSEAESYCLLGRILTAFSGEIQPSLGTKSYCRLGRFLPSSRAESYHILTQNPTVFWGRILPYSGAEFYRLLGQNSTVFWGRILPYSGAEFYRILERNPTVLRAESDRFLGHNLTVFGDRILPYAGAEPDRFMERYPTVSLGKTLPYSGAESYPILGRIPCVSWGRNLPYSGNRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZL0</accession>
    <name>A0A8J5MZL0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G027305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016633">
        <property type="protein sequence ID" value="KAG7169429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZL0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7169429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="422" mass="47440" checksum="E2A282A652BC5FEC" modified="2022-05-25" version="1">MGLEIKADTPPSAQICSNTSPVEESLCTTMASVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERREGAEIPPPFFLIRLDNPLIILVSSNHPSEHETIIIILSTIIIIIIIILSIIIIIIISIIIILSIIIIIIISIIIILSIIIIIIILSIIIIIVIIIIIIPTAAIIDLPLCRQLVTSLRLFNPQKTDAGNNHGQTLTRTKTRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZV1</accession>
    <name>A0A8J5MZV1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G012343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZV1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7170108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="425" mass="47825" checksum="29626E1E014A9E07" modified="2022-05-25" version="1">MHECRSEVGDVHPSHEWWSCSSSGYHSGVGTSEVSVKERAALNASLTTDYASDDDSDWGEDEWPVERPLPLPEWGCGRPEVNFSTLHHYQRFLARLTHHLHHALADLPYDTLSNFITFSKEFVESRDEYPELLEFYRDYDPPLLPGRYTCVGLAADLATRLSVLETNYPGLKDATYQVSCEEEVKALDWYCSLKEPPVASCIKEHVLLCIRIRVAGRAGVLLFDPGYHVGEPITVMEDGLAPQSGIIKASTTRSEVHRTFQYHFCADNPAFVAWEVVEERDGKPKKKFTSLIHVSRPFLSGVDIAERRNLVETFKTLLGRDDEGHLTCGLYFPIRNCYNTNISFFHQVEGIMKHLRQPLSSFLDDALLEEVEEAVAAVAAGIGRTKNDLQSSLVTLAHLLLDEDLVKQVMELNSAIIKINSSLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0B7</accession>
    <name>A0A8J5N0B7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LSM12 B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lsm12b-L</name>
        <name evidence="2" type="ORF">Hamer_G013413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0B7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01735">
        <property type="entry name" value="LSm12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048478">
        <property type="entry name" value="LSM12_LSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21166">
        <property type="entry name" value="LSM12_LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="83"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="205" mass="22369" checksum="787E2CFBF4624FC9" modified="2022-05-25" version="1" fragment="single">RSKMAESNECFNIGSTVSCLTCFDEELQGEVVAFDPHVKLLTLKAAASSGRASLCDIRMVNLSYVSQVNVLREAAGSPLPSLPSLNLAKLNSRAKRSIEEKQRLIQAMQSGVSPEGQKLFIAICKTIEEVTWAGANILVMGQVLISPPYLPENVREHKEGKETNTKTLSYIRKIVDKFHKDQQSLSLNNGTSAAPVVAEVQPVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N104</accession>
    <name>A0A8J5N104_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dyslexia-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G013800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012455">
        <property type="protein sequence ID" value="KAG7171335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N104"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="95" mass="10233" checksum="1C2BB16A13D7C658" modified="2022-05-25" version="1" fragment="single">PHHLDEVEVVVGGDIGSMSYSQLSTLLQKLELFLHTGDSVVAIHLISLTGLPHSAWSTKPTTTERGNKCCYWKLAPQDLLAVTATTGSHRPATVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N117</accession>
    <name>A0A8J5N117_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G013553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N117"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7170722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="109" mass="12316" checksum="8B362EF079D961B3" modified="2022-05-25" version="1">MKDTIAPNISEEARLGHITCNIWGWVTLHGLGDVFIIEGRFTEAKCIQLLEERSLSSLRARNFPFPAGPVLFIHDRSSIRTARVVHHWLQEQDPSALGMAQQMSGHECH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N146</accession>
    <name>A0A8J5N146_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G012503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N146"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035256772" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="857"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7170932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="931" mass="102107" checksum="09884667E3C61EED" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1K6</accession>
    <name>A0A8J5N1K6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1K6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035273038" evidence="1">
        <location>
            <begin position="16"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="172" mass="18899" checksum="280044C671F4E89A" modified="2022-05-25" version="1">MRTLIVVLLAAFVAAEQKREAEPSYGLTNYGHGYRYGHGHSYGYRPVASYHPYGLHSASHSYNHILHKRDAEPSYGLGYGYGHGLGYGHGYGYGHGIAHHPYHGHSYVHSHGIGKRAAEPSNIYGYPGYGYGHGLVHGHGAVYGYNTGVHHPGYGHSYQHRSGVVLPSYGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N213</accession>
    <name>A0A8J5N213_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-fold modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Ufm1-L</name>
        <name evidence="5" type="ORF">Hamer_G025206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011720">
        <property type="protein sequence ID" value="KAG7171741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N213"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005375">
        <property type="entry name" value="UFM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825:SF0">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03671">
        <property type="entry name" value="Ufm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7171741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="324" mass="36181" checksum="2D62F79ABD4405F3" modified="2022-05-25" version="1" fragment="single">MTSKVTFKITLTSDPKLPYKVMELALSQLAKQSPWVLTVHDLKNARQLLLRLLVQNQLLKPDVKEHVHYVVYKVLGSDEAAILHKQASQQQKFFKKLNNTLRQNKDLKRRLQTRLMLEAANSSGQGELQDCLSKMVVLPRGLSQILEAAKLDNAAGSINQNICLGPQIINWFEGVLLSPLDNNHRRLEMVCHWCSQDGGAAWIDVLKDANVKKQQDEQQHNDQPGKNTPFTAVLKFAAEEFKVPPATSAIITDDGIGINPSQNAGSVFLKHGSELRLIPRDRLICETCKTGILRLKIYPSSTQYSTAVPSFPHAHSVNGMPLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2F8</accession>
    <name>A0A8J5N2F8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine--tRNA ligase-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Cars-L1</name>
        <name evidence="5" type="ORF">Hamer_G000865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2F8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="4">
        <location>
            <begin position="45"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7171923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="334" mass="37420" checksum="55696AD5501629FB" modified="2022-05-25" version="1" fragment="single">LKHLESCLNVLIQGGLFPKVLNPQDCTCITRSHVKRNCFYLKVMSSYVSFDILRRVMQDYFGFVIHYVPRDQVYDDIAAAMEHHNAIIATTTDPDKCKMLIDEVQKVKIAAEALKTVTNSSNAAEASVKQEELLASASSVLGEWLDKQKGRDITDNSIFAELPRHYEEEFNKDMEALNVLPADVITRVSEYVPQIVEYVEKIIANGYAYESNGSVYFDVGKFDAEPNHYYAKLVPEAYGNQEALEEGEGALSLNTAQEKRSPNDFALWKASKPGEPAWPSPWGPGRPGWHIECSAMASDVLGESLDIHTGGVDLKFPHHDNELAQAEAHYNNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2W0</accession>
    <name>A0A8J5N2W0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Ulp1 protease family, C-terminal catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Hamer_G009536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2W0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34718">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34718:SF2">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="250"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7172193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="440" mass="50096" checksum="26D9881D9C415CDE" modified="2022-05-25" version="1">MQSSKNVEAAQEKQKVQYRNRKIKAVKMYNINVGMLVLRRNLRNESRKGGKMEPKWSGPYKVLDIDSYQRVALELVKDSKKLKARVPYRHLRPLQSRFLNKASLMKSDTLISDHETPLQSRPVSPCDLLNDTPDVQLSTNPTPPSSPTWRPDEWNDMVVDRSTGQIEECVVARGKLQPDVHLAPVHKDPWVAASEVGCPGNWLSDAHVDHAQHLLGSSFPFISGFQSTVIFYCKNCVQVQAPVNHFVQILSVHKNHWLTLSNIGCNNNTVRVFDSLSSSGLQNSEEFNCQVAALLNCKSPKIRVEYANIKQQKGYSDCGLFAIACATSLCFGLPPETQNFAQEHMRSHLAKCFRDGIMKQFPVKSPTMTLKKNTYRYYEISIYCHCRKPKLVDSFLIQCMLCNNCYHIECENVMKDMKLFVCTTCKNFITEVLVSCNYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4S0</accession>
    <name>A0A8J5N4S0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009960">
        <property type="protein sequence ID" value="KAG7173422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4S0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="81" mass="9070" checksum="D8FAAB3239A73178" modified="2022-05-25" version="1">MSKALSARLYDIDPSLDRSLKAKRAIENVMLPYIELQGEMRSKKAQTTITNFFSRRVPVIAEPADTSQQQQDVEAAGTSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4V4</accession>
    <name>A0A8J5N4V4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear receptor subfamily 2 group B member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RXR-L</name>
        <name evidence="15" type="ORF">Hamer_G018639</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family. NR2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009960">
        <property type="protein sequence ID" value="KAG7173360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4V4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06956">
        <property type="entry name" value="NR_DBD_RXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06943">
        <property type="entry name" value="NR_LBD_RXR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000005">
        <property type="entry name" value="Retinoic acid receptor RXR-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000052">
        <property type="entry name" value="Ultraspiracle nuclear receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000003">
        <property type="entry name" value="Retinoid-X_rcpt/HNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00545">
        <property type="entry name" value="RETINOIDXR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="79"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="175"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7173360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="405" mass="44449" checksum="5FBD20648D7700B6" modified="2022-05-25" version="1">MSGSLDRQSPLNVTSDTASLLSPSSSSFSSANGGPASPSIPTAPFTIGSSGNMLSSSNSNSLSTSPNQYPPSHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACREDRSCTIDKRQRNRCQFCRYQKCLSMGMKREAVQEERQRTKGDKGDGDTESSCGGISDMPITSIREAELSVEHTDEQPLDQGDAVTNICQAADRHLVQLVEWAKHIPHFTDLPVEDQVVLLKAGWNELLIASFSHRSMGVEDGIVLATGLVVHRSSAHQAGVGTIFDRVLSELVAKMKEMKMDKTELGCLRSIVLYNPDAKGLTCCNDVEILREKVYAALEEYTRTSYPEEPGRFAKLLLRLPALRSIGLKCLEYLFLFKLIGDTPLDNYLMKMLVDNPNNTSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N540</accession>
    <name>A0A8J5N540_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WSC domain-containing protein 1-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Wscd1-L9</name>
        <name evidence="4" type="ORF">Hamer_G024330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WSCD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009364">
        <property type="protein sequence ID" value="KAG7173601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N540"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="154"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7173601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="323" mass="37184" checksum="B016920D4A6F130A" modified="2022-05-25" version="1">MSTRRFRTNQQLPVIMVALISMISIYCVFSSFTSTSFQSDTADDTRLKEIRKSLHGRVVRNNGVVTGRFGWNLVRVWLVSFPSSGNTWTRYLLEASTGIFTGSVFNDKTLFNAGFLGEKEPPDSGRTIVQKTHGGSLSGNPKEDLLDRYLLINSTLPAILLLRHPAKSFISYWKLLRTRNAKDKHTGQLSEKMFETNSFHRYVEQVTRLWEQLAVDTLLWSVGPLHVVHYEDLVADTDHHLRQLLYFLRVPMDEDRLSCVRSHLTGNFKRVGNKELDPFTTREKIKMTLAIQRVNRLLLVLGYPEFPYIDNIFHNTTQFNGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5Q4</accession>
    <name>A0A8J5N5Q4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009396">
        <property type="protein sequence ID" value="KAG7173569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5Q4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="357" mass="40395" checksum="2D4CAF484CF80E29" modified="2022-05-25" version="1">MDRTNLSDRNAVFVAGAVTQALGHDIADMSFSRSTIRRYRASGRKQAAETDRKSFSPDEPLLLHWDGKLLPDVQNTTASRIAIVVTFNGQEKLLGVPKKERETGEAQAEACLEAIKSWNVEKLVKGLVFDTTASNTGLHRGACVRIEDELEQELVWIACRHHVLVIMLSDVFSLICGSTGSPETILFKRFKKQWRSISLNDFIPAPESMIDTETKKNMVQNFQCPKKQDFSRRIVLSDETPISNVASFVTERTLDIFDILTLDGKERAQLFLSKDPKTWKDDEVFITMRDRAINMKVVNDSAERAIALIERYRPGAVRPAVPLRTLQLITEKLPTANQSTMMKDTNKECVLIRVIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N619</accession>
    <name>A0A8J5N619_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N619"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="111" mass="12468" checksum="FF3815D27ACBA2C9" modified="2022-05-25" version="1">MEGKCHKRPRKENNIFDIDNMSPAIHPVAESPTFAIPTVMKYKIPEETEFNHAYEVVVALELEHKNIKFSVKPNLVGDPILSPQDHNTAKILSEVTNLNGKTVKIIPLAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6L8</accession>
    <name>A0A8J5N6L8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemocytin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Hmct-L</name>
        <name evidence="7" type="ORF">Hamer_G003066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6L8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01185">
        <property type="entry name" value="CTCK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CTCK" evidence="6">
        <location>
            <begin position="141"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7174172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="253" mass="28383" checksum="701EFD08F250548C" modified="2022-05-25" version="1">MNDNQSRIEIGVTVQDPNDSCLSISCVSSAEGNITRREREITCDVLCDRGSSYSQPVSDECCGKCIPTHCVDDDVAYSIGQHWESEENVCFEYSCELRNGVPTTVATRKECPYFDPECPDEAIYMDEFGCCKGCNTTTGKCKPEVIPLEETVGLFEISLPRRGTCRNTNTVPNFKRCSGSCDSFTVFQKQGQQQKHVSTCFCCKPSKSDKMEVELLCDTGETYISHYDNIVECQCLECSDNPQEYEPSKRIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6N4</accession>
    <name>A0A8J5N6N4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Centrosomal protein of 290 kDa-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Cep290-L1</name>
        <name evidence="10" type="ORF">Hamer_G017810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007950">
        <property type="protein sequence ID" value="KAG7174085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026201">
        <property type="entry name" value="Cep290"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18879">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 290 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18879:SF20">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 290 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="534"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1778"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="124"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="384"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="474"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="792"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="873"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="959"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1137"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1241"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1417"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1601"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1849"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1966"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1781"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1811"/>
            <end position="1826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
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</entry>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044077">
        <property type="protein sequence ID" value="KAG7154739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010023389">
        <property type="protein sequence ID" value="KAG7165827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010003198">
        <property type="protein sequence ID" value="KAG7176503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010001941">
        <property type="protein sequence ID" value="KAG7177511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NC45"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="68"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7154739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7165827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7176503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7177511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="245" mass="26782" checksum="65611EB49141F77E" modified="2022-05-25" version="1">MDKNHIVDNKGQEAQVSLVRVTTIPRKTSSTPTSSSIPHTSSSSHTSSSSTTSSSGGRDLPQLTWDHLSLMGKVGTGRYGVSHHGQLTLDNGDVTEVVVKILHSGKDNTKEARVLHELAGTGGAPILYGVTTDPHAIVMQYCRGVTLSTILHHFRYQVHHRQEAYDATCVALAEFHGAGYSHLDLHAGNVIIDTSTSPYTCHLIDVGMSERIPPDDDWYEQTDWVALQDIQTRLHLHSPDDLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7178071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="9748" checksum="F3AB3FA0144C93D0" modified="2022-05-25" version="1">MIDALAFLPLEDVDEGMKYLKTVTPQDPPEAEELLRYFDRTYVSGSFQQPVAMPSDALMTLRMRHTSHMFAPHLTYVRPTPMECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCR9</accession>
    <name>A0A8J5NCR9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCR9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="128" mass="13836" checksum="ECDCA0B307B7004A" modified="2022-05-25" version="1">MQEAAYQKAKSSTYNDIDTSPGTDAATPFIAMANRFYSLPVEGREGLQWGWAFLSCPRVERGVCGFVATDNPDVDPSGGPTPELTPGDGSPYGGSIEVTPMPGVPAASHYFSWGLITRYFQKSISWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ND31</accession>
    <name>A0A8J5ND31_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G008236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ND31"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="73" mass="8304" checksum="5A6CF0CA6368C624" modified="2022-05-25" version="1">MITWERQAKWRQSSTLIGQVAPKDLSWSLIGRRQAALPDLRRISKHTNTMGNSLVLGVTTPYQHSGIQQSMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T4T3</accession>
    <name>A0A8J5T4T3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative multiple epidermal growth factor-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Megf-L2</name>
        <name evidence="2" type="ORF">Hamer_G006815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T4T3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="299" mass="34320" checksum="53E667E78878181B" modified="2022-05-25" version="1">MNRTHVCEYQQEERVKVQMPTVHAFTATVRVYRPGCYTNAPACVNYERRGKDSEQGKTDDTDDGGCSVRTKTSTNSTGQITQDGEIYYLVDNSQDNNANRSDGEGSKKQLLDAPESDEEDKVSTVQSDHSHRGKNHNKDVNREKGISEYTNDEPSIRDVAEGGKSSPSVFRRESEVNTHQRPSSLTANRRRWNEHHHTQSSLTDTTTPSTRRAHRRRHRGRSPSSRDEDVTVETTYTSGRNGYRHRYNNNETKFDAYSYTIIMTDGKKNGRRREEETKKEQVSRREENIDAYLGKSYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5THH3</accession>
    <name>A0A8J5THH3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative plasmolipin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Hamer_G021913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006858">
        <property type="protein sequence ID" value="KAG7174811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5THH3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF97">
        <property type="entry name" value="RE01453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7174811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="164" mass="18400" checksum="BEC96DC10E33F4B0" modified="2022-05-25" version="1">MACAAPAWTKGTHWFLFVVVTAFVSTSIWCFVYLLNLRNAINLPIDWLLTELILTALFAVLYIIASIVQLTSTVTKPRPPRRLKPFYLLSGELFNTAITTLLYLIAVIVQFCSIELATQRNIAAGVFGVFNMLTYAIGSFYLYRDWKDSHPHSSFSGSVLKGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5THW1</accession>
    <name>A0A8J5THW1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase PPP1R11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein phosphatase 1 regulatory subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ppp1r11-L</name>
        <name evidence="4" type="ORF">Hamer_G015215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7175006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5THW1"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7175006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="117" mass="12682" checksum="092F94A780A2D928" modified="2022-05-25" version="1">MATSIPSAVSGSSSTVVESETPHLGAEEQVSSGVVRLKLHKPRTKKVSWTNDTIDNENMGKKKSKCCCVYVKPHEINDSSSDSDDECQHCSGHVEKKKKNQPQSEESHGNEDPSGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TK24</accession>
    <name>A0A8J5TK24_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cellular tumor antigen p53-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Tp53-L1</name>
        <name evidence="7" type="ORF">Hamer_G015348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TK24"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011615">
        <property type="entry name" value="p53_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312:SF1">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312">
        <property type="entry name" value="CREB/ATF BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00870">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="p53 DNA-binding" evidence="6">
        <location>
            <begin position="316"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="484"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7176551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="568" mass="62660" checksum="5B3D770DFD5AE820" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TK37</accession>
    <name>A0A8J5TK37_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Potassium channel subfamily K member 16-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Kcnk16-L</name>
        <name evidence="15" type="ORF">Hamer_G015365</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TK37"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF142">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="117"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="221"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7176566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="386" mass="43260" checksum="162C0B1C5083A93D" modified="2022-05-25" version="1">MKENERLRKAAGHVSFFLVLVLYTSLGAKVFQVLEYKVEMRNQEQVWTHLQEKRQQLIEQVLNLTSLQQQQEDDGVQMVTDEPGTEELVWQWLREYEVVMEESEGAGVSPLDTQIHTRWAYTQALFFSATVLTTIGYGNIAPSTVEGRVFCMVYALVGIPLTLSVIADLGDVLASFIPANTFENRLPKYVNSLFLSIGLTENVPLRGKLRAVTTVLLILTLLVGFIALGGVLFMWQNNWTFMEGFYFSFITTTTIGFGDLVPATSTLCMLYIILGLALTSMVIELVRRKYASSWAQMKQLSSRLHTLSGPLAEAMRKLAESGAGEVEMDEELVRELRDLNVALAKVQQEETGTETVTTGNEDAWAALLDMAAKKKRITVVMYESNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TM80</accession>
    <name>A0A8J5TM80_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Transposable element Tc1 transposase-like 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tc1a-L20</name>
        <name evidence="3" type="ORF">Hamer_G001303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TM80"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="64"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="137" mass="15710" checksum="75B54D1A4357FBE4" modified="2022-05-25" version="1">MDTTQQSLTTRDQIIARREEGLTVRAITDQLAVSTSTVKRCIRRYAETERRPRPQLTTQGEYAAIRAAIRNNPFSNPVAIREALHLVSAQTVRSRLHEAGIQHRVPAIKERLTDQHRTGSRQFASNMWGRTWSFGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TMY8</accession>
    <name>A0A8J5TMY8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative AMN1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Amn1-L2</name>
        <name evidence="1" type="ORF">Hamer_G027734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005595">
        <property type="protein sequence ID" value="KAG7175548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TMY8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="87" mass="9002" checksum="C1004457293FE859" modified="2022-05-25" version="1">MPEPPVVENNNFSENSLMGLGEGKSMLRVVALNGLCGVTDGVIGSLVGGCPQLQEVHISSTSITNHALTALANLTQLVCLNIGKTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J6Q2</accession>
    <name>A0A8J5J6Q2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045856">
        <property type="protein sequence ID" value="KAG7153987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J6Q2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="88" mass="9775" checksum="205037D5CF498D74" modified="2022-05-25" version="1">MIDTKRITTYKELALTVLSTIVKGVEVSSLIDWVVDTYSDTSIRFTGNQNSFRDSKSRLFVQKVLLQSSVQTGTGRIACKNIAETNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J8T6</accession>
    <name>A0A8J5J8T6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Facilitated trehalose transporter Tret1-2-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Tret1-2-L6</name>
        <name evidence="11" type="ORF">Hamer_G020392</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045270">
        <property type="protein sequence ID" value="KAG7154095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J8T6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7154095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="437" mass="47204" checksum="F11F06006C769CE3" modified="2022-05-25" version="1">MGALAMGTVLGYSSPAGVKLMSNSTTGSLHLTKEQNMWFSSSMNLGALVGGPVGGVCLNTLGRRGTIMALVAPFSLGWLLIALARNFAMLISGRIVTGLCAGMTSLVVPTYIGEYASADVRGTLGSAFQLMVTIGVVYSYALGALVSTWQLLAGLCIIPSILCCVLMLFTKESPSFLLSKGKEEQATAALQFFRGKDCNIQTELDMMRQSMEEAKHNKTSLKDFMKPYILKPLMISLTLMFFQQFSGVNPVLFNLTTIFSVAATFLATVLMDKAGRKLLLIVSSSLMALSIVALGEFFYEKMEDESWAIKKLSWLPLVSLIIFISAFSIGYGPIPWLMIGELFPSNVKEAAGSFSTMVNWSLSFVVTLSFVPLQSVLGVHGVYWLYGSICVVNLLFCVTLVPETKGKTLDEITAYFGGPFSSGGSQRAGTNEFQVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JA61</accession>
    <name>A0A8J5JA61_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043017">
        <property type="protein sequence ID" value="KAG7155142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JA61"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="119" mass="13836" checksum="3CB8028B428E01AF" modified="2022-05-25" version="1">MTVQVFWKKFNIREAVNYLVSAWNQITNAPVHHAWMPLLPHLAKSQDSRQQQEDLLLETVQSVQSIPAPGFNSVNEDQINELLGALRICWENKIRFSKKRPHKLCNNRRSQQLVICLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JAC8</accession>
    <name>A0A8J5JAC8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 91-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Znf91-L2</name>
        <name evidence="10" type="ORF">Hamer_G014969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF235">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="470"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="499"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="578"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="691"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="852"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="920"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="974"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1033"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1061"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1087"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1115"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1173"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1201"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1266"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="128"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1512"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1574"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1518"/>
            <end position="1528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7154620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1603" mass="182002" checksum="3DE77F4DC8351F4B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JBM9</accession>
    <name>A0A8J5JBM9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Wnt4-L</name>
        <name evidence="11" type="ORF">Hamer_G020996</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Wnt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043055">
        <property type="protein sequence ID" value="KAG7155130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JBM9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF101">
        <property type="entry name" value="PROTEIN WNT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7155130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="157" mass="17997" checksum="C5601EAF26329C1A" modified="2022-05-25" version="1">MTLIEMHMRIECKCHGVSGSCELKTCWKAMPTFREIGEILKDKFDGATEVRVKEVSGRSELEPNKQYFKKPTEVDLVYVSSSPEYCDYDINSGSLGTHGRRCNKTSRGLEGCDLLCCNRGYTSYQESVQERCSCKFHWCCFVRCRTCTRDVTVHTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JBT5</accession>
    <name>A0A8J5JBT5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tramtrack-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ttk-L3</name>
        <name evidence="4" type="ORF">Hamer_G017532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044465">
        <property type="protein sequence ID" value="KAG7154334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JBT5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF109">
        <property type="entry name" value="FI07618P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="35"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7154334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="364" mass="39738" checksum="9B519A596A457F64" modified="2022-05-25" version="1" fragment="single">MASKMDGELLSLKWNNHRTTFYHVISGLRNKETYTDVTLACEGKFYPVHKLVLSTCSEYFSDIFDRTPCKNPVIVLKDIQCQDLEFLLDYMYIGEVNVRQNELSSLIKAAECLRIKGLAVPDEEPKKSGTSSANTSGVSQSRQRPEQTSPPAKRRRAEERRVTPAGTEHSPGRPPGDGPGSPDHRELNVGRQPGVSEASNPREQPEEAQTDISAADQPPVHIKVEHQENFEQSANDDFLSVQSNSYDGGGGEEGDGPHSSEGNTNDFPEFLQSTIEKEEPVAMSDFNPSDFPGPSGLQNSGMAPWESENNSASFAEGLSGAVAAAVAAASQPQQQRQQQQLVSVHLSLCFEGAITKGVKLSYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDV5</accession>
    <name>A0A8J5JDV5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G021203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043652">
        <property type="protein sequence ID" value="KAG7154871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDV5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="333" mass="38870" checksum="50B4796B7DC08239" modified="2022-05-25" version="1">MNEDNRYRRHSFHSTETYSKPRLFSSFKNSSVIHDNEDQKENTQRKRLLSDSAIIQFTKARSFPREAPWGSEQKIVTPAYHELPIQSGRWKYEECEGVKGVSEQPLDQSPPVVLRRRTCSAIEKRRSPDQRFSETQLVKSVFARHRIIPATFANYRYTNALEIVLPEVLRRIFFYKYGGPCNLTLEEYFTQNLQYSREKLKSIFGSTLRKKLNVKPTELTCNDVSLWYKLLQVGCNLAPPESMVWYEDGFDNDSLEHILWELKEMRNVRVHGETSACTLTIPEYLDRLQKLKELCQLTIKAASGETGDLDHFMEEIKKDLGQYELDIASLPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JES6</accession>
    <name>A0A8J5JES6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044610">
        <property type="protein sequence ID" value="KAG7154300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JES6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035213417" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8280" checksum="FC62FD94B316F6CE" modified="2022-05-25" version="1">MRCGAGHSSRLTVLVDLFTLCGCGEFAGPTPDCMCGVPLDLSGTLFTAHCRQESKVGSLYAAAGRMCRRKQVRRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFL2</accession>
    <name>A0A8J5JFL2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pancreatic triacylglycerol lipase-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Pnlip-L5</name>
        <name evidence="8" type="ORF">Hamer_G015030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFL2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000033">
        <property type="entry name" value="Pancreatic triacylglycerol lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002331">
        <property type="entry name" value="Lipase_panc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00823">
        <property type="entry name" value="PANCLIPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="7">
        <location>
            <begin position="112"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7154675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="600" mass="65220" checksum="9D1202865FE48AF1" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JG91</accession>
    <name>A0A8J5JG91_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative winged helix-turn-helix domain containing protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038002">
        <property type="protein sequence ID" value="KAG7157110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JG91"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="96" mass="10829" checksum="8A47A9E0387E2621" modified="2022-05-25" version="1">MSRRVTKRDDMAAVIALYKSNHVPREISAQTGVALRVVKNLVKRFRDLGEDKLPAPLPKSGRPKLLSPQTLKVISRQVRSNPSLTAREVKERNPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGX0</accession>
    <name>A0A8J5JGX0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc transporter ZIP11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Slc39A11-L</name>
        <name evidence="6" type="ORF">Hamer_G020477</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045000">
        <property type="protein sequence ID" value="KAG7154168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGX0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF211">
        <property type="entry name" value="ZINC TRANSPORTER ZIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7154168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="310" mass="32625" checksum="5628000FAA80E3EA" modified="2022-05-25" version="1">MIEGASPVTQALLGTLFTWGLTAAGSAVVFLLSGTQRKVLDGSLGFAAGVMTAASFWSLLAPAIELAETSGSYGENGEWAFFPVAVGFLFGALFVYAADVFMSSIGIQSPNLILAQRDTKKTDGDNGYTRHSVYYSQQSDISEVGQGSRANAFTSIDFNLVKQRRGDGGDRMSPTDEMMKRIVKKCKMNFFSGGEYCCLSLQSLCTTSLGLAVGVGFGAIGKTPLSTFNKAKYGQLSGMVEPIAGVLGALAVSLCNPVLPYALGFAAGAMIFVVVDDIIPEAQTRDNGRLASGWCIVGFIVMMVLDVALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHL0</accession>
    <name>A0A8J5JHL0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 814-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Znf814-L</name>
        <name evidence="10" type="ORF">Hamer_G008902</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHL0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="706"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="390"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="483"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="668"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="787"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="889"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="945"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="802"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="912"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7158262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="980" mass="107211" checksum="C15DE1139B3AFC9A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JI21</accession>
    <name>A0A8J5JI21_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046868">
        <property type="protein sequence ID" value="KAG7153519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JI21"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="216" mass="24098" checksum="308CACCD1845CBB1" modified="2022-05-25" version="1" fragment="single">AGGNTTKATVRHAWSALLPQLKSAETKRQQPAELMNQVLETVCSIPAPGFQEVTREDLEEPMQEGNTNDVEDLPEDEEGGDAASDAGETEQRKVTTQKLSLLLGVCTSLQEMIQDIESESGEREQMIGFVESTSRKYPKQYNEPVNARQQSPVTRFLSQRRPAEEDQQRQAEVDEDIDDIGEMPEDFDLVGFDEVLAEVGEPVSATTQLEEICVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JI60</accession>
    <name>A0A8J5JI60_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035076">
        <property type="protein sequence ID" value="KAG7158472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JI60"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="68" mass="7723" checksum="C5E0BA8EF37D8A79" modified="2022-05-25" version="1">MRGGYCAMTDLAPRPSRPPPHAHIRTLLSTTHITYTRKCSLPPRLHEETRSVDTHKHTPVLQSHAVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JI62</accession>
    <name>A0A8J5JI62_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Fxn-L</name>
        <name evidence="13" type="ORF">Hamer_G025133</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010037353">
        <property type="protein sequence ID" value="KAG7157591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JI62"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00904">
        <property type="entry name" value="FRATAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7157591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="107" mass="11669" checksum="90540463ECBC5CD2" modified="2022-05-25" version="1" fragment="single">YEYCEYKTDSEILALGTSLSVISSPSGVLTLKLGSFGTYVINKQTPNKQIWLSSPVSGPKRYDFVDGVWVYKHSGVTLHHLLSQELSSVFKTDIDASSCAYGGKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JI67</accession>
    <name>A0A8J5JI67_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U-scoloptoxin(01)-Cw1a-like 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G024113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038351">
        <property type="protein sequence ID" value="KAG7156869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JI67"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF42">
        <property type="entry name" value="FI18455P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="71"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="191" mass="20979" checksum="3D8EC7DB4D57E175" modified="2022-05-25" version="1" fragment="single">GKVQRGTIKRCQHLQQHSANHSLSTNTMMTKCMALLTLSLLGVTYGQPVVGHRRPGRPPSSAILASVPDTGFSCEQQEFPGYFADTADEAGCQVFHICQFDGRQDSFLCPNGTIFNQQYFVCDWWFNVDCAASQQFFGLNAEIGKIPEDAAASFRSDVVAPSQQYGAPQQRQSAPAPPPTPSQFYNSPNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIV1</accession>
    <name>A0A8J5JIV1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G014910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035946">
        <property type="protein sequence ID" value="KAG7158026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIV1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="137" mass="14560" checksum="8F00D1D920F032F2" modified="2022-05-25" version="1" fragment="single">VTVRLQTGYKESRLTPNHSLVAPSPTHTHTSLLTSSYCCRLSTVRIMAGYLTCLTWVLLLALCYTPTPAHSGSFGSAGIGGGGGIHDGPWLGADEYLGGSNADSTVSGVILRTCQTSDMRVLHSTQDPKSNRHDQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ39</accession>
    <name>A0A8J5JJ39_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Foot protein 1 variant 1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Fp1-1-L1</name>
        <name evidence="2" type="ORF">Hamer_G026722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034634">
        <property type="protein sequence ID" value="KAG7158565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1745"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1745"/>
            <end position="1763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2704" mass="301652" checksum="50499A928EA6613C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKB7</accession>
    <name>A0A8J5JKB7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CBP80/20-dependent translation initiation factor-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CTIF-L1</name>
        <name evidence="2" type="ORF">Hamer_G016602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKB7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF16">
        <property type="entry name" value="CBP80_20-DEPENDENT TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="438" mass="48029" checksum="1D768EFFC1A5DABF" modified="2022-05-25" version="1" fragment="single">SGGRSGCLAGQFEPGRASSYRATSSGSANTVHLTGEQAREQSRRRSAMPATNRSKPAMELYRPPIHSPALRGPGIFDNANGDAVMNGKMAHNGGYHDKSGLNVNAREFVSVSTRPPLQHSKSSSSVPLQGRPGGLQHSKSGSNLRQTTNGDVRPPSGSPPRVHFSDDKENDPELKCVPVSRPPSLAVGILSQSGIKRSKSLGSADLRASQLLEASTPTTAMPDLGPFSPDVQNSITKAMTDPNSVSARQLMEVVRHVFTRKEKNETFLETLLNTCQEYFQERDRLLRNNPPAPYPGFVPAHPRWIAYMTFLNEMYTQLKRRHVQLMTKRMRNSETAPGLLLLTLLAQCCQVCLKENAVNSLAETECLFFVLTGVGKDIEVELPHQMARVMSAARDAFLTTVRVPAVRKTLLQLIEMHAARWQLPAPAVMYYYPGSGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKJ3</accession>
    <name>A0A8J5JKJ3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative CUB domain-containing protein-like 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Cdcp-L14</name>
        <name evidence="5" type="ORF">Hamer_G026437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033428">
        <property type="protein sequence ID" value="KAG7159330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKJ3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035191918" evidence="3">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="34"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7159330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="141" mass="15228" checksum="D37F6F42DB9F4A61" modified="2022-05-25" version="1">MMMKYMLTLLVVTVTVVGAIDNKTAPVDPVILPCVSHTMKLGDVVLVQSPGYPARLTNKSSCQQNIVCQSLSAKLGVACEVFNLEDCDNERLIISYDTTSSTLCGNVKPNGVFPTNAMKLEFITKGVNDSTGYNCSITCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKY5</accession>
    <name>A0A8J5JKY5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GTP-binding protein Rhes-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RASD2-L3</name>
        <name evidence="11" type="ORF">Hamer_G021638</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031456">
        <property type="protein sequence ID" value="KAG7160262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKY5"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000475">
        <property type="entry name" value="GTP-binding protein Rhes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF7">
        <property type="entry name" value="GTP-BINDING PROTEIN DI-RAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7160262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="288" mass="31703" checksum="856208CE9DCEF651" modified="2022-05-25" version="1">MMKGRHFARRFSLQPALYEEDRPSPVSKDEDTAVEGATAAGALAGTSSRGAGDPGAGTSNGAASSSAEKDGDNPKKRRYRVVVMGAAKVGKTAIINQFLYDSFTSKYTRTIEEMHHGEYEVSGMSLTLDILDTSGSYEFPAMRELSVNTADAFILVYSITDAESFEEIRHLREFILQTKKQNVPIVVVGNKTDLEDQRAVPLETAETIVLVNWEGGFLEASAKDNLNVLHIFKELLNQAKIRYALSPAVKRRRQSMPNVGMQITPAQLSHLHHIRQKSSGKRNSCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMQ1</accession>
    <name>A0A8J5JMQ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Beta-1-3-galactosyltransferase 5-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">B3galt5-L5</name>
        <name evidence="11" type="ORF">Hamer_G012060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMQ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF3">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7155919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="851" mass="98599" checksum="DA33433FB6C4EE73" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JN56</accession>
    <name>A0A8J5JN56_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030803">
        <property type="protein sequence ID" value="KAG7160755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JN56"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="176" mass="18963" checksum="264A931FE624D5CC" modified="2022-05-25" version="1">MRAATSPPGVPDTGVHPSALDRGRQAAAADAARPDRAAMQVLIRQALNVFIRVTPAPGSQGVGSGDSNGSVTATTSPTAATGHPRHQGHIAHGNGVAEDDQAVTVDDLLTRIKEHLQWQRQVALRRVRFEERRQREGESFDDFYVALKELADDAELCDQCLDARFVTHIKDPGPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNR3</accession>
    <name>A0A8J5JNR3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Regulator of microtubule dynamics protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein FAM82B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rmdn3-L</name>
        <name evidence="10" type="ORF">Hamer_G004213</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNR3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF16">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7159566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="434" mass="48987" checksum="7927156310D51465" modified="2022-05-25" version="1">MLTVAVAAALGAGVVVGAGTAYLLTRLNEHTRLTQQISNFDRAYGRTEFSSPRASAFRKKTVSFSSTTTSGSYKTAPEYDTDSSKANDTDYFSPDEDDDEFFDLSPEEEEGVNSYGENGKIESGQLSSLLDEEDHLYQLFKQVDQVIDGTGDEQTQAYNLLKNEENEYADNPEFLWRVAKATRNMAAIQEKLGNEKDKETLICDAFGYAAKALDLDKENAEIHKWYAILAGARGEFLGIRERVKSGTIFKKHIDRALQLKAKDSTLHHLLGRFCYEVSQLSWLEKRAATALFGEVPSSTYEEALHHFTAAEMLRPSGWKENRLFVAKCHIQLNNYSTAASWLERAAVAPIITPDFATLLKMPDFCGSFKCLYKFDRRHGITNKRVAGESADVVSVQPFKEELKQLIRDNNILKYEMYNDEIVQKEVLELQDKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQD9</accession>
    <name>A0A8J5JQD9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CDK5 and ABL1 enzyme substrate 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CABLES1-L</name>
        <name evidence="6" type="ORF">Hamer_G001589</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQD9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20556">
        <property type="entry name" value="CYCLIN_CABLES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000020">
        <property type="entry name" value="CDK5 and ABL1 enzyme substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012388">
        <property type="entry name" value="CABLES1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896">
        <property type="entry name" value="CDK5 AND ABL1 ENZYME SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896:SF0">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="5">
        <location>
            <begin position="37"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7160368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="178" mass="20960" checksum="2A69170F3486538F" modified="2022-05-25" version="1">MQYMPNMLDDPELRAGKHRKLLRFPSYMTSVMDYTKPSELKKELNDKFRSKFPHIQLTLSKLRSLKREVLKIARQECDIDLLTVAQAYVYFERLILKTIVNKQNRKLIAGACLILSAKMNDVKGETLSNLIEKTESTFRLNRRELTQWEFAALVALEFGLHLPTWQVNPHYQRLLFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQH4</accession>
    <name>A0A8J5JQH4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Lysosomal aspartic protease-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Aspp-L1</name>
        <name evidence="12" type="ORF">Hamer_G010905</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQH4"/>
    <dbReference type="SMR" id="A0A8J5JQH4"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000009">
        <property type="entry name" value="Aspartic proteinase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012848">
        <property type="entry name" value="Aspartic_peptidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07966">
        <property type="entry name" value="A1_Propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035161112" evidence="10">
        <location>
            <begin position="16"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="11">
        <location>
            <begin position="64"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="95"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="304"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7162225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="385" mass="42061" checksum="79AA9B92B1847126" modified="2022-05-25" version="1" fragment="single">MRHLIFLVIVALATAELPRIPLHKIKSVRRTLQEVDTAVTRAHRKWGNRGPMPEPLSNYMDAQYYGPISIGTPPQSFRVVFDTGSSNLWVPSKQCHYTNIACMIHNKYDARKSSTYKKNGTDFAIQYGSGSLSGYLSTDTVAVGSLAVRQQTFAEALSEPGLAFVAAKFDGILGMGFDNIAVDGVTPVFYNMVKQSLIPAPVFSFYLNRDPSSPEGGELILGGSDPNYYSGNFTYIPVDRKGYWQIKMDGIQMNGARVPFCEGGCEAIADTGTSLIAAPVEEARSINKKIGAKPIAGGEWSVDCSLIPHLPKISFVLNGQPFTLEGKDYILKVSVFGREECVSGFIGLDVPPPMGPLWILGDTFIGRFYTEFDLGNNRVGFAIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JR49</accession>
    <name>A0A8J5JR49_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger CCCH domain-containing protein 18-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ZC3H18-L</name>
        <name evidence="7" type="ORF">Hamer_G020615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033198">
        <property type="protein sequence ID" value="KAG7159388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JR49"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052647">
        <property type="entry name" value="Zinc_finger_CCCH-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46582">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46582:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="672"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="723"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="672"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="743"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="759"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="890"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7159388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="925" mass="102784" checksum="A3A30BEB25CA0FEE" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSF6</accession>
    <name>A0A8J5JSF6_HOMAM</name>
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        <submittedName>
            <fullName evidence="7">Neural-cadherin 2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CadN2-L2</name>
        <name evidence="7" type="ORF">Hamer_G004502</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSF6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:catenin complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000112">
        <property type="entry name" value="neural-cadherin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="97"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7163366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="286" mass="31408" checksum="13DF5EBBA43EEEEA" modified="2022-05-25" version="1" fragment="single">AQVIQVVATDHDDPHEGHNAQLVYSLEKNVIDESTGSPIFNIDTQRGLITTALCCLDREKTQQYAIQVVVTDGGGLKGTGTVVVDVEDVNDVPPRFSRPEWTLDVSERHSPDRVLATLTVVDQDVSNNFTFRVVPGSGHGWQMFRVEGRRVGGPGGDLRPVGPLDYENPDHRRGFRFRVEVTDAGEDGWEDKYHVDGAWVNLRLVDENDNTPTYVSDHAHLTLPEDTPLGTVLTTFTAHDLDGFRVDRAGAVRLVGSLDRETTAAHTVVVWAVDDGVPPRTATAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSG5</accession>
    <name>A0A8J5JSG5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trypsin-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Tryp-L1</name>
        <name evidence="7" type="ORF">Hamer_G004479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSG5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="260"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7163347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="487" mass="53817" checksum="C80B608A1200BCF9" modified="2022-05-25" version="1">MEISRRVCAVRMTFHKFLLARYEDGVCIRDTLTILGTSINDPVTPVCGNMTSWITTFAVKERTRLTLAMVLQGIPAYTFSIGLTQLACDNIPPFQSPTYAGIRNAEAEKYIPTTTTTEAPTTTEDPTTVENPTTVEGPTTVDPTTATDTTEETTTVMNVVRGTSSEVTTSESVVTTTESVVTTTESVPTTLMPGKLPMPPNDEVLIRAALPELESEEEEGVYTGSIGTTPAISAFRRTFELLKVNEKCWQYYDEPPTFRVIGGFYANLNEYPWQVALVYKNKFFCGGSLISDRHILTASHCVFGSFSRGLDKLRVSLGDHDLATRNETKNIVSKVKTIHWHLHYNPHSTVNDIAVIELENPVDFSYSVSAVKLPTDLTERYEKANATITGWGRYTSKSKTTSTIMKEHTAPLVNTTLCVQAWNKFPGINASYINHVCLNVTMGTPCHIGVVSFGFPLCTNVGLPAVFTRVTHYKSWIDMNLAPLNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JT90</accession>
    <name>A0A8J5JT90_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sarcoplasmic reticulum histidine-rich calcium-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G011460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JT90"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035306300" evidence="2">
        <location>
            <begin position="22"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="275" mass="30744" checksum="8316D6EAD6233FCE" modified="2022-05-25" version="1" fragment="single">QGRAVLLLLLFSAAAAETVRATTKGQLEKKDLNVDLHLQDPVEANLPLQEPVEADLLLHLQPAQSYGHDKGHKGYGGGKGHKGHKGYKGSYHDKAGYKGHKGYKANKGHKGSHYGDHGKAQYKGQKDVHHKEEYHHTKKFYDDGDKKKYYGKHDSFDSYFDAHKGKDFKGGHYKGGSHHDKHGKKGHHEKGKYHDDHKGHKGLYGDKGHYGHKSSYGKKGGHKGDYGHDDHKGYGHDDHKGHDDHKGYGHDDHKGYGHDDHKGYGHDDHGHGDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTB2</accession>
    <name>A0A8J5JTB2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium voltage-gated channel protein Shaw-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Shaw-L2</name>
        <name evidence="16" type="ORF">Hamer_G021307</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Shaw sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031136">
        <property type="protein sequence ID" value="KAG7160649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTB2"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18416">
        <property type="entry name" value="BTB_Shaw-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000020">
        <property type="entry name" value="Potassium voltage-gated channel protein Shaw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000047">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF252">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="15">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7160649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="672" mass="74936" checksum="F4F6A9B67B2EA542" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTD6</accession>
    <name>A0A8J5JTD6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G020822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026066">
        <property type="protein sequence ID" value="KAG7163906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTD6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="530" mass="59794" checksum="B5A516F2BBBDA394" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTQ1</accession>
    <name>A0A8J5JTQ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Clec-L9</name>
        <name evidence="4" type="ORF">Hamer_G014205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTQ1"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21407">
        <property type="entry name" value="RE43931P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035258364" evidence="2">
        <location>
            <begin position="16"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="119"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7161635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="255" mass="28546" checksum="155A06F1F854447D" modified="2022-05-25" version="1">MKAIILFVLTTAIWAEELYVKNEGTPVIFGVGSDGDHIMVRSPGVLRSTSSSSQSPSNQTPQGRRLGQVFPSGQPSPGQRLGQFLSSQSKPTRFLSQQTTLPQNRLCDHARRPIVDEVFQGRAYHFSWCHDGGRSYTWYDASHHCQRLGNGFQAISIEHPNEDNFVAGVLRTYQMRHIWTSGSKLGSYQWYWETGVSTGYTNWSNTGRLGRSQPDNADGNEQCLAVVNSLGVGWHDSRCGTLRPVICETEAFYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTY2</accession>
    <name>A0A8J5JTY2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent RNA helicase DDX42-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ddx42-L2</name>
        <name evidence="2" type="ORF">Hamer_G029099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030572">
        <property type="protein sequence ID" value="KAG7161009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTY2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="241" mass="25349" checksum="DD7A82E1B6DB93DF" modified="2022-05-25" version="1">MSAGSVLIFVTKKANAEELSKNLVTKEFEALLLHGDMSQFERNEVITAFKKKDKPILVATDVAARGRAGEKGTAYTLVTDKDKEFAGHLVRNLEGAAQEVPSELLELALQSSWFRKSRFKQGKAKALGGRGLGFRERPGLGCTPISESTAGSGGGCVGGGGVGGVGASMAVGPASQAYGGGDPSMTGPATNRLAAMKAAFHSQYKNQFTAASADTSWTLGDAKAVQLAPPRDRKRKSRWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV73</accession>
    <name>A0A8J5JV73_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trithorax group protein osa-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">osa-L1</name>
        <name evidence="7" type="ORF">Hamer_G005130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035060">
        <property type="term" value="C:brahma complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16865">
        <property type="entry name" value="ARID_ARID1A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021906">
        <property type="entry name" value="BAF250/Osa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033388">
        <property type="entry name" value="BAF250_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656">
        <property type="entry name" value="BRG-1 ASSOCIATED FACTOR 250 BAF250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656:SF5">
        <property type="entry name" value="TRITHORAX GROUP PROTEIN OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12031">
        <property type="entry name" value="BAF250_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="833"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1231"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="718"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="263"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="843"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1234"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1247"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1266"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7164727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1292" mass="142205" checksum="39964D9950EF77CF" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVC9</accession>
    <name>A0A8J5JVC9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G019641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024921">
        <property type="protein sequence ID" value="KAG7164805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVC9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23039" checksum="5AFE22430FC3D294" modified="2022-05-25" version="1" fragment="single">MRRSECQVTSPGYPGMYPAHARCRYLLVMSSPDTSGNITFLTMDLHPHSGPHLPPYKYSGFHATIDFSGVVGLPQPPSLTTTHPNPHTLRHTGGEQCDQVFWSNQTREGIFDTSAICPGGQHCCLRFLGQQHDVIQVSLFKYKLGGRSCSSEASIYDGLRGDGGDNLLRKLCGPLSREPRDSSGRFVQQEFFLSSGNTMEMTLYLGHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW82</accession>
    <name>A0A8J5JW82_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neural-cadherin 2-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CadN2-L4</name>
        <name evidence="3" type="ORF">Hamer_G004537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW82"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7163398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="92" mass="10381" checksum="9FA862CCFAF78285" modified="2022-05-25" version="1" fragment="single">MPTTFLLNSYVKLALSFTPLGYTTSISLRFRTWRRTGQLVVVTSQHGRDSWSVEVMGGHLCVMLRLQPRPPTSLCLSRTSLTDGRWHSLTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWN9</accession>
    <name>A0A8J5JWN9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWN9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32290" checksum="A66342B91E9B2A79" modified="2022-05-25" version="1" fragment="single">DQTLPANQEEEETVDDLTPSTTPPCNSEVLSVCEFWKKYNIKNAVDRIVEAWHKINVATVLHSWKLWFANYEISGAEQTAASGGRQSMAATLMDTVEAVRSVPAPGFSDLQVEDLQEIVGQHQQQPTIEEMLEDDEEQQEQQPTQEDDVQPGEPTTEFLTNIAHLSEQLEEYDTKPHPRNFMCSALDKGMEEYKGLYMSRVNARQQALITWYLCKAQPVNALANITLGDDDGTTDDDIAVLGDLLVAELPQDFEGFDAERREQGGSSNQPFLPWNPSTSPVKHFTDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZA1</accession>
    <name>A0A8J5JZA1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025553">
        <property type="protein sequence ID" value="KAG7164170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZA1"/>
    <dbReference type="OrthoDB" id="6343092at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="418" mass="46551" checksum="633A8CF2FD3C5306" modified="2022-05-25" version="1">MPRMRSVVVYKRASSVDIISEDDYYTQIEKKPREENSFSFFDLPSPICLEVISHLSLRDTRAMALTCRAGWQITRDQLMWRHKLWLRAKVINLGLFGPNFEPNPMAGMLVRDPLLVNNKLLYEILNPDSCNDENHEDLDFGNLLSKMATPTASMGLSELFENMLSIFSSGSPQNSLSDPFSKGEGAPTFLLFGMPETKVSKKLALSFIASKDSTFETVGLVKGKPGGVGGGVTVRYGHHLMNLLTVRRARPRLLVDGPNGTTFHPDVAEVIPRVDGLICYMDATCHCDNSSNKSLYNKKQNVCCTNSHTIDVLELEAMMRTIPSELSPPILVLLAHMDDPQPISNDSDFDGDDFANTCNKSQAYHSGHPARHRPTMLHSVLGTLDLPWAICDVEVKTLVGVHRGLNWLLHRTLKLKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZH8</accession>
    <name>A0A8J5JZH8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025213">
        <property type="protein sequence ID" value="KAG7164549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZH8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="151" mass="17270" checksum="5E54FD3C77B38315" modified="2022-05-25" version="1">MESTRSKTEVWLIGQHITEITVAQLPSRGDVLRLFFHGHNEHKKTVNDSASEVAASVISFWNKARIPTITEKSIGRKVKDLFLMWKGLKKNCTRTTDTQRKKEETFCDELEDLFDVAHPKAMQLLTIKEDRAFLAAQREKGRRGVMAGVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZX4</accession>
    <name>A0A8J5JZX4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Jerky protein-like 75</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">jrk-L75</name>
        <name evidence="2" type="ORF">Hamer_G013183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024020">
        <property type="protein sequence ID" value="KAG7165671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZX4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="99" mass="11232" checksum="080ABC557C6440B7" modified="2022-05-25" version="1">MFTSHSNEDTENDFAGFRVSKEKQLIHELLAYVKDVTNPDAKELSSRINEGVLTEWLDVDDNVPTVHHYTDSEIVDMVKSPERNACTGSDEDESSEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K051</accession>
    <name>A0A8J5K051_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Ubr3-L</name>
        <name evidence="5" type="ORF">Hamer_G019072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010021370">
        <property type="protein sequence ID" value="KAG7167670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16483">
        <property type="entry name" value="RING-H2_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF39">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR1-like winged-helix" evidence="4">
        <location>
            <begin position="380"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR-like C-terminal" evidence="3">
        <location>
            <begin position="1154"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="770"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="894"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="975"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="774"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7167670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1632" mass="182173" checksum="F26F358AD2F2D3BC" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0Q6</accession>
    <name>A0A8J5K0Q6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Synaptogenesis protein syg-2-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Syg2-L5</name>
        <name evidence="7" type="ORF">Hamer_G018433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7168002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0Q6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF136">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="117"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7168002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="252" mass="27212" checksum="CD76BBDEF35DC7C3" modified="2022-05-25" version="1" fragment="single">MGWGDGAVVEVVEGTTLTLECVVTDGRPPPQAAWYRAGLQVDPAIQVDRIEPSTSPRRWTVTSQLRVTALAADDGRLFSCQAVHPTLENGPTSLVASVTLSVLRRYCVVGGGDTPGPPIITGYDPSEVLLAGERRTLSCKSSGGNPRPWVLWYRQGRLLDDTTTTLRAGGGVDDLEEVQGVVNDHELAVTPGEDGAVYECRVTSDLLEFPLTSNVTLTVYCKFTVMTLMMIITTTTNNNNDGDVYIRSADYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1H6</accession>
    <name>A0A8J5K1H6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diaminopimelate decarboxylase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LYSA1-L</name>
        <name evidence="4" type="ORF">Hamer_G002551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1H6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43727">
        <property type="entry name" value="DIAMINOPIMELATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43727:SF2">
        <property type="entry name" value="GROUP IV DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="3">
        <location>
            <begin position="66"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7168482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="281" mass="30804" checksum="D4EFFE3467E4ACB0" modified="2022-05-25" version="1">MSLERLREHLRQEFGHLSSPAFVYSSATLHSSVLRYKDALTPLLVNVARELGVRARALVRLNPALDAHTHPYLATALADSKFGVEVDQIRDSGWQKASMINLGGGLSVSYEPPIDGGYHQEETIPTSLINPTSPLSSKKRITPETTKGVVMTEVMGVKTNAGREFVVVDAAMTEVIRPALYGVHHPICYVTTPSAHQEVAEVDVVGPVCESGDFLARRCFLPRPSASGDALVVWAAGAYCASMASNYNLRPHALEVLVHSPDSYKVLRRPQEFEDLVREFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1X5</accession>
    <name>A0A8J5K1X5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative A-agglutinin anchorage subunit-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G002607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1X5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035145035" evidence="3">
        <location>
            <begin position="34"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7168525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="360" mass="39447" checksum="56040C433D2A02A4" modified="2022-05-25" version="1">MNMRLLRSSRRASCRDVVCVLLLVMTAGGCVRGQTVPDVPCMTNGDCDVKEWTSPQPECISYKCRCPNDTCVVYTYLTDSNNLYYYCGDCGTLGSECNSTEDCMSRWQCSNNVMYSPVPTSVSSLVLIIILAILLIIQKLIHSRKTLKKCFCRKSGDSEEDTETRVVGYNPDSNNKTAAYTITNSDFMTTSDDPDFDWALELSRQMSTRGEEWLLLSSSTWSSLSSSQTDPSSSILPDLSSSQPGTSGWRPRSSSTSVTRSNPTSRPHRRRSTRSSMSSVSSTYSASPPPSSYYSSHSIPYTSSLPSPASSRSTPPSASSTLSSRRSGSDSYRSCPRSSFTPDSCCDPGVANDDVRVSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K221</accession>
    <name>A0A8J5K221_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable arginine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Rars2-L</name>
        <name evidence="15" type="ORF">Hamer_G010240</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of arginine to tRNA(Arg) in a two-step reaction: arginine is first activated by ATP to form Arg-AMP and then transferred to the acceptor end of tRNA(Arg).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K221"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="14">
        <location>
            <begin position="478"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7167836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="593" mass="67501" checksum="FEF63C5270255194" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K269</accession>
    <name>A0A8J5K269_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Intraflagellar transport protein 57-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ift57-L</name>
        <name evidence="5" type="ORF">Hamer_G011736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT57 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7169037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K269"/>
    <dbReference type="OrthoDB" id="423881at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019530">
        <property type="entry name" value="Intra-flagellar_transport_57"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16011">
        <property type="entry name" value="IFT57/HIPPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16011:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10498">
        <property type="entry name" value="IFT57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7169037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="415" mass="48086" checksum="CE88C93257C9CC2F" modified="2022-05-25" version="1">MSARRGPAEEEEEELDGGPGLAYMPFVVMDDLLDKLKLLGYDKDFLVELKMKPLSRHYFALQTNPGEQFYLFTSLSAWLIRKTGRNMEQPQEYDDPNSTVSNILDHLRQLGIAVDFPPNKLKVGYGEHAIFVLDRLADFALKQDNFLWKKPIYPAEDTGGEDGEVKDEAELTLDKVEEEMMAEYDDDDEEENILHMDDLKDLTAQKDGDAWPDEILHSNTTSEEWRLELERVLPQLKVTIRSDTRDWRSHIEQMHEHRSKINETLNFTQKQLDGLHSEISRSLEKISSREKYLNGQLEPLLLEYRNLQNVAAESREQYRVVSTKLVEKSHELAQISDELDRVKHEMEERGSSMTDGTPLVNIRKALTRVRQEITAMDVRIGVVEQKLLQAKLKDKSNMQRDMNAPVYNNMDMGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K375</accession>
    <name>A0A8J5K375_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G028293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015542">
        <property type="protein sequence ID" value="KAG7169772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K375"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="156" mass="16704" checksum="4CCFFADA05DCC57E" modified="2022-05-25" version="1">MPERGRGAVASGGALGSVNVSTLAICVCVTPTGDGWPLPQVCAREGVAGAEGETSSPSAQLCHSARDGRDRNTLWTNGEFRNKVVCPKTQWQSGGGYPSLHYEKGAEFVSVLEPGGGRRGGGGADDRIVAWHRLEETCVLQYQFQDHLQQGDEYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4J0</accession>
    <name>A0A8J5K4J0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G005209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4J0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="251" mass="28812" checksum="E38275E385D69767" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGLVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K531</accession>
    <name>A0A8J5K531_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7168026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K531"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="116" mass="12613" checksum="D71289AB1E5D86D7" modified="2022-05-25" version="1">MQAKLTANQQPFTSAADIATVILQECLPSGTCSAAKSVTHDTNYYRRKHRPKHPNSLDSEVESQHSAENFLHGDILVDDLIFPTDDNFSCSPVQGPGMVMPGSYKPCNSSSVSKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K542</accession>
    <name>A0A8J5K542_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate sulfotransferase 3-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Chst3-L3</name>
        <name evidence="2" type="ORF">Hamer_G021188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013493">
        <property type="protein sequence ID" value="KAG7170807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K542"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="630" mass="72015" checksum="73A21DD33AF0EC53" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K570</accession>
    <name>A0A8J5K570_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Two pore potassium channel protein sup-9-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">sup-9-L2</name>
        <name evidence="16" type="ORF">Hamer_G012335</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K570"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF326">
        <property type="entry name" value="ACID-SENSITIVE TWO PORE DOMAIN K+ CHANNEL DTASK-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="169"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="247"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="50"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="426"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="66"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7170100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="485" mass="54943" checksum="2696DA5B81D291A1" modified="2022-05-25" version="1">MACLAYRRLGRMSCHSRIMERQLDNGEATADTGNAITAIAGVIVGTLNTSSRRTDRQTDGQMDGQTDGRTDGQTDRQTDRRTDGRTDGRTDGRTDRQTDRQRERQADRQTDRQTASQAERERQTDRDRQIEQRQICRNRKRQRDRDRQTDRQTERALNAHFYDRNKTLVIGTLRYGHSTPNTVPGKIFTILYAILGIPLCLVLFHSIGERLNMVSSIAIKQIKKILKCQDTDATEIDLILVVTTLSTITITSGAAVFSRYESWSYFDSVYYCVITLTTIGFGDMVALQKDHALDQKPEYVAFALIFILFGMAIVAASLNLFVLRFVTMNTEDERRDEAEAEGRGVEGMWEGDAAAGAVRLEGDVITANGSILSGQCPQEGASFTDLTSVCSCTCASCAPCHALPFTRSYSFRKRSMNLSYILPRRQRLQQQREQQQQQREMQQREHLQREREQQQVTHTDTQEELCSSSSESDVTPTLAQKRNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5Y8</accession>
    <name>A0A8J5K5Y8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MULE transposase domain-containing protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013935">
        <property type="protein sequence ID" value="KAG7170550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5Y8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="101"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="181" mass="20198" checksum="B062AD3C00F20C9A" modified="2022-05-25" version="1" fragment="single">SQAGHNHAADETNVQYYKCRNQMRHQAASSLDKPGNIVAQAVTQQNKASLRDFTLPDEWKKTLGSSPEQFLLYDSGPEANSLIIAFATKESLHRLAAAETIFMDGTFKTAPTQFTQVYVLRVPFSTTYVSCVYALMQNKTRAVYSELFDAIVDHCTELGLNLQVRTVVTDFEVQSKGCFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6G4</accession>
    <name>A0A8J5K6G4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Calcium uptake protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MICU1-L</name>
        <name evidence="16" type="ORF">Hamer_G013002</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the MICU1 family. MICU1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6G4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15900">
        <property type="entry name" value="EFh_MICU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF1">
        <property type="entry name" value="CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="261"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="427"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7167533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="493" mass="55657" checksum="FDE5EA0C9BC4C441" modified="2022-05-25" version="1">MSGTLLRVLPVIARNRGLASSYVAKRLGILMGNTSVNLGLETQKVARLYSIQRTSVVAACSAKRNNEVKKYWTVDAASVTEADRPKEEEEEAVEEDSSLDSSSEETEAEEDASDKKKKKNVGFRDRKIIEYENRIRAYSTPDKIFRYFATCKLIQRTASGVDRTEIFMTPDDFLRALTPGMQQPQGLGLDQFKKYDPKKKCGITPGVDEISGEMLEEEEVEMNTSNKLELALDEDSIFYKLGSSGLISFSDFIFLLTVLSTSRRHFEIAFRMFDLNGDGDVDYEEFDKGVNSALSTYFFGITLREKLTIEKFLFFQQQLQQEILSLEFRRKGPNDEGLISEADFAELLSAYGGYPTNKKARMLKRVKKAFKGEASQGISRDDYLKFFHFLNNINDVDTALTFYHIAGASIDPATLKHVAKTVAHVELSDHVVNVVFTLFDDNNDGQLSNREFVAVMKNRLQRGLEKPKDTGFVKLIVSMFKCAGETKPVLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7E6</accession>
    <name>A0A8J5K7E6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1391"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1456"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="920"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1456"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1470"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1517"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1528" mass="164752" checksum="5080B0716C1C6BA0" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K9M9</accession>
    <name>A0A8J5K9M9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LIM domain-containing protein jub-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">jub-L2</name>
        <name evidence="6" type="ORF">Hamer_G013319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015640">
        <property type="protein sequence ID" value="KAG7169694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K9M9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035331">
        <property type="term" value="P:negative regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09438">
        <property type="entry name" value="LIM3_Ajuba_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000037">
        <property type="entry name" value="LIM domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047172">
        <property type="entry name" value="Ajuba-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047248">
        <property type="entry name" value="Ajuba-like_LIM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN JUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219:SF4">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN JUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7169694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="90" mass="9951" checksum="5282F1198F2921F7" modified="2022-05-25" version="1">MFAPKCAACGKSITPVEGTGETVRVVSMDKDFHVDCYVCESCGLQLTDEPDQRCYPLDGRLLCRNCHLHRLHAMGRTSSNIQDVGATYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KEZ0</accession>
    <name>A0A8J5KEZ0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BCAP31-L</name>
        <name evidence="15" type="ORF">Hamer_G012527</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KEZ0"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="174"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7170954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="230" mass="26370" checksum="37EA3B59381DD2C6" modified="2022-05-25" version="1">MSIQWTLIAGVMYSELAVTVLLLIPVISPTRWHSIFKSRFLRSIGNMSHIYFKVFLGVLTLFFLDAIREMRKYSTELAEQTRGDHGIHLDAEMQAHMRLFRAQRNFYISGFSLFLWVVLLRLTTLISRLAVAMAEGQAALKQAQSASATAAQLLKQDKAEKEEDQQKEANVSNEIKELQEEKRHLEAERDAALKQAKAISREYDRMLEEHSKLQAELKKATNGEESKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MHH9</accession>
    <name>A0A8J5MHH9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cortactin-binding protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CTTNBP2-L</name>
        <name evidence="5" type="ORF">Hamer_G010677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MHH9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="163"/>
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            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
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            <begin position="485"/>
            <end position="510"/>
        </location>
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        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
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            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7153366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="925" mass="97071" checksum="D39C578845F7ED7C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5MK46_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7154160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MK46"/>
    <dbReference type="OrthoDB" id="6366286at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="110"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="135"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="351"/>
            <end position="381"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAG7154160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    </gene>
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        <name type="common">American lobster</name>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKK8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7154864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="191" mass="20395" checksum="F29214E0F16E2D90" modified="2022-05-25" version="1">MATSREGERATDKECSQSGLLTPPPTPTSPCGFQFPGLGAGLDRGSAFTPWIPRGPSLLPLLPPFPILPTIASVAAAASAKQTSPGLDPRVMGMLHSYHSLGQLPWAALGAGDLALNRLLNPSVLTPTLPKDITLIPLYNYPVKKEAETDSRKHALEALVYPAAKKPFLLTEAEENSGKKRRGFSIDDIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5MMI1_HOMAM</name>
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        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035317898" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="7661" checksum="0F6A76000007A282" modified="2022-05-25" version="1">MNVKIVCFCIGLCVVVSSAVPVAQLTSVEGGDVEKPVDRLDCPALASPPTDVRILTCQRCVVGSTSPPVMTLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MN12</accession>
    <name>A0A8J5MN12_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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            <taxon>Astacidea</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037877">
        <property type="protein sequence ID" value="KAG7157235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MN12"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="131" mass="14450" checksum="496E1A3FEAAA8F77" modified="2022-05-25" version="1">MAAADEYSTTSHVLQLCLALQDRLEKVEKEVQSLKGENLALKLVLEEKKTFASVVKDGDVEVDSWKVVAASATKCTIKRHSAVNLNNRYSTLSDECEEGASNTTSATPSVRVERGSSAVRSNVFLSWETRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MN85</accession>
    <name>A0A8J5MN85_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FucTC-L4</name>
        <name evidence="17" type="ORF">Hamer_G005758</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MN85"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035187396" description="Fucosyltransferase" evidence="14">
        <location>
            <begin position="30"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="16">
        <location>
            <begin position="266"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="15">
        <location>
            <begin position="373"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7157342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="569" mass="65936" checksum="BDE984DC81431D22" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNB6</accession>
    <name>A0A8J5MNB6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate sulfotransferase 3-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Chst3-L2</name>
        <name evidence="3" type="ORF">Hamer_G021094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036637">
        <property type="protein sequence ID" value="KAG7157853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNB6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="2">
        <location>
            <begin position="142"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7157853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="255" mass="30591" checksum="B6E18F7532036445" modified="2022-05-25" version="1" fragment="single">YEPLHRWQQTIVNVDDDDDDDDDDDDDDDKINDINDYDTQKQIKTYLFDLLRCHFYPYPHQVKNMYQQEFYRNANVHLMKTCTPVRKCIDPSFVSKVCRTSAQHVIKVVRLRLLTVMELMEKERELKVVHLVRDPRGVMKYVPRYMFVRYEDLTLNTSKTMMDLWKFLDFEITPRMVQILSKTKTADIKGSTTSRNTQKQAFSWREHMSFRYLQKVQRECLPVFKILGLRVFWSLQEYKNLSVPVLLPSVPPLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MND9</accession>
    <name>A0A8J5MND9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G031084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037064">
        <property type="protein sequence ID" value="KAG7157640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MND9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7157640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="333" mass="37903" checksum="2247B92FAF94B13D" modified="2022-05-25" version="1" fragment="single">PLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMESEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQKLRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERREGAINTISVGQDIQCDCVKILLMVRLKVDCCYEKLSLRDEEEGGAGGGWSRRWVEQEVDVEQEVDVEQEVDVEQEVDVEQEEGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNZ1</accession>
    <name>A0A8J5MNZ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mortality factor 4-like protein 1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G019484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035076">
        <property type="protein sequence ID" value="KAG7158468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNZ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18983">
        <property type="entry name" value="CBD_MSL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000024">
        <property type="entry name" value="Mortality factor 4-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF48">
        <property type="entry name" value="MORTALITY FACTOR 4 LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="232" mass="25572" checksum="5E5074B36782CC61" modified="2022-05-25" version="1">MPDNPPATPAVDKTPFKTKFIESEKVLCFHGPLIYEAKCLKVQVKEKQVKYFIHYTGWNKNWDEWVPESRVLKLSDANISRQKDLQKAHEASLRNKKSKKEKKKIKELGKDGLPIGGSSNAGGSCGNTSGGGEDSRSSTPSTDRSSSGPGKRSAASTPTTPASVKGDDSENRKKRSRLENTVDTNGSAQGPENVVTRTVDDIYSHYAMGMLDSRNYCCYTMKSYLSLKLLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPE2</accession>
    <name>A0A8J5MPE2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G021116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034714">
        <property type="protein sequence ID" value="KAG7158542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPE2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="581" mass="64229" checksum="78C10B49EB2D8F12" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQ77</accession>
    <name>A0A8J5MQ77_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033007">
        <property type="protein sequence ID" value="KAG7159665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQ77"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="244" mass="28058" checksum="352A8D5FE6E7C75B" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSEDPCLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIGRLFVSFKKSSPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRR7</accession>
    <name>A0A8J5MRR7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029630">
        <property type="protein sequence ID" value="KAG7161164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRR7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="88" mass="10135" checksum="C9895EDB27E37FDD" modified="2022-05-25" version="1">MASTSRDRDRGRKYLNGNQKRALAKAKVLENEKHRGAIKKFLVTPPLKRPCIEDEEDKNDSENDNTAISPITVDEYNEEIDIQFEKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MS24</accession>
    <name>A0A8J5MS24_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM151B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FAM151B-L</name>
        <name evidence="4" type="ORF">Hamer_G016296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the menorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MS24"/>
    <dbReference type="OrthoDB" id="413402at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019356">
        <property type="entry name" value="Menorin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21184:SF6">
        <property type="entry name" value="CONSERVED PLASMA MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21184">
        <property type="entry name" value="MENORIN (DENDRITIC BRANCHING PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10223">
        <property type="entry name" value="Menorin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Menorin-like" evidence="3">
        <location>
            <begin position="23"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7161241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="317" mass="34727" checksum="5FEC73E3D094A156" modified="2022-05-25" version="1">MATKSVKGNIVDVADYFPEASDDLSKVIWGHAVNSKEELEKSIADAAMMMLEADVSAGRLVEQGEDDPVIPIMAHPPSTESDLSLEMWIDKVIEANQDGKKKGAKLDFKDLTIVKESLELLKSRTEQINFPLWLNADILKGPVESTAVPLDAGKFLTWCSESFPQATLSIGWTTRFTSADDEAGAYTKEMVEEMSDTLEANSIAQPITFPIRAAFVGQSLESLEWLVDNIPDCSVSVWSSPSDDIDVQALIALRENVGSDTVYFDLPEDQQKAFDEVKDRESSTSAARFQFLPQNTSAWATAGVALASALAALYLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MS35</accession>
    <name>A0A8J5MS35_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028036">
        <property type="protein sequence ID" value="KAG7162065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MS35"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="108" mass="12803" checksum="36B18BD3F343BA78" modified="2022-05-25" version="1" fragment="single">MVVYGCIFSCRMTLDYRVTMPPYGLEFRQFFKQSDSDLFKALSDLMDIVPSTSVGLHQATEKKYSLYAGLYEKWIADMLLKARRERHRKQREYQEKQDQEVAAKQEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MS88</accession>
    <name>A0A8J5MS88_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G014085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MS88"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="98" mass="11697" checksum="4739B5C63165A2C9" modified="2022-05-25" version="1" fragment="single">MIAFRDWGQSEQLKNVKIISDVLFQVDPKQECKNEEKKCEVCSDPHSFSDQECPRWREECRITKVKHTKNLKYRDVLLRVRGSNKKVEQEQENNTNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSC9</accession>
    <name>A0A8J5MSC9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Two pore calcium channel protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Tpc1-L2</name>
        <name evidence="9" type="ORF">Hamer_G007373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSC9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46726">
        <property type="entry name" value="TWO PORE CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46726:SF1">
        <property type="entry name" value="TWO-PORE CALCIUM CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="680"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="8">
        <location>
            <begin position="129"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="8">
        <location>
            <begin position="473"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="743"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="743"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7161737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="851" mass="98459" checksum="C560FC9D84AA59B2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVM9</accession>
    <name>A0A8J5MVM9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVM9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="336" mass="36756" checksum="6CFDBE80E4AA705E" modified="2022-05-25" version="1">MGQCQYCRRVSTMSTTDSASPGKGRKYVMNGGHNSQEALTGKNSGSDSALESAHSYYEEGSCGKQGRGSHSSESSGKYSLRESIGSLGDCERSHSSPGPTAASPIELQVLHSPNNYTVEGSRNVTEGATADEDALRPLQDLSRVRKVSKGSNCSERGSLTSVASVTAVLRARLGRSASLKVRRPRAESEALGHESPAMVTEKRPRRAVSLRLPRSHRRAHDADTNLPTIYVEDSPRSKGQQGREYPRKSSLRRALSLLSMNSLRQESLGHQKPHKPVQKILRQPRRRHTTVRGLSGMAIDAANQSGLQRSNTLYYPTATSMRHAYAARRTYSDQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWW7</accession>
    <name>A0A8J5MWW7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iodotyrosine deiodinase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">IYD-L</name>
        <name evidence="9" type="ORF">Hamer_G012992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWW7"/>
    <dbReference type="OrthoDB" id="41362at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140616">
        <property type="term" value="F:iodotyrosine deiodinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032553">
        <property type="term" value="F:ribonucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02144">
        <property type="entry name" value="iodotyrosine_dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000004">
        <property type="entry name" value="Iodotyrosine deiodinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050627">
        <property type="entry name" value="Nitroreductase/BluB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026:SF90">
        <property type="entry name" value="IODOTYROSINE DEIODINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026">
        <property type="entry name" value="NADPH NITROREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="8">
        <location>
            <begin position="123"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7167525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="313" mass="35049" checksum="B24D0B22191389AA" modified="2022-05-25" version="1">MGLLTNYVVPFLMENWLTVGVACLAVVVVKFVLYWSTLNQFTPDQGKSPSTRTTPAASQPKSGRRNVIESGGVGDADDDELNDPNVVDPLWPEDLEHIPYKHTRMSPEESIKKSQEYYQLMNQRRSIRFFSSDPVPREVIDNVIKAAGTAPSGAHTEPWTFVAVHDPDVKQQLRSIVESEEEINYTKRMGSQWVKDLKGLKTNWVKEYLTEAPWILLVFKQAYSLLPDGRKRNHYYHEISTAIAGGILLTAIHTAGLVTLTSTPLNCGPAFKTLLQLSDNEKLLLLLPVGYPASDATVPKFSRKPLDKIMVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXC3</accession>
    <name>A0A8J5MXC3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phospholipase ABHD3-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Abhd3-L2</name>
        <name evidence="5" type="ORF">Hamer_G010493</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXC3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="112"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7166822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="612" mass="68359" checksum="DCC8D8219492C3F8" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZG6</accession>
    <name>A0A8J5MZG6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PDZ domain-containing protein 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PDZD8-L</name>
        <name evidence="11" type="ORF">Hamer_G020938</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017704">
        <property type="protein sequence ID" value="KAG7169249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZG6"/>
    <dbReference type="OrthoDB" id="10004596at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
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        <property type="entry name" value="PKC_DAG/PE"/>
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        <property type="entry name" value="SMP_LBD"/>
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        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21519:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26547">
        <property type="entry name" value="PDZD8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="10">
        <location>
            <begin position="66"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="318"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="8">
        <location>
            <begin position="762"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="463"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="596"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="817"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="881"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1058"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="481"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="529"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="599"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="818"/>
            <end position="837"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1079"/>
            <end position="1090"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004370"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7169249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1090" mass="120280" checksum="F5324E24C96DE48B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0Z2</accession>
    <name>A0A8J5N0Z2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">110 kDa antigen-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G013415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0Z2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="548" mass="65681" checksum="426A9C68DF4D9146" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N100</accession>
    <name>A0A8J5N100_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Mcm6-L</name>
        <name evidence="17" type="ORF">Hamer_G021164</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="EMBL" id="JAHLQT010012219">
        <property type="protein sequence ID" value="KAG7171413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N100"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000001">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000091">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000004">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="16">
        <location>
            <begin position="308"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="623"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="677"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="625"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7171413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="780" mass="88120" checksum="6402AD06A9AD2A72" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1X7</accession>
    <name>A0A8J5N1X7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011989">
        <property type="protein sequence ID" value="KAG7171679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1X7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035280153" evidence="1">
        <location>
            <begin position="20"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="266" mass="24666" checksum="FC28F813449507A4" modified="2022-05-25" version="1">MRKQITFILPALLISRCYGDFGYGPLGPIGPGPHGGFLGGGPYDPHAANPHRIHGGHHGSLRRLQGGYSPPGYGGTRGGYSTATGYSVFNLGAPVGYSRGGGSGSFLAHGGGVYSPGGSRSGLGGVHHARGGNGIGGSFNGYGSGGSLGGLGSGGSLGYGSGYGSGGSLGGLGSGGSLGYGSGGSLGGLGSGGSLGGLGSGGSLGYGSGRFLGGLGSRGSLGGYASGGSLSGLGSGGSLGGYGSGGSLGSSLGGYGSGGIIKDIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2Z9</accession>
    <name>A0A8J5N2Z9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Kinesin-like protein KIF21A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">KIF21A-L</name>
        <name evidence="21" type="ORF">Hamer_G009584</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01372">
        <property type="entry name" value="KISc_KIF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22248">
        <property type="entry name" value="Rcc_KIF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000011">
        <property type="entry name" value="Kinesin family member 21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056533">
        <property type="entry name" value="KIF21A/B_hel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056532">
        <property type="entry name" value="KIF21A/B_hel_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23203">
        <property type="entry name" value="KIF21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23204">
        <property type="entry name" value="KIF21A_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25764">
        <property type="entry name" value="KIF21A_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 16" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Kinesin motor" evidence="20">
        <location>
            <begin position="76"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="1475"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="605"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1014"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1188"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="422"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="853"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="614"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1018"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1068"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1206"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1229"/>
            <end position="1256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG7172235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1518" mass="168549" checksum="54F07B96290C96AF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3I0</accession>
    <name>A0A8J5N3I0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010922">
        <property type="protein sequence ID" value="KAG7172482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3I0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="193" mass="21926" checksum="A7323400B03F5B7F" modified="2022-05-25" version="1" fragment="single">MLSHPMEFELHLDKDIWNHINVNMFVPMTVDSSRNVVKSKRNINVASMLTTPHPLMGIYLLQRYSSNNLHPSLDLLWIINCYIATLSDWEKWLWVMTNTQCKSCRRPTGSSTSTFLHTKSYRSIITICGELKYIHWQDGSLLVEVSRGVCDSVLSEVLGAPVSCTPHATFNQCRGWYSLRATPILRGKPSGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3U1</accession>
    <name>A0A8J5N3U1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PBDC1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Pbdc1-L</name>
        <name evidence="2" type="ORF">Hamer_G020104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="1">
        <location>
            <begin position="42"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="180" mass="20292" checksum="DDFCCAACFFA16093" modified="2022-05-25" version="1">MPTQAEIFAELGIPGGVAAGAGVGGGGRGAVNAEELENDSTMEELWAMKAMEHSEIHFNLLCAVDPRLLKLTPKDDAIYTAFRNEFPDFNVKKLEEKDLKSAEAKEKWRPFCLAFEKEIEDYSFATLVRIDGEDEYSESNTILVTRIQFFCIEITRNREGLNDAIRTKFKPKPRTKKGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4M0</accession>
    <name>A0A8J5N4M0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F-actin-uncapping protein LRRC16A-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Carmil1-L2</name>
        <name evidence="1" type="ORF">Hamer_G018650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009960">
        <property type="protein sequence ID" value="KAG7173368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4M0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF66">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="224" mass="25543" checksum="EA3E4E47655092FA" modified="2022-05-25" version="1">MGLCLTVCDRVYTYYTTHEENSSHEVDTMVLMDIQPLKRMQQLEELERATLGGTRDMGPCGGFSTQYMCMCDYHALPYREEVAWDVDTIYLSHDTRELYLHDFDYLEQKDLIPIISALEYNTWFRKLRASHSKLSHEAIERILHVVSKEFANKLSLALLSNSNIPLQKLDLSHNPLEDKGLTNLCGLVAKLSPVAGGLLLPLLIAVIIPLQYHYTRTLCCCMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5W5</accession>
    <name>A0A8J5N5W5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009009">
        <property type="protein sequence ID" value="KAG7173739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5W5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="228" mass="26195" checksum="A93616A9D87A8D53" modified="2022-05-25" version="1" fragment="single">MANMASGMYQQMVVPAPYHFHQPQPQPMPAVSQEPEPKKEPKKRKKPSEKVNGEKKKPRIIGQTAYMAGVRQEAGVADGGECSRCNKKKCFKHADANKLYGLNMYYITWYGVNMNYTTCNSVNIHCITWYGVNMNYTTCNSVNIHCITWYSVNMNYTTCNSFNIHYITWYGVNMNYTKSHGMMQQNTKIYCTHHETKEQLPCVKAPAQLHEEVPPHGTMPRLMHGKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7Q9</accession>
    <name>A0A8J5N7Q9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G028400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007051">
        <property type="protein sequence ID" value="KAG7174746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7Q9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035285987" evidence="2">
        <location>
            <begin position="23"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7174746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="182" mass="20564" checksum="ED1297F5B1165E30" modified="2022-05-25" version="1">MNGGNFLLTLTPSIFWAGDATGDAVNFSPERSVNLFNFQLSCYKDDQEKICPAHTPAQLSTDLNLFIRKKATNQLSRLVEKSVHETESSSSSEEDDKDHHVENELFQALYETPPPCRNEKDSDLFQVFPGGETFNKDTFPNKAMRELFIKYNTPSPVCRGAHVLFGQGRLEAQAQQNERQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N817</accession>
    <name>A0A8J5N817_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7175030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916:SF18">
        <property type="entry name" value="IPT_TIG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1381"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1333"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1353"/>
            <end position="1364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1516" mass="169900" checksum="DD7390D7F11B3185" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N888</accession>
    <name>A0A8J5N888_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Solute carrier family 35 member F5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Hamer_G030564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006607">
        <property type="protein sequence ID" value="KAG7174852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N888"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7174852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="249" mass="28143" checksum="3BDAF96A641D5447" modified="2022-05-25" version="1" fragment="single">WFAGNYSYQIALSNTEAGVVNIISSTSGLFTLILAAIFPSSLTDKFTLSKLASVLLMVAGVVLVSLEDLNLESSVVPVGVVWSIAGAILYACYMVFLKHKVPTEDRMDFTMFFGFVGFFNTIILWPGFPLLDVFGWETFQLPNLQHLFYMSVNGLVGTVLSELLWLWGCFLTSSLMATLSLSLTIPLTMFVDIWLKGIKYSLLIYIGAFPMMTSFIAVSLLTHYESWDPLMDGMKYLHRKCWRRNHMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8V5</accession>
    <name>A0A8J5N8V5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oplophorus-luciferin 2-monooxygenase non-catalytic subunit-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Lucb-L7</name>
        <name evidence="4" type="ORF">Hamer_G015180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7174973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8V5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035184504" evidence="3">
        <location>
            <begin position="24"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7174973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="300" mass="33115" checksum="CAB493F9828AC50F" modified="2022-05-25" version="1">MAMIMLSLLTFALVGVLTEGVKAEDMWASTCPDAGLITPCVCTVIDKTLTEMNCSAIASEEELAKVFSQKFTETGFFTLHIEANHHLKVLREGALGNTTFQHIRMYNGALEKVEEGALSASTSTVTHLDFFNNNLKSFPYHTLPSLTRLEYLDLQMNSLQGFPVLSSATLTTLYLSFNPLGELPGDAFINTPALSYINLRKTGIKEVPAGTFTGLPMLSEVDLWANEVHELVEGVLETSSQSWIYLANNNISSIAPNFITGITYGFIDVSSNRLRELKEKVWHPLLDQAIKLDASRPQTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NC81</accession>
    <name>A0A8J5NC81_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA transposase THAP9-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">THAP9-L1</name>
        <name evidence="3" type="ORF">Hamer_G000645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NC81"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP9-like helix-turn-helix" evidence="1">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="2">
        <location>
            <begin position="66"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="139" mass="15756" checksum="48C560EF6034DA34" modified="2022-05-25" version="1">MDLVKKQIAKNSGKPVHAQYAPALRSFALTLNFYSPQANKFIRKTFDTCLPHPRTLEKWYSAVEVKPGFTEASFSALKQVKKSTDETSGNIFSLVMDEMAVRQHVEWDDIIYHGLIDIGTELDDDCLPVAKKALTQVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ND94</accession>
    <name>A0A8J5ND94_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002318">
        <property type="protein sequence ID" value="KAG7177439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ND94"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="886" mass="102481" checksum="B82983AE6A48A332" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T1Y5</accession>
    <name>A0A8J5T1Y5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Rpl28-L</name>
        <name evidence="8" type="ORF">Hamer_G000761</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T1Y5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="7">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7171840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="101" mass="11856" checksum="5EF0F0B532575AEB" modified="2022-05-25" version="1">MSADLCWQIIRDNHAHLLKKRNVKKPFSTNKPGKNLVKTTIKAGPRRALNSIRRFIKFNHYRKDLKKAALRRASAILRSQRAQPFKKARRRTHKVAKKTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T3Y7</accession>
    <name>A0A8J5T3Y7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G009726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T3Y7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18674" checksum="7211A82C609278DF" modified="2022-05-25" version="1">MNLDGRHLVELLTDVPEITLINTGKPTHILGGTLDLTFISTELVPVAQWEMDDELTSDHFATTTTLRMELLPPPPRPPPRWNTKKANWKLYQDELQKWFSNYEPAEDIDQLNQDLTGAIQHAAEKAIPKTNPTKTTGSTMTKSENRITESTHSEDISDNTLPLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TBH6</accession>
    <name>A0A8J5TBH6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009070">
        <property type="protein sequence ID" value="KAG7173715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TBH6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035313671" evidence="1">
        <location>
            <begin position="31"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="163" mass="17565" checksum="1C538DEEBC3B180F" modified="2022-05-25" version="1">MLLLCCSDDVSCCVCCVVVMLVFCSDDVSCCVCWVNMMLLLCCSDDVMFCSDDVSCCSDDVSDFCSDDVMLCCSDDDMFCSDDVSCCSDVVSDFCSDDVSCCVVVILVFCSDDVMMCCSDVSCCVVVMLVLCCSDDDMFCSDDVSCCSDDVSDFCSDDVSCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5THI4</accession>
    <name>A0A8J5THI4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G016391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5THI4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="156" mass="18317" checksum="D0224AF5D7ACC07D" modified="2022-05-25" version="1">MREFYKSDYKEEMQAERKRMRKQVFDEGARDDTVSTKTASDRFRTQTFYPIVDKLIVQMGRRQEAYSVLCDRFGFLVDKSLSQDKVILKARNLVKTYSNDLEECFADEFLLFSNMYPEEKTIPDVKFMKLTYYCTSQGLWSENSDPLSLVAGTTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5THP7</accession>
    <name>A0A8J5THP7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Repetitive proline-rich cell wall protein 2-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Prp2-L3</name>
        <name evidence="2" type="ORF">Hamer_G023812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007554">
        <property type="protein sequence ID" value="KAG7174585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5THP7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="288" mass="31291" checksum="8D69610DBF9593B9" modified="2022-05-25" version="1">MAPMFCTKLFNWNKPGKGKKDSGSRPPLDTVFPEPQDEGEACPYWTHVQCNPPPQNATSRPHTPTHVPLLPAHHPGSPVHHQPGPRSPSSHRRAAHVRSHQVKCGHEVPYYNTTYNSPYHSPHHSPGPNSPVGHSPVHFTPIHHPSAHCSPVHHSPGFNSPVHHASGYNSPVHHASGYNSPVHHASGYNSPVHHASGYNSPVHHASGYNSPVQPAPGYSTNSLHHRGYVLESNYCQPLPPPPPQRPPPPLPGQEGPFPPLPTTTTTTFTTTTTTTTTTFTTTISSWTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TK58</accession>
    <name>A0A8J5TK58_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tudor and KH domain-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PAPI-L</name>
        <name evidence="3" type="ORF">Hamer_G000358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TK58"/>
    <dbReference type="OrthoDB" id="9995375at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030719">
        <property type="term" value="P:P granule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF29">
        <property type="entry name" value="FI02030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="301"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="461" mass="51321" checksum="D2C0E54DC77A63FA" modified="2022-05-25" version="1">MDTGRIKNLILPLGGALLLSGVAGAVLYYITKKDEDEIKLVTARVNHWSTVQVQVPVDAVGLVIGRQGANIKLIQDRTNTNIRISDEGEEGHRLCVISGLEKNITLAQTLILKTVNEQPVIETTEMLVPYGAIGRVIGRNGESIRTISHLSGAKVFVDRDEDLTLSLPYPEDMRKIVLKGSKEQIEAARSLLLEKVVEDEEMRQQIHASATNMFLRARGRQAAHENVSQPSPMNRNNPLFEALSSTNSDRYIEAYVCAVDTASHFWLQVVGQRSVLLDKLVTEMTEYYESAENRELHELDKVDINSIVAAKFPHDNSWYRGQVCNYEHNETDPLQSFVTVYYVDFGDTETVKIDNVSELRTDFLKLNFQAIECFLANIKPESVKGDEAADVFEELTYAAQWKVVMVKVVGYQQAGEKTIPCVQIIDTNGSTDVDVAEELVNRGLAELTNGVSDSSSNPSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKB1</accession>
    <name>A0A8J5TKB1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004075">
        <property type="protein sequence ID" value="KAG7176145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKB1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="101" mass="10577" checksum="F5562E34B6A2CBC8" modified="2022-05-25" version="1" fragment="single">STKLGSVVNSQHGCSCLVVSRCSKFVGVTAGAPQLPHDPEAEHAPTTQPPVTIIMDAEDPSNHRNNKMDSAASTWPTGVCGGDEFVANLPPQLGKVNMIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLE1</accession>
    <name>A0A8J5TLE1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Longitudinals lacking protein-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lola-L10</name>
        <name evidence="8" type="ORF">Hamer_G000057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLE1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016199">
        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008406">
        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035167">
        <property type="term" value="P:larval lymph gland hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007526">
        <property type="term" value="P:larval somatic muscle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045476">
        <property type="term" value="P:nurse cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007464">
        <property type="term" value="P:R3/R4 cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045467">
        <property type="term" value="P:R7 cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF111">
        <property type="entry name" value="LONGITUDINALS LACKING PROTEIN, ISOFORMS F_I_K_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7176865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="341" mass="38174" checksum="AE3C9C4FB227DBEA" modified="2022-05-25" version="1">MGDRMLVLSWKNHSSMFSNVISTFRDKENYTDVTVTCEGKFYPAHKLVLATCSEYFEEIFQHTSCKHPVIVLRDVASKDMEALLSYMYAGVASVAQHDLASLLKAAEALCIKGLAAPDGCETQSSSSSSSGGNNTSSPKSKRRKREDSIPSATGGTNDTCNSNRNLEELSQPAVQNDHQTRLSPYNEHIESRVREEETKEIINTSRDDTRELLVDHRTPQMPEKSELECTPDMPFKDIFDDMQVKEEELDNSVDEQDLSYNSEINYHTLPDGSRQISESDVGLEDQMTQGYFSKYEAPDTNQRNLPLDSSGHVNPPHPDPGDNHKPGPSRMMEVSYGAHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TPL9</accession>
    <name>A0A8J5TPL9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Sidekick-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Skd-L1</name>
        <name evidence="16" type="ORF">Hamer_G021144</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the sidekick family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003473">
        <property type="protein sequence ID" value="KAG7176448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000093">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000158">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000209">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000360">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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                <person name="Zimin A.V."/>
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                <person name="Timp W."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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    </feature>
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        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="616"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="646"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="673"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7153706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="791" mass="84190" checksum="B65B81572228917C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J7R3</accession>
    <name>A0A8J5J7R3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DDX39B-L</name>
        <name evidence="14" type="ORF">Hamer_G009255</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J7R3"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="76"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="261"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7153615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="427" mass="48910" checksum="2938BCFD2B644F8F" modified="2022-05-25" version="1">MTDHETELLDYEEDEDAVEAGVGESNEAAPAKKDVKGTYVSIHSSGFRDFLLKPEILRSIVDCGFEHPSEVQHECIPQAVLGMDILGQAKSGMGKTAVFVLATLQQIDPVDGQVSVLVMCHTRELAYQIAKEYERFSKYMPTVKVGVFFGGLNIQKDEETLKNNCPHIVVGTPGRVLALVRNKKLNLRHLKHFVLDECDKMLEQLDMRRDVQEIFRNTPHEKQVMMFSATLSKDIRPVCKKFMQDPMEVYVDDEAKLTLHGLQQHYVKIKENEKNRKLFELLDALEFNQVVIFVKSVQRCMALAQLLVEQNFPAIAIHRAMQQEERLSRYQQFKDFQKRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAVTFVSEESDAKTLNEVQERFDVNITELPDEIDLSSYIEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J815</accession>
    <name>A0A8J5J815_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Aldh3a1-L</name>
        <name evidence="10" type="ORF">Hamer_G018193</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044460">
        <property type="protein sequence ID" value="KAG7154452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J815"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07132">
        <property type="entry name" value="ALDH_F3AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000003">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="9"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="404"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7154452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="557" mass="62790" checksum="89D8047E0096974A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J8C9</accession>
    <name>A0A8J5J8C9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EF-hand domain-containing family member C2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">efhc2-L</name>
        <name evidence="8" type="ORF">Hamer_G014966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J8C9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000002">
        <property type="entry name" value="EF-hand domain (C-terminal) containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="7">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="7">
        <location>
            <begin position="151"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="7">
        <location>
            <begin position="388"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7154617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="707" mass="78193" checksum="E8A3157C6865355C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J9G3</accession>
    <name>A0A8J5J9G3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GVQW3-like 4</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="primary">GVQW3-L4</name>
        <name evidence="1" type="ORF">Hamer_G022132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044612">
        <property type="protein sequence ID" value="KAG7154290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J9G3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="143" mass="15354" checksum="57CEC49B4FDF8023" modified="2022-05-25" version="1" fragment="single">ACGDGAQACGGGAQVCGDGAQVCGGGAQVCGAEAEACGAPISNSNPQQLLTLGISCLLHRFGWNLCHQPATVQLCTMKIVAETHEITKEAYKDGAMFRAQVFRGHKSFKEGFTFFENELCFERPSTERNDENVQKNDQLVHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J9Y4</accession>
    <name>A0A8J5J9Y4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G015672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043233">
        <property type="protein sequence ID" value="KAG7155067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J9Y4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="262" mass="29759" checksum="31F5BE6BDA9571FE" modified="2022-05-25" version="1">MENAGNIGSRRREGKKYAVEDEALDRIAKEPRKCYGADVPGNRVVQKLMASPANKYMSRNRLTVLVVTVVEDREKMPRKVNYLLSLHHEMDKFEAVYLELHTHMAARIPHGFGTGQGTNPLHDIMAVDVTAREIGYDVGNGELSLDNGSARITCCDSDYENVEKENKKVHEELVRKGINLRKGSGSMTNLFIDCPESPREELVQKEALQEVWSYLTNISLIFNHMRYFLPVNMQTQNKFAMIIVKDLKVETIVDNRVSTFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JAJ5</accession>
    <name>A0A8J5JAJ5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Rho GTPase-activating protein 21-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="512"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="941"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="960"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1363" mass="150364" checksum="3FC1E959BAB809C8" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JAK3</accession>
    <name>A0A8J5JAK3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043734">
        <property type="protein sequence ID" value="KAG7154831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JAK3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="279" mass="31321" checksum="777349128FB21751" modified="2022-05-25" version="1">MKKEADLLPTQPEDVYLARELYGDEIQLLEKGEIKMDCNQTRTVVEHDLRAISNYFGQACILEIGSLITRRISSSVIADNYGLLCPDGRVENLDSTKPCHWAARPWNSWVARTTHKQEGSGRSIKSNGVSGFDLTIWRCYPQTVGQWSAPSQHAISPSRAPTTCDAQVYGQLDASYFAVAVVKADSSITSSVNSKASPVILGLKNSREHWNPLRNTISNVPPLKEHWNLLYKHYLNAPLLKGTLEHHLQYSTDSATELVNVREDEFHKTLGSSYYRAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCP1</accession>
    <name>A0A8J5JCP1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stromal cell-derived factor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SDF2-L</name>
        <name evidence="5" type="ORF">Hamer_G012157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7156002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCP1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809:SF2">
        <property type="entry name" value="GH21273P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809">
        <property type="entry name" value="STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035267270" evidence="3">
        <location>
            <begin position="21"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="4">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7156002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="228" mass="25997" checksum="1A1C3981D400A354" modified="2022-05-25" version="1">MKLSGLICFFTLFMCTYGRGTQHVTCGSVVKLFNAYYKVRLHSHDVKYGSGSGQQSVTGTPQQEDHNSNWLIKRTLKQQCKRGSVEFVQDFGYCYFEGNQLLVDRRRLQHLATRRNLHSHHFSSPLSDKQEISAFGEEGEGDSGDDWVVICDGEEWDRRQSIMLRHVDTDVYLGVTGQQYGRPINGQNEVVGLSRPGVQAKWETMEGVFINPSHFSDDSRIFHDPSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEJ7</accession>
    <name>A0A8J5JEJ7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038355">
        <property type="protein sequence ID" value="KAG7156857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEJ7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="379" mass="40967" checksum="F0E540EC379F804A" modified="2022-05-25" version="1" fragment="single">ASKVKLFNAVRSQLFGYSVDVGLREDLSEASQVNVAESRSVNDKLRLLESQIKLKEVGIHQAEAEAKEAEAKAKEAEAKAKEAELKRKKQIQKTCDCVYSSPGHKAEFCWTRLQPNTGIPAMIVTEETNTSPVVVMAALSKADSMPIGLLSTKGEARESAVSVLASRDFDLFQKSFAKDPDVGTFRPFLSQGTVEVDGVETPVTILRDSGCLQTLIKEGVVAARKTDKYVVLGSLWGQGVAPLVLLRVKSSCFSGIANVTCMHDLPLAGVDLILCNDLAGELQQLEDDMPGVFPLCAVTRSMSMTNDHNVTTDVDDSLSLEGRFANPIASQDISFAVSAVTVRVALIAAQEQDDSLRLLFDQVSDSANDSGLTTRYFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEP6</accession>
    <name>A0A8J5JEP6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tripartite motif-containing protein 45-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Trim45-L</name>
        <name evidence="10" type="ORF">Hamer_G015645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043233">
        <property type="protein sequence ID" value="KAG7155043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEP6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF291">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="315"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="374"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="7">
        <location>
            <begin position="615"/>
            <end position="684"/>
        </location>
    </feature>
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        <location>
            <begin position="36"/>
            <end position="107"/>
        </location>
    </feature>
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        <location>
            <begin position="129"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="202"/>
            <end position="258"/>
        </location>
    </feature>
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            <end position="71"/>
        </location>
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            <begin position="85"/>
            <end position="94"/>
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            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="243"/>
            <end position="258"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7155043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="779" mass="83728" checksum="5834CD14E6392B8A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFX7</accession>
    <name>A0A8J5JFX7_HOMAM</name>
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        <submittedName>
            <fullName evidence="5">Golgin subfamily A member 1-like</fullName>
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        <name evidence="5" type="primary">Golga1-L</name>
        <name evidence="5" type="ORF">Hamer_G012103</name>
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    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7155954.1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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    </feature>
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            <end position="476"/>
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        <location>
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            <end position="626"/>
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        <location>
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    </feature>
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            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7155954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="767" mass="86820" checksum="7EA2326C4ECAF8FB" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFZ6</accession>
    <name>A0A8J5JFZ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G032136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041206">
        <property type="protein sequence ID" value="KAG7155553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A8J5JFZ6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="118" mass="13369" checksum="2D96E6B7E7F0CC1C" modified="2022-05-25" version="1">MGQRSDWAILVQSEFKGKARVAYACLSMSESVNYETVKEAVLKTVEMDTARLADQLAVAHKMYKEEVSHKQGGIRLNRNQNYDRKHKYKIYSNVKQSSPNYSKGGPPNQVSQTTVGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JG45</accession>
    <name>A0A8J5JG45_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative C-type lectin-like 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Clec-L23</name>
        <name evidence="5" type="ORF">Hamer_G016000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041065">
        <property type="protein sequence ID" value="KAG7155628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JG45"/>
    <dbReference type="OrthoDB" id="6351042at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035226504" evidence="3">
        <location>
            <begin position="24"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="152"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7155628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="312" mass="35053" checksum="5D05CDFB1582A5BC" modified="2022-05-25" version="1">MAPAQLLLVLAASTLILVDEVAAGCQSSNQIECRTGGQCIDQNRVCRSGNQCSDGSDEDPKICKFWTNEDSRCGVSNFYCSGSCYQIYQMCASAQCSQQMDPRVCKLVKTGKLYLEPEGMNLTSSVMQLLETAVNSTLVKKLPYCPMLYTRIGDECFAFFSPAKLPWAESRQFCQSIYGDLLFFNNLTTFDNLLGYMRKALLTTDYWIGGRYDLDTNAWSWVNDDTPMPLGSPYWAERYSSSCVPRSLPHTDPFSSPPAALPGAPCYNYLQAPKERTQGWCSALTYEHYYYISDEICQDTHSPLCILTHDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JH30</accession>
    <name>A0A8J5JH30_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box only protein 22-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Fbxo22-L</name>
        <name evidence="2" type="ORF">Hamer_G006545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JH30"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14939">
        <property type="entry name" value="F-BOX ONLY PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14939:SF5">
        <property type="entry name" value="F-BOX ONLY PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="465" mass="52340" checksum="D2723ADD1E83FDE6" modified="2022-05-25" version="1">MSCAATSQDTAYHIGNVLSGSWELTQKIFENLSFREVSRVRSVCRTWADVGAKILEKRRKLHYLTIHPHSIPTTEGKPRYCLAFCSEDWSSKPEVFNIKEESGKLTLLQYLSGSLPSSCDFGLVSATGVIGTVENNYQGHCLESANNLNQEILSFLHQKEPQGRKPNRWCRRSEESGSQKPEETSQKTSPPQKEAASVNSSSSSSTDTKDVSVNKNEKRPCVGYSIEVEQISDSMHQTDAVSLILIPHHPGVQLKFFNLCDVKFLKEYRKDEDMSCDNLTISADEFNHLTSLSQDDHLKALLVQNHKVALGGGIADCLYAGRSNSFSQSSFGVAVSGPNVMAASVIIPKYVDNPKVFEEYMKELKSCGLPEDQSVAFMFTCCGRGYYWYRRRGKPWFDYDNVETKAFRQFFPNTPIFGFFGGGEIGLNHLPKFSRQEEDERAPPKKRKKKMFHQVSTVIVLLSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHR8</accession>
    <name>A0A8J5JHR8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034868">
        <property type="protein sequence ID" value="KAG7158492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHR8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="261" mass="29978" checksum="1197A665DD25F6CF" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHSDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIGRLFVSFKKSSPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYNHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHX0</accession>
    <name>A0A8J5JHX0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spaetzle-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Spz-L3</name>
        <name evidence="7" type="ORF">Hamer_G006084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHX0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000035">
        <property type="entry name" value="Spz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF12">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035159747" evidence="5">
        <location>
            <begin position="34"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Spaetzle" evidence="6">
        <location>
            <begin position="283"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7156348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="388" mass="42859" checksum="9CE47235E5885F88" modified="2022-05-25" version="1" fragment="single">ATPQFSSLPRTEKVALMALCVLTLVALVGATCASSVSHVSIRLGDRAPITYEVSPDAAPHRPPPTRQYPALAPAYPTPPPTRYTTAAPTPSRIAYTPPALTYPTPTTPDTPIYPPPITPARATYPPPTTPAPATYPLPTNPAPATYPPPITPAPSTYAPTTSQEPTTYASPPTTKASIYHPQPYYQPRPAYHPKPVYRPAPSYNPAPSYHPAPSYKHPEPAVPACADLTNSTWCLEDEAYPEYEIKHAIQYHLDKFNSLYADVAELDAELSVERPNTLEEETYLCPSETSYIRPLRAQNTDGKWRVIVNNINVHYKTFTQTTRVEECLTAGDDCPKVPVCYESKCLQKSIYHRFLVYDSYDQYFPFAIETFKLPASCACLLGAYTIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JI76</accession>
    <name>A0A8J5JI76_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cysteine dioxygenase</fullName>
            <ecNumber evidence="4 12">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cdo1-L</name>
        <name evidence="13" type="ORF">Hamer_G006611</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="4 12"/>
    <dbReference type="EMBL" id="JAHLQT010039062">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="543511at2759"/>
    <dbReference type="UniPathway" id="UPA00012">
        <property type="reaction ID" value="UER00537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019448">
        <property type="term" value="P:L-cysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042412">
        <property type="term" value="P:taurine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000045">
        <property type="entry name" value="Cysteine dioxygenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="CYSTEINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918:SF1">
        <property type="entry name" value="CYSTEINE DIOXYGENASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0883">Thioether bond</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="cross-link" description="3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" evidence="10">
        <location>
            <begin position="93"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7156626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="202" mass="23385" checksum="FF5148A46BEDFECD" modified="2022-05-25" version="1">MEVTYLPQIATLNDLVEELHKVFESDSVNVEYVHSVMASYKSNPIEWKNFAKFDRYRYTRNLINEGNGKFNLMLLCWGPSHTSTIHDHADAHCFMKMLSGSLQEVRFEWPKTEEGEEEHEMVEMDRNVLKLNDVCYINDSLGLHRVENASHSEGAVSLHLYCPPFSSCSVFDERSGKKMKCPVTFWSKFGKKMEVKKAKCDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIJ0</accession>
    <name>A0A8J5JIJ0_HOMAM</name>
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        <submittedName>
            <fullName evidence="3">TATA element modulatory factor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Tmf1-L</name>
        <name evidence="3" type="ORF">Hamer_G008872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158235.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
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        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="868"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="945"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
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            <end position="1146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1291"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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        </location>
    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="829"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="882"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1310" mass="142302" checksum="390D529FCE0B5110" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ71</accession>
    <name>A0A8J5JJ71_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038275">
        <property type="protein sequence ID" value="KAG7156948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJ71"/>
    <dbReference type="OrthoDB" id="6351929at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035194830" evidence="1">
        <location>
            <begin position="25"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="139" mass="15188" checksum="EA4853FC6F17D3C1" modified="2022-05-25" version="1">MRMIVSQWTSTMVVVLAVVSSTAAIKCFTCSDCGDSAGTLQECSSSSDVCMKIEAAGHTKKSCVNKAVCSLGTVEHGVVNAWNNFKNWISDFNQDIEISDEAVAKMIECCDDNYCNSSVSKLMNPLFLLLPLLTCLFWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JK03</accession>
    <name>A0A8J5JK03_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Spectrin alpha chain, non-erythrocytic 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SPTAN1-L2</name>
        <name evidence="2" type="ORF">Hamer_G005916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JK03"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="160" mass="18009" checksum="DD03819204AB36A6" modified="2022-05-25" version="1">MWLNICFITEVTPSENTYQNYPPDRPNGHRRDASENMNGDDLPPLPRSAPPLVMARPPVPPSRARYGEQSWVSGPHQASMSHHGGVPHYGQQIGHMVSHHHQVAQHHTGQGAHFSQVSRVSHHQYAYTSQGQSLHPPPPCFVLVPHTIQMQQMVYQVVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JK32</accession>
    <name>A0A8J5JK32_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase II subunit RPB1-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Polr2a-L3</name>
        <name evidence="2" type="ORF">Hamer_G017455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7160007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JK32"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="213" mass="23286" checksum="E54F34F8EBA35EA4" modified="2022-05-25" version="1" fragment="single">RLRDKAAGKYFTIKSLMTLLAAPPSAPTSETLPSLVYKRESERVRVCIHSLPSLLVTPPTMVIRRILMAVCLVSVVVARPDRPAPAGYGYPVPDHPLAYTPPPPEYRTPEPSYRAPEPTYEAPAPSYRAPEPSYEAPAPSYKAPEPTYSAPATSYKAPEPTYSAPATSYKAPEPTYSAPATSYKALDQHTRSCYILQGPEPTYSTPSLHPTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLF8</accession>
    <name>A0A8J5JLF8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein 94-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Tmem94-L7</name>
        <name evidence="2" type="ORF">Hamer_G028713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032842">
        <property type="protein sequence ID" value="KAG7159691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLF8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="536" mass="60495" checksum="C614DB6D79D2F1C3" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLL6</accession>
    <name>A0A8J5JLL6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Lgal-L</name>
        <name evidence="5" type="ORF">Hamer_G006577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLL6"/>
    <dbReference type="OrthoDB" id="6251307at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF176">
        <property type="entry name" value="32 KDA BETA-GALACTOSIDE-BINDING LECTIN LEC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="12"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7156598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="330" mass="33452" checksum="21A74BFC12141C06" modified="2022-05-25" version="1">MAAPIYNPGAPYLAPIPGGFSPGKIAHVTGTFTTNANSFILKLQSGPTGDPTDEIGLCMYGRVVEGVVGRNSFTRAMGWGQEEATNTLALARGQNFDVTIMCDPINFKIAINHDHFAEFNHRTNPATMTYLNIASTSQDMNLACVWIEDSSPPPYAQMAPVGPHYPPISGYEPPPPYSGGPGYSQPFPNQQMYQQSAPPGQYGQAPPPQHSSGSSGKGMLGMVAGAGTAVAGALGASHLIGKSKTNGGYPSSGGSGGGLLNKALGMGGAVGGASMLGGSKGMMGGKAMKYGVPLAGLGALGAGGYMMSKGIGHGFHGSSSSSSGGSSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMP2</accession>
    <name>A0A8J5JMP2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Adhesion G protein-coupled receptor L3-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Adgrl3-L5</name>
        <name evidence="19" type="ORF">Hamer_G019837</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030060">
        <property type="protein sequence ID" value="KAG7161082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMP2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7160876.1"/>
        </source>
    </evidence>
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    </evidence>
    <sequence length="180" mass="20459" checksum="E4397401E31A9BB2" modified="2022-05-25" version="1">MDGSVEQGSTIDGDTLAERLERAVQIVERQYSELEELQRQVKELKRELQHAKNQDTVLEYGVGKDTTPTDPPAESAHSVPQSRNDTTHPGSLRVYPGVHSKLTDSAKRDDREAPVFNLSYVRTLSLEKLTGSDSESNIRTFCRQVEWLLKQDDHRVEAALSRMESPVERRVLQELDNRGM</sequence>
</entry>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
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                <person name="Greenwood S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">GMGI-L3</strain>
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        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Cystine-knot cytokines"/>
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        <property type="entry name" value="Spaetzle"/>
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        <property type="entry name" value="Spz/Toll_ligand-like"/>
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        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cystine-knot cytokines"/>
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    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
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        <location>
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        </location>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7156354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="281" mass="31630" checksum="D691D30CB696826A" modified="2022-05-25" version="1">MTVQFPLADDQHTSTMTLRLVVLLTVVTIVVGESAHVTGTTLYGAHPAPGHHGHQTHHGHQAHRGHQVHHGHQAHHGYQAHHGHQAHRGHQAHHGHQAHHSTHAHTTSGHHEPAVPACAANTTKPWCLEDSEYPIKDIQHAAEHHYHYLLTVYADLVDLNTEVSVERPNTLPEETYLCPSKTSYVKPLRAQNTDGKWRVIVNNIEVHYETFTQTTRIEECLTSGSVCPKVPECYESKCLQKSIYHRFLVYDSYDQYFPFAIETFKLPASCACLLGAYTIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNY1</accession>
    <name>A0A8J5JNY1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNY1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="100" mass="11194" checksum="BFCD210F8716157D" modified="2022-05-25" version="1">MSEATSPPPPPGERRLHHHHHHQMTEATSPPPPPGDRGYITTTTTRKGGYSHHHQMTEATSPPPPPGERRLHHHHHHQMTEATSPPPPDDRGYITTTTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ28</accession>
    <name>A0A8J5JQ28_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47202:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47202">
        <property type="entry name" value="HISTIDINE-RICH GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="596"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="737"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="767"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="797"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="950"/>
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    </feature>
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        <location>
            <begin position="1060"/>
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    </feature>
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    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
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        <location>
            <begin position="1277"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1310"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1373" mass="149465" checksum="550F5F86E825F2F0" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JR77</accession>
    <name>A0A8J5JR77_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3 beta-hydroxysteroid dehydrogenase/Delta 5--4-isomerase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HSD3B-L</name>
        <name evidence="6" type="ORF">Hamer_G007675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JR77"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="5">
        <location>
            <begin position="77"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7160901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="419" mass="45399" checksum="5E4CE9DB25F67932" modified="2022-05-25" version="1">MLNVLIPVAAIYSNTALFMTSGVLPPPLGGSGFLGQHVVFELQKEAQKMHKGKGTPQNSEGEVTAKTAEETNRLRCIKEIRVLDVKPYNPCLVPPAGASTKVVFQKCDVRDLTQLTKAVEGAAAIINCSAVTPNLLREDLGCDDHMYQVNVDGIKNVVSACCRSGVRALIHTSTLSVKVAGTKLLGHTETLTPHIAENNLTLGNYARMRLRAEEIVLGAHDMCTDTGDILQTIVLRPPLLYGEGDPSFVPYILRLASASGNRLPSVGNPAAFLQAAYAGNLGVAHVYALKHLLNGPAGGVQGCGGLPMYVTDDTPPNNLPGLAEPFLHHLHLQPSRNTSYWVLYLLLILSSLWAFVWSLLGYNSEGIPSSLPLLPLHRSASTIIVVSRMRAELHTGYTPAYTWEEARQRSNSYYTKNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JR91</accession>
    <name>A0A8J5JR91_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G025870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031160">
        <property type="protein sequence ID" value="KAG7160638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JR91"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF1">
        <property type="entry name" value="TESMIN_TSO1-LIKE CXC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="143" mass="16091" checksum="97A5A20FD8E96005" modified="2022-05-25" version="1">MILGGLHIEMAALRMAGSWLQGSRWGETLVQADIASPGTANSFLKAAHVTRTRRGHEITAVTLNILQHKAYGKYTEDAQSDGHEPLEFGVWCQQRAECCPQFQYWATTLNLELSIFMFVRSLRESNFSLYMDALAELSVVLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JT86</accession>
    <name>A0A8J5JT86_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chloride intracellular channel exl-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">exl-1-L</name>
        <name evidence="7" type="ORF">Hamer_G002991</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chloride channel CLIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JT86"/>
    <dbReference type="OrthoDB" id="1935530at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053823">
        <property type="entry name" value="CLIC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43920:SF5">
        <property type="entry name" value="CHLORIDE INTRACELLULAR CHANNEL CLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43920">
        <property type="entry name" value="CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22441">
        <property type="entry name" value="CLIC-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CLIC N-terminal" evidence="6">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7163752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="292" mass="32836" checksum="3979FE486F2F96A7" modified="2022-05-25" version="1">MGSVGQPPAVVAGAAAGDKEEVTVYVKAGVDGERMGACPFCQRVFMVLLIKSQYNILRFKVITVNPAKPPPEFKALGLKHVPALIHGDDGYDALDDIIQYLDTKFPGGGLEYNNPDADLATKDFFSKFCFYIKAVNQDPSKLDQALQKLNHFLEKCTSITNGLTNGDTNHENGDEDDHLHEDSIQYMCSDHLTHLDCEVLPKLQHLRVASKALKDYDIPTYLRGFWRYLHAAYTHQVFVRTCPCDQEIILHWHDRPETPKLSHKKHSVIAKEKPKYSFDVPVRASVVTVVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTH9</accession>
    <name>A0A8J5JTH9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Dhc64C-L</name>
        <name evidence="18" type="ORF">Hamer_G006297</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048469">
        <property type="term" value="P:cell maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
        <property type="term" value="P:establishment of spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051235">
        <property type="term" value="P:maintenance of location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008090">
        <property type="term" value="P:retrograde axonal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000002">
        <property type="entry name" value="cytoplasmic dynein 1 heavy chain 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000005">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000373">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001956">
        <property type="entry name" value="Dynein cytoplasmic 1 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
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    </dbReference>
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        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="AAA_9"/>
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        <property type="entry name" value="AAA_lid_11"/>
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        <property type="entry name" value="DYNC2H1-like_lid"/>
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        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
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        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
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        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
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        <property type="entry name" value="Dynein_C"/>
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        <property type="entry name" value="Dynein_C_barrel"/>
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        <property type="entry name" value="Dynein_HC_stalk"/>
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        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
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        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
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        <property type="entry name" value="Dynein_heavy_linker"/>
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        <property type="entry name" value="Dynein_heavy_tail"/>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA_8"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA_lid_11"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="7" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="1859"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2182"/>
            <end position="2333"/>
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        <location>
            <begin position="2553"/>
            <end position="2703"/>
        </location>
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    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2895"/>
            <end position="3061"/>
        </location>
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        <location>
            <begin position="890"/>
            <end position="916"/>
        </location>
    </feature>
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        <location>
            <begin position="3174"/>
            <end position="3243"/>
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    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3375"/>
            <end position="3451"/>
        </location>
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        <location>
            <begin position="904"/>
            <end position="914"/>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7158919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="4614" mass="527578" checksum="CE6B017BEF1CA0EF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTM5</accession>
    <name>A0A8J5JTM5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTM5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="201" mass="22873" checksum="9C7B21F338AA6629" modified="2022-05-25" version="1">MFPSDSPRGKSLRKNRKILNSGSSQREYNGYPAANCQTVNDDLTNTADNRLALWPESIEVDSTYTNTQFNFGSVSSSAPAETSETGPGDYGEHFTCADQPAVQFDQHFHHNQSLPSQIKRLKWHEMPPQDDPILEQKRKRAVKGKMNREKMRGLERGLQDTINVRTGEVSRLIVERNSLQQVNSQLEFELQSLQECDTFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTX2</accession>
    <name>A0A8J5JTX2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MAGUK p55 subfamily member 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Mpp6-L</name>
        <name evidence="7" type="ORF">Hamer_G007784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTX2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11862">
        <property type="entry name" value="SH3_MPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="132"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="230"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="362"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7160994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="565" mass="63535" checksum="736973427A056FD4" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JU35</accession>
    <name>A0A8J5JU35_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030011">
        <property type="protein sequence ID" value="KAG7161099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JU35"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="153" mass="17189" checksum="0A31BED023B5B159" modified="2022-05-25" version="1" fragment="single">VDGSVNKTDKSKLMHKLEERVKSSKPVSRDACAIDAMFLIRTLVNVPATFGEIAKLVLTRLLGFAKRVDFVCDSYKTPSIKDIEHGIRGSDATHTNFIISGPDQKRPKDFNASLKSANFKTALLHFLVKEWKRTSYIEQIRGYTLFVGLDDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUA5</accession>
    <name>A0A8J5JUA5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Msantd-L12</name>
        <name evidence="6" type="ORF">Hamer_G026678</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029892">
        <property type="protein sequence ID" value="KAG7161113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUA5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="5">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7161113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="293" mass="32493" checksum="1CA78D2F9E4CD5FE" modified="2022-05-25" version="1">MIYLATMFARGLSNMEVVREPSAALSETQRMALLRHIEQRPIIEDRSTSNTINYRKRKAWDEITASFNASYPDQIPRSAKQLKRSYEHIKRNARDMRKTSASVPSASLTQSYDPLVLPGPTPGPSSVSSAQFTEVPSTVYRPLFSPSVLVSQVIVPASPVIAPASPNIAPASSNIAPASAVNAPDSLSSDIASPPPAHASNQHLYSVSRASGSRPRSKPRRTRRVTSVYEMLYRLNREHEEEMKLKKEMMLTQKLQQTAIEKTHEKLNNSLDLLDSVLRKAGAAYEAMAKTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUZ6</accession>
    <name>A0A8J5JUZ6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G005101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cadherin" evidence="4">
        <location>
            <begin position="124"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="1594"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7164701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1908" mass="204067" checksum="94C28E3859E041AF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV32</accession>
    <name>A0A8J5JV32_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028841">
        <property type="protein sequence ID" value="KAG7161669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JV32"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="104" mass="12120" checksum="4568EC02154A4E40" modified="2022-05-25" version="1" fragment="single">IVRLRGERLTEVNVWLVENSSKQTPHKVKHFHSAIGVQCPDCQHLVSKILTVLYLHLLYIYNTFKLIVSMQSKMFFTVMADEFQNEHDARSLGKVVKILCPRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVM3</accession>
    <name>A0A8J5JVM3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Toll-like receptor Toll6-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Tlr6-L1</name>
        <name evidence="14" type="ORF">Hamer_G010728</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVM3"/>
    <dbReference type="OrthoDB" id="2015831at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000021">
        <property type="entry name" value="Toll receptor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035153867" evidence="12">
        <location>
            <begin position="28"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="992"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="13">
        <location>
            <begin position="1043"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1192"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1198"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7162074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1226" mass="139083" checksum="69145D132EDAAA23" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVU3</accession>
    <name>A0A8J5JVU3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative gastrolith protein 18.2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G002267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVU3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035187378" evidence="2">
        <location>
            <begin position="16"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7163188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="211" mass="22170" checksum="CED570C1C538ABA9" modified="2022-05-25" version="1">MKVCVLLAAATMTAAKPQTAATEDATTLSADPSPATDPSLAADPSPATDPAPGATATKPSASPTTAPAATGATPLNPSFFGPGLNNQAAIPVNPMVVQHANKVLATHPHLRVFVDVDGTARFTDIYGREVEEVLDQFGHDLAELLDVQEQQELLLQNQQQQQQLQMVRKGEFDRRRKQLELKLLQEFQSNPAAFDPPAGAGASGIGAEGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW74</accession>
    <name>A0A8J5JW74_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Chst14-L5</name>
        <name evidence="10" type="ORF">Hamer_G027778</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010027154">
        <property type="protein sequence ID" value="KAG7162730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW74"/>
    <dbReference type="OrthoDB" id="6344560at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7162730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="240" mass="28267" checksum="0311851FE15C1ABF" modified="2022-05-25" version="1" fragment="single">DKYLSGEPISNYDDEWRSTTQSGETWSQRWFSYWLPALISKGVIQPTEKFTKMLDLSVDAYNFLVRKIDISSPDDLQISVATELYGDIILQTGLGMIYNGRFVALLQASVYGFNNRDKLMEQFGNASFTFQDFLRHVVWTHNLGMMDRHWMTFTEDCEPCRRKYQYILRLENIAPEFNYLLQQVLGYPDTIPFSLTHRSKHHANKSDLHFYNDVPKDIMNTVLNIYKHDIQLFSYNEKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWQ0</accession>
    <name>A0A8J5JWQ0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lachesin-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Lac-L10</name>
        <name evidence="11" type="ORF">Hamer_G021436</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027491">
        <property type="protein sequence ID" value="KAG7162628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWQ0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="184"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7162628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="315" mass="34599" checksum="792743305DE78C30" modified="2022-05-25" version="1">MTEPPVIDDAASSSDSTVDEGSDVFMTCDAHGDPHPIIRWVREDGLRFNLNSTLSVDEYLGRSLTLQSVDRNATGAFLCIASNGVPPTMSKRILLSVKFPPKIVKDGGSGRIGVAMEGVARMICRFHAYPLTEVLWYRGPRERSLYDLTQHLATLTQHFFVDLVTRHHFEHHEWLIAHRLPPPAEITTTTTTTSTTTTTTTTTAPSQLLAPKASTHRPAHQESSQPPFVPWRGFSAIETTTSASQNRFIQEGEAEGSRAAADTHKNQQQTSLGFGSYFDNPTSSSSSIWSSSSSWLRATCTGISVFLVLLFLAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JX13</accession>
    <name>A0A8J5JX13_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G011008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JX13"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="78" mass="8695" checksum="A00E15673A4E98BD" modified="2022-05-25" version="1">MNPASTTVHTDHNIPQDQVTIVDAIVQGPVFHTCAYHALAFLDIVSRVVIEDSWLVVHHYRKRSVHPDELVVLRAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXK1</accession>
    <name>A0A8J5JXK1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXK1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="457" mass="51632" checksum="2205861366A52665" modified="2022-05-25" version="1">MHGNSGWTHGWFSSVGRPGVCEGPPHPSGYEDTHQQQHDDAQQPREFNSGKYSLSERCDPLSGGDGYYMSTLSPHPPAKCCHMRDLPAVSRRYASFKRHTHEELPPSEPLYVKGSKRYSDRSVHPDFSSGQQIDDFRDFRDDSTSHSYLKKSFSAVEFLREVSKKLDHTTDETSQLLDGVETEDNNADSPGLFGTGNIRHCPSSSSSAWQSFVNNLETGEKRQGMMPVLFDDPEGGIKRSSNPFNRGSSDTHHDCPTTTSTARLNFPENTNTLHQHNTMNGSDEQVYNKQDYCSGENTRPVSPDLFASQDPYHTTTPPSFNLQNGNSSTPQRVYNSQHDPHESRAQGSGEQIHESIRHSLGREDCDTARESHIRFSPKISLTRTEDTYRRGLSGGMVRVSTVEGEMILNPRHWRLARTFTGLLGHKKIQFVEFTSEFGEETFRVHREICPWLSDFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K212</accession>
    <name>A0A8J5K212_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short transient receptor potential channel 4-associated protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Trpc4ap-L</name>
        <name evidence="2" type="ORF">Hamer_G016762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020459">
        <property type="protein sequence ID" value="KAG7168132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K212"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022162">
        <property type="entry name" value="TRPC4AP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31743:SF1">
        <property type="entry name" value="SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 4-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31743">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL 4-ASSOCIATED PROTEIN TCPC4AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12463">
        <property type="entry name" value="DUF3689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="769" mass="87660" checksum="228977C0915E4CF4" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2H9</accession>
    <name>A0A8J5K2H9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2H9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="105" mass="10000" checksum="6FEC88C916096990" modified="2022-05-25" version="1" fragment="single">MKTFADGTELLGETNLAKATHTYRHTMQLGMVSALLVGLLAMGDALGLELAGIPLNLALPLPGGLGALGGLGGLGALGGLGALGGLGGLGGIKTVLAVAGIEGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2W9</accession>
    <name>A0A8J5K2W9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016057">
        <property type="protein sequence ID" value="KAG7169532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2W9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="133" mass="14768" checksum="6BAD4AF26F2FF6E8" modified="2022-05-25" version="1">MFLAVQENSDLLGSLRELEDKVWKLERDLRQAESIAGLRDPRSGKRRASRDQLVQTVTRQADTIARLQEQLMMVQKGGEGEGGAEGAREKDGTLSQQEQVAEEATPTGDATKHIILPLREQTNHNLNTVAPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K353</accession>
    <name>A0A8J5K353_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C-type lectin-like 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Clec-L25</name>
        <name evidence="2" type="ORF">Hamer_G010966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K353"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051004">
        <property type="entry name" value="DC-SIGN_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22802:SF458">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22802">
        <property type="entry name" value="C-TYPE LECTIN SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="68"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="212"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="355"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="503" mass="57899" checksum="05E83FD7CBA3D984" modified="2022-05-25" version="1" fragment="single">MSGGYIREWWWWWWWSSFINTTHSTMTGAPLLLLLSLLSLHTDSVWSRYVGQLDSQATAECYPPFTAVYHTCIFIDSSVKGTWYSTRNFCQDQGGDLVKVDSGDFMYYLVRYIHDNGHDQYSYWIGGSDEHHEGDFRWTDGTEVKMGTPFWGDSADQIQEPDGGINQNCMEMARGDHFYFFDVQCDDSVWSRYEGQLDSQPTVFCEFPFTALYKKCIFVDPETRGSWNSTRTYCLEQGGDLIKVDSADFMFYLVRYIHENGYDHVSYWIGGSDEDNEGDFRWTDGTEMKMGTPFWGDSADQIQEPDGGISQNCVFMNKGNHYYFFDYGCRNYAHAICEQVDEEPTIAFLVTKICSYLINIKQMELINREKFSGHDQHSYWIGGSDEHHEGDFRWTDGTEVKMGTPFWGDSADQIQEPDGGINQNCMEMNHVDHYYFFDVQCDGSSRCSEHSSLDRYAEALDEITWSDASSGFIEFGTELIQELQGFGAQGTQKSDSVEAIFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4A9</accession>
    <name>A0A8J5K4A9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin conjugation factor E4 A</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Ube4a-L2</name>
        <name evidence="14" type="ORF">Hamer_G017193</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4A9"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF16">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="881"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7167283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="972" mass="109666" checksum="A2B12F24FD18C607" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K625</accession>
    <name>A0A8J5K625_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Transposable element Tcb1 transposase-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Tcb1-L10</name>
        <name evidence="2" type="ORF">Hamer_G013146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024020">
        <property type="protein sequence ID" value="KAG7165639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K625"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="165" mass="19080" checksum="12E74FFDE4633E6A" modified="2022-05-25" version="1" fragment="single">MRDWPSEMSRRVTTRVDITAVIALYKANHELRDISAQTGVRLRVVHKLVKSYRELGEDMLPFPLPKSGRPKLLSLRTLEVISRQINTRSERETPVFSATSPYAVFGNPYVIPLDLKASVHCRKPLLTERPKENRVKFCKKCAVWGLGSWRSVLWSDMAKIFLDWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8Z4</accession>
    <name>A0A8J5K8Z4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Trafficking protein particle complex subunit 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Trappc9-L</name>
        <name evidence="9" type="ORF">Hamer_G021808</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015749">
        <property type="protein sequence ID" value="KAG7169589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="5">
        <location>
            <begin position="268"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="6">
        <location>
            <begin position="566"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="7">
        <location>
            <begin position="744"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="8">
        <location>
            <begin position="1237"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="997"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1000"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1037"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1064"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7169589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1377" mass="150131" checksum="B11D9EC813FB82F9" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KBA1</accession>
    <name>A0A8J5KBA1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7169060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KBA1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="293" mass="32666" checksum="DC10E1F95A241A29" modified="2022-05-25" version="1">MGVAATVDLFDRMVEGQQRLRSLLQQEEVKEIAETVSSSEEEEEEEEGPPLAASAALHVSPAASAVNFFVKAWGNTTKATVRHAWSALLPQLKLAETKRQHPAELMNQVLETVHSIPAPGFQEVTREDLEEMMQEGNTNDVKDLLEDEEGGESGDAASDAGDTKQRKVTTQKLSLLLGVFTSLQEMIQDIDSESGEREQVIGVIESISRKYQTQYNERVNARQQSLITRFLSQRRPAEEDQQRELEVDENIDDIGEMPEDFDFARRRRRVVMAGAGQWRRRKGGGGQQAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KIR5</accession>
    <name>A0A8J5KIR5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nicotinamide riboside kinase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">NMRK2-L</name>
        <name evidence="1" type="ORF">Hamer_G025453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012844">
        <property type="protein sequence ID" value="KAG7171163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KIR5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="244" mass="28104" checksum="6E092DAC0C069259" modified="2022-05-25" version="1">MEFAPGANASQPRVERRYGVVYITKTRRVGPVTVSELKQHEEALRQMARWLVVGISGVTGGGKSSLANRLHRNIPSHHITQDNYFYPRDSSHHIPAPGCTNYHNWDVITCIDMERMMKDIKTVIGSSPLQYMNSPPPPLDINKPLSSTAVLIVDGFLLFTHKELWELCDLRYFLTLPKEVCWERRQCRQYDPPDPAGYFDLCVWPEYERHLDCVQKLDGITFLEGVKSLDHSYKLIYDEIILTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJI0</accession>
    <name>A0A8J5MJI0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Ran-L</name>
        <name evidence="9" type="ORF">Hamer_G009476</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJI0"/>
    <dbReference type="SMR" id="A0A8J5MJI0"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7153788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="215" mass="24618" checksum="A4E0E37882EB4DB3" modified="2022-05-25" version="1">MAAEQEMPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKLGGLRDGYYIQAHCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDVKDRKVKAKSIIFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALLPPEVQMDPQWQQQIENDLQEASQTALPEDDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJT0</accession>
    <name>A0A8J5MJT0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046276">
        <property type="protein sequence ID" value="KAG7153832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJT0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035296133" evidence="1">
        <location>
            <begin position="22"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="127" mass="14084" checksum="469952853B763258" modified="2022-05-25" version="1" fragment="single">MESVLYSVFVLCLYIQSLVCAGGYETYHLESMGLCKHDKEEASIFIKPWKAAILKVGYLIDSNGTPSSHKIHKCKINVNTADDFGLAAVIEHMKIQGTHDKLTHGWVCQKDYIKVGSSEVKLLGALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKH5</accession>
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        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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        </lineage>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043994">
        <property type="protein sequence ID" value="KAG7154759.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BESS_motif"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="106"/>
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    </feature>
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            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7154759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="259" mass="30024" checksum="38E0C901A6610AEF" modified="2022-05-25" version="1">MNQLDQDEKLIIEVQQYPGLYDQSSYDYRDLRKKESMWQSVADSLGLHARECQARWRVLRDKFVREMRKNVNPKRAGSSALQVYQGSWPLMSQLMFLTSHVKHRPYRAGRRDTYSDAGGTEDEEDGEPSDEEDIEVKHNPTTTTTTTTTNNNNNNLHTTNNIHATTPSRCPTPPNPKRMRTQSFEADFLKLTQTEQELQKVLTTRQGPRVDDEENGERLFCLSLVPVLRRLEPGKRSLAKLQIQRVLHNLEFPQVKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKM4</accession>
    <name>A0A8J5MKM4_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Halomucin-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hmu-L1</name>
        <name evidence="2" type="ORF">Hamer_G015062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="156"/>
        </location>
    </feature>
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            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="197"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="632"/>
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    </feature>
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            <begin position="673"/>
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        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="46"/>
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        </location>
    </feature>
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            <end position="70"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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    </feature>
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    </feature>
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        </location>
    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="877" mass="99178" checksum="6C92EDAE550F7623" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MM75</accession>
    <name>A0A8J5MM75_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Potassium channel subfamily K member 9-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Kcnk9-L2</name>
        <name evidence="10" type="ORF">Hamer_G006625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF291">
        <property type="entry name" value="IP11374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035186060" evidence="8">
        <location>
            <begin position="25"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="147"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7156638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="298" mass="33273" checksum="2B86250DCAF6D973" modified="2022-05-25" version="1">MRQQNVRTLSLVVCTFTYLLIGAAVFDALESDTETERLRIIETVRQELLGRYNISGSEYKLIETVIIENQPHKAGPQWKFAGALVWALDSRDRGREGFLYRVRRRGHPLGYGHFTSVIIKKMKKMLGCTTTEATDVNQLCVTGTLSSIVMTAGAAVFSHYENWNYIDAFYYCFITLTTIGFGDFVALQSVVTLDGELMAINGKLLAGTHESELGEGRVGSYTSIATVCSCTCYPRPHHSPTDSRHRYSIVRSPSRISNLLVEQGGGSKIDPHQSDQFPPLLHDSFMVANYLKTKRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMH8</accession>
    <name>A0A8J5MMH8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Msantd-L13</name>
        <name evidence="6" type="ORF">Hamer_G027063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038508">
        <property type="protein sequence ID" value="KAG7156844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMH8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="5">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7156844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="315" mass="35048" checksum="C2E071C6D006959B" modified="2022-05-25" version="1">MIYLATMFALGLSNMEVVREPSAALSETQRMALLRHIEQRPIIEDRSTSNTINYRKRKAWDEITASFNASYPDQIPRSAKQLKRSYEHIKRNARGMRKTSASVPSASLTQSYDPLVLPGPTPGPSSVSSAQFTEVPSTVYRPLFSPFVPVSQVIVPASPVIAPASPNIAPASPNIAPASAVNAPDSLSSDIASPPPAHASNQHLYSVSRASGSRPRSKPRRTRRVTSIYEMCDKRQEELHKSKLYRLNREHEEEMKLKKEMMLTQKLQQTAIEKTHEKLNNSLDLLDSVLRKAGAAYDAMAKTYEWCCNISEIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPT3</accession>
    <name>A0A8J5MPT3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Low-specificity L-threonine aldolase 2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">THA2-L2</name>
        <name evidence="5" type="ORF">Hamer_G021236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033646">
        <property type="protein sequence ID" value="KAG7159291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPT3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="4">
        <location>
            <begin position="46"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="4">
        <location>
            <begin position="157"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7159291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="293" mass="31538" checksum="1607F764F6C2B8FD" modified="2022-05-25" version="1">MEQQAKICAQNGEGETHMVNLSSDTVTEPSKAMKEAMMSAPLGDDLGGVHPRTLRNLPDGTFSLTELRQLVRGVDDHWPTTALVCVENTQNMVGGRVLPLAWLDELGVLCRELELPLHMDGARLFNAAAALGVPPSRIVKDCASVSICLSKGLGAPALGGGMRQVGVLAAAGIYALDHVGPTLTRDHAYIQEVARAVVECKSEIIKCDPASAHTNILLLECDPEALPPSHLCERMDQVTDEEVAAIGERVVARILPITDTAVRMVVHCDITHEDIQSVINKLKYVIKEFDGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MS49</accession>
    <name>A0A8J5MS49_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029328">
        <property type="protein sequence ID" value="KAG7161467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MS49"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12260" checksum="61FF4F8945CD6458" modified="2022-05-25" version="1" fragment="single">GMDGGVKVWLDKVWSKRPGGLLPKNSLLVWDQFSAHTTENTKRLAKGLNTQLALSLSLSKKCGMSNAMDGTEDNLLYETDSSDDDDDDSSSHDDSELGDEPNSEDFSGFEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MS81</accession>
    <name>A0A8J5MS81_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P30 adhesin-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">p30-L1</name>
        <name evidence="4" type="ORF">Hamer_G021029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028818">
        <property type="protein sequence ID" value="KAG7161689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MS81"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="475"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7161689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="537" mass="59815" checksum="9640C1A2FCE9C242" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSK0</accession>
    <name>A0A8J5MSK0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028380">
        <property type="protein sequence ID" value="KAG7161992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSK0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="184" mass="20232" checksum="579843D70FF50605" modified="2022-05-25" version="1">MWRYGPPLPTTTTRGDAPPHGLHSHYPLGRADKPCPVSIPVANLDPHPPRQPRPPPRPNLDPSPSPRLNLDPLPIPRLNLDPSPRLNLDPSLPPQLNLDPLPHPLSLTSATHPPSAQPRPLPLGNLDPLPIPSRQPWPLPIPSANLDPPPPRQPRPPPHPPQLNLDPLPHPPRLNLDPLPLLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MT16</accession>
    <name>A0A8J5MT16_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate receptor ionotropic, delta-1-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Grid1-L10</name>
        <name evidence="16" type="ORF">Hamer_G007836</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MT16"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="80"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7162321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="377" mass="43266" checksum="50E56C2FC0E6864A" modified="2022-05-25" version="1">MQQPLDKKWGTPADDGNWTGIVGDLQHQKADFSLDVTLSESRSTVMDYSRVYQNDPYVILSPKPSSLPRHLSLTRPFEGEVWMSFLVCTSFMGVILWLLQKAWSWVSGELGVSLVPTVFHTWGIMLLAPIPTLPTNSTGRVLIGWWLLVCVIVTTGYRSSLIAHLSVQGKYPPINTFQDLLNRDGWSWGSYKFEGGNFLYFNGSTDPDVLEINRNMEVFETENWLEHTLAGEFSFIYLKTWIQIFVARHYTDKYGNTPYQYGTTEYPIFGGNVWGFRQISKMKQRLIEAGLLSLWLDDVLKNEFKQNNTEEEGKEQPLYTEQESGQVVLTLDHLQGAFYLSLLGCCLAFGTFLIEIFFHYYHIQDQDLATTARHNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUD9</accession>
    <name>A0A8J5MUD9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026055">
        <property type="protein sequence ID" value="KAG7163986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUD9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="205" mass="23061" checksum="62ECA300E8950672" modified="2022-05-25" version="1" fragment="single">TKHQATTGTKHTKQAATTGTKHQTKHQQQQEQSIRQQQEQCIRQQQEQSVRQQQEQSMRQQQEHNIKQQQEHSIRNKTSGSSRNKASGSNRNKASGSNRNKASGSNRNKALGSNRNKASGNNRNKASGNNRNKASGNNRNKASGNNELERKVSVYEEVYDITYYPVAASSTLTARRLRHFSPGQKLPLKMCSLIEPRVDARGKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MV05</accession>
    <name>A0A8J5MV05_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FRAS1-related extracellular matrix protein 2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Frem2-L1</name>
        <name evidence="5" type="ORF">Hamer_G005019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MV05"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF8">
        <property type="entry name" value="FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calx-beta" evidence="4">
        <location>
            <begin position="33"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="4">
        <location>
            <begin position="363"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7164631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="553" mass="60660" checksum="C691D23E01C41150" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MX55</accession>
    <name>A0A8J5MX55_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Obstructor-E-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">obst-E-L1</name>
        <name evidence="9" type="ORF">Hamer_G005238</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7166941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MX55"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.140.10:FF:000002">
        <property type="entry name" value="Gasp, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF100">
        <property type="entry name" value="GASP, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035180280" evidence="7">
        <location>
            <begin position="26"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="44"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="147"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="215"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="279"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7166941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="395" mass="43422" checksum="F25C8B3EEC4D0F17" modified="2022-05-25" version="1" fragment="single">CLALCPPSVVSMMLVLTNLFSSSLPHHASTGAQESSITPGGSGNWQCPHEFGYYPHEVSCDKYYTCDVGVPTLKTCGNGLAFDASDPDFLRENCDYRHNVDCSGRPELGTPSTRCITRPQHATDDPQSPKDLHGLAQEAAGDFEYEDFLCPKDYGFFPHPTQCDAYWSCDEGKPEFRLCGNGLAFDIKNDTRENCNYFFAVDCSDRPELEPAISTPHCPNLFGIFADPDDCSVFWSCWDGESSRYACAPGLAYDRKSRVCNWMDNIPECKEQREAMQDNFVCPAPGELAATGSFSRHAHPEDCREYFVCLDGIAREYGCPIGTVFQIGNQDGFGQCADPETVPGCEDYYGDLDLSSLRKSQLLLGNLGLQNGNIVTPAPRPRRPVAAPSDVPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXN8</accession>
    <name>A0A8J5MXN8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="3 11">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PNP-L</name>
        <name evidence="14" type="ORF">Hamer_G010490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:27738"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27750"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:13233"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3 11"/>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXN8"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000004">
        <property type="entry name" value="Purine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="13">
        <location>
            <begin position="35"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="93"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7166819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="298" mass="32837" checksum="C46B725F361CC7F1" modified="2022-05-25" version="1">MCLEETVMGDDTPYPFEVIKESADYLLSGTQHRPKIGVICGSGLGGLADQLDERDVFPYESIPNFPVSTVAGHAGRMVIGLLSGVPVMCMQGRFHAYEGYPLWKCAMPVRVMKLMGVSHIIVTNAAGGLNPEYKIGDIMIIKDHINMQGFAGDSPLRGRNDERFGPRFPAMNNAYDKNLIAMAKKIVADMNLTNVVQEGVYVMLGGPTYETVAELNMLRIIGVDAVGMSTVPEVVVARHCGMKVFAFSLITNQCITQYDTDAQANHEEVIEVANIRKKDLQNLARRIIVNMSEEYQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZQ1</accession>
    <name>A0A8J5MZQ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014925">
        <property type="protein sequence ID" value="KAG7169958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="83" mass="9423" checksum="461279C8C3263FF6" modified="2022-05-25" version="1">MTRDSKHKRQLKEARAKSTAKSKRSKKEKENIAKTDDGNSCPTRHPEAAQPSLPPLPSTSCEEYNWSSVGDVKKKKNNNKYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1L4</accession>
    <name>A0A8J5N1L4_HOMAM</name>
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        <submittedName>
            <fullName evidence="6">Tigger transposable element-derived protein 4-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TIGD4-L1</name>
        <name evidence="6" type="ORF">Hamer_G018622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012106">
        <property type="protein sequence ID" value="KAG7171500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1L4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF52">
        <property type="entry name" value="TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="516"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="584"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="965"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7171500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1043" mass="115843" checksum="51DBB9776F082F18" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1R0</accession>
    <name>A0A8J5N1R0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1R0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035209238" evidence="1">
        <location>
            <begin position="16"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="299" mass="29672" checksum="6021E7E4629D5B31" modified="2022-05-25" version="1">MRTLIVVVLAAFVSAKDKREAEPSYGSGHGHGLGHSIGLGLGHGFGHGHGLGHGFGHGNGLGHGFGHGIGHGGDHGHGHVVVTETVHVDHHGGHGGHHGGLIGGYGGHHGGHIGGHHGGHVVVSHGGHHGGHIGGHGGHHGGHIGGHGGHHGGHIGGHGGHHGGHIGGHGGHHGGHVVVSHGGHHGGHIGGHGGHHGGHIGGHGGHHGGHLVSHIHGHGHGHGHGYGHSYGHGEVQSYEIGHGHGYGHGAAYGYKAAVEHPGHGLSFQRKHSYVSPYHSLGYGHGGHSYGYGRGGYGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2I3</accession>
    <name>A0A8J5N2I3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysosomal-trafficking regulator-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Lyst-L</name>
        <name evidence="3" type="ORF">Hamer_G001065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2I3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF86">
        <property type="entry name" value="LYSOSOMAL-TRAFFICKING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="431" mass="46799" checksum="8CF7F3728DAD5B5A" modified="2022-05-25" version="1" fragment="single">DVPTHRFVLIHRAALESPLVTQNLHHWIDLVFGYKQTGRAAVDAINVFHPATYFGYDVESGSDEISREARKAMIKTYGQTPQQLFASPHPSVSNTGPPQNPQAPEVLHEVRGLRWGTYAGSPADDRPILALVQTLKTPAIYVTSISPTELLLMPSHTHVLNSGINKGMNGVYILSSHHHDGIIRCRRLKDTVAHPLVSVPHYDEVMLCSCGSSQVWIGLASGQILVYSVTPSHVSDELTACVPPTFLLAHTAPITHMHVSEAFSVCISGAKDGMCVLWDTNRLSYIRSIGSSGVEVSLLAMSETLGDWASVSPLGSAASVLRLYSINGALVDSAVTPAPVTAITFSSAPEGTAINVIATSLADGLIRLWSVWDLRPVRELRTDRARQPITSLHYTHDNHHLCGITESGILLVWESSLVKTKIPKFITVPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2V3</accession>
    <name>A0A8J5N2V3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pikachurin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EGFLAM-L</name>
        <name evidence="6" type="ORF">Hamer_G009590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2V3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="166"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="4">
        <location>
            <begin position="207"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="4">
        <location>
            <begin position="435"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="611"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="4">
        <location>
            <begin position="653"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="816"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7172240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="843" mass="92607" checksum="8C3F78F7546F738E" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N319</accession>
    <name>A0A8J5N319_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Spectrin alpha chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Hamer_G022498</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spectrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011388">
        <property type="protein sequence ID" value="KAG7172387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045169">
        <property type="term" value="C:fusome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045170">
        <property type="term" value="C:spectrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016199">
        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042062">
        <property type="term" value="P:long-term strengthening of neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048790">
        <property type="term" value="P:maintenance of presynaptic active zone structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11808">
        <property type="entry name" value="SH3_Alpha_Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000154">
        <property type="entry name" value="Alpha spectrin, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000258">
        <property type="entry name" value="Spectrin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000007">
        <property type="entry name" value="Spectrin alpha chain non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000037">
        <property type="entry name" value="Spectrin alpha chain non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000020">
        <property type="entry name" value="spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000006">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000013">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000017">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000020">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000035">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000043">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035825">
        <property type="entry name" value="Alpha_Spectrin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0117">Actin capping</keyword>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="971"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="2238"/>
            <end position="2273"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="2281"/>
            <end position="2316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1216"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7172387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2388" mass="274585" checksum="8FEC4EE60F30A875" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3L5</accession>
    <name>A0A8J5N3L5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MARS2B-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3L5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007999">
        <property type="entry name" value="DUF745"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37161">
        <property type="entry name" value="HDC10475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37161:SF3">
        <property type="entry name" value="HDC10475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035328118" evidence="1">
        <location>
            <begin position="28"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="284" mass="26674" checksum="96B636EFE3BED019" modified="2022-05-25" version="1">MSNNFYRSDKMTHSFWILSLCLGTVLAEDLVKNDLPRDKRGFLGDGGYGGGTGGGGGYGGGAVSGGGSYLIVGGGGGSHGPSAADIANQAAAQATAAAAGLGGAAKSAASAAAGQAAAAASAASQTAQAAAAQKHAQAAQITQAAQGAQAAAFAESALAGQASRAVQAAKVTSSSASGLLANLGQVTAEANALASQAANSLAAIQAFLDGQQAMAWQAQQAANSLNQQQSLVLNDLQSTQAAAAQAQAAASKALAKAKGSGGGYGGGSGGGGYGGGSGGGGYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3Z4</accession>
    <name>A0A8J5N3Z4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010217">
        <property type="protein sequence ID" value="KAG7172866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3Z4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="90" mass="9859" checksum="4266714CF87951CA" modified="2022-05-25" version="1">MTKQEKSSSTTIAVTHEGPMGRGDGTGDCPGSKLPVRHCYWPWGSTVKKIIDQYKVQVRVPREGSKDEPILVEGKTKLSLGSRPPHKGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N473</accession>
    <name>A0A8J5N473_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tigger transposable element-derived protein 1-like 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIGD1-L27</name>
        <name evidence="5" type="ORF">Hamer_G008461</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7172961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N473"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="510"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7172961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="558" mass="63886" checksum="2560C2D91DAAA0CF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4I4</accession>
    <name>A0A8J5N4I4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Ache-L4</name>
        <name evidence="12" type="ORF">Hamer_G024154</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Rapidly hydrolyzes choline released into the synapse.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAHLQT010010223">
        <property type="protein sequence ID" value="KAG7172864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4I4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF12">
        <property type="entry name" value="ACETYLCHOLINESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035342067" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="11">
        <location>
            <begin position="26"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="9">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7172864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="560" mass="63490" checksum="BFF3E2A7242D713B" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4Y9</accession>
    <name>A0A8J5N4Y9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Organic cation transporter protein-like 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Orct-L19</name>
        <name evidence="8" type="ORF">Hamer_G023460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009918">
        <property type="protein sequence ID" value="KAG7173435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4Y9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7173435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="428" mass="47471" checksum="FFCF2582CCF031EB" modified="2022-05-25" version="1">MEWDLVCERSGLSPLFQSLYFLGAAIGEPLLGFLSDRYGRRWVLMVAGVIFSLVAVASALLPLLTLVLASRFILGLLHPSCSVAYVKAMEVCPTKQRTIMGLLITAPFAFTGMMFGAWAYLVRDWRTLQLFCTLPAVLILLQIPFMDESPRWLMVQGRVEEAAKVLHKASCWQGDALPPQQQLTDHLQKLRNQQQTVPKSKAEEYGCVAVWFKDVVLMLRQPTLRKITLALFSYSDDPFLYMVMSSLMEVPGYSGFTPIVVKFGRRPVLSSCFAISGAAILAILITPTAYTTVTLVLALVGKLFITGAYNLLYLTASELLPTCVRSRGLNLSSMMARVGSIMSPFIIGLLALTYRWLPSLMFGTFAALASLIALLLPDSRHKPLPDTTQDVEQLYGRRTEASPTLITNSESLPPLKNQEDIEQETTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6B3</accession>
    <name>A0A8J5N6B3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone-arginine methyltransferase CARMER-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Art4-L</name>
        <name evidence="4" type="ORF">Hamer_G026265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008277">
        <property type="protein sequence ID" value="KAG7173982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6B3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF16">
        <property type="entry name" value="JERKY PROTEIN HOMOLOG-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7173982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="363" mass="40186" checksum="33672A484C3687B1" modified="2022-05-25" version="1">MAAADDYSTTSHVLQLCLALQDRLEKVEKEVQSLKGENLALKLVLEEKKTFASVVKDGEVEVDSWKVVAASATKCTLKRHSAVDLNNRFSTLSDECVEGASNTTSATPSVSVERGSSAAPVMFSLNKGSASCGVKRKHHTLSIQDKVELLKKLDSGVSVRSICDLYSIGASTVDDIKKQKGKLLQFFADSESKKQMSIRKMLNDGRCSQLDKVLIKWFKLSVSEGVELSGEMSILKVGQSYNVNLEVRIEGTTTVSINSLDLKNPYFRYTGVAPQPPPGNNSVSPSESYWATVDAQGAKQDQPLHSSEVSERDFTTILQQVLQPSDPIYMWRLRRNCIRLAKREYETDPRQLLAADVPTRFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N716</accession>
    <name>A0A8J5N716_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Smg1-L</name>
        <name evidence="13" type="ORF">Hamer_G020725</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010006619">
        <property type="protein sequence ID" value="KAG7174845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05170">
        <property type="entry name" value="PIKKc_SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000010">
        <property type="entry name" value="serine/threonine-protein kinase SMG1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000008">
        <property type="entry name" value="serine/threonine-protein kinase SMG1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031559">
        <property type="entry name" value="SMG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039414">
        <property type="entry name" value="SMG1_PIKKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF119">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15785">
        <property type="entry name" value="SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="12">
        <location>
            <begin position="1160"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="1929"/>
            <end position="2269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="811"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1010"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1679"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="3163"/>
            <end position="3209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1684"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="3163"/>
            <end position="3180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="3185"/>
            <end position="3200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="3230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7174845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="3230" mass="360367" checksum="916B225A99958F30" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7Y9</accession>
    <name>A0A8J5N7Y9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminopeptidase N-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ANPEPn-L10</name>
        <name evidence="3" type="ORF">Hamer_G026623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006006">
        <property type="protein sequence ID" value="KAG7175475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7Y9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF294">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="145" mass="16509" checksum="1CA8D2C3C2FCB504" modified="2022-05-25" version="1">MFRSISPNLKSTVYCTGIAQGGEVEWEAAWSRYLTSNTPAEKTQLLAALGCTKHTGILSRYLDMAFTEGSGIRKADSILVLNAVAENDVGHSLAWHYLTRRWQYITSYYALQQALESTNHNIAWINNNYDVIVRWLHDNGYKEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8F3</accession>
    <name>A0A8J5N8F3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proline dehydrogenase</fullName>
            <ecNumber evidence="5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">slgA-L1</name>
        <name evidence="7" type="ORF">Hamer_G009769</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8F3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="172"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7175760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="420" mass="48757" checksum="5B8C95C6B7BFCAEA" modified="2022-05-25" version="1">MERYTPQRKFADRRYQVSSARTYFYVNEAQCEKNMETFINCIDAVSDATHGTGFAAIKMTALGRPQLLMQLSEVIARARQYFTQVTGESGPILFSDIKTDVFEKRFREENILTDNVSVRTWLDNMTYDQKGLIHLFSWSGLIDANILLMSQSPEWSYGTYDLSTYKGRRGDYAKQCDVRVMVDAEQTYFQPAISRLTLEMMKKYNQEKAIVFNTYQCYLKETFNNLSLDLEQSYRQKFYFGAKLVRGAYMEQERARAVELGYEDPVNPSYDATTEMYQECLRECLRRIKTNKLIGETQRIAIMIASHNEDTVRYTVNKMTELGIDPLDKVLCFGQLLGMCDHISLPLGQAGYSVYKYVPYGPVNEVLPYLSRRATENSSLLEKLDKEKTLLMRELWRRLTSGQIFYKPKGNYTPVGAQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8F6</accession>
    <name>A0A8J5N8F6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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                <person name="Greenwood S.J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7176007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAF8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="502" mass="58820" checksum="06ED432DE75852C6" modified="2022-05-25" version="1">MAAHQMTQREEYLKSLNSFIESSSDVINRFTKFPETSETGMETLGYNSFSEEPLLPSASIPSPSADFALTIDADKQRELLIPYKKIAGPDTRQPPSCAGELTACFSKEERLAMYEYTLQSAARVATPPEILPMETYKSVDNQPKELSELELMKAVRDFKRRRQAYRTKVSTKNKSQTQVTREIIHNMMVFLGAEETEPENLHPKEDSVVPANLPENGCSERSNQERKKITSASGPLDEKQYNRTGISGGRDKRDSDRDYETKVRWREKREDDSSSRYKQKHERDYETDSHRKNQMERQVEYEKDMKRSKRESESRRKYDEEYYQARDKRGRESKERYRERKHSTKTLYKYKDHRQKRKDTDDQIYERFEDENKSNNRRKDNAEISPTILSKLEDGKDVGKEENSWDTGLEASVKESCAEDGEISSHESDITCSNKDSKYSPSSRHRKKSKLKKEKSKRKQRKKRKHKTHRHSHSDSEESVSDDSKFRKKSTTDIYSHEESIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAN5</accession>
    <name>A0A8J5NAN5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomal protein of 19 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Cep19-L</name>
        <name evidence="12" type="ORF">Hamer_G000308</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAN5"/>
    <dbReference type="OrthoDB" id="2163581at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034454">
        <property type="term" value="P:microtubule anchoring at centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097712">
        <property type="term" value="P:vesicle targeting, trans-Golgi to periciliary membrane compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029412">
        <property type="entry name" value="CEP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31539:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 19 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31539">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 19K CEP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14933">
        <property type="entry name" value="CEP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7177081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="162" mass="18752" checksum="E69FC7A2BCAC7A9D" modified="2022-05-25" version="1">MEGQLVPLKLGIRTQPPALTLVYRSSAGKERQRVMPVRFLNKFGPVDNVLKEMKERHNEHLQKVPDVRMEKMIRILQEVQKGRTVEEAAANISKEYSVDPNQDLNKLDGEQLAKKKKVMSSSFEKNQLKPGDPDYEYDKQVEYNTSEKVEAGWDSSEDDFWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAS2</accession>
    <name>A0A8J5NAS2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004136">
        <property type="protein sequence ID" value="KAG7176113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAS2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="251" mass="28853" checksum="0CCF13FCF52B86E7" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWQKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSYIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBG3</accession>
    <name>A0A8J5NBG3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Medium-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.3.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ACADM-L1</name>
        <name evidence="19" type="ORF">Hamer_G009203</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a medium-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:14477"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:83723"/>
            <dbReference type="ChEBI" id="CHEBI:83726"/>
            <dbReference type="EC" id="1.3.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.7" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBG3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070991">
        <property type="term" value="F:medium-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000010">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000007">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF2">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="18">
        <location>
            <begin position="40"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="17">
        <location>
            <begin position="155"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="16">
        <location>
            <begin position="265"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG7176396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="420" mass="45616" checksum="309881D6149FA47C" modified="2022-05-25" version="1">MASLRQLLLTGPLARSFVRWQSTSASGAAVKKSGVCFDLSDEQREMQQLARKFSREEIIPRAAELDRTMEYPWEIIKKAWELGLMNAHIPVEAGGMGLGTFEGCIIAEETAYGCTGVQTAMEANNLAEMPVIIAGNEAQKKKYLGRMTEEPLVSAYGVTEPGAGSDVSAIRTRAEKKGDDYVINGQKMWITNGGVANWYFLLARTNPDPKCLASKAFTGFIVDGDSPGLTRGRKEVNMGQRCSNTSGFTLEDVVVPKENVLLDEGAGFKIAMGAFDRTRPPVAAGAVGLSQRALDEATKYALERNTFGTQIVNHQAISFILAEMAMDTELGRLAWMKAAWEVDQGRRNTYYASIAKGFAGDAANKAASNAVQYQAHPVLLQLPTTLLCCLPSPVLLFRLSLALTRSFGYCSSTATSRHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NJW9</accession>
    <name>A0A8J5NJW9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cuticle protein 18.6-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Cu186-L2</name>
        <name evidence="4" type="ORF">Hamer_G030853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000594">
        <property type="protein sequence ID" value="KAG7178241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NJW9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF75">
        <property type="entry name" value="CUTICULAR PROTEIN 62BB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7178241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="70" mass="7790" checksum="285B9C288553A735" modified="2022-05-25" version="1">MWAYEVDARSTGDKKSAREERRGDVVVGQYSAMDPDGSLCVVDYSVAPNTEFQATVTKQSTHENFQSQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T3F3</accession>
    <name>A0A8J5T3F3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Syntaxin-18-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">STX18-L</name>
        <name evidence="13" type="ORF">Hamer_G022028</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010848">
        <property type="protein sequence ID" value="KAG7172514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T3F3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="288"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7172514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="380" mass="43591" checksum="6F41A6B278A611CD" modified="2022-05-25" version="1">MTVENAASVDLTILFKSCVKTIRTRNKAMGVTLPQTKIFPSAPTPSSQFYSRVKDVMSNIASHRNLLKDHRKKYLQEQDQSMSDYERSYMEKASNVVNTNLRIIDDNIRTLSIELQGDKQGSKDACECQENMVAVLRMKFQEINSSFKHMKELRRTKQKEKDRLYRVQRPAGSKKRTSSSSEDPRRAPQLSQLGKKESSPDTCSSSHPESWGQSTDSQSTDKISPESSQHTERKEGQTPENKAEVSGTTDAEKSRVSSSLLEEEMEKMHGELSAEERQMLEKENAHLYKELMSNQEEVRQITRQVVELGQMQDLLSENVDLQAHQIEEIQETIMAATENVREGNEQVREAMRKDAGFRVWIMFFLIVMSCSILFLDWYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TE25</accession>
    <name>A0A8J5TE25_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TE25"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="49" mass="5277" checksum="C22204AF418CA99D" modified="2022-05-25" version="1">MELSTHLSTFHEVATSLPSSPALKMVFFLMATLIHLSGPSEGKVKCSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TI31</accession>
    <name>A0A8J5TI31_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Deadpan-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dpn-L5</name>
        <name evidence="9" type="ORF">Hamer_G020696</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004953">
        <property type="protein sequence ID" value="KAG7175649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TI31"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11410">
        <property type="entry name" value="bHLH_O_HES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000009">
        <property type="entry name" value="Transcription factor HES-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="83"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="8">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7175649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="495" mass="53476" checksum="0EA5881B7E0980D0" modified="2022-05-25" version="1">MEDQSSAVECGSQAGSDVRSVHHHQRHHQLGANTEQYLDQEPDRLGHEDDYYDDEEVGTDDMRADNISNSCRHTASPADSSMSRKSNKPLMEKKRRQRINRCLNDLKTLVLEGSKKDPSKYSRLEKADILEMTVRHVQALHRHEAAAGGRLVGGGRLVIGEEGKYRAGYTHCVREVAKYLATLSDLPQDLHNKVLSHLNAIASSVSSNVNSNATSVQNNVNVMPNPAPIILVLNTTAGAPVPQQPPLTQSITFQENGGNSLGAQPQVTLVSTPRFQQQQLQQCGLQIMPTHLNNGDLALVLPATQQVVSHSSSNTRAPPSAALQASAPVLTAILTSDRNSSISSSSFVQPPALSTSSDDSALGTETLDTSDSDISCSGISTPMSLSSAGSPVPVEETGRTSPKRAGSSRASPPPRARMWNSSIFREELGPPSSSSSSSCPNRSSTTRRQPVLAPKPTYPAWPSRSAPNDYPPRIRIEKSPPPPPAEPQSMWRPWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIV8</accession>
    <name>A0A8J5TIV8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010216">
        <property type="protein sequence ID" value="KAG7172938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIV8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="63" mass="6424" checksum="7FA97A9AE2D2D2C6" modified="2022-05-25" version="1">MDGGLCLPVCYTQPPLPTSIPLPLNQGDEDMDTDSESDNGDDADTDSDSNGSSGTGSDSDNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLC6</accession>
    <name>A0A8J5TLC6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RSL24D1-L</name>
        <name evidence="8" type="ORF">Hamer_G022910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homologue, RPL24.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007332">
        <property type="protein sequence ID" value="KAG7174693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLC6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="7">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7174693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="197" mass="23049" checksum="369985DA641125A6" modified="2022-05-25" version="1" fragment="single">LVFIDGLNTHWSSSPWCSKRPQLRPRQGSHIKVYPGHGIQFVRNDSKIFKFCRPRCHKNFKRKRNPRSVRWTKSFRKAAGKELTVDPSFEFEKKRNIPVKYNRELWQKTVEVMKKVAKIKTKREGKFVMDRLLKSVEIQRVADIVEVKKGMSLIRSPAAGLRRGNKVIDEEEMEMEDDEVAKRLEAGPSKGVSENQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TMF3</accession>
    <name>A0A8J5TMF3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TMF3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="94" mass="10723" checksum="A46A33D6E60A3A1B" modified="2022-05-25" version="1">MKNLKTVTPQDPPEAEELLRYFESTCVSGSFQQPVAMPSDALMPLRMRHTSPMFAPHLWNVHDVTMNNNAITNNICEGWNNKLFNLVGHYHPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TNL2</accession>
    <name>A0A8J5TNL2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Collagen alpha-2(IV) chain-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Col4a2-L1</name>
        <name evidence="11" type="ORF">Hamer_G016937</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the seminal plasma protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7175982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TNL2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051666">
        <property type="entry name" value="SP_Capacitation_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22918:SF1">
        <property type="entry name" value="FIBRONECTIN TYPE-II DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22918">
        <property type="entry name" value="SEMINAL PLASMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0176">Collagen</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="10">
        <location>
            <begin position="87"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="10">
        <location>
            <begin position="147"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="10">
        <location>
            <begin position="205"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="512"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="657"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="932"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="742"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="994"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1089"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1120"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7175982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1156" mass="126258" checksum="FCE8C4890BBA62E0" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J8M9</accession>
    <name>A0A8J5J8M9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Glutamate receptor-like 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Glrk-L43</name>
        <name evidence="17" type="ORF">Hamer_G015054</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J8M9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035285967" evidence="14">
        <location>
            <begin position="29"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="15">
        <location>
            <begin position="76"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="16">
        <location>
            <begin position="76"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7154692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="485" mass="54904" checksum="57A2A512DB1737CA" modified="2022-05-25" version="1">MDVVKVAGLTFYLVLGAHLLLLVTGAVAQSSAEKYRAWWQKEARLGSAEAARGGNILKFRFEKAPTLLVAAEEWLPYTKVTWYNDTFASVSGPSRKLLDVLSSTLNFKYRFVRGDGYFGALEKDGSWNGMLGMLHRQEVDMALGPIGVTYSRSKVANFTVPLGQEYFRIMTGRPRPLPDPWTIAAPFTWMVWICLLVSLLVMWMVSFMVAQLVIDFRGPRGLSDHLLTVFAVLVSQGVTWEPKGAAMRITCITWMFFSLIVTSYFKSSYTSLLTVKSLPATHDDLRDILNDHNLTFLLEDNTSFKAFVQESEQSIVKEISKELKRRGRFLKASELQEVLERDLPDRGHAALLEEHTIKKYMSINLSKTGRCNFYMSRSYSYSIYISMAVSKGSPLLDLFNARILSLREYGIYAQWVTEELRGASHCYLASNRVTEIAPYTLVDMKMSFVLLGGGTGLAALILLWDIITHWLLVRRPNKASKITRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J8R9</accession>
    <name>A0A8J5J8R9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 16-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">VPS16-L2</name>
        <name evidence="2" type="ORF">Hamer_G023379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045429">
        <property type="protein sequence ID" value="KAG7154080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J8R9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="1">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="172" mass="19489" checksum="B752E34F59DD44C0" modified="2022-05-25" version="1" fragment="single">MEWGGGINLGDFMVAAAHGFLLSLGWSRSEDLVCVQEDGAVSIYDMFGTYQHTFNMGQEVKDTHIQSAQIFTSHRETGVAILSKSNRIFMVSNIYEPKTRKYPDIPGGVVECWCVVREERHTNVLVSQGRDLLLLNHIEQRPQPLLWIGSSDIRIKYCEYDAKSQVKPKQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J913</accession>
    <name>A0A8J5J913_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cuticle protein 6-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Cu6-L6</name>
        <name evidence="5" type="ORF">Hamer_G015059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J913"/>
    <dbReference type="OrthoDB" id="6351272at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035249643" evidence="4">
        <location>
            <begin position="25"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7154697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="233" mass="25988" checksum="866A6D9DF4E33745" modified="2022-05-25" version="1" fragment="single">MVCVVIRAALMVVVATLLVGRSSAGVLPVSHSEYQDLPRLSTFQDVHHQVSHNPDGTYHFSFSLPQQSRAEERDADGKVTGSFAFVDPIGKEVSVRYDADDEGFRPESDALPQAPEDTEDVARAKEEFLRYYEQTAKFLKELASDEDEESSEESDEDDDDEDSSSEEDDSDESDESDESDESDESDESDEEEEGGRERIDAPVAVPQQLATNSVFFPYNADTFFGNRVFTNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J9U7</accession>
    <name>A0A8J5J9U7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATPase family AAA domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">atad3-L</name>
        <name evidence="12" type="ORF">Hamer_G014937</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
            <location evidence="2">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J9U7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001717">
        <property type="entry name" value="ATPase family AAA domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021911">
        <property type="entry name" value="ATAD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075:SF0">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075">
        <property type="entry name" value="PUTATIVE ATP-ASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12037">
        <property type="entry name" value="ATAD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="303"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7154591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="555" mass="61787" checksum="9BA763FA650FCB86" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JBL8</accession>
    <name>A0A8J5JBL8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043090">
        <property type="protein sequence ID" value="KAG7155115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JBL8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="676" mass="75457" checksum="308027419666BEE3" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCH3</accession>
    <name>A0A8J5JCH3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Perlucin-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Plc-L2</name>
        <name evidence="3" type="ORF">Hamer_G026630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042954">
        <property type="protein sequence ID" value="KAG7155161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCH3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="132"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7155161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="263" mass="27965" checksum="45C5A31673C1736A" modified="2022-05-25" version="1" fragment="single">SVSVVLCGGGRGPAAPLCSHDLVLINGGNHIAETNPGLPTQGVTPGLPTQGATLGLPTQGATLGLPTQGATLGLPTQGWCAVGVEGDKDCNDDDGDNGVWPVCVISLGQEGKYQSTQVPDSQQVSHGVSHEVGGSCYFYGYFPLNWFRAAEFCHSFGSGVSLATIETLQENYFIKKWLAVNGHHNTGVWVGGSDNGHSGKWAWFPTGQLVSYSNWGPSQPSGGDQHCMYLVGGLLGYQWADFHCEFDMHFLCEHGVNTVEPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDA3</accession>
    <name>A0A8J5JDA3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Single-pass membrane and coiled-coil domain-containing protein 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Hamer_G006045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDA3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="DUF4519"/>
    </dbReference>
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        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34644:SF2">
        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15012">
        <property type="entry name" value="DUF4519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7156317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="59" mass="6894" checksum="E5A632CC92D8B3FC" modified="2022-05-25" version="1">MRQLKGKVKETAKEKKERKKEFMENKDKAFTVALPVLGAVFLLIAILVYFKTRPKEIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDV4</accession>
    <name>A0A8J5JDV4_HOMAM</name>
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        <submittedName>
            <fullName evidence="11">Zinc finger protein 26-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Zfp26-L2</name>
        <name evidence="11" type="ORF">Hamer_G006563</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1023"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1048"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1075"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1104"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1132"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1160"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1188"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1217"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1245"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1273"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1302"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1330"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="196"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="472"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="734"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="954"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
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            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
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            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="763"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="793"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="816"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="961"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7156587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1365" mass="148480" checksum="7706B5AFB757AC95" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEI6</accession>
    <name>A0A8J5JEI6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein 62-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Tmem62-L1</name>
        <name evidence="2" type="ORF">Hamer_G005974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156255.1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN 62"/>
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    </dbReference>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
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            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="582" mass="66233" checksum="5D62AF9E53054E04" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHX5</accession>
    <name>A0A8J5JHX5_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
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                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
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                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
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            <end position="107"/>
        </location>
    </feature>
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            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="130" mass="13825" checksum="075F5E6624CCAC3F" modified="2022-05-25" version="1" fragment="single">MCCVCDVGKLLKCFSCCEMCCRECGVPGIGKNNTPVHRHTLSTPPSHSQHTTSLSHLYHLQCQGSLVGLTSDSECEDKKSSASSTGAAEVGRPFPSASPQSQGAVVSSHDYNMEQSNVALLRAELKVKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5JHX6_HOMAM</name>
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        <submittedName>
            <fullName evidence="4">Cytoplasmic dynein 1 intermediate chain 2-like 2</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="primary">DYNC1I2-L2</name>
        <name evidence="4" type="ORF">Hamer_G006452</name>
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    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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            <taxon>Pleocyemata</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5JI46_HOMAM</name>
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            <fullName evidence="3">Putative golgin subfamily A member 6-like 3</fullName>
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        <name evidence="3" type="primary">Golg16-L3</name>
        <name evidence="3" type="ORF">Hamer_G023564</name>
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    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="317"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7156070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JI54</accession>
    <name>A0A8J5JI54_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="4 5">
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        <name type="common">American lobster</name>
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            <taxon>Nephropoidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040118">
        <property type="protein sequence ID" value="KAG7156085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6365595at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="212"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7156085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="684" mass="75314" checksum="186D0F5CE1CC4614" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JK36</accession>
    <name>A0A8J5JK36_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033086">
        <property type="protein sequence ID" value="KAG7159642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JK36"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="273" mass="31491" checksum="E6F401A509B0E596" modified="2022-05-25" version="1">MANNHQWEAVNRVLRGLQLPEGPTADLWRSFVVELYNKVEQWEEVERRRYRHSQWDFGVIHTKHPGDLEIVDSFRRLVEHTLGITGRSLADVELGDNTLAEASRMVENSNKVFILASKHLNRPGVHKFIFQDALMTEVLQDRWRSKIIPLKVPGEPRAVIFGLNNIEGLTLDEERHRNRILRQRTERLQQIREVVEGLRQEFGDDYDPTEQLQQMTSQLRLVAEDYMDGGVDQVINMSGCSNVTVGPSYHFAVSRATPSALTPHHTDHLPYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JK47</accession>
    <name>A0A8J5JK47_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pro-resilin-like 73</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G016530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JK47"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7159150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="165" mass="18345" checksum="930B7FBDF3230420" modified="2022-05-25" version="1" fragment="single">CFATCFYCHIVGPPPFMSVLSPSEDVRDSKTKQSRGITAPPNMAQKVHTTVQIIVLAALVVVTLARPDYVPPSPVDPPRYDFNYAVKDYNGNDFGHQESRDGYNTEGNYYVQLPDGRLERVNYYVNGDSGFVAQVEYEGEAQYPAYQPSPSYGPSPSYQPEPSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKP9</accession>
    <name>A0A8J5JKP9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G020862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031693">
        <property type="protein sequence ID" value="KAG7160062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKP9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7160062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="296" mass="34635" checksum="7CA76B9E5836DD37" modified="2022-05-25" version="1" fragment="single">MGRRICNSELKNMADNTTRMMLSPVGVRRRVIRRHLTLEQRRLLRTGLWLRTLMSVLLISLCAVLVIVGMMFLSAYVHQHYPINVDSKYDKDQVSRTKETSRPYKCHAERPPSAANTVSLDFLNPLYQYFDIFENFNVVYVFNLLSSHVSFPDILSLIDQEEESEMDYQEEEPEMVYQEEEPAMVYQEEIENRSKSDDDLTLLNSETSRSDPVVLDTSDDEMEERKVEGEFPSIRKVLKLDDGSTSEVVIDQNKGDPRRLRLKVLIANYNDRYTSHKYLGQKQIQLSHIWQLEDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKY6</accession>
    <name>A0A8J5JKY6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myelin expression factor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Myef2-L</name>
        <name evidence="5" type="ORF">Hamer_G006057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKY6"/>
    <dbReference type="OrthoDB" id="610462at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="65"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="224"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="518"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7156328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="587" mass="62438" checksum="81D98FCAE19BA5BE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLT9</accession>
    <name>A0A8J5JLT9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 49a1-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Cyp49a1-L3</name>
        <name evidence="9" type="ORF">Hamer_G021834</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035368">
        <property type="protein sequence ID" value="KAG7158381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLT9"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11054">
        <property type="entry name" value="CYP24A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000006">
        <property type="entry name" value="Cytochrome P450 302a1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7158381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="529" mass="60546" checksum="CAB29A4419916931" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JM00</accession>
    <name>A0A8J5JM00_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G014841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035946">
        <property type="protein sequence ID" value="KAG7157975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JM00"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="151" mass="17179" checksum="FFAA8B1E03025024" modified="2022-05-25" version="1">MEWDEENSEKRQRKQHLHVHNINTELGYSVLKFSLAAVIHGIQFHSASPARRCVEGGLFGQKSWACVLIPLLFMKNVSVLRSCGDDVWLAWEARSFWQAWCPSSWWYGSLGNTDDNGTIVPLHSLIGHQGSIFSVNFVMTRKITTTLMTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JM90</accession>
    <name>A0A8J5JM90_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mevalonyl-coenzyme A hydratase sidH-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sidH-L</name>
        <name evidence="3" type="ORF">Hamer_G006275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JM90"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006108">
        <property type="entry name" value="PRK08259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802:SF1">
        <property type="entry name" value="IP11341P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="312" mass="33250" checksum="6E27212AD5E28C8B" modified="2022-05-25" version="1">MSLSKRIMTALVALGRRSRLLSICRSIVGAKAMSTSGKTESSAQEGTVIVEHLPEITMIGINRPEKRNCVNTSTAVALLQAFQDFDKDDSAKIAVLYGVGGNFCAGFDLKELSEKPPERLSSSDRGPMGPTHYETKKPVIAAVEGFAVAGGLELALWCDLRVVEDTAVMGVFCRRFGVPLIDGGTVRLPAIVGLGRALDLILTGRAIKGKEALEWGLANRLVACGTAVGQAVNLAQSLVKFPQECMLADRASALHATFSAKSLQESLQFESENGIPIILKESVLGAQKFIGGVGRHGKFNLDHKIGSENSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPA4</accession>
    <name>A0A8J5JPA4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine protease</fullName>
            <ecNumber evidence="4">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Atg4c-L</name>
        <name evidence="7" type="ORF">Hamer_G010764</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPA4"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF52">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="6">
        <location>
            <begin position="294"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7162107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="766" mass="86221" checksum="0D7B074B67F6F9BF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQD2</accession>
    <name>A0A8J5JQD2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M-phase phosphoprotein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Mphosph6-L</name>
        <name evidence="2" type="ORF">Hamer_G010813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQD2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019324">
        <property type="entry name" value="MPP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582:SF0">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="245" mass="27799" checksum="9061DEEBD0BCDCBC" modified="2022-05-25" version="1" fragment="single">MQKPLAKKLSKGVLDLKFMKKSKEKAQLQEENEERQHLYQNQLSSLLDGADRIVMLNSYFDCMEFLPCRLSFGGMDPDIEKINDDKLTGIYKVIKAPQPETGTQMDTDVAAEEMATVFYQSSKRKSDHLDDYDTGTKRDLEDDASERSYVKGCKYKREGDDQFQQIRVGGDSDRGNGSNHDRGSFSDRGRGQRRANFRGDGRGRNQGRGNFRGKDRGRSQGRGNFRGNDRGQSQGRGNFRGNDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQR3</accession>
    <name>A0A8J5JQR3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glutamate receptor 4-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Gria4-L3</name>
        <name evidence="12" type="ORF">Hamer_G007936</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQR3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035172865" evidence="10">
        <location>
            <begin position="17"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7162405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="234" mass="26504" checksum="7A3E6B03FDB130C3" modified="2022-05-25" version="1" fragment="single">ILVGWWLVFCLVISTGYRSSLMAHLTVQGISDTLDTFQDLLDQDGWRWSTEPWQFSGATLEYFSKNTDPVVKKINDAMEVYVIKESLEKVLEGGFSFISVKNYVKVFVSSWFANNKGETPFYISNNGIYVLLCFGWGFRKGAPFYAKFNLMISRLEDAGIIEYWTEEVIDKRVKENREAATLDLVKDTPQADTQVVLGMHHLQGAFYLLTGGSGIAFIILLLEKYGSNRAAPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQV8</accession>
    <name>A0A8J5JQV8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Centrosomal protein of 170 kDa protein B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Cep170b-L</name>
        <name evidence="2" type="ORF">Hamer_G017483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7160030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQV8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="418" mass="45959" checksum="51971E33C9DB586C" modified="2022-05-25" version="1">MHYGGLVQCADYFRNKSQGSVGHRNTSGTKICGQGDEAWKYSVPGNSNYKNIMCDKKTGYRKVAQDLHINRSLSVYNRGNKSSLPKANGSNRNTLSQMNRSKIVERGEVRVTPGIRMSPKKVDFISFIAWRPEAKQLPVIKVEERSGKPPVGRPRSGTIGATGLQQGRRGGGYHSEGYFSSDQDDEGPRRTDLKSPHSPRTPELRSPQTPQRLVRSSSQDSAKGASLRMRTPSPDNASRASHAMTLNESASYLIEKLMNNTPESQRYDPMLTQALELMKQPGKTEGRTCCKADKKPTVAEVTGRSKSEKGTKSTVKMTPEGQKQSNSANSLSSCQTYDVKQELESVGGKEEKDDVSEAGTYTIEKDSSSPEVEQARNDIDRVFGVSGTESEVDVVTPRGNAPTEEAWTPTPESDKFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRM6</accession>
    <name>A0A8J5JRM6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Megakaryocyte-associated tyrosine-protein kinase-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Matk-L2</name>
        <name evidence="5" type="ORF">Hamer_G031575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031855">
        <property type="protein sequence ID" value="KAG7159884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRM6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="147"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7159884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="372" mass="41594" checksum="14764A124B0A1E96" modified="2022-05-25" version="1">MKRLLCCKKPLTDSTPHSPQPTPLPTPTLTTPPLVSLTTPFLVSKSISIPPHTSFPTPRHSPPLTPHPFLPLTTSTRTTLSRMSTSITTLPHCTPSTPLPSSTHTPLISPFPLSLIHSPSFSHPSHCSPHSNSPDYILLSLTEVQIMPVIRRLGEGTFGVVDLIKYNKDLKVLKKMKRVNYATFIEEVKIQRKLDGAGGAPRIHAVCQEDSSVIMDYTGITYDKYINYATTRQKVHTLVKIAEALCEIHQKNIFHNDFKQDNITITVEEKDSTVHIIDFGKATDHEKYINRGKISRYWIAPEFASGGVTSAASDTYSFGQLVRDVRDYITDNRLILKLLDKIVDMTTCEDPLHRVPLTEVVRLMNECLPIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSU4</accession>
    <name>A0A8J5JSU4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Prolyl 4-hydroxylase subunit alpha-2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">P4HA2-L1</name>
        <name evidence="9" type="ORF">Hamer_G002691</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSU4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="8">
        <location>
            <begin position="316"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7163500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="525" mass="58982" checksum="6DEC6003AAA35A5C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JT33</accession>
    <name>A0A8J5JT33_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein 6-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Mfsd6-L3</name>
        <name evidence="8" type="ORF">Hamer_G002977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JT33"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="19"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7163741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="496" mass="55180" checksum="67062C27117CB7D9" modified="2022-05-25" version="1">MLRVYNTDVTELCIVDKSLMADTFGTYKLVMVANMILSVLLHVALLYIPSRPLAPSLTFTCDPEGYHLIWQSCDLCHEHRNHTQVQLTLENCKYQCETPPEEDPRICLGVDDQSHCIALNLTDQILTNGTVVSWLEEDTCSHTWYDLMYEDKVFQGLACPSQCSLECQVNGAPPCNHPDDPTNSYKTFWLYFGIRMVGTFFMSSAFTMCDATTLALLKQHGGQLGIQRLYTLLGFSVGPLLAGFLVDKFSTNSAVPDYSSSLYLGLVFVLLQLPLVSRLHFTVDMAGDNVMRHLAKLMTRMEINVFLVMILLQGSNWGFIESFLFVYLKELGAPTYLLGLTLTVGNIVGAPLMIILDRVVDKLSRPVVFTISFLTYSTIISILAISDPWLAFPFEILEVFTSQLMWLAALSYCPILAPRGLLATMTGLAGSVHYSLGRGAGSLLGGVLISTYGTTSAFRIFEEEEELPEEQVEEKKSMLEKSSTLGSTYEMAAITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTT0</accession>
    <name>A0A8J5JTT0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Mitochondrial 28S ribosomal protein S27-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033882">
        <property type="protein sequence ID" value="KAG7159084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTT0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034913">
        <property type="entry name" value="mS27/PTCD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019266">
        <property type="entry name" value="Ribosomal_mS27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21393">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21393:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10037">
        <property type="entry name" value="MRP-S27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="363" mass="41725" checksum="5E7A365F2397C288" modified="2022-05-25" version="1">MDYRTFLSASYRCEEAWNKRLQLPLIAAIKPSEYFYELDLKYKQEGKVSAIDVDLFVNKIEKSEAVGFEDEIEDLIHRLRRSPETVRTLPSTPHAVLRVLCGSSGINSHAPGRFWLLVDPGTDIGFLLFLRHLGGEPTVKIRVKFLRNPYFDDHFDLKDPNHIVGKTLAWLSPLIGGSVGISCEILGWALYNKWKELDTALDSANKGTDSVAASVLTRVKNFLETCDDLEIKERITSGILRLEASGDKVAELDLGSCINEMVQKAATEAESSDIKAQEDTYLSWEKIRENEFQVQLDEYKKRQLLAEIERKKKDLAEREEVIFFFDNKEKLEMYYPKKLSLRYPKKKPRKVDEGYIPPEVIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JU66</accession>
    <name>A0A8J5JU66_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="12">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Pif1-L1</name>
        <name evidence="12" type="synonym">PIF1</name>
        <name evidence="15" type="ORF">Hamer_G010816</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="12"/>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JU66"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003367">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057437">
        <property type="entry name" value="PIF1/LRR1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF7">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25344">
        <property type="entry name" value="PH_LRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="218"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="12">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="226"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7162153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="675" mass="74784" checksum="6D55E63E4D230658" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUK4</accession>
    <name>A0A8J5JUK4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUK4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="81" mass="9278" checksum="D43694A843C06B90" modified="2022-05-25" version="1">MMATVYLKHHNAKRSKSHSVERNTIHDPMEGSTTHDPQKKSTIHGMENTNAFPHLHDSEKTKVFPHPHNAENINAFPHPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWK5</accession>
    <name>A0A8J5JWK5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Leptin receptor-related protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">leprot-L</name>
        <name evidence="8" type="ORF">Hamer_G008117</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWK5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7162553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="193" mass="21849" checksum="3424A1FC27621F6D" modified="2022-05-25" version="1">MDKSLEQTDRQEQTDRRTDEQTDRQTEQTDRQTEQTDRQTDRQHISPLQVIEGKTGLYILHFELQVIEGKTGLYILHFELQVIDGKTGLYILHFELQVIEALVTLAFSASIGLMFLILACALPEFKEMAYFVTAVLVVSAFGLPIVLARSPVSQPVIQWGACGLVLAGNVVSFLTIWGFFIMADSDDVEYSMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXG2</accession>
    <name>A0A8J5JXG2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aromatic amino acid aminotransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Aro-L</name>
        <name evidence="1" type="ORF">Hamer_G013130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024020">
        <property type="protein sequence ID" value="KAG7165627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXG2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="67" mass="7532" checksum="27A51FD77D51D867" modified="2022-05-25" version="1">MLVKRGVKKNIVLVPGKYFMADSNKPCQYMRAAFSCATADQLMKGFKNLAELIREEIALQNAQIIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYW0</accession>
    <name>A0A8J5JYW0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYW0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="82" mass="9108" checksum="686D1A24FB19560C" modified="2022-05-25" version="1">MVVVMVVVVVLLLLLLVVVVLLLMVVMMVLVVVESPQIRLHGGWSQSKKRTEVKRSAVGGQKSRWMRANESQLEVKSVGVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0S9</accession>
    <name>A0A8J5K0S9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic AMP-inducible protein BP74-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cigA-L</name>
        <name evidence="2" type="ORF">Hamer_G026687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020944">
        <property type="protein sequence ID" value="KAG7168062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0S9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053311">
        <property type="entry name" value="Mucosal_Integrity_Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37999">
        <property type="entry name" value="MUCIN-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37999:SF2">
        <property type="entry name" value="MUCIN-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="881" mass="90477" checksum="77C064AFB09C39C9" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1D2</accession>
    <name>A0A8J5K1D2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SFT2-L</name>
        <name evidence="10" type="ORF">Hamer_G020420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023767">
        <property type="protein sequence ID" value="KAG7165738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1D2"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7165738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="218" mass="23807" checksum="6E9EE595DE3D4669" modified="2022-05-25" version="1">MTDLNRELKEYLSRGDGKSESKVPLLPTTISDIKIPKISSWFTRNGNAANEDEDTASSSSWSSSPQSDPCLPSLGRKQRILGFLACVVMGLICFSLAAMYFPLLVFKARKFALLFTLGSLFSVLSFSFLWGPVNHLKHLFSSERLMFTSIYFISLFGTLYFALSLQSTVLTSIGAIVQVAALLCFVLSNIPGGQTGLKFFSSICSSVVKTTVSKALPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2C4</accession>
    <name>A0A8J5K2C4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxoglutarate-dependent dioxygenase htyE-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">htyE-L1</name>
        <name evidence="4" type="ORF">Hamer_G005244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7166946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2C4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000038">
        <property type="entry name" value="Si:dkey-10o6.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035250922" evidence="2">
        <location>
            <begin position="25"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="243"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7166946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="385" mass="43662" checksum="18C26BBE59FDE039" modified="2022-05-25" version="1">MFLCSYSSLLKIFAFHLCFGFSSCLLDNATIGELKKNKIVMLISWPQPTSVCRLGCVVASLTPEHRYQQKMEGITPGRRIPLVDLGQLGLMHDEEPSQEEWQRVARQLHDAFTDIGFVYLTNHGVSDDQMDHLFKSSATFFNLDEETKIRYQRDPEKQQGYVAVDRETLDTKEMSHELREAYDLSRVDGLFPDVEVPSLRPAAASFYKSCTTLTNRLLIALAHSLGLERNLFTSAHKGLCKDNNLTCLRLLHYPPVPDTIPENTIRCGAHTDYGTITLLFQDNMGGLQVRERGGSWVEAVPVPGTILVNVGDLLQFWTADKFLATEHRVLIPKEELQRKASRHSIAFFINPDNSVLIKPLDGSSSHQPITVKDHLFYKLRKSHNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3A4</accession>
    <name>A0A8J5K3A4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcium-activated chloride channel regulator 1-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Clca1-L10</name>
        <name evidence="3" type="ORF">Hamer_G022695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023675">
        <property type="protein sequence ID" value="KAG7165778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3A4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013642">
        <property type="entry name" value="CLCA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF177">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08434">
        <property type="entry name" value="CLCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium-activated chloride channel N-terminal" evidence="2">
        <location>
            <begin position="84"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7165778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="947" mass="102992" checksum="5F5438FF67BF1B1D" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4N0</accession>
    <name>A0A8J5K4N0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G032051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013927">
        <property type="protein sequence ID" value="KAG7170552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4N0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7170552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="145" mass="16436" checksum="CAE7CBAD77C4E43E" modified="2022-05-25" version="1">MIVPLLHQWTKANALFKPPVINQCRTIEPKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAERTKAEGQGSMQMGSIDYSETKKQIANAKKREQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6M5</accession>
    <name>A0A8J5K6M5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Ataxin-2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Atxn2-L2</name>
        <name evidence="2" type="ORF">Hamer_G018462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7168025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6M5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="263" mass="27788" checksum="DCDC4733A016084E" modified="2022-05-25" version="1">MQVAAATGQPILAPAPMNTQPQAITTVHIPQNMLPQNPQHYQQYPSVPMMLRFPHAGMPVMAAMVPTSMGICHQNPDSQQQSQQHGHQTMYMTQATLPPHQPHPAHTPGPVPQPTQPPTPQNPGGGSGPPNMPNPPSTPGPSPAQSLIYPHMGAQQSLSQHMPQHSPHTAQSPHAPQYPGPGQSAAGTAGGGHHGGPGQQMATQFVVVPPHMMHHAGPPPHSATAHIPSSMAGFTPTSTAAVQHLQSGHHIPYFPKHHPRFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K770</accession>
    <name>A0A8J5K770_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 97-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Cfap97-L</name>
        <name evidence="3" type="ORF">Hamer_G010252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFAP97 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K770"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038791">
        <property type="entry name" value="Cfap97/Hemingway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029488">
        <property type="entry name" value="Hmw/CFAP97"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23035:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23035">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 97-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13879">
        <property type="entry name" value="Hmw_CFAP97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7167848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="509" mass="56167" checksum="9428733665445BDA" modified="2022-05-25" version="1">MVGQPEVVNGSGTAGRGRLADGWLAGDSYNTRVRGRMAHKIGLNDTQYEPDIRGEVDFCFYDDDDVERTKGCKVVSGSTYNSVIGSSSPPGASCLVDSRYRCVEDTSSSGQQASRRSPVEGHQGSEEVSRDEDSGASVSSDSNTPGKVGSASSLEAQQQGASAVMEHVDPNPYSSDEWEESDLSDSDDDHSDSSDDDDPKSQVDRLIERGTLVYMDGENSNLSSETESSDSSDYDDSDSESDITDVSPLISATASPLGLSPVLPRRALGTSPLALHDNRDLSFEYHPENSTYDQGYDSQPHCNGYSHSNSDDSTDMTLLLKAVVELEKKQHRQVNNRTNEFSHHQNSYHHQTSSPITIHPIDASPHHRHLRRTMQHYRRKNMSFTNDEVRRIDRENQILLQKIMCAHNRSKHQSSSNHNSRPVHKPANATVSRRREDEKIRRENMILLRKIQEAKPSRDVTASRSPRQRATHGLRPTSSLPTTPGSCGASARTAPGHVTTPTPRKETAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7P2</accession>
    <name>A0A8J5K7P2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G029687</name>
        <name evidence="7" type="ORF">Hamer_G030128</name>
        <name evidence="1" type="ORF">Hamer_G030820</name>
        <name evidence="5" type="ORF">Hamer_G031346</name>
        <name evidence="3" type="ORF">Hamer_G031433</name>
        <name evidence="2" type="ORF">Hamer_G031487</name>
        <name evidence="6" type="ORF">Hamer_G031493</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022203">
        <property type="protein sequence ID" value="KAG7166675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010018158">
        <property type="protein sequence ID" value="KAG7169158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010012872">
        <property type="protein sequence ID" value="KAG7171155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010010405">
        <property type="protein sequence ID" value="KAG7172842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010008809">
        <property type="protein sequence ID" value="KAG7173824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010006653">
        <property type="protein sequence ID" value="KAG7174830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010000617">
        <property type="protein sequence ID" value="KAG7178238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7P2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7171155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7172842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7173824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7174830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7178238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="61" mass="6973" checksum="40831A9EE108E7A4" modified="2022-05-25" version="1" fragment="single">PSTKTREEGKGSVDRFFQVTEYLKLPQRGMVVFSRAEGLEGRTLTDGQNNREWTTVSHAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K884</accession>
    <name>A0A8J5K884_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G013668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022272">
        <property type="protein sequence ID" value="KAG7166644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K884"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="215" mass="22895" checksum="BA7CA980C843AB21" modified="2022-05-25" version="1">MYPPRKPTHSSRPSPLHPHSPSFLPPQASQAPQLTAIPHYHNPVLSPPHLPSFNHHSSPPQSSSSLIPNTPSRRLLHETLSSPSPHSGYSGSHHHVFSPTIHVSTTPTRSVLSSPIVPRPLPPTTPLHHPPTPPPHPPTPLPNPSVLPPLPTFHPLPLQASPTPAFPSSINSPTLTVLGPLPPTFPPLPLTVTSPHTPLPPLQPSHPSPPTTTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8G6</accession>
    <name>A0A8J5K8G6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G013884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012946">
        <property type="protein sequence ID" value="KAG7171091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8G6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035156813" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="7964" checksum="F823EB2E42422B82" modified="2022-05-25" version="1">MWRALYSNMWSALHATMWRALHPTKCGVPSTPLCGVPSTPLCGVPSTIFCKALYQSFNSTLDTELSRDSESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KG38</accession>
    <name>A0A8J5KG38_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polypeptide N-acetylgalactosaminyltransferase 9-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Pgant9-L2</name>
        <name evidence="2" type="ORF">Hamer_G018543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012106">
        <property type="protein sequence ID" value="KAG7171431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KG38"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF131">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="9825" checksum="FF378EA6463BB3F1" modified="2022-05-25" version="1">MPGWLEPLLVRIAVEPQTVVCPVIDVISDDSFEYHYRDSSGVNVGGFDWNLQVYSIPIWQQLTYSKRFISTLLSDFQVLDIYNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KGJ0</accession>
    <name>A0A8J5KGJ0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CD109 antigen-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Cd109-L4</name>
        <name evidence="3" type="ORF">Hamer_G011601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KGJ0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF171">
        <property type="entry name" value="PREGNANCY ZONE PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-macroglobulin-like TED" evidence="2">
        <location>
            <begin position="30"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin-like TED" evidence="2">
        <location>
            <begin position="151"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7168924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="206" mass="23127" checksum="2E6682B9A9AA99FB" modified="2022-05-25" version="1" fragment="single">FETGEDSLEAWELETPSAIVEGSERAWVTAVGDLLALTLENLGHLIRMPYGCGEQNMVNFAPNIYIMQYLEASHQTTPESTKKLLNFMKTGYQRELLYRRNDGSYSAFGNADNSGSTWLTAFVLKPGMTPVVPQFVWLPSAYRPTPPRTPTPWPSRKSKAVAVETAGYSVMTMMTLDPKKYEQQARKVVKWITAQRNGQGGFYSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KHF3</accession>
    <name>A0A8J5KHF3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G018845</name>
        <name evidence="2" type="ORF">Hamer_G029630</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018499">
        <property type="protein sequence ID" value="KAG7169074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010017228">
        <property type="protein sequence ID" value="KAG7169352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KHF3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="86" mass="9911" checksum="5A266736F8DFA8CD" modified="2022-05-25" version="1" fragment="single">MVFTSEQVMNSKQRKVVEEGSEGWQTGKREVVEWGREVWKTGKRKVVEEGSEGWQTGKREVVEGGREVWKTGKRKVVEEGSKGWQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KIK9</accession>
    <name>A0A8J5KIK9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G013910</name>
        <name evidence="3" type="ORF">Hamer_G013923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012946">
        <property type="protein sequence ID" value="KAG7171108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010012946">
        <property type="protein sequence ID" value="KAG7171118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KIK9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7171118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="74" mass="8420" checksum="D00D4A73BA4EF091" modified="2022-05-25" version="1">MHSAGEKDVLYENRSGGTTISSDLTNLGRFKRDDRVVPDFPTIYQALFNKPQVPTSNHMFLVKLPKQPTRKEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KLJ5</accession>
    <name>A0A8J5KLJ5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemicentin-2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Hmcn2-L2</name>
        <name evidence="7" type="ORF">Hamer_G012304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="7">Heart &amp; testis</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KLJ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035217862" evidence="5">
        <location>
            <begin position="23"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="164"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="277"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="370"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="484"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="583"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7170079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="703" mass="77634" checksum="673757B32D5D0E15" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MGT8</accession>
    <name>A0A8J5MGT8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative olfactory enriched transcipt 01.1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G010711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MGT8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035273033" evidence="2">
        <location>
            <begin position="20"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7153398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="270" mass="30115" checksum="BE50E37205C753C5" modified="2022-05-25" version="1">MLRLLLCYVLCLSLTCTAAQNYDYCLEKDGQNSCASVEVNLDDDTISYTMEEDDHFQASQTVEFYEEGVAATKVLSGDNEGGCFLRGLANTINEKMEFLETNNNAVTTITKNTEVATMSLDGANFPQLSKTITQFCGDHISGYLINESGDPITDSDGDYADSNEEGDGNEEGDGNEEGDGNVEDSKCFFFSTIPKCFTNTVVSSDKRGIHPRHSKGFTIFRRPGCVRPTRLPGFPVRPRPFVYIRPHKPRPFGFRLPGFRPFRNRFQTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJK0</accession>
    <name>A0A8J5MJK0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G-protein coupled receptor Mth-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mth-L1</name>
        <name evidence="6" type="ORF">Hamer_G017661</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 2 family. Mth subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046276">
        <property type="protein sequence ID" value="KAG7153848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJK0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.180.11">
        <property type="entry name" value="Methuselah ectodomain, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052808">
        <property type="entry name" value="GPCR_Mth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023311">
        <property type="entry name" value="Methusela_ecto_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036272">
        <property type="entry name" value="Methuselah_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63877">
        <property type="entry name" value="Methuselah ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035190309" evidence="5">
        <location>
            <begin position="25"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7153848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="538" mass="60057" checksum="389507EA543F2608" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK28</accession>
    <name>A0A8J5MK28_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044465">
        <property type="protein sequence ID" value="KAG7154341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MK28"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39313">
        <property type="entry name" value="IM:7138239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39313:SF1">
        <property type="entry name" value="IM:7138239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="339" mass="37354" checksum="0B4D427AFAAA824C" modified="2022-05-25" version="1">MVGAPNTGRWTAIGTEATYKDDVTRPEVSHEEAGGALDEVLSVGSVSQYLSEARRLVKAEEDLDVTLEEGDHTTCCQREPNMNHIGVSGEEIVMDVGHCPRRCGKKKQLKRNEFERLLLDNPDMDPRMLFLLHSGQRRSQQSCPGEEEEMCAASAWRVERLVTTEGVVSVTVTEACECQPRPHSCRHHPRPVTLHKGTPLQTTVDLGHCQGHCYHDLGCKAIKSRTVSVEGPNGAECVSVVEECGCQSSCYRASLYQHVYNYTTEDDPSVQVIDVGTCTGECDIVQEDQCVLRETSGGCMMSLVKRNSRCSPSSTKDMEIHQADGSIRSLTTITHCGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ML48</accession>
    <name>A0A8J5ML48_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G025878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042425">
        <property type="protein sequence ID" value="KAG7155240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ML48"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="283" mass="32817" checksum="12B3BA22C274AE68" modified="2022-05-25" version="1">MEVSEATIDKTNNELLFTQLRSGRSYDTTPLYSEPTSDSVLTSPDQCTSNLPALPLTSKPITTNMTNPVTQATNVWKILPQHDRIRDFTGEEPHYNVFAFLLAREDMMRHNNVQDDEACKASNLMNASAFTRSTYDEFKRNFIRFFDQGRGDSHLTWVFRMVNRTLTRIQTQDLFMAQSMAGQAYDDAKTHFSASDWWENNRTMSEENVYRLIEYIQFIFLIQEIEFKEAQKENYPQSDELTDYAEKIIQRTPYTPCARTIALVATTPVEVKKKQVPSLNKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNQ0</accession>
    <name>A0A8J5MNQ0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-directed DNA polymerase from mobile element jockey-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G014879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035946">
        <property type="protein sequence ID" value="KAG7158000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNQ0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF2">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="296"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="590" mass="66645" checksum="FA5B5FAD4B50BF7B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MP02</accession>
    <name>A0A8J5MP02_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein KTI12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kti12-L</name>
        <name evidence="5" type="ORF">Hamer_G019480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035076">
        <property type="protein sequence ID" value="KAG7158464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MP02"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7158464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="310" mass="35318" checksum="5156502FB974FC54" modified="2022-05-25" version="1" fragment="single">CNQSLHRYLSRNFEEETTHPFLLSPFLSGLCKVNKHHLLLLVLGGLWDMPLVIISGFPSSGKTRRTLEIKNYFESEKSKKVTVVSENELLVGKNEIFSDSKQEKEIRGTLKGDAIRLLNKDDIVILDAGNYIKGFRYELYCASKQIKTTQCLVQCVAPIEQAWTWNQMRPENERYTREVFDGLVMRYETPNSKDAPPCDPMHDALYLCKPPPPNQSTQTQPLSSTNFLFELDRTTQDVTSCIMSAQRTLVPGDSIKVPGVEESISLGRKVTLAEVTRARRQFISYTKMHPVEDTSKLMSLFIRYLNSTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQM4</accession>
    <name>A0A8J5MQM4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G012687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQM4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="96" mass="10949" checksum="66D83009CE30BB34" modified="2022-05-25" version="1">MSSEDIFDFVDALEQQTYAAGLLGSVLLNCESELDPRLQNQIVKLLATIRDWPKWDPSDEDKIETKLAAIHTKSRYILQRLNIPSKVIDRSVDGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQN5</accession>
    <name>A0A8J5MQN5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Ugt8-L2</name>
        <name evidence="7" type="ORF">Hamer_G021645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031456">
        <property type="protein sequence ID" value="KAG7160268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQN5"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF27">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035293257" evidence="6">
        <location>
            <begin position="26"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7160268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="536" mass="59726" checksum="F7DD0FD1516DF36A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQW2</accession>
    <name>A0A8J5MQW2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen alpha-1(XXVII) chain-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Col27a1-L2</name>
        <name evidence="3" type="ORF">Hamer_G017424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7159982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQW2"/>
    <dbReference type="OrthoDB" id="6380629at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035293258" evidence="2">
        <location>
            <begin position="18"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="248" mass="25620" checksum="3AF4ABBAAF9CBAFB" modified="2022-05-25" version="1">MMSVLWIGALLLVVVSGRVTFAHVTTPIVDGGVVGEEGGTDGEEEGGGEERMARWRSLKEQLLSLKGDPDLEDDSPHTRHPRTLFSAGYTGCSCSDLAALAAQISLFEEEVKSIGEMENKLSIISTAIKQLGIWVDAGIRGPQGHEGIPGTQGPPGLPGDDGDEGPTTIRTRQGIPGPPGHPGPSGVRGPKGNTGDCIKGNKGTQGKRGNPGVGFQGLRGLPGPSGLVGNPAPDLKTLRSAAQAKRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQY1</accession>
    <name>A0A8J5MQY1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G030389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031220">
        <property type="protein sequence ID" value="KAG7160628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQY1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7160628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="132" mass="15451" checksum="63985658E4FC8B29" modified="2022-05-25" version="1" fragment="single">MAETSTNNTVRMDGFQTGQSSASDTSQNCEQTSYYEKPNSDLTPNIGPSRRTRKQKMDQLCDEDILLAQMQMQQAQLSIENLRLERKTLQERYQQQREAHEWQRAQHEANLNLAMLQIKFWEKKTGYGDMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR34</accession>
    <name>A0A8J5MR34_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Inositol oxygenase</fullName>
            <ecNumber evidence="4 13">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 13">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MIOX-L</name>
        <name evidence="15" type="ORF">Hamer_G007596</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12 13">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 13"/>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR34"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7160838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="160" mass="18555" checksum="6F76F828D136260E" modified="2022-05-25" version="1">MVVGSTDSSWEKKVLLIDPSLVFRPEEVVKKSGWGFRHFQSSDDPKFEMVKETYMKMHTEQCVDYVKRKHNYWGKFDKFEATVLGLEKLNNLIDKSDPDVDIPNIVHAFQTAERIRQAHPKNWFHLTGLIHDLGKVRGRGRGEGKGGEEKRQKEREEGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTD3</accession>
    <name>A0A8J5MTD3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027321">
        <property type="protein sequence ID" value="KAG7162711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTD3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="18" mass="1989" checksum="8A74355B63F87AA1" modified="2022-05-25" version="1" fragment="single">MEVGVSYQHPGWSGIGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU35</accession>
    <name>A0A8J5MU35_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Coiled-coil domain-containing protein 103-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Ccdc103-L</name>
        <name evidence="14" type="ORF">Hamer_G002879</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Dynein-attachment factor required for cilia motility.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DNAAF19/PR46b family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU35"/>
    <dbReference type="OrthoDB" id="447931at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036157">
        <property type="term" value="C:outer dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003351">
        <property type="term" value="P:epithelial cilium movement involved in extracellular fluid movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042422">
        <property type="entry name" value="CC103"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031733">
        <property type="entry name" value="Dynein_attach_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28572">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28572:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15867">
        <property type="entry name" value="Dynein_attach_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein attachment factor N-terminal" evidence="13">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="12">
        <location>
            <begin position="109"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF15867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7163656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="238" mass="26320" checksum="54684A0ADAE75409" modified="2022-05-25" version="1">MACGGWEGSVDANQLEARLRAGLEADRRYTAENAAKLRAIHSAPTYDEFRQLVLGAHLKPLDRNDKSKVRPSIWNSLASSATKKSSKPPPQDTENSVYPTDVQYDVNNPPSTTEGLVQLWERLDLAERLELLRNLSPQATERLAGGLVAGGLLGDAITTLLAFTPTVSDVVMVVNMLQALTLAKRFTLSVTLVCGEERWAWGRLLEKLQLALSERPQDLAELNVTEWTLAQLKLKFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVF7</accession>
    <name>A0A8J5MVF7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVF7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="65" mass="7123" checksum="6DD4F594EA2950E9" modified="2022-05-25" version="1" fragment="single">LVLLLVAAATALPAPAPGPEAGAEPDPQLFYSSLGYSPLWYNYPTFFPYTQYYHIPYVVAKKSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVQ3</accession>
    <name>A0A8J5MVQ3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase rififylin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Rffl-L</name>
        <name evidence="6" type="ORF">Hamer_G011043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVQ3"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16500">
        <property type="entry name" value="RING-HC_CARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000110">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF34 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051728">
        <property type="entry name" value="RING-FYVE_E3_ubiquitin-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055111">
        <property type="entry name" value="RNF34_RFFL_HeH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057299">
        <property type="entry name" value="RNF34_RFFL_SAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879">
        <property type="entry name" value="CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879:SF15">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RIFIFYLIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22968">
        <property type="entry name" value="RNF34L-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23632">
        <property type="entry name" value="SAP_RNF34_RFFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="484"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7166220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="531" mass="57949" checksum="666D2F29B6CA1E0F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWW9</accession>
    <name>A0A8J5MWW9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tigger transposable element-derived protein 1-like 192</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TIGD1-L192</name>
        <name evidence="2" type="ORF">Hamer_G013681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022272">
        <property type="protein sequence ID" value="KAG7166656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWW9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1197" mass="133687" checksum="8C971C26BA03BFA2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYE6</accession>
    <name>A0A8J5MYE6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">sulfite oxidase</fullName>
            <ecNumber evidence="6">1.8.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Hamer_G022734</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Energy metabolism; sulfur metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.1" evidence="6"/>
    <dbReference type="EMBL" id="JAHLQT010018399">
        <property type="protein sequence ID" value="KAG7169115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYE6"/>
    <dbReference type="UniPathway" id="UPA00096"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02111">
        <property type="entry name" value="eukary_SO_Moco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="88"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7169115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="533" mass="59469" checksum="E2D42FF52C83D855" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYJ3</accession>
    <name>A0A8J5MYJ3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-beta-hydroxybutyrate dehydrogenase-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Bdh1-L2</name>
        <name evidence="3" type="ORF">Hamer_G002634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYJ3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7168548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="276" mass="30309" checksum="1A52BC686C1E167D" modified="2022-05-25" version="1" fragment="single">MLSARYAHQYKTTYKHQQPTGVVFTLSCRTRMIWTYDKTEEVVFWGCVSVLLAALLHVLGLCSWWTVFPTTWLLSGGASLILSSLTVSSSGKAVLVTGCDTGFGNSFALILDRLGFRVFAGCLHAGGEGANHLRREGSSRLHVLQMDVTNQEQLDKAAQEVKHLLPEGEVLWSLVNNAGLSAFGEVEWVPLNTYRKVAEVNVFGVISVTKTFLPLLRRARGRVVNMSSVAGTIGRGVMSPYNLTKFAIEGFSDCLRQEMMAWGVSVILVEPSNFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYY0</accession>
    <name>A0A8J5MYY0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016338">
        <property type="protein sequence ID" value="KAG7169490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYY0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="323" mass="37361" checksum="69EE698E82852C34" modified="2022-05-25" version="1" fragment="single">ESEVAKDSINRYGLELVQSFEALHAKIPEVEIVGYHRKFYMRFTDKTKIDRARKKHDERLAHISELDKELINDMIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZA5</accession>
    <name>A0A8J5MZA5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U-scoloptoxin(01)-Er1a-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G011669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZA5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF42">
        <property type="entry name" value="FI18455P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7168979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="144" mass="14522" checksum="6B545668B8EA2907" modified="2022-05-25" version="1">MGGLPRTVLVFDYPILASVPNTGFSCIGQVPGYYADTSPDAGCQVFHICQVGGRKTSFLCPNGTIFNQQFFVCDWWFNFDCTTADQFYDLNNEIGRVPSRGGGGGGGGSGGGGGGSGGGGGGGGSYAGGGGVRPPSSQYGAPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZI0</accession>
    <name>A0A8J5MZI0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Coiled-coil domain containing 32-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G021884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014991">
        <property type="protein sequence ID" value="KAG7169880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZI0"/>
    <dbReference type="OrthoDB" id="5982503at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028039">
        <property type="entry name" value="CCDC32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31800">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31800:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14989">
        <property type="entry name" value="CCDC32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="225" mass="24126" checksum="CCEA5D3A049B428B" modified="2022-05-25" version="1">MQGQNEDLWGPATSLSATSPAESLDFEDAFSPPQDTTSGGNTQQQSADGDYVPLDDSSQYLAGLERKLACVQGRTTAHRQTESRRLIDALATSRDDHAHHLLNNTNNIGADSDVLEPDNDRSGALTAATVDPQGALGAMLRRVAPDKIALAPEELCRLLEADILSKVHDALEEEAQAPHPPTQHSKNTSEEDQSCEGVRSVDGSTENNTIKLADQKDPSSDEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N030</accession>
    <name>A0A8J5N030_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G031419</name>
        <name evidence="2" type="ORF">Hamer_G031762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026226">
        <property type="protein sequence ID" value="KAG7163805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010015346">
        <property type="protein sequence ID" value="KAG7169821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N030"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7169821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="146" mass="15742" checksum="E31E5C10C7266735" modified="2022-05-25" version="1">MGCLHSPVVSVGNPPTHVADDGHISVTMESRCASSPCDDVTEPTPSTGYGARSEIIGRKRLPLKRKILTGYHSSSESEESVDEPKSRQHREVGCRSRTQPITSRRKPTHSASTLLPSTPTPAALPTRDDEAGDERGTVSEVREGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0G5</accession>
    <name>A0A8J5N0G5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial GTPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mtg1-L</name>
        <name evidence="11" type="ORF">Hamer_G012204</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7169987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0G5"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000004">
        <property type="entry name" value="Mitochondrial GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000876">
        <property type="entry name" value="Mitochondrial GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CP-type G" evidence="10">
        <location>
            <begin position="35"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7169987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="329" mass="37203" checksum="3F9E7F85F2F27AF2" modified="2022-05-25" version="1">MAVPVVRHGLRMRKFFNIKNQDVAQWFPGHMAKGLNQMQRKLKSVDCIIEVHDARIPVSGRNSLFEKRLGLSSLKPHILILNKIDLADLRHRNKIESYYESQGVKNIIFANCKKPDSRGIKSIIPTVSELVQNAERFNRSEEKEYQMMVIGIPNVGKSSLINALRAKHTRKSKATQVGGLPGITRSVLERIKVCHHPKVYLLDTPGVLSPRIPDVETGLKLALVATIKDHLVGEDIMADYLLYRLNSQGNHSYVSYLGIDEPTDTIQQLLVSAAIKNNWMVKIRDHRGIQTVPNIMLSATKFIKGFRTGQFGTLLLDDTPLMLEKERNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0G6</accession>
    <name>A0A8J5N0G6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DM4/DM12 family-like protein 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G021176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013493">
        <property type="protein sequence ID" value="KAG7170798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0G6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41158">
        <property type="entry name" value="AGAP010294-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41158:SF2">
        <property type="entry name" value="AGAP010294-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="668" mass="72175" checksum="0B2BFC0ED59D3A5E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N263</accession>
    <name>A0A8J5N263_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-ureidopropionase</fullName>
            <ecNumber evidence="6">3.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-carbamoyl-beta-alanine amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">UPB1-L</name>
        <name evidence="10" type="ORF">Hamer_G000685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-(carbamoylamino)-2-methylpropanoate + H2O + 2 H(+) = (R)-3-amino-2-methylpropanoate + NH4(+) + CO2</text>
            <dbReference type="Rhea" id="RHEA:37339"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57731"/>
            <dbReference type="ChEBI" id="CHEBI:74414"/>
            <dbReference type="EC" id="3.5.1.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-(carbamoylamino)propanoate + H2O + 2 H(+) = beta-alanine + NH4(+) + CO2</text>
            <dbReference type="Rhea" id="RHEA:11184"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="3.5.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; beta-alanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the carbon-nitrogen hydrolase superfamily. BUP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.6" evidence="6"/>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N263"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003837">
        <property type="term" value="F:beta-ureidopropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033396">
        <property type="term" value="P:beta-alanine biosynthetic process via 3-ureidopropionate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000008">
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        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
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        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF2">
        <property type="entry name" value="BETA-UREIDOPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CN_HYDROLASE"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="36"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00050552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061249"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00066985"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7171774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="350" mass="39089" checksum="9025835FFFC57DBA" modified="2022-05-25" version="1">MAGEMVSLEQCLEKYVPERELKEITRILYGRELPIVRVGVIQNSIAAETTAPVSEQRAALHEKITHMTEAAALCGVNILCYQEAWTMPFAFCTREKQPWCEFAESAESGPTTQLCQELARKHNMVIVSPILERDSIHGDTLWNTAVVVSNTGYYLGKSRKNHIPRVGDFNESTYYMEGDTGHVVFQTQFGRIAVNICYGRHHPQNWMMYGINGAEIVFNPSATVGGLSEPMWGIEARNAAIANSYFTCAINRVGTETFPNEFTSADGKPAHKDFGHFYGSSYVAAPDGSRTPSLSRTHDGLLVCDLDLNLCRQVKDRWGFRMTQRLDLYAASLSAAIQPEYQPPVVKDMC</sequence>
</entry>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">Hamer_G001122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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            <taxon>Homarus</taxon>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="142" mass="15924" checksum="6548B946AC435854" modified="2022-05-25" version="1">MGRHMALKTMTRQTHSVNYLVDGADVRDDRRSAQTARAYPSLYDPYVVLSGRSSASAPIRPLDPLCDPVHLGYIGRLRSSDQPLPGNYYVIGVILDTSSKPYWKNHFVIGEAMSFSPAVRHHDELYGPTYQNLKISLKSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2Q9</accession>
    <name>A0A8J5N2Q9_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Hamer_G001020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2Q9"/>
    <dbReference type="Proteomes" id="UP000747542">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="79" mass="9482" checksum="1D5645C17F3646CE" modified="2022-05-25" version="1">MMCNRWNDVFHEVQVEVGEKWKHHKQKVSGEMTEVREELKKVSSRMEVLENCLTARYQPRFSDSYNCDVRETSFMHAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2T0</accession>
    <name>A0A8J5N2T0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Tyrosine-protein phosphatase non-receptor type 23-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ptpn23-L2</name>
        <name evidence="2" type="ORF">Hamer_G009522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7172181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="631" mass="69875" checksum="CF241B44654B6206" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2V1</accession>
    <name>A0A8J5N2V1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Nephropoidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2V1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035189018" evidence="1">
        <location>
            <begin position="33"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="143" mass="13778" checksum="F46E2D50B1B88A58" modified="2022-05-25" version="1">MESHSVSVYCIRNMMVVVVVVLMAGLLATVLASPVATPSGGGSYGHRRSGYGGYGGGYGGYGGYGGGYGGGYGGYGGYGGYGGGYGGYGSGYGGFGRGYGGYGGGYGGAYGGYGGGYGGYRSSYGGGHGRGYGGYGGGYGYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2V4</accession>
    <name>A0A8J5N2V4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signaling mucin HKR1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">HKR1-L1</name>
        <name evidence="2" type="ORF">Hamer_G001152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7172146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="69"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="814" mass="86679" checksum="EDECDB8A09D86FC0" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N523</accession>
    <name>A0A8J5N523_HOMAM</name>
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        <submittedName>
            <fullName evidence="9">Myosin light chain kinase family member 4-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="primary">MYLK4-L</name>
        <name evidence="9" type="ORF">Hamer_G020139</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009549">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Myosin light chain kinase isoform-III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF20">
        <property type="entry name" value="MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE"/>
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    </dbReference>
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        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
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    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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            <begin position="4"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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    </feature>
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        </location>
    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="1304"/>
        </location>
    </feature>
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            <end position="1464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="302"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="530"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="708"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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            <end position="723"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <end position="752"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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            <end position="770"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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    </feature>
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        <location>
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    <feature type="non-terminal residue" evidence="9">
        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7173516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1464" mass="165302" checksum="14883BF034CB3338" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5C6</accession>
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        <submittedName>
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    </protein>
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        <name evidence="5" type="ORF">Hamer_G017943</name>
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        <name type="scientific">Homarus americanus</name>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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        <property type="entry name" value="EF_hand_dom"/>
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        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
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            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7173660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="350" mass="39929" checksum="2E4D02A056A7C51A" modified="2022-05-25" version="1">MAKASFYDPTRDFSCLDGSGTIPFSYVNDEYCDCQDGRFFYCTNAGHTPLNIPSSRVNDGVCDCCDASDEYASNANCVDTCRELGRAAREEAAKQREERLKGYQLRQSMIEDGRKKKKEAEGKIEELKKEKEEADAVRSEKEEIKKAAEEPEKLALEENQAFEAEKKAEAEAEEKRKDLAEARTAFVILDNNGDGILTVGELQSRQTFDTNRDGQVSMEEAKFYLKQEDSMTLEQFVTSGWLMVRPVYTMDKGMFIPPSTTPNPLDESLTPPPMFDEEDNYDAGEEEEEPEDFDSNLDPEDDFEDEAEDDYDHEDNAEDVAQENEQKEEEEPKYDEETQKLVDGQLLNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6W6</accession>
    <name>A0A8J5N6W6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6W6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="414" mass="45937" checksum="5FD0F502529C8B49" modified="2022-05-25" version="1">MWHLINKVAKKNPSSALHHSPAEYAQDLVDTWSEQSQAHNLTEHIQEALSCQSNLRTLRLKAALLKVDEEDTVEITEEELRHAIIRGSMESTRSKTEVWLIGQHITEITGAQLPSRGDVLRLFFHGHNEHKKTVNDSASEVAASVISFWNKARIPTITEKSIGRKVVDLFLMWKGLKKNCTRTTDTQRKKEETFCDELEDLFDVAHPKAMQLLTIKEDRAFLAAQREKGRRGVMAGVDKKIACSIKRREESKSKQSLQQNQASSALEYDELGSSSETESQSSSSSSTSSLAISPVVSSSNRKRATLKVITPELSSTLDRTGISHRSALRIVSATAASLVAVPHFSGTATTSWPLSWYYTLVLLVPFPPSPTRTTTSWPLWCHYAMALVVVHAPGHRTMLLNVNISIQGSSAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N736</accession>
    <name>A0A8J5N736_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Splicing factor 3A subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Sf3A2-L1</name>
        <name evidence="18" type="ORF">Hamer_G003281</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins. Part of the SF3A subcomplex of the 17S U2 SnRNP complex which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62 and SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the mature 17S U2 small nuclear ribonucleoprotein complex (17S U2 snRNP). Identified in the spliceosome 'E' complex, a precursor of the spliceosome 'A' complex. Identified in the spliceosome 'A' and 'B' complexes. Identified in the spliceosome 'C' complex. Interacts with HTATSF1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N736"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001216">
        <property type="entry name" value="Splicing factor 3A subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="17">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="217"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="218"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7174342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="348" mass="38000" checksum="1B74268AE3DFDE0F" modified="2022-05-25" version="1">MDFQHRAGGKTGGGGQASWSESNRDRRERLRQLALETIDLNKDPYFMKNHLGSYECKLCLTLHNNEGSYLAHTQGKKHQTNLARRAAKEAKESPAQPAPEKPRVEMKKFVKIGRPGYRVTKQRDPETGQQSLLFQIDYPEIADNVAPRHRFMSAYEQKVEPPDRKWQYLLFAAEPYETIAFKVPSREVDKSWTTWNKETKQFFLQFAFKIDPKAKMVPPAPPPLSGVGPPGPPGPPGMPPPPGLPPRPPMMPPGPPPPGMPPPPGMPPPPPIRPPMRPMMPPPPGPPGHHGPHGPLRPPPGPPGMGPPPGMRGPPPPPGGPPPPPPPFNPVPPPPPSTGVPPPPPPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7Z5</accession>
    <name>A0A8J5N7Z5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7Z5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="70" mass="8166" checksum="7C23A7BB20D7A742" modified="2022-05-25" version="1">MQGTAPPKRHNYKWNRLHALETDIRQEEELAIQEITCQETSSPLQQITRVRTTNTDRQQTHDHSARATTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8L8</accession>
    <name>A0A8J5N8L8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cell cycle checkpoint control protein RAD9A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DNA repair exonuclease rad9 homolog A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Rad9a-L</name>
        <name evidence="13" type="ORF">Hamer_G001216</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'-&gt;5' double stranded DNA exonuclease activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8L8"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000005">
        <property type="entry name" value="Cell cycle checkpoint control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="273"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7175196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="449" mass="49283" checksum="91829C3E7850F309" modified="2022-05-25" version="1">MKCTIPGSNIKVFGRAIHSLARIGEELYVEPYPTGVYFRAVNSSRSAFASFHFGSRFFAHYNDGSGGQQSAAGEEAVKCKVSMKACLNVFKSLVTLVRSVERSKLFLDGEEAKLGIQFICKYGIVKSYNLPFIECETLHAAYDKTSCTNYIKSQAQVLSKAVINFQSNQEEVTLCVSSNKIVIRTFVDDVPDPGKAIHTELTLEAGEFDSYNIPDDCEVTFCLKELRAILAFAEPINLSVASYFTEPGNPIIFAVDNHPMFESTFVLATMAPKSNTQASRNKATDKHTSKPGNGQRSSASPSCSQAASWMKTPMPSTSGLKQANSSTVRRSEQITNISNRFDESRARLSSPHNSSTRGNHNPQLGNGSARHLSTQPVTHTNNVNASQLEISLPNLDVVNKVTEEEDVIPGTPPSKRAKFFFRRCFESTFDPTTVPGHDRILASDSDDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA10</accession>
    <name>A0A8J5NA10_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription factor IIIB 50 kDa subunit-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Brf2-L2</name>
        <name evidence="1" type="ORF">Hamer_G009827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA10"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158791">
        <property type="entry name" value="MgtE N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="214" mass="22067" checksum="C5B8DA0F9996F238" modified="2022-05-25" version="1">MLTLAQAGVVLTKLTLAQAGAVLTQLTLAQAGVVLTKLTLAQARAVLTQLTLAQAGVVLTQLTLAQAGVVLTKLTLAQAGAVLTQLTLAQAGVVLTKLTLAQARAVLTQLTLAQAGVVLTQLTLAQAGVVLTKLTLAQAGVVLTQLILAQAGAVLTQLTLAQAGVVLTQLTLAHHFEKVELRVAELKIINLLHRTGVWIGRKQCDPGDTLHISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA79</accession>
    <name>A0A8J5NA79_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TBC1 domain family member 19-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TBC1D19-L</name>
        <name evidence="2" type="ORF">Hamer_G009736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA79"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042507">
        <property type="entry name" value="TBC1D19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16110">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16110:SF1">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="62"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="225" mass="25494" checksum="D1150DF1DA77373F" modified="2022-05-25" version="1">MKDLQLTASNDDQYFVFEDILFQVKQSPSDVASPPLAAARGNTPSPDSLVAYPPCGVIPFHGFTMFAAPLSCLYEDPVHLYFTFREMYCRYWYRLHIVTSHPQGAAALALQFELLLQSCETRLWQHCAAMSIQLLPIVFKWMVRGFSGYLIPDQLFHLWDVVLAWESVEVLPVLALAIVSFRRENLMDVTSQQAAESVLADITAIRVIPLLKLALAADRNRDRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA83</accession>
    <name>A0A8J5NA83_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein 3-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Msantd3-L3</name>
        <name evidence="2" type="ORF">Hamer_G020690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004953">
        <property type="protein sequence ID" value="KAG7175643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA83"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="194" mass="22344" checksum="BB22A2478E4ADDE7" modified="2022-05-25" version="1">MRQITEQYNSSANVQRRTPLQLRTCWKNMKVKARKYIDSERRPQVKTGRGPPNFQPASKAVEDTLAVLPPKMYQPVDSDIGDNEPLAQAEESLGAIQDDAVIIQNSEIVEDDMGEILNGREGTSSNLYNSRPHSSLSTENEVSRPYSGCSNRHETYRHQYQTPKKVAARLKSTGWSYFFRKKNTRRNLFFWMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBR3</accession>
    <name>A0A8J5NBR3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Rbp1-L</name>
        <name evidence="4" type="ORF">Hamer_G020897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001665">
        <property type="protein sequence ID" value="KAG7177831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBR3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12373">
        <property type="entry name" value="RRM_SRSF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000078">
        <property type="entry name" value="serine/arginine-rich splicing factor 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7177831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="221" mass="24836" checksum="D51B3D65B599A2FD" modified="2022-05-25" version="1">MEIFGSQLMQVKRMRMDCKVYVGNLGNNAAKHELESAFTKYGPLVNVWVARNPPGFAFVEFEDPRDAEDAVRALDGTRLCGVRVRVEMSTGRSRRDRYRSPSRRGPALPEGLAVLVPGHQDAHGPAPPGLFHDHQGMMITADEVTLQTSEDVPDHDHRKVCTHQRILDTSEDEDSSLPSERLGNLYVEVAVLEELMKKLPVTEHIFSPCLAMRNFMITLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NC03</accession>
    <name>A0A8J5NC03_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Centrosomal protein of 41 kDa-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Cep41-L</name>
        <name evidence="4" type="ORF">Hamer_G015463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NC03"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051889">
        <property type="entry name" value="CEP41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44390">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 41 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44390:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 41 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="138"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7176651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="315" mass="35565" checksum="D732C07C4DFCAB1E" modified="2022-05-25" version="1">MHSRKFIVKGCQSVNTLKKYSVSDRGILDKRVKSNPRYTGVRSRTDTGFNTQRRQELEHEIRKYYKVRNDEVFRRISLADMLQLMVAHAEDVEAIECITCESEVDNNEAEVPLKYRDEVDCVVHKMDQLEVDSKTNIPQCPYVMIDVRPQGEFKTCHLATAVSHPHSRLSRAVGWECPELLIYKNHPEFIIIVYDEGEDLAPEVAATLQHRGYGNVFMLSGGLRLAKDKFGFPLVTENTAGSLSFQVVDAISQQLSNTVLPPLSMADASEWWAAASKLPNSATDSGITHTTPSTGRQTTRSQIKDKDGQPARPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NE02</accession>
    <name>A0A8J5NE02_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NE02"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="80" mass="8758" checksum="6369FAB1654AAF7E" modified="2022-05-25" version="1">MARVSAEEEDTNDLTNTQDTERQTASVVLYLGHRYEDEMDAEVAEGVNTAASCHDSTLKMLPRLSAALLADYAFFVSLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T2S9</accession>
    <name>A0A8J5T2S9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G009562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T2S9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="81" mass="8495" checksum="D8421A4F3282C44A" modified="2022-05-25" version="1">MLVGYSDDTIHLSPSFSSLSNSPLERDVGMGNSCLAASTSVPLCVGNCFTGPSSPSAVDPQQVVVPCSSPDYLHEIITFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T3S1</accession>
    <name>A0A8J5T3S1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calmodulin-binding transcription activator 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Camta1-L</name>
        <name evidence="12" type="ORF">Hamer_G006845</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">May interact with calmodulin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CAMTA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000065">
        <property type="entry name" value="Calmodulin-binding transcription activator (Camta), drome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000089">
        <property type="entry name" value="calmodulin-binding transcription activator 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335:SF1">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="IPT/TIG" evidence="11">
        <location>
            <begin position="403"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="143"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="353"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="706"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="762"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1169"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="706"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="725"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1182"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7172634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1323" mass="147333" checksum="ACC273C2BD938825" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TDT0</accession>
    <name>A0A8J5TDT0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TDT0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="158" mass="14142" checksum="13AB25FE897E36A8" modified="2022-05-25" version="1">MEAVAQAAQAAPAAPAAPAAPVAPAVPVAAPRRNIKWAAAAMVDMVVVAQRWYGGYGGVGGYGGGGSSGGGGYGGYGGGYGGGYGGGGFSGGGGYGGGYGGGYGGGGSSGAVVWVIAMVVGYGGGYGGGYGGGYSGGNGGGYGGGYGSGSSSSGGYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TEL7</accession>
    <name>A0A8J5TEL7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007918">
        <property type="protein sequence ID" value="KAG7174120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TEL7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="8083" checksum="208DA37978F37451" modified="2022-05-25" version="1">MDSAPGDNRILPQDKVGFRPRIGQDSAPEYTRILPKETLEYRSRKRRLKESAPEGGRILLQNMVGFCPRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5THU7</accession>
    <name>A0A8J5THU7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Progesterone-induced-blocking factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PIBF1-L</name>
        <name evidence="3" type="ORF">Hamer_G022051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005701">
        <property type="protein sequence ID" value="KAG7175514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5THU7"/>
    <dbReference type="OrthoDB" id="299638at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026205">
        <property type="entry name" value="PIBF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18950:SF0">
        <property type="entry name" value="PROGESTERONE IMMUNOMODULATORY BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18950">
        <property type="entry name" value="PROGESTERONE-INDUCED BLOCKING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="662"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="714" mass="81456" checksum="9707C50BC2FCB104" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIZ0</accession>
    <name>A0A8J5TIZ0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="1">DMQ hydroxylase</shortName>
            <ecNumber evidence="1">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">COQ7-L</name>
        <name evidence="2" type="ORF">Hamer_G009802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="1">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIZ0"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000377">
        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="192" mass="21468" checksum="B465E7ED39BC482E" modified="2022-05-25" version="1">MYRPPLFHGLRLYSTKSAQNKELIDRIIRVDHAGELGADRIYAGQMAVLGKSSVGPVIQHMWDQEKEHKAKFEELIPKYRVRPTVLVPIWNVAGFVLGAGTALMGKEAAMACTVAVESVITDHYNSQLRELISLGEEENKELIETIKKFRDDEMDHHDTGLLHDAELAPAYTALSTVIKTGCKAAVWVSERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJ02</accession>
    <name>A0A8J5TJ02_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CaM kinase-like vesicle-associated protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CAMKV-L</name>
        <name evidence="1" type="ORF">Hamer_G008495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7172983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJ02"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="243" mass="26706" checksum="B13409B301DB977D" modified="2022-05-25" version="1">MTMACELQHKYSPDAQRRMGHLAGEMRLNYPTRREITLRLQHWGVFLTTQGGVFHTTQRGVLPTTQGGVFPTTQGGVFPATHGGVIPTTQGGVFSTTQGGVFPTTHGGIFPTTHEGVFPTTHEGVFPTTQGGVFPTTQGGVFPTTQGGVFPTTQGGVFPTTQGGATKGLMIMENKKDQKKKYKAIRVKNTKQKNKTKDKFGEEEINEDRKIKIKQNIEIDTQIYGRQRYFSPPVGNKYSMGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TK70</accession>
    <name>A0A8J5TK70_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative methyltransferase-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Mt-L4</name>
        <name evidence="1" type="ORF">Hamer_G015505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TK70"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF10">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="184" mass="20812" checksum="A2A829D8FA87C2F1" modified="2022-05-25" version="1">MLPVASSRHKPPFYFNNNLTAFHQYAETPQVRCPEKQYFGGMKSKAGPVDGDKAVCLAPVYNITPGDCIVYAFDPTMGVEDHRRSDKIYFYNLGVGPADLHTKLGGVNATVRTLGHIIDMLGHINKYLGFTTFDARRTPHDDLWYTTDRLPDLVFASCYELAWAQVDFPNCFEAYETPVEYKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TK82</accession>
    <name>A0A8J5TK82_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G031752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008819">
        <property type="protein sequence ID" value="KAG7173823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TK82"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7173823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40709" checksum="478CF9802557E7A4" modified="2022-05-25" version="1">MLGTREHLRTKEDLNERTPENERTRERENTGEQTHLRTETPENAIDEEEFSKEFLGQLSSDIRLLHQCSHQARTASARTVVLNYRPSFLGNLLGLSGNAPGQTAVAVSLLRWPFILLAVYLIYIFLYPNRRAIIISSREHVQHDESWSYMMHCRRDNLARFMEDMTDPGLPPPTQAAGDRLQPGPASRAARSDPGPEQERISQEDQQNFLSVVLGPSTNTPGLSSLWIRTSSEDLLSDDLPYHPLPPNSTVPVAVSSYRYLQQDPDLTTLHPFVGQLVRSFDGHLNHRFRNSNYAAYFRPSVQFGSHLPLEQRGLGGWFSTLENWLDQLSETTKGEQEAQIGFRDYWTGDHPGLGGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TNY0</accession>
    <name>A0A8J5TNY0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein 45-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Lrrc45-L</name>
        <name evidence="6" type="ORF">Hamer_G009031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TNY0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052116">
        <property type="entry name" value="Centro_Cilium_Assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23170:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23170">
        <property type="entry name" value="NY-REN-58 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="474"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7176253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="631" mass="71245" checksum="867EEB76C6B6FE50" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J244</accession>
    <name>A0A8J5J244_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G019554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046868">
        <property type="protein sequence ID" value="KAG7153492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J244"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="147" mass="16798" checksum="D8D2A4D9B2DB8B1C" modified="2022-05-25" version="1" fragment="single">RWSYCSMWPTEMELLVCDLQRDGATVGMWSTDMWHAGEMELYVAWAESGATVACGSKRWSYCSMWSTDGATVVCGSQRWSYCSMWFTEMQSTVLWCYCSVWSRAGASVVCGLKLVLLKYVVYRNLCYCSMWSRLNATVVCSLELVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J6L5</accession>
    <name>A0A8J5J6L5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">NDUFB8-L</name>
        <name evidence="1" type="ORF">Hamer_G019507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046868">
        <property type="protein sequence ID" value="KAG7153451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J6L5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="146" mass="16223" checksum="C1F72AC570E2BF33" modified="2022-05-25" version="1" fragment="single">SPANMAALTRCLLKTKPLGSLTGVQLTRAAGKERAAAARKYGLRPEEYKPYPDDGLGYGDYPDVPLVSAESRDPYGNWDYPEHRRNFGEPIHADFEMYGLDRVNASQKLRFSPRQQALTFFAVMAGCPNNTLKKVSSTTHLSQLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J9F9</accession>
    <name>A0A8J5J9F9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043527">
        <property type="protein sequence ID" value="KAG7154902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J9F9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="111" mass="12901" checksum="6B516627104A350C" modified="2022-05-25" version="1">MTHLFEELFTGESQFSKHFLSRLREYNSLFAMTSFGHKDASVQGKRENNSHIDCGCPREKKILVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGD4</accession>
    <name>A0A8J5JGD4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G010047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGD4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="146" mass="17094" checksum="C6030AE070F3ED5A" modified="2022-05-25" version="1">MDTPDTKAGMKDLMLRNQFENSCPPELTSQFKIHKAGTLIQMAEKANAHFSAYGYQTRKEWQGKKPLPPPQYIDQSQQGNQHLSRQHPSYQTYKKDQTKWRSGFHHSDIRQQKTAATAFHHNEDPEPRQKLQSPPQDDSEQRHHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGN5</accession>
    <name>A0A8J5JGN5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G024631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042058">
        <property type="protein sequence ID" value="KAG7155305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGN5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="113" mass="12321" checksum="24CFD40DF537447F" modified="2022-05-25" version="1">MRPILMPSPTTGYVSCKCNRMVSTDDRYRNIENCAISRVFRPVCGSDGCKYINGDALICAQNQDRAQGKSEDLVVKEADDELCEDNDTTTGNTIITEADNGTTVLTTTADTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGW1</accession>
    <name>A0A8J5JGW1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Delta-like protein D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dld-L</name>
        <name evidence="15" type="ORF">Hamer_G014827</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035946">
        <property type="protein sequence ID" value="KAG7157962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000520">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053066">
        <property type="entry name" value="ADGR_G7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01983">
        <property type="entry name" value="NOTCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1180"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1215"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1247"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="222"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="260"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="349"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="14">
        <location>
            <begin position="1035"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="487"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="713"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="502"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="743"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="762"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="781"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7157962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1300" mass="141147" checksum="4109CD03FA7D05F5" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHW4</accession>
    <name>A0A8J5JHW4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036528">
        <property type="protein sequence ID" value="KAG7157875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHW4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="155" mass="17850" checksum="48242B961548E214" modified="2022-05-25" version="1">MDKITKIVPDRQFGAIEYNQDSSCPEYSQTPVTRPLQSESVISKSVVQWQQLQQLAILLNTNDRREVPTVPVSYAAIEKSSSPYEYQRPYTNPSTLTPPTAAIQYNQINVTSSPYMYHHPERHPSSLSPPKHQINYAPQLYQHIYYPSDLYMKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIP8</accession>
    <name>A0A8J5JIP8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">S-antigen protein-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Sant-L5</name>
        <name evidence="13" type="ORF">Hamer_G011430</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGR C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIP8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021839">
        <property type="entry name" value="EGR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11914">
        <property type="entry name" value="DUF3432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="Filamin" evidence="11">
        <location>
            <begin position="773"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="161"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="243"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="705"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="705"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7158757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="826" mass="92192" checksum="3F0D85520769A9EE" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ35</accession>
    <name>A0A8J5JJ35_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase ppk1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ppk1-L2</name>
        <name evidence="3" type="ORF">Hamer_G031763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042459">
        <property type="protein sequence ID" value="KAG7155233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJ35"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="59"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7155233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="239" mass="25913" checksum="E22732207F63C02A" modified="2022-05-25" version="1">MTSLVQVTPVSHNSSSSTTSTNSHYSSSSTTSTSSHNSSSSTNSSSGGRDLPQLTWDRLHLVGNVGTGEFGVSHHGQLTLSNGDVTDVVVKILHSGKANTKEARILHELAGAGGAPILYGVTTKPHAIVMQYCRGVLLSSILNSFMYDVYHRQEAYDATCVAVAEFHGAGYSHVDLHAGNIIIDTSTSPYTCHLIDVGLSERIPPDDDWWEKIDWRDLQDIQTRLHLNSPDDIGLRELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JM19</accession>
    <name>A0A8J5JM19_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4789 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G023636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038326">
        <property type="protein sequence ID" value="KAG7156883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JM19"/>
    <dbReference type="OrthoDB" id="6328618at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031993">
        <property type="entry name" value="DUF4789"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21177:SF7">
        <property type="entry name" value="GH11627P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21177">
        <property type="entry name" value="IP06524P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16033">
        <property type="entry name" value="DUF4789"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035261342" description="DUF4789 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4789" evidence="2">
        <location>
            <begin position="38"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4789" evidence="2">
        <location>
            <begin position="115"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4789" evidence="2">
        <location>
            <begin position="205"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4789" evidence="2">
        <location>
            <begin position="289"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4789" evidence="2">
        <location>
            <begin position="373"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="428" mass="47962" checksum="DBD5FC74F4896769" modified="2022-05-25" version="1">MLSVVVLVLATTSVWAGPARERQLKPCPEGFEAVVVDGKQDCVCADYHVYWPNTGLCYPEFTRGPCGQGQQLAANDTGHAECRCPGFWARWTDGACYQEYTQGPCNVGELFMGRGPSTDGFCSCTAELIMHYFRADGRCYPLYEQGPCPKGHLLKFDYRTLEPVCECRDGYMLEEDGSCYPLNTAGPCDQTACEDGINCYLRNLDTLKTECKCLPGNVTTADGHCYEPYSRGPCQLGDWLVFSQPGVAVCERKTHCTRFDNWFFWTPDQRCYRQYSRGPCPAGQLFYLDPNTGISGCHCRKEWTPYYWEADGSCYEQHSVGPCPVGMYFSFNQTSSQTECNCFTSHVLHEESKTCYERMTTGPCSEGQLVVEDPNTGRMACDCHAGMTTHYWQADGQCYQHFLQGPCSKGQTFRLDRATGVPACITWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMH6</accession>
    <name>A0A8J5JMH6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative pol-like 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pol-L30</name>
        <name evidence="1" type="ORF">Hamer_G010025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMH6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="223" mass="24858" checksum="0DF78F322DECACEE" modified="2022-05-25" version="1" fragment="single">INTFRRHLRQYPSPEGVKLLRAAVQHARQITQKIREDRWLEWCATFNAHTSLSEIWSKLRIATGKLPRAPAHPQPLQEANRLAEHFAERSSPAQLYPEIRLHLQQVQLEREKTWLLCPADAVNRLKLKDTILSKGPDTMSPDYSTPALWESSPAVFNILQTGTRKADCNMKALTPHNGSVEPTSTKAGAAFTIEGDGCSTLQVELAAILGALRHASINSEQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNB4</accession>
    <name>A0A8J5JNB4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G011363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNB4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="44" mass="5080" checksum="DB82E79821CA40B1" modified="2022-05-25" version="1" fragment="single">MLPVYGKQQMQRKANKDALEKLSKVHPLPSLILHWPKINSSLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNS8</accession>
    <name>A0A8J5JNS8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative calphotin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G016225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNS8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="129" mass="14139" checksum="E88783C0F2AC6B07" modified="2022-05-25" version="1">MLHHTTTCCTTSPPAAPHHHLLHHITTCCTTSPPAAPHHHLLHHITTCCTTSPPAAPHHYLLRHITTCCTTLPPAAPHHHLMHHITTCCTTLPPAAPHHHLLHHITTCCTTSPPAGYEVLATFVYKQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JP37</accession>
    <name>A0A8J5JP37_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane channel-like protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Tmc5-L</name>
        <name evidence="9" type="ORF">Hamer_G006626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JP37"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012496">
        <property type="entry name" value="TMC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF43">
        <property type="entry name" value="TMC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07810">
        <property type="entry name" value="TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="628"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="683"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="785"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="TMC" evidence="8">
        <location>
            <begin position="619"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="853"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="889"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="901"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7156639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="916" mass="105366" checksum="607567DFC18E35BC" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JP75</accession>
    <name>A0A8J5JP75_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat, PH and SEC7 domain containing protein secG-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">secG-L1</name>
        <name evidence="4" type="ORF">Hamer_G014076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JP75"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7161431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="680" mass="76575" checksum="BFF3006A1EC1D144" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPD9</accession>
    <name>A0A8J5JPD9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Synaptopodin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Synpo2-L</name>
        <name evidence="6" type="ORF">Hamer_G008941</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the synaptopodin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPD9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032233">
        <property type="term" value="P:positive regulation of actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051976">
        <property type="entry name" value="Synaptopodin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24217:SF0">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24217">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="167"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7158293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="214" mass="23416" checksum="22449B1F154775BC" modified="2022-05-25" version="1" fragment="single">MSMPVRAGWVPCVGFQPPKPMVMMIEEADVIAEECERAFQSVRTKNVSAGAPLAPPPPARPGSGTEGVEDEVTPRAPTSRRPVSMPPLHDTEGKKPAMKLLMNPKGVQDFHAVQEHYQTLMNAAPPSPEVGKIVTEVQSPTGKGAELFAKRKKRMDKFIVDETTVQKAQQQTTTMTQQSFSSSSNFSSSSTGTSSYSTKKQAELERDRQQEQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPW1</accession>
    <name>A0A8J5JPW1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pleckstriny domain-containing family A member 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PLEKHA3-L</name>
        <name evidence="8" type="ORF">Hamer_G011279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPW1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01247">
        <property type="entry name" value="PH_FAPP1_FAPP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000085">
        <property type="entry name" value="Pleckstrin homology domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF27">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7158623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="214" mass="24086" checksum="6526140F0CC12A07" modified="2022-05-25" version="1">MEGILYKWTNYWNGWQPRWFILDQGVLAYYKSQEEVNQGSKGSVKLSACEILVHPTDTMRIDIVIPYEQHFYLKAPSPHERHAWLVALGSAKAGIPPAIPQTKIEKDIVKAKKSELRLTCDLLMKQVYSVKTAANNPDGPDLEKLDESTTLLSATCDTFIHTLEECMKLSNTSPTPQLSGDSPIPPIILLKERKSSSTSTPITTRQNSTERRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQC8</accession>
    <name>A0A8J5JQC8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQC8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="83" mass="9681" checksum="AA451AC54AB3F490" modified="2022-05-25" version="1">MRYGTMNEAWLLFITIQLGRQRLAEVRFGLRAVYRNLTGYLGCNWTTTTLVEATGRLEGRTGLHYRGNWAMADYGLDWAIRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQI9</accession>
    <name>A0A8J5JQI9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G030330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027873">
        <property type="protein sequence ID" value="KAG7162271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQI9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="38"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7162271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="414" mass="44395" checksum="E9FBA8B7270F5420" modified="2022-05-25" version="1" fragment="single">ASKVKLFNAVSSQLLGDSVDISLREDHGEASQVNVVESRSVTDELRLLESQIKLKEAEAIARRVGIRQAEAEAKAKEAEAKAKEVGIRMVGLTKMRSWTRSPPNGASKFSTYPCSHCGKPGHRAEFCWTRLQLNTGKPAMIVTEETYTPSVGMMAGLSKADSMPIALVSTRGEAQESTVSVLPSRDFDPFQESFVKDPDVGTFRPFLSQGTVEVDGVETPVTILRDSGCLQTLVKEGVIAARKTGKYVVLGSLWGQGVAPLVLVRVKSSCFSGIANVACVHELPVAGVDLILGNDLAGGQMGNVTPPPVLRENPESTAELQQFEDDMLGVFPLCAVTRSMSMTNDHKVIPDVDDSLSLEGLFANPIASEDLSSSVNAVTGRVALIAAQEQDDSLRLLFDQVSKSANDSGPTTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JR65</accession>
    <name>A0A8J5JR65_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G019413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027477">
        <property type="protein sequence ID" value="KAG7162690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JR65"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37492">
        <property type="entry name" value="SI:CH211-171H4.7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37492:SF4">
        <property type="entry name" value="TSC22 DOMAIN FAMILY PROTEIN 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="151" mass="15979" checksum="F4C620C9E0E45E01" modified="2022-05-25" version="1">MPLTAALCSSQQHYAPHSCIMPLTAALCSSQQRYAPHSSAMLLTAALCSSQQRYAPHSCTMLLTAALCSSQQRYAPHSCTVLLTAALCSSQLHYAPHSSAMLLTAALCSSQLHYAPHSSAMLITAALCSPQQHYAPHSSTTLLTAALMLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JS37</accession>
    <name>A0A8J5JS37_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin-Y-like protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ccnyl1-L</name>
        <name evidence="3" type="ORF">Hamer_G017452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7160004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JS37"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.30">
        <property type="entry name" value="Designed four-helix bundle protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7160004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1182" mass="133441" checksum="5367CEA32383E4B0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSJ1</accession>
    <name>A0A8J5JSJ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G016326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSJ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="211" mass="24211" checksum="FF50FEB74D99C416" modified="2022-05-25" version="1" fragment="single">VQPNTCTHKHNIHVDVSSKGWQVFGIPVKEENSDNDGFNEELKGKIKEIDEIVKEEEVYCDEEFSCEKPDQGLKVKENDLENYVFVKVGILDSDESKKEDTTDGDLYILQNPRDIDDLLYQEDDLHMDLHDVLHKPAPPESNVNSGYRLIQLCLNKPLKTQLEFCSMQPTLHPDSFFLSLLLSFTETSECLLHMLINSCICQTLLVIKINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSV1</accession>
    <name>A0A8J5JSV1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="8 9">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Eif3b-L</name>
        <name evidence="12" type="ORF">Hamer_G002819</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSV1"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001060">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000235">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="57"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7163606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="694" mass="80810" checksum="D9FECF6838AB6BD5" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTK7</accession>
    <name>A0A8J5JTK7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PHD finger protein 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Phf10-L</name>
        <name evidence="12" type="ORF">Hamer_G007497</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7161838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1903104at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PHD2_PHF10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WH_NTD_PHF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF4">
        <property type="entry name" value="PHD FINGER PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="1294"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="1350"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="175"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="235"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="415"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="770"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1260"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
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            <begin position="456"/>
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            <end position="851"/>
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            <end position="876"/>
        </location>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="1003"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7161838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1519" mass="166451" checksum="3991D5296128FBF2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Homarus americanus</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="match status" value="1"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="106" mass="11376" checksum="19B42B3394AEE964" modified="2022-05-25" version="1">MVLLRGGGGSANKGATRGRRRPLVTWLTLRSVWRTRKMARKSPQCALLAYYRQGVALQCLGRHADALAAFSSGLAQDPKSLQLLAGLVEAAMKSPLKGESLVLCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUU9</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            <dbReference type="PubMed" id="34162536"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7164475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="52" mass="6121" checksum="EEC697C1587D7DE7" modified="2022-05-25" version="1">MIEILSIFRVRCAVYFKKICTVYTVFALPVFRPVLTNFGMMAKLQKFQVVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVG0</accession>
    <name>A0A8J5JVG0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Kohn A.B."/>
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                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
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                <person name="Greenwood S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="104" mass="11798" checksum="E5CF3549C19A011B" modified="2022-05-25" version="1" fragment="single">ATLAYGEKEIVNLLEVYQIEPQAKQKVRHVGNWLPRTPGHHAPSMTSPKEDVVTRRTDLSGLHLSCLTLSYSPFMLTEEQGDGSARLSGWMADIWEVMRERSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVJ5</accession>
    <name>A0A8J5JVJ5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhophilin-2-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rhpn2-b-L</name>
        <name evidence="4" type="ORF">Hamer_G019433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024443">
        <property type="protein sequence ID" value="KAG7165242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVJ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051497">
        <property type="term" value="P:negative regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09244">
        <property type="entry name" value="BRO1_Rhophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047138">
        <property type="entry name" value="RHPN1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23031:SF15">
        <property type="entry name" value="LD12055P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23031">
        <property type="entry name" value="RHOPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="52"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="460"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7165242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="542" mass="60960" checksum="525522F5B5252F8A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXX5</accession>
    <name>A0A8J5JXX5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fem-1 B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FEM1B-L</name>
        <name evidence="7" type="ORF">Hamer_G002757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fem-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXX5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000264">
        <property type="entry name" value="Fem-1 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7163559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="749" mass="82496" checksum="DAAFBE4CAAA1F156" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXY1</accession>
    <name>A0A8J5JXY1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029486">
        <property type="protein sequence ID" value="KAG7161439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXY1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="146" mass="15578" checksum="F8371520A91D662F" modified="2022-05-25" version="1">MVAIQRWGRSRCWKGAKCCNQSPCAACAKRFEDGVVVGSAVTRLDYYMYGAVQWTVLRRSSSSRGGGGSSSGGSCRIGVVSGSDGGRASGYSATEMGAKGGASGVGYVPRGKSKEGDDQVLCIYLGGYEEDVLRRKEEARRRRSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYL1</accession>
    <name>A0A8J5JYL1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KASH5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Ccdc155-L</name>
        <name evidence="4" type="ORF">Hamer_G011116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYL1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000800">
        <property type="term" value="C:lateral element"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090619">
        <property type="term" value="C:meiotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090220">
        <property type="term" value="P:chromosome localization to nuclear envelope involved in homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051653">
        <property type="term" value="P:spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034397">
        <property type="term" value="P:telomere localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028170">
        <property type="entry name" value="KASH5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028168">
        <property type="entry name" value="KASH5_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47300">
        <property type="entry name" value="PROTEIN KASH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47300:SF1">
        <property type="entry name" value="PROTEIN KASH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14662">
        <property type="entry name" value="KASH_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KASH5-like coiled-coil" evidence="3">
        <location>
            <begin position="57"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7166287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="769" mass="85764" checksum="5EC477669C6AA309" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZN8</accession>
    <name>A0A8J5JZN8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tigger transposable element-derived protein 1-like 165</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TIGD1-L165</name>
        <name evidence="2" type="ORF">Hamer_G003567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZN8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="276" mass="32274" checksum="80BF03C548F8AD20" modified="2022-05-25" version="1">MREVLLCPKQAGDAWKEVTVRCLCAAWRPLWPECVLQRDFEGFEELEEEAVVHEIVSLGNSMGLEVYDDDVEELVEEHSKELSTEELLELHKEQNETLKRSLTSEESGEDEDKEESRIIPAKDLKDAFFCWSKLSKLAEDYHPDVGSVQKAIIPRLHFQINRHHDHGHSTDCHPCNCQLQYCEPLARFLMDSVKKRLDPYIEMRDVRAAAFLDPKFKLDWLSSQEQKDQVLIDIKEMLEESEKVQEGSTEEDPYFSPSYHHLQLSHKINEHQREVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZS5</accession>
    <name>A0A8J5JZS5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NOP56-L</name>
        <name evidence="8" type="ORF">Hamer_G012957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZS5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="637"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="776"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="821"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7167492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="912" mass="101586" checksum="6CDE66ACA99D588B" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K093</accession>
    <name>A0A8J5K093_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TAZ-L</name>
        <name evidence="16" type="ORF">Hamer_G005005</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:43816"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:43817"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:43818"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the taffazin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K093"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="15">
        <location>
            <begin position="82"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7164620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="283" mass="32465" checksum="71075040098FBA9C" modified="2022-05-25" version="1">MAPPEEAPGTGMPLTVNLKLKYGWPFPDMKDPPLSFKVKSSIIIPLVGTFSKILLKWCNSINGHNIEQLQELVGNRPAGVPLVTVSNHYSCIDDPTLWGLLRWRELWSAQAMRWSPAAHDIAFTRRLYNWFFSSGKCVPIIRGLGVYQEAMDFLIERLQAGQWVHIFPEGKVNMSMEHMRLKWGVGRLVYESSICPIVLPFYHIGMDTILPNRSPYIPRVGKTVTVVVGEPMDFKQLVSEMKEKQEDPATARKIITDRIQDELKRLRGKAEELHEKMLQQRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0W9</accession>
    <name>A0A8J5K0W9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025340">
        <property type="protein sequence ID" value="KAG7164533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0W9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="251" mass="28838" checksum="EBBC7A16692F977E" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTYKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVGLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K160</accession>
    <name>A0A8J5K160_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020459">
        <property type="protein sequence ID" value="KAG7168225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K160"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="74" mass="8010" checksum="58A5A43387CDE737" modified="2022-05-25" version="1">MVGAMATIIMGYSVQHIIAAVVNFIIVAVQLHITASIIMKNTKNVKEDKELLVKAGPEETRVVEASTSLPKEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1B7</accession>
    <name>A0A8J5K1B7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRD4-interacting chromatin-remodeling complex-associated protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BICRA-L</name>
        <name evidence="3" type="ORF">Hamer_G004325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015671">
        <property type="entry name" value="GSCR1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43670">
        <property type="entry name" value="HEAT SHOCK PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43670:SF131">
        <property type="entry name" value="LRRGT00202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15249">
        <property type="entry name" value="GLTSCR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLTSCR protein conserved" evidence="2">
        <location>
            <begin position="1773"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        <location>
            <begin position="2448"/>
            <end position="2465"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7163224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2465" mass="263449" checksum="2AC782CEBE14AE6F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3N5</accession>
    <name>A0A8J5K3N5_HOMAM</name>
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        <recommendedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase chain 3</fullName>
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        <alternativeName>
            <fullName evidence="8">NADH dehydrogenase subunit 3</fullName>
        </alternativeName>
    </protein>
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        <name evidence="11" type="primary">ND3-L3</name>
        <name evidence="11" type="ORF">Hamer_G005554</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
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    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7166450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
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        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0813">Transport</keyword>
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            <end position="51"/>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7166450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="78" mass="9019" checksum="1E3176F3D7461925" modified="2022-05-25" version="1">MRRSRKNSPFECGFDPKGSARLPFSLRFFLIAVIFLIFDVEITLLLPLASIIHLTNIFSWALTGILFLLILLIVLYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4I3</accession>
    <name>A0A8J5K4I3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G005187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
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            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4I3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="186" mass="19611" checksum="30D0D20C7D844D31" modified="2022-05-25" version="1">MAQCTSTGGPAGTSPTSTVASPGQHHRSGDEHSPHVVVIAGPIPSPQSNGNLQGVGAGLLYPALPQQAQAAGHPPAPPAAQGKASMGMSPIKFRAWAFSIATYSNRCNWPQALAAGYVLLLCETEVQCIDARVNKCVYDNLMVEEAIRAVESVVVSPKCFVGAWADFFAYTQEPGDNVSRYVVRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5H9</accession>
    <name>A0A8J5K5H9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Midasin-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MDN1-L7</name>
        <name evidence="2" type="ORF">Hamer_G018434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7168003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5H9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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</entry>
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</entry>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            </authorList>
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            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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            <strain evidence="2">GMGI-L3</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="250" mass="27665" checksum="E0EE88D64CE21E1C" modified="2022-05-25" version="1" fragment="single">MESTRSKTEVWLIGQHITEITVAQLPSRGDVLRLFFHGHNEHKKTVNDSASEVAASVISFWNKARIPTITEKSIGQKVVDLFLMWKGLKKNCTRTTDTQRKKEETFCDELEDLFDVAHPKAMQLLTIKEDRAFLAAQREKGRRGVIAGVDKKIACSIKRREESKSKQSLQQNQASSALEYDELGSSSETESQSSSSSSTSSLAISPVLSSSNRKRATLKVITPELSSTLDRTGISHRSALRIVSATAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MIF2</accession>
    <name>A0A8J5MIF2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetylcholinesterase-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Ache-L2</name>
        <name evidence="6" type="ORF">Hamer_G010709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MIF2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="17"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7153396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="218" mass="24649" checksum="19C4408CDD309BD1" modified="2022-05-25" version="1">MRRRHYTISSLWFNVQHAEHVAHMAETLYYSSRARYSLDTLLEEMSQALTDYMFLPPSQEAAASLAAANYTVYNFIMTHRDSSGVVWGGPHLFEKASDLGMKTPLLKTGVSHGDEQLFLFSSQEYNYETETFSSSFVSLFVNFISRGRPQGVEGERSEWTPVVAGEPVGYYNISLQPSMVHTPYNAKGRNFWLQTIPLLETFLETGAASHPADVKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJQ9</accession>
    <name>A0A8J5MJQ9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G022335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045864">
        <property type="protein sequence ID" value="KAG7153979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJQ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="152" mass="16506" checksum="F4E3CCC301112B28" modified="2022-05-25" version="1">MGVLVYPLTSLLRRVNRTGTSGVERCWLETGVREIGVLETEILETGVLETELLETGVLETGVLETELLETGVLETGVLVETWILWVSGATHPQQVPLPSLLLDFSGVEFSGSTNGCQESIVIKFGCLWYRTPEVNFEQILAIGAAGSSRTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK05</accession>
    <name>A0A8J5MK05_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045830">
        <property type="protein sequence ID" value="KAG7154040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MK05"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="84" mass="9796" checksum="3FE40485E0D7AEB8" modified="2022-05-25" version="1">MKSQIDSPRAPPGILQQLHDPIERHTRCHCRPLFHHSCCTHHLPWLTLSTAPKNVTQRQRAKNPRKATDDAWHTHTFTHQPLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK24</accession>
    <name>A0A8J5MK24_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Artichoke-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atk-L4</name>
        <name evidence="10" type="ORF">Hamer_G020399</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045270">
        <property type="protein sequence ID" value="KAG7154102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035146429" evidence="8">
        <location>
            <begin position="27"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1225"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="601"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="1126"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1197"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7154102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1291" mass="144755" checksum="66BE80F39DF82BDC" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKJ8</accession>
    <name>A0A8J5MKJ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger HIT domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ZNHIT1-L</name>
        <name evidence="7" type="ORF">Hamer_G014974</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKJ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="6">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7154625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="206" mass="23779" checksum="AA890712B4BCB2F9" modified="2022-05-25" version="1">MVNVMKGILIKCDPVMKQFLLHLDETLKLGSKFVLVDLDDCHLFVQPEVYNSLKMSSRLKDASTRRILDEGARRRRARKALEALEQDNFHDDPHANLVMSKKAPKFEESLDGSRNKDRKRKTRSTEHFKQRFRKNFPILLEEEQALYPEGPNYLTIQAPPSQLPERHICAVCGFPAPYTCIPCGARYCSTKCLSTHEDTRCLKWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLA1</accession>
    <name>A0A8J5MLA1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041777">
        <property type="protein sequence ID" value="KAG7155392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLA1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035264422" evidence="1">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="9486" checksum="5B181F3479083876" modified="2022-05-25" version="1">MSPVLPIMPQCISLLFLLIHLQHLPPTSNTFLYLPSTYPPPSITSLQIPTLYLQHFFLTSALHLQHQHPPSISIANLPPSTHTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLV8</accession>
    <name>A0A8J5MLV8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">LIM/homeobox protein Lhx9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lhx9-L</name>
        <name evidence="13" type="ORF">Hamer_G024144</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039540">
        <property type="protein sequence ID" value="KAG7156186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLV8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000027">
        <property type="entry name" value="LIM/homeobox protein Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF168">
        <property type="entry name" value="PROTEIN APTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035217880" evidence="11">
        <location>
            <begin position="20"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="39"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7156186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="204" mass="23059" checksum="5664001AA4748C07" modified="2022-05-25" version="1">MGRCVMLSCFVSWSELVPGGEMSMDGYRYDHQGPGQNRTKRMRTSFKHHQLRTMKSYFNLNQNPDAKDLKQLAQKTGLSKRVLQVWFQNARAKWRRNILKQEHERHVGDKLKDQSGLLGDLRPVDSLGPGLTDIYAMSSGDEGSQSLQFTDMCQGDKRCTQDTQRADPVALTGVYTLLLNTPNSPGSDEDFSARNVINVFNNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MN31</accession>
    <name>A0A8J5MN31_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">gck-1-L</name>
        <name evidence="20" type="ORF">Hamer_G021396</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010037266">
        <property type="protein sequence ID" value="KAG7157598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MN31"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000092">
        <property type="entry name" value="Serine/threonine-protein kinase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046409">
        <property type="entry name" value="PDC10_dimerisation_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048288">
        <property type="entry name" value="PDCD10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20929">
        <property type="entry name" value="PDCD10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="12"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="283"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="391"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG7157598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="582" mass="65608" checksum="D8DFDE9931FA8A90" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNI8</accession>
    <name>A0A8J5MNI8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G018716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036987">
        <property type="protein sequence ID" value="KAG7157657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNI8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="64" mass="6885" checksum="5884B5901A82CAF7" modified="2022-05-25" version="1" fragment="single">APPVPPWSAQAKDSLLYNAELLVWFNFGAAREDGTEYMQVSAPKDHWLTSGEGAAAGVTQLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPZ2</accession>
    <name>A0A8J5MPZ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPZ2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031720">
        <property type="entry name" value="DUF4728"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF11">
        <property type="entry name" value="LP21121P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15860">
        <property type="entry name" value="DUF4728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="147" mass="16538" checksum="21222FF953A38F53" modified="2022-05-25" version="1">MNYVAACIGIAQLVIAIYCLFNIDDAKKRLKFENAVTFGIVDPESDAAAYIFFAILIIVATIYIIAALVLIHGVRTKRRFLLLPWVFFTFLNMVMMFAAGILSLINSHGYALPIIVGCIVLAISMTWIYFTCVVFSFFQALQDGDYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQ68</accession>
    <name>A0A8J5MQ68_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G032198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032781">
        <property type="protein sequence ID" value="KAG7159696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQ68"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="280" mass="32123" checksum="F0D59F72A699C732" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTYKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQIGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDTEAVEVILKIRGTLIDNDQLGDCSFHSRKVPPINVNATKLSELVDLSLEVLEPPLTTSLTSQEMRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQG4</accession>
    <name>A0A8J5MQG4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7159949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQG4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="108" mass="12168" checksum="6C8CBFE28E6A2706" modified="2022-05-25" version="1">MDVILEGLTHMDVILDDLTHMDVILEGLTHMDVILEGLTHMDVILDDLTHMDVILDGLTHMNVILEDLTYTAIHKIYFTRTEYTPGQCSRSTSHHKLSTVTSLSVTCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRH8</accession>
    <name>A0A8J5MRH8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029518">
        <property type="protein sequence ID" value="KAG7161303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRH8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="314" mass="35836" checksum="E6B1A128CFB5742A" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERREAAPLSLAKTKHFNTAPKMGLEEETAKVKQRRALVKMTFTRKLNAFHTRVSQADPIAVQLQSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRP1</accession>
    <name>A0A8J5MRP1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G028705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029985">
        <property type="protein sequence ID" value="KAG7161104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRP1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="104" mass="11730" checksum="37C2F38770A4EF8B" modified="2022-05-25" version="1" fragment="single">AGATVVCGSQSWSYYSIVCSLQSWSCIYRAGATVVRGLQSWSYYSISFVTVVCGLQSWSYYSIVCSLQSWSYCSMWFTELSYYSIYVFTELVTVVCGSTELELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MS86</accession>
    <name>A0A8J5MS86_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">THAP domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Thap3-L</name>
        <name evidence="7" type="ORF">Hamer_G019948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028706">
        <property type="protein sequence ID" value="KAG7161933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MS86"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF2">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="101"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7161933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="201" mass="23304" checksum="82FFD8E9283749D1" modified="2022-05-25" version="1">MPATCVAYNCRIRQKKGTGISFHRFPFDRPELLKEWLKNIKRTNWQPSPTSLICSAHFTPDCFEGRDPRYRPKLTKLRFNAVPTIFDFSDHIQKSLFAARMPSCAAIGCKNRKEKKVDQNARYPEKPARSIHRFPVSDPPLLRKWLQAMKRDFIPNRQSFLCSDHFTEADLDNTDEIVRLREGAVPSVFDFPPYLANCSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTC0</accession>
    <name>A0A8J5MTC0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ionotropic receptor 93a-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Ir93a-L1</name>
        <name evidence="11" type="ORF">Hamer_G002714</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTC0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF39">
        <property type="entry name" value="IONOTROPIC RECEPTOR 56A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="244"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7163520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="541" mass="61266" checksum="B9AE9FFB114565E5" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTE0</accession>
    <name>A0A8J5MTE0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G002806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTE0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="57" mass="6205" checksum="CD54626504DC70A2" modified="2022-05-25" version="1">MASKTAIVLLAEGAEEMEAVITIDTLGGRSYCNSGRVDWCCSCMLQQRCCDPARCFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU77</accession>
    <name>A0A8J5MU77_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Solute carrier family 35 member F6-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Slc35F6-L2</name>
        <name evidence="2" type="ORF">Hamer_G002250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU77"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="357" mass="40100" checksum="9957E5A99C0226BC" modified="2022-05-25" version="1">MGWTGKQMVLALVMVFTGSINTLTAKWADRIQSVNRQGHKTTFSHPFFQADCMFIGEMLCLATFYLQLMITRRSQRDTVEMAPDPHQVVDVPRYIFYLPAICDVTATSMMCCHRVHGVTVGGVLRSSPQVLPLAGHRYRHRRPYHRDLLIVAAQVFTATQMVVEEKFLAKYKAPPLMVVGWEGVFGFLTLSVLLVPMYYIPAGKFSGNERGVLEDAIDAFVQLSNSGTLVASIILTIISIAFFNFAGVSVTKEFSATTRMVLDSVRTLVIWLVTLALRWQTFQYLQPIGYVVLVVGMMLYNDVLILPFLRRRGLVRDQPSESDSQPVIKSTDEIVRRDPYQLGSAVRLPNMAMCSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUM3</accession>
    <name>A0A8J5MUM3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUM3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035313610" evidence="1">
        <location>
            <begin position="23"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="290" mass="33005" checksum="4262CAEF319878E0" modified="2022-05-25" version="1" fragment="single">MNWFKLELLMIGAVHLIKILQSDLYPRNDCKTQGVSTLLHVLVKEEDHIHMPVVNPAESLLKLSLQAVCSNVKVMVTRAADFTESADAVLQVAEEQVHKLLLSQTQNRHLTVTPYDYRSYNFDDILPYLTNLHTLNMELTHEVSISNICDIAENCKLIESLTLTCPALRMQAVDINEDLIAIEEPERNSPSPLLIKNIPGKKMNEPQESLHILRSFPEYQALLKIDPAPYEKDNSQIPNFLRLHTLQFFGIRSVEAAALYKCIKEPIVQTLTFVAQEIGDDCRIELNDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUX2</accession>
    <name>A0A8J5MUX2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine-rich, acidic integral membrane protein-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CRAM-L1</name>
        <name evidence="6" type="ORF">Hamer_G020825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026066">
        <property type="protein sequence ID" value="KAG7163909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6375777at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058698">
        <property type="entry name" value="CUB_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236:SF5">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26080">
        <property type="entry name" value="CUB_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035255470" evidence="4">
        <location>
            <begin position="20"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="89"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="479"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="559"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="710"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="815"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1155"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="854"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="885"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="901"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1172"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1243"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1270"/>
            <end position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7163909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1293" mass="135539" checksum="10289C4E7BC23394" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVD2</accession>
    <name>A0A8J5MVD2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="2">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Mccc2-L2</name>
        <name evidence="8" type="ORF">Hamer_G005165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVD2"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000046">
        <property type="entry name" value="Geranyl-CoA carboxylase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF47">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7164752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="567" mass="61632" checksum="6A5563D2442D4EBE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVI4</accession>
    <name>A0A8J5MVI4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RE1-silencing transcription factor-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Rest-L5</name>
        <name evidence="11" type="ORF">Hamer_G011922</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hunchback C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7165995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVI4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001839">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000614">
        <property type="entry name" value="Zinc finger protein 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7165995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="223" mass="25227" checksum="A512D3B5DA135A7B" modified="2022-05-25" version="1" fragment="single">VGLDTADEWSGRRGTSGIRKGITTSIKMHQCPYCPYSSTTKTNCTNHMRTHTGEKPFSCTMCPFRASQKGSLQTHLRTHTGEKPYACTLCPYRSAQMIHLRNHMRARHGWLADVGLDRDDGRGSAGAGKGFTTTSKIHRCPYCTYVTPVTTHLRDHLRTHTGEKPFSCPFCPYQATTKSNLTKHTRIHTGLKPFTCPHCSYYCTKKFYLDKHILSHTWSKPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVZ9</accession>
    <name>A0A8J5MVZ9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G004870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVZ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="147" mass="16575" checksum="F635436F41BD368A" modified="2022-05-25" version="1">MIAIDADYHRACLSRAYRKADAVECDSSESYAAKVIKAQAFNELLDYIEDHCGSGTVLSMTKLTAPYDKHLVSLRCPHSHGHTTRLRQDIVSMFPDIKAIEKPCGCWELVFNEDLSQVVEEMKDTTSPGMRILAPVAKILQRYILEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWP1</accession>
    <name>A0A8J5MWP1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Venom metalloproteinase antarease-like TserMP_B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Hamer_G024899</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022602">
        <property type="protein sequence ID" value="KAG7166401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWP1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13582">
        <property type="entry name" value="Reprolysin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035194874" evidence="9">
        <location>
            <begin position="20"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="10">
        <location>
            <begin position="174"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7166401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="484" mass="52389" checksum="34CE262FDCA166D3" modified="2022-05-25" version="1">MKTLAALLAVSCWGALSHASVVRTRPLKSSPATVRLSSPRSPLEPLHLQVEAFGQRHNLRLQPALSPLSVDFKLQRTAINEQGQVIIEDVAMEGEDAPLYEDPETGSVVTLDDNKVEGIITPTLTLMAASDGTHQAVRQYSAMPLHETRDYLEVPSGVLYNQNSSTNTRAVTSVSPEVYIIVDSTLAKQLGSNTKVRKYLSVFWNAVNQRYAAISDPKIKLVLSGALIVRKSAHEPYINDNFLLDNYIDGANTLNSVSDWLFQKKDDLSAYDLAYLMTGKDMADVQAGTIKEGLSGIAWKGAACVVAEANKRSFNTGMGEDQGAYYVGVMTAAHEVAHNLGSPHDGEGEATSCSWDDGYIMSYVSGKLNKLLFSPCSQKLMKKYFMTSDADCLHKAAMVPTINLSSKLPGELIPMDKQCQKATGQTNAFASKQVSEDSLCVELVCQWKVKEGNSVFTYTKSTGDPAAEGSACRSGGVCTDGSCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY88</accession>
    <name>A0A8J5MY88_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Solute carrier family 66 member 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Slc66a3-L</name>
        <name evidence="6" type="ORF">Hamer_G012909</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY88"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF3">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 66 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7167449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="208" mass="22643" checksum="3E9BDA4A2E61F270" modified="2022-05-25" version="1">MSLIIDALITFCDVTTIGLCGFNKVPQIIKLAKEKSVKGLSLASILLELTSYSIMFSYNVYSAYALTTYFEYPLLIVQDVVMLTLFLALSGRLSPVEILPVAALPCFAYSIASGTLPNSLIKTLVGMCTPISASSKVVALLAIIRSKNSESVSIPTWCISSYTSITRLFTIYVESADPALLMNFGTSFVLNTLIIIVAIIYKPRKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZF7</accession>
    <name>A0A8J5MZF7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G013329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015640">
        <property type="protein sequence ID" value="KAG7169703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZF7"/>
    <dbReference type="OrthoDB" id="10022583at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35555">
        <property type="entry name" value="ENDONUCLEASE-REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35555:SF3">
        <property type="entry name" value="ENDONUCLEASE-REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7169703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="632" mass="71731" checksum="19E3907C937CDD34" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZT4</accession>
    <name>A0A8J5MZT4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 157</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Cfap157-L</name>
        <name evidence="9" type="ORF">Hamer_G025334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CFAP157 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014886">
        <property type="protein sequence ID" value="KAG7170180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZT4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038844">
        <property type="entry name" value="CFAP157"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31954">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31954:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="50"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7170180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="414" mass="46722" checksum="54598A6F12FC963E" modified="2022-05-25" version="1">MVTITTMAPKGKKAGKKKGGKKRDKKEDEEEGKGKEVITELDKHYYLNQIQALEVKVKRSTTKCEQLDEAEQHARAQYDKLHADKTDIINFLKDRLSTLAKEAENTRLDLNDKIIALTRKLESLEEFRQHKEELEAKLCNLEEELVKNNEKHQEKVSFLEKASLVEAAALRAELEARITRITEDLRRAAQTEVHSTTRRALHENEALTKQLDVFREKISAFRAENQQLRDSLSDSQVREGLLQDTVTSVTARGEQRARLLQTVTERAEQHSHIWVDYDRLVMQGQLDASTQASCDLREKAAEKDAALEVTTSHLKQQDAARKMLHNTDDDEADGDHLAGTLEQLVSLLSSAESSQTISYTPPTTQSAAVTPDSPPHHAQEEVTENLGQVKYRAGDLGLLPRPHRKAKTQSAVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1G1</accession>
    <name>A0A8J5N1G1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial transcription rescue factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Mtres1-L</name>
        <name evidence="4" type="ORF">Hamer_G018572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012106">
        <property type="protein sequence ID" value="KAG7171456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1G1"/>
    <dbReference type="OrthoDB" id="4150at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903108">
        <property type="term" value="P:regulation of mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057896">
        <property type="entry name" value="MTRES1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13633">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13633:SF3">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25818">
        <property type="entry name" value="MTRES1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Mitochondrial transcription rescue factor 1 C-terminal" evidence="3">
        <location>
            <begin position="149"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7171456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="263" mass="29739" checksum="EC6B39B1D5196AB3" modified="2022-05-25" version="1">MALCVVNNVCVLQYIRNNNIIIREYTKRSVNPRGLSQMCFPKNLITTKRNDCYGLYGSGYTREESSLNSPFSPSRNLSSLTNTYLRRSFSDELTPINVLTLKTPCMVLATRNKSKGKSGKRGTRGQEEFSDDDESEDDDMELESGKDFRDIKARVPSLRMDAILKAGLGMSRNKVEAAFYGSKIRVNGSKILKKSKQLHEGDEVDVVKGPSSVNPDFLNISRVVIVKVGKYEEDSDKVSVKLRKYSQLLVDKYEDYARDDEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1S4</accession>
    <name>A0A8J5N1S4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Pex13-L</name>
        <name evidence="16" type="ORF">Hamer_G023076</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011989">
        <property type="protein sequence ID" value="KAG7171671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1S4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11864">
        <property type="entry name" value="SH3_PEX13_eumet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="171"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="336"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7171671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="389" mass="42386" checksum="E86F2E6215C2CDD1" modified="2022-05-25" version="1">MGGATGPTADDTFIRLAEDSSRQAFQSIESIVHAFGSVSMMLESTYHAVYSSFRAVLGVADHFSRMKSHFAQIFSALAVVRTLRWLYRKLLYLIGLRSQDPSLEAAWRTVGAHSESAAAIITEADIKASKSSWPIVMFLAVVFGGPYLIWRLLSSLAPTIAKNRNWLQGRGEHYAAVAKYNFEAGNRNELTFRAGQALFLAPKDQQPNVRGWLLASNKNQCGLVPANYIKILGLQSGISRPAECQSEVQGGRPLISNASSRIVASRIPDIPTPKFAQHIPHIVDGLSPVSTEYGVKSFSQGNDQRLQNNYGGQLQMNSSPVTSQTPGQEMMLGEGISHKQKPSHFDTQTPCGDDQEPCGDGQEPCGDDKEASGDDNEASGGDEEHKSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2R7</accession>
    <name>A0A8J5N2R7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="7">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RABGGTA-L</name>
        <name evidence="9" type="ORF">Hamer_G001080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="7"/>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2R7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="2 7" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7172086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="500" mass="56857" checksum="07FDF281AFF5E221" modified="2022-05-25" version="1">MHGRLKIKTTAEQAAEKQKEREGKRKLYLGGVTKAFEKRSSGTHDEEGLKITAQLLAANPDAATLWNFRREILLALKGDDESWEKLLTGELAMVESCLMKNHKSYGAWHHRFWVMMNFPKPPWKAELSLCDKYLKLDERNCELYFFLVFHELQTVVEAVFTDPSDQSPWFFLRWLVNRQEKVPRMLQVGYVRYKGDSGLVICVFSQPVPQRAVPFIRLNGADSDETLIWYAPNDEDYSNVWVAELNLSSVEAHTISLIIDPSMTEMLNVGEGSTQAIEWVTTLEVGGEELSDTARSTLEEVKDNCVTLDELDPGNKWVLLTLVDVMWALDCHTHQKKIHSYLSQLQELDVLRNKYYADMKSKLAMETSLKQYRIVAEVGSKFELSGHSLTRITLSHLLASTASIDLSRNDLTSISPLSNLVACRKLILDDNQIQNLAPLAGLKALESLSLTHNKIQSLEQLKVLEGLSALTELNILPFQSVKCFLDVERLKLHLHKNLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2Y2</accession>
    <name>A0A8J5N2Y2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Endonuclease/exonuclease/phosphatase family domain-containing protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">EEPD1-L2</name>
        <name evidence="2" type="ORF">Hamer_G031810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011453">
        <property type="protein sequence ID" value="KAG7172378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2Y2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="213" mass="23874" checksum="BA7945B8D295E514" modified="2022-05-25" version="1" fragment="single">ECKNKDNPKCLNCEGDHRTLATRCPIRKAIVNQKKEKEREKTQEQQNKTYSAVTKLTRETTKILEKVATPPPVNQPIVLQLGNNLSVKIMTSIIHAHIMNIARPGTFAKAARDMFAANNLPDMEFPNDVPSSEIFNFIYKSESTEIQIPTTHEPSTHEPSTHEPSTQEQTTSDIQPEPASDEESMEDSSEDETTTITEQAARVKTPKKNQTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2Y5</accession>
    <name>A0A8J5N2Y5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A</fullName>
            <ecNumber evidence="2">3.1.4.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Pde9a-L1</name>
        <name evidence="13" type="ORF">Hamer_G009643</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3',5'-cyclic GMP + H2O = GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16957"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="EC" id="3.1.4.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.35" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2Y5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000006">
        <property type="entry name" value="Phosphodiesterase 9A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0140">cGMP</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7172285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="356" mass="41321" checksum="BFD110EECD1AD455" modified="2022-05-25" version="1" fragment="single">PAVTLPATFFSPGTVREHVITLQREPPPFTKYNLTKETVENLKLPSFDVWQWEPNEMLTLLEHMYRDLGLMEEFCINPPTLRNFLVSVQENYRNNPFHNFRHCFCVTQMMYGIIHLCRLQEKLSRKAIGVLITACVCHDLDHPGYNNWYQINARTELAVRYNDASPLENHHCAVGFRVLANPECNIFSSVPEQVYKEIRADIIILILATDMARHSDIVDDFKKKLEVFDYKNNDHLNVLKMILIKACDISNEVRPSKVAEPWVDCLLEEYFNQAETEKQEGLPVAPFMDRDKVTKASAQIGFIKFVLIPLFESISQLFPQAEEVLVVPLRHAREHYEQLKEAEEDMRRLAQSKSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2Z6</accession>
    <name>A0A8J5N2Z6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DDE superfamily endonuclease domain-containing protein 51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G009711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2Z6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="48"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="159" mass="17729" checksum="0DD040AD9796BC80" modified="2022-05-25" version="1">MTVSWALDSELNTLKQVHNVPANRNSEDVKAARVAFAQYMCEDGIHQPLVYVDETGYNLYTCRTYGRAPRGQPVNRIVAGQRGSNVTLIAAIYNLAGLFYYEIHVTSVTKEVLKNFVTSLESVLGPEASVILMDNAPCHAEIEQEFEDRVIKKLPPNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N315</accession>
    <name>A0A8J5N315_HOMAM</name>
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        <submittedName>
            <fullName evidence="4">Crustacyanin-A2 subunit-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Cra2-L4</name>
        <name evidence="4" type="ORF">Hamer_G009620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF15">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035246778" evidence="2">
        <location>
            <begin position="33"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="3">
        <location>
            <begin position="59"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="266"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7172265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="354" mass="39700" checksum="D5D3E98B333DFA78" modified="2022-05-25" version="1">MGGVTGGGGWGRRRMGVWAALLFLVQVHHAHAFGIPEFLVFGNCPDLQVDPNINFEKFSGIWFNMEDVPNEYTDIVACSMANYTWLETIMTVDERGLNVDGKKVRKNSLMRPTEGQPGVLTVDAEGVPSAPYAIVGTDYDNYACVHSCMGFMGFKAAFSWVFTRVPNPDRAYVALCRDLLAENGIEPSAMQPMRQGKDCPYTEKLDALLAYSKGVQSKAKAKEMAEDKKSSTKKTHQIEPINAVPQEATVTQESIGTIQSSVVSFILDEEKHLRELEHEMEEEERRLKHTMEMDHRREEEEIEEIREEVIYENRRHRHEGGHRAEHAAGGGEHVHLSSLAFVLPVVSLLLPSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N391</accession>
    <name>A0A8J5N391_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ATG9A-L</name>
        <name evidence="12" type="ORF">Hamer_G020116</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Preautophagosomal structure membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010583">
        <property type="protein sequence ID" value="KAG7172558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N391"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="546"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="765"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7172558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="818" mass="93211" checksum="A5A748A1D7DE39F5" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3F0</accession>
    <name>A0A8J5N3F0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MARS2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3F0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007999">
        <property type="entry name" value="DUF745"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37161">
        <property type="entry name" value="HDC10475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37161:SF3">
        <property type="entry name" value="HDC10475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035168616" evidence="1">
        <location>
            <begin position="18"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="267" mass="24921" checksum="769438F491E5D117" modified="2022-05-25" version="1">MINTFLTLCLCLGVVVADTMTTEVTREKRGFQGGGAGGDYGGGSGGGGGYGGGAVSGGGSYLIVGGGGGSHGPRAADIANQAAAQATAAAAGLGGAAKSAASAAAGQAAAAASAASQTAQAAAAQKHAQAAQITQAAQGAQAAAFAESALAGRASQAMQAAKITSSSASGLLATLGYVTAEANALASQAANSLAAIQAFLDGQQAMAWQAQQAANSLNQQQSLVLNDLQSTQAAAAQAQAAASKALAKAKGSGGGYGSGSGGGGYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3V2</accession>
    <name>A0A8J5N3V2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chaoptin-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">chp-L3</name>
        <name evidence="5" type="ORF">Hamer_G017882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010216">
        <property type="protein sequence ID" value="KAG7172903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3V2"/>
    <dbReference type="OrthoDB" id="1111193at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7172903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1195" mass="136536" checksum="FE9AD5F3F65B8C59" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4W5</accession>
    <name>A0A8J5N4W5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heparan-alpha-glucosaminide N-acetyltransferase-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Hgsnat-L2</name>
        <name evidence="2" type="ORF">Hamer_G014617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010116">
        <property type="protein sequence ID" value="KAG7173292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4W5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061:SF24">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="497" mass="57049" checksum="5664BBFCB36B9FAF" modified="2022-05-25" version="1">MSLVDSSTTTCGTGDHLKHLTLGEACLEVSNSDPVNNLQLWAQAVECYKCPPWPYLTLAPTTSQALVVNTTYPTELFIRNKDGSDLHTFFYHFGEYGTYQLGINTNNVTQVKILHKAQNEFLPLITAAIFFFMLVFVWQCAKFLVRRMNVPCSPRAVRSHVVDEHSPLLVAASGSESSPSTSQIAIVVMIFVNYGGAKYYFFSHARWNGLTVADLVFPWFMWIMGVSLIFSVRSQLKRTTKRYRMVLKILKRCIILFALGLFINSENGHNYIPTFRIMGVLQRFSICYFITALMEVYFMNPQESPEYVWYWKIRDIVRSGVQWVITVVLVVIHSVITFSLSVPGCPTYSWEQQQDASLSPTRTMDHVLNAGWLGELLGMLAGFICGWRKEGGPIPVNKNLWSLSFVLTTACFAFLLLSFLYLVIDKWKWWSGNPFRYPGMNAILLYVGHEVCNGLFPWFWEPVKQYHAYFLLMNLWGTSIWVIVAYLCHRRKLYISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5S2</accession>
    <name>A0A8J5N5S2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G030544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008145">
        <property type="protein sequence ID" value="KAG7174021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5S2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="157" mass="17847" checksum="F564C395DD4F72FF" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5V8</accession>
    <name>A0A8J5N5V8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phospholipid phosphatase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PLPP2-L</name>
        <name evidence="9" type="ORF">Hamer_G022737</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008788">
        <property type="protein sequence ID" value="KAG7173827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5V8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF103">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE HOMOLOG 1.2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="115"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7173827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="325" mass="37541" checksum="BB5350305996DFDA" modified="2022-05-25" version="1">MTSESTEDEARKKSQRRVVFLQTHKRRIGWAFAACLVVTLLGIVPPSHTVISCADPTIRMNYQFDTIPVSMLVCISLFLPFFVMMVMEWALPPSSVVLGTSPFRSGLRRGWSYTTDLFVGGLFMYFINDVAKTVTAEARPNFWDSCRPNITEEHCQQNQIERVDESSLVEVPYEFNPQDSQRVYGFIFKLLAEKSTGVYIKQRLWNRCSLLLAPWLQLIWAVWTLICCQSRIWDNKHHWWDVLGGGLLGAFGAFMTLHYLSNWFIREDDLDKPSSRDLPFHCQEDRSSGFSRNSVKRLISNTSDTDNHSDLRHDDRELRDINGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N648</accession>
    <name>A0A8J5N648_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lin-54-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LIN54-L</name>
        <name evidence="6" type="ORF">Hamer_G018660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009960">
        <property type="protein sequence ID" value="KAG7173378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N648"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005172">
        <property type="entry name" value="CRC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028307">
        <property type="entry name" value="Lin-54_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446:SF34">
        <property type="entry name" value="PROTEIN LIN-54 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446">
        <property type="entry name" value="TESMIN/TSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03638">
        <property type="entry name" value="TCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51634">
        <property type="entry name" value="CRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRC" evidence="5">
        <location>
            <begin position="648"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="608"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7173378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="872" mass="91841" checksum="A27347B865741639" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8B8</accession>
    <name>A0A8J5N8B8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear pore complex protein Nup160-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Nup160-L</name>
        <name evidence="2" type="ORF">Hamer_G026078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004741">
        <property type="protein sequence ID" value="KAG7175700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8B8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="1">
        <location>
            <begin position="128"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="201" mass="22044" checksum="B10946F17B0CBEE2" modified="2022-05-25" version="1">MTTPGGGSAVSDNLVVAVLFSDPGAAVLQLLVVVLFSDNSWWWQCCSQTTPGGGRVLFSDNLQCCSQTTPGGGSAVLRQLLVVAVLFSDNSWSHVSVSLLGAAQSTLQDIKVPEYGGGYTFTPLSHNRCLFWRVCHDVVELWEESLDHDFCHNHVQLRFADTPVLEGLSVHETRQYVYILLATVSSVHRIRLPHPHTTQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8D4</accession>
    <name>A0A8J5N8D4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spondin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SPON2-L</name>
        <name evidence="7" type="ORF">Hamer_G015717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007499">
        <property type="protein sequence ID" value="KAG7174593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8D4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000026">
        <property type="entry name" value="Spondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF15">
        <property type="entry name" value="SPONDIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Spondin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7174593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="394" mass="44366" checksum="051AA7B14C358AD4" modified="2022-05-25" version="1">MAECGIGNTELGVVLGHCGLGGIGTLSWVWCWGTVDPLDAGTDNGLTFTSPNWPTSPAERIFRITSKYPDHPAHSFYYPTLHHLPRIATFTISKTKEYTLSEHMDAATHTAYDVVKLEDIAYKHFGDEASTGSESRGARNGDRQDDNRIKNRVSYVTSVRTFTPRVTTSPTTTTSISTTPMPTTTSASPFHAHHRHHRPQGDPYPTPVWPEAVTEPGVHNSLENAIPPPKTAVPSSRRISVMSNSVEAEEETEEEETILEEEDQAIQMGSKKDLGSITQNRIPSGNAMAVIDDIVKNYQKEQRKKRRKQRRKQRREERRKRRNGLKKIRPPRDCRVSEWSEWSPCSKTCGIGEQTRTRTILKHARRGGKVCPVLDETTWCGSARACPRNYFNWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8R9</accession>
    <name>A0A8J5N8R9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative vegetative cell wall protein gp1-like 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005502">
        <property type="protein sequence ID" value="KAG7175570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8R9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="422" mass="47214" checksum="E4FCF41867957665" modified="2022-05-25" version="1">MMMMTTTRVLTHTDRQTNTDRQTDRQIDRQTDRQAGPKRVRYHILIVQGGKIFFPDSPEAEGLSATPSDTREERGLWESDLFFLQKLSGLFGSDDKPQRRKATTRPNLRPELLPPQFLYHNRRTGTKNPGHLNQVGVRQVTRVPVRSPPHLPSPHQGFQVFGRPLPNPQGLKPPPPRQNVHVITPSTQNVPPPPDSLSQYSHNQQVAFRPPPPLPVPPKLPASVSPVQSPVSFPYQFVRPGTHLPDNNNIPHRPTANFPPRVNAPQPNLPPRPISLPANFQTRVTVPPRHNSPHSPAPRPPPPAKPVKSKKPTLLGSWADFSNGVFGNTGRPQKHPRPAPQPQRVIIPPHHKLTQKKDFKPSLEFKPSPQEGNSAFDAFQPVFVASPFMDDLSDDVMKPMRVAALRTPATTTTSQPILQDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N916</accession>
    <name>A0A8J5N916_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Aspg-L1</name>
        <name evidence="7" type="ORF">Hamer_G015278</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7175058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N916"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000003">
        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="5">
        <location>
            <begin position="46"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="6">
        <location>
            <begin position="218"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7175058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="574" mass="63126" checksum="F0CBF8631734F978" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9Z9</accession>
    <name>A0A8J5N9Z9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FRA10AC1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Fra10ac1-L</name>
        <name evidence="4" type="ORF">Hamer_G009129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">GMGI-L3</strain>
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    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="1"/>
            <end position="21"/>
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            <end position="886"/>
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            <begin position="130"/>
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            <end position="851"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </feature>
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        </location>
    </feature>
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        </location>
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    </feature>
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        </location>
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        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="66" mass="7288" checksum="4CCCA0CCC3EEBBB7" modified="2022-05-25" version="1">MVVVLASCGDYASVWDSASLSSGASYAEIVDSQSLCIMHQSIQTLKYYSNLNKVTDVHSLWEDDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDN3</accession>
    <name>A0A8J5NDN3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Replication protein A 70 kDa DNA-binding subunit-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RPA1-L2</name>
        <name evidence="3" type="ORF">Hamer_G016668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002318">
        <property type="protein sequence ID" value="KAG7177384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDN3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="186" mass="20768" checksum="20F89BB2C9D3A871" modified="2022-05-25" version="1">MTGLCTGVIADIIEGAHPENPILQVLSMKRLPTESEERYRLLVSDGEWSSNFAMYARHPNSKVTKEEITKNCIIQMNRYVCETVQENKKVLIILELKLERTGEDVGLKLGDPVNYDPSKPRTQQQPKQQQRSQPHLPTPSMRATGGTPQRNLLGDHNPFKQGISPSKSPTGGNVHPICSLTPCQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDZ5</accession>
    <name>A0A8J5NDZ5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Immunoglobulin V-set domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G008373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDZ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF15">
        <property type="entry name" value="BEATEN PATH IIIA, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035287545" evidence="1">
        <location>
            <begin position="27"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="41"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="204" mass="23108" checksum="7C57A5B5D84052E3" modified="2022-05-25" version="1">MVGWLYNTCLQRLYLLAVLFFNSAAGDLLRGVEVPQFAVAGGQARVSCFYDLRTTKLYSLKWYHNSTEFYRYVPTERNRAINIKPTHKFSVAELFRNERQVSLSLTKLAIAATGHYRCEVIAEHPSFRTEASTASMTVAAAGGTLKAECRMTLGTFTLSSFKTLRVRVRLISYVGTYQSPANQWKARIMLTSVMVFIPVHFNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NEF4</accession>
    <name>A0A8J5NEF4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001826">
        <property type="protein sequence ID" value="KAG7177789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NEF4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="255" mass="29061" checksum="B890A63848C4AEED" modified="2022-05-25" version="1" fragment="single">MIVLLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQKTKAEGQGSMQMGSIDYSETKKQIVNAKKREQIREREQKKKMKSEEAIQREEELCQDLGDCSFHSRKVPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKGTPMQVPKWPSHTQSVERCAKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T7E3</accession>
    <name>A0A8J5T7E3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Triokinase/FMN cyclase</fullName>
            <ecNumber evidence="3">2.7.1.28</ecNumber>
            <ecNumber evidence="2">2.7.1.29</ecNumber>
            <ecNumber evidence="4">4.6.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TKFC-L</name>
        <name evidence="19" type="ORF">Hamer_G025445</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>FAD = riboflavin cyclic-4',5'-phosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13729"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:76202"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.6.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Interacts with IFIH1 (via the CARD domains), the interaction is inhibited by viral infection.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.28" evidence="3"/>
    <dbReference type="EC" id="2.7.1.29" evidence="2"/>
    <dbReference type="EC" id="4.6.1.15" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010009156">
        <property type="protein sequence ID" value="KAG7173639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T7E3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034012">
        <property type="term" value="F:FAD-AMP lyase (cyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000002">
        <property type="entry name" value="Dihydroxyacetone kinase, L subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="18">
        <location>
            <begin position="8"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="17">
        <location>
            <begin position="348"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG7173639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="519" mass="54380" checksum="79F7E9E58FB1B39A" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T917</accession>
    <name>A0A8J5T917_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Glutamate receptor ionotropic, delta-1-like 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Grid1-L30</name>
        <name evidence="17" type="ORF">Hamer_G020129</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009549">
        <property type="protein sequence ID" value="KAG7173506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T917"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035277265" evidence="15">
        <location>
            <begin position="25"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="576"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="775"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="16">
        <location>
            <begin position="289"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="64"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7173506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="796" mass="88925" checksum="95A00D052E3F33F5" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TEU7</accession>
    <name>A0A8J5TEU7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TEU7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69349">
        <property type="entry name" value="Phage fibre proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="87" mass="11080" checksum="B274B2FEA3DCD3EF" modified="2022-05-25" version="1">MIQHAVPDYNRQYTMIQHEQYTMIQHEQYTMIQHVQYTMIQHEQYTKIQHEQYTMIQHEQYTMIQHEQYTMIQHEQYTMIQHEQYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIT0</accession>
    <name>A0A8J5TIT0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIT0"/>
    <dbReference type="OrthoDB" id="5959877at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361:SF2">
        <property type="entry name" value="DUF885 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="GLR0591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="173" mass="20205" checksum="9B18B50338A23A4E" modified="2022-05-25" version="1">MSVSEFSEMVRKDAQFLYDNPEALFKDFEDLVYNVIPLKLPEVFLNIPKAKLKMERLSSPHSTTAFYSVGAYDGSRPGVYFVNTFHCDSQPKYEMMTLSLHEGNPGHHLQGSHSMESPKIPFFRRVMEDRNYWQAPSRFPINTAYLEGWGLYAENLGFDMDLFKNPYIRHIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TMT0</accession>
    <name>A0A8J5TMT0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G001499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TMT0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="106" mass="11986" checksum="C90AF7FDE5D36465" modified="2022-05-25" version="1">MVRERKLHLHPLKMVIVVEIVWLLVMVVVVTCRTEIVSEITGAPTTPLTGKIVTSITRHYQGDVYSLTVFNSTENDTENDTENDTENDTENDTENATENSTEDLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JAH4</accession>
    <name>A0A8J5JAH4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cuticle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G015036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JAH4"/>
    <dbReference type="OrthoDB" id="6375705at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF238">
        <property type="entry name" value="CUTICULAR PROTEIN 65EA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035325132" evidence="4">
        <location>
            <begin position="16"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7154680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="266" mass="27243" checksum="EBF1094E48C487E5" modified="2022-05-25" version="1">MNMLILSCLLAVAAAAPQYNYGAPAPAPSAPASYSVRSPPVEILRSDRQGPDATGAYSFLFESADGISRQEQGAPQGPTGAVASQGGWSFTYPDGTPAVFTFVADGAGYRVQSDLLPTPPPLPAHAIAQIEKARQEDAAAASEPRNSYSAPAPAPAPINTYSAPAPAPIISYNDPAPAPIISYSDPAPAPINTYSAPAPAPIISYSAPAPAPIISYSDPAPAPIISYNDPAPAPIISYSAPAPAPRNSYSAPVPAPAPQTYYSYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JAZ5</accession>
    <name>A0A8J5JAZ5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cofilin/actin-depolymerizing factor-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Cadf-L2</name>
        <name evidence="2" type="ORF">Hamer_G020083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045843">
        <property type="protein sequence ID" value="KAG7154019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JAZ5"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="1">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="147" mass="16785" checksum="15FA9265652416F0" modified="2022-05-25" version="1">MASGVNVADGVQQAYAKIKTGMKYRFLIFYIKDDKEIDVEKFGEREAQYDDFLNYLASLGPDKCRYGLYDFEYEHTFQGTSNTKMNKLVLMSWCPDTAKIKTKMLYSTSFNYLKQALEGIGKCIQATDMSEASYESVLEKCSASDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JB07</accession>
    <name>A0A8J5JB07_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G024813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045833">
        <property type="protein sequence ID" value="KAG7154034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JB07"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="103" mass="11292" checksum="88E84513C15BF1F5" modified="2022-05-25" version="1">MYVLVASPRYDGLVTPPRCNVLVVPPRCDVFVTPPRCNVVVASSRCDVFVTPPRSNFLVASPRYDGLVTPPRSNVLVVPPRCHVFVTPPRCNVLIASPRCMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDV7</accession>
    <name>A0A8J5JDV7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Gamma-aminobutyric acid receptor subunit beta-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Gabrb-L7</name>
        <name evidence="16" type="ORF">Hamer_G017750</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046276">
        <property type="protein sequence ID" value="KAG7153925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDV7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035212136" evidence="14">
        <location>
            <begin position="21"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="693"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="724"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="756"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="820"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="15">
        <location>
            <begin position="222"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7153925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="841" mass="95856" checksum="695FFE850CE7F709" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEH8</accession>
    <name>A0A8J5JEH8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phenoloxidase-activating factor 2-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PPAF2-L12</name>
        <name evidence="5" type="ORF">Hamer_G022584</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040186">
        <property type="protein sequence ID" value="KAG7156046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEH8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF129">
        <property type="entry name" value="LP15124P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="3"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7156046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="326" mass="37002" checksum="9CFDD2DB50EA07F7" modified="2022-05-25" version="1" fragment="single">ARILGFQEGESQFGEFPWVAAVLRVESLSGLKLRRFVGGGTLIHPRVVVTAAHKVKGYNKSDMVVRLGEWDTQSEQEPYRHQDVAVDDIVLHPGFVLQTLYHDVALLILKEESKFASHIDSICLAQDLSLVDPSACVINGWGLSGFENGEYQRIMKSLTLPLVQYKDCVNSLRTTRLGRYFRLHPSFTCAGGEKGKDACRGDGGGPLACPRKEDPKRYLLVGITAWGIGCGQDGIPGVYNAAANDSEGSEVEGRSDTEAITREENNQGRQHGAKEQRLEKRKQQREERERRRQEKEESREERRRLREERQRERLEAKEIRRRNRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JF66</accession>
    <name>A0A8J5JF66_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor RFX4-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Rfx4-L2</name>
        <name evidence="5" type="ORF">Hamer_G020318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038254">
        <property type="protein sequence ID" value="KAG7157032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JF66"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035153864" evidence="3">
        <location>
            <begin position="43"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="4">
        <location>
            <begin position="70"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="4">
        <location>
            <begin position="612"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="4">
        <location>
            <begin position="719"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="825"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="895"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="957"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="965"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7157032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1201" mass="135790" checksum="C07E9AD0DC9996B5" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFD9</accession>
    <name>A0A8J5JFD9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042215">
        <property type="protein sequence ID" value="KAG7155283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFD9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="459" mass="51725" checksum="78EF1F71004F3BE3" modified="2022-05-25" version="1">MRIITRRRVKVRVTVRRGDGSVTSHGWAFHRKRDEDGHERKQGESGDDEGVTPKEAQSAAGEPPPPTPDSSHYDTVCDDRDLDVELEEDADYEDAHYEDTKGSGIYENLDKDSERIYEEVGKKGLRVRFEGDNNEEDGDDGSLYSTGAIPKRGSTSTLTEEEEEEEEERGGKEVEEEQEQDDDGQIYETIGEFRQSTEPKDPTRDDRKGETLTRESETYIYDEPRKIEVTVTSKREGDDFEDRKYNSDKPKGKKRGKVEVKFTPWQTEGRGQRTKIINDKCNDGDENLKVEQTTKFSCCDGNGSRHKTGDGDRGEMGSPYELHHRSKIEVTSENMSDGGCDGGDDGDAGGNTTKNKKSSCGHQCVDDDNDDDDLDDDDFGDDESTIYQRGRHRVKKRTLIRVRGVGVDMDKNQDLEAAGRALVKTFTKTIVTFGRGLFTYVSVSHHCYCRTDAPKSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFI0</accession>
    <name>A0A8J5JFI0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G010024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFI0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="209" mass="22998" checksum="4660212D80417BB8" modified="2022-05-25" version="1">MAAADEYSTTSHVLQLCLALQDRLEKVEKEVQSLKGEILALKLVLEEKKTFASVVKDGEVEVDSWKVVAASATKCTLKRHSAVDLNNRFSTLSDECEEGASNTTSATPSVSVERGSSAGAIQMTHKLLNICDIPISTNGVQQEWVVIEHLPALIFTIITEGQDCVTPGRSAQHPHFSDLGTNEVNQQHHYISVFTRYQYFFMALGLCIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFP5</accession>
    <name>A0A8J5JFP5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myosin light chain kinase, smooth muscle-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Mylk-L1</name>
        <name evidence="5" type="ORF">Hamer_G005753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFP5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF7">
        <property type="entry name" value="TITIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="36"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="164"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7157337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="239" mass="26609" checksum="0C7E31AE10E7F027" modified="2022-05-25" version="1" fragment="single">EQDVMDEGRYKVKTEKGSTSLTICDVVSDDCDKYSAPEPPAAKPNRSEVTADSITLSWYGPTFDGGSVVMGYTVEARKAGSDDRYTLISGCHLTSYIARGPKKNCQYEFRVRAQIVHGLSEPSKPSTPVTTADPVEEPEPEDHETAFAPLNVEIEPGSLFDKQYSLHEEVGKGRFGIVYRVTEKNSGVRRTAKIIKCIIAKDKEKVCEEVDITNSLRHPKLLQLGAAYERQREMVMVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFY7</accession>
    <name>A0A8J5JFY7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Neuroparsin 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Np6-L</name>
        <name evidence="7" type="ORF">Hamer_G012119</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFY7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005520">
        <property type="term" value="F:insulin-like growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000867">
        <property type="entry name" value="IGFBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011390">
        <property type="entry name" value="IGFBP_rP_mac25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14186:SF20">
        <property type="entry name" value="CYSTEINE-RICH MOTOR NEURON 1 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14186">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00219">
        <property type="entry name" value="IGFBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00121">
        <property type="entry name" value="IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51323">
        <property type="entry name" value="IGFBP_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035246744" evidence="5">
        <location>
            <begin position="26"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="IGFBP N-terminal" evidence="6">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7155969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="136" mass="14665" checksum="926244F89C5B5A7F" modified="2022-05-25" version="1">MTTAAHLRWTMLGLLTLTFFTASAAVTAVRPEALQCRPCNPNRCPAIGECHRGITWDVCNCCEVCAKGLNEECGGPWSAYGKCGFGLTCLKDARECPYLFHPRGSGADTGSNICDEYLFNGNILSSNLAIVSFMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHL5</accession>
    <name>A0A8J5JHL5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine-protein kinase ATM-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Atm-L</name>
        <name evidence="4" type="ORF">Hamer_G022144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040691">
        <property type="protein sequence ID" value="KAG7155740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHL5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="133"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7155740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="282" mass="30872" checksum="B7E04797300A50D7" modified="2022-05-25" version="1">MCQEHPHHCLPVIIAQAHAHADDELVRIGSKSKKQENQVVEEDRVQAAKMLVHRLSTSAIADNIIEFQKVSLAYISLAAWCDKGTKCPAGNKVKIPSNQILVKLQNLKYTAALTRPLQLQPSTIYTPSLIVGWENICTFVGGINAPKRLTLRTSDGLKQYELLKGNDDIRQDAVMEQVFGIVNELLAKNSETRERALSMRTYQVVPLSQKSGLIQWCDNTQDIVDGLGVMGVEGPLRQCCEATLSVLRSSGEVLVTVVEVLLMTLAPVDSVTPASGSSSGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIM4</accession>
    <name>A0A8J5JIM4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Paired domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIM4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12371" checksum="4F8A66D2F7CBD7E7" modified="2022-05-25" version="1">MSRMVTTRDDIAAVIALYKANHVLREISAQTGVALRVVQNLVKRFRDLGEEEFPAPLPKSGRPKLLSPRTLKDISRQVRSNPSLTAREVKERKPSYESRLVTLCSTSPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKH9</accession>
    <name>A0A8J5JKH9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">5-hydroxytryptamine receptor 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HTR4-L</name>
        <name evidence="11" type="ORF">Hamer_G021245</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033646">
        <property type="protein sequence ID" value="KAG7159300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKH9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7159300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="379" mass="41211" checksum="CD5F59A1EEC7411E" modified="2022-05-25" version="1">MYVLNDAPLLPEDSDHKMMPLLMESPQCVLFGTFMIWFASITINLGPTFLSGALAANIDEEHNAPSCPLITGPLRHYVLNVLWIIINVLVLLLTVYHLYKLYRDLSTSSLEAVRIASLVTTMISVTQPQNQDPESREHHQVNNYITRMEREGVERVKMFVVVTVAYVVFWGPLFLVTLLTPSGGKTGLSHEVTLHVAYVHAFVNPALFLALHKGLRKAVTDIMCCHCSSHDEQTNRAEGLAGLQPNMTTSRSSLGGGLTGVLGGPMSASGALSGGLSTSGLSGATALSTAAAQAMPPYSSDGTEQISIPQHQLLAYVSKLLPSLPPPFYYIPKSCDLLRYIVVQLLDPQIQRGEQFPEQPTGFPPGSDLTTPPTYGHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKY1</accession>
    <name>A0A8J5JKY1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposable element Tcb2 transposase-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Tcb2-L5</name>
        <name evidence="2" type="ORF">Hamer_G004221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKY1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="41"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="126" mass="14055" checksum="08A7DEC0E257C33F" modified="2022-05-25" version="1">MFGWMHAGSVGQLADVGPGRFTGQKFVEELGDVLLPSVEALFFQQGEPFYLVQDNSPIYTCHAVREWFGRHPYITLLPHPPRSPDLNPIEHVWSAMNKYNIPSAGRHLIRECPHPCLGGMGAATRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JL32</accession>
    <name>A0A8J5JL32_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AATF-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">AATF-L</name>
        <name evidence="3" type="ORF">Hamer_G004079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JL32"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="2">
        <location>
            <begin position="199"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="350" mass="39386" checksum="54B76E4EB7BB6952" modified="2022-05-25" version="1" fragment="single">LDDLLFTSLRRGGEYCLPHGGVVLLSVITSWPYITPRSMASDLKSYVEKYLLNPAASFSVDDDGNQETKAQVVDALAEEERADSTRQPVSKLRARSAALQAIEEDDEGSESEDDTIKKIHKQLKKEPEGVTFVDDGDFSKFADDMDEEDDEGDDDEDDNDDDDEGDDDEDDEGDEDMEEEADGQEDSLKKFSIGDQCEEVKKGQAVKNQLAIYDTLFEGRIGLQKVVTGTNQLPQYDTYKKFVQECDPHYNKNLITAKSAAKNLLNSLLNVQELLLRQNSETSYIITGKKPKHLGTDSDEEVTSSEEEEEKEVLLNSRGTKRKMKLEEYDEVLSKRHAAMVPFRDQAVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLD0</accession>
    <name>A0A8J5JLD0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G021553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042144">
        <property type="protein sequence ID" value="KAG7155289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLD0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000017">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="486" mass="55705" checksum="0EF30A0FCA7B5FE0" modified="2022-05-25" version="1" fragment="single">MNERWCVYLLVIVTNITFVYYLGLLDGALAPVSIPKPCGIACSVEESPHFLIHTPGCVIPDFDPLDPTISKYRTTENKTVVCSTRRPLTETQGLLLVVYKERAVDYGVTWESLNCSYRGIKRIQQNPVKLHEVIPIKEESAIVDEDGILVTCQEETNGTNTVYKNVHYFVQPRVVRDKRKKFQEDHGERRPRQDPLSVIVMGTDAVSRGNLRRHMPETFDYLKKSLGAIDLHGFNKVADNTDPNMIAALMGLTEKEFKNHPCVPNKMSKFDDCPLIWKNYSENGYATAYGEDSPWMGLFHYNRAGYVKQPTDYYNRASFLISEREISHNAGLGKSNGRYCQGSKLSASVVHDYSLLVADALKDIPYFGFYWTASLSHDYLTMAKAVDRPSLWYLQQLHSRGYLDHTILFFISDHGQRWGDFRSTYAGMLEERLPYVMIVFPPWFKDQYPEAWANLHTNTRRLTSTFDIHVTLRDILTQAYTDLSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLN8</accession>
    <name>A0A8J5JLN8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031186">
        <property type="protein sequence ID" value="KAG7160632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLN8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="82" mass="9031" checksum="9D125550867A3922" modified="2022-05-25" version="1" fragment="single">EKGATEQTPAATVHETNEADKAKSQRIETSTQSTAERQDLQNNIQRETGAVRKKVSTATMDTQGEKTLLTLECADDCELQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JM88</accession>
    <name>A0A8J5JM88_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 50 kDa gamma-zein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G024722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040902">
        <property type="protein sequence ID" value="KAG7155709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JM88"/>
    <dbReference type="OrthoDB" id="6370827at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7155709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="149" mass="16154" checksum="B03C74A3995CCC13" modified="2022-05-25" version="1">MSPSQQHSASPSDNSNTIGGNSNSRSTSKQVRYKGLFTPQVAPTTRAYCLLLSFLLGTLMLTAGSVFYHVIQSKPMSGSHPMHTPPLPLALFLLAAGIATLLSCFTVAWKYGFDDGDESLEEDLYSFAKDDVLDQQYSSTCETPKDPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPK9</accession>
    <name>A0A8J5JPK9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch domain-containing protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Klhdc4-L</name>
        <name evidence="2" type="ORF">Hamer_G027651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028841">
        <property type="protein sequence ID" value="KAG7161670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPK9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="172" mass="19434" checksum="643007A58FE7556A" modified="2022-05-25" version="1">MGKKDKKKGKGAEKTAIKTEKKTTQKIKKELAAKGEEDIGALLAKFAEDDKSKLAVTEDLVPPPSKRSSFSLTPHPDRDQLILFGGEYFNGSKSFMYNDLFFYTIKQNRWHKVTSPGSPPPRSGHQAVALSQSGGQLWIFGGEFTSATQSQFYHFKDLWVFHFSSKRWEKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRJ8</accession>
    <name>A0A8J5JRJ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7162915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRJ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="70" mass="7975" checksum="AECA3657098DA9D2" modified="2022-05-25" version="1">MITVVVNKLQLMCEFRELAKAMEASIHRWGTPKARRGSEKIKFRNFPSGSEPDERKTAGEAEEASCYHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JS79</accession>
    <name>A0A8J5JS79_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G019676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029207">
        <property type="protein sequence ID" value="KAG7161486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JS79"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="56" mass="6681" checksum="F04C77FDFBD25CCC" modified="2022-05-25" version="1">MYEKINYWKGDERGWEGLLDGGGDGWHETGGFGMDGWVLCGYKWDWEQEWVWVVCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSS0</accession>
    <name>A0A8J5JSS0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vigilin-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vgl-L2</name>
        <name evidence="5" type="ORF">Hamer_G002681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSS0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="38"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="117"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7163497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="192" mass="21394" checksum="C43BAB15940F17B1" modified="2022-05-25" version="1">MSFKNNSAERRQVNMTKQEKSRPLPPSLSRMRAQWVEETAMETVQAPNCLLGIVIGPGGSTVKKIVDQYKVQVRVPHKGSKDEPILVEGKNKTLVKEAALHIKAMIDEEKERRRVTTPVSRTLFIPKALHGKIIGHRGQNIRPIIQSLKINIVFPKKNDNNDKVSITGLPNQVDQGIGHLLSLVTSFPPCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTH2</accession>
    <name>A0A8J5JTH2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">UBX domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">UBXN4-L</name>
        <name evidence="9" type="ORF">Hamer_G023009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030986">
        <property type="protein sequence ID" value="KAG7160708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTH2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16117">
        <property type="entry name" value="UBX_UBXN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="UBX" evidence="8">
        <location>
            <begin position="362"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="482"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7160708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="555" mass="60957" checksum="38D7C3504AAB6AC0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTM1</accession>
    <name>A0A8J5JTM1_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Hamer_G014396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026055">
        <property type="protein sequence ID" value="KAG7163947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTM1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="183" mass="21334" checksum="F73C50CD86334B2F" modified="2022-05-25" version="1">MRCLCAAWRPLWPECVLQRDFEGFEELEEEAVVHEIVSLGNSMGLEVDDNDVEELVEEHSKELSTEELLELHKEENETLKRSLTSEESGEDEDKEESRIIPAKDLKDVFFCWSKLSKLVEDYHPDVGSVEKGINLESYKDDLVYYSDVHWLSKMLKRFYHLKDGVSTFMKMKGNPVLELNDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTN2</accession>
    <name>A0A8J5JTN2_HOMAM</name>
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            <fullName evidence="1">Pogo transposable element-like 74</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="primary">Pogo-L74</name>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTN2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="95" mass="10680" checksum="094E279C4895115C" modified="2022-05-25" version="1">MCAPELDVLCDFVIKAWNDINVETVIKSFKKCGISNSMDGMEDDMLWEDEDETEAEATSSDLELDPYDDAAINVSQDVLEELMISDVDDVDFEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUV3</accession>
    <name>A0A8J5JUV3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Y+L amino acid transporter 2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Slc7a6-L1</name>
        <name evidence="2" type="ORF">Hamer_G008067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF531">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="153" mass="17081" checksum="B39CA4157AE29F9F" modified="2022-05-25" version="1">MEGQMPEILTMIQIKRMTPTPAVLFMAFLSLIYLISSNIFALISYVGFATWISIGLAVLCVPWLRWTAPDLERPIKVNLVWPILYIIATIIITIVPMIAAPIETGIGVGIISTGVPVYLIFVKMRKPAFITTRLSKYCTVHVGYVSYRCVLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV38</accession>
    <name>A0A8J5JV38_HOMAM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G005096</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">American lobster</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JV38"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="73" mass="8042" checksum="CD300370BEBC6D5C" modified="2022-05-25" version="1">MTSETKNLMTSSTCLATAGCPTHTEPRVYSFDNKRPDGITLDPWKDGRQLVCFCLGTFLFPPQCNRSGEGSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV99</accession>
    <name>A0A8J5JV99_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G004763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JV99"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="63" mass="7081" checksum="EBFA6A98CE8431BF" modified="2022-05-25" version="1" fragment="single">MYTTRLEQLGTSISGRGVDVFLVFPWDVGPALRKACDHGADNDAIHQIRSASIVRRDMFKMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVQ6</accession>
    <name>A0A8J5JVQ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tigger transposable element-derived protein 1-like 208</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TIGD1-L208</name>
        <name evidence="1" type="ORF">Hamer_G004821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVQ6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="142" mass="16296" checksum="7FCFB9984A668182" modified="2022-05-25" version="1">MRCLCAAWRPLWPECVLQRDFEGFEELKEEAVVHEIVSLGNSMGLEVDDDEVEELVEEHSKELSTEELFELHKEENETLKRSLTSEESGEDVFFCWSKLSKLAEDYHPDVGAVEKAISVFNDNVMNYFWKPAIGPIPEAAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWL4</accession>
    <name>A0A8J5JWL4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase meng-po-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">meng-L6</name>
        <name evidence="2" type="ORF">Hamer_G002833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWL4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="413" mass="46527" checksum="7E7A03F2A08DC07B" modified="2022-05-25" version="1" fragment="single">ASTAASGHVVVAVLARSCRYQCNTRAALVISLDNTFITTTSPAVTLEMVGGSATVNFHNIKMLELPRMEVDCHFSDVRLLAENSGAKVYGARYLQSGTSVVLKCVQKEATKKKDFCRERHYNHCLSSHPNIVKCFDDTFETSTSYVLTQELTRVSDLSKFIMKGGVGEMRAKLVAEQVGQALEFMHKNDLVHRDVCSENIFVFSCELTRFKLGDFGSTQRVGAFVKKQKVRSPWAPPEVSLTVYNEGYLVDTAQDAWQLGILIFVCLTGSYPWSSADITDHHYNSWVAWLKRKTTKMPPRFKCFTPRLLRLLRRLLEPKPEKRSGVRELYKYLSDPWLMDESNSFGITINAKLSQILSGSSKSLYSRAEEKLLDLVHSRLHHSDVRPPAGNKKRVRFSFDGEIWSPGDAVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JX08</accession>
    <name>A0A8J5JX08_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein P2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S acidic ribosomal protein P2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpp-2-L2</name>
        <name evidence="8" type="ORF">Hamer_G007712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JX08"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7160929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="99" mass="10191" checksum="81321C5A35D67F0C" modified="2022-05-25" version="1" fragment="single">FAATTLHVPSEKPHFKMRHIAAYLLAAMGTNQPTAATIKSILGSVGSALISSMPSCGGGVSSSIDAVAPAAAPAAEVKEEKKEEPEEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXE9</accession>
    <name>A0A8J5JXE9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000934</name>
        <name evidence="1" type="ORF">Hamer_G031300</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026137">
        <property type="protein sequence ID" value="KAG7163878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXE9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="196" mass="22157" checksum="9DF2412FED89BA8C" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JY01</accession>
    <name>A0A8J5JY01_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JY01"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="398" mass="46109" checksum="FF330DCF7E9B90D9" modified="2022-05-25" version="1">MTMFAGDMDYYHHNSPGRRHSLLDVTQTQKWRPRSNSMSVMDVTNFTPNISGLTNRRCSATPCTTPCFRFMRSVKRPTHYHSLTSDLDNLEVETGYAGHLTEALPSHEKEENFDVSVLLEDVDTDMQQLQSDGYLEEEDDGDAAKEPLHTIMSEELAEVKSPEARFTQKRRFMVVQGAYVEAEQQQQDVQEYPSEVEQVGLHSEDGSNVQEYDVQEYDVQGRFDGSRVQDDGSFVQQYGGQGEYMYVHQTGQTNVREGEEQNGRQPQDVIVDRQTSGQRNEEPGVQMMQNEGQIIQESLRDSQRARLRADHHHRQQHHHRQQEEHRNAKPRTGPEPHRRQERPSQHPREQSVRKINRGPLNRPQQMGGSRGPLETDRRPRQERLPPGVHPRRYKHAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZ55</accession>
    <name>A0A8J5JZ55_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent RNA helicase TDRD9-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Tdrd9-L1</name>
        <name evidence="5" type="ORF">Hamer_G011105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZ55"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF113">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="135"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="343"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7166276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="488" mass="55797" checksum="C156FCCBF1246FD4" modified="2022-05-25" version="1" fragment="single">MAEMPLSKFHGTAEDYLNWFNGVEFEKVVLPKSQTDGKGLQVPETEQDSCSFIDTSAYMDRKHGQDYAAKYKKEFEALPLVDTKQHSKVWSVEEDTMTESLLNEDGVNAAQVYLHYNFCVYNQDSTLPVFDDQKLFILDDAAEKNVHCNIVVTQPRKIAAISLARRVCTERNWVLGKLVGYQVGLDKRTDIDTRLVYVTAEVLVQTLINQRSLDKFTHIILDEVHERSAETDFAILLVKKLLRSVSPRVKIILMSATIDTFKFSEYFATPVTDQLVPAPVISIGKRTRHKIMTFYLEDLRVICRDRPTIIPKLPRINPGNPSIDDDMYKFVVEMISCFDILEENTEKMVTTRGAVLVFLPGLFQIECLIDHLGERAERYKWQLFPLHSSITHEEQQLAFSTQPKGFRKIILSTNIAESSVTITDIKYVIDFCLTKVLTYDSATNYTSLKMDWSSQASCQQKAGRCGRVSSGRVYRLIPQSFFRVGKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZ77</accession>
    <name>A0A8J5JZ77_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lactosylceramide 4-alpha-galactosyltransferase-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">A4galt-L4</name>
        <name evidence="9" type="ORF">Hamer_G011151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZ77"/>
    <dbReference type="OrthoDB" id="6333746at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007652">
        <property type="entry name" value="A1-4-GlycosylTfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04572">
        <property type="entry name" value="Gb3_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha 1,4-glycosyltransferase" evidence="8">
        <location>
            <begin position="236"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7166321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="367" mass="41730" checksum="35F33FD8B8F0DD7C" modified="2022-05-25" version="1">MSWKVVREKQVSMLLETVVVIVAVTFVLVVAAVYMVGDRTLLTSPIAYELVQVAEVKVEKSGWRSVMCTNQSTAPTPILAPLPKFSPSPEARNVFFLETTCAPGINAKMACAVESAARHHPAHQIHLALTNSFVRINDTFIQALSTLPNVRISTLDVDEVDKHGQFGKWLRQMKWAKGRWPEINLSDALRVGVVCSTGGIYLDLDMWIMGPLPDAESWLSREHQSQLTNSAFKLPKDHWFCEEAKKGMMGHFMPNVWGYNGPYLFQNTIKRFCHVKITPTLHSCRDLMFLDPALLFPIHYAVWEHYFRPNGNRRWKRPSNMVGIHLWNKLSSKRPLNPGDGSIVDKVAQENCPHVYKTLPETRQSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZI9</accession>
    <name>A0A8J5JZI9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G005647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022531">
        <property type="protein sequence ID" value="KAG7166531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZI9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035306301" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="10692" checksum="AAA9A8C5040BECE5" modified="2022-05-25" version="1">MLLLLLLLLLLSCTTSSQPRAIPCPPTPLPILLLPAPVVAAVASRRAAPVLWRTNNEAWPAHTCRWSPTFGCLLGPGSSVAAQDCERNDTYLRVVCVCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZP1</accession>
    <name>A0A8J5JZP1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Alpha-2C adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">adra2c-L</name>
        <name evidence="13" type="ORF">Hamer_G013614</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022272">
        <property type="protein sequence ID" value="KAG7166606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZP1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF189">
        <property type="entry name" value="ALPHA2-ADRENERGIC-LIKE OCTOPAMINE RECEPTOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="85"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7166606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="221" mass="24545" checksum="176DBCF1F2045F78" modified="2022-05-25" version="1">MDGLTVNLTAEVEDSAGFRDYGEAYDQEVEGFDSNASLALVNDTFNGTYWVYPWGNSMYPSGYSTLEIVIITVIITVAMIVVVVGNMLVIIAIATEKALKNITNWFIASLAVSDFLLGLVIMPFSLANLLMGYWMFGDLWCELHAAIDVLLSTASINNICLISLDRYWSITHAVAYLKKRTPERAAIMIVAVWLFSGLVSIPPLLGWKEVRDPEDFPRCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1A1</accession>
    <name>A0A8J5K1A1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vigilin-like 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vgl-L70</name>
        <name evidence="5" type="ORF">Hamer_G031609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020128">
        <property type="protein sequence ID" value="KAG7168285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1A1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="43"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="122"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7168285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="233" mass="26277" checksum="658114F612B18AB1" modified="2022-05-25" version="1" fragment="single">MQILNTNNGNERRAHRPANEGKKQKTRPLDPWVTRMRAQWVEENITESVKAPNSLLGAVIGPGGSIVKELQNCFKVRVLVPRKGAGDEPILIEGKHKNQVRDAALRVKQLIQNEEERRRVNTPVSRSLSIPKAYHSKIIGFQGQNIRHLTSSLKIHIMVPHKYDKSELITLTGLPQQVDQGVNEFPLNNTDLQNTAVNTSFETKVNCTYLGDYGEERSQARRGEVRIGDEMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1R3</accession>
    <name>A0A8J5K1R3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Failed axon connections-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Faxc-L7</name>
        <name evidence="3" type="ORF">Hamer_G013688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022272">
        <property type="protein sequence ID" value="KAG7166661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1R3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="2">
        <location>
            <begin position="178"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="328" mass="37613" checksum="A76401BA49093090" modified="2022-05-25" version="1" fragment="single">TGVVWTTCGLELSSNKAFVPTHGTQPGSALGFRVVKSWRSRCPGDWVRAAKLNLQQALNIRIPNAVLIFAFKLRYRQIGYFAVTTFVVPSINLAVPPLQTSMLHGCPFSCRVVKSWRTKNPDGMLGAYKMDLQRITEKRWPKLVLEFIFKLKFRRAAKKVRAHGIGVHKPEEIEEFGHNDLTVLSDLLGDKPFFFGDTPTSLDVVAFANLAQVAFMDKEVSYSLRDWMTENCANLVEFCSRVKDRAFPDWEEMCTNLDLNSHIPKPPPEEKVEEQAAEKKDEKTKEEDKKDEKEKDDTEKEKAQKDEKEGEKEDNKKTEEKEKEEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1W2</accession>
    <name>A0A8J5K1W2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sentrin-specific protease 1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Senp1-L1</name>
        <name evidence="7" type="ORF">Hamer_G011920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7165993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1W2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000001">
        <property type="entry name" value="Sentrin-specific protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="337"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7165993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="529" mass="60453" checksum="4CC18440C1F82B41" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2A2</accession>
    <name>A0A8J5K2A2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Macoilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Transmembrane protein 57</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MACO1-L</name>
        <name evidence="16" type="ORF">Hamer_G018366</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of neuronal activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Rough endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7167941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2A2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023041">
        <property type="term" value="P:neuronal signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019130">
        <property type="entry name" value="Macoilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47464">
        <property type="entry name" value="MACOILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47464:SF2">
        <property type="entry name" value="MACOILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09726">
        <property type="entry name" value="Macoilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="218"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="607"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="321"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="613"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7167941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="661" mass="73801" checksum="BFB1276FC8C35548" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2A6</accession>
    <name>A0A8J5K2A6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Autism susceptibility 2 protein-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">AUTS2-L1</name>
        <name evidence="3" type="ORF">Hamer_G002318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2A6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023246">
        <property type="entry name" value="AUTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14429:SF22">
        <property type="entry name" value="AGAP013055-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14429">
        <property type="entry name" value="FIBROSIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15336">
        <property type="entry name" value="Auts2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="582"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7168297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="635" mass="69316" checksum="F9040B824B3EBAFA" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2I9</accession>
    <name>A0A8J5K2I9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">March6-L2</name>
        <name evidence="11" type="ORF">Hamer_G011138</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2I9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7166308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="487" mass="53439" checksum="7858A8E58784E6F2" modified="2022-05-25" version="1" fragment="single">NEGELLHEGVPGNNNLDPGAAADDLNWNPIEWDRAAEELTWERLLGLDGSLVFLEHVFWVVSLNTMFILVFAFCPYHIGHFTIVGFKLKGWVSASHFEGLLTALCGYCVVGLCLVLLHTLAAIIRLNRSKRVLGLCYVVVKVALLSVVEIGVFPLIGGWWLDICSLSLFDATLKVRMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIVRHTRRFLASMVIFGSTVLLMLWLPIKIIHGLWPSFLPYHITLSSDTPVSELSLELLLLQVILPALLEQGHTRVWLKLLVRHWCAAVSHVLGLRSYLLGDVALDAQGGGVVIGGDTGGGVGEVGAGAVPQVELEEPADGIVNPVVGGGADALAGGLGAAHQALLQRDGPTGFQAYVRPRWFGVRILGLIIMMCISLTAASIMCLTLPVLVGRQCMYLALGDTKVSRVVHWCCSGSPLPVRDYPRHPTGLLIMLAGRRPKYCNGVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K371</accession>
    <name>A0A8J5K371_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane protein 184C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Tmem184c-L</name>
        <name evidence="6" type="ORF">Hamer_G022750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019676">
        <property type="protein sequence ID" value="KAG7168657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K371"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7168657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="435" mass="50344" checksum="9CA07BD58DADFD75" modified="2022-05-25" version="1">MCGERCRILCSQWRLWIRPLVFILYGGIILGFVPYLIYTMILKDMNGFEIAWLIGGIFVFLAIPITLWEIVQHLINYTKPKLQKHIIRILWMVPVYALNAWLVLKFPSLAPYLDTARECYEAYVIYNFMMFLLNFLDDEMDLDATMETKPQTNHFFPLCCLKPWRMGREFIHRCKHGILQYTVFHLMTTFIAFVCGQAGVYEEGKLSPKNAFVYLFVVNNLSQFVAMYCLVLFYKAMRRELDPMSPLAKFLCIKAVVFFSFFQGVAIMFLMKAQFMHDIFHIVAETEEERLKIERKDSSILQNFLICIEMFIAAVAHRYAFSYKPYVDEEYETGNCCHTFLLIWDISDVRSDIREHVYVVSEGMKRRLTSRGGGWPGGASAVGGVNGGDEHTRLIAPHAHTGSHTTQRYMSTSDSEHDIIIQQGEGSDTEDVKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3A5</accession>
    <name>A0A8J5K3A5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MPC2-L</name>
        <name evidence="10" type="ORF">Hamer_G014235</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025553">
        <property type="protein sequence ID" value="KAG7164109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3A5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7164109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="90" mass="10623" checksum="55DBB59FF0292D30" modified="2022-05-25" version="1">MAAIYRAIIRRADKFVPPKMQPFWNHPAGPKTVFFWAPCFKWRNCQSKSYTGVTQYPWYSLVIIPKNWNLFGVNVFVATTGLYQLSRIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K462</accession>
    <name>A0A8J5K462_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Cytochrome c1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CYC1-L2</name>
        <name evidence="2" type="ORF">Hamer_G020581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021277">
        <property type="protein sequence ID" value="KAG7167696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K462"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="177" mass="17793" checksum="0EBA5E0BBCCBB632" modified="2022-05-25" version="1" fragment="single">NEEKLEGYIASPHLSRRNCSETVVLSLAVVCFARPQAPTAEAPAEEVPTEVIAADPAANVIDPQFASFIFPDDEPAVVAAKMAHFAAVKVALGGPPATSQVAAETQAVEAEATLAAEAEGEAVAAAEAEAEAEAADAAALEAEAAEAQEAEAALADAEAAEATALEVEAAEAQEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K463</accession>
    <name>A0A8J5K463_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K463"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="74" mass="8271" checksum="F0BFF8BA9C4F87C1" modified="2022-05-25" version="1">MVQYGNVGYLTKQYGNVGYLTKQYGNVGYLTKQYGNVGYLTKQYGNVGYLTKQYGNVGYLANTATAAMRQYGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4Z2</accession>
    <name>A0A8J5K4Z2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trypsin-1-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Tryp1-L7</name>
        <name evidence="4" type="ORF">Hamer_G013546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4Z2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="330"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7170717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="537" mass="59267" checksum="87A27A18FA882931" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K624</accession>
    <name>A0A8J5K624_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G020580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021277">
        <property type="protein sequence ID" value="KAG7167695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K624"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="81" mass="9250" checksum="CF3A25493F330854" modified="2022-05-25" version="1">MTKEPPTSPGHQDYEHGYGLILDNGLRYFWRAWQDTGGNTQWMTSKRLKVCCWDEQNTTDVTWCVAGMNTTQQTSHGVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7A4</accession>
    <name>A0A8J5K7A4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018844</name>
        <name evidence="1" type="ORF">Hamer_G025481</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020418">
        <property type="protein sequence ID" value="KAG7168250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010018499">
        <property type="protein sequence ID" value="KAG7169073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7A4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="142" mass="15559" checksum="64D6D0005C614A6D" modified="2022-05-25" version="1">MENKIIMNIISKYGKVEGMRLNKYTKGQAAGLLNGTRTFKLKASVKEGDESVTVSQVPATTRYGVEGEQVPAQTITQDAVDPEGTTHPDCSENVVQETFTTCKAEILTERNNVDQTKGKISCENMEYDKADDMEATNMTGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7C0</accession>
    <name>A0A8J5K7C0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NFX1-type zinc finger-containing protein 1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ZNFX1-L1</name>
        <name evidence="8" type="ORF">Hamer_G011651</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000742">
        <property type="entry name" value="NFX1-type zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="1384"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="1440"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="1468"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="1495"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="1682"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="900"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1051"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7168963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2133" mass="243273" checksum="67D423AA1DFEC0AF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7V5</accession>
    <name>A0A8J5K7V5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphocholine phosphodiesterase GPCPD1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Gpcpd1-L2</name>
        <name evidence="3" type="ORF">Hamer_G012481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7V5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="293" mass="33470" checksum="95D52BF27AB17A0B" modified="2022-05-25" version="1">MVYHKKEQGLSRFRDEEFEDHQPFPTLQRALESVPYTCGFNVEVKWTMQTRDGTFELQHPFELNHFMDLIIKMILEYAGKRKIVFSCFHPDICTMLRLKQNRYPVMFLTQGISEVWPPYEDQRTTTIPHAVLYAVNADILGINVHTEDLMRDPSQLKMALDHNLIVFCWGDDNNDQENIKFLKKVGLHGIIYDKIDEYNTKEKKESIFLCEEREATMSTEQSDGTPVTNNNANVAPGPSGLATFTDMAIPATNGKAFKLPNPLSMTKSTNVGCTNSDHSQCCKPISFSGIFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K862</accession>
    <name>A0A8J5K862_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G021342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017879">
        <property type="protein sequence ID" value="KAG7169214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K862"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="304" mass="29425" checksum="2F8B6E321A4C3ACF" modified="2022-05-25" version="1" fragment="single">VVVCPIKAYQVVVCPIKAYQVVVCPIKACQVVLCAIKSHQVVLCAIKVYRVIVCTIKACKVVSESPPQQQQVGRLFKRQTTVGGTILLSVSAQAKDDCLYHRTIMNVTHWALALLLALMGVLTSVSAEPAPDPEPFKKRKGGHYYRPVIVMRSYGGGYGGGHGGGGYGGGKGKGGGIFKGGFGGGLFKGGKGKGGGGYGGGKGKGGGGYGGGKGKGKGGGFFKGFRGLFKGGKGKGGGGYGGGKGKGGGGYGGGGHGGGGYGGGGYGGGHGGGGYGGGHGGGGYGGGHGGGGYGGGYGGGGGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8K6</accession>
    <name>A0A8J5K8K6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013885">
        <property type="protein sequence ID" value="KAG7170562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8K6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="310" mass="34682" checksum="76938FB1F0FC6A62" modified="2022-05-25" version="1" fragment="single">SPSTLYITVITSPQHSEVLPHSYIWKIFTSLLHIIVSPSLTPTHHSESFPHSYTSQPVLPSLLHITASPSLTPAHHSQSFPHSYTSQIVLSSHLLLRVLPTLLHISESLPHPYTSQIVLSSPLHLSEPFRHSYTSHSTQHYKSFPHSYTTSILHNTTSPSHTNTQHYKIFLHSYTTLQVLPSILHNTKSPFLTHTPHYKSFSLSYTTLQTLPSPLHNTASPSPTPTQHCKSFFHSYTTLQALPSLIHNTTSPSMTHTPHCESFPHSYTILEILPSLLHNTAYPSLLPTQPSSPPLTLNNTRCPSLTSTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8V7</accession>
    <name>A0A8J5K8V7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0235 protein C15orf40-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G013453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8V7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420:SF7">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="116" mass="12227" checksum="8418741DE3380ADA" modified="2022-05-25" version="1">MLARNLGVTQSYRPLLVCNFFHINTASWRSPIMGKKKTKGNDPKEKAAAGSSEAGKVEGPITCNKSGNVVIRILAKPGAKDNGITDVSPEGVGVQIAAPPTDGEANAEDRAQDRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KFB6</accession>
    <name>A0A8J5KFB6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KFB6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="73" mass="8426" checksum="40E9E03038748131" modified="2022-05-25" version="1">MNASEVISRFRGRNSHMPGRPRRPKYHKGDKILPFCWSRNARWASGPMTVSHKSLSRQGRSLSQKIKVKIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLM9</accession>
    <name>A0A8J5MLM9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Mitochondrial import inner membrane translocase subunit Tim16-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">blp-L</name>
        <name evidence="17" type="ORF">Hamer_G012090</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLM9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF11">
        <property type="entry name" value="MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="16">
        <location>
            <begin position="190"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7155946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="394" mass="43467" checksum="3B449A45A7BDBEEB" modified="2022-05-25" version="1">MGWEPRKLLHIRMAKHIAQLVIAGAQVVGRAFAKALRQEIAASQAAAQRAGGGAAGAKHSATNQKLGMSLEEAKQILNVEELDLERIKKNYEYLFSINDKAKGGSFYIQSKMSMEGTWKRVGALAISPAGYSGLWARATESLIPVSTYPARQFATSPLTWDTVLSEANRKRCVSRMEKTIASRNFAHDPEKFAAVLIPMCHVDGELSLLLTVRCRTLNNHGGEVSFPGGMADVGDPDLITTALRESEEEIGINRSTVDIWGMMPPLPSKLGETSIRGVLAYVGHIDPSSLKLSEDEVESVFAVSVKSLCNSRNAKQTQFRSKRIPKGYTLPVYIGSEPRIWGLTAILIHMTLISLLPGLYKHKLIVRAKERIDLEMENVAEEVKKKEDRQETNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLY3</accession>
    <name>A0A8J5MLY3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spindle assembly abnormal protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SASS6-L</name>
        <name evidence="4" type="ORF">Hamer_G006068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLY3"/>
    <dbReference type="OrthoDB" id="49058at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10142">
        <property type="entry name" value="HD_SAS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032396">
        <property type="entry name" value="SAS-6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281:SF2">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16531">
        <property type="entry name" value="SAS-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle assembly abnormal protein 6 N-terminal" evidence="3">
        <location>
            <begin position="36"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="624"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="350"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="434"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7156338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="693" mass="76838" checksum="B1702805A27BEEE8" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMR0</accession>
    <name>A0A8J5MMR0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038152">
        <property type="protein sequence ID" value="KAG7157069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMR0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="70" mass="7927" checksum="54C7082DFBB33DBE" modified="2022-05-25" version="1">MSEVRNVNVVSGSGGNDGRKEGQQGKPQAKRDSRKGVKKRKYTLEMKQEMLEMIKSGARTCEIMHRFNCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MN36</accession>
    <name>A0A8J5MN36_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING finger protein 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Rnf11-L</name>
        <name evidence="6" type="ORF">Hamer_G019842</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
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    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UEC_component"/>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
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</entry>
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                <person name="Zimin A.V."/>
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                <person name="Timp W."/>
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                <person name="Greenwood S.J."/>
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            <dbReference type="PubMed" id="34162536"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">GMGI-L3</strain>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7158646.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="9099" checksum="9FF0D341709DC538" modified="2022-05-25" version="1">MAAASDMLITTQDEPGSLTTGRGSVQVYSLMSRDDHADGEALQERTGGRGEQRPTQKLKPLIFTNQSTASTSGSDVEARVNIKCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQQ2</accession>
    <name>A0A8J5MQQ2_HOMAM</name>
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        </submittedName>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Timp W."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <begin position="15"/>
            <end position="42"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="110" mass="12848" checksum="79ABECDA247B8E28" modified="2022-05-25" version="1">MGLEVDDDDVEELVEEHSKELSTEELLELHKEENETLKRSLTSEESGEEEDKEESRIIPAKDLKDAFFCWNKLSKLAEDYHPDVGSVQKAISVFNDNVMNYFWKIARRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR58</accession>
    <name>A0A8J5MR58_HOMAM</name>
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                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="376" mass="42908" checksum="6838087DDF261DFC" modified="2022-05-25" version="1">MAGIDSQHIKDLIAKGNRFEAMNIFIQSKFGKPDNPETGIKIKREVGEPILKSKKSKGGDKASQSKDNSESETDGSGSDSDSCGSSHASSSAPRSEALVPEVELKEDENLDVDIETVDPLSEALLPRPHLLDQPGPAHMGHPQQNMQAISHIPRIQREKEPVPGDLHKKTHQKFFRDQGRPYISRATGKEIRGRAMGPPCNCKKRCWSKIELGADEIFSAFWDMGNFDEQNVYLYGNISIKPVSRHYVKGSNRRTYTFTYWCKVRGKHVEVCKEMFMGVHGLQNSRGRIGNLMKQMKDGNLLPKPDQRGKHSNRPNKYTEQSLQAARRHIEMYINRNMTLKKMYRDFYMPWCDENKIGAVSEDKYRRIYSEEYKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MS34</accession>
    <name>A0A8J5MS34_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MS34"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="200" mass="21297" checksum="0676E0FF6CD6577C" modified="2022-05-25" version="1" fragment="single">TTRQILHVRTRDKVSFAEARSTALKSVSSHGDSYAQVLSRHKAQQTTSLVVAEVNRNEAGTSATPHFSSTRCAGTIKISAKWYQVSSESLEVDDPPAKVLMVTAKEMSAQTGTSSPEMLTGPLPDTSGGETPVKIKLAAQGVAYMDRPSGEPSPGVKSGYLAFYSLQNPEQTHHEGTAILVSDKYSIPNTCSPLSVTSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSN0</accession>
    <name>A0A8J5MSN0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027337">
        <property type="protein sequence ID" value="KAG7162710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSN0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="214" mass="22286" checksum="13D4B9972649AC8B" modified="2022-05-25" version="1">MESSAFPPRTSDSASLSAKLEAPPSPPVYPPRNMEMPYGQRPLPEHPMGYSNYSPGSFPPSSGPYGPPPVSFASLPPSFTPSSLAPSLSSTPGFPPSGATGSPPLEAFVQLLLAMNVEDQLKVTIPSLLFNETPYVTVKDPQSTGRRPLEEGRSATLVGRDVRVKALAAGTAAVGHPSDGGSGPSGGQEDRYSQTTPLLAEFCCFGVKTDPGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MT01</accession>
    <name>A0A8J5MT01_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative olfactory ionotropic receptor IR4-like 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Ir4-L13</name>
        <name evidence="1" type="ORF">Hamer_G007963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MT01"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="143" mass="15899" checksum="1D94FF25A0565043" modified="2022-05-25" version="1" fragment="single">MATVTYSDYSVFLLMDGSTSPSTVYSLRELSSQTTIVVISDESAFFAAFAEWSFKSRLLVWSVRLLAVTRLSLPELHHLHGTFSKMNAMLAIVNDISANIRCSIYVHLPYSPPGTQALKVASWTPLRGLTLTTHLPLFPDKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTN5</accession>
    <name>A0A8J5MTN5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7162997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTN5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="130" mass="14517" checksum="E03F12EB9BCCFBF6" modified="2022-05-25" version="1">MMAVGKVNKESPKPNQTNSLVELQQIEAELSDSDQALPANQEEEEEMVNDLTPSTSPPRNREVLSVYRGERQSVAATLVDTVEAARSVPAPGFSDVQVEDLQEIVGQHKQQPTIEEMLEDDEKQEEQQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTQ5</accession>
    <name>A0A8J5MTQ5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTQ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="79" mass="8905" checksum="62F5E7CC672BB845" modified="2022-05-25" version="1">MSSRGSNTPKRKYVTLSVNQKLELIRKLETGVKMFDGDYAPSWSECEKVTFYNNGGGDDDDDDDDDDDDDDDDGDDDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUP2</accession>
    <name>A0A8J5MUP2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phenoloxidase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PPO1-L</name>
        <name evidence="6" type="ORF">Hamer_G005124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUP2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF4">
        <property type="entry name" value="PHENOLOXIDASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemocyanin N-terminal" evidence="4">
        <location>
            <begin position="62"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin middle" evidence="3">
        <location>
            <begin position="137"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin C-terminal" evidence="5">
        <location>
            <begin position="352"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7164723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="618" mass="70400" checksum="C6C5B0F4337E2D44" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVI7</accession>
    <name>A0A8J5MVI7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glutamate receptor 1-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Gria1-L3</name>
        <name evidence="10" type="ORF">Hamer_G004671</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7164947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVI7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF39">
        <property type="entry name" value="IONOTROPIC RECEPTOR 56A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="9">
        <location>
            <begin position="117"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7164947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="285" mass="32272" checksum="DB0777153D97FC97" modified="2022-05-25" version="1">MGFFGASIDVTALPYKPYWGVEADQSYVGSDAMMLKSIGHSLNFTFHVLPTANWAEVTRLVEERISFIAPVSHTLLPQRSLLYDYTYAYEHVFMHFFMTKPLLSSNWQSLYDPLADEVWTSILVVLLLMPLLLIAITRPEHGEEFDKKLKQGDAAHIVVGTFLDQSVNKRHIVNSASRVLVAAWLVFSFIVGTAYRSNLTAALTLPKYPSRPETLEQLVRVADKVTMAPYGEEFRQFFKQSESDVFHALSEIMHIVPSTAHGLQWAAEKKYIVQNVLCIVVKDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVJ8</accession>
    <name>A0A8J5MVJ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Gastrula zinc finger protein XlCGF26.1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Zg26-L1</name>
        <name evidence="11" type="ORF">Hamer_G007277</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVJ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001485">
        <property type="entry name" value="Krueppel-related zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000384">
        <property type="entry name" value="Zinc finger protein 550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF34">
        <property type="entry name" value="PR_SET DOMAIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7165443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="298" mass="32892" checksum="BB02994540822361" modified="2022-05-25" version="1">MNGVMVQPKDILGLSSFQDNMGRVPGGSLSHRMSAFTSNITEGGGWGSAVKCNYGINWGDTRVNTENVVKDDRPFPCPYCPLSFKRRYTLQEHVRIHIGARPYACRSCGKTFTQRSSLLKHVRVRVCQKHSGGDSLLGTRRNLKRDPDLCPPAILGLGSHLTPNLLRVDTTTVAAGSMYHALVDAAGSCITGGRTDVKSRVSVNPLGASVRSDYKSSSLNPLAAAAGLDDSVERPYPCHFCDARFKKKQHLQNHERIHTGEKYVCTLCGQAFSRMHILKHHLERKHTDPSNTVYHLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW35</accession>
    <name>A0A8J5MW35_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate receptor-like 69</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Glrk-L69</name>
        <name evidence="16" type="ORF">Hamer_G028280</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023417">
        <property type="protein sequence ID" value="KAG7165816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW35"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="18"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7165816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="409" mass="46550" checksum="62CD08568AE10D56" modified="2022-05-25" version="1">MPYPVIIDYEKGKEPGTPLTPKDSLDVHMLDIIAKQLNFTYELREPLDKKWGTRADDGNWTGIVGTLQHQQADFSLDLTLTESRSRVMDYSRVYYQDPIVIVSPKPTPLPRHLALTRPFEGELWLVVAVCTLVLGIILWLLQKIWSWASGDRGASLVSTLFDSWGMLLMKPVTEIPTNTNGRVLVGWWLLTCVIITTAYRSSFIAHLSVQSKYPPINNFQDLLNRDGWSWGSKTIQGSVFIYFNQSSDPDIQKIFRKMEIYSMEDGLKRVLTGGFSLIVVKIHVRVHAGEIFFDQYGNSPYQLARTEYPIFGGNVWGFRQGAPFTSKISKMKGRLIEAGLLNLWLDDIIKTQTELKETEREREKLTLDTEESSTQVVLGLDHLQGGFYLLLLGCYLAFLAFIAEMIVHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWF3</accession>
    <name>A0A8J5MWF3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024092">
        <property type="protein sequence ID" value="KAG7165559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWF3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="120" mass="12680" checksum="BE261F384588FF76" modified="2022-05-25" version="1" fragment="single">MGFAASLHSLTQVFCGNAGNADGEVQAREVTASTGSSRHRLSLRPLHALTGQFYRSQSSQMAVVQHTMMAQLDTGRVGGTGVGGGGGGGRASKVSHKPWRSQFNQFKIEPLLIRNAPSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWL6</accession>
    <name>A0A8J5MWL6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pro-resilin-like 159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G026956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022469">
        <property type="protein sequence ID" value="KAG7166568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWL6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035319527" evidence="4">
        <location>
            <begin position="16"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7166568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="540" mass="58103" checksum="133D55C134BF30D2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MX75</accession>
    <name>A0A8J5MX75_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G010244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MX75"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7167840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="239" mass="26195" checksum="48F196D5853C89A7" modified="2022-05-25" version="1">MGYIRNGCHHHTHTRTSLTLLLFPPPVCVSLYFTSFTPPTRSIMRLCVMFSCCLIVLLAFVYFSDAASNDKPRYSETEEVRRPKTPRNSKKSEGAKTKKRPGSPKSDQARVEKTYAKRTTCPTKCTKKGGVCQSQSSLCNGNLKKGKSWCGGKTCGCCLAKGACTAKNTCKKEGGVCQPASSECDGELKKDRKYCKGKSCGCCVPKKGEVMPAGHLISQDLNFISSLFCFSILTYDFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY27</accession>
    <name>A0A8J5MY27_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019693">
        <property type="protein sequence ID" value="KAG7168650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY27"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="80" mass="9338" checksum="A8644BD94B74C8F5" modified="2022-05-25" version="1" fragment="single">MVCAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEVIQREEELCQDVYHFFDSSSDEQEATSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZ73</accession>
    <name>A0A8J5MZ73_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="18">UDP-glucose:glycoprotein glucosyltransferase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Uggt1-L</name>
        <name evidence="18" type="ORF">Hamer_G021996</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61304"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:59080"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017059">
        <property type="protein sequence ID" value="KAG7169373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000004">
        <property type="entry name" value="UDP-glucose glycoprotein glucosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035239443" evidence="13">
        <location>
            <begin position="25"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="14">
        <location>
            <begin position="42"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="15">
        <location>
            <begin position="327"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="16">
        <location>
            <begin position="614"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="17">
        <location>
            <begin position="1128"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1399"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1399"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1410"/>
            <end position="1419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7169373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1419" mass="160884" checksum="905B9668CFA58212" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZA7</accession>
    <name>A0A8J5MZA7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Larval cuticle protein LCP-17-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LCP17-L1</name>
        <name evidence="3" type="ORF">Hamer_G011615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZA7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7168936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="176" mass="19283" checksum="A699BBD6106963FA" modified="2022-05-25" version="1">MWTGMDLSCLLLWFSQDSPLHLVYIYWAAANGRITSRPSSPATVSTLSLPAANMRFIGVVVVAASLVLLTDPATADPSSPYRPSPYRAPVIPILKDDRTQDRFGGYSFSYNTGNGIYRNEEGKQSYGQNSEGGWSYTSPEGVPVRITFVANQGGYQPVGDVIPVPPPLPYSRTQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0E4</accession>
    <name>A0A8J5N0E4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Longitudinals lacking protein-like 35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lola-L35</name>
        <name evidence="4" type="ORF">Hamer_G019726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014926">
        <property type="protein sequence ID" value="KAG7169912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0E4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF98">
        <property type="entry name" value="PRE-LOLA-G, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7169912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="280" mass="30179" checksum="CEAF8241754132E8" modified="2022-05-25" version="1">MGSEQHYSLRWNDYTVKIVTAFQSLRDEEDFVDVTVACDGHSYSAHKMVLSACSPYFRALLRANPCQHPIVILKDVGHVELERLLEFMYNGEVSIAQDQLAAFLKTAENLKIRGLAGSSDDMDQAGLHRPDVSYSYSSGSAIGGMTSGRSSPSAGYAPSQGSKDEEIVGDGSGGYLTRPESPPSKRRKRTSAPAAGHADSNTASHTTECVVGDNPVELDTGGVPISGGEDDIRLDRRELKSEPGDAMTDVYSESSEMSTDPQSHTGEGMDQRQPVLYPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0V5</accession>
    <name>A0A8J5N0V5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AT-rich interactive domain-containing protein 4B-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Arid4b-L1</name>
        <name evidence="1" type="ORF">Hamer_G013714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012455">
        <property type="protein sequence ID" value="KAG7171263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0V5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="81" mass="8819" checksum="5214584D0D205519" modified="2022-05-25" version="1">MWLPQPEDPPFLTVGTEVSAKYKGAFCEAKVHKVVKVVKVKLALQIVKASSISWYSGGLICWMVLDIDGCGYADESCQPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N165</accession>
    <name>A0A8J5N165_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat and SAM domain-containing protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ANKS6-L</name>
        <name evidence="6" type="ORF">Hamer_G013447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N165"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="274"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="621"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="508"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7170631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="685" mass="73068" checksum="C8AE4EF4BE4E25F7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N278</accession>
    <name>A0A8J5N278_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N278"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="84" mass="9331" checksum="FDF09A38AEBCE5F5" modified="2022-05-25" version="1" fragment="single">MIRCDYHYLKELVGLYTLASLKPFPPDESSQVKSSHVASCHVKSQMGFGSSSCVNDAESTIKQLIQRENIRPSSSKSVWVLSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4V0</accession>
    <name>A0A8J5N4V0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Misato 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">msto1-L</name>
        <name evidence="6" type="ORF">Hamer_G018708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the misato family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009960">
        <property type="protein sequence ID" value="KAG7173421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4V0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06060">
        <property type="entry name" value="misato"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
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        <location>
            <begin position="134"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7173421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="536" mass="59250" checksum="63D06D8129AAE718" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N656</accession>
    <name>A0A8J5N656_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Titin-like 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ttn-L24</name>
        <name evidence="2" type="ORF">Hamer_G027684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008370">
        <property type="protein sequence ID" value="KAG7173968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N656"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="803" mass="87146" checksum="26921A7F45CB8FA7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N699</accession>
    <name>A0A8J5N699_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type mannose receptor 2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Cman2-L2</name>
        <name evidence="4" type="ORF">Hamer_G003336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N699"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="138"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7174396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="272" mass="30906" checksum="8EA38071D518F68F" modified="2022-05-25" version="1">MTGEKNEDEEEEGAWVERRKIGRVQGEYIFIPVEVWLDSEMTTTKPWLLLMTLPLLFYVGRGTTTSCSPREIECATGEQCISTRLVCKGGTDCPDSSDENPEICEKLLLGKLEDVVEAPKDPKPQLKLADCPSLYTKLGDQCVSFLPTAKVPWPEARQFCKSIYSDLWTFSDPTSFLAMYQFIRNNNVTFDLWIGGYYDQQQSAWAFIQPGDSNHDAPIRDDLPNNAMPLGFPYWAPRCAIVNHNLSFYLSDEECQNKHTPLCLLVSDPRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6E7</accession>
    <name>A0A8J5N6E7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">JNK-interacting protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">syd-L</name>
        <name evidence="4" type="ORF">Hamer_G022818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008466">
        <property type="protein sequence ID" value="KAG7173949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6E7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030159">
        <property type="term" value="F:signaling receptor complex adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1000">
        <property type="entry name" value="arf6 gtpase in complex with a specific effector, jip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039911">
        <property type="entry name" value="JIP3/JIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032486">
        <property type="entry name" value="JIP_LZII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886:SF4">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886">
        <property type="entry name" value="JNK/SAPK-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16471">
        <property type="entry name" value="JIP_LZII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JNK-interacting protein leucine zipper II" evidence="3">
        <location>
            <begin position="354"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="776"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="418"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7173949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="809" mass="90730" checksum="9E4459DF230B250F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6I5</accession>
    <name>A0A8J5N6I5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myosin heavy chain, muscle-like 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Mhc-L11</name>
        <name evidence="12" type="ORF">Hamer_G003144</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6I5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003012">
        <property type="term" value="P:muscle system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="11">
        <location>
            <begin position="35"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="87"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="180"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7174236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="220" mass="24978" checksum="BAE2B0DA9D2F066B" modified="2022-05-25" version="1">MPGHVKKSEGPDPDPAEFLFISLEMKLKDQTKPYDAKKSCWVPDPQEGFLEGMIQGTKGDLVTVMANGETKNWKKDQVGQVNPPKYEKCEDMSNLTYLNDASVLYNLKTRYVNRLIYTYSGLFCIAINPYKRYPIYTNRTVKIYQGKRRNEVPPHLFAIADGAYMNMLQCNENQSMLITGESGAGKTENTKKVLSYFACVGATTKKPGDEQKKVKRSEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7F6</accession>
    <name>A0A8J5N7F6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B-cell CLL/lymphoma 7 protein family member B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BCL7B-L</name>
        <name evidence="3" type="ORF">Hamer_G015719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCL7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007499">
        <property type="protein sequence ID" value="KAG7174595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7F6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006804">
        <property type="entry name" value="BCL7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12767">
        <property type="entry name" value="BCL7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12767:SF9">
        <property type="entry name" value="BCL7-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04714">
        <property type="entry name" value="BCL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7174595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="105" mass="12009" checksum="7DC6387D6B583C83" modified="2022-05-25" version="1" fragment="single">SLFHCPYFREKKWITIHDTTMKIYKWVPIVTDERKKKSGSSANKENRMCSRDSSMSAFQMGGDDSNTAMSMMSDSQDATDFSSTQFNISEDSNSEPPFKKKLMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N855</accession>
    <name>A0A8J5N855_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Gosr1-L</name>
        <name evidence="12" type="ORF">Hamer_G003371</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GOSR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N855"/>
    <dbReference type="OrthoDB" id="422156at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7174428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="236" mass="26978" checksum="3356A96AD8074AA8" modified="2022-05-25" version="1">MSTTAESEVKMSFEDLRKRARQLESEIDVKLVSFSKIAASYGSNSAANANSETVALLSGDQMYETISVELEQLLASLTDINERMNSCPHGSSVATIHTLQRHRDILQDYTHEFQRTNNAIKSRREREQLLGSGRNNSKSLSGLSRRDLYLKESEHLANTEGMVDEQITIAVETRDHLKSQREAFKMIQTKVNDLSNRFPLLNTLMTKINIRKRRDSLILGTIIGLCLTFMLWWMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9R7</accession>
    <name>A0A8J5N9R7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G024298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004850">
        <property type="protein sequence ID" value="KAG7175672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9R7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="192" mass="21898" checksum="C996888ACBABDD50" modified="2022-05-25" version="1">MSVIRIHRYHLPGGTPRHASRIMGVLVIVATTSIMWVQHRLPLPPIIAHHQDHPEMFISDQIQKKPEDNFSKTQEELLALTPSRGYTQPGCNCIRFGFDVAALRKTSQSVLEKPWLYPAWFKTKYSFQGESTCSHFSTQRGRQRVVSFSYYNPNSTTDIGNLVQQQVVGGLWRLAVMGDPTVEVFLSRDLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NEL7</accession>
    <name>A0A8J5NEL7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NEL7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="125" mass="14476" checksum="5874155207BBCCBE" modified="2022-05-25" version="1">MGLEVDDDDVEELVEEHSKELSTEELLELHKEENETLKQSLTSEESGEDEDKEESRIIPAKDLKDVFFCWSKLSKLAEDYHPDVGSVEKAISVFNDNVMSYFWKCSRLLRYLALIDVTKAVFIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T4K7</accession>
    <name>A0A8J5T4K7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T4K7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="98" mass="10857" checksum="F0AD60BEBDA0F2C1" modified="2022-05-25" version="1">MRLEKEDGLYTEGGLVSLLQPTVGQVPLLIFTYLGFSLFVSGFILTVLAYAPTDSYLMVMIQGMAVMSFLGPIILVIGTIMLLVAIFYCLFSKDDEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T7C4</accession>
    <name>A0A8J5T7C4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Hamer_G008658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T7C4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Activin types I and II receptor" evidence="6">
        <location>
            <begin position="154"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7173131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="336" mass="37182" checksum="73595E8EE4B5E106" modified="2022-05-25" version="1">MAALRVSTWYSSSVACTVHSLGMTGAAQCPCSHTQLHPDWEVSTHRRPLSISRFKTSHKTLGGYVIPKENSTTPWACDATPKSHGASSLHNYTTPENRGVTPRDDRTTRQPPLLLFLLLLLTRPLFMVGVRDGLYISLSTHRVPSYNRFRERLITCECSKAECKEDGYTCTATGCYLQLLDRRDGSQPITSGCLTEKGASLLCMNQPPAVRFVPWPYLVCCNTNFCNRDVALTNDLVTRSDEVDSLRRLGVSSIEEFREKYDKDTLESDSDDLNTVYLAVIGAAVVLMIAISAAGFCVLAKYRSKHSRPPHVSLDNGMEKLKSSPVEPSAPPLLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5THP0</accession>
    <name>A0A8J5THP0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G026951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011255">
        <property type="protein sequence ID" value="KAG7172412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5THP0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7172412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="596" mass="65843" checksum="EFE6CFDA00F147D2" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIB4</accession>
    <name>A0A8J5TIB4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIB4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="61" mass="6620" checksum="DC04DDB594DAD79D" modified="2022-05-25" version="1">MNIGNPGTFEIEMNKMLERNSIPTMSFPDNPASGSVLQASRLTNPVEPQETDKAEKKGAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKB9</accession>
    <name>A0A8J5TKB9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKB9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="162" mass="19376" checksum="584D399B58550760" modified="2022-05-25" version="1">MAGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDTYRQHLDDIEEIRTFSQVDVMRKRRFNVRRDPCQFYNEKEFIQRYRASKDSTRTAYSQRQDFVTVCRPDSAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKQ7</accession>
    <name>A0A8J5TKQ7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Rpn7-L</name>
        <name evidence="6" type="ORF">Hamer_G009173</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKQ7"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="193"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7176370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="389" mass="45517" checksum="31E3810564F669AF" modified="2022-05-25" version="1">MPSENLEEQGLEKNPDLHLSQLKFKLMLNDFKNDSKMKEELMQAIEKDNMAPFYEECCHDLGWQLDNAMLERMKKVNETELNTMNEAIEEAEKSMGETEIREANLKKAEYLSRIGDKDEAVKAFAKTYDKTVSLGQRLDLVFHNIRLGLFYLDHSLITRNLEKAKSLIEEGGDWDRRNRLKVYEGVYSMAVRDFKKAANLFLDTISTFTSYELMDYTRFVGYTVLVCMIALPRNDLRTKVVKGSEIQEVLHSAEDLKSYLLSLYECQYHTFFQKLSWVEGELRHDRLLAPHYRYYVREMRILAYSQLLESYRSLTLHYMATAFGVSNEFIDRELSRYIAAGRLHCKIDKVGGIVETNRPDSKNWQYQAVIKQGDILLNRVQKLSRVINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TQA3</accession>
    <name>A0A8J5TQA3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">THAP domain-containing protein 4-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Thap4-L1</name>
        <name evidence="8" type="ORF">Hamer_G015419</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TQA3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7176613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="580" mass="66494" checksum="27F7F5D4E7A03EF0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TVQ8</accession>
    <name>A0A8J5TVQ8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PGAP3-L</name>
        <name evidence="9" type="ORF">Hamer_G021898</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000907">
        <property type="protein sequence ID" value="KAG7177948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TVQ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 8" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035341188" description="Post-GPI attachment to proteins factor 3" evidence="8">
        <location>
            <begin position="19"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7177948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="338" mass="38945" checksum="EC494231A43664F7" modified="2022-05-25" version="1" fragment="single">MWLLWSLGTLLIVGVAQASKGDNSNEYTGCYHVCHFNNCTSRLGIAAYESSQSLSEKILQWTCDDECQYYCMWRTTQIFLDRGMDIPQFFGKWPFARIWGMQEPAAVLFSVLNLMAHLINLRRFRQSVPPNAPMYKIWHLHAGICINAWVWSVVFHARDTPWTERLDYFFAFSMVLFSLFGLVIRLLGPQLKVYKEAAAVVGVLFFGYHVWYLTKGRFDYGYNMTVNVVVGVLNGSGWLAWAVPRLKSRPYIQWCVFTVVGAMASMLLELGDFPPLFWAVDAHALWHLATSPLPFMWYREKTRVKLRGNGTVSYEEYYVSCASLTRLIKWLSVLDAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J3N8</accession>
    <name>A0A8J5J3N8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pogo transposable element-like 89</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Pogo-L89</name>
        <name evidence="3" type="ORF">Hamer_G009323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J3N8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018586">
        <property type="entry name" value="Brinker_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09607">
        <property type="entry name" value="BrkDBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="TrpR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brinker DNA-binding" evidence="2">
        <location>
            <begin position="3"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7153657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="117" mass="13416" checksum="F705DA74BC905DF0" modified="2022-05-25" version="1">MKYDASFKLKVVRFAKASNNSAAAREFGVNEKQDREWKKAEEKLIDVPRTKCAPRRGKQQWPELKEKLFEWVNENREIGYVITGNAVCIYAVKPAKSNSDTGNRSRVGGLGFTRRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JD99</accession>
    <name>A0A8J5JD99_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease 8-like 1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Neil1-L1</name>
        <name evidence="2" type="ORF">Hamer_G024701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041489">
        <property type="protein sequence ID" value="KAG7155491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JD99"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF27">
        <property type="entry name" value="ENDONUCLEASE 8-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="1">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="197" mass="23031" checksum="2CB0D67993CC343D" modified="2022-05-25" version="1" fragment="single">MPEGPELFLASLFINTVSQNRRYGGRVIKSEISTKNPDVEWEAEVYRVQAVSRGKELKITLCEGQEEHKGEKTLDIVFRFGMSGSFKFTTVQEIPKHSHLRFFTLNEDTPMVLSFVDYRRFGRWEVKDTWGLDRGPDPMWEYQSFRENVMTHLNLAAFNKPICEAMLNQKYFNGIGNYLRAEILYRQVSPERGRDCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JE49</accession>
    <name>A0A8J5JE49_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-cytochrome b5 reductase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Cyb5rl-L</name>
        <name evidence="8" type="ORF">Hamer_G006629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JE49"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="70"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7156642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="309" mass="35676" checksum="B76AD38B4C04E503" modified="2022-05-25" version="1">METRELVDIEELLPPKPRAPKPSDCCGSGCCPCVHDIYEQDLKTWKKECELIRNGGREEEPHAISAVQPEKWKEFEIIKINDINNNTYLYTFKLNDDEHLGLNIGHHLIVKQRINGKAVTRQYTPVSAINKRGSFEVLIKIYPTGKITPIIKEWKVGDLIPWRGPFGSFTYKINSYKRILMLAAGTGIAPMYQIIKSILENEDDETFVRLYYASKSFSNILLRDELSNYCQFWNFTMCHYLSGEVDMGQKRYREEAMDRRMAKDDIRQELVKGQVDSTLVLVCGTKSFDKDMVNAAKDANIPNQNIFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFJ3</accession>
    <name>A0A8J5JFJ3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polynucleotide kinase 3 phosphatase and FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G014995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFJ3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="288" mass="32228" checksum="3F8E4163974581E0" modified="2022-05-25" version="1">MALELLADYTSYTVIVRQLGPNVTGVNNKGLLFGNTALLKHSDILELLENIVAGVQRKISSIIERLGVPIQAFVSTGKESTETCLRHANGGVDIDMDESLYVGDAAGRPAEGSRKKKDFSFSDRLFALNIGIQFFTPEEHFLGCQTQKFNMPEFDPRACDDSLPLFDPPSTRVPKHKLEVIILVGYPGSGKSFLSLTHFAGLGYVQANRDTVGNWQKCVAIMEKSLQFREFSGTDHSKVSDMIYNMYKSKYAEPSLSEGFDDIVKVNFVPKFRTSDEEKLYRMFLLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGA9</accession>
    <name>A0A8J5JGA9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G028999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039640">
        <property type="protein sequence ID" value="KAG7156179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGA9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46114">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46114:SF1">
        <property type="entry name" value="ZAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="73" mass="8409" checksum="0BFC4510D7CAD920" modified="2022-05-25" version="1">MGISYNISEWRLFIDSSKRSLEAVLLFNGNQVASVPVGHSVQMDENYNNMEYLLTALKYKDHNWKICGDLKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ73</accession>
    <name>A0A8J5JJ73_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G010010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJ73"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="332" mass="35581" checksum="093BE9D654BD1F4C" modified="2022-05-25" version="1" fragment="single">NDELRLLESQIKLKEIGIRQAEAEAIAKRCEIRQAVAEAKAKEADSENLRLCMKLGGAGCVRYLIGRPNLLHILVVTVESQVIRQVCWTRLQLNTGKPAMIVTEETNTSPVGVMADLSKADSMPIGLIFTKGEVRESAVSVLASRDFDPSQENFAKNPDVVSKLSSKSVVAARKTDKYVVLGSLWGQGVAPLVLVRVKSSCFSGIANIACVHELPVAGGDLILGNDLAGGQMGNVTPPPVLREKPESTAELQQLEDDMPGVSPLCDHNVTSVVDDSLSSKGLFANPIASQDISSAVIAVTGRVALIAAEEQDDSLRLLFHSANDSGYTTRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLV9</accession>
    <name>A0A8J5JLV9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Sialin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">H(+)/nitrate cotransporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">H(+)/sialic acid cotransporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Vesicular excitatory amino acid transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">Pht-L6</name>
        <name evidence="28" type="ORF">Hamer_G017365</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitrate(out) + H(+)(out) = 2 nitrate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71539"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:71540"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>D-glucuronate(out) + H(+)(out) = D-glucuronate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72591"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:72592"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-aspartate(out) = L-aspartate(in)</text>
            <dbReference type="Rhea" id="RHEA:66332"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66333"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-glutamate(out) = L-glutamate(in)</text>
            <dbReference type="Rhea" id="RHEA:66336"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:66337"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-acetyl-L-aspartyl-L-glutamate(out) = N-acetyl-L-aspartyl-L-glutamate(in)</text>
            <dbReference type="Rhea" id="RHEA:72599"/>
            <dbReference type="ChEBI" id="CHEBI:76931"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:72600"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N-acetylneuraminate(in) + H(+)(in) = N-acetylneuraminate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28987"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35418"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:28989"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7159931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLV9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000067">
        <property type="entry name" value="sialin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="7 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="27">
        <location>
            <begin position="44"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00056891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00069713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00080244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00081195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00081925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAG7159931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="436" mass="46859" checksum="464E8C0F6401DA0F" modified="2022-05-25" version="1">MPRDSLQQRPGTQDVLRRMVEDDHHLIETVPQTAPEGCFGARHILAFLGFLGFANVYAMRVNLSVAIVAMVNNTAIPHTNKNESDVCPASADNTTHPVKDGEFPWGETEQGLILGAFFYGYVLTNMLGGRLGELVGGKIVFGIGVLVTSIMTIFTPVVARASTPLFIALRVIEGLGEGVTFPAMNSMMAKWVPPLERSKMSSLVYAGAQFGTVISLPISGLLCQSSFLGGWPAVFYVFGVCGLLWFIVWMLLVHNTPESHPRISLDEKIYIQTTLNQSPSNTKSGFISALPYLVMWLFSIAAGQVADHLRARGILSTTATRKIFNSIGIYGPMICLVLVGYAGCHKDAAIALLCGAVGLNGATLSGYINSHLDIAPNFAGTLMGITNTAATIPGFLAPQLVGYLITGKMLQECGRQEALGSMALLQPRKTFSKAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLW3</accession>
    <name>A0A8J5JLW3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035099">
        <property type="protein sequence ID" value="KAG7158426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLW3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="205" mass="25317" checksum="9F61B8A05D8B7580" modified="2022-05-25" version="1" fragment="single">MKKEDKLEKKKKFKEKKEESEEREFKKKEEKLEKRRKEKEKDEKEVDEKKKEVKKEIDEKKKEVNEKEDEVDEKKEFEVDEKKDEEDELEVDDEKKDEEEELEVNEEKEEEELEVDEKEEELEVDEKEEELEVDDEKEEELEKKDIIEKEEEGKQEKDIKIIEKEEEEKKKEFIIKDEEGKEFKDIKIIEKGEEEKKKEEGKDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMA9</accession>
    <name>A0A8J5JMA9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bromodomain adjacent to zinc finger domain protein 1A-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BAZ1A-L2</name>
        <name evidence="8" type="ORF">Hamer_G027418</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040705">
        <property type="protein sequence ID" value="KAG7155739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMA9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031445">
        <property type="term" value="P:regulation of heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047171">
        <property type="entry name" value="BAZ1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510:SF1">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="6">
        <location>
            <begin position="408"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="662"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="683"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="699"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7155739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="727" mass="85428" checksum="7A4C165A84F45B12" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMC1</accession>
    <name>A0A8J5JMC1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Potassium channel regulatory protein unc-93-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">unc-93-L</name>
        <name evidence="3" type="ORF">Hamer_G022160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040691">
        <property type="protein sequence ID" value="KAG7155754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMC1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7155754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="9557" checksum="32BFAEFC40C9D7E7" modified="2022-05-25" version="1">MVQDGGPGMDNPAFTSPEDAHHETRQKSEENVSSGSVETSRRQLTEEERKEKFAIMKNIIIISVAFTFLFTSYNSMSNLQSSINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNI9</accession>
    <name>A0A8J5JNI9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030392">
        <property type="protein sequence ID" value="KAG7161026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNI9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="434" mass="50175" checksum="DFC93969557E8F1A" modified="2022-05-25" version="1">MEESESQSGENAKGTVRPTSSTTRSATEIYLVGQPASSIRGSKLPTMRQVLKFFFHTVNESGDRQETFKETVRNVLTFWNLARIKTISERGCREKLTRLWEHWRSLQKSRDRAAKDKVENFKSQLDLLWDIGAPDAVEDIEKNRLLTPADKQQDIAFYQDQQWAREDYREAAELTLLVLGVNPPRGTHFLRPGACHHARWMVKIIYYLKIYMFSHQLELSSDLCVKLQRMAIFVSLLYTPAWLKSPVAEDAPVNDLQLHHELLRYRAVDCEVADAALAVASRHLWYLRPQTVVLSLCSEKLSAAEKKEMATKLSCLEETNDYANDNLVIQQTTRLSDLIDERSWMIFKEHHVCGTAWLMSPVEDWEKNEEFMKLKDFSRSLKVTNDVAERGIKLMLDFIGSVTKDEQQLQDVMQLVEKHRKQMSGFSKSALMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNV2</accession>
    <name>A0A8J5JNV2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Xylose isomerase</fullName>
            <ecNumber evidence="2 8">5.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">XylA-L1</name>
        <name evidence="9" type="ORF">Hamer_G016275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>alpha-D-xylose = alpha-D-xylulofuranose</text>
            <dbReference type="Rhea" id="RHEA:22816"/>
            <dbReference type="ChEBI" id="CHEBI:28518"/>
            <dbReference type="ChEBI" id="CHEBI:188998"/>
            <dbReference type="EC" id="5.3.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the xylose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.5" evidence="2 8"/>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNV2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009045">
        <property type="term" value="F:xylose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00455">
        <property type="entry name" value="Xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001998">
        <property type="entry name" value="Xylose_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48408">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48408:SF1">
        <property type="entry name" value="XYLOSE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00688">
        <property type="entry name" value="XYLOSISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51415">
        <property type="entry name" value="XYLOSE_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0859">Xylose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7161221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="985" mass="110300" checksum="900DCCC6BA90B020" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQJ8</accession>
    <name>A0A8J5JQJ8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G005812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQJ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035212140" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33566" checksum="C206A29BBEE5334C" modified="2022-05-25" version="1">MGRLAATISTGGPRPATLLVWLLLMVVLAGSSSGTTDVGYERRDYYRCGHIFKTASVPSLTACAAFCTQESECTGFNIGINRGRQRECQISSDDIECAYDSTYHYYRIPPPLTTTTADPTTTTTLPTYIIELKYFPISSKSCSPGRIITTIVTKPGYPNMTDIIAFVCSKFKSGISCSIDDFVESVTTGDINQPGAVTCPTQSMLMGLEGINNNGGESFIKPDVLQGNCHALSVCYVDESRCLTVYASHELVTWTDGKDKDKVDTTVWDNYLTCPDNYLANQIQRKQTASGWQIFSMNCCLIVSTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQL4</accession>
    <name>A0A8J5JQL4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neuronal migration protein doublecortin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Dcx-L</name>
        <name evidence="3" type="ORF">Hamer_G006441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7159028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004">
        <property type="entry name" value="DOUBLECORTIN DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004:SF23">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Doublecortin" evidence="2">
        <location>
            <begin position="83"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="2">
        <location>
            <begin position="225"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1184"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1576"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1786"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1872"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1932"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="834"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="947"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1007"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1301"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1364"/>
            <end position="1387"/>
        </location>
    </feature>
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        <location>
            <begin position="1390"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1416"/>
            <end position="1431"/>
        </location>
    </feature>
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        <location>
            <begin position="1432"/>
            <end position="1454"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1475"/>
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        </location>
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        <location>
            <begin position="1486"/>
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        <location>
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        </location>
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        <location>
            <begin position="1631"/>
            <end position="1650"/>
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        <location>
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            <begin position="1887"/>
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        <location>
            <begin position="1938"/>
            <end position="1948"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1949"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1973"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2001"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2026"/>
            <end position="2047"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2064" mass="225318" checksum="9DF12BEA387E7AF8" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQW5</accession>
    <name>A0A8J5JQW5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Hamer_G030844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7160721.1"/>
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    </dbReference>
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        <location>
            <begin position="26"/>
            <end position="309"/>
        </location>
    </feature>
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        <location>
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            <end position="45"/>
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        <location>
            <begin position="56"/>
            <end position="86"/>
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        </location>
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            <begin position="190"/>
            <end position="233"/>
        </location>
    </feature>
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        <location>
            <begin position="266"/>
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    </feature>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="309" mass="32598" checksum="3CA919EB5E72940B" modified="2022-05-25" version="1" fragment="single">LSSGALLLSAPTPPAMFASRLQCPNTPSPQYFPTQPTVPNTTQAHSAPIPHPAHSARNTQWPCNSITASPQCPNTTQPTVPQHSSKPTVPTPHTQPTVPEHPPRPQLTSTTAHNAQHHPAHSAPTPHKAVSTNTHPAHSATHQPGARNTTSYSEPTPPSPQCQHHPATVPQHHTSAQYPTSIPSPQWTNSTHTAQAPTPHPAHSAATPYPAYSGPTPHPAQSAPAPNPAHSAPTRQSAHCALHHSPSLSAKHHSKLTVPQHDTQVPPAHLANSAPAPNPAHSAQHHPAHRPDTTQPQCTNTTPGLQCTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5JR70_HOMAM</name>
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    </gene>
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        <name type="common">American lobster</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7159418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="22"/>
            <end position="100"/>
        </location>
    </feature>
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        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="100" mass="11400" checksum="30D2D3E98FC4CFEA" modified="2022-05-25" version="1">MGQEEETCQLLPSVTSVAVLPKRLSVDSNHSPALQRKDKDTDTGEENSKRRKEGVSQSENPVVLEKPKPQQRIIFQDTKHEEEEEGTLFIPSYVNNDHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRP6</accession>
    <name>A0A8J5JRP6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7162931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="271" mass="31012" checksum="800D5CA19CAB5375" modified="2022-05-25" version="1">MSQFNVYGTSKKKACVTMSLCTDWFDKHFLPDTTLNCSTSYQSLYKDFRQQADSLVKLQQIEAELPDSDQALPAPANQEEEMVDDPTPSTSHAPSHNCEVLPVCKFWKKYNIKNTVDRIVETWRKINFATMLQTWKPLFVNFEVSGVEQTEASGERQSVAATLMDTVEAVRSVPALGFSDVQVEDLQEIIGQHQQQTTIKEMLEEDEEQEEKQPTQEDDVKPGEPTTLQLTEMLTTFARFTEQLEEHDTRPHAQNHICPVTEKVIEEYKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRP7</accession>
    <name>A0A8J5JRP7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ETSous factor-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Ehf-L3</name>
        <name evidence="6" type="ORF">Hamer_G016235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRP7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF190">
        <property type="entry name" value="ETS-DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="5">
        <location>
            <begin position="50"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="4">
        <location>
            <begin position="250"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7161186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="345" mass="39236" checksum="8346B9E4106E549A" modified="2022-05-25" version="1">MDPSFDGIESSLTFNDSQPIDNLCNAYLGNMDSYHSTATQGGASGYLDMYACASDYNDDGQHFPAVDVRDWGGNECVQWAESVCEALGVDKASLDLWSTFSSRTGTHLLQLSQQNFSQLLGPQYGPIFHSQLQTLRKRRGNGNSYDLGGASYSPAAISYDFSTSPYDLESWELTNEDFKDLDRYIPEDGWDPLSHDLQSLELQEEFMPIKYDHQETLPTVALAKASPAVKQENNVFEKIPTNTRRRERGPKSWEFLIRLLEDKRSNPSLIRWEDEVNATFRLVQPALIAQMWGARSEKPNLTYFNFARGLRYHYSTGALLPVSERQLVYKFGPKALKHLSERQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRQ2</accession>
    <name>A0A8J5JRQ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032701">
        <property type="protein sequence ID" value="KAG7159703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRQ2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="37" mass="3945" checksum="7C65A726232B8418" modified="2022-05-25" version="1">MRGVCVTVRQGGVRVTIKQAGGCTCYYKAGRGVRVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSM6</accession>
    <name>A0A8J5JSM6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative WXXXramide-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G021666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031456">
        <property type="protein sequence ID" value="KAG7160288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSM6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="626" mass="70151" checksum="2802030D7B214C9A" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JT27</accession>
    <name>A0A8J5JT27_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketohexokinase-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Khk-L2</name>
        <name evidence="2" type="ORF">Hamer_G019951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028706">
        <property type="protein sequence ID" value="KAG7161936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JT27"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="27"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="203" mass="22085" checksum="601BD0E890D87052" modified="2022-05-25" version="1">MKVIFYADMIFKPDYFLQGRNVSNVTKMIERIRQYNRSHQDCGCITISVEIEKAKPELESLIPLPDVLFVSKDYAMFKGYSSMAETVKEIQAQAIPGSLVICPWGEDGASASNSVGKLVHSPAFPPLHVVDTLGAGDTFNAATIFSLSNGHTPKESITFGCRIAGLKVGVTGWEPLRKMAKDGTLCPIVENSSERSGVVIKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTW1</accession>
    <name>A0A8J5JTW1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tRNA selenocysteine 1-associated protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G014294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025553">
        <property type="protein sequence ID" value="KAG7164161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTW1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041085">
        <property type="entry name" value="TSAP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17654">
        <property type="entry name" value="Trnau1ap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA selenocysteine 1-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7164161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="99" mass="11803" checksum="448B6A7B4B7415F7" modified="2022-05-25" version="1">MGGDYSQYYEQYWNNYAAWQNYGTYYDPYASSYGDYHSGIEGGSGDSKDSSKEDFEPVEWNNPIDVNKTNKEYIDRSEELWQAIEKSRWSFWDQVKEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JU57</accession>
    <name>A0A8J5JU57_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025553">
        <property type="protein sequence ID" value="KAG7164145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JU57"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="118" mass="13255" checksum="A20A984D5124056D" modified="2022-05-25" version="1">MSDGQPVPLPVPDKSKRRRSTRPKNRIEIPVIDDGEWSDRDEAEGDEDELEEDEEEDEETPPNKKSKVEEPGPGETQTIKTETPSTIKQPCILIFDSLTGANRASCGNTETISWWSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVD9</accession>
    <name>A0A8J5JVD9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clathrin coat assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SNAP91-L</name>
        <name evidence="2" type="ORF">Hamer_G019922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028706">
        <property type="protein sequence ID" value="KAG7161909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVD9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="289" mass="28502" checksum="4F6970CAF6D5102B" modified="2022-05-25" version="1">MGVLVHLIRVWCFTGGRNGRESKLLCDRCATLFLQAALVGGGTDSDVNPFADFGVSGPPAPSFPPQGGVSSQDTTSTTTTGAADLLGGLDPLTGVGSSGMSSQASTMPPAQSQAFDGFGDILKPEGSVGGGGAGGVPAAPVVGVPTTAPTSQPGKLISSDLDMSLSSLVDNLNIKGPVPQKGQWNSPKTQSKTGGAGWTPVAPVSATGGFRPPMPGQPMAAPGAQPIAGQTGQWSGGMQMGGAFPQQPMQGMGMGSGVMPAGFPAGGAQPGTQPTQPTQPAGFDPFGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVF2</accession>
    <name>A0A8J5JVF2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Golgi apparatus membrane protein TVP23 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Tvp23b-L</name>
        <name evidence="7" type="ORF">Hamer_G004921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TVP23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVF2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF25">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7165137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="179" mass="20425" checksum="02489A18EA0A3467" modified="2022-05-25" version="1">MVTVFHLLFRTAALIMYELSEFITNGFIGSFITIVILLSMDFWTVKNITGRLMVGLRWWNYIDDEGQSHWVFEAHKGRVSQTEVRVFWVALVVFPVIWSILFLIAIGFFKFRWAMVVLIALSLTGSNLYGYVRCKFGKSESISQSFKNMASGLVQKQMISNVANMFTRTPPTTAPSSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVJ9</accession>
    <name>A0A8J5JVJ9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Pyruvate kinase</fullName>
            <ecNumber evidence="5 15">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PyK-L</name>
        <name evidence="18" type="ORF">Hamer_G019656</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20 15">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 15"/>
    <dbReference type="EMBL" id="JAHLQT010024921">
        <property type="protein sequence ID" value="KAG7164817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVJ9"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000025">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000023">
        <property type="entry name" value="Pyruvate kinase PKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="14 18" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="16">
        <location>
            <begin position="34"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="17">
        <location>
            <begin position="402"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7164817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="522" mass="57357" checksum="40E090E2D70CECF6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVK6</accession>
    <name>A0A8J5JVK6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVK6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="244" mass="27472" checksum="9862137A997DC897" modified="2022-05-25" version="1">MLPASDMLPLQDEAVTIEPQYDGVIMLSPEAVLFSDAKPRPDGSKVYHVFERTLGDPPRDEATQSEDFQSRREQLFSQAHENTLHDIQQVLAESGLVNQEWCEASGVGEAADSTSVPTTNAASAYQISDPNFQTPAGQTLTNSNHRTCLTRHQRLTPCRLHQFEMVFPNEQKRRLLKRLRRKGMGYVEFEPENHRINIKTRKSVNTSLSVLRGVDPNARHLGTCRDTLIEETVEPDSSEIMDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVS3</accession>
    <name>A0A8J5JVS3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Cht10-L5</name>
        <name evidence="14" type="ORF">Hamer_G017257</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000007">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000004">
        <property type="entry name" value="Chitinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF359">
        <property type="entry name" value="CHITINASE 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="12">
        <location>
            <begin position="421"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="12">
        <location>
            <begin position="483"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="563"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="12">
        <location>
            <begin position="1054"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="12">
        <location>
            <begin position="1244"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="12">
        <location>
            <begin position="1318"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="344"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="972"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1034"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1103"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="978"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1000"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1112"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1131"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7164862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1408" mass="155747" checksum="8F9F16BEE6791322" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXE5</accession>
    <name>A0A8J5JXE5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neuronal pentraxin-2-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Nptx2-L8</name>
        <name evidence="8" type="ORF">Hamer_G011203</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXE5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051360">
        <property type="entry name" value="Neuronal_Pentraxin_Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277:SF161">
        <property type="entry name" value="LAMININ G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277">
        <property type="entry name" value="PENTRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pentraxin (PTX)" evidence="7">
        <location>
            <begin position="16"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7166367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="256" mass="29139" checksum="F96147699257AC56" modified="2022-05-25" version="1">MLLVVVATVAIENQEEDRVLVLQESGTPSAASYARLVKPFPRLESFTICYRIKLNRFREESTLMSYAVSDDKDNEFRIDHRESGYRVTIQGYWAASQLVTPLRSWAHFCFLYQLNDASWTIYLNGERRAEGSFPGPTTPLEGGGAFVIGQEQDSLGGGFQRDQSFCGEITHLNIWSRTLDHHTLTQVWSCEGGQPGDLLSWSSSLESWQIDGETSWVQRSRHDLCHPTTRIITIFPDRFNLAQADHLCHVSVLYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXF7</accession>
    <name>A0A8J5JXF7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative extensin-2-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXF7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="276" mass="31894" checksum="8648F78E387A4B4B" modified="2022-05-25" version="1">MAGIRYDSTPEHGRILPQNMVGFRPRRWKESAPEDGRILQQNTDFAPEDNRIPPQKTVGISPPNTEEFRRRKRREDFVPKDGKILPQKTVEFRPEYESYRILGKNSTVFWSGIIPYSEAESYRLLAQNPTVFWAESYPILERNPTVFWGKYPGTESYHFLAQNSTIFWGKILPSSGVESYRILRLNPTLFWDGILPYSGAESYPILGRNLPYSGTEPYHLLGRDPTVFWHRFLPSSGAYSYRILGHNPAIFYGIILLSSGAKYYRFLGRNPTVFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYC6</accession>
    <name>A0A8J5JYC6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G028519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023195">
        <property type="protein sequence ID" value="KAG7165871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYC6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="99" mass="11106" checksum="D024B270CEEB7AB8" modified="2022-05-25" version="1">MYNQIEESCLEAAPKLKIPCTYTAIDEAVLQLLDPAFTHGIPAILESEELIDEEEREQTPGPSGARFTAIHSIEESMFRTVQEKEDSLTILLTEDIHTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZ68</accession>
    <name>A0A8J5JZ68_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G013691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022272">
        <property type="protein sequence ID" value="KAG7166662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZ68"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="80" mass="9348" checksum="5F09D0CBCD9EFE51" modified="2022-05-25" version="1">MTYPDAQYSTMTYPDAQYSTMTYPDAQYSTMTYPDAQYSTMTYHDAQYSTMTYPDAQYSTMTFPDDQYSTMTYPDAQYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K072</accession>
    <name>A0A8J5K072_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1276"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1230"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1353"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1384"/>
            <end position="1412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1439" mass="158139" checksum="FF12B957B27A6E0B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1Q7</accession>
    <name>A0A8J5K1Q7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hemocyanin B chain-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HcyB-L4</name>
        <name evidence="4" type="ORF">Hamer_G026650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tyrosinase family. Hemocyanin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021268">
        <property type="protein sequence ID" value="KAG7167701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1Q7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF5">
        <property type="entry name" value="FAT-BODY PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7167701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="640" mass="73240" checksum="99351A6F548F980B" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2J6</accession>
    <name>A0A8J5K2J6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017704">
        <property type="protein sequence ID" value="KAG7169247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2J6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035147954" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10293" checksum="22B90141511CDDCB" modified="2022-05-25" version="1">MVCPLLLPAPLLLLFALKLYLARCNFFIISPSESTCSHKRAGRRGGSERLGLSVAMMPPTATDMGRGSYTGIPHTAHLGPLLLLVATDRWVIFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2V7</accession>
    <name>A0A8J5K2V7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-galactose/UDP-glucose transporter 7-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Utr7-L1</name>
        <name evidence="7" type="ORF">Hamer_G017156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2V7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
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        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="17"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7167246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="247" mass="27014" checksum="837016ECE10014BE" modified="2022-05-25" version="1">MMQGRGPALGAALLYGTISLSMAFLNKAVMSQYGFNYPFFILSCQMILTVTVLEVMRAFGKFGIPKITMAAIKMFAFPSFCYSLHATLSLMALEGMNIPMYGALKRCTPLVNLILAVTYLKKPTPSALVITSVLTITIGCLIAGMSDPTFHGYAYMMGGLSVVLQGLYQTLVEQCGENQLSPLHILHLNSCISVIPFIIITCGKGELSAVFTYQYIGGKLCTVYQIFFGKYNCSCLAYFCKSLHLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K504</accession>
    <name>A0A8J5K504_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ecto-NOX disulfide-thiol exchanger 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ENOX1-L</name>
        <name evidence="6" type="ORF">Hamer_G018426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7167996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K504"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007624">
        <property type="term" value="P:ultradian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12228">
        <property type="entry name" value="RRM_ENOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038876">
        <property type="entry name" value="ENOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056611">
        <property type="entry name" value="ENOX1/2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034140">
        <property type="entry name" value="ENOX_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001:SF4">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23267">
        <property type="entry name" value="ENOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="480"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7167996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="940" mass="105458" checksum="7588D50BFB9F4126" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5G3</accession>
    <name>A0A8J5K5G3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C-Maf-inducing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CMIP-L</name>
        <name evidence="2" type="ORF">Hamer_G021734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021942">
        <property type="protein sequence ID" value="KAG7166918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5G3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="224" mass="25495" checksum="9883BC633A43F0C2" modified="2022-05-25" version="1">MNMTYDHSVISGSLLQFGDVGLQLISEHLHKLQVLNLCETPVTDKGLEALAAIKSLRKLNLNSTSLSVQTFETLKETLPSLLELGRRRRDRDRKQQDSPGEEKNNTRRDFMCLPRFDGKVLSKKNCLVKAKSEEQSTVRRNLLVRARSEDQSTITRNILVRANSEEQNSSTKNVLVRANSEEQTAVTRNLLVRANSEGKRYKISNLLCERQRAVASQETVHYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5Z2</accession>
    <name>A0A8J5K5Z2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative tRNA pseudouridine synthase A-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Pus1-L3</name>
        <name evidence="2" type="ORF">Hamer_G002399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5Z2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="72" mass="7875" checksum="A8F63E5A5A26DB23" modified="2022-05-25" version="1" fragment="single">MASSKENSGDGESLCQGVSMKRASASERTETQVKRINLDASSEVEGGETVRRKRRKYALLLSYSGKGYLGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6K4</accession>
    <name>A0A8J5K6K4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="7">7.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Cytochrome c oxidase polypeptide I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">NADH dehydrogenase subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase chain 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">Cox1-L14</name>
        <name evidence="27" type="ORF">Hamer_G029079</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="7"/>
    <dbReference type="EMBL" id="JAHLQT010019285">
        <property type="protein sequence ID" value="KAG7168731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6K4"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050175">
        <property type="entry name" value="Complex_I_Subunit_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46552">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46552:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="20 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-0520">NAD</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="12 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <keyword evidence="18" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="26">
        <location>
            <begin position="191"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="27">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="27">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00021008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00032715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAG7168731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="237" mass="25674" checksum="A99EA5C1F5718D2F" modified="2022-05-25" version="1" fragment="single">LELNLLSFIPLIITKNNQYSSESALKYFLIQALGSAIIIFSASIILISPSVAPLCLALALLLKLGAAPFHFWFPQSLISSSVALIFHFQQIFHFSQITSNNASPLPNKILIPVLLSLLSLGGLPPFTGIVGTSLRLVIRAELGQPGSLIGDDQIYNVVVTAHAFRNSRKWSRNWVNCLPSALCGNCSRRCFLGGLTGVVLANSSIDIILHDTYYVVAHFHYVLSIGAVFGIFAGIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6M1</accession>
    <name>A0A8J5K6M1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Importin subunit alpha-5-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Kpna1-L2</name>
        <name evidence="9" type="ORF">Hamer_G019034</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021370">
        <property type="protein sequence ID" value="KAG7167638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6M1"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ARM" evidence="4">
        <location>
            <begin position="61"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="4">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="8">
        <location>
            <begin position="594"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="7">
        <location>
            <begin position="741"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7167638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="826" mass="92435" checksum="70B8A97062A892A3" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7R3</accession>
    <name>A0A8J5K7R3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Circumsporozoite-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CS-L7</name>
        <name evidence="2" type="ORF">Hamer_G021580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018031">
        <property type="protein sequence ID" value="KAG7169188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7R3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="177" mass="20011" checksum="0A14FE3887CA9A57" modified="2022-05-25" version="1" fragment="single">MPEMNGYQHHHHHHHHHHHHHIPHPPRYPEGVHNPQPPAQPQQMRDDLFHQINEFNEVMQGVRMRDPGGEYRREALPWMPHQHQQLQQQVQQPAVPALNQQPALPVLNQQPAVPALNQQPAVPVLNQQPAVPALNQQPALPVLNQQPAVPALNQQPAVPALNQQPAVPVLNQQPAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KA56</accession>
    <name>A0A8J5KA56_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Murinoglobulin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Mug1-L</name>
        <name evidence="2" type="ORF">Hamer_G011587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KA56"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF171">
        <property type="entry name" value="PREGNANCY ZONE PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="237" mass="26644" checksum="743C058173918C40" modified="2022-05-25" version="1" fragment="single">VLVWYTRQDGEVVADIRELEVEKCLGSSVNLTWSDAQLEPGQQTTLTLSSEPNSVCSLGVVDRSSELLAVDPDPITLDKLFDFANNFFINIGGNSQINNNKYCKEQQRKEDLKKAAAARLIGDFVPLRRYSSYQTNFVDALKMFDTSGLYIFTDLTVETRPCEAEEAKTLRPQSIISTAGGHVAFSRPQSSFHQDFHETIAEDERFGLRVKGDSSKQADAPRTNFPETWLWDLLILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KFU0</accession>
    <name>A0A8J5KFU0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G013721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012455">
        <property type="protein sequence ID" value="KAG7171269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KFU0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="190" mass="21048" checksum="D9562B8B98F08F9C" modified="2022-05-25" version="1">MSTSTGAGRHTHHHDQIPSVQTSFIKDVHSLVSVIEELGNPFEEESLDLVALHTKEIASPSAAETVRNAKSIGQDQFQTFNREHLMEGTKPTEAPPATSVVLDGAAVLQMLKPAAAMNFEEYAHEVFIPYMSTKLQTVSQLDLVFDWYVADSLKCTARAKRGQGVRKRVVGSATIPRNWQNFLRLDSNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK58</accession>
    <name>A0A8J5MK58_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Unc-13 B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Unc13b-L</name>
        <name evidence="7" type="ORF">Hamer_G018144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044460">
        <property type="protein sequence ID" value="KAG7154414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MK58"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061789">
        <property type="term" value="P:dense core granule priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08395">
        <property type="entry name" value="C2C_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000014">
        <property type="entry name" value="protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF12">
        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MHD1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="6">
        <location>
            <begin position="194"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="503"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7154414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="678" mass="76249" checksum="BE3DBBE79DFE912F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKC6</accession>
    <name>A0A8J5MKC6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc finger MYM-type protein 6-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Zmym6-L3</name>
        <name evidence="1" type="ORF">Hamer_G015065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKC6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF19">
        <property type="entry name" value="LOW QUALITY PROTEIN: ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="413" mass="46580" checksum="95E6A5ADBB68294E" modified="2022-05-25" version="1" fragment="single">MLGAQQGFAACVKELNPNDLIIHCLLHHESLALKKAVWLFWKTCSDFGSEHIHLLCLSVVRNELEIFLNHFVSETKWLLQMAYLTDLLSEINCPNASVQDIGVETTGNAIGTATLNFLHGHAILLERCSSVTTDGAAAMVGVRNGAAAMIKEHATNWHEFTLQNLASEKLSHDKVNSPFDKVMEQLQLCEGMEECDRTLLYYSEVHWLSRGTVLRRLFEFLSETDCPRAAHFHNDLLISKLGYLADMFEKLNVLNVSLQGKDMDPSCGNKCDKFQKWIKKFRKADEDIPTPKPRSGRPRKIQNHTSKVIKRQLDKNPTLTARKLKENNPALLQDVSVRCISDHLLKDLQYRSCCAKFFLLSAKNMRDRIAFSKKYKTGNKSCGVMSQCLWCRLAAGPSVSGVPRSAQMTPLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMW0</accession>
    <name>A0A8J5MMW0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Opn1-L1</name>
        <name evidence="23" type="ORF">Hamer_G005696</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Photoreceptor required for image-forming vision at low light intensity. Can use both retinal and 3-dehydroretinal as visual pigment. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Signaling via GNAQ probably mediates the activation of phospholipase C.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Interacts with GNAQ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Cell projection</location>
            <location evidence="18">Rhabdomere membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMW0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15079">
        <property type="entry name" value="7tmA_photoreceptors_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000044">
        <property type="entry name" value="Opsin, ultraviolet-sensitive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001391">
        <property type="entry name" value="Opsin_lateye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00238">
        <property type="entry name" value="OPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00578">
        <property type="entry name" value="OPSINLTRLEYE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10 20" id="KW-0157">Chromophore</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11 20" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4 20" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="6 20" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="15 20" id="KW-0807">Transducer</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="22">
        <location>
            <begin position="94"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG7157296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="399" mass="45634" checksum="014575D94AED2A77" modified="2022-05-25" version="1">MSYSFSGFKERHRQAARALKSIDKMSYWDNPANMVSNSLPSTNPYGNYTVVDTVPKEILHMVDPHWYQFPPMNPLWYGLVGFWMVVMGTLSVFGNFVVIWVFMATKSLRSPANLLVVNLAVSDFLMMLTMFPPMVINCYWQTWILSATFCELYAFFGSLFGCVSIWTMLWITYDRYNVIVKGVAAEPLNSKGAMLRIFFTWTFAFAWCLPPFFGWNRYVPEGNMTACGTDYLTEDVFSHSYLYIYSVWVYFVPLIVIVYSYTFIVKAVAAHENQMREQAKKMGVKSLRSEEAQKTSAECRLAKVALMTVSLWFMAWTPYLIINYAGMINKSHVTPLFSIWGSVFAKANAVYNPIVYAISHPKYRAALEKKLPFLSCATEGRDNHSESASTVTNEKSESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MN64</accession>
    <name>A0A8J5MN64_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding nuclear phosphoprotein p8-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036987">
        <property type="protein sequence ID" value="KAG7157688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MN64"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018792">
        <property type="entry name" value="NUPR1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10195">
        <property type="entry name" value="Phospho_p8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="121" mass="13621" checksum="0BD2D7E6400010CE" modified="2022-05-25" version="1">MSDAYFDEYDHYNFDDKLVHSRGSGKNRSKQEAEQNKHHNDTDGHTRASMKVMVVITRLGGPREEVASAVGCHAARPPWRAFVDRIVDAEPKLKVTDNGFGTPLGCMGHHYAEEDLKHTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNF7</accession>
    <name>A0A8J5MNF7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TBC1 domain family member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TBC1D1-L</name>
        <name evidence="1" type="ORF">Hamer_G014822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035946">
        <property type="protein sequence ID" value="KAG7157958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNF7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="175" mass="19797" checksum="1AC505912BCBB527" modified="2022-05-25" version="1">MIMREVITGRKSIGLAENRKPQCVYSDHGIKNNDHFGFICRELNGETACYLGYVFKCQMSSVTDEIMQALSKAFAAVHEAQVRERQENLLCDQCPMKWFSQLCSEVEGLPAAKAHITIMKRLSFLPTEEKSILIVYEGAETTDIQVQNNILMMLLRAHFENKQATHSILPCLVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNS8</accession>
    <name>A0A8J5MNS8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Lutropin-choriogonadotropic hormone receptor-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Lhcgr-L2</name>
        <name evidence="15" type="ORF">Hamer_G008844</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15136">
        <property type="entry name" value="7tmA_Glyco_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000181">
        <property type="entry name" value="Thyrotropin receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF74">
        <property type="entry name" value="LP13728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="837"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="869"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="914"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="955"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="999"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1052"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="849"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="79"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="511"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="692"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1221"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1272"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="692"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1232"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1273"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1298"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7158209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1317" mass="145561" checksum="59285FB37BA910A8" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPZ1</accession>
    <name>A0A8J5MPZ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G-protein coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Hamer_G016629</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPZ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053093">
        <property type="entry name" value="GPCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47760">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR B0563.6-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47760:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7159232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="192" mass="21392" checksum="DC08EB265E9F71C5" modified="2022-05-25" version="1">MTTTPLSLSFPPAGYAAASFALLCAIPFTHRVLTHEGGVWSSYYLAAFHAHVVLYFGNSCIGIGVVMLLALTVERFISVCYPAQARNLCGTTRAYVTVSAYKWLLELAFKLVPALILVYLNVRIIRTYKAVCEKRRKMTNKVSGEQRRQYAEESRLMFLLGGTSTLFFVCMTPRSCSPSPYTRPGDTLLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQ37</accession>
    <name>A0A8J5MQ37_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short transient receptor potential channel 2-like protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G004186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQ37"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002706">
        <property type="entry name" value="Xrcc1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11370">
        <property type="entry name" value="DNA-REPAIR PROTEIN XRCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11370:SF4">
        <property type="entry name" value="DNA-REPAIR PROTEIN XRCC1 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01834">
        <property type="entry name" value="XRCC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-repair protein Xrcc1 N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="672" mass="75482" checksum="45195BF29DFD786B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR67</accession>
    <name>A0A8J5MR67_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR67"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="101" mass="11188" checksum="C1C2CD06A554CEDA" modified="2022-05-25" version="1">MAHDSKKDHIFPKTHEVGLRYTSAQRESRTGGSNITLEGIAILLTLTFLVRVIADIISRVRNGRSLRRSADDEVDILSHRVMTALSTVEQVLGQALLDHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MT15</accession>
    <name>A0A8J5MT15_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein Xfin-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Xfin-L1</name>
        <name evidence="10" type="ORF">Hamer_G008021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MT15"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002104">
        <property type="entry name" value="Si:ch211-266d19.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000417">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000597">
        <property type="entry name" value="zinc finger protein 236 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056438">
        <property type="entry name" value="Znf-C2H2_CTCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23611">
        <property type="entry name" value="zf-C2H2_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7162472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="356" mass="40651" checksum="845137DE9A591FE1" modified="2022-05-25" version="1" fragment="single">VQLNSEDQSCSARESAGTAKVPTSLRKLQQFPSQNRTANSNSPIVQNIEQLQEKPYSCTLCSFRTAYQSNLTAHQRTHTGERPFLCPYCPSQFARKSHLKQHLSTHTGEKPYACQYCSYRSSRMSYLKRHMETHTGLFPLSVSPFDAIVRISKISLAKTLNSDDLSSTSITKLSTSFWVVPFHKWHIILELEQLNNEDQMSSSQGLLAAVRVSTSGGKLYHFPSHNSGSESEATSVQKPASFIPRKPYLCTQCSYQTKHKHHMTYHQRTHTGEKPFLCKHCPAKFTKQSQLTQHLRTHTGDKPFSCPHCPACFARKSTLKHHIFLHTNMQPHACQFCSYQTKQLYHLRKHLKTHMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MT59</accession>
    <name>A0A8J5MT59_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ras-related protein Rab-2A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Rab2A-L</name>
        <name evidence="1" type="ORF">Hamer_G004415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MT59"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="43" mass="4825" checksum="AA359240C6364C01" modified="2022-05-25" version="1" fragment="single">MVIMLIGNKSDLDSRREVKREEGEAFAREHGLVFMETSAKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUD3</accession>
    <name>A0A8J5MUD3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">Adenylosuccinate synthetase</fullName>
            <shortName evidence="9">AMPSase</shortName>
            <shortName evidence="9">AdSS</shortName>
            <ecNumber evidence="9 11">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">adssl1a-L</name>
        <name evidence="13" type="ORF">Hamer_G002880</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9 11">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9 11">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 11">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="9 11"/>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUD3"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
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            <position position="62"/>
        </location>
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            <position position="167"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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            <begin position="59"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
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        <location>
            <begin position="61"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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            <position position="61"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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            <position position="156"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
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            <position position="170"/>
        </location>
        <ligand>
            <name>IMP</name>
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            <note>ligand shared between dimeric partners</note>
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            <position position="248"/>
        </location>
        <ligand>
            <name>IMP</name>
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            <name>IMP</name>
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        </ligand>
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        <ligand>
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        </location>
        <ligand>
            <name>IMP</name>
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        </location>
        <ligand>
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        <location>
            <begin position="438"/>
            <end position="440"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00050432"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7163657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="450" mass="49689" checksum="A075617C40AAF372" modified="2022-05-25" version="1">MADVNGVQPESPRKRLRQEPSNKVSVVLGAQWGDEGKGKVVDMLAGSSDVVCRCQGGNNAGHTVVVGDAEYDFHILPSGIINSSAVSVIGNGVVVHLGQMFEEIQKNETKGLKDWQKRLIVSERSHIVFDFHQSVDGLQEQERSKDSSGTKSLGTTKKGIGPCYSSKAGRHGLRMADLLGDFSVFEQRLRNLVDSHKRMFPELTVDVEEEVRKYKGYAERMRPLVANTVAYIHKCLQGDKKVLVEGANAAMLDIDFGTYPYVTSSNCSIGGVCTGLGIPPQYIGEVYGVVKAYTTRVGVGAFPTELDDDIGKLLQNRGAEFGVTTGRPRRCGWLDVVLLRHTNMVNGYTAIALTKLDILDVLKEIKIGVGYLKRNGEKMEHFPANMGELEDIKVEYIIMPGWQQDTAQCRTYEELPQNARNYVEKIEELVCVPVKWIGVGKSRASMITIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MV38</accession>
    <name>A0A8J5MV38_HOMAM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G005141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958:SF6">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="197" mass="22493" checksum="B86C17D770D8B4E2" modified="2022-05-25" version="1" fragment="single">MDHHSKKVQSLSVFWNTEEKDEEVARMLGSLPGLDWRKPVFFSISPKTISSKYSIPEGFYLDTLRPKDTPTVMSSWKYRWTESQTGLETLLQSVPSVALRKRGDSDPASEDQLVGWCYLYNNGMLGNKFIVPEYRGQGLSSFALRLIPKIYRDGLLPYFAFSTSYNRDGVKFEELGFVKGMDMEAVFYLPKGKTVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5MXA6_HOMAM</name>
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        <submittedName>
            <fullName evidence="1">Putative extensin-2-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G018354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7167930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXA6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="958" mass="108118" checksum="353CA59DE8E5970F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYR1</accession>
    <name>A0A8J5MYR1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020277">
        <property type="protein sequence ID" value="KAG7168262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYR1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="78" mass="8966" checksum="17D84F218BD23A6C" modified="2022-05-25" version="1" fragment="single">MRNSKPLKKTEPEQPNADFRDTANAAPGVSYLLQEAPYPLERRYNIPRVRHFPEQTSDPRSKGVGERGQMQLMILQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZ49</accession>
    <name>A0A8J5MZ49_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">LIM homeobox transcription factor 1-alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LMX1A-L</name>
        <name evidence="13" type="ORF">Hamer_G020849</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019607">
        <property type="protein sequence ID" value="KAG7168682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZ49"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09371">
        <property type="entry name" value="LIM1_Lmx1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000006">
        <property type="entry name" value="LIM homeobox transcription factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000103">
        <property type="entry name" value="LIM homeobox transcription factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF166">
        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1 ALPHA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 13" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 9" id="KW-0440">LIM domain</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="12">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="12">
        <location>
            <begin position="132"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7168682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="410" mass="46804" checksum="717BB31C7B1047A0" modified="2022-05-25" version="1" fragment="single">GVEVCEGCGRTIHDRFIMRVIDTSWHEDCLVCCVCRVQLQHSCFARDNKIYCKLDYDRRGEVGRRGREGGEERKKEEGREREDKEVVRRKEEGRKGEKELKHFYWLLVSSISELPECAKWFQLAHVDRLFSVKCAGCGDRLLPHELVMRAQSLVFHLHCFACVVCCQVLQKGDQYVLRGHQLFCRADYEKEMFLLQQHGPQSPLGDDFIVDDGSRPRDGRRGPKRPRTILTSAQRKQFMASFSVSPKPCRKVSLIPHLASPLLPHMTQCPTECRQPVGWGEQEPEGVGVGAFGVVVQHLVWWCSTWCGDAALGVVVQHLVREAGRAKWLGGVIVFGLPHCEVVGEALLSVYLSIYVFFFVSFSFFFVFVSFSFSSVFVFLSYLRISYYSPQTPDNICTAIHHTPVAEFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N060</accession>
    <name>A0A8J5N060_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014229">
        <property type="protein sequence ID" value="KAG7170420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N060"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7170420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="82" mass="9022" checksum="0F6BB5F390AF526C" modified="2022-05-25" version="1" fragment="single">RRVRAVGPARRQHQWALERGRVIRVASARRGAWSVPVDPEKTIFRQRDKVCASYCLVPGVVLTPSLNCTVQLDGPQSGSSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0J3</accession>
    <name>A0A8J5N0J3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G028174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013340">
        <property type="protein sequence ID" value="KAG7170840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0J3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7170840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="303" mass="34037" checksum="765F04CDBA65D03F" modified="2022-05-25" version="1" fragment="single">ARAVSETEKWETTNETVVSSVVLAELVSYIEGTIDDKISAPFFKLSDLVKLYTQRMEQHGIKLNQRVHSIRLKERILAQFPNMQEHNKGCDILLAFEDDIGDALAKACDYDHDNDAVHLLRAAQIVRRDMSTEGQGFTGSFSDKCQENSVSTLLMTLVSMILKGPSIDSPRQLTTAFLSLASTPSELPDGVLSTLERFIVLLYDRRNTCCDVNVLRKKLFSRKSRSLEHLPPTRAALEQHIKRAAYQAGHIWGQDAIAFVNLPSPCDWGWMKSGDELEPLWTTLSEVSTKSCHELISCGCRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0Q6</accession>
    <name>A0A8J5N0Q6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014436">
        <property type="protein sequence ID" value="KAG7170286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0Q6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="162" mass="18044" checksum="5ED663E0A3109063" modified="2022-05-25" version="1">MEPFKDFVAATDFDGAPSGWAWVGGSTEGWGGVWAWVDGSLMKELPWLYSQRTGGGVARRGQRHNVDVHRRDLVIIQDQIKVIGMRSPGSSHKDDVTKIMSQGRGHQDQVTRMRSPGSSHKDDVTRIKSQGRGHQDQVTRMMSLGSSYKDEVTRIKSQGRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0X7</accession>
    <name>A0A8J5N0X7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Jerky protein-like 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">jrk-L25</name>
        <name evidence="5" type="ORF">Hamer_G031266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013913">
        <property type="protein sequence ID" value="KAG7170557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0X7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF26">
        <property type="entry name" value="TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="61"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7170557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="300" mass="34373" checksum="0383AB3A60CEA5F6" modified="2022-05-25" version="1" fragment="single">MASAGPPPPERNLSLPGPSGTKPKKTRRSLSYEVKYTIIQELIWRSSMEHMKITKSTGASMIKYFHNQLLLKTEKLLVRYLVRQARRNMAVDTRSVKEYARELYIAVARKMGTTEPKPFNASSGWLQRFKIRNKITNINIGGEEASADRAAAREFPPFLREIMEEGQYSDDQVFNMDESGLFWKKLPSKSFVVKNASKIRGRKMQKECITVLFTTNASGTSKLKLSVIHTACKLHAYKTMDMTKLNVHWLTARKAWMFSTLSLSWFDDCFVPDVKKFCERQNVPFKILLLLDNAPGHSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N111</accession>
    <name>A0A8J5N111_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peripheral plasma membrane protein CASK-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Cask-L1</name>
        <name evidence="2" type="ORF">Hamer_G012598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7171019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N111"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="131" mass="15081" checksum="8E9EA0E8C7607CC0" modified="2022-05-25" version="1">MMADIAANEYLEYGTHEDAMYGTKLETIRKIHGEGRMAILDVEPQALKILRTAEFAPYVVFIAAPSLQNMTDYDGSLERLAKESDMLKQLYGHFFDLTIVNNDIEETIRQLEKSIETMNMTPQWVPVSWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1L9</accession>
    <name>A0A8J5N1L9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquinone biosynthesis O-methyltransferase COQ3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Coq3-L</name>
        <name evidence="7" type="ORF">Hamer_G014717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1L9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="3" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="6">
        <location>
            <begin position="157"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7171581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="303" mass="33059" checksum="EA4FF216DDF84C65" modified="2022-05-25" version="1">MGGYEKHGRPGLDPELVSTTTDSQQPSTISTQKSSAGHPATNSVRDTDTAGISSTLSSQGYSSSSSSSSDEYSNGNSSSDENSKNENSRSKSTYIEEEVAKFRAMADSWWDLQGDCKPLHSLNRLRVSLIREGLVQSRITKQEYIDGPRPLTGLKILDVGCGGGILCEPLARLGARVVGLDAAKENISVARLHADKDPRVSQNIEYIYGTIEEHAENIDDKYDAVVASEVLEHVDAIDLFINTCADTIKPGGSIFLTTINKTTFSWVGAIVIAEYMLHLLPTGTHDWNKFVTRQDLLFLLEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2B0</accession>
    <name>A0A8J5N2B0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2B0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="134" mass="15378" checksum="86F5F36AB8D88F8A" modified="2022-05-25" version="1">MVDDLTPCTLPPRNCEVFSVCEFWKKYNIKNAAVRIIEAWRQINVATVLHAWKPLFINSEISGAEQTKASRKRQSMEATLMDTVEEAQSVPAPGFSDVQVEDLQKIVGQHQQQRTIEEMLEEDKEHQPTHEDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2F5</accession>
    <name>A0A8J5N2F5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tigger transposable element-derived protein 1-like 202</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TIGD1-L202</name>
        <name evidence="2" type="ORF">Hamer_G000840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2F5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="252" mass="29132" checksum="F81754B5B5EF04A8" modified="2022-05-25" version="1" fragment="single">WKEVTVRCLCAAWRPLWPECVLQRDFEGFEELEEEAVVHEIVSLGNSMGLEVDDDDVEELVEEHSKELSTEELLELHKEQNETLKRSLTSEESGEEEDKEESRIIPAKDLKDAFFCWSKLSKLAEDYHPDVGSVQKAISVFNDNVMNYFWKVQKSSYIIKDATANIALVWKSVPETALNGVWHNLWREVVHDFKGFDEGKDELRGEPGFQEIQEEDVNELLVSMEDPLTSEEVLEMAKKHEEEEEATDSPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4B4</accession>
    <name>A0A8J5N4B4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Cul1-L</name>
        <name evidence="11" type="ORF">Hamer_G008557</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4B4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902532">
        <property type="term" value="P:negative regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010564">
        <property type="term" value="P:regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000161">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000019">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000023">
        <property type="entry name" value="cullin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1030.10:FF:000001">
        <property type="entry name" value="Putative Cullin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1030.10">
        <property type="entry name" value="Ring Box Chain A, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="10">
        <location>
            <begin position="379"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7173036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="703" mass="81988" checksum="60881738B9BB2DCB" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5D7</accession>
    <name>A0A8J5N5D7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009918">
        <property type="protein sequence ID" value="KAG7173439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5D7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="118" mass="12577" checksum="D95369435FD0B057" modified="2022-05-25" version="1">MYIPTLDALGSPSNAAHAADQDVGRWGRGRPQQLQDLCVVPDPSQAKQASSDTCLTRRIRSVPNTTTSSWDTPHLPPPPSLPPATRVLSPWVTHTPPTPSSEDQGGAVPPPAQCVRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5I5</accession>
    <name>A0A8J5N5I5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Emc10-L</name>
        <name evidence="11" type="ORF">Hamer_G014569</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010116">
        <property type="protein sequence ID" value="KAG7173245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5I5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22209">
        <property type="entry name" value="EMC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035152365" description="ER membrane protein complex subunit 10" evidence="10">
        <location>
            <begin position="26"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7173245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="226" mass="24857" checksum="E074FE9012408E6C" modified="2022-05-25" version="1">MLRTAYLCRIIFLSFLAVLATGVHGFQEDEFLDGQLTLVVEDALDGGPNPAFSPRSTIHVRSVKSGNALVTHNRQWTTELENKLRKLAENDDLYRIRVHHKGLEDKGYVSTFTKAIYESGLSETVSMMVDSAGTSVVGVGLIPPVAVCRGEPPEVPPVQHNTTVIIRSPTPAPVPDTATYIEKLEAMKNEKAEGKDNRSFLSKYWMYIVPVVLIMVLFGGGQEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6Q6</accession>
    <name>A0A8J5N6Q6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007435">
        <property type="protein sequence ID" value="KAG7174681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6Q6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="106" mass="11242" checksum="1C716FA0142BE8CD" modified="2022-05-25" version="1">MVKVREEEAPCPPADCPPHPTPHLTPTPTTASPHRWGAAPPASSLASGPSVPGLLRQPTEAYCHDDLRPTTAATVPALGETLTPADEHHHTHPPPHYHHYNGSGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8Q1</accession>
    <name>A0A8J5N8Q1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dystonin-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DST-L2</name>
        <name evidence="3" type="ORF">Hamer_G001187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030056">
        <property type="term" value="C:hemidesmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000001">
        <property type="entry name" value="Microtubule-actin cross-linking factor 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000039">
        <property type="entry name" value="Short stop, isoform N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000040">
        <property type="entry name" value="Short stop, isoform N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000042">
        <property type="entry name" value="Short stop, isoform N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF23">
        <property type="entry name" value="SHORT STOP, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2543"/>
            <end position="2567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2875"/>
            <end position="3008"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="360"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="894"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1259"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2312"/>
            <end position="2339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2742"/>
            <end position="2779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2547"/>
            <end position="2562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2991"/>
            <end position="3008"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="3008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="3008" mass="341816" checksum="949B055946655CB0" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8Z5</accession>
    <name>A0A8J5N8Z5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G015218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7175009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8Z5"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000038">
        <property type="entry name" value="Si:dkey-10o6.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="176"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7175009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="318" mass="35491" checksum="92C3CD1F3671A2E6" modified="2022-05-25" version="1">MKDHKQQRSTTNIPVVDLGELGVGGPEDPSDEVLQRLGEELVQAFSSIGFVYLSNHGIPAHKVEEINSCSEKFFMLESSTKLKYKRGVADIQGYTEPGQEKLTTKDDVRELRESYDVRLVDGVFPDKEVGSLRPAVRDLVTSCKLLSLRVLTALAVGLGLERSFFVSTHQEMCSNSNATCLRLLYYPPVPPTFSVGATRCGAHTDYGTITLLFQDNIGGLEVRDREGAWVSADPVPGTILVNVGDILQFWTSDKLRATEHRVLIPKEEMHQKSARRSVVFFVHPDDPVLIKALDGSSTYNPITAKDHTEKRFEETYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9E3</accession>
    <name>A0A8J5N9E3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spondin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Spon1-L</name>
        <name evidence="1" type="ORF">Hamer_G016924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7175975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9E3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="95" mass="10912" checksum="36B1BC49B39E7064" modified="2022-05-25" version="1">MTTLRAARTSWVDLNSHNPPRISLYAPSNVENLRLEKVNCMVTPWGEWSPCSVTCGRGRIEKRRMIKFVSLPSCKVTSFVAFVEVEPTERREEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9Z4</accession>
    <name>A0A8J5N9Z4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G015457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9Z4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="163" mass="18209" checksum="702592590DC7044B" modified="2022-05-25" version="1">MKARQPHAPVLHKLSPDVTLREFKVWRSVWCDYEELLQLRNQLHRIQAHLRSCLTPEMRSTLAHAIGGLRGGPHPISGANPRTDQGASTVQRQRNIALRRVRFEERQQHGGELFDVLKCCPYGTGGGCRVVGDVSGCSTMSCFPGMMRKHNICRPPEADQGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAI4</accession>
    <name>A0A8J5NAI4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G009857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAI4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="123" mass="13129" checksum="86BD73B5964A0748" modified="2022-05-25" version="1">MDKTGGATDGATDSEDEGLEDVLRRCIRSIPLSSSQQQEDEVLDNPIISGFSRGQEYEEFIPVEYQGEDYGTSNQGELGSGSSQDDGPSLSLSSSSSSAADADEDDNQHDKKDEEETSGGNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAL2</accession>
    <name>A0A8J5NAL2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BCL-6 corepressor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BCOR-L</name>
        <name evidence="4" type="ORF">Hamer_G009912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.40">
        <property type="entry name" value="BCL-6 corepressor, PCGF1 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047144">
        <property type="entry name" value="BCOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038227">
        <property type="entry name" value="PUFD_som_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24117">
        <property type="entry name" value="AGAP007537-PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24117:SF9">
        <property type="entry name" value="BCL-6 COREPRESSOR PCGF1 BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1133"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1166"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="682"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1268"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1347"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1268"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1308"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1347"/>
            <end position="1377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7175879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1488" mass="167981" checksum="69CF780411577043" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAS8</accession>
    <name>A0A8J5NAS8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G016900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7175958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAS8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="74" mass="8693" checksum="9E9F4B93BF377CB6" modified="2022-05-25" version="1">MGRNEMDQCREPGARCRLYIIIKSDSYRVAASRVTHTVYIPQKSDSYRVYPSKSDSYRVYPSKSDSYRVYPSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBI7</accession>
    <name>A0A8J5NBI7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD repeat-containing protein 47-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Wdr47-L1</name>
        <name evidence="2" type="ORF">Hamer_G015447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBI7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="175"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="310"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="346" mass="37695" checksum="E046330D334C0917" modified="2022-05-25" version="1">MGTMEDPAKTGNKDGEAKPRFLAVTALEDVQAVRCAEFHPSGRFYAVGSNSKTLRICSYPKLSDLRVDHVTYQPTVLFKRTKHHKGSIYCLAWSPLGDLVATGSNDKTVKLMRFNPDSCNMDGQEVELTMHDGTVRDMCFIEDTSNKSSLLISGGAGDCKIYVTDCATGTPFQALSGHTGHILALHTWGGAMFVSGSQDRTVRFWDLRTRGCVNVITPAATPTKPGAPVASVCVDPSGRLLVTGHEDSVCSLYDVRGSRCIQAFRPHSSDVRSIRFSPSAYYLLTAGYDNKLVLTDLQGDLTLPLPSVVVAEHQDKVISGRWHPSDFSFISTSADKMCTLWALPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBI8</accession>
    <name>A0A8J5NBI8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G023334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003299">
        <property type="protein sequence ID" value="KAG7176483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="3">
        <location>
            <begin position="1109"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1598"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="975"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1941"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1601"/>
            <end position="1630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7176483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2302" mass="261033" checksum="CFE814A39C892B70" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBK5</accession>
    <name>A0A8J5NBK5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase II-associated protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Rpap1-L</name>
        <name evidence="9" type="ORF">Hamer_G015496</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057989">
        <property type="entry name" value="TPR_RPAP1/MINIYO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25766">
        <property type="entry name" value="TPR_RPAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="7">
        <location>
            <begin position="207"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="6">
        <location>
            <begin position="387"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1/MINIYO-like TPR repeats" evidence="8">
        <location>
            <begin position="1179"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7176677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1392" mass="155564" checksum="D33526F1AFD198A2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBM5</accession>
    <name>A0A8J5NBM5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Intraflagellar transport protein 43-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ift43-L</name>
        <name evidence="4" type="ORF">Hamer_G015357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFT43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBM5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029302">
        <property type="entry name" value="IFT43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33724">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33724:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15305">
        <property type="entry name" value="IFT43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7176558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="171" mass="18708" checksum="7C2F3149A1D608C7" modified="2022-05-25" version="1">MTSCLVEETRESSPRKGRRSMGSDSMGNDDPGVSASPLKTSTSSPREALVSGPPAGRRAGGWANSAKTGGFGPPQEDKRFHHDSDSDTGIVVAVNLVATYKELDSDLLRHAAFSTLDDIDLRQLTNSLANEADIREPDIQWKWDTIFTEVSSELRSEWEPSDETSERETIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBV1</accession>
    <name>A0A8J5NBV1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA repair protein REV1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">REV1-L1</name>
        <name evidence="4" type="ORF">Hamer_G000035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBV1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="22"/>
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            <end position="473"/>
        </location>
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            <begin position="143"/>
            <end position="159"/>
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            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7176847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="514" mass="57524" checksum="8927D0DD1253BAF4" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NC08</accession>
    <name>A0A8J5NC08_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">PR domain zinc finger protein 15-like</fullName>
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    </protein>
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        <name evidence="2" type="primary">Prdm15-L</name>
        <name evidence="2" type="ORF">Hamer_G000145</name>
    </gene>
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        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Multicrustacea</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="PRDM2_PR"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
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            <position position="1"/>
        </location>
    </feature>
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            <dbReference type="Pfam" id="PF21549"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAG7176937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="147" mass="17099" checksum="2B56ED41A5A39AC2" modified="2022-05-25" version="1" fragment="single">CEDCQKSHEGDCEEHGPLKKVADTEVSTRARRSIPHILQLKEEDTHTGVYARELLHKRWQFGPLQAERVLAGSQQVAVEEEIKERFGIVFKITQEEGDYLLLDTQQEERSNWMIFVRPAEESRTEFGGIPIQRGYLFCNYQRNTSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5NCP1_HOMAM</name>
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            <fullName evidence="3">L-selectin-like 1</fullName>
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        <name evidence="3" type="ORF">Hamer_G000422</name>
    </gene>
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            <taxon>Pleocyemata</taxon>
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                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAG7177173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="197" mass="21961" checksum="A8D7607D36CA4E5D" modified="2022-05-25" version="1">MKAAVLLVFVGVIGFVSGQNFHSVRFSPFGGFRRPLGHKQFARPTTGGFNRASSGSGIVDATSGQSEYHFSFKHAPGEKFSGGGARVYCQRQGPQWDAVAISSEEELRFIHGIVGGLPYIWTGGYRTGGRNFAWHNGESFNVQEWSHTGQQQRPQPDNRENQSENCLAILNNFYRDGVKWHDVACHHQKPVVCERHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ND82</accession>
    <name>A0A8J5ND82_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Hamer_G020901</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Decapoda</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7177835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1829"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177835.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="1853" mass="208151" checksum="D0F63D4ECDDF9A27" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDU3</accession>
    <name>A0A8J5NDU3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lamin Dm0-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Lam-L1</name>
        <name evidence="8" type="ORF">Hamer_G020914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001665">
        <property type="protein sequence ID" value="KAG7177848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDU3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF11">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="6">
        <location>
            <begin position="58"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7177848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="195" mass="21918" checksum="D560687CDE64A67A" modified="2022-05-25" version="1">MEIAAYRKLLEAEETRLNMSTSRTISTSTGKETPVRRTPLRSLKCKSTVLEEDTIRKSAFQSTAQSTGDIEIVEGCPDGKFVKLQNKSNKDFSIRGFQIIRTAGEAETTYKFHSKSKVPGGATVTIWSCDTEANHEPPLTIVMKNQKWAVADNMTTRLLSTSEEMAVRESKRETESSSTTREREFQPESKEEEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NE21</accession>
    <name>A0A8J5NE21_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ankrd52-L3</name>
        <name evidence="2" type="ORF">Hamer_G008428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NE21"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="224" mass="24794" checksum="707FC1AC9AA55D48" modified="2022-05-25" version="1">MAQGLEAERRRVGQDSALGEGIDHLVRSLRGATTWVTSWPLPHTNLTSLMVVAATNNCPLTASFLRQAGAKCYLQDDSGTTPLHAALDRQHWHLATLMVKHMRACLYIPSLRQAAPTPVASTPQNTSGTGESIYQEERQHLEELIEKVKDKEEKEQLREVVDEYDGLFIRYQAAAAQPPPVTSPHRLTILSYSLLVSCRRGLLQLTYLLVTVVGVKVDVVVDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T3A3</accession>
    <name>A0A8J5T3A3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Paternally-expressed 3 protein-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Peg3-L10</name>
        <name evidence="2" type="ORF">Hamer_G030035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011429">
        <property type="protein sequence ID" value="KAG7172380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T3A3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="567" mass="63331" checksum="4E1606E5D361C92B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TAI1</accession>
    <name>A0A8J5TAI1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TAI1"/>
    <dbReference type="OrthoDB" id="6360260at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035250968" evidence="1">
        <location>
            <begin position="16"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="161" mass="18294" checksum="343EBB8B4F549BFF" modified="2022-05-25" version="1">MRTLIVVLLAAFVAAEQKREAEPSYGLTSYGRDYEYEHGMSYGHRHGYGYGPEVSYHPYRIHSVSHILHKRDAEPSYGLGYGYGHSVGYGHGSGYGIGYGYGHSINQYPYHGHSYVHSHGIGKRAAEPSNMYGYSGYGYGHHPRYGHSYQHRSVHPYFDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5THR8</accession>
    <name>A0A8J5THR8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LYPLA1-L</name>
        <name evidence="4" type="ORF">Hamer_G009707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5THR8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF68">
        <property type="entry name" value="PALMITOYL-PROTEIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7172338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="74" mass="8258" checksum="F3EBE47566C1CF1D" modified="2022-05-25" version="1" fragment="single">VFQAAISNTGSPIIQCHGDCDPIVPYKFGQITSQLIKKFAGNIEFKTYRGMMHSSCEEEMADIKKFIAKYLPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIK4</accession>
    <name>A0A8J5TIK4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006308">
        <property type="protein sequence ID" value="KAG7175110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIK4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="73" mass="8167" checksum="881DE1E580B6E93E" modified="2022-05-25" version="1">MPWSSFGRERPVEEQERLVEHEEGETQLLSFLGGGWGGGVGRGGGGARARRSLTQLTRRGNRTRDTRLTERDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJZ2</accession>
    <name>A0A8J5TJZ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaJ subfamily C member 27-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Dnajc27-L</name>
        <name evidence="2" type="ORF">Hamer_G023457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009918">
        <property type="protein sequence ID" value="KAG7173432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJZ2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="161"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="222" mass="24338" checksum="05776B9674B47DBE" modified="2022-05-25" version="1">MDSRNGSKHVSRIRILSLGNSGVGKVRSEFYRDMQGIMLTYDVTDRSSFIALDAWLAELRHNLGSPNEWNLTVIVCGTRTDTGGTGGRQVSEADGRGWADKHSFSHVLTSAALGNGISHAFHTLFVQALQMKDGIRQPGVAGGAIDPDIIQAIHRLTHAIDDFDKMGINRRSISRDEVNKAYRRLAALVHPDKCKAPGAEEAFKALTQARNNLLKIMTETTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TK18</accession>
    <name>A0A8J5TK18_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G025662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009683">
        <property type="protein sequence ID" value="KAG7173492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TK18"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="145" mass="16492" checksum="39EDE6631FA76362" modified="2022-05-25" version="1">MKVPVRHKIYKKVIAKQPLHLTHVERVVQDVLSTNYYPEIVTTTVVIPQVRVVTDYEVERVTLYRPVVVKAKKVIPKPVIRHEIEEVVENVVIYDTVTSAVVLPSYETAIQVVYSTVVVPNLIPHIEHVVEYTTIVSTICPGYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TK62</accession>
    <name>A0A8J5TK62_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cuticle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TK62"/>
    <dbReference type="OrthoDB" id="10501951at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035328185" evidence="1">
        <location>
            <begin position="16"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="129" mass="13683" checksum="076704140D91D6BE" modified="2022-05-25" version="1">MRALVVLAVVGVCTAVPFVQDTPEVAAEKARFFQAYQAAQAAAQPQYNAIPHQAYNTGHYNPSHHNLGHYNHAPAQPKWTGPVAATIPAGLPGAGNQVADTPEVAAARQAFFSTYQRQAAAAAPPTLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKA2</accession>
    <name>A0A8J5TKA2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKA2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="75" mass="7908" checksum="3ADCD840214F0A45" modified="2022-05-25" version="1">MMGKTGMAIPEVATPEMITPEMTIPEMSTNEMARPSVAAPEIATPEEAIPEVATLQKTTPQVVTPQAATLKMATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLW0</accession>
    <name>A0A8J5TLW0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7174977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLW0"/>
    <dbReference type="OrthoDB" id="6381258at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035177450" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18673" checksum="7A1B707D938839D0" modified="2022-05-25" version="1">MWSLLFLLTLSVATVHLAIENQFWHASEVSVERVTSMSSTQLGSLIRCAMLATEISWSHLFVFKDGVCSLSDMRVGKYLNDSDLGPTIACHTRHMYVCRTNGYTYADGESLEDTCGYYFCDRGTVGNIMKATTCPSPFTEDAGLGCVYLNKVSMTFCDARKWWEARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TNH9</accession>
    <name>A0A8J5TNH9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L13a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPL13A-L</name>
        <name evidence="6" type="ORF">Hamer_G009946</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="6">Heart &amp; testis</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TNH9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7175907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="214" mass="24553" checksum="7FBAC7B9A2FCC3B3" modified="2022-05-25" version="1">MEIKCGFISNVIFFFQPILIDGAGHLLGRLAAIVAKTTLSGQRVIVVRCEKINISGSFYRNKLKYLAFLRKRCNVNPKRGPFHFRAPSKIFQRTVRGMLPHKTTRGQEALKRLKSFEGVPPPYDKVARKVVPDAMRVTRLKPGRKYCFLGRLSHEVGWKYKTVVATLEARRKVKSTVIFKKRKADMKLRKQAMAKVTKRIEPYTKVLVSYGIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TW50</accession>
    <name>A0A8J5TW50_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Tigger transposable element-derived protein 1-like 307</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TIGD1-L307</name>
        <name evidence="1" type="ORF">Hamer_G003901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TW50"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7178128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="145" mass="16496" checksum="62C2FEBC9E36788F" modified="2022-05-25" version="1">MWKKFSIANCISIKQCHDDLTALCVNSCWRALWPEVVNDLASFPTVNQDVQHIAQLARQVGGEGFDNLQEEDMQEELLGQAGEELAKLDEEQCREDEEEDSEVEDEPTLTVMSLNRGLLATRALVYKFFEANPSIKRSVNFKRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J3K3</accession>
    <name>A0A8J5J3K3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NDUFB7-L</name>
        <name evidence="14" type="ORF">Hamer_G009301</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J3K3"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7153642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="124" mass="14912" checksum="0DEBA8E91D7C6809" modified="2022-05-25" version="1">MGHVFSHYIGDPATTPDYTKEPTFDPLYGFSEGRKERVKLATKEQMESVQLPLDKRDYCAHLAIKHRACRERVWPFTYQCAHEKHEYLNCEYDDYVLRLKEYERERRLLERAKRKAAKVAREEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCV6</accession>
    <name>A0A8J5JCV6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Ribokinase</fullName>
            <shortName evidence="12">RK</shortName>
            <ecNumber evidence="2 12">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RBKS-L</name>
        <name evidence="15" type="ORF">Hamer_G015997</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 12"/>
    <dbReference type="EMBL" id="JAHLQT010041065">
        <property type="protein sequence ID" value="KAG7155625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCV6"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="14">
        <location>
            <begin position="2"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="29"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="201"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="232"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7155625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="287" mass="30264" checksum="BDD1BE022A4449D1" modified="2022-05-25" version="1">MIGSASYTPRLPALGETIHGHRFSVGFGGKGANQCIAATRLGATTAMVAMVGDDSFGQNYLQNFHDNGVNISHVGVTSEAATGDNCIIIIAGANLKMTAANIEKAEKMVKESTVVVCQGEITSEATLAALVMARKHNVTTLMNAAPADANLDPAIIENSVIFCVNESEAEVLTKIQVKRVEDAQLAAKILLTRGCRSVVITLGGDGAVYSTLDEHIYVPADKVTPVDTTGAGDAFVGALAYFLAYHPQLTMEEMMQRSCKIASVSVQAAGTQSSYPTRDKLPSHLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEM2</accession>
    <name>A0A8J5JEM2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neuronal acetylcholine receptor subunit alpha-7-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Chrna7-L4</name>
        <name evidence="5" type="ORF">Hamer_G022009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044850">
        <property type="protein sequence ID" value="KAG7154225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEM2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="4">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="4">
        <location>
            <begin position="158"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7154225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="225" mass="24789" checksum="D0FB4F1EBEB54583" modified="2022-05-25" version="1">MVEWQDHNLMWNESDYGGVADLRIPPKYLWTPDVLMYNRTSSTGEARLSISEYEGEEPGQLSGSVRVRSQVKCLVWRGEEPVKCLGGEGEEPSQVSGSVEGEEPGQVSGSVRGEEPGCLGVWRVRSQGRLWECEGEEPGQVSGSVRTNVGVVPSLPTSADEGFSSTYPTNVLVDSKGICTHIPPGIFLSTCRIDITWYPFDDQKCNMKFGSWTYDSAKVCFSSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFK3</accession>
    <name>A0A8J5JFK3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Pigv-L</name>
        <name evidence="12" type="ORF">Hamer_G015010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFK3"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7154660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="297" mass="33416" checksum="CBB817669A1DD772" modified="2022-05-25" version="1" fragment="single">AVSNLIIPDHQADAFVSPEDPDLPASWPDQVQGPSGWIARSNGLVNVGLSLYRKLQDCSTYFYKIRNATESGQLSLLLVLVLTFNYTLIPLFIGLFSLYYHLLSSRCGVTVQLVLASGEKRGIQIDAKPDTLALVTTRLLCSSCPVVYWFAAHLITDHPKRSTGTISKENTDDRPECITNMTKRYTVFLLSEFPKPFWGQVVLSYFFLYFMIGIILYSNFLPWTEFLSLICLSRNDFFCLPASLCFTIMKLLVLDFSLLVVEAFGFMRPFLAPNLSLPSLPARTVSILASLECFLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGF5</accession>
    <name>A0A8J5JGF5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc finger BED domain-containing protein 5-like 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Zbed5-L25</name>
        <name evidence="1" type="ORF">Hamer_G028872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037831">
        <property type="protein sequence ID" value="KAG7157245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGF5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF19">
        <property type="entry name" value="LOW QUALITY PROTEIN: ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="99" mass="11694" checksum="FE808B129B82D285" modified="2022-05-25" version="1" fragment="single">KLKALKAKLRLWKGKIEQGNAASFPLLNLFLKDKEDVSLLDVQNIIVEHLEKLSDEFDRYIPDEELHEKYKWVRRPFDVQVEDLSEEESSILSLQEELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHT4</accession>
    <name>A0A8J5JHT4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038672">
        <property type="protein sequence ID" value="KAG7156809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHT4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="258" mass="27613" checksum="F934945031A2DC67" modified="2022-05-25" version="1" fragment="single">MNDQNSTANESDLKRIIEWSFNDRPHHQQVELDQRTGSSMSNKEGELEGWGEKEGEHPATPTYMASTNSYLYPETFTGIPLKINGHLTSNGGGLSYGNYADHSTVATGQQQQQQQQQQQQQQQQQQQQQPSSPSGGYVMGGNVSSAGGVGSYTHTPPGIVTSSQHSLYPGYGDYDGGHDAPDGVHGFSPGYNNGFANHNFKTSSGSLPLSLHVNSRGNGSVAGNATSTIPRLGIPVDPSQYIVPPRTQVMQGALATHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIX9</accession>
    <name>A0A8J5JIX9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TLK2-L</name>
        <name evidence="17" type="ORF">Hamer_G006525</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIX9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13990">
        <property type="entry name" value="STKc_TLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000037">
        <property type="entry name" value="Serine/threonine-protein kinase tousled-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF23">
        <property type="entry name" value="TOUSLED-LIKE KINASE, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="733"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="280"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="340"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="442"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="608"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1006"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="534"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="670"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1018"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="762"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7156550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1069" mass="118410" checksum="35F839B4DDD0D4E6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ87</accession>
    <name>A0A8J5JJ87_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">H2A-L7</name>
        <name evidence="17" type="ORF">Hamer_G032263</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042222">
        <property type="protein sequence ID" value="KAG7155278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJ87"/>
    <dbReference type="SMR" id="A0A8J5JJ87"/>
    <dbReference type="OrthoDB" id="6351678at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000173">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="16">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7155278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="123" mass="13281" checksum="10379EACE600C6C3" modified="2022-05-25" version="1">MSGRGKGGKVKGKSKSRSSRAGLQFPVGRIHRLLRKGNYAERVGAGAPVYLAAVMEYLAAEVLELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLSGVTIAQGGVLPNIQAVLLPKKTEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JK59</accession>
    <name>A0A8J5JK59_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G011994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JK59"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="626"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="478"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="563"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="344"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7155863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="774" mass="84990" checksum="EEA524D61D483A69" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKC9</accession>
    <name>A0A8J5JKC9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pancreatic triacylglycerol lipase-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Pnlip-L2</name>
        <name evidence="7" type="ORF">Hamer_G015029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKC9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002331">
        <property type="entry name" value="Lipase_panc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00823">
        <property type="entry name" value="PANCLIPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="75"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7154674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="233" mass="26439" checksum="49ABBE6AF30D40D9" modified="2022-05-25" version="1" fragment="single">MEQVLVRSNRMRVWWLVVVAATVQRSQQGFLGEIISGLRDLPVIGNVLRAAVHPIYRPLVRQFQPGITSREGEDELCYEDLGCLLTHDDFFHPIHRPLNLPPNTREEIYVLFTVHSRKDSLGTQVEGINLTRVLTNTTFTPTRKTKIIIHGFLETNTETWMLDMVRTLLVYDDYNVVTVDWSGGSQALYSQATANTRVVGLEVAHFINWLKDNALLDPKDVHIIGHSLGSHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKF3</accession>
    <name>A0A8J5JKF3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027192</name>
        <name evidence="3" type="ORF">Hamer_G027193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031894">
        <property type="protein sequence ID" value="KAG7159851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010031894">
        <property type="protein sequence ID" value="KAG7159852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKF3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036271846" evidence="1">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="150" mass="14077" checksum="C3995F66B173794E" modified="2022-05-25" version="1">MKLLVITVSAALLVGSCMAGGSYHHGSRGGFISHGGNRGISGGIGFDSHEFIGSPVISSGGHGGSYYGSGGRGVNIVRAIGGFVGSSTIGGGYGSRGLGGSVGGGSFGGSIGRGSVGGGFGGPIGGGSIGGGSFIGQRGSIGGGRSYGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKP4</accession>
    <name>A0A8J5JKP4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037363">
        <property type="protein sequence ID" value="KAG7157589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKP4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="196" mass="21987" checksum="6A7FDF7E3893589D" modified="2022-05-25" version="1">MRKATDSQDEVNEINNTNDSNVEDDPASVSGNCPTLPQDPASISRTDIAQQNALSVKQLWKQFHILRVVDHMVAARNKISLATIKHAWRPLLPHPSDARSVVRKRTDLLEAVVESARSVPAPGFLYDAIEEPKHKITAGKLSPALVRTSENRRKTNQRRRSPITRHDTTRHDTTRHDTARHGTARHADTLAVHSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKY4</accession>
    <name>A0A8J5JKY4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-responsive transcription factor-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Carf-L3</name>
        <name evidence="2" type="ORF">Hamer_G018741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036987">
        <property type="protein sequence ID" value="KAG7157679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKY4"/>
    <dbReference type="OrthoDB" id="5984937at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029309">
        <property type="entry name" value="CaRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47456">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47456:SF1">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15299">
        <property type="entry name" value="ALS2CR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="529" mass="62062" checksum="F3C864E71342379E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLE0</accession>
    <name>A0A8J5JLE0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monomeric sarcosine oxidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">soxA-L</name>
        <name evidence="7" type="ORF">Hamer_G001588</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLE0"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF10">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7160367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="410" mass="46413" checksum="1677CA9B1D42585F" modified="2022-05-25" version="1">MAGSVQMTFDLVVVGSGLMGSAAARHAASIPNTSVCLIGPAEPQTRASRQIFGCWYDEGRVYRRIAAEHTWSVLAQQSVARYTHLEHLSGVRFHEEVGYVHATPDAAEYQELMKCGRDQGLNTLDLTRSWRKHFPFFNFPQESYIFWEKSNAGHLSPRNLVRAQQVVARRCGAQVMPQVVSTVRPAHEPSHRWEVVTEGGEVVRAWRVLVAVGGSASLRPLFRHVAPGLQPHLQLRTQTVAYFRISDQEAHRLRYMPTLFTNCRFEDLDGGYALPPIKYPDGRWYLKVSHNRRHEEVLVTEDQVTKWYRRATGIPECVAKLTRFLHHLLPDVQFEEVSGDGCLTSHTPNQEPYIDIIAQGFGVALGGNRWAAKSSDEIGRLAARLVVLGEWESEVPRERVKIIWTTQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLI9</accession>
    <name>A0A8J5JLI9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carcinine transporter-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CarT-L2</name>
        <name evidence="2" type="ORF">Hamer_G008851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLI9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="215" mass="24981" checksum="D04C97091BA38D74" modified="2022-05-25" version="1">MAKEFDEILESVGSYGYYQKWMILIFFMPISFFVGFTMNLMLFQVVVPDHWCYVPGRENTTLSPKEWRALTLPRAIESEKYSSCLMYKGEWSEDDGANYTVTNETQECISGWQHDLSQFTTTLSTAYEWVCEREIYSQHVLSITMAGNTVGTFLFPLLADKYLGRHSVFFLTLAIHIVFTLPYCWVSNIGLHLTLRFFQGLSFESNYLMPYTIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLN1</accession>
    <name>A0A8J5JLN1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7159945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLN1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="78" mass="8845" checksum="83709F31D136E6DA" modified="2022-05-25" version="1">MEREYFTWGMTENLYEDLDHELFPLLATSNDSTCARFKLFDESKDGSQNQGWDLGGVFGCDLLVTVKKSVLGSVQGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMK5</accession>
    <name>A0A8J5JMK5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Voltage-dependent L-type calcium channel subunit beta-2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Cacnb2-L1</name>
        <name evidence="5" type="ORF">Hamer_G001628</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMK5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11863">
        <property type="entry name" value="SH3_CACNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11824">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="227"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7160395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="341" mass="37513" checksum="04F0A483BCBF11CA" modified="2022-05-25" version="1" fragment="single">VFYLEIVHTLEVFYPDHTRGVHTGVFYPGMFTLEVMITLEVFCPGGILPWGVSTLEVFTQGCSTLGGVHTEVFTLRCLPWRVFYPGDVHTGGDHTGDTLEVFYPGGCSTLECSTLEVFYPGGVLPGGDHTGGVHTLEVFYPGGACHRCSTLEVFYPGGVLQRKCSTLEVFYPGGEFYPGGVLPWRCSTLEMFTLEVFTLEGPHRDGRVKRRTEGQAFVTLQQARTKPVAFSVRTNVAYDGSLDDDSPVHGSAISFNVKDFLHIKEKYDNNWWIGRLVKEGSDVGFIPSPVKLENLRLQQSQQKSSKLYSSKTSSSGNLGMINDVLSNSKSSNSRGSTPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNS1</accession>
    <name>A0A8J5JNS1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminopeptidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lap-2-L</name>
        <name evidence="6" type="ORF">Hamer_G019783</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036095">
        <property type="protein sequence ID" value="KAG7157918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNS1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF48">
        <property type="entry name" value="DIPEPTIDASE B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="340"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7157918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="469" mass="50063" checksum="15CA0863984C3A0E" modified="2022-05-25" version="1">MSTQRVPCEVKAESSLSAAGYDGIILVTDSLDKLKGSLNVLLAPLQAQAAFDESLAKDGACVSVNVPANRLVYAPTGLLNRDYDDVRRFSDAAASGIKRALKVGMKRPLLVRAPDQSFQHADLITLLGALHALYVPIEVREDVPSKASKVSVLGFLGDNKTVQLALALESGRSVARDIGGSDPERMAPPRVEEYVRSVFRGTKVSVEVVSDDAKLCKDYPLFSAVNRCAKGVPRHQGRVIYLTYEGAGPIEQTLMLVGKGVTYDTGGADIKAGGIMAGMHRDKCGSAAVAGFMQILTKLQPQNIKVIGSMAMVRNSVGSDCYVADEIITSRAGVRVRVGNTDAEGRMAMADVLCHMKEMAGKEAAGEQVADPFEISSIRREDYDFHCGKSEYEDVLQCNNLPSSRTPRGHQSPSAFLVMASGLDKHGKDSNQSLKYSHLDIAGSSGPFPGIPTGAPILAMAKAFIPSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JP08</accession>
    <name>A0A8J5JP08_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cysteine/serine-rich nuclear protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CSRNP2-L</name>
        <name evidence="11" type="ORF">Hamer_G006571</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AXUD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JP08"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031972">
        <property type="entry name" value="CSRNP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023260">
        <property type="entry name" value="Cys/Ser-rich_nuc_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580:SF9">
        <property type="entry name" value="AXIN1 UP-REGULATED 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580">
        <property type="entry name" value="TGF-BETA INDUCED APOPTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16019">
        <property type="entry name" value="CSRNP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02031">
        <property type="entry name" value="CYSSERRICHNP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="10">
        <location>
            <begin position="412"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="175"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="475"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="625"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="176"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7156594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="713" mass="79569" checksum="5F9AE61C99F4A9DF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPI0</accession>
    <name>A0A8J5JPI0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mnmG-L</name>
        <name evidence="6" type="ORF">Hamer_G014158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPI0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="5">
        <location>
            <begin position="412"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7161595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="497" mass="55596" checksum="CF13246B44887717" modified="2022-05-25" version="1">MQVMLRWCRAAGRAKHVCQYSRCTPGGAFDVVVVGGGHAGTEACAAAARMGATTLLVTHKKSTIGEMSCNPSFGGIGKGHLMREVDALDGLCGRVLNRSKGPAVWGPRAQIDRALYKKNLQEELFQLPNLTIIEAAVEDLILREPYLEMHQLLGWPTLLKSCSLDLEDLRQPEEQLFCHLTHTTPEVEKIVKDTLHKNRHVHEETNGPRYCPSIESKVLRFSGRNHQVWLEPEGLDSGLVYPQGLSCTMPPEHQQALLRFIPSLQHCEMITPGYGVEYDYVDPRELTPQLETCRVARLFLAGQINGTTGYEEAAAQGIVAGINATAKAFNKEGLTVDRTEGYIGVLIDDLTTQGTSEPYRMFTSRSEFRFQLRPDNADLRLTEKVEQLAKVDSRYEKFTYNPVLTERLKVEALYADLVAAQSEDVDAVRRDYALVIPHNIDYYSPSMSLSNEMRSKLSQARPTTIAAVTRIEGITPAAMISLLRYVKQRQQQYSELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQM1</accession>
    <name>A0A8J5JQM1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034167">
        <property type="protein sequence ID" value="KAG7159043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQM1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="60" mass="6685" checksum="2E0A482A0EC7C970" modified="2022-05-25" version="1" fragment="single">GAGESDGTIYGTMTRQHGTVRGHPCPSTTRRFSFTAHQVMDEYRNTSRTTKLCIDKPINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQU0</accession>
    <name>A0A8J5JQU0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bric-a-brac 2-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bab2-L7</name>
        <name evidence="8" type="ORF">Hamer_G024238</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031019">
        <property type="protein sequence ID" value="KAG7160676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQU0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016199">
        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008406">
        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035167">
        <property type="term" value="P:larval lymph gland hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007526">
        <property type="term" value="P:larval somatic muscle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045476">
        <property type="term" value="P:nurse cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007464">
        <property type="term" value="P:R3/R4 cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045467">
        <property type="term" value="P:R7 cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF111">
        <property type="entry name" value="LONGITUDINALS LACKING PROTEIN, ISOFORMS F_I_K_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="73"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7160676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="367" mass="40086" checksum="70CF6C4EDA9482C1" modified="2022-05-25" version="1" fragment="single">CVLLADAVNFGDVDIDYEELSDAPPVSETLDSSQVYPTSSTASPPNSEQLYRVHYQDHVSTILAALAKDEVFMDVTLIAEGRPIKAHKSVLSAMSLYFHDVLRDNPCQHPIIILPHDVLYEELVDLVTYIYKGEITVALDKVSSVLRVAKILQINGMASVSSVSVDGSSDAHYTTSPETKPFKNTSQGFRPQNILSRVTSQNNSAQVDHKSNLGRPVKRKQHHVTTTPSHQTDLSVTQNVTKCKKFSNKQNTSSLRSHPQTFSSTLTNVSPPAASLSNNSLTLTNVMYEVSSVGGTLVNESESIPGFSETTPGDSVVIRTANKRTLPPETDSSATDPRASHNTNMDMAFVDIGNIKEELIDVDEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRV0</accession>
    <name>A0A8J5JRV0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRV0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="256" mass="29027" checksum="74F87C6D05B72075" modified="2022-05-25" version="1">MAKIQPQNTTEAPQSTFVWGQQQRKAVNPTLTPPQMSEDSFPALPPPGYRTKLKTPGQNQSCTSVKAQNTPVMVENTILPGTLQPPQATTQLNTPQPANLQAAFTEEQIKQMITIMIVTIYYNTETRYQHRKYNNAVMTQLTEKMQEDQTPKSPQLRVEQTTPLSQISDKKNLPSERSLKTVKLQAPCNRSRETATNEHIISNGRGERLNHERRKQLQHQRRGDNDRIAPPPCHLKINSGMYKACPTNGKLYKQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTU3</accession>
    <name>A0A8J5JTU3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Remodeling and spacing factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RSF1-L</name>
        <name evidence="10" type="ORF">Hamer_G014258</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025553">
        <property type="protein sequence ID" value="KAG7164131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031213">
        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15543">
        <property type="entry name" value="PHD_RSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF16">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <property type="entry name" value="Insect_cuticle"/>
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    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035206328" evidence="4">
        <location>
            <begin position="16"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7166352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="173" mass="19289" checksum="E4D8FA2BED6CDC82" modified="2022-05-25" version="1">MKVVLALTLVAVVVAAPYRPRYGHSPIPSYRPAHYRPVPSYRPTPSYRPTPSYSPTPSYRPTPAYRPTPSYAPAPSYSPAPSYNTVPHYTYNYAVKDDYSGNDFGHQENRDGYDTQGSYSVQLPDGRLQTVTYNVNGDSGYVAQVSYQGEAQYPHYQPSYSPAPAYTPRPSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYU4</accession>
    <name>A0A8J5JYU4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 410-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Cfap410-L</name>
        <name evidence="4" type="ORF">Hamer_G003670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYU4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7164463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="540" mass="60448" checksum="6D96553CBC3E0969" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZ20</accession>
    <name>A0A8J5JZ20_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative deleted in malignant brain tumors 1 protein-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028273">
        <property type="protein sequence ID" value="KAG7162009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZ20"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="359" mass="39329" checksum="9A99A1376E811BF7" modified="2022-05-25" version="1">MVEQTTRAMTLPVVCPIGETEASPHLTVSLPHPTPHSESFLTPTLTVSPSSLLHLTVSPSSPLHFTGVLPHSHLSESFLTPTTESPSHSLHLMSPSLTPTPHSGVLPHPYTSVSPSSTPTHHSESFFTPTHHSESFLTPTHHSESFLHSYITARSFHPHITVVFPHSYTAESFLTLHLSDPSHLLHITVSFPHSYTSRESHSTPLHGVLPHPCTSVSPHLPHTSDPSSPPNSQESFLTPLHLSESFPHSHITVSPHPTPHGVLPHPYTSVSPSPLLHITVSPSHTPTHHSESFLTLHPHRVLPHPYTSVSPSHTPTHHSESFPHPYTPVSPSHTPTHHSESFPHSTHHSESFPHSYTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZI3</accession>
    <name>A0A8J5JZI3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methionine aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">METAP1-L1</name>
        <name evidence="8" type="ORF">Hamer_G007263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZI3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="103"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7165431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="329" mass="37154" checksum="3BDF167936D423AF" modified="2022-05-25" version="1" fragment="single">TPWLTQQLDNYLQYFPGYSIVQRAVTQFKNISGASDSNSSQYNPWPYYMFTGSLRPYPQSNKREVPPPIGRPDYADDPNGFPHSEQKLRGSTNIKCLSDEEIEGMRVACKLAREVLDEGVKAAGIGVTTDEVDRIVHEAAVERECYPSPLNYHGFPKSCCTSINEVICHGIPDMRPLQNGDICNIDVTVYHRNFHGDLNETLFIGEVNSIARNLVKTTWECLQKSIEIVKPGVKYRDVGAVIQKHAHSQGFSVVRSYCGHGIHQLFHTAPSVPHYTSTWKDEQWPDNWTAVTADGKLSAQFEETLLVTETGVEILTQRRERNGQPYFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1E9</accession>
    <name>A0A8J5K1E9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1E9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="348" mass="37772" checksum="54B56810B8F2DEA5" modified="2022-05-25" version="1">MGSMESTRSKTEVWLIGQHITEITGAQLPSRGDVLRLFFHGHNEHKKTVNDSASEVAASVISFWNKARIPTITEKSIGRKVVDLFLMWKGLKKNCTRTTDTQRKKEETFCDELEDLFDVAHPKAMQLLTIKEDRAFLAAQREKGRRGVMAGVDKKIACSIKRREESKSKQSLQQNQASSALEYDELGSSSETESQSSSSSSTSSLAISPVVSSSNRKRATLKVITPELSSTLDRTGISHRSALRIVSATAASLAHSNTPSLSKISCLSSNRSLSNSPSLSNTATLSNTATLSNTPTLSTTPILYSTPFLPNSSSITPSPCSTLLPFPPLPPSSNSAFFSNNPSLPLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1M9</accession>
    <name>A0A8J5K1M9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">E3 ubiquitin-protein ligase SH3RF1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sh3rf1-L</name>
        <name evidence="5" type="ORF">Hamer_G002463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1M9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF51">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="240"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7168420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="413" mass="44795" checksum="2C501245F18C98F2" modified="2022-05-25" version="1">MHVINPLPSHIPQCKALYDFKMTNDEERDCLTFNKEIAETVSSSEEEEEGPPLAASATLPGSHTAAPHDSLTPSASATLSGSLTASASAPPPGVPSTSTVTVTAFWKNYNIRQAVNFFVKSWGNATKATVRHAWSALLPQLKPAETKRQQPDLEEMMQEGNTNNVEDLPEHEEGGESGDAASDAGETEQRKVTTQKLSLLLGVFTSLQEMIKVIESESGEREQGEIITVLRRVDENWAEGKLGSRIGIFPLSFVDLNSAAKALMKLSLNYTIIKGEIITVLRRVDENWAEGKLGSRIGIFPLSFVDLNSAAKALMKLSLKNLGCAYLYGEAGDRGGLGLWERTAVKLCLFSRWWRVLGPRRRGATAEGGTIGEEDEGPVLGGEAEVEVGEGKERSGLVTTEDDEEDDSNFETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1Q8</accession>
    <name>A0A8J5K1Q8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G020887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023275">
        <property type="protein sequence ID" value="KAG7165854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1Q8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="186" mass="19710" checksum="7338C5887157A0CF" modified="2022-05-25" version="1">MCTVTAAVKCPTTTSFSTLAWPRASPRFLGLLPTIPPTLRMPQPGPPCPIGSPRGESHRDKCHRPCGTPSAHHACHFSAPPRASVRVWRSHEDEDSIYEEVGFQYLTSPDLDVLGRHPGIDNGSLQNSTASGENLASASATGFLGSDTVVFPNAVFPQKQPRSSAYTGVSTARVASCSLGARGRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1Z6</accession>
    <name>A0A8J5K1Z6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase FkbM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020631">
        <property type="protein sequence ID" value="KAG7168102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1Z6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053202">
        <property type="entry name" value="EGF_Rcpt_Signaling_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009:SF2">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="32020" checksum="465F32423EFFEC49" modified="2022-05-25" version="1">MNRHLKLSRAALCVWATMLTVIQVWVTTSGNTSTLLSSPASSSPADPSSPHPPCPRHCIHQRLHHPLAWWDKRLLHHLQAKMETPPKLSPQHLNGLDPHHPPWEHLFSYNQTEGLLRTIFQGKAGGVFVEVGAQDGLWLSNSWWLEAVRGWQGLLVEADPLNYLQLRASPRTSRILPVCVTADTHIVQVDLLILDVSGGGFEMMTKFLTENKDIGNHFHVKMILYQDNELLQFFSLDEVKENLQEHGYRLIHIKQNHYLLYHESTKIHIMPYNSEPQPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K288</accession>
    <name>A0A8J5K288_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G002898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K288"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7163674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="232" mass="26732" checksum="2594770DBDB43A2C" modified="2022-05-25" version="1">MAAHLLDSNEYTWPRRTPFITTKSKMVSASTIRKILSQEHFILLMTFYMRYTHLFADPKVALIMLVLSLFSDEPGLNDVDAVNLGRQHYLGLLSRYLTAVHGRQGGSEILRALLVSKEEARQLSDIHNHIELHNDIELSPQTRHNLRDMTDTLAVNFQLVCVSAKETILKARATNQTVQKRLSRLSQTVTRRHKHTKNLLARSMSVRPRRKQPWPATSFLHTFCIALQLIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2K2</accession>
    <name>A0A8J5K2K2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024011">
        <property type="protein sequence ID" value="KAG7165685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2K2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="104" mass="11321" checksum="056118450894DF0A" modified="2022-05-25" version="1" fragment="single">MAVVSDSDTSQEVVTESDAPQEVVTDSDTPMEVITDSDTPLEVVTEEDTPLEVVTDNDTPLEVVTEEDTPLEVVTEEDTLLEVVTEEDTPLEVVTEEDSPLEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K421</accession>
    <name>A0A8J5K421_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Macrophage mannose receptor 1-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Mrc1-L8</name>
        <name evidence="4" type="ORF">Hamer_G005450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K421"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7167114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="236" mass="25609" checksum="E7640E157CDC9C99" modified="2022-05-25" version="1">MGEDAEAACVSEGSHLASVKQVRQGAMVWVLSYNQGPPPTPEPPVNGHCPTHDWLDLGGAYCYLAVTDQETWVDASVKYVGGYVWTDGTGLDYINWDDGQPGNDSQNCVEMLTRKGTWVDVDCTTTRAFVCKTEKIPDVHPTPPPTSQPGELMRSLTGGVVGIVLAVVVVVAGFAFLGFYAYTRRTRYSSSHSQLHNVDAVPSLTQAEGGHNSSTTAQPRVCGYTQRVERTIQQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4K2</accession>
    <name>A0A8J5K4K2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Echs-L1</name>
        <name evidence="8" type="ORF">Hamer_G012888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4K2"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7167429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="306" mass="32949" checksum="63F87FF05815D838" modified="2022-05-25" version="1">MAGMAALRIQQLRAVIQPTSFASRIVGCPRANTPNFVQTARSMSSAPTYEHIMVEKRGEGGNVGLIVLNRPSALNALCDPLMKEVKQALLDLEADSCVGAIVLTGSEKAFAAGADIKDMQNKQFVECYNGNFLNDWNVLSIVKKPVIAAVNGYALGGGCEMAMMCDIILAGDKAKFGQPEIVLGTIPGAGGTQRLTKAIGKSRSMQMCLTGDMITAQQASSWGLVSSVHPPDQVVDEAIKLGQKISQHSKLIVAMCKESVNNAYELSLSEGLHFEKRLFHCTFSTNDRSEGMTAFIEKRKPNFTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K596</accession>
    <name>A0A8J5K596_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K596"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="136" mass="15540" checksum="8FA01253387ED39B" modified="2022-05-25" version="1">MLERAKNKRRERASVDVGKKKRPRKCQELGIRICFFCDKSDEEDNLYDFATFDVDINRVLDGAAIVHSLPTAGVSIFEDYGDKAFIPFLTNHLETANRVDIVWDTHIQDNMKKSTREKRGKGVRRKVSGQAKVPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5E4</accession>
    <name>A0A8J5K5E4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor Sox-8-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Sox8-L1</name>
        <name evidence="9" type="ORF">Hamer_G016760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020459">
        <property type="protein sequence ID" value="KAG7168131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5E4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22031">
        <property type="entry name" value="HMG-box_SoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000004">
        <property type="entry name" value="Transcription factor SOX-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022151">
        <property type="entry name" value="Sox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050917">
        <property type="entry name" value="SOX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803:SF5">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12444">
        <property type="entry name" value="Sox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="56"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="56"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7168131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="350" mass="37386" checksum="C98FB65DD23BD959" modified="2022-05-25" version="1" fragment="single">MASDNATTTTTTPVTKNHDKPKEKGIEDAVSKLLEGYDWTLLPMTQKSSLKHRAHIKRPMNAFMVWAQAARRRLADQYPQLHNAELSKTLGKVWRVLSDEEKLPFIEEAERLRSQHKKDHPDYKYQPRRRKPPKSLSSLMEGDTGAPPLSYRVQGGLMGGGGGYCPGVGMSMTLPPSHAHAAPPTPPKTPQHQHNLRVGGSSGSGGVGEGAGRSDCSFGKSTVSASYVRDHHHTPHSHAHFSGLDATKAQLFSQAGSNSSMGGSSTSQYMSDSGSPGARMEAAMALQAARNNFSPSSSSAPSFSPSNSSPGSSTSSTSSAAFFRDDTTANMAANLMRTGHGHEMTICGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5P1</accession>
    <name>A0A8J5K5P1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">celD-L14</name>
        <name evidence="11" type="ORF">Hamer_G020626</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010014925">
        <property type="protein sequence ID" value="KAG7169951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5P1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035248046" description="cellulase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="10">
        <location>
            <begin position="148"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7169951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="229" mass="25142" checksum="6EAE901B0A7B9295" modified="2022-05-25" version="1" fragment="single">MTGVLVKTCLLGAISLSLLYTGAKAQCEHVQVVQQFQGRFQADFIVSAPTDIKGLDLDLTFNTPVDRIEYYSGGATKKDDYNYNLFSQNVNVKEGEQVKASFMVHYSHHMPFVIHEVINGVEICDTTATTPAPMPNPCAETGMMPYDYSQLLCMSFVFYEAQRSGPLPADQRVTWRGDSALDDGSDVGHDLAGGYYDAGDHVKFGFPMAYTATVLAWGLIDFADGYEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5Z1</accession>
    <name>A0A8J5K5Z1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Synaptobrevin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">snb-1-L</name>
        <name evidence="4" type="ORF">Hamer_G013760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012455">
        <property type="protein sequence ID" value="KAG7171302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5Z1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="48"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7171302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="107" mass="11103" checksum="6547D7F5A067AE78" modified="2022-05-25" version="1">MNVMVHRSAEGGAAAAGGAAPGGDPPTGENGEIVGGPRGPQQIAAQKRMQQTQAQVDEVVGIMRVNVERVLERDQRISELDDRAGENPKILASFGSPACQLEGDNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K817</accession>
    <name>A0A8J5K817_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Suppressor of SWI4 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Ppan-L</name>
        <name evidence="3" type="ORF">Hamer_G024305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017232">
        <property type="protein sequence ID" value="KAG7169338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K817"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7169338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="415" mass="47544" checksum="BFDC5B09E32139FC" modified="2022-05-25" version="1">MPRRKMGRLSRRNRDQSRAKQATEERVPQCIVISRAGQLNITHLVAFSQTSVGLYLKVCRIPHGPTLTFRIKVFARSKDVLSSLKKHRVHSGLYITGPCLMTNLQPEGGDLHLQLSARMFLDMFPTITPNQIKTDTIQRCCLINYDPNDGLFDFRHYSINVVPVGISKAVKKFNKRKLPDLSSYNDVSEFMTKAAILSESEAEDDPSAHVMADVKVARRKLGLQKSSVRLSELGPRLSLELMKIEEGLLDGKTLYNRIVTKTDEEKLQLEKKRKHKKQLKMKRKKQQQENVDAKTRKKDEHKKKCLEGMGVGTKKEEEKTKKKRKEEEEDVDDADWEDIEDDDAQKKRKIVAGSGPIRKKFKSADKNTKEGIKKKTKNDNEGMRKTKKNTAAMRSGIRRENLKGRKITQGNYGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KBQ2</accession>
    <name>A0A8J5KBQ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tigger transposable element-derived protein 7-like 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TIGD7-L18</name>
        <name evidence="4" type="ORF">Hamer_G013734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012455">
        <property type="protein sequence ID" value="KAG7171282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KBQ2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF17">
        <property type="entry name" value="TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="58"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7171282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="280" mass="31728" checksum="A23569259C534755" modified="2022-05-25" version="1" fragment="single">MGPKRKHTQLTVAQKLELLQKLESGWSVCLISEAYGSLQSFALKYSPDSSTSKMTVEDHKLMRVEQDQRLEDAVFKWYSQQHSSGVAVHGVEMQMAAEKLATHLGIPNFNASDGWLWRVRRRHGIVNRKVCGEAASTPTDEIKHFRKMLTELIARGLLLSQVYNADETGLFWRSLPENTQAMAKEYSTHGRKLDKAQFSVIGQSTLQNLWKYDIKAAIFNWAAAWKDVKVLTLAKGWRKFDEGDPGFQLMTEEIAASCAASDENDDENEKEDITLFAPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KD69</accession>
    <name>A0A8J5KD69_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glutamate receptor 2-like 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Gria2-L11</name>
        <name evidence="12" type="ORF">Hamer_G016201</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014436">
        <property type="protein sequence ID" value="KAG7170381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KD69"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040128">
        <property type="entry name" value="T25E4.2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22714">
        <property type="entry name" value="PROTEIN CBG02446-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="11">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7170381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="139" mass="15224" checksum="62040F09DFB900B7" modified="2022-05-25" version="1" fragment="single">MSAQGGNGTVSTSPHPPCLRVIAEYFPPFIVTSKTGVVTGAMVEILNLITKKLNYCYEFVLADPDYHYGTRQPNGSWTGVIGQISRGEADMSGSPFAIDFERVEVLDFSVPFVVDKQVAMYKSPVYQADLTGFVKPYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KEU2</accession>
    <name>A0A8J5KEU2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Cytochrome c oxidase polypeptide I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">Cox1-L8</name>
        <name evidence="22" type="ORF">Hamer_G002413</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KEU2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00310">
        <property type="entry name" value="ATP-synt_Fo_a_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF18">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="F1F0 ATP synthase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="10 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="21">
        <location>
            <begin position="161"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG7168384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="403" mass="44287" checksum="3F8E76264F62380E" modified="2022-05-25" version="1" fragment="single">FISPGFAPLCLSLALLLKLGAAHLIFGFPNILCFLLFNIYFISTSVALIFHFQQIFNLSQITSNNASPMLNKILILLSLLSLGGLPPFTPPYHATMIFSTNYKDIANIVGTSLRLVIRAELGQPGNLIGDDQIYNVVVTAHAFVIFFYSYTYYNWRFWELTTFGVISHIVTQESGKKEAFGTLGIIYAIIAIGILGFVVCAHHISTVVGCLTGVILANSSIDIILHGTYYFVARFHYVLSIGAVFGIFPGIAHRFPLFTGVIITFFPQHFLGLNGIPRRYSDYLDAFTARNVLSSIESIISLVAVLSFIIIGTPGLLIPFMVLVETLRNIIRPGTLAVRLAANIIAGHLLLTLLGNIGPSLSITLVSFLMLAQILLLILESAVAIIQSYVFTVLRTFYAREVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KHQ9</accession>
    <name>A0A8J5KHQ9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G020666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013854">
        <property type="protein sequence ID" value="KAG7170575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KHQ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7170575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="62" mass="6778" checksum="6F423126048F8FB7" modified="2022-05-25" version="1">MTHEDKWSTARHRHCSVSPPPLATARLSWCYNPSPFVAKVARIVGAAGRGAVVVGGVEGWWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KNW8</accession>
    <name>A0A8J5KNW8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Double-stranded RNA-specific editase 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Adarb1-L2</name>
        <name evidence="6" type="ORF">Hamer_G023883</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013480">
        <property type="protein sequence ID" value="KAG7170814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KNW8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19865">
        <property type="entry name" value="DSRM_STRBP_RED-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19866">
        <property type="entry name" value="DSRM_STRBP_RED-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000007">
        <property type="entry name" value="Double-stranded RNA-binding protein Staufen homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF62">
        <property type="entry name" value="AT07585P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="402"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="541"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="A to I editase" evidence="5">
        <location>
            <begin position="676"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="494"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="860"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="868"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7170814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="989" mass="108802" checksum="65E9306891F21E1E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MIV6</accession>
    <name>A0A8J5MIV6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucose dehydrogenase [FAD quinone]-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Gld-L12</name>
        <name evidence="8" type="ORF">Hamer_G021856</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047222">
        <property type="protein sequence ID" value="KAG7153247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MIV6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7153247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="710" mass="78481" checksum="AD9CC9B13D542D77" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJT7</accession>
    <name>A0A8J5MJT7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046276">
        <property type="protein sequence ID" value="KAG7153830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJT7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035307745" evidence="1">
        <location>
            <begin position="27"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="357" mass="39619" checksum="F5F4389161FF3D2E" modified="2022-05-25" version="1">MTLQMRASSLVVVVVLTAVAVEDVKPEELSKVLVVPEVSEVKSPAGNSTDRDRFIFGQYSTTTYTNVVMVTSTVFFSCLSGTSAAVCTGRRRKKDLRRFMSIDELPEYDKRSFDLESSHDEDANHEDKQVAYENPESASAQTDTKLFFQVWTTTRTTTTVTLLFTDTNTTIRLSYFCQVGQQQLPTFNSVAAEAVNEKMPEHGVESSDITAKHSPVDEKGEKFFLGGVSTATYTDVVMVTSTVFFSCLSGTSAAVCDGRRRKRSLRSFVKLEEDESSSPLASSQDEDLIGEDLSQAEEENKSSKDEERILGFNIWTTSRITSTVTMLYTDTNTTIRLSYFCQAGQQQLPTFNCVGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLN4</accession>
    <name>A0A8J5MLN4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G022110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040533">
        <property type="protein sequence ID" value="KAG7155782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLN4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058698">
        <property type="entry name" value="CUB_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236:SF5">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26080">
        <property type="entry name" value="CUB_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035168609" description="CUB domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="109"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="237"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7155782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="398" mass="43219" checksum="D07278DBE1DE6C67" modified="2022-05-25" version="1">MMKVGGTWKRLVWVVVIGVVVGVALATPTTEEEQHESLEETQELESEHDRDGKLFVLLAQIAASECTTNDPIRTQGTCMPSKQCSNQGGKSQGTCAKGLGTCCLATRTCNAASSYNNTYFINPDSTDVELGACTLTINRVNSNICQMRFDFISLDLSQPDINGACNHDFFTVTGGVSKVPMICGRNNGQHIYYDVDPNGGTVKLTIDRFDISSLSRSWDIKVTQIACDSRFRAPEGCLQYYTATTGTVNSFNFLNTNTNTDVNGTRQLANEDYGVCIKRADNYCGIIWEASKVGGNFGFTVSGPADAIQLSLIGTINTSTRDGNCTTDYVVIPGGLYTLDDATNTVQAADRYCGLGFPPSVTTTAQPFVLYVKSNGNELMEAINRGFSLNYRQIKTCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLZ7</accession>
    <name>A0A8J5MLZ7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial inner membrane protein Mpv17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mpv17-L</name>
        <name evidence="8" type="ORF">Hamer_G006050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLZ7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901858">
        <property type="term" value="P:regulation of mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7156321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="174" mass="19469" checksum="FA7C9A5A47BF04DA" modified="2022-05-25" version="1">MIFLYFQGTLTGAGDVLSQVLVEKKSANQFEWQRTVRFFAIGSFLVGPVLSRWYKVLDSRIGSGKGVIALKKVAADQGLFSPVFLGVFLTVLGAMQGNTPQHIQNDIKKNYKDILLTCWSVWPAVQICNFSFVPLHHQVLVVQTFALFWNTYLAWKTNQGLGAPSPQKELMADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MND8</accession>
    <name>A0A8J5MND8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G028130</name>
        <name evidence="2" type="ORF">Hamer_G029343</name>
        <name evidence="3" type="ORF">Hamer_G029347</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036754">
        <property type="protein sequence ID" value="KAG7157836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010002317">
        <property type="protein sequence ID" value="KAG7177459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010002317">
        <property type="protein sequence ID" value="KAG7177462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MND8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="203" mass="23280" checksum="CE2C678E04BD8711" modified="2022-05-25" version="1">MQEQRTQRRCIETKGFLEFVNQKLQITGCKTDVILRDDLYHKYKMYCKCRGLMPATIVNVGRTLAKKGVKSPSRIGGINGKGQKYGYTGIVFQPCMEVVPWHPYSAVYSMHSDSVISGKRKLEEQDQNEPKRAKITGEIIDPISTFLESFVSTSLDHKELVRQNDLFNEYREYCRQNGLEGYNNIKLGRLMTARGFKPTVRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNI5</accession>
    <name>A0A8J5MNI5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036095">
        <property type="protein sequence ID" value="KAG7157939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNI5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="123" mass="13460" checksum="CAD97B4E5D0E342E" modified="2022-05-25" version="1" fragment="single">MWPGRVLTSGRATRQGKGRRGQCGSGGLSNTRPGHPPAADLHILQTAEHLCRIPLAWARTRWRSLVTVENQLAFTCGPSPVDLHLWTFTCGPLPVDLHLWTFTCGPSLLQVIQPLNEEQVCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPQ3</accession>
    <name>A0A8J5MPQ3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Pro-resilin-like 181</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G016552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPQ3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="81" mass="9137" checksum="9F18148458D49F2A" modified="2022-05-25" version="1">MTVARPQNRPNEYYSSTGPDTPAQYNFNWQVKDDPSGNDGRLQRVTYTVNGNSGYVAEVTYEGEAQFPTYQSSYTPAPRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQF2</accession>
    <name>A0A8J5MQF2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7159920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQF2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="130" mass="14067" checksum="CE6039D7CA676304" modified="2022-05-25" version="1">MVAIQRWGRSRCWKGAKCCNQSTCAACAKRFEDGVVVGSAVTRLQKGWTTTCWIGVFGMVGGSDGGRGSGYSATEMGAKGVWCGLKGRSFVFVDMGFDEIVAWGEVALAKLPSRIMRVCDRGVWSREDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQK3</accession>
    <name>A0A8J5MQK3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ROP-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Rop-L</name>
        <name evidence="4" type="ORF">Hamer_G012656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQK3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000001">
        <property type="entry name" value="syntaxin-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7160116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="623" mass="71065" checksum="7CE4245A9B94BFA2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQV8</accession>
    <name>A0A8J5MQV8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox protein SIX6-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SIX6-L1</name>
        <name evidence="11" type="ORF">Hamer_G001763</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQV8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000046">
        <property type="entry name" value="SIX homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF33">
        <property type="entry name" value="PROTEIN OPTIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="172"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="174"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7160490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="237" mass="26362" checksum="E29222D2433F9413" modified="2022-05-25" version="1">MALMSGLGGLGSFGSFGAFSALNALSANATGTGSFGGSSSPVVPTPMVALPSLSFTAAQVAAVCETLEESGDMERLGRFLWSLPVAHPHLHDLNKHEAVLRARALVSFHVGNFRELYAILESQRYSKPSHARLQALWLEAHYQEAERLRGRPLGPVDKYRVRKKFPFPRTIWDGEQKTHCFKERTRSLLRESYLQDPYPNPSKKRELASATGLTPTQVGNWFKNRRQRDRAAAAKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRN8</accession>
    <name>A0A8J5MRN8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRN8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="103" mass="10918" checksum="391EE9C25192B4C0" modified="2022-05-25" version="1">MKDTTSTDMRILTQAAKILLQDILEKKQVFSGSFSSTSEADSVVPTLSSFLHILLDGPGIDVDIPPPPASSKKIMLSLAQIDYHAQLCGQKVTASPVCASLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRP4</accession>
    <name>A0A8J5MRP4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G028975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029054">
        <property type="protein sequence ID" value="KAG7161513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRP4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="187" mass="21585" checksum="6EBD2E00E6FBEC3B" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVREKNNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWLSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MS42</accession>
    <name>A0A8J5MS42_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G014129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MS42"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="389" mass="43493" checksum="21D7CB4E9676BDFE" modified="2022-05-25" version="1">MTSPSLYTSQSVLPSLLHITVSPSLTPTHHSETFLHSCTSQRDPPSLLHITVSPSLTPIHHIESFTHTTQHCMSFPHSYKTLQILLSLLSSPSLTHTPHYKSFPHSFTTLQVLPSLLHHTTSPSLTPTPHYKSFPHSYTTLQVLPSLLHSTTSPSLTPTPHYKSFPHSYTTLQILPSLMHHTTILSLLHNLEAFPYSYTNPCKSFLTDIQHNKSFLSSTNTTSPSITIHYTASPSSPYTTLQVLPPPYNILTSPTPLHTNLQSFPHYPQTLYVPSPPYTTLQVPLPLLHKLQVLSSLLHHTTSPFLTNTNKSSITLHNTTSPTTPTPQIVPHYYTIPTDWIGSEKMWLQARLLIQHFVGDQKYPEPKTAKLGGAGLRFQCRQNTTQVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSI7</accession>
    <name>A0A8J5MSI7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione peroxidase 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gpx8-L</name>
        <name evidence="6" type="ORF">Hamer_G007426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSI7"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035291705" evidence="5">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7161781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="201" mass="22448" checksum="47AB8F5811F18584" modified="2022-05-25" version="1">MSRIIILSVSLVLALGSCKGEDFYSYKVQDHLGNDVSLEKYRGKVTLVVNVASRCGYTEGTYQALKKLHDILSFGDYFSVLAFPCNQFGDQEPLNMPEIIEFVTNEFDVEFPVFNKIKVIGEHADPAFKRLTEESSVVPDWNFYKYLVDETGHVVAAWGTRTTIEDIIQAAVEKAKAATKSSSNQTEKSVTTDSEAVKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSU6</accession>
    <name>A0A8J5MSU6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Still life-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sif-L1</name>
        <name evidence="2" type="ORF">Hamer_G001956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7162935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSU6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003116">
        <property type="entry name" value="RBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043537">
        <property type="entry name" value="Tiam1/Tiam2/Sif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001:SF3">
        <property type="entry name" value="PROTEIN STILL LIFE, ISOFORM SIF TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001">
        <property type="entry name" value="TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02196">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00455">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50898">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RBD" evidence="1">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="155" mass="18007" checksum="6734B82F39CBF6FF" modified="2022-05-25" version="1" fragment="single">MLSRSNSVSSRRSLQMQQQLEGEKQYKVNLPDNQTVSISLKDSMSVEEFLVAACGRKNLNPMEHFVRVKKRRELEETNYFVPHRTDLIENYLATHEVVEICGKILYQVELSRSSLDHMWGFSVEAELIENSERQDELCCYISRVEDRSTAMQNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU24</accession>
    <name>A0A8J5MU24_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-phosphate phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Inositol-1(or 4)-monophosphatase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Myo-inositol monophosphatase A3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">impad1-L</name>
        <name evidence="16" type="ORF">Hamer_G004435</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU24"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008254">
        <property type="term" value="F:3'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052834">
        <property type="term" value="F:inositol monophosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000012">
        <property type="entry name" value="Blast:Putative inositol monophosphatase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF4">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7163312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="278" mass="30360" checksum="E942247E447E5156" modified="2022-05-25" version="1">MRVNMVKNILLQVYAIREAVSLHEKSKGKTKEGANDPVTDGDIQSHLTMYYSLKKAFPSLEIISEEHSVSVDTSKIPPASTHNLEVISVITDDIVVPAQDIQVWIDPLDATQEYTENLREYVTTMVCVAVKGHATIGVIHKPFSKFTAWGWAGKGGGPKDEIAHIIVSRSHAGEVESVAKAAFGDKTQVIHAGGAGYKTLAVIQGDADAYVHVTLIKKWDLCAGNAVLNALHGNMTTLSGQSIDYSSNERKKIEGRVGHAAWPQILFTKTTRPQKEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MV91</accession>
    <name>A0A8J5MV91_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CENPB DNA-binding domain containing protein 1-like 41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G003434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MV91"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7164284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="109" mass="12267" checksum="A78451E131CE7FDE" modified="2022-05-25" version="1">MSKRPAITSLTTPKTKKSRQAITLEQKNKVLEKLQRGIGASSVGCQFGLSESSVHTIKLNEKKINAAYASPDVAKGKFHLKSAMYGKMEDALKLWVEDMQWCHRHTTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWA0</accession>
    <name>A0A8J5MWA0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Interleukin enhancer-binding factor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ilf2-L</name>
        <name evidence="6" type="ORF">Hamer_G010999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWA0"/>
    <dbReference type="OrthoDB" id="5775647at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000017">
        <property type="entry name" value="Interleukin enhancer-binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006561">
        <property type="entry name" value="DZF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049402">
        <property type="entry name" value="DZF_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049401">
        <property type="entry name" value="DZF_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052134">
        <property type="entry name" value="ILF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46447">
        <property type="entry name" value="INTERLEUKIN ENHANCER-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46447:SF1">
        <property type="entry name" value="INTERLEUKIN ENHANCER-BINDING FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20965">
        <property type="entry name" value="DZF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07528">
        <property type="entry name" value="DZF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00572">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50152">
        <property type="entry name" value="25A_SYNTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51703">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZF" evidence="5">
        <location>
            <begin position="30"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="364"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7166178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="394" mass="43653" checksum="BD2FA3025FFB7382" modified="2022-05-25" version="1">MVMTRGRGRGMRGGMMRPMGPGPHFGPKMKQFVPRLPFDMVLCESAFPRVKPAPDESAFTQALLKRNADLSPTPAEQAAVLNLVTKIQAVMDNLIVDPGNFDACQIEEVRQVGSYKKGTMMTGHNVADIVVILKTLPTKEAVEALGKKVCDDLRTQEPQEVLVLTMLPNDRGFEISNSEATVRVLVTTIHQNLRKLDPELHLDQKILQSHLAAIRHSRWFEENAHHSTIKVLIRLLRDLRGRFDGFEPLSPWMLDLLAHYAILNNPSRQALPINSAFRRCLQLLAAGLFLPGSAGISDPCEGGNIRVHTAMTLEQQDLVCLTAQTLLRVLSHGGYKQILGLEGNSSIASEMSVWDGVVVSALEKAYEKPPERPPQDDDTDNMDADDDPMETTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWB7</accession>
    <name>A0A8J5MWB7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lysophospholipid acyltransferase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Mboat1-L</name>
        <name evidence="9" type="ORF">Hamer_G010541</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWB7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7166865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="490" mass="54755" checksum="0E2B0D102E472535" modified="2022-05-25" version="1">MAPDVSHHWEEFYLGSRRFQFIADNFGMPIDQVLLALLLVVGCYVLMLLLPITLIHHMSLAASLTFLSTMHIQRQIYEDGAFVIDVTGPMMIIVQKATALAYSLHDGLSGLKDEQLTPLQRELVLRKKPSALEYFSYMLNFHSVLAGPFFMFADYQDFIEGTHYAKRALDTTAATTSLDSNRNKSPTDLKTMDAQKTASRPEDEPDPTRVSLYKAGLSLICAVVTVCILPNFPISFLTQPGYFKSSYLYKGMYIVAVTSFTRHVYYTAWLVGDGICNMSGMGFNGYNKDGSAKWDLVSNVDVVGVETGLSLRDTLEAWNSGTMKWLRFMVYERAGAQKTLFTYMLSSMWHGFYPGYYITFVSGAFFTIAARYVRRSVRPRVMSHGPVVKLAYDAVTCITTRLCLAFFTFPFILLRFWSSIAVYRDIYFIPAVLGVLVIVLLPIVLPPPSRSSSSAKSSAEKLKPSVKLEDAGVNVTNGLEGGATKLLKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWE7</accession>
    <name>A0A8J5MWE7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Huntingtin-interacting protein K-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Hypk-L</name>
        <name evidence="4" type="ORF">Hamer_G005272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7166970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWE7"/>
    <dbReference type="OrthoDB" id="285219at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14361">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038922">
        <property type="entry name" value="HYPK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="3">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7166970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="116" mass="13335" checksum="1EBDFDBB747E513C" modified="2022-05-25" version="1">MSHDENHEMEDEVETKSKEKKVAKHDSGAADLERVTNYAEEKEIKSDANFMSVINDVKRQDEANKLAKEQELAKVSIKKEDVELIIRELEISKMKAERALREHQGNLIETLVTLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY07</accession>
    <name>A0A8J5MY07_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pogo transposable element-like 80</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Pogo-L80</name>
        <name evidence="2" type="ORF">Hamer_G013065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY07"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="102" mass="11893" checksum="EB83BA8F4B30F7B3" modified="2022-05-25" version="1">MDGGVKVWLDKVWFKRPGGLLRKNSLLVWDQFSAHRTENTKRLAKELNTQQAVIPGGLTSQLQLLDVSINKPFKNNTREHWNKWMTEGKYDADWKDETPINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZY1</accession>
    <name>A0A8J5MZY1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017208">
        <property type="protein sequence ID" value="KAG7169357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZY1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="405" mass="45378" checksum="9D0D9DB170662DCC" modified="2022-05-25" version="1">MTRTVCGGHYSPPYTNRGQRVEGIVRHDTLSEDSVWRSLFATIHSARTACRGSMESTRSKTEVWLIGQHITEITGAQLPSRGDVLRLFFHGHNEHKKTVNDSASEVAASVISFWNKARIPTITEKSIGRKVVDLFLMWKGLKKNCTRTTDTQRKKEETFCDELEDLFDVAHPKAMQLLTIKEDRAFLAAQREKGRRGVMAGVDKKIACSIKRREESKSKQSLQQNQASSALEYDELGSSSETESQSSSSSSTSSLAISPVVSSSNRKRATLKVITPELSSTLDRTGISHRSALRIVSATAASLGQRVEVIACHDTLSEDSVWRSLFATINYSIHHHTPTEDNMWRSLFATIHSARTACRGHCSPRYTQRGQRVEVMCSPRSPRYTRRGQRVEVIVRHDTLSEDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0C9</accession>
    <name>A0A8J5N0C9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014436">
        <property type="protein sequence ID" value="KAG7170329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0C9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="88" mass="9399" checksum="129AF4320382D681" modified="2022-05-25" version="1">MANPLTRLQDHQLSVALVPGVHGAYSCPVTASPRRRYESPQVQRDVAESSPGARVQHVPGGGAAAGAPRHHGCCLLLHHHLSMARHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0F6</accession>
    <name>A0A8J5N0F6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0F6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="722" mass="77959" checksum="CB141BFE4683D72F" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0L5</accession>
    <name>A0A8J5N0L5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0L5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="88" mass="10474" checksum="1122E400D6ADD149" modified="2022-05-25" version="1">MEKLKLEFEFKKMQLEAEREKIQADKEVELRKLEVEERTGIRRGNGDKDNKGCNLPEFVEEEAEDVFIQFEKVATIKKWDKSDWAILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0R4</accession>
    <name>A0A8J5N0R4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Methionine synthase</fullName>
            <ecNumber evidence="15">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">MTR-L</name>
        <name evidence="25" type="ORF">Hamer_G013933</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15 16">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="15"/>
    <dbReference type="EMBL" id="JAHLQT010012946">
        <property type="protein sequence ID" value="KAG7171128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0R4"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02069">
        <property type="entry name" value="methionine_synthase_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00740">
        <property type="entry name" value="MeTr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1240.10:FF:000001">
        <property type="entry name" value="Methionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000002">
        <property type="entry name" value="Methionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000001">
        <property type="entry name" value="Methionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.280:FF:000001">
        <property type="entry name" value="Methionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.280">
        <property type="entry name" value="Cobalamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.288.10">
        <property type="entry name" value="Cobalamin-dependent Methionine Synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="entry name" value="Methionine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="entry name" value="Vitamin B12-dependent methionine synthase, activation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050554">
        <property type="entry name" value="Met_Synthase/Corrinoid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033706">
        <property type="entry name" value="Met_synthase_B12-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011822">
        <property type="entry name" value="MetH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02082">
        <property type="entry name" value="metH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007024">
        <property type="entry name" value="PRK09490.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45833">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45833:SF1">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000381">
        <property type="entry name" value="MetH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="Cobalamin (vitamin B12)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="Methionine synthase activation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="Methionine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 15 16" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="14 15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 15" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 15 19" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 15 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 15 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 15 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="20">
        <location>
            <begin position="14"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="21">
        <location>
            <begin position="367"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="24">
        <location>
            <begin position="658"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="23">
        <location>
            <begin position="769"/>
            <end position="904"/>
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        <location>
            <begin position="934"/>
            <end position="1251"/>
        </location>
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    <feature type="binding site" evidence="16">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="705"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="779"/>
            <end position="783"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="782"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="827"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
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    <feature type="binding site" evidence="17">
        <location>
            <position position="831"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="883"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
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    <feature type="binding site" evidence="17">
        <location>
            <position position="985"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
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    <feature type="binding site" evidence="17">
        <location>
            <position position="1179"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001956"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005178"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7171128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1251" mass="139504" checksum="CE688EFDA6E13523" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">Hamer_G021679</name>
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        <name type="scientific">Homarus americanus</name>
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            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="60"/>
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            <end position="42"/>
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            <end position="53"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7171199.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        </source>
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        <source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N292</accession>
    <name>A0A8J5N292_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Hamer_G000885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="66" mass="7267" checksum="8A53596D5FC8601C" modified="2022-05-25" version="1">MEGQGGREAREDERPRKMGDGRPGGRGWPERMGGQGEWEAKKSGRPPALRRLLGSVKAALYGHVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3A3</accession>
    <name>A0A8J5N3A3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Leucine zipper transcription factor-like protein 1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">LZTFL1-L1</name>
        <name evidence="1" type="ORF">Hamer_G027352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011148">
        <property type="protein sequence ID" value="KAG7172431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3A3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026157">
        <property type="entry name" value="LZTFL1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15294">
        <property type="entry name" value="Leu_zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="170" mass="19515" checksum="E82687BEC3C73172" modified="2022-05-25" version="1">MTWVTWGLTEDHQACMAGTSASPSIKKLKGSAPSSLLPGCQGYQMSSRRRWKRTDPHYAHQLPLLNFAQAQKWHQSQRRHLRPGEPLVDEVENMRLQLTTQAEIKNASQDQLAIDPNASRQTLLQELEKKFTDGAYQNMKKMLNKKNEQIKVMRKKLVAYEPDNGEVIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3K1</accession>
    <name>A0A8J5N3K1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G030455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010646">
        <property type="protein sequence ID" value="KAG7172538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3K1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="570" mass="65399" checksum="E7CEE47494C88E7F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3V1</accession>
    <name>A0A8J5N3V1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Elov-L4</name>
        <name evidence="12" type="ORF">Hamer_G006824</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3V1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7172614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="365" mass="41126" checksum="D0BB0DD8105D7910" modified="2022-05-25" version="1">MTSSESDTRPSPQQGGKDLEALKINGRWAAGITILCFMYGEITVASQLPVDPRQGSWLLLQSPLPSLLLCLLYVGIVTWWGPLYMSSRKPFSGLRPFMIAYNAFQVVFSAWLLFEGGRNGWFGSYKFICQTCDFSNNPKAIGIFFVLNKKYEHISVLHVSHHALMPISLWYGVRHQAGGHATFMGFINSFVHVVMYSYYLLAAMGPRLRPYLWWKKYLTMLQMVQFTIVFFHAVSVAFVECEVPSVCLRWECGIAVMFFVLFANFYIKSYRKSVKIEGNAGTKVTMPGLSNMCYIHPSSKHSYKMAYDASRVMTNGFPNGKPNNVSNGKLNGVTKEIPNSMVIGASDDASPHRQEAVRLRSPVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4Q7</accession>
    <name>A0A8J5N4Q7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative wiskott-Aldrich syndrome protein family member 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Wasf2-L</name>
        <name evidence="6" type="ORF">Hamer_G014553</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010116">
        <property type="protein sequence ID" value="KAG7173232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4Q7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7173232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="86" mass="9665" checksum="651E9104C15897FC" modified="2022-05-25" version="1">MSCPVCMKPYNTTHQEPMMTPCNHSLCLTCLIDLVTYTHPDTQVQGHQGQDQPAMEQGPPHLPKGKVVLCPYCKEQVNTDQLITNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7A4</accession>
    <name>A0A8J5N7A4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cation channel sperm-associated protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7175041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7A4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="631" mass="68736" checksum="ED7357EDF4C10358" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7Y0</accession>
    <name>A0A8J5N7Y0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Jagunal-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">jagn-L</name>
        <name evidence="8" type="ORF">Hamer_G001538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the jagunal family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7Y0"/>
    <dbReference type="OrthoDB" id="8914197at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009787">
        <property type="entry name" value="Jagunal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20955">
        <property type="entry name" value="PROTEIN JAGUNAL HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20955:SF1">
        <property type="entry name" value="PROTEIN JAGUNAL HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07086">
        <property type="entry name" value="Jagunal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7175445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="192" mass="22122" checksum="C46874E54A4E8FA2" modified="2022-05-25" version="1">MASRDGPVVSGTDGSDFVHRETVAAHYQISALNKGRLRKCVFAHLLLALLMLVKMVPDFLDRFDIFILEIEELEVPQPLKWEYIWLVGSLASFLGLIAIRKNRVLLLQIYFGLINLLSTVPILLAAMIYFKDFWKYCTEEEPEGLQLWLGYPVSVLWYSFIMVAMQVHIFTLIFAWKLILAWKNRGAAKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8M2</accession>
    <name>A0A8J5N8M2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G022392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006025">
        <property type="protein sequence ID" value="KAG7175465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8M2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="166" mass="17693" checksum="06A09E616B5606C1" modified="2022-05-25" version="1">MRVMMKREGMMMGEENDESDVTLCFVLVGGQQEERKEGRKEGRREGGKERGREASHGYIKEERNSRSATLHPPVVAATTPDCSAPPLLHIMTKFLLVVVVALMVLGMVQAVPGGSHGYGGYSGGYYPGPRYNGGYTGGFGGAYTGFGHGTGGGGTAGYNSKLQIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N902</accession>
    <name>A0A8J5N902_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DnaJ subfamily A member 1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Dnaja1-L1</name>
        <name evidence="14" type="ORF">Hamer_G001375</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N902"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000014">
        <property type="entry name" value="dnaJ homolog subfamily A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000005">
        <property type="entry name" value="DnaJ homolog subfamily A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="13">
        <location>
            <begin position="122"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="10">
        <location>
            <begin position="122"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7175317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="398" mass="44812" checksum="4B679BEFC5AA6DA6" modified="2022-05-25" version="1">MVKETGYYDVLGVKPTATSDELKKAYRKLALKYHPDKNPNEGEKFKHISQAYEVLSNEEKRKIYDQGGEQALKEGGTGGGNFTSPMDIFDMFFGGGMRRGREKKVKDVIHQMNVTLEELYNGAVRKLALQKHVICSKCEGQGGKKPPEKCPSCRGTGMQVRIQQLGPGMVSQVQSMCGECRGQGERISPKDRCKTCEGKKVVKDRKILEVHVDKGMEDGQKVVFSGEGDQEPGLEPGDIIIVLDEKEHPVFSRRANNDLTMQMHISLVEALCGFQKQIKTLDDRTIVISTIPGEVIKNAEVKAVLGEGMPQYKNPFEKGRLLIQFLVDFPPHIPLDRISRLEKILPNRPGVMIPDESEECQLIEMDRSQRSRRHNHSLYDEDDDDHHGGRQHVQCQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA86</accession>
    <name>A0A8J5NA86_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450 9e2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Cyp9E2-L</name>
        <name evidence="15" type="ORF">Hamer_G025073</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004517">
        <property type="protein sequence ID" value="KAG7175942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA86"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF102">
        <property type="entry name" value="CYTOCHROME P450 FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7175942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="315" mass="35860" checksum="997F67D4DB6F4093" modified="2022-05-25" version="1">MPPSGGEAFARKSGRCPHLCRRRGEALPPIRAHHTLGMYRRSGHPLELRRTPQSRAGHLLELGMQKIKRWCEVTDTNQEAKKKLKQEKSLERLRTAKTIIAQSVLFLLAGYDTVSSTLSFITFLLAKNPIHQQRVRREVQELVQLHGELTYQVILDSKFLEACIMEALRLYPPAPNIERRCTKTYRLPGTDLTVRVGDMVVIPIWSLHHDARYWPDPELFLPDRFLPENKSSITTATYLPFGLGPRICIANRFAMMETKITLAKLLLAAELSLPEGQEHMELATSLILMRPRHSVNIILTTLTHSPDSPLTTLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBG5</accession>
    <name>A0A8J5NBG5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abscission/NoCut checkpoint regulator-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Zfyve19-L</name>
        <name evidence="2" type="ORF">Hamer_G021267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003531">
        <property type="protein sequence ID" value="KAG7176438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBG5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009838">
        <property type="term" value="P:abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044878">
        <property type="term" value="P:mitotic cytokinesis checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603">
        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="312" mass="33733" checksum="326D3CE33B575697" modified="2022-05-25" version="1">MSDQDRNPLKKQLSKSSLEKSLQMISPPQQAPVTIYPGPSAGMANLSKADLEIAQRLQNLRKSQSDNVPTEEEMASRLAHLKGLPADHYAKTSTVAYQPPDARTQGQRTDDLLSQVMEEVSLDSRVPNQDDELEARLARLRGEESRPSQPQGAMALPSAAYLANSQAAEKEAQASAEKSVGELQADPELAGAVAQATRKKEKKGRQKKSKGTSGGSSDEERHSKSFDSDLEIEGGKAIDAVTEQEEVQRIIDMYTKRAQLKKEKKKKKKEAAAAAMGGAVGGDDSDSDIEVSSVSDLSSDSEKFSMSDELSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBM8</accession>
    <name>A0A8J5NBM8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor SOX-4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Sox4-L</name>
        <name evidence="7" type="ORF">Hamer_G021121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001894">
        <property type="protein sequence ID" value="KAG7177771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBM8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22029">
        <property type="entry name" value="HMG-box_SoxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000007">
        <property type="entry name" value="Transcription factor SOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF323">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="256"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="256"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="477"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7177771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="628" mass="69445" checksum="6C7D77AC4D6DCA69" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NF47</accession>
    <name>A0A8J5NF47_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proton channel OtopLc-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">OtopLc-L2</name>
        <name evidence="2" type="ORF">Hamer_G008440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NF47"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="93" mass="10515" checksum="30F32067311A7FC2" modified="2022-05-25" version="1">MANSDDDNSSANLSFKLRRGSSDSRESFYMDFDRGIDSDIEEVSSKPRTSTFVSSVEKKTLECASEDEALIELRERNFLVKRSADDYVHCSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NGP0</accession>
    <name>A0A8J5NGP0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">inx2-L3</name>
        <name evidence="12" type="synonym">inx</name>
        <name evidence="13" type="ORF">Hamer_G003998</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NGP0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF41">
        <property type="entry name" value="INNEXIN INX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7178198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="247" mass="29059" checksum="C921E5FF4E6FAF2E" modified="2022-05-25" version="1">MLIVPFFQAIMFYIPRYLWKIWEGGKVKMLVMQLNSPILDDDVKRERKAMLVDYFSVNLHNHNFYAFRFFLCELLNFINVIGQIYFTDRFLGYEFTTYGTRVIEFSEQEFGSRHDPMDEVFPKVAKCTFHKYGASGTIERHDGLCVLPLNIFNEKIYIFLWFWFIIVAVISGVGLLYRLATFTPAFRQILLRTRSRLASSDNVEAISRKCQIGDWFVLYQLAKNMDPLIYKEFITDLANKLQGKGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TCH9</accession>
    <name>A0A8J5TCH9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F-box only protein 30-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Fbxo30-L</name>
        <name evidence="6" type="ORF">Hamer_G015779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007499">
        <property type="protein sequence ID" value="KAG7174644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TCH9"/>
    <dbReference type="OrthoDB" id="5918172at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031890">
        <property type="entry name" value="Fbxo30/Fbxo40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933:SF20">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933">
        <property type="entry name" value="PROTEIN CBG16327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15966">
        <property type="entry name" value="F-box_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15965">
        <property type="entry name" value="zf-TRAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="557"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7174644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="685" mass="78428" checksum="4BBB18EB7496D6C3" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TCJ3</accession>
    <name>A0A8J5TCJ3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TCJ3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="84" mass="8783" checksum="0011DAD63594E23A" modified="2022-05-25" version="1">MSTTAVLTAALGLDSCQDCLTAALGLLTVDMGLRTTAVLTAALGLLTRSWDAHNSSAHSCPGTADSCCYWDCAQQQCSQLPWDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TEX2</accession>
    <name>A0A8J5TEX2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Relaxin receptor 2-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Rxfp2-L4</name>
        <name evidence="10" type="ORF">Hamer_G026884</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006599">
        <property type="protein sequence ID" value="KAG7174854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TEX2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF80">
        <property type="entry name" value="FI21465P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7174854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="174" mass="19791" checksum="26538EDDA85577E8" modified="2022-05-25" version="1">MTSWQCTLTGVLAMTSAEVSVLILSFMSVERWVCITWPLRHKLSLEGQGRPHLHLGTQLPFGRHPSSLLPRAAEVLWYNGLCFRCIWTTLGARLFYSALIFVGLNQIGVVLILMSYTGMFCSIRRTRANTPLSWAIESSPCFFFIVFTDCLCWTPIIILRIMALADIPITRQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIB1</accession>
    <name>A0A8J5TIB1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyl hydrolase family 63 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G006818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIB1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="3">
        <location>
            <begin position="507"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="2">
        <location>
            <begin position="636"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7172608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="975" mass="110675" checksum="E50C53DB6C941230" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJ38</accession>
    <name>A0A8J5TJ38_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Solute carrier family 35 member F5-like 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005627">
        <property type="protein sequence ID" value="KAG7175545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJ38"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="217" mass="24906" checksum="0DE027277C2B5F38" modified="2022-05-25" version="1" fragment="single">SAPGEEIGNEFTGFRVSSQNQIVRELLSYAQDLGNPTAKEAASRLDADNINEWMGVDDDESTVHHYTDVEIVQMVYIFNDTGFNKPFFSTYLKTSMFSLYLLGFIFWSPWRHQCAQRNHDESIYQTRDRRTPPPVPIFTLDQLASSVARDSDANAQLTHLVLWHYLPIQQARTIYNNNDEKSEPKYVPLKLQELQEKSSDGESDDSSVKSVRFSKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKT2</accession>
    <name>A0A8J5TKT2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="17">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Polr2a-L1</name>
        <name evidence="20" type="ORF">Hamer_G000431</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="17"/>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.140:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 17 20" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="14 17" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="19">
        <location>
            <begin position="237"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1529"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1582"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1532"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1552"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1582"/>
            <end position="1898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG7177181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1916" mass="211803" checksum="3BBDADD482906848" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TL18</accession>
    <name>A0A8J5TL18_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TL18"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="105" mass="11607" checksum="159A2600B92D2B2D" modified="2022-05-25" version="1">MRTIELHHKLRKDGVCRSIISNVGLEQDISWSGRVSSGSDCHADHVDFAFAIKRRCSIATNSSQKKHFVAEESLPSVDVTWDSCVTQTLPELICRVLVGLPPSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TL90</accession>
    <name>A0A8J5TL90_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Optineurin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Optn-L</name>
        <name evidence="6" type="ORF">Hamer_G003396</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TL90"/>
    <dbReference type="OrthoDB" id="6380147at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032419">
        <property type="entry name" value="CC2-LZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051301">
        <property type="entry name" value="Optineurin/NFkB_EssMod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31553">
        <property type="entry name" value="NF-KAPPA-B ESSENTIAL MODULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31553:SF1">
        <property type="entry name" value="NF-KAPPA-B ESSENTIAL MODULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16516">
        <property type="entry name" value="CC2-LZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="578"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="222"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="474"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7174452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="604" mass="68584" checksum="A2F56D395F1B9E11" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLL3</accession>
    <name>A0A8J5TLL3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006389">
        <property type="protein sequence ID" value="KAG7174903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLL3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="50" mass="5423" checksum="F320BF7F135A0E33" modified="2022-05-25" version="1">MHLQDSPSFRTLPPLQPALQHLTVLPYATGDSTLTPSSTPAPLLLPSDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TVN8</accession>
    <name>A0A8J5TVN8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Msantd-L15</name>
        <name evidence="6" type="ORF">Hamer_G027856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000974">
        <property type="protein sequence ID" value="KAG7177933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TVN8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="5">
        <location>
            <begin position="15"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7177933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="294" mass="32671" checksum="67B8B347D943A77B" modified="2022-05-25" version="1">MFARGLSNMEVVRERSAALSETQRMALLRHIEQRPIIEDRSTSITINYRKRKAWDEITASFNASYPDQIPRSAKQLKRIFAEVLEQPSARGMRKTSASVPSASLTQSYDPLVLPGLTPGPSSVSSAQFTEVPSTVYLPLFSPSVPVSQVIVPASPVIAPASPNIAPASAVNAPDSLSSDIASPPPAHASNQHLYSVSRASGSRPRSKPRRTRRVTSVYEMCDKRQEELHKSKLYRLNREHEEEMKLKKEMMLTQKLQQTAIEKTHEKLNNSLDLLDSVLRKAGAAYDAMAKTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J7U5</accession>
    <name>A0A8J5J7U5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposable element Tc1 transposase-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tc1a-L6</name>
        <name evidence="4" type="ORF">Hamer_G009506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J7U5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF134">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC1 TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="3">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7153811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="173" mass="19876" checksum="5196D8F3F0DDFA0D" modified="2022-05-25" version="1">MPGTNITREEKVRILTLIEEKVPVNEIVRRTGRNKATIHRLKAVACELPPASVPPAKPRSGRPRKTSKTTDALLRREVLKTPHITAAELQRNHPDVLGNVAPRIIQHRLQKELHLPRRRPAKKPLLTDKMGKARLGFARKYRHWTPQQWAKVIWSDESTVQCVKMSGNRVRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JAZ2</accession>
    <name>A0A8J5JAZ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045864">
        <property type="protein sequence ID" value="KAG7153978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JAZ2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="416" mass="46164" checksum="3D64B157E2D4F7EE" modified="2022-05-25" version="1" fragment="single">GNESLNPKERESLGEEKRSNDGPSHNTSPDTHNIQVSTNTPVSNTPVSNNSVSNTPVSNTPVSNNSVSNTPVSNISVSNTPISLTPVSSQHRSTPEVPVLLTRRSRLVNGYTKTSKDKRQTRNRGNRENEERIEENIRRERDRKSTDSGLGRTSSEGVNSPFSEEPTRMKGWERSSAESEGWKDTTEGHRRREKGNKGVKAVGGTKAAKKDEMTRLEKELEQEMRYRNDLKILVRGMMKEYHHLKELIRAYTGDLTIVNRSLEHLWRQQSVSYDSHFAGGASPVTSPGGVKWSSGQAGIRPSQRILDPRKGPIRKTVGVRSLPRLDQEALDYYDTGSLFRKARSRSRGRPRGRAKSLDAKKEISAPNVVPPLSPVSRTKSEEVQSQRSSSGVFDESCEASNDASTTASAELNSDKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JBB5</accession>
    <name>A0A8J5JBB5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione hydrolase 1 proenzyme-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GGT1-L</name>
        <name evidence="3" type="ORF">Hamer_G020478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045000">
        <property type="protein sequence ID" value="KAG7154169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JBB5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="582" mass="62566" checksum="DF54E4AD91B7214A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDG7</accession>
    <name>A0A8J5JDG7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PiggyBac transposable element-derived protein 4-like 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PGBD4-L23</name>
        <name evidence="2" type="ORF">Hamer_G006178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDG7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="101" mass="11249" checksum="1FF1F7746D94F3C4" modified="2022-05-25" version="1">MTFVGTIKANKKEVPKEMTDRDNLRLGSTAFLFTKELTLVSYVPTTAKTMKKLVLLLSSMHTQPTIGNTGKPEVIEFYNATKGGVDTFDHFYPVCANCMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDS3</accession>
    <name>A0A8J5JDS3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Pyrimidine nucleoside phosphorylase C-terminal domain-containing protein 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Putative Pyrimidine nucleoside phosphorylase C-terminal domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G015044</name>
        <name evidence="4" type="ORF">Hamer_G020983</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010043055">
        <property type="protein sequence ID" value="KAG7155120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDS3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="entry name" value="Pyrimidine nucleoside phosphorylase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="Pyrimidine nucleoside phosphorylase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyrimidine nucleoside phosphorylase C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7155120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="86" mass="9211" checksum="1390084DA0E88EE0" modified="2022-05-25" version="1">MDAMALAKVSLALGAGRNRVGEPINYAVGIVLHKVVGESVKEGKLGRSCTTTDHYLRLSLPTPRLLSLSTPMPHFEEVSLIAARVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEL5</accession>
    <name>A0A8J5JEL5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G024621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042957">
        <property type="protein sequence ID" value="KAG7155156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEL5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="148" mass="16484" checksum="203315A395886110" modified="2022-05-25" version="1">MECISEVTTAFLSLASTPSELPDDVLSTLERFIVLLCDRTSTCCDVNVLRKKLFSRKSRSLEHLPPTRAALEQYIKRAAYQAGHIWGQAAIAFVILPSPCDWGWMKSGDELEPLWTTLSDVSKSSHELICCGCRKHCGGKCRCKKSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGD1</accession>
    <name>A0A8J5JGD1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036987">
        <property type="protein sequence ID" value="KAG7157692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGD1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="132" mass="14462" checksum="BE45BB5F0A14DDFC" modified="2022-05-25" version="1" fragment="single">MLQQYFEKFNCTITAENDQVEPGTRGATTNTAPSPPMPRKSRTFHYIYAAVQVSFHQNPTIKRVTYQLESTASDPLSPTPLGWGSEVCSGNYLALGALCFWAYDSDISGLGGPQGCAESWDKESWGQEASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHI0</accession>
    <name>A0A8J5JHI0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative early nodulin-75-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044465">
        <property type="protein sequence ID" value="KAG7154408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHI0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="499" mass="57886" checksum="6F8A8817B41FAA01" modified="2022-05-25" version="1">MMSLSTNMCHRPSHFTVNQNTSLYRQPDLPHFYCQPGLPHFYRQPEHLTLPSTRPSHFTVNQTFLTLPSTRPSSLYRQPEHHFTVNQNTLTYRQPDLPHFTNQTFLTLLSTRTPHFTVNQNTLTLLSTRPSSLLPSTRPSSLYRQPELPHFTVNQNTSLTVNQTFSLARQPDSHFTVNQTFLTLPSTRPSSLYRQPDLPHFTVNQDLPHFTVNQTFLTLPSTRPSSLYRQPDLPSLYRQPDLHFYRQPDLPHFTVNQNTSHFTVNQNTLTLPSTRTPHLPSTRPSHFTVNQTFLTLPSPDLPHFYRQPDLPHFTVNQTFLNFTVNQTFLTLPSSTRPSSLYCQPDSHFTVNQTFLTLPSRPSHFTVNQTFLTLPSTRTLSLYRQPDLPHFYRQPDLLTLPSTRPSSLYRQPEHPHFTVNQTFLTLPSTRPSHFTVNQTFLTLLVNQTFLTLPSTRPFLTFQSTRPSHFIRQPGLISYPVHKSLYQRDSLLKVIKVNMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHY1</accession>
    <name>A0A8J5JHY1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G012079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHY1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="75" mass="8840" checksum="8951BCD598703AEA" modified="2022-05-25" version="1">MTQQQVMQAVSNVEELKDALMSVEPSLQHSDELSAQLDNLVEPYGQRYQEFIKRHRQTLSLPILCLNNSRRIQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJX5</accession>
    <name>A0A8J5JJX5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Chst8-L2</name>
        <name evidence="11" type="ORF">Hamer_G005706</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJX5"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7157304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="435" mass="50570" checksum="E433EE68F4B0D772" modified="2022-05-25" version="1">MRVKEGKSAGGWGGLSERGRNIIMYYANSKTLRVLAFTILAGAFFVYYHHYTVGSLPQNTSTQIQINDSGRITSVGLSLNEVQTFLLKQIPKSAEGERQELKEAQKNAGVETQAGGESEMSSDYMFEDKCCKKEKGVTWRHPVMQPSHGSFLKNLNFSNYTQKDREFLQDHTKIMIKRTDLITKMCKSRPQLATSRPLHLLWYTNHDPNIILCPIYRASLTPQMMELFNKIHVTEVDPSERTRVFTSGLRVLVVRDPLIRILYIYLDKIATRKPCSDYFEKLQKMIVARYRKKKKKQKLPRYPAFHEFVQYVLDSTRSLHSAEDWMTKAECWTPYWAQCNVCAADYDIVLTAETLEKDEKFLASVTNMKTYKDQHSSKSLQSTDNNKILSQSDIKDYLRQLDVQQMNLLYQHYILDNEIFAYKSTKKKHLYLAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLG8</accession>
    <name>A0A8J5JLG8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLG8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="107" mass="11645" checksum="8BBDAC7A57DB4C6D" modified="2022-05-25" version="1">MNDISDDAKSDSGDDTDSGDESQLEIITEEPDDILSGAEVDGQDDSAPIGRLSNSPVSRERFPFTGDTGVKVVLQDPQNPIEICLSFVDRYNGTYSERDKQICCQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JM16</accession>
    <name>A0A8J5JM16_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G021052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034856">
        <property type="protein sequence ID" value="KAG7158501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JM16"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="97" mass="9467" checksum="837A836325DEEBD2" modified="2022-05-25" version="1">MQIPGWWRCWECGGGSVLVEVLGDGGGVRECGGGVRCWCWGDGERSGDGGGGGGVSGGGVSSDEVGVKGRVLVESVGLTGVLVGVVVNGDGDSGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ20</accession>
    <name>A0A8J5JQ20_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G030349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031598">
        <property type="protein sequence ID" value="KAG7160233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQ20"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="230" mass="26271" checksum="248CDB02B04CD1EC" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPMINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAESQGSMQMGSIDYSETKKQIANAKKREQIREREQNEEKVPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRB5</accession>
    <name>A0A8J5JRB5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Guanylate cyclase</fullName>
            <ecNumber evidence="3 12">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Gucy2f-L</name>
        <name evidence="16" type="ORF">Hamer_G021663</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 12"/>
    <dbReference type="EMBL" id="JAHLQT010031456">
        <property type="protein sequence ID" value="KAG7160285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF462">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="547"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="15">
        <location>
            <begin position="859"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="238"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1125"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1171"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1209"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1284"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1176"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1216"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7160285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1396" mass="155663" checksum="E9AC8E214E61E248" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSC9</accession>
    <name>A0A8J5JSC9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TWiK family of potassium channels protein 18-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">twk-18-L1</name>
        <name evidence="10" type="ORF">Hamer_G004590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSC9"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF87">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
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            <begin position="2501"/>
            <end position="2530"/>
        </location>
    </feature>
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            <begin position="2597"/>
            <end position="2615"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2624"/>
            <end position="2637"/>
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            <begin position="2819"/>
            <end position="2857"/>
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            <begin position="3012"/>
            <end position="3027"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="3029"/>
            <end position="3042"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3166"/>
            <end position="3178"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="3186"/>
            <end position="3195"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3955"/>
            <end position="4007"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4064"/>
            <end position="4087"/>
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        <location>
            <begin position="4088"/>
            <end position="4133"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4134"/>
            <end position="4153"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4161"/>
            <end position="4176"/>
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        <location>
            <begin position="4449"/>
            <end position="4472"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4639"/>
            <end position="4660"/>
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        <location>
            <begin position="4661"/>
            <end position="4675"/>
        </location>
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        <location>
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            <end position="4706"/>
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            <begin position="5019"/>
            <end position="5034"/>
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            <begin position="6076"/>
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    </feature>
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        <location>
            <begin position="6239"/>
            <end position="6295"/>
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    </feature>
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        <location>
            <begin position="6322"/>
            <end position="6331"/>
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    </feature>
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        <location>
            <begin position="6339"/>
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        <location>
            <begin position="6433"/>
            <end position="6512"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="6512" mass="710518" checksum="A778CE66CC32F4A8" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXA6</accession>
    <name>A0A8J5JXA6_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G032176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
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            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026784">
        <property type="protein sequence ID" value="KAG7162883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="20" mass="2587" checksum="C7C1D6516659FBC6" modified="2022-05-25" version="1" fragment="single">MAKRRRKRRKQEEEEDGQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5JXW3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Interferon regulatory factor 2-binding protein 2-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">irf2bp2b-L</name>
        <name evidence="5" type="ORF">Hamer_G005628</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022531">
        <property type="protein sequence ID" value="KAG7166515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXW3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022750">
        <property type="entry name" value="IRF-2BP1_2-like_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816:SF19">
        <property type="entry name" value="PROTEIN INTERACTING WITH TTK69 AND SIN3A, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11261">
        <property type="entry name" value="IRF-2BP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon regulatory factor 2-binding protein 1/2-like zinc finger" evidence="4">
        <location>
            <begin position="15"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="310"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7166515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="423" mass="45953" checksum="72E8CC08FC7D908C" modified="2022-05-25" version="1" fragment="single">MLSESRGAMSSYRSQRQHCYLCDLPRMPWAMLHDFSEPVCRGCVNYEGADRIDLVIEAARQMKRAHGINENRQGPAKPHPRVPMEAQNGAHHGPIKLEGGIKMEPGSHSQSGSHSHAHSHGHPAPLPPPGAPGVAFVSGDVRQRGPHMLAFPAGLAHREDPHAPSLVRPPAHLTAHPPLPPPHSRPPGAPGSSSGSAPQKRSFERDDAQSPSEGSVPKRPMLEEGHRPTLTRGESLPAAPVAPNYKDSAKHHPVRVWSFDGSSKPPSGNEIAAHFRLSLLGLGAGALRSGAAVGGTKLKASGSVVSAGLQRGPQPSSSSSGGPRSSPFSQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQKKKEDEQPSGRWSASHLGTYLTYHINTRSGLRSAHGRISVFLGLMTFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYJ1</accession>
    <name>A0A8J5JYJ1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Rnf2-a-L</name>
        <name evidence="17" type="ORF">Hamer_G014398</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010026055">
        <property type="protein sequence ID" value="KAG7163949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYJ1"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16740">
        <property type="entry name" value="RING-HC_RING2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000100">
        <property type="entry name" value="E3 ubiquitin-protein ligase RING2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043540">
        <property type="entry name" value="RING1/RING2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1 / RING 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="148"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7163949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="315" mass="34876" checksum="DB49A1325B74D6EA" modified="2022-05-25" version="1">MTTTEQNAVNKSWELSLYELHRTPQEAITDNTEIAVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCQECIITALRSGNKECPTCRKKLVSKRSLRPDPNFDTLISKIYPSRDEYEQHQERVFAKLNKNHNHASLITSIEEGIKLQFQSRQKNRKAMQDEGTTPTPTPSAPSTPTPSEPPSTPTTTHTSGANTTTPTNAPTPTNVTTPTNAASSTIGPKMKKPRRTSENESGAGSSNDGNPGEEAEGPSESGEIELVFRPHPLEMNEDNELIRELKDSSIRYIKTTANATRFSFALNMTLKMSTPPAYGAKILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZ91</accession>
    <name>A0A8J5JZ91_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative winged helix-turn-helix domain containing protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G010346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZ91"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="91" mass="10172" checksum="123EB99AFDB40410" modified="2022-05-25" version="1">MSRRVTTRDDIAAVIALYKANHVLREISAQTGVALRVVQNLVKRFRDLGEDELPAPLPKSGRPKLLSPRTLKVISRQVRSSPSLTAREVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K098</accession>
    <name>A0A8J5K098_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G010151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K098"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="273" mass="30073" checksum="3ABA1FF34582DF5B" modified="2022-05-25" version="1">MLVRKPLGAVSNNFPYKKITGDVVLTGTVAVTVQDRSRVVCGAACTVTPGCKAFSYVFEDPKYSCSIFTDVTTVDYNTGPSNQAYAMESFLGTLYNSLLETTSYALNNNNNLLVKCNANYALGAIINGRKIQDKTDILNAICLKFNGPEFLLSGSVVNVPTGIQSTSKMCPTNHVMISFEGKTSTGTYTWNVPETLEGMCMKLDGWMVKEDMCTNLAHTEGFWNGLNYPTDNEAHWKVFFNCPINYVIVQLTRELVNGNKLINMVRCCPVIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0K4</accession>
    <name>A0A8J5K0K4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Complement factor H-related protein 4-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Cfhr4-L2</name>
        <name evidence="7" type="ORF">Hamer_G011873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7165956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0K4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051503">
        <property type="entry name" value="ComplSys_Reg/VirEntry_Med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45785">
        <property type="entry name" value="COMPLEMENT FACTOR H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45785:SF2">
        <property type="entry name" value="COMPLEMENT FACTOR H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="123"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7165956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="306" mass="33397" checksum="358CC51BD3F9A9D6" modified="2022-05-25" version="1" fragment="single">MTRTWTGDTAVSTTAQYTCSRGYFVEGTEGNTSQSLMCTGQLGQWLPLLLPCLEFPVCLLKNITVPQHINVTQEAKSQYINGTVNYTCPELMTTMAGDTVQTLTCLYTRRRYAFVPGVVSPCDVCSEEPMAENAVADWKPSITWTVHMTVMFTCTAGYSTGVNTNTGVFTCTNTGWTTPDACYEGCAGEPIVANASTAWSNTVIWKEGMTLVFTCVDGYITDPDNTTGVLTCNTTGWTTRDECYEACAQEPTIANATTVWVNTETWTEGMTVLFTCIESFLTDAGSNTGVINCSLTGWRTDDVCYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0L7</accession>
    <name>A0A8J5K0L7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021832">
        <property type="protein sequence ID" value="KAG7167161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0L7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="347" mass="38626" checksum="7D077EB9FB8D76CD" modified="2022-05-25" version="1">MSYPSPLHVPEENSIDLRSSEISELYHQSILPLCNQVQRLTNQMEQWVSSPTKCVKMETGVSQSEQRGEPMHKEDSVDIFHQVVAHEMKLRTFSGTPDNSDQINVGEWIAEAKCNIRLLGYKGRGESAIYVDSGGTGRPPVGTGTKVEGEEVHQGGPLSSQEMESRPRECRKLLERREMANPCCGKPTSRGRKSGLVTQRVAGVGLHSPEGLVLKAANGGSIPYLGYMLVDVEILEYKIEQCFQEIESIHRWQQKDHVGFASSTRWKPTRIPANCRQAVSIYIRSLRRCPKLEVLIEPMQAGGEDNETPCPAEEGADSPQVTGQLMWLPSISQEGLEQLQEQDSNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0U4</accession>
    <name>A0A8J5K0U4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GRIP and coiled-coil domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Gcc1-L</name>
        <name evidence="9" type="ORF">Hamer_G017191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0U4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.60">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF25">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="8">
        <location>
            <begin position="564"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="129"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="385"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="511"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7167281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="632" mass="71950" checksum="B1BC6E54D59471B1" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3H3</accession>
    <name>A0A8J5K3H3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zwei Ig domain protein zig-8-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">zig-8-L7</name>
        <name evidence="3" type="ORF">Hamer_G012916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3H3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001061">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF45">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 12, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="110"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="221"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7167456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="342" mass="39402" checksum="2B05EC383857ED6D" modified="2022-05-25" version="1">MEEEREGKKRRSRSEKKKKKRGRTIRGRKKRKGERRGTEEETMGRLTARKMCYRMLGEKARSVSVERVWWWVYGRPLGRWAYLMLLLMLHSHPPHTAAQYTDTMNDSRLPRAHRTWVGVENNTMVNVKAQLGYKAFLPCSVRMIGDKQISWIRRRDWHVLTSGVFTYTTDERFSITHRDGADDWTLSIKFLQARDNGTYECQISTGTGIVSQFVNLNVIVPEAFILGNSEYHVETGSPINLFCIIEQTHIPPHVVYWKHNGRLLNYDSERGGVSVTTEHGTKTSSRLATRQQRSSEEHQGVWARCGCMGGRGWASSPFSHCSGGHPQPTYSYSATNTHYFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3P9</accession>
    <name>A0A8J5K3P9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">High-affinity choline transporter 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Sc5a7-L2</name>
        <name evidence="15" type="ORF">Hamer_G020952</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017704">
        <property type="protein sequence ID" value="KAG7169260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3P9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005307">
        <property type="term" value="F:choline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11474">
        <property type="entry name" value="SLC5sbd_CHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000008">
        <property type="entry name" value="High affinity choline transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052244">
        <property type="entry name" value="Choline_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897:SF4">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7169260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="505" mass="55163" checksum="984A0999D556AA1A" modified="2022-05-25" version="1">MSTWVGGGYINGAAEKVFDKGLIWCQAPFGYAISLAIGGMFFAKPMRKAGYVTMLDPLQNAFGRRMGGLLYFPALLGETFWSAAILSALGSTLAVILNIGNTVSILASAAIAVTYTLFGGLYSVAYTDVVQLFFIFFGLWLAVPFSMMNEAVGSLAPNETNWVGSIEPYSPEWGLWIDYWLLLICGGIPWQVYFQRVLSSRTPKHAQILSLTASIGCIISAIPACIIGAIAKATDWSQTDYGHTPEGYQVKLVLPLVMQHLTPPWVAFIGLGAVSAAVMSSADSSVLSASSMFARNIYKNVFRQEASEREVIWVMRAAIVVIAAIASTIGILIHSIYYLFKLCGDLVYVILFPQLLMVVHFREYVNTYGSFIAFCLGFLVRLLGGEPYIGVPATIHYPFYDEVLGQQNFPFRTVAMSVSLMSLIVASAIAKAIFTRGLLPARYDFCRCFDLGPKNKDESEELANGSLKVNGLVIPNKEDPSPLRAAEVKLYKPQQAGEQQPVGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K474</accession>
    <name>A0A8J5K474_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-1-3-glucan-binding protein-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Bgbp-L1</name>
        <name evidence="4" type="ORF">Hamer_G011604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K474"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035204790" evidence="2">
        <location>
            <begin position="16"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="12"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7168927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="309" mass="34989" checksum="9EA60DE08CDC1E30" modified="2022-05-25" version="1">MMLLCLLFLACGVFAAVVVDPKDCTAFPCMIFSDDFDYLDHDAWEHEITMSGGGNWEFQVYVNNRSVSYTRDSTLFIKPGLTSEWKSEEFLTSGDLNLWGMNGRGDVCTGNSYYGCKRVGTATNIVNPVTSARLRTLSDFAFSGEIDIVESHGNSDYGTLGNQYGSTKLNWGPYWQQNMYQKTHADYQAPTGSYADNFHTWRMNWTKDDMKFYVDDELKLTVDPGTNFWDFGGFGNSYDNPWVAGGKMAPFDQKFYIVLNLAVGGTNGFFPDDHSSWLPTWEQGEGRISEKAALQVDYVKVWKMENIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5B8</accession>
    <name>A0A8J5K5B8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">insr-L2</name>
        <name evidence="18" type="ORF">Hamer_G020192</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010014868">
        <property type="protein sequence ID" value="KAG7170190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5B8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF14">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Receptor L-domain" evidence="17">
        <location>
            <begin position="89"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Furin-like cysteine-rich" evidence="16">
        <location>
            <begin position="212"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor L-domain" evidence="17">
        <location>
            <begin position="326"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="634"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="725"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7170190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="779" mass="87397" checksum="841A97C0B4E7DB53" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6G3</accession>
    <name>A0A8J5K6G3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Sperm tail C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023231">
        <property type="protein sequence ID" value="KAG7165864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6G3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029440">
        <property type="entry name" value="DRC1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14775">
        <property type="entry name" value="NYD-SP28_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein regulatory complex protein 1 C-terminal" evidence="1">
        <location>
            <begin position="59"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="118" mass="13693" checksum="0CAF2D77CA09366B" modified="2022-05-25" version="1" fragment="single">GREEEEREEEEEEAIGGRWRGECYLVILEKSGEEGSVGAADVDEEGPLYAQEGEEAARWSSFLNNFCKRIRVWTATRDALTQYRDVLIGRLEEMRKVDRLRRENAELRFLLQGVVNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6H6</accession>
    <name>A0A8J5K6H6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019594">
        <property type="protein sequence ID" value="KAG7168686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6H6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="156" mass="16351" checksum="062FBB6E2CAFBEC2" modified="2022-05-25" version="1">MVAIQRWGRSRCCNQSPCAACGKRFEDGVVVGSAVTRLDYYMYGAVQWTVLRRRSSSSRGGGGSSSGGSCRIGVVSGSDGGRASGYSATEMGAKGGASGVGYVPRGKSKEGDDQVLCIYLGGYEERKRHVDDGAGNNRGGCSIPRDSVFVGELFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6K1</accession>
    <name>A0A8J5K6K1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Vitelline membrane outer layer protein 1-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">VMO1-L3</name>
        <name evidence="1" type="ORF">Hamer_G018568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012106">
        <property type="protein sequence ID" value="KAG7171452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6K1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.20">
        <property type="entry name" value="Vitelline membrane outer layer protein I (VOMI)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005515">
        <property type="entry name" value="VOMI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036706">
        <property type="entry name" value="VOMI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18841:SF0">
        <property type="entry name" value="VITELLINE MEMBRANE OUTER LAYER 1 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18841">
        <property type="entry name" value="VITELLINE MEMBRANE OUTER LAYER PROTEIN I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03762">
        <property type="entry name" value="VOMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51092">
        <property type="entry name" value="Vitelline membrane outer protein-I (VMO-I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="214" mass="23383" checksum="13E2487967FC3144" modified="2022-05-25" version="1">MNGSGAPGVKEVVESLKVDNGLGRGKWGSVDLCPSGSYVFAFEIKFEPAGHVDETAMNGIKMYCKDVTGTLTGYTISSEGVEGEWQGLRSCNKGEYLQSLRGNVMPEQGTFHDDLGMYNFQMNCSDGQTLDGLNDTYHPPAQEKNEIKREILTVDGREMEAIFLTTKITDDGVWSSWASCTGNNRICGHQSRVQTNSIADDAGLCDVIMFCCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K739</accession>
    <name>A0A8J5K739_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TEP1-F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Mug2-L3</name>
        <name evidence="9" type="ORF">Hamer_G011588</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds covalently through a thioester bond to the pathogen surface resulting in pathogen clearance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of a TEP1-N chain and an TEP1-C chain non-covalently linked. Forms a complex composed of TEP1-N and TEP1-C heterodimer, LRIM1 and APL1C; the interaction stabilizes TEP1-N and TEP1-C heterodimer, prevents its binding to tissues while circulating in the hemolymph and protects the thioester bond from hydrolysis. Mature TEP1 and to a lesser extent full-length TEP1 interact with SPCLIP1; the interaction is induced by microbial infection.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K739"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF171">
        <property type="entry name" value="PREGNANCY ZONE PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17789">
        <property type="entry name" value="MG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Macroglobulin" evidence="6">
        <location>
            <begin position="106"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Macroglobulin" evidence="8">
        <location>
            <begin position="202"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Macroglobulin" evidence="7">
        <location>
            <begin position="321"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00057615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00078071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7168911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="450" mass="49747" checksum="79CA760C9F437947" modified="2022-05-25" version="1" fragment="single">GYVITTPREWTAGEQAQVCVYVTNSTAPAGELTFKLTPQQVFNQANATFDPISIIKIPAGKTEVCYEVQVPKLTDSRVELHLFGTVNGVNIDGSLKITLRQTRDLTFVQTDKHLYEPGQNVKFRILTVVGANLKVSTENYPEVWVTTPASSRIAQWNNVDNPNGLVHLDVSLAKEPEKGTYRIHVKASDGGTTTRDFKVEDFVLPRFEVTLTKPKYILAVDEQFTFTVCANYTFGRSVKGNLTLTISNGERKDCEATVTHNDTISGCKDVEITARQMKTMLCNVNTLSLSAKVTEEGTNIELSARDSATIHRQAVSFKVIHEDKYMKPNLPFTLKLRASLPDDSPAAGVVMEVCAVGRCNNITTTPDGLFTTVLPSYNTDKVFIKALNSRALMRQSEYSKDLEHYYSPSNSSLVIHAPEGKLKCVPGQTQQHALPVLFSARNQDSAVFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8C4</accession>
    <name>A0A8J5K8C4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G028616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017319">
        <property type="protein sequence ID" value="KAG7169319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8C4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="159" mass="18178" checksum="AA2166FF0F4768C4" modified="2022-05-25" version="1">MKFPRKTERGAIHLRSRVVPPAGVRRSARLANKGPFWFLKDLMSCGPCVRRWCWELEDLPDNTFRLYIDPAPQTCDFPVCDIDTIPVCLTESQHVSTTINEEPCQFLVDSGVGMVDLNHESALSVGVLGRQCRWRRQPVYESGLKYQKMRVGRANNVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8X8</accession>
    <name>A0A8J5K8X8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tigger transposable element-derived protein 7-like 53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TIGD7-L53</name>
        <name evidence="3" type="ORF">Hamer_G024492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016029">
        <property type="protein sequence ID" value="KAG7169541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8X8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7169541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="282" mass="31664" checksum="DEAAD45AA0D8F7BE" modified="2022-05-25" version="1">MQMAVEKLATHLVITNFNASDGWLWRFRRRHGSVNHKVCGEAASAPTEGIEPFQKMLTESIVGEGLCFCHRCIVQRRRDFFVEIVTREYSVLAKEHSTRGRKLDKVRFSVMRAANADGTHRLTPVILKDVDDFEGSEVADYHHNMKKADEDTITEENVLEWLHSDEGDPGFQLMTEEEIAASCAAPEEDDDDSEDEDITLFGLKLSAVRAGLDTAIEYLHAITNDPSYKITTPTFQTKTDSFFHPKPPSIPAVLLHLALLLPPHLSSTQSDITVPLLSDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K926</accession>
    <name>A0A8J5K926_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Titin-like 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Tnt-L31</name>
        <name evidence="2" type="ORF">Hamer_G021729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021942">
        <property type="protein sequence ID" value="KAG7166914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K926"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="454" mass="48660" checksum="D345F70E67ADCDC9" modified="2022-05-25" version="1">MEEPAKLDIIAEVASEQSSSFSVVETGEPTADTLSPSKTVGLFDRIVNILSKDESKDVSVTAAVIEDKGEVSVTAAVIEDDGEKDVLTEDPAPVSEMKELDEKSSDVPLDAVAPTAEKEGLFDKLASMLSKDVNKEITAEQVPEDKSAAEEMKEAPVGLPQQQEVKEEIVDFKANEGEPLSATEEREGLFDKLVNVFSKKDKDTDAVEKVEESHTDQGELGEQTSTIPVKVSDTSNEKSSVLAVEQPDAVVVPETISLLDKIAGETKVPSENAAVVNAEEPVFEVKNKGLFDRLAELVSGDDKKGDLISIGESPAKSEPETLPQATAISQDVSGKSESGSSEVWRSVGSLQPVEEVPSETTEQSKDETVVADNDETFVVKAKPNSVADVGAAEYRGQQRNDAAVSAWQGWFRTGASVKQEGKDVIVQLTPPSPPVETDYGQSNPEDSDMYTTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KDY3</accession>
    <name>A0A8J5KDY3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Collagen alpha-2(IV) chain-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Col4a2-L8</name>
        <name evidence="2" type="ORF">Hamer_G028382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
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            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <accession>A0A8J5MKE6</accession>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
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            <begin position="1"/>
            <end position="18"/>
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            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7156064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="118" mass="12185" checksum="EF1F924C223B4509" modified="2022-05-25" version="1">MKVVALVFSALIVVAARASPQGYGATGSGGGSASAPAQYNFQWDVDDQQSGNFYGHGEQANNGLVQGRYYVRLPDTRLQQVEYTADDSGYHPIVTYEGEAQFGGSSGGGGSGGHGGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNA6</accession>
    <name>A0A8J5MNA6_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Hamer_G005825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7157402.1"/>
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            <end position="212"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="115"/>
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        </location>
    </feature>
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        <location>
            <begin position="953"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7157402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1014" mass="108448" checksum="D9CBA9E628136ED8" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="1">Putative Transposase-containing protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G006343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <location>
            <position position="163"/>
        </location>
    </feature>
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        <source>
            <dbReference type="EMBL" id="KAG7158959.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="163" mass="18326" checksum="EF2111C6E87052DC" modified="2022-05-25" version="1" fragment="single">MGRNKLTLHEKAWALTQLELGMCVLCVAADLKVSRQAIYNLKHAAAPLPPGAIPKRKVGSGAVRKTSIRTDNILKCEVMSDPAVTASTLRKSTQTSSNMWQSGPYNIKPLLTEAMKKKRINFCKKYQHWTSDDWKKVMFSDESTLRLVRGASKIVRRPKNVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Homarus americanus</name>
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            <taxon>Pleocyemata</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0969">Cilium</keyword>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="204" mass="22184" checksum="3FE04AA8610E616A" modified="2022-05-25" version="1" fragment="single">MKTARRTKELQLLSAIGFTGLVYPVGVGVGVWDRAGGRHAILHAHNRPITALAVKVVVWRYPERQEYGSYTVHREEVAAVGVTSGNEEYVVSLGAVQDGYLVVWHIPTRRPLCSVLAGEPGLGIATLLCTAPITPTLMVVGGTRMLRAWSLNPDNNRLTPTPISLGLLERNYTCLQMDGAEEFLYAATTTGDVVKVRLNMSTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQD6</accession>
    <name>A0A8J5MQD6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022084</name>
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    <organism evidence="2 3">
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        <name type="common">American lobster</name>
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            <taxon>Pleocyemata</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031890">
        <property type="protein sequence ID" value="KAG7159860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQD6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="214" mass="23660" checksum="8AFBA29EC99FA53C" modified="2022-05-25" version="1">MSSWTSLEPIPESSVLPPPPPLALTVTVTITDLQHSGVVMPPIRPQPRRRTRRSSRSSSQEVNYTGQENRKFRVQGDPLYLAPSSSGNSLHLEAQESTSHTHVCFRVHTFEVLRPLVEGGIVVMLETFAGGKFLRGATSGTLSLMSGGISVNNVSRFDNRFFLLHSARGDTYVTIKHLATGHFLSRGTEQVTLVNSDQGITDDMRFEMFDCTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRK9</accession>
    <name>A0A8J5MRK9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tesmin/TSO1-like CXC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G014064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRK9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="47643" checksum="3DD89922CE76B313" modified="2022-05-25" version="1">MMPCSHPWLYNQFVEEGYHTVRRTVASGLTATEGDDINCDETQKIGLEIQHSMDNQPVSDATIKRSQMDHLTRKIDKSELVRKIQMDLTNLNPKAEAQQLQQGTLVIDGGWLLHYIRRRKNATYSQVLKQYSSFLGNRHEDTDVFIMLLYHWNICMADILLRKECRRSNAGQMYNMREAYGRVTVEIRKHILFIHAWSGCDTMSATYDQGKTYLMTAEGFVKTTEEVGDAGICLFCLLYGGSRKDTLTTLGCARYMAMMAKSNRVAQQLPPTERAAHYHSLRVHLGNDSLENCTWSWKEVSGSLQPIMADKDAAPSKVLKFKWYKCKQTGKNPRSTNRYSCHKNGLKCVMACAGCRGESCNNTEPFMVIDDETNVLETYKVHKDNVMPLIHLIENKTNIALKGSHFKSLEKKFPKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUI3</accession>
    <name>A0A8J5MUI3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G014247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025553">
        <property type="protein sequence ID" value="KAG7164121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUI3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="121" mass="13057" checksum="1110FDB2065FB69C" modified="2022-05-25" version="1">MLVVTLYPSLTISLTEQKVVLVWLVVVVGVASGVPLDSNNACNRLCMATVGTLICCSRTSNSKTTTASPPLRCPVFRCTPLLPPTLLIYSVTSEENISSYCCYVDCDGEKKCISKVPLHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUU7</accession>
    <name>A0A8J5MUU7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUU7"/>
    <dbReference type="OrthoDB" id="10577873at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="300" mass="33364" checksum="67E77E8A16A76C5B" modified="2022-05-25" version="1" fragment="single">MLVPSISPGIYSCRSMCMTVVVTLLVCVCCRLFQTTLALPLDLCLEESHDKSSQIPFKDNLEFYFYMSRSNPPSTFKLILEGDDDSSEQYFKFVRNGNKYDISTSTEEMSIRMATEGWKNWTLDVNSNNHLQLTCQDRVTLKVKLQAHKDVCYNLFLLTDYNFPRRFCYPDDNNMCVRTNTIPPKTTTTTTPETTTTTTSPETTTTTTSPETTTTTTSPETTTTITSFETTTTTTSSETTSTTKAAIPAWPFTTATTSETIESEYTTTSMEIVVKEVSSAKGLPDAAGPALLLAFVMLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MV43</accession>
    <name>A0A8J5MV43_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G004877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MV43"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7165098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1075" mass="121915" checksum="15D52CEA054AEE71" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVL6</accession>
    <name>A0A8J5MVL6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G028282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024326">
        <property type="protein sequence ID" value="KAG7165488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVL6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="96" mass="11129" checksum="DE029A1711759FCD" modified="2022-05-25" version="1" fragment="single">MVIASTTIPLNMARKFTQVVALRVTVNGLVMTERRRHQLLRRIELHSQSHQKHTVSMILTEPLAYIWTGGHRTGKRNFAWYNGERFTISEWSHTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVZ7</accession>
    <name>A0A8J5MVZ7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RUN and FYVE domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RUFY2-L</name>
        <name evidence="10" type="ORF">Hamer_G020880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023275">
        <property type="protein sequence ID" value="KAG7165848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVZ7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15721">
        <property type="entry name" value="FYVE_RUFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17681">
        <property type="entry name" value="RUN_RUFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000046">
        <property type="entry name" value="RUN and FYVE domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000011">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047335">
        <property type="entry name" value="RUFY1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956">
        <property type="entry name" value="RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956:SF6">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RUN" evidence="9">
        <location>
            <begin position="42"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="601"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="409"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="294"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="517"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7165848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="667" mass="76383" checksum="46593EEA7C4DC95E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW70</accession>
    <name>A0A8J5MW70_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW70"/>
    <dbReference type="OrthoDB" id="6351848at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035296138" evidence="1">
        <location>
            <begin position="25"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="245" mass="27935" checksum="56E353D690F5F637" modified="2022-05-25" version="1">MSQRGIALTFRLLLLWAWAAFCLTQAPRDVQVKPNLISSASGGKVAAVNITCVNVEEVILEVKLIRDIINNFKDNYAQQEYFNANWTILDQHFDRSRDNISVEICDLEEKECMYVLPTLPPPPYHPPHNDHEVKNLLVIILGYIQRYTIAFETLFMDQSLYEDVFLSNMSSVHANLEDLIESLVTSVSLCDRVPNQLLIGELSVRMYKGGNTVLRNERGFRVLRQTLLGLQYIIDVLGPLVNARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW99</accession>
    <name>A0A8J5MW99_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transcriptional repressor CTCFL-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Ctcfl-L</name>
        <name evidence="13" type="ORF">Hamer_G011923</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7165996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW99"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000130">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7165996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="111" mass="12145" checksum="EE5DBAB28AE7743A" modified="2022-05-25" version="1">MNTGTEVGLGNAAPRSRGKGAVGGGKNRLCPFCPYVAATSTNLTNHIRTHTGEKPFACLLCAYTSATKENLKKHMRTHTGEKPFVCPHCPYRSAQKGSLQSHIWTHHDNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXJ3</accession>
    <name>A0A8J5MXJ3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Y+L amino acid transporter 2-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Slc7a6-L12</name>
        <name evidence="10" type="ORF">Hamer_G023529</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020576">
        <property type="protein sequence ID" value="KAG7168110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXJ3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF240">
        <property type="entry name" value="LD25378P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7168110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="514" mass="57092" checksum="5A32B66B7144C8B2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZ25</accession>
    <name>A0A8J5MZ25_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G025811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019241">
        <property type="protein sequence ID" value="KAG7168741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZ25"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="72" mass="7822" checksum="0FF5A51E559089A7" modified="2022-05-25" version="1">MAHNSGSWLGSPELRICVAQISNGVIMKRCTREESRAFRDGRGCVAGGLWSGEQVVVDCKLCYSDLECNASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZF9</accession>
    <name>A0A8J5MZF9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helicase POLQ-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Helq-L2</name>
        <name evidence="7" type="ORF">Hamer_G025671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015348">
        <property type="protein sequence ID" value="KAG7169820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZF9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF12">
        <property type="entry name" value="HELICASE POLQ-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="6">
        <location>
            <begin position="74"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7169820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="252" mass="28845" checksum="707CED68F7140397" modified="2022-05-25" version="1" fragment="single">MSRRVTTRDDIVAVIALYKVNHVLREISAQTGVALRVVQNVVKHFRDLGEDKLPAPLPKSGRPKLLSPRTLKVISRQVRSNPSLTAREVKERNPRLLSHVLLRCVQQALHDDLGFKSFRARRKPLLTKRQKENRVKFCKKYEVWDLETWRSVLWSDKATFSYSNEQKKIDVDMVGGLVGEVIPDHSCLVFCPTRRNCETLAELICKVLPTQLKQVKNREKVSLYRALVEEGGGSVCPVLRKTLPYGVAYHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N017</accession>
    <name>A0A8J5N017_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G018020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015512">
        <property type="protein sequence ID" value="KAG7169776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N017"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="203" mass="23690" checksum="0E58576AB7FC7D15" modified="2022-05-25" version="1">MYVRFWHEAPMAVRAPFNDLQLMKVLKEYPHEKVAHAAQAAISRHLWYLSEHLIGLSLFDDRIDTETKKNMVQNFQCPKKQDFSRRIVLSDETPISNVDSFVTERTLDIFDVLTLDGKERAQLFLSKDPKTWKDDEVFITMRDRAINMKVVNDSAERAIALIERYNESITQNEDQKQYLLQIVAAHRKKLPTASKAAMMKGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N018</accession>
    <name>A0A8J5N018_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen alpha-1(XIV) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Col14A1-L</name>
        <name evidence="4" type="ORF">Hamer_G016144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014436">
        <property type="protein sequence ID" value="KAG7170330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N018"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="101"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="200"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7170330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="480" mass="52554" checksum="0E239FD9D0B19351" modified="2022-05-25" version="1">MLSSQVLSEGWELQCRQDGRRSPTCLPPRWESSRWYWWPPLVGQVKEGGVAAGAEDSNTPAVATLKEEHSAAVATLKEEHSAAAHNTITRVKRQDLITLPTPTDLRKTSTGTDYVDIEWKYEGDQGSVEFLVKVYYSGAERVFAKDQVVRGTSVRVGGLAPSTTYLMSVSAFKALPRGRRATSPDSQLITAKIPDLVLSPPSNLRVTDSSRDLINLEWQYDGNQNDVEFLVNVYYSGGVLLRDLPVKGRTSVTVDGLTPDTDYTFSVKAFKALPRGLRAFSDSSPTITGTTRVTPRPTPRPQPPRTPPPSPPPPIPRPQPPETTTSPSILRPDTRPPAVGCTHGMCSCPAPNQHFCVACDRLSLCERVEDESVCSIEPAAMGVNMTVTVLSCGPQVTLNLRDFVRSDKGLLCGSATGVPVDTVVMAECWRSATYLSQCHADGKWHPYGRHQTQAPSSQHLCQPHAVNSLDRPQTSFNRYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1I5</accession>
    <name>A0A8J5N1I5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G029385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012102">
        <property type="protein sequence ID" value="KAG7171507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1I5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="64" mass="7339" checksum="8D38526FB96BB97C" modified="2022-05-25" version="1">MNVHQFFAQEGSCETMDERSCVEDSLSNSGLYEHSGKNQGRSKEIARRSNMFAKCQIFTCRRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1J5</accession>
    <name>A0A8J5N1J5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1J5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="325" mass="36116" checksum="E539B42699DE9FEF" modified="2022-05-25" version="1">MATAPSFTDGHNHTCLGILIARCVRVIQAVRVIQAARVIQGARVIQAARVIQAARVIQAVRVIQAARVIQAARVIQAARVIQAARVIQAVRVIRLRCSNIDVKEGSAVPCFDTCLKLFTMEESAHPKLRTHTSDMASPDALPDSTQDLDESLPNLTAAAAEDEEPTSSPASPEQEVVDVESYQPCVVDLTCEDEDEVDVVEVVSQEQPVIYLGTEQRRISSRRRNTSDNNAPPEVEDLTRPERYSAIDDSNDDSNNNAISAERQQNQWNFEPPAVDFHNPNLLFGNLLEDLPVATVDDHNPRPRPNLFMPRLPREMRLSTRRTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2K6</accession>
    <name>A0A8J5N2K6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2K6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="95" mass="11031" checksum="8DCDDE29A3286F94" modified="2022-05-25" version="1" fragment="single">DMWELYDLIKLYIKSSLEYHPPRTSNFSSLEMTARFETVNPYENIMLESPSPSEDQGAGSFRVEVRAMRKLYIGAVMYLQPGNFLMGVTMQARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2T7</accession>
    <name>A0A8J5N2T7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative apolipophorins-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Apolpp-L7</name>
        <name evidence="1" type="ORF">Hamer_G001096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2T7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="395" mass="43281" checksum="627EA99BF7C6E1C5" modified="2022-05-25" version="1" fragment="single">MRGYQNILMEGKLSSSAVVAMDEMLMVDGYTCSSGIRRRTTHLSHLDIGGKFSLEDGQIVDARIDMPKSELAAVSSSVKVSLYKNLQRDWEEQRSETADEEKEENCFPESLSNALGVSVCSSHSHGVHGGVVPGAPYETQVTVSKSDNFDYYVLSFRKLGNTVEALFDTPGSSYDRRVSFQVDVRPDGAEGYIVIPGRGVEGQYENTGSFKMISLQYQKNSELQGEFELSLQITKEGINTKFAPKLFLSVKNVVDVDIDGSLLLGPDVFRAEGSIMTSLQAEAARIFAKWERGGGQHKVEAGFNLGQMFISTYATLLTSPEKTMLQATCEYGSGPGQSHSLSFTLDSSQLVDNGQKTTRGYLSMQSSQAEAYVDLDFKYQPGHAEASTNISVFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2U4</accession>
    <name>A0A8J5N2U4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2U4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="269" mass="26123" checksum="5DFF6919F0ABB31D" modified="2022-05-25" version="1">MEMSSPCGSWPPPVLSPWPAPHLVVDMVEEDMVVGVVDMVAGAVEVDMAAVDMVEAGMAEEDVVVDTVEAEVMAAAMVAADMVVDVVAAMVADVVAVGMVVDVVAVAAMVAADMVVDVVVVEAMVAADIVDMASKKAAISTATTTAAIATTTAATTTTTTATISTAAAAASISTTTISAASISTAATAASISTAAAAASISTAAMSAAAAAAAAAISTSTAPATISTTPTTMSSSTISTTRCGAGHGDNTAGGQEPQGDDLRNTTETTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2W5</accession>
    <name>A0A8J5N2W5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger MYM-type protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Zmym1-L2</name>
        <name evidence="2" type="ORF">Hamer_G009558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2W5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF17">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="80"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="156" mass="17714" checksum="6DF7D581B585B425" modified="2022-05-25" version="1">MNELDHRFTGVGADLMKGIQVCHPASATFLSEEFLRKVAINYKIQMKSEEILVAKNFLARKKETSTTPDMLSVYRLLDYDMFPTLKAIFHVTLTIPVSSCSCEQSFSALRYLRTWLMSTMGQDRLNHLAVLSIEKNTLDGIEHMKSSTDLLPPPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4A9</accession>
    <name>A0A8J5N4A9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Bone morphogenetic protein 2-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">bmp2-a-L</name>
        <name evidence="14" type="ORF">Hamer_G006930</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4A9"/>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051094">
        <property type="term" value="P:positive regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000103">
        <property type="entry name" value="Bone morphogenetic protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF263">
        <property type="entry name" value="PROTEIN DECAPENTAPLEGIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0339">Growth factor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035155186" evidence="12">
        <location>
            <begin position="24"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="13">
        <location>
            <begin position="289"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7172705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="406" mass="46254" checksum="39E47462DA3073E3" modified="2022-05-25" version="1">MMLSWCWCWRVVAVLVAAAVAAAIRDGGDQKRSSPAAGDASMVRQAEQSLLSMLGLKQRPLGKGSREVPPYMWELYMQQAAQLTGAGGGVAEDNLEAHTNSPNTVRSFIHKESKADDHYPAHKMRFRFNVTNMPSDEILQSAELRLTHLRHSAAPDLQEETQPQKQKSQRRQGRRWASSEAPYLQRIMVYDILRRATRYSEPAVRLLDTHYVDAREEGVQTLDVSDAVRRWVTVPNSNHGLLVEVVQLSKSSPLDTSHVRLRRSTDDDEWYKQQPLLVVHTNDGKSKHRNKRSNTNKHKKGKEVCRRHPLYVDFRKVGWDDWIVAPPGYEAYFCKGDCPFPLPDRLNATNHAVVQTLVNSRYPDRVPKACCVPTELSPISMLYMDDDERFVLKNHQDMVVEGCGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4K9</accession>
    <name>A0A8J5N4K9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G008690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4K9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="296" mass="32714" checksum="386F7E9353D2F57D" modified="2022-05-25" version="1" fragment="single">MTTTTIATTTPVPSQQLGPINLIPTLTPDLSVAASPASTPLGGQTDVNIGSSEYVLCDVNLLWVVGGRGRCKTLAAGGAWRRVGTSLVMNLRLPSVAIFCLATMYVILLMSPMTFADVTRHCYNFTWPGTNTSLDCDEKKLDDNNKPIPCLYPLVYTVPYYNPPNITALELYCTKNVCPDFKCNEKDKKCISYSWYDVNDRLANYSLFCGSLADHTNADDPTVKSSGCWEQRVGTHTRKVCVCDDHDYCNAAFASYPVVSFGLFLMMLLPGSNYITWFTTFHVNRPQLPWGHLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N552</accession>
    <name>A0A8J5N552_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Apolipophorins-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Apolpp-L3</name>
        <name evidence="7" type="ORF">Hamer_G008736</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N552"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0758">Storage protein</keyword>
    <feature type="domain" description="Vitellogenin" evidence="6">
        <location>
            <begin position="20"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7173194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="516" mass="56718" checksum="D2095F5E33B76E64" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5Q5</accession>
    <name>A0A8J5N5Q5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="16">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">FAN1-L</name>
        <name evidence="19" type="ORF">Hamer_G024227</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 16">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the FAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="16"/>
    <dbReference type="EMBL" id="JAHLQT010009300">
        <property type="protein sequence ID" value="KAG7173607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="76364at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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            <end position="1346"/>
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        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Hamer_G003104</name>
    </gene>
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        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Malacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7174200.1"/>
        </source>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <name evidence="3" type="ORF">Hamer_G015135</name>
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                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">GMGI-L3</strain>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055445">
        <property type="entry name" value="ARM_ARMC5"/>
    </dbReference>
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        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23312:SF8">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23312">
        <property type="entry name" value="ARMC5 ARMADILLO REPEAT-CONTAINING -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24768">
        <property type="entry name" value="ARM_ARMC5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="695"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="776"/>
        </location>
    </feature>
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        <location>
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            <end position="816"/>
        </location>
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        <location>
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            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7174936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1283" mass="142996" checksum="C364A7FBBB0F30C6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8A2</accession>
    <name>A0A8J5N8A2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G028865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006656">
        <property type="protein sequence ID" value="KAG7174829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8A2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7174829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="391" mass="41990" checksum="DDA69888C92FC8EA" modified="2022-05-25" version="1" fragment="single">ASKVKLFNAVSSQLLGDSVDISLREDHGEASQVNVVESRSVTDELRLLESQIKLKEAEAKAKESDSENLRLRIQLGLTKMRSWTLSPPNGASKFSTYPCSYCGKPGHKAEDCWTRLQLNTGKPAMIVTEETNTSPVEVMADLSKADSMPIGLVFTKGVVRESAVSVLASRDFDLFQESFAKDPDVGTFSPFLSQGTVEVDGVETPVTILRDSGCLQTLIKESVVAARKTDKYVVLGSLWGQGVAPLVLVRVKSSCFSGIANVAFMHELPVAGVDLILGNDLAGGQMGNETPPPVLREKPESTAELQQLEDDMPGVSPLCAVTRSMSMTKDHNATPVVDDSLSLEGLFANPIASQDISSAVNAVTGRVALIAAQEQDDSLRLLFDSGPTTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8B4</accession>
    <name>A0A8J5N8B4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Chst10-L4</name>
        <name evidence="10" type="ORF">Hamer_G020724</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010006619">
        <property type="protein sequence ID" value="KAG7174844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8B4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7174844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="350" mass="40928" checksum="52703A9ABFE54ED6" modified="2022-05-25" version="1">MLNNVDHDKNKIKQMQSALRNVGKVWYQSNKHDFVLPHKNQENVHIQVIPKNMSEEMVPQEIYEVENDLEPDPEVFTAIAITKKNASEEISQEDPRKDQDDSNIDANTKFFLEREQVYRRRWARIKGVCNLLRGAGSYGSLSATPLHRLRWLNSHKLIMCFNAKVGTSTWLQYLMEAGYPGVLRNSSNWHHTAEIYLKPSQKRLSKITLALMNRYSKVMIVRHPFARIVSAYIDKIASSPFSKLSRYIIKRYSHQESGQTFRAPSFEEFVRYLVDSTPVEDDVRVKKKHRTNRHWFPYYANCAPCDIQYNVIATMDTKLPTNLTLALHQRYRIDFLMFGYDVTSYLSSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8J0</accession>
    <name>A0A8J5N8J0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein SmydA-8-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SmydA8-L3</name>
        <name evidence="2" type="ORF">Hamer_G015282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7175062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8J0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053010">
        <property type="entry name" value="SET_SmydA-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455:SF5">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="491" mass="55673" checksum="4C2B21685FC1EC62" modified="2022-05-25" version="1">MINKKKELGRLLVATRDLEVDDLILTEAPLVLGPKQETEPICLGCYRRVSGKYRCSRCTWPLCGPKCEVSPDHQPECDVTKAAGVTISIDDTDGGPHHLYEVITALRCLVFAGREPKRWRTCAERFNTRYLQQGAGWPQHRHNQELVVNVLRDRFRLHQYPGVDGSEAAIHTVLGLLQINQVPTKTSYSEVQALYPMASLASHSCMPNTKPVWKDGKLTLRASDPIKRGEAITFIYTDILWGTRARRDHLRQTRLLTCSCQRCADPTELNTYFSALLCRRCGNNVLPTSPLDDYDPWTCESCSSQISVEEVLRTNLALGAAVEVALAKPSIPSLEALQQEWTPRVHTNHYHLHAVKHSLLQLYGRSKEKASDQEKDAAHWIEIAKKEKSCKEFLTVCSRLDPSTAQTIPFVGLTFYEYHKTILQSAQKHFAQNKLTTQQLKKRMLLSKALLKKAMEIFKHEEEDTPEGQLYVTCEQEVIRIGKWMLAVGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N973</accession>
    <name>A0A8J5N973_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="13">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Ace-L4</name>
        <name evidence="17" type="ORF">Hamer_G009848</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="13"/>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012496">
        <property type="entry name" value="TMC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF27">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07810">
        <property type="entry name" value="TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3 10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6 13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1037"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1142"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1182"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1213"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1990"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="domain" description="TMC" evidence="16">
        <location>
            <begin position="1818"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="739"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="889"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1656"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1720"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2024"/>
            <end position="2492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="892"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1726"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2024"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2063"/>
            <end position="2075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2113"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2148"/>
            <end position="2169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2217"/>
            <end position="2233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2264"/>
            <end position="2284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2317"/>
            <end position="2328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2329"/>
            <end position="2339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2378"/>
            <end position="2387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2393"/>
            <end position="2405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2409"/>
            <end position="2428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2461"/>
            <end position="2472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="2483"/>
            <end position="2492"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 1" evidence="5">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 2" evidence="7">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 1" evidence="5">
        <location>
            <position position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 2" evidence="7">
        <location>
            <position position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="6">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10 12">
        <location>
            <begin position="240"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10 12">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="613"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-10"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-11"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7175825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2492" mass="280065" checksum="48645C073355FE91" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9D3</accession>
    <name>A0A8J5N9D3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CD63 antigen-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Cd63-L4</name>
        <name evidence="6" type="ORF">Hamer_G021871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006264">
        <property type="protein sequence ID" value="KAG7175129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9D3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7175129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="99" mass="10714" checksum="E96B042055DCF707" modified="2022-05-25" version="1" fragment="single">LECCGVTNYTDWSSVFGRGKDVTIGCCIEKTDDCFEGMAEKPIEEARKYIYTQGCYQAIKSDLQGLTIGLGVACLILAVIQVLSITCACGIAKNTQQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAK3</accession>
    <name>A0A8J5NAK3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Two pore potassium channel protein sup-9-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">sup-9-L1</name>
        <name evidence="11" type="ORF">Hamer_G009894</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAK3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF334">
        <property type="entry name" value="FI03418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="304"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7175864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="406" mass="46073" checksum="18ABCFA07F2AF80E" modified="2022-05-25" version="1" fragment="single">YGHIAPKTDWGKVVTIFYAIPGVPLMMLCLANIGDGMAHSFRFLYWKVCCYACTKRPKKKRRGRSVRSSRRYPSQSGGSTRTRTSSFRRSNRASEKSADSHLSDSAFYTSSYSDPEYKMDDDMVEADMRGLQSNRPSEHSHHTRSSQNSKGSDHLTPPPKEDEGRVAVLFNKYALEKEGITPEDGHRASGRDQDREVEMRSDGREGSRKSRRDEEADLPVTHQPRSPRVGPNPGYSDSPTMPRSPRTSERYSRHLPPPSDPRSRLSRLDEEYYYDDYDDRYDDDDDDEDLIGDKPVPIWLGVMLVVAYIFGGAFLFASWEDWGFLDSVYFCFITLTTIGFGDFVPAQGVKENVKLSIALCSIYLLFGIALLAMSFNLVQEEVISNVKNMAKRLGILKDEEGEDEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBW8</accession>
    <name>A0A8J5NBW8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002281">
        <property type="protein sequence ID" value="KAG7177470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBW8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="25" mass="2851" checksum="FC95165A74403A4A" modified="2022-05-25" version="1">MSILLLRGQYQLCEGPPNTNVQGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBZ2</accession>
    <name>A0A8J5NBZ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative BED zinc finger-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Hamer_G000024</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBZ2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Znf_BED"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_BED"/>
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    </dbReference>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="11"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7176839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="99" mass="11285" checksum="FC86B27502866821" modified="2022-05-25" version="1">MPNGRIAASGRKKDPLWYYFDRIPKGKGFRTKCKKCNQEIQGIVSRMKKHMEICQKQTSTLSEGATDEAPDEPQPTTSSETLSSPHPSTHFQKLHHHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCA0</accession>
    <name>A0A8J5NCA0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCA0"/>
    <dbReference type="OrthoDB" id="6345841at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035148002" evidence="1">
        <location>
            <begin position="24"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="356" mass="39377" checksum="D1AE0565FFDAB02E" modified="2022-05-25" version="1">MALLVTGLTVMMMMVVLMGEVDAALMAMRETPPTSPATHTLTVMDPPHYSLYQRVDVMSLDQLVMFAGMVQPYSCWCANSDNSCPVHIPAIPLHRVLKVTCGYLNIHCCLERVKAKSKEDWPFAAANITTSQELEIFFDSLIDILKPQEILLNNTLGDSEVLNQGASHNPIYPSSQQIKNNIFSEEYDIQGKPDNDSVKKRQVDVFELVLLLTLKGVAEYMMTLTAQPRMITPSFGDNSPPSFHDNEVQVQLDEYNFPSSTTNNVISSTQKNPLTNTDIYSVSNDLSVKGDFVVPYSNLGWFSRVVEVAMDGSVYVGLLLTVMFFAAKILTGALSIFGETCLICTIIGYVNETGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCW4</accession>
    <name>A0A8J5NCW4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IgLON family member 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Iglon5-L</name>
        <name evidence="3" type="ORF">Hamer_G003828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCW4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF37">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 13, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7178070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="157" mass="16906" checksum="22A2F1F4538BE941" modified="2022-05-25" version="1">MQGPSERVVAAGSRLKLVCTIKDISKTPPFVFWYQGTRMINYDSTKGVHITSEQGRSVLVVPSVSDEHAGNYTCSPANASPSSVLVHVAVETTESGAPSRRGQKEVEEADKTPVRQLGVKSASSAGPRVLPQTLALFLLALLLLDALTFPRVFQRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCY6</accession>
    <name>A0A8J5NCY6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcriptional regulator ERG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ERG-L</name>
        <name evidence="8" type="ORF">Hamer_G008381</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCY6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000343">
        <property type="entry name" value="Ets at 65A, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF304">
        <property type="entry name" value="DNA-BINDING PROTEIN D-ETS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="7">
        <location>
            <begin position="88"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7177715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="253" mass="28823" checksum="D96DDED9726D2CD1" modified="2022-05-25" version="1">MGACECVGVVKQVYWRHCGVWAWFNRGTDVIVECGRGVAGVVASPWAVWAQVGVRMPVWAASTEYLHLANSDPWPALFLPAAQGSGQIQLWQFLLELLSDPANSGIITWEGTAGEFKILEPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFRGLDQVRQQQSAEAQRYPADLSFLTSYSQLLGGLPSRWAADVTLATRRRRSSPLRHTGQRCPQPPPSPPPHHSPRPPRWRRLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ND87</accession>
    <name>A0A8J5ND87_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase 2B catalytic subunit 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Pp2B-14D-L</name>
        <name evidence="1" type="ORF">Hamer_G000352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ND87"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="56" mass="6021" checksum="4968319F6A80E36A" modified="2022-05-25" version="1" fragment="single">MRKEVIRNKIRAIGKMARVFSVLREESESVLQLKGLTPTGALPLGALSGGKASLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDD7</accession>
    <name>A0A8J5NDD7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Nitrate and nitrite sensing-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDD7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrate/nitrite sensing protein" evidence="1">
        <location>
            <begin position="10"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="181" mass="20974" checksum="F753F9ECD0AB42A4" modified="2022-05-25" version="1" fragment="single">VQISTGLGNVTEALQSERAEIAFYLFTNGSVIRGNLTEHFKYTNMLLDELKWPVFRQEHELFNNKILFRIRLDDFRDKITKFDTPSVQAGIAFYNKANYIFLDQLTSEINEKDAAGVWRPLLAYKNMIRAIEHLGISMVFGLQYFGRGALNQKSYIAFVTNDALGYDFLNTSQNFEFWITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NE46</accession>
    <name>A0A8J5NE46_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 64-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Zfp64-L1</name>
        <name evidence="10" type="ORF">Hamer_G008238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NE46"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000448">
        <property type="entry name" value="RE1-silencing transcription factor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="228"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="511"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="751"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7177594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="819" mass="88050" checksum="96799D316C8A22CF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NE86</accession>
    <name>A0A8J5NE86_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G008321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NE86"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035275947" evidence="2">
        <location>
            <begin position="22"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="422" mass="48301" checksum="600B22CA3203354F" modified="2022-05-25" version="1">MKLLGAAAALLTVVMATTVRGGPPPALDDPAALNRHLDGRFTGKQEIHNSTSSPAVHSTANKNEEHENPQTKNGAHQKESEPIRGGKDIKGNDSKKWDPTDKPKGKNIPSAFAELLPPHRYFKPLKNNLPEVNNKTRVRLARNAGIGRFAEDSFQGRKRQQNRSCCPWKDWDFNDKDDQGNKTISLEIQSNKNDVLKNPKTKPNPARVQPTYKSSILNGKRGITKDEIPYNEMTSLETEHVQHSRTLEKRAKKIGRVKNSSVTSLETQSNNRQIWNRRKDDTGGDPKVPKETQTNSRQKSWKKWDQSSGDTERDQVPRETQTISRQKSWKKWDQSSGDTERDPQVPRETQTNSRQKSWKKWDQSSGDTERDPQVPRETQTNSRQKSWKKWDKSSGDTQDDETTTFNTQPNRNNRPEAWDKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NET2</accession>
    <name>A0A8J5NET2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NET2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="159" mass="18023" checksum="81B4A621BFAA5524" modified="2022-05-25" version="1">MDKLSKRPNRQESQHDESHDRTQDYATPALHTLSEGQWAKLEVAQNKAMRAIVKAPMWTKIENLHMATGLTSLQTRAERLTACFATKVITKAWESGIKNGLLRALNLNRDVFNKKTWLFKGPDTMSPDYSTPAPWESPPAVFNILQTGTRKAHCNPHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T3E9</accession>
    <name>A0A8J5T3E9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Multicrustacea</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011273">
        <property type="protein sequence ID" value="KAG7172410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T3E9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="88" mass="10079" checksum="26C9A76D0B530C1D" modified="2022-05-25" version="1">MSRRVTTRVDIAAVIALYKVNHVLREISAQTGVALRAVQNLVKRFRDLGEESYQLHYLSLVGLNYCLHGHLRLFLDKFGPIPHSQHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T5F4</accession>
    <name>A0A8J5T5F4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Immunoglobulin I-set domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T5F4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="55"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="178" mass="19584" checksum="A760C2344C9210F6" modified="2022-05-25" version="1" fragment="single">RPIHVTEGGVAVYRSREVEVEMGVKGTVVARSLTLTTPWLQEFGPVQVLSTSRIPKLSVGPVSAEFTEGSVLLLSCPVYGGPLLKVSWFKDTNLIYSHTVPACSYDGGTSRLRVVTERGTSDYECTIMMWVFRPAQVDRGIYVCQVTDRGYLASQMVVAGSNQSLQLDMTPRVLTIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5THK7</accession>
    <name>A0A8J5THK7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G016423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5THK7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="63" mass="7589" checksum="DB002D4728462240" modified="2022-05-25" version="1">MRQWTLGQVDHWTTGPLDQVDLRGWTQGVLWVTLGQPVWWCSEFHWTRDEGEDSHYWRATCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJB8</accession>
    <name>A0A8J5TJB8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G015363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Multicrustacea</taxon>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJB8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="88" mass="10646" checksum="C6D2B43B19F6EAB5" modified="2022-05-25" version="1">MQYITLVFHQTTYSFLWFYYYKVYGNYKPLFRDSRVQIIRNLTFMINSFDNWCNELSEPVRYYYTEAGMNKGSPVAEISICKSYIKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJF3</accession>
    <name>A0A8J5TJF3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD repeat-containing protein 47-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Wdr47-L2</name>
        <name evidence="3" type="ORF">Hamer_G015450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJF3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057749">
        <property type="entry name" value="WDR47_COR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF11">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25602">
        <property type="entry name" value="WDR47_COR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7176639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="662" mass="74727" checksum="F6F751A032392865" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJV8</accession>
    <name>A0A8J5TJV8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nudix hydrolase 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NUDT8-L</name>
        <name evidence="5" type="ORF">Hamer_G009193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJV8"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04670">
        <property type="entry name" value="NUDIX_ASFGF2_Nudt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000016">
        <property type="entry name" value="nudix hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000015">
        <property type="entry name" value="Nudix hydrolase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003293">
        <property type="entry name" value="Nudix_hydrolase6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040618">
        <property type="entry name" value="Pre-Nudix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994:SF13">
        <property type="entry name" value="FI03680P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994">
        <property type="entry name" value="NUDIX HYDROLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18290">
        <property type="entry name" value="Nudix_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="99"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7176386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="285" mass="32905" checksum="FB58833A28B6B33D" modified="2022-05-25" version="1">MEAPVQFKGARDRFSGVTISSEEEPASPQEFEAVLQASMSHWMEENIRGVWFKVDLEHADWVPVLVKHGFIYHHAQPQFVMMVKWLSVNEPNNIPRYAHNVVGVGAFVVNDQDELLVVRERFHTRPHWKLPGGYVEPGEDLGTAALREVKEETGIDAEFVSLVSFRHVHGANYNCSDIYFIVHLRPITQRITMCQRELTACEWMKLQEYVQHPYVHETNRFFAERFLECRRNGVKIQATNIFSPAFRKNQVIYSINSKVEKESINEKAENSSIDTQSLMNGDAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKL7</accession>
    <name>A0A8J5TKL7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cuticle protein 21-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Cu21-L3</name>
        <name evidence="3" type="ORF">Hamer_G030001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008154">
        <property type="protein sequence ID" value="KAG7174017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKL7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37458">
        <property type="entry name" value="THISBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37458:SF1">
        <property type="entry name" value="THISBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="608"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7174017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="835" mass="97276" checksum="D08EAB73BABD7FBA" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TMB0</accession>
    <name>A0A8J5TMB0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TMB0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="544" mass="59393" checksum="2109B5D27FC89FBA" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TN11</accession>
    <name>A0A8J5TN11_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gamma-1-syntrophin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Sntg1-L</name>
        <name evidence="5" type="ORF">Hamer_G025078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001770">
        <property type="protein sequence ID" value="KAG7177795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TN11"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015482">
        <property type="entry name" value="Syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055108">
        <property type="entry name" value="Syntrophin_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554:SF1">
        <property type="entry name" value="FI16515P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554">
        <property type="entry name" value="SYNTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23012">
        <property type="entry name" value="Syntrophin_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Syntrophin C-terminal PH" evidence="4">
        <location>
            <begin position="449"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7177795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="553" mass="61807" checksum="3B0A56CCB0CA599F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TN14</accession>
    <name>A0A8J5TN14_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005507">
        <property type="protein sequence ID" value="KAG7175562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TN14"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="493" mass="54719" checksum="1730A13E513F9DC3" modified="2022-05-25" version="1">MASSFYHSMVPQPTFVPPAQNTVQQESPKEKKKRTRNPENWKKEKRKRAILSGQAYVNTKGELVGPRAIGPDCNCKNKCFTAVSDDNRNAIFNGYYSLNSYDEQNAYLYGLIRRHDIQRKRKPVSERRTCSYKYYIRIKGKEIQVCKKAFANIHGISDKKIRTLCIKHEQNILFPRDNRGRHRNRPKKHHILKMLSGPNGSDYIKTDKNQGPDVNISKLHKSFLQQYEPEAIDQETDKVIKDYDAKVKSWLYFKVFHEEFKSMDFNTVKRKLSDLRKSLEASGALQATKKKTTKQSRPRPRPQENQVARNATPIDASTSSLGVAVSAAPATQMGGYMGQQPPTLPPNLQLSVLGLQHLGNNSHAGAAFNPTAAAQQPQQQPLNLQTGGGGEQPQPLPLNLHSMGGHMPSYYLSLGHMSNLISLPVSSGGGVQGANTQSGNFPGQHNMQQFNPGSIVPSHSVAQTAPGPAGQPHLLQGGVGVTYAGPQHNHAMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TNE8</accession>
    <name>A0A8J5TNE8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G009910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TNE8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="76" mass="8478" checksum="727F0C68BC6391A2" modified="2022-05-25" version="1">MRCGAGHNSRLIVLMYPFKLCGCGEFAGPTRPTGLVRYRARTLQSVDKESKVGSLYAAARRMCGRKPWSLRCGDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JA26</accession>
    <name>A0A8J5JA26_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyisobutyryl-CoA hydrolase, mitochondrial</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hibch-L</name>
        <name evidence="9" type="ORF">Hamer_G019963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010044137">
        <property type="protein sequence ID" value="KAG7154545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JA26"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="8">
        <location>
            <begin position="41"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="8">
        <location>
            <begin position="234"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7154545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="336" mass="37029" checksum="B62AAE86FD92ADF4" modified="2022-05-25" version="1">MVVAQITSRLRTLVRPLMMASSRNLSSSAPEVLLEEVGNKGIITLNRPKALNSLNINMIRLIYPKLQEWETTKSMVIIKGAGEKAFCAGGDVRSIVETVNDPNPVGEYFFREEYILNCLIGTLHIPYVALIDGITMGGGVGLSVHGQFRVATERTLFAMPETGIGLFPDVGGSHFLPRLGGRLGMYLALTGHRLKGREVMKAGLATHVCDSARIGELEESLLKMESNYPEDVAAEGSEWSQKQLAILGKMSPTSLKVTFEQIERGANLTLPECLSMEYRIVSHIYKGHDFAEGVRAVLIDKDHKTSWKPATLADVPTDEVIKKHFDPLEPQKELTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JA74</accession>
    <name>A0A8J5JA74_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Dohh-L</name>
        <name evidence="11" type="ORF">Hamer_G009479</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JA74"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000099">
        <property type="entry name" value="Deoxyhypusine hydroxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="10">
        <location>
            <begin position="225"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7153791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="310" mass="34297" checksum="32FC1511D4EC40CA" modified="2022-05-25" version="1">MVPDSIIEAIGQVLEDQNRPLKERFRALFTLKNLGGEAAIVAISQCFSDPSALLKHESAYCLGQMGDTRAIPTLTKILKDVEQEPIVRHEAGEALGAIGDPSVLDLLRSYSKDPVTEVAETCQLAVGRIEWFQKESNKGEKFEGADKFFSVDPTPPATDTDVEKLRERLLEESLPLFDRYRAMFSLRNLNTPESAKALAAGFKCSSALFRHEIGFVLGQMSNDVVVKELTAVVQDENENEMVRHEAAEALGSIATVAAMAVLKEYQRDKARVVRESCEVALDMSEYENSSEFQYADGLLKIEQNENGMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JC83</accession>
    <name>A0A8J5JC83_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044612">
        <property type="protein sequence ID" value="KAG7154278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JC83"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="78" mass="8344" checksum="AFF59DA0A0FC40DF" modified="2022-05-25" version="1">MWGVGVAMKEQSKCERGHGGAQQMKSIVAVVAVGVVWACVMGVCEGRPQFIDTITSPFNQAFDTTTNFFSGAGNMITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCH6</accession>
    <name>A0A8J5JCH6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase kappa</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Polk-L</name>
        <name evidence="20" type="ORF">Hamer_G019995</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010044137">
        <property type="protein sequence ID" value="KAG7154574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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            <end position="444"/>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1585" mass="175811" checksum="053E5A762BA1DC83" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JD05</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7156147.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5JFF2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        <name type="common">American lobster</name>
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        <lineage>
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        </lineage>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="134" mass="13752" checksum="08FEC4C8E1110CB4" modified="2022-05-25" version="1">MEGEGRSGVGGCGSVCCEDCCEDCCEDCCEDDVYWCGGCGSVVRMCNGCVIGCVSGCVVCCEDAVRVVCEDCCEDWCGGVVVCGGFVWCGGVVVVFVGALCGSVCGDFVWCGGVVVSSVWGGCGSRKLWSVLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JID8</accession>
    <name>A0A8J5JID8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G011238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
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    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="791"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1054" mass="115976" checksum="6830CA236AD0EE14" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJR6</accession>
    <name>A0A8J5JJR6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminoacylase-1-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Acy1-L3</name>
        <name evidence="4" type="ORF">Hamer_G015994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041065">
        <property type="protein sequence ID" value="KAG7155623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJR6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000005">
        <property type="entry name" value="Putative Aminoacylase-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052083">
        <property type="entry name" value="Aminoacylase-1_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892:SF1">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036696">
        <property type="entry name" value="ACY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="45"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="4"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7155623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="253" mass="28567" checksum="AF61BFD9722A1FA2" modified="2022-05-25" version="1">MTDEEIGGIDGMAEFIETDIFKKLKVGFALDEGYANPTEKYTVFYGERTVLWVYVKCPGQPGHGSQFLPNTAGEKLQRVINSFLNFRSQQKQLLKEDKDLNLGDVTSVNLTMLQGGVQFNVVPSELCVGFDVRVTPTIGENKFEDMIKSWCKEAGDDVTYEFKHIAPGSHSESKDEYPNLTCVEDGKNPWWDAFSQACKDEYVLVNIPALGFSPMNKTPILLHHHNEFLNEKIFMRGVEIYTTIIPTLANLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJT8</accession>
    <name>A0A8J5JJT8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tubulin polyglutamylase ttll-15-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ttll-15-L</name>
        <name evidence="2" type="ORF">Hamer_G016045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041065">
        <property type="protein sequence ID" value="KAG7155668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJT8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053317">
        <property type="entry name" value="Tubulin_polyglutamylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47113">
        <property type="entry name" value="LD09343P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47113:SF1">
        <property type="entry name" value="LD09343P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="543" mass="62206" checksum="8DF0DAEB4140163F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJU9</accession>
    <name>A0A8J5JJU9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G005806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJU9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="307" mass="33026" checksum="C9C5DCF024DADDD2" modified="2022-05-25" version="1">MYCMCRRACQAKIDCHSVSMVPTTGTENECRISTKPANIGDKTQRPRLKRTPGAFHFLAAVKGTNEWITLLDDGFKWRTESNTYIWSFRLNGARLAILSSLHQVKLAMRDTTVNKPYYVDLSRTGTDQPVWNAGGGNVKYNDTDLDPTRIQDDPNLSNSKFYFTHDDHAGVDVVDLALTSLADITDLALTSLSDITDLALTSLADITDLALTSLADITDLALTSLADITDLALTSLADITDLALTSLADITDRALSSSGGEGQVSNVCQGGEGQVSNVCQGGEGQVNNVYSGVVLGSSETSHVVVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKG4</accession>
    <name>A0A8J5JKG4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transforming protein Ski-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">V-SKI-L</name>
        <name evidence="4" type="ORF">Hamer_G022108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031890">
        <property type="protein sequence ID" value="KAG7159882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKG4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21079">
        <property type="entry name" value="DHD_Ski_Sno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.20:FF:000002">
        <property type="entry name" value="SKI-like oncogene a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.20">
        <property type="entry name" value="Ski"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014890">
        <property type="entry name" value="c-SKI_SMAD4-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003380">
        <property type="entry name" value="SKI/SNO/DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037000">
        <property type="entry name" value="Ski_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023216">
        <property type="entry name" value="Tscrpt_reg_SKI_SnoN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005">
        <property type="entry name" value="SKI ONCOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005:SF25">
        <property type="entry name" value="SNO ONCOGENE, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08782">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02437">
        <property type="entry name" value="Ski_Sno_DHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01046">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="c-SKI SMAD4-binding" evidence="3">
        <location>
            <begin position="320"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7159882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="430" mass="47097" checksum="E446161E3F614AD7" modified="2022-05-25" version="1">MATPDYSPLLKRVLRSYQNAAMTSLHGPGPNSYLTDTGVNKKLAECDEEPPSIKLLDAHTKQEIYREVSFKKALLYEDSLKNKTVDICRRCVDDSECRRASPPSPPTNHTPTSPTRDPQPRLPDVKDTPVDTTSTAISSPTASVVRNSVSDTCTSDNSSNTTSSASSSSGGAGGSWVEPGVFLAPAPFPPQPWPVLAVADKGSPGAGRGREETLLDGEPIACFNVGGEKRLCLPQILNTVLREFSLGQINAVCDELRIFCSRCTPSQLEALRVAGVLPHTARSCGLITNTDAQRLTQALLHAHPTRAPAPAPTQPQDHPHLRVYHTCFGKCKGLVWDDLYTSAGAACIECEECRGLFPPARFVCHAHRALENQTIHWGFEAEQWRIYLLLAKDQQLPLEKAEAQLKTFKNKFDPAGANYKRKQVSFHYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKQ1</accession>
    <name>A0A8J5JKQ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative crustin-like antimicrobial peptide 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G026001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043531">
        <property type="protein sequence ID" value="KAG7154899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKQ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035222039" evidence="1">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="2">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="113" mass="12794" checksum="AEEF3BE8C589F056" modified="2022-05-25" version="1">MMKLWLVVCVVGGWQVSQGAGQLPCLADPIQPDCIAFCPNNYNGEYFCCDTNGNNPGQCPKYRLTADERSLLCDPTQHNYPYHLNCKSDTDCFAWEKCCYLPENNQRICRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JL63</accession>
    <name>A0A8J5JL63_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JL63"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="116" mass="12768" checksum="FB71852D844978B5" modified="2022-05-25" version="1">MSCELVAVVPVTGVYGAEKMSCELVARTHKDRTADGRYKRRRGTYINFTPRHIKIVLGGIAPLGHNVYVAMPCRCASSSASTGVFPSVFLAPNLRPKRLQRAPPRRPYDPSPLVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMQ7</accession>
    <name>A0A8J5JMQ7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Breast carcinoma-amplified sequence 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rudhira-L</name>
        <name evidence="3" type="ORF">Hamer_G001793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048382">
        <property type="entry name" value="BCAS3_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21034">
        <property type="entry name" value="BCAS3_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCAS3 WD40" evidence="2">
        <location>
            <begin position="75"/>
            <end position="491"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="23"/>
        </location>
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            <begin position="432"/>
            <end position="451"/>
        </location>
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            <begin position="495"/>
            <end position="522"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="807"/>
        </location>
    </feature>
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        <location>
            <begin position="900"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1158"/>
            <end position="1189"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="787"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1355"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1396"/>
            <end position="1405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7160516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1405" mass="153042" checksum="0177FEFCC2BD47A2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JN44</accession>
    <name>A0A8J5JN44_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Mcm4-L</name>
        <name evidence="13" type="ORF">Hamer_G016597</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JN44"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase"/>
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    </dbReference>
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        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="12">
        <location>
            <begin position="440"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7159206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="847" mass="95520" checksum="91362898EAF5E444" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNC6</accession>
    <name>A0A8J5JNC6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pro-resilin-like 172</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G028852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028990">
        <property type="protein sequence ID" value="KAG7161522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNC6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7161522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="97" mass="10761" checksum="45E31F388665DB55" modified="2022-05-25" version="1" fragment="single">GPAQYNFDWSVNDANSGNDYGHNEGRNGYDTQGSYYVQLPDGRLQRVTYTVNGDSGYVAQVEYEGEAQYSAYQPAPSYQPAPAYRPAPTYTPTPSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNT9</accession>
    <name>A0A8J5JNT9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035987">
        <property type="protein sequence ID" value="KAG7157948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNT9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="72" mass="7756" checksum="6EC88F1BD4F37ECC" modified="2022-05-25" version="1">MVVVVVLVRDRDGIISQQWTTPTTALQRDKLLQRAGDTAFTAAERVTASQQIGLEVQESPDLQASAEDGDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPL6</accession>
    <name>A0A8J5JPL6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Zinc finger, C3HC4 type (RING finger)-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Hamer_G015852</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038275">
        <property type="protein sequence ID" value="KAG7156924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPL6"/>
    <dbReference type="OrthoDB" id="264520at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051435">
        <property type="entry name" value="RING_finger_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791:SF6">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7156924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="503" mass="56628" checksum="1CCADE272CB15E0C" modified="2022-05-25" version="1">MRACKTGAPEGEAPPTHCPICLDAWDAQERLPKFLSCHHSVCVSCVDLLYQAALTQAPPTSPGSPPTPTSPLGRFMGSRSSLNGVLEPEEQGGSSWVKCPLCRSSTLIHDPHTLQTNFYLRGLLRAPSVPRLVLWCDTCSTVAAPSCAHHHHRPLQDKMCLLQEELVAAAGEACGWACGRVAEYESQVEVYRWVCRLLRHAHTQVLTTLTHVQHQHRALNRYNKEVLALVNRGEVLQGSQELEEEAINGLETVVQEVKDKHEEKIADDDPLTLTDTFHLSANHRGPQGYHRALLVLEADEALTLSIYGEKEREKRDVEDTNDEERDTEQKRRFYSLQENRRKEFSPKAKMKVTRSFSLHEPSDGVLLVPDRAEKETPAVSQHLVQPSPSRPKPNTRVRETNNIYEPEDPISEPFTQVTASHSFTMPKKPPVEAPPSRDNKRVANPSPVNSNTNQTTVDARDRRIGDGNGRHQRRNRQAEPTPRDHQRQRPQRRRKGKSGCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPM0</accession>
    <name>A0A8J5JPM0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative extensin-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G017491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7160038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPM0"/>
    <dbReference type="OrthoDB" id="6360263at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7160038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="286" mass="30835" checksum="628860C085D44D9D" modified="2022-05-25" version="1">MDGFFLSMFLAVCIVAAVVIRFVCYRLACARQLLTRDDQSMLPRNTTPVIMPAHASRQQRTPQLPHNITDSPLVTRGSEVFTIYTFSQQSTPEQERARRITPPPKYSMLSDVPPKYEDLFPLPNCTPCKVDNCLSPASLHHLQHSSSAPPSYASYTTKPPALTSPSDSSCPVPTTSNTPTTCSADTSIPIPSTNPDNVITPDDSTSSPDSSHPAYTTDTISHTPTTSQTDTTGPLPSTSSTTSPANTYTSSGTQTSLSLYPPPVIRVEPADDLPPHSTILVPEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ54</accession>
    <name>A0A8J5JQ54_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034162">
        <property type="protein sequence ID" value="KAG7159044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQ54"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="65" mass="7140" checksum="1E6F14E14FA73E82" modified="2022-05-25" version="1">MAALTDYTQAGSVMTATHWLHPKLDLSQLPLTRTPQAGSVMAATPRYTSWICHDCHSLVTKLDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQS6</accession>
    <name>A0A8J5JQS6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sodium/potassium-transporting ATPase subunit beta-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Atpb-L</name>
        <name evidence="3" type="ORF">Hamer_G004060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQS6"/>
    <dbReference type="OrthoDB" id="5912413at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF28">
        <property type="entry name" value="NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="323" mass="36756" checksum="4A2BF98DA95B3CAC" modified="2022-05-25" version="1">MADQQPTISFTKGDAKRTNGEVDTKIPTYNRAPPRHRSTGDAMKSFWWNPEKREFLGRTGVSWGKIGLFYLVFYSFLAAFFAACMAAFYTTLDTEHTPKYTGDESLLANPGLGIRPRTNLEENHPVIIYSPSGSFSYGDYIDSIDDFFKTYNNRSDLQSKYINCKEDDHIITGEICDFDLGMTKTSCTQEDNWGYTTNSPCILLKLNKMIGWLPHPTKHFSSLPQGLQDHINSLNDTNALSKNVWVWCESQEVEIEQPAPGLPLSFFPYTNQPGYLAPFVMVRLIDVPLEVDVKVKCRAWADNILPRMNRRALGQLDIDIKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQV5</accession>
    <name>A0A8J5JQV5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQV5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="175" mass="20077" checksum="1B16E44072016BDB" modified="2022-05-25" version="1">MIRYEESGKLTDLPRPRRPRLTSAADDFRIVADIRDLPFTNAVATTERLHLEVLGKAVGRLRFTDHYVWEDLNFWATTAVFTDGDLITPLRLAACLSRSQELPRDRKHVGLDQPQQQGQTHAWATWKAYDEVTTAFLAMSFKPTKDKVEEIMSAIECFVVLMYDRMSSCTGYDCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JR34</accession>
    <name>A0A8J5JR34_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Casein kinase I isoform alpha-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Csnk1a-L2</name>
        <name evidence="3" type="ORF">Hamer_G025562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027687">
        <property type="protein sequence ID" value="KAG7162586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JR34"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7162586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="240" mass="26320" checksum="721906347C8A10AB" modified="2022-05-25" version="1">MEKIDTWGDTACDDSTWDDWDVPVHCPVSQVPSFLPAQDDNAHNPDTSSALSHTLEPEPLPLLSWDHLECGDKIGSGQCGVTHLGMLTLDDGRTTEVVVKMLHGGSPLTAEARTLQEVAGAGGAPLLHGVATNPNALVMQYCPGVTLQAMLEEYDLQQCYDAYKATVEAVNCFHTAGFYHQDLHPGNIIINTSVLPYTSHLLDLGYTRRFTGQLVRDDNAKSEDLFCLKQIKDQIDAKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRI1</accession>
    <name>A0A8J5JRI1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Synaptogenesis protein syg-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Syg1-L</name>
        <name evidence="2" type="ORF">Hamer_G026863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026771">
        <property type="protein sequence ID" value="KAG7162885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRI1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="40"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="142" mass="15612" checksum="DED2E6749EF86116" modified="2022-05-25" version="1" fragment="single">MSLVVQRVTRGHGGDYTCEASNIKDTSSSPPLHLDVKYAPVCARQERVQHSVAKLENAEISCRVHANPANVTFRWTFNNTAEAIDVPDGRFVVAGTESRVNYTPMNELDYGTLLCWANNTIGLQQHPCVFHIVAAGELSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSK3</accession>
    <name>A0A8J5JSK3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031541">
        <property type="protein sequence ID" value="KAG7160243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSK3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="222" mass="24286" checksum="6DE5583A9BF875FB" modified="2022-05-25" version="1">MEWQVVVVVVELKWCVLGFRSCGVGWGGVGWVGWGVGEWGGTKKGDGWREGTRMEGDRWVNRGRMADKKEGRKEGRKEGRREGGKGREGVLRASCVGEKSCNDMYSGGVGEWGSGEVVVLLHVLRGSVEVVVLLHVLRGSGEVVVLLHVLRGSVEVGKWGSGEVGKWGGGEVCSGKRCWVKQCLGKWCWGSADMFGWQCWVSGQRGVVKVGSLWFYPTTAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTB3</accession>
    <name>A0A8J5JTB3_HOMAM</name>
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        <submittedName>
            <fullName evidence="7">Facilitated trehalose transporter Tret1-like 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Tret1-L26</name>
        <name evidence="7" type="ORF">Hamer_G023975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028027">
        <property type="protein sequence ID" value="KAG7162071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTB3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7162071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="251" mass="27330" checksum="3E7282AEC166A979" modified="2022-05-25" version="1">MNVMRQTQEEARQNTVSMDELKKPYIVKPLVISCILMVLQQLSGAIPVLFNMSLIFKTAGSGLPADVNTIIVGLMMAVSAVVAGALVDTAGRKILLIISAAAMTISLTALDVFFYQKFLDEDRAIENLSWLPLICLIVFVTAFAIGLSPVPWVMTGELFSLNVRGPANGVASMVNWTMSFVVSLAFQPLQAAIGPYGIFWFFAACCAISIIFCILVVPETKGKTLQEITRQLGGPDTTEVTLKKQEEISRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTL2</accession>
    <name>A0A8J5JTL2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sex peptide receptor-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SPR-L1</name>
        <name evidence="8" type="ORF">Hamer_G006348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTL2"/>
    <dbReference type="OrthoDB" id="5962323at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053071">
        <property type="entry name" value="GPCR1-related_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023:SF1">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7158964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="387" mass="44844" checksum="1624B6F4DA1B5180" modified="2022-05-25" version="1">MEYDTLNDTNITTCGNDTNSTHDFLNVSSMYPLDLAVPLYGYAMPVLLLVTTVFNTLIVAVLWQKHMRSPTNAVLTAMALSDMLTVVFPEPMFFYMYTLDNHAKPLYPPAACYAWNFLHDYIPNVFHTASIWLTVALAAQRYIYVCHPPVARTWCTLPLVFKAIIWIFVFATIHQAPRFFDTVYESVEVEWGGECVDVCRETFNYWVTLITPNIYFPIYFWFRVMFVHLGPCMVLVVLNMLLYRAMKEAQKRRKKLLHDKNSKKECKTLRDSNCTTLMLIAVVSVFLVTEIPLAVITLLHIISNMFVNVFSTESYEMLMYFFIISNSFIIFSYPINFAIYCGMSRQFRVTFRDLFIRGRPPKAERDGSTRYSMNNGPPRTCTSETVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUE3</accession>
    <name>A0A8J5JUE3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PiggyBac transposable element-derived protein 4-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PGBD4-L4</name>
        <name evidence="3" type="ORF">Hamer_G016321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUE3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF6">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="199"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="674" mass="75016" checksum="3874BC8422DEAF0B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUG0</accession>
    <name>A0A8J5JUG0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUG0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="251" mass="28864" checksum="A1967BC70EBB21BC" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIVNAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVA3</accession>
    <name>A0A8J5JVA3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G005196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVA3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="227" mass="25012" checksum="8BAE81057CDD9362" modified="2022-05-25" version="1">MEVPRDTSNKRPIGKVFIPATAIGTDLSKVLSCPITPVPASLAYLKGLINKTGKTAVQKKLETKVNSQLPFTVDVCVTDAMFLIRSLVDLPAANGGVAGVLLSKLCAHARCVDFVCDTCTSPSIKDNERHMLGAIEVNIVTADPEQKRLKNVNQALSFGLFKISLYKLLAAGWEQDTYKEMIDGHEIYLALEEVCYKFEVKRGSVFRQIVPELGRQHEEADSRLICM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVQ8</accession>
    <name>A0A8J5JVQ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative olfactory ionotropic receptor IR4-like 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ir4-L28</name>
        <name evidence="2" type="ORF">Hamer_G026669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028331">
        <property type="protein sequence ID" value="KAG7161998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVQ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035236484" evidence="1">
        <location>
            <begin position="18"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="194" mass="21676" checksum="169F9FF73AFAC93B" modified="2022-05-25" version="1" fragment="single">MMYVTSLLGLFIVLASSGVPRLPRLQDRPLIAAVEDVLASVTDPYCFLVFITDGSTWPIALYKGIHHYHAPWGVGAFEVVVDGQNANVTQAQLSWVVDEARRLRQVSWCVTVVVVSDDPAFLVTFAELSVKGRLLVWSSRLLIVTRPFLLELQGLHKLLSLNNAMLLIMDESSTSRQLLSVPVFCLFTLKHLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW68</accession>
    <name>A0A8J5JW68_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF885 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G004520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW68"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361:SF2">
        <property type="entry name" value="DUF885 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="GLR0591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="69106" checksum="9A7B0DCCDE46B9DF" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWD4</accession>
    <name>A0A8J5JWD4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">39S ribosomal protein L9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mRpL9-L</name>
        <name evidence="2" type="ORF">Hamer_G004861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWD4"/>
    <dbReference type="OrthoDB" id="5555409at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_bL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="1">
        <location>
            <begin position="95"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="292" mass="33220" checksum="E281609E90C79655" modified="2022-05-25" version="1">MLRSVVQGLANLHLKNTGLAISRGAGRTLTAKDVETKVCGGPLLQQVRTTFILKRVSKSLLRKTHKKTSSRKMKARDFVYKLVEDTNVRKKEPLKVILLASVDGLGSKGQIVEVKPSRARYHLLLPGLAVYASPENIEKYSNIMKQVSEDEDQPSSQFARKTVQELSSRVISVSMNMKNPWKVEPWHVRVAFRKAGIVLPEEALTLPSNPIVGPDLSLQEKEFLVKVKVNNKEEAPVRCRIHHYATNPRERIPWKGFHWEYPAEPLFLEEAPVLEELTKNNPITRYVEEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWH0</accession>
    <name>A0A8J5JWH0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Elp2-L</name>
        <name evidence="12" type="ORF">Hamer_G025174</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027690">
        <property type="protein sequence ID" value="KAG7162584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWH0"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="200"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7162584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="740" mass="82238" checksum="FC982487EEFF5CF4" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWU4</accession>
    <name>A0A8J5JWU4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="4">2.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2 large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2B</fullName>
            <shortName evidence="4">MOCS2B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MOCS2-L</name>
        <name evidence="5" type="ORF">Hamer_G002972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + cyclic pyranopterin phosphate + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26333"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="EC" id="2.8.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MoaE family. MOCS2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWU4"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00754">
        <property type="entry name" value="Ubl_MoaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.40:FF:000002">
        <property type="entry name" value="Molybdopterin synthase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03052">
        <property type="entry name" value="MOC2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028888">
        <property type="entry name" value="MOCS2B_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="227"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7163736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="266" mass="29698" checksum="209D7447839FDFFD" modified="2022-05-25" version="1">MTEREVLVTVLFFAGARDLAGVDRSAVTLTAITTPEQLLAQVVRSFGEIAKIRESVIISLNQEYCEPGQWLVLSTGDEVAIIPPISGGMSLIFRTVINNIQLGIMDYIKLTQDVLSVEEITGLITNPSCGAISLFVGTTRNNFQGKNVVRLEYEAYHEMAEKEMGKLIKEARNKWSLKHIALYHRLGLVPVTESSVIVAVSSEHRRESLDAVSFLIDNLKANVPIWKKEVYSDGSDDWKKNKECVWVKEEDGQDTVDKIINNNKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWW2</accession>
    <name>A0A8J5JWW2_HOMAM</name>
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        <submittedName>
            <fullName evidence="3">Putative F-box domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G022384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023413">
        <property type="protein sequence ID" value="KAG7165825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
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    </dbReference>
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        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="302"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
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            <begin position="71"/>
            <end position="86"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7165825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="495" mass="52975" checksum="74984D78692D9CCE" modified="2022-05-25" version="1">MEFPEDFTHKNDACFHCTGFYGPNFIQPLCTTCHSFLYPDDPSKLPSVGPYQEKTDDGDSGNEEPREPGDYYQTQEQVQQPQQQQHYQLHHIEQQFQQQAQQQEGSVGTNVLVNSETETDDYDFVEGAAADSMDVGISESPIASAVELSGAGISTGMSGTTGGQPLASIAGTSGTVSVGILGSMVGGAAASVGVNSSAGMLAMGSSGGGLPGATGGLPGAGGGLPGAGGGLPGAGGGLSGPGGGLSGRNIAGQGGGGGSLRLPDTRRPLVMNADGRMVAVRETLQEQIINLTCPRPPENLDPTLIHRMPPEVWVLVFDLLDDMTLWSVGRVCRRWQELVNRYVSDDQWQKYTQCRWPLYTPLFKDVPWQMVYTKLTESAPCHMCLHQMSLLTPPHNSENSWRRNRLRNELRSTTVCMEPEIGRLYDTDKKQFECVATSWTWKHAMHDALIPEPVQTPTLRRSFGTCGTSSGVSSEDGPSASGAGADSESDLVFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXL6</accession>
    <name>A0A8J5JXL6_HOMAM</name>
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        <submittedName>
            <fullName evidence="1">SCAN domain-containing protein 3-like 2</fullName>
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    </protein>
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        <name evidence="1" type="primary">ZBED9-L2</name>
        <name evidence="1" type="ORF">Hamer_G002069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="146" mass="16526" checksum="F31572D930954426" modified="2022-05-25" version="1">MFENVVGTQGAGSRRGDIGDVNVLPGCQSPFLDSGKPHVYFPESESEHLNSSMWVLNSFANDGVNHSEALLELRMNYTQKATFKTLVHTMYFWVTLMDIPENKELAEQATTMLVQMPTSYLCEQGFSALVRNRDPRAMMNRKCQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXQ1</accession>
    <name>A0A8J5JXQ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0612 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXQ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1184"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        <location>
            <begin position="1164"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1232" mass="130288" checksum="9A96AF3605EFA80E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXY6</accession>
    <name>A0A8J5JXY6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3179"/>
            <end position="3215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3264"/>
            <end position="3296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3503"/>
            <end position="3529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3552"/>
            <end position="3602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1548"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2772"/>
            <end position="2794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2808"/>
            <end position="2818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3003"/>
            <end position="3012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3063"/>
            <end position="3077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3078"/>
            <end position="3090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3188"/>
            <end position="3215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3283"/>
            <end position="3296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3503"/>
            <end position="3517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3570"/>
            <end position="3582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3585"/>
            <end position="3596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="3602" mass="390917" checksum="8A9AEB751F4C1AA2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JY27</accession>
    <name>A0A8J5JY27_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tyrosine kinase-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G013696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022272">
        <property type="protein sequence ID" value="KAG7166667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JY27"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="224" mass="24540" checksum="0451150FC4DA04AD" modified="2022-05-25" version="1" fragment="single">HACFPQLLQLPPPPPAPFLSLPHTSSSSHNSSSSTTSSSGGRDLPQLTWDHLSLMGKVGTGRYGVSHHSQLTLDNGDVTAVVVKILHSGKDNTKEARVLHELAGTGGAPILYGVTTDPHAIVMQYCRGVTLSTILHHFRYQVHHRQEAYDATCFHGAGYSHLDLHAGNVIIDTSTSPYTCHLIDVGMSERIPPDDDWYEQTDWVALQDIQTRLHLHSPDDLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JY69</accession>
    <name>A0A8J5JY69_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Star-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">S-L5</name>
        <name evidence="3" type="ORF">Hamer_G011946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7166017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JY69"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053202">
        <property type="entry name" value="EGF_Rcpt_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009:SF2">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="2">
        <location>
            <begin position="163"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="341" mass="38880" checksum="72DC1BD96AE4DEDE" modified="2022-05-25" version="1">MIRMRGMIVIGLALVLVLFMVAFTSESFSLNSFLRPAPRSPRISKVYTQDYNSVSMAADNPEVIRALREQFLVPPSTLPYNLSQPEEENPSMVGASQTRVPVPPALHFDYIFENWMNLLTVMDKNTSIASASSTFAEQKRKWKVISIEQKVDIIQQRNGFYVECGALDGEIRSNTLFFERKRGWNGILIEADPKNFNQMTEKHRKAYMSSSCLAPTTHPTTQDNQGHILGKQQEHPSSSGSDVGDIVEVQCFPLYSYMVALNVTTIDYFSLDVEGAEFAVLKTIPWDKVDITTLSVEFIHDPEGKDAIQDYMKERGYYVHSEVRHYNWLANDFIFVKYSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0E2</accession>
    <name>A0A8J5K0E2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027180">
        <property type="protein sequence ID" value="KAG7162729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0E2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="368" mass="40199" checksum="FD3E5EFE3B411A58" modified="2022-05-25" version="1" fragment="single">QHSHHKLNPQKKSPRAAEARSGRRTRRTTVDRRSGDGSASAALRRETIVENNLRSFNGKRIEMRSGECIRRENNAATRVEYSYATLGHVRFHLLKLGGFVWVAWDPEGIGRRSRPAVAVREIGRTGFHVAETKERHLPAEPQPAIKGTLGFDAHGPSARLLRRNKSSRLKSPLLPGVLIGIILRRSASTETEASLDRVSGGVGFGPRPLAVIVEGIVRNAVRRDVSSKFRSGLLVAGRAGGRRYDVPGGVVVVVVGHPTGVRNVIFVRTGDSTDPGRGRRSNRGCGGARRYESETARTVGARERSGRRHSGTEDEDARPLRTKTPVDARGRCSGTREERHTPECGKTLVNAEGDTHQCRAGAIVLKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0H6</accession>
    <name>A0A8J5K0H6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="93"/>
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            <end position="234"/>
        </location>
    </feature>
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            <end position="335"/>
        </location>
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            <end position="403"/>
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            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="560"/>
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            <end position="196"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1081" mass="117869" checksum="A5E02D69C6EEEFC1" modified="2022-05-25" version="1"> </sequence>
</entry>
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        </recommendedName>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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            <taxon>Nephropoidea</taxon>
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            <taxon>Homarus</taxon>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
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    </feature>
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            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7167296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="87431" checksum="CE3BCE2655D62E3A" modified="2022-05-25" version="1"> </sequence>
</entry>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Romanova D.Y."/>
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                <person name="Greenwood S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="domain" description="PID" evidence="3">
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    </feature>
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        <source>
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        <source>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022611">
        <property type="protein sequence ID" value="KAG7166399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010021433">
        <property type="protein sequence ID" value="KAG7167607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K117"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="203" mass="23594" checksum="280BA35647EA2935" modified="2022-05-25" version="1">MYVRFWHEAPMAVRAPFNDLQLMKVLKEYPHEKVAHAAQAAISRHLWYLSEHLIGLSLFDDRIDTETKKNMVQNFQCPKKQDFSRRIVLSDETPISNAASFVTERTLDIFDVLTLDGKERAQLFLSKDPKTWKDDEVFITMRDRAINMKVVNDSAERAIALIERYNESITQNEDQKQYLLQVVAAHRKKLSTASKAAMMKGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2Z1</accession>
    <name>A0A8J5K2Z1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Hamer_G005633</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022531">
        <property type="protein sequence ID" value="KAG7166518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2Z1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF12">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="594"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7166518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="618" mass="69880" checksum="7802C814AC854745" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4E1</accession>
    <name>A0A8J5K4E1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Collagen alpha-2(IV) chain-like 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Col4a2-L14</name>
        <name evidence="2" type="ORF">Hamer_G031290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014341">
        <property type="protein sequence ID" value="KAG7170402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4E1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="475" mass="50911" checksum="47243DC0EEA2BE39" modified="2022-05-25" version="1" fragment="single">MTHLSRGQSSTSDQRGAPVREANQNVSQCQEAGAKISRNTEQQQEQEQGAAAAAVVMGVLWVVLQEAPVQQAGRYVKGTGPELLPEEDVVRLKVAQWTVGFLKLRAGMLGNSEGGVEVLQHHTQPTVPQHHTQPTVLTPHSPQCPNTTHPAQYPNTTQPTVPTTPPSPQCPNTTPSHSAPTHTPSPQYPNYTSPQCPNTTQSTVPQHHTQSTVPQHHTQPTVPQHHTQPTVPQHHTQPTVPQHHTQPTVSQHHTEPTVPQHHTQSHSTHSILTNWHGHLNTTHSPQCLLTPHSSPQDQHHTQLTGAPSTSNPDHSAPTPHPAHSAPTPHPAHSAPTPHPAHSATTPHPCPNTTTSSPQCPDITIPSPQCPNTTTPNPQCPNTTTPNPQCPDTTTPNPQCPDTTTTPTHSAPNFTLSPQWPTTTPSPQCTSTTRSPQCPNTTPSPQSPTTTPSHSAPTPHLGHIAPLQHLTHSAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4E3</accession>
    <name>A0A8J5K4E3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Low-density lipoprotein receptor-related protein 1-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Lrp1-L8</name>
        <name evidence="4" type="ORF">Hamer_G010144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4E3"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035207655" evidence="3">
        <location>
            <begin position="21"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7167756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="324" mass="37156" checksum="29004BD756B75800" modified="2022-05-25" version="1">MMIHLFKVLLLLAFCSVVLASLCEESEQIQCKESNSRCTRIRYICDGDNDCGDNSDENSSLCKLWKNRDCDRNYVKCHRFGSSSCIPIEEYCQRSDPPCEGDLDPRICQMLRNEKLQNPEDIIMPTIREDVFKGNDLSETEEMAVEFEDLTAHTFVHPDCPHLYTKVGDSCLSIFFPGNVTWGEARSFCHTIKGELYSFDNDVTKYSALVNHLKEHKLTTDFWIGGRMENITEGWKFVSDISMELGSPYWAVRHQTQCSPRSTENEHLNTTRLANNGYCYSSLQAPENPPIGHCAAITYNNYYYVSDEHCLDRKAPLCIVNKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K526</accession>
    <name>A0A8J5K526_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G010119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K526"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="153" mass="17374" checksum="84E9C095F7262910" modified="2022-05-25" version="1" fragment="single">VPFLVPTRVGGTRWLPHVLQALEHLLKSYKAIVLHMQQIQNSDDPSYHKDTSRKAKNYLLLYLHLLLDVVRCLGGLSELFGQSNISAILNETQTAVDVLNKYLTWPGSSLRRIMEGDTTMFQGEKLSGRSNTFKTARRDMLTSPISSLKQKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K565</accession>
    <name>A0A8J5K565_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin-I-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Ccni-L</name>
        <name evidence="4" type="ORF">Hamer_G024343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016225">
        <property type="protein sequence ID" value="KAG7169512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K565"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000006">
        <property type="entry name" value="Cyclin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7169512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="463" mass="52212" checksum="02FFA84CD5D12B12" modified="2022-05-25" version="1">MLQGGEVDVGARNGEVQWLREACGRLGWASETRFIAAALLDRLLHRVRIPPRYLHAVAAAAVFLAAKIHEEDENVPATIEVVELGGMKCSHRELLRMERVLLDKLSWHLQSTSALDFLQVLHALAIVTAPKHQQSNRSGSPTRQLSYLTERLWRVVCSSRSGSVRPSLLSLALLSIELDASTPEPGLMLWLQALTQVGDDELASARELVQELLGEEPYQMPQVPHNTSPKNTQHVPPSRPNKRKVAQSLEPEDDVYVDIKKLYAYEKIRNTTVTPVKDPSYSQEELDETYIDIRHLYSSPAPVHDDSLPSTQVSSSKTPNTKKNNSSKKKKKKMKPTFKAKASVRSSLKQALKIPCKISLIATKKIFEEPCEEDEEEEDIDMEYEDNSQDWEGPLVEPVGLLKSPVFSPTSPEFPDIRHLVVKKEDMCWHQQAQEVAEQVYRPLTYAQVLRLHLTPFTRALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5F5</accession>
    <name>A0A8J5K5F5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021981">
        <property type="protein sequence ID" value="KAG7166903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5F5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="349" mass="36637" checksum="5855FF08ADCBAAD8" modified="2022-05-25" version="1" fragment="single">LPLPGVGPPQVWDLPPSVGPPTDVDLSQGVGPTTRLKPPRVEDLFQVWTSPGGDLQQVWDLQQVWDLFQVWSSPGVGPPTGVGPPLVWDLPWCGTSNRCGTSSRCECTSRVRDLPCVGPPQGVRPPRVEDLFQVWDLPWCGTSSRCSTSPVEDLPAVGPHPGVDLTGTSSQMWDLSQVWDLPWCGTSPGVGPPPGVRTPPGVGPPTGVGPPTGVGPLPGETSPGVGPPTGVGPPVYRTSPNDLPERKTSRVEGLFQVWDLLQVWDLPGVGPPPGVGPPGCRTPLYGASSVYKTPSPVLDLLWVLDLPGWGPPPCIRPPQDVRPPPGVGPSPCIGSPPHKVPPGIGPLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6F8</accession>
    <name>A0A8J5K6F8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Linear gramicidin synthase subunit A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lgrA-L</name>
        <name evidence="5" type="ORF">Hamer_G018341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7167920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6F8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="885"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="460"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="704"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="557"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="630"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="705"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7167920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1112" mass="120328" checksum="C80B24866F0FA660" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KA07</accession>
    <name>A0A8J5KA07_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KA07"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="198" mass="22338" checksum="73A878CCDB00B11F" modified="2022-05-25" version="1" fragment="single">TFSDVPQRNLKLVVTEHYLHNVKDLPTPVNQKEEEELVDNPTPSTSQAPPPSHEVLSTSLPSRRERREWNKRQELERALGEGNQARISQLSIAETSIANKELSDDPWEITTTTPASPQEDVKTTTMDPELQKAIEKKKKIELDKIQTEAAKFKKRMFKNLESNNVDNLDDCTQQMSTVSAIIGDGDTIDLNGRDMAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KE94</accession>
    <name>A0A8J5KE94_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G013541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KE94"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="680" mass="73042" checksum="24402DD283B0B271" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KGP6</accession>
    <name>A0A8J5KGP6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013474">
        <property type="protein sequence ID" value="KAG7170818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KGP6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="574" mass="62541" checksum="AE4FE84B3F840C36" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJD1</accession>
    <name>A0A8J5MJD1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E2 NEDD8-conjugating enzyme</fullName>
            <ecNumber evidence="7">2.3.2.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">UBE2F-L</name>
        <name evidence="12" type="ORF">Hamer_G009292</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="7"/>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJD1"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000033">
        <property type="entry name" value="NEDD8-conjugating enzyme UBE2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="11">
        <location>
            <begin position="26"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7153638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="180" mass="20589" checksum="B8F2248669AD21F5" modified="2022-05-25" version="1">MITLTKKLKSSKGGGLPDPPKKRISIRDQLLVKEVSEMESNLPEGCAAKFDDPDTLHSFHLIVTPPEGYWSGGVFAFSINVPEEYNIAPPLVRCETKLWHPNISEEGEICLSLLRQNSIDGLGWAPTRRLKDVVWGLSSLFMDLLNFDDPLNIEAAEHYQRDKESFRRKVREYIDKYTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJR0</accession>
    <name>A0A8J5MJR0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cleavage stimulation factor subunit 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Cstf2-L</name>
        <name evidence="7" type="ORF">Hamer_G009455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJR0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.70:FF:000001">
        <property type="entry name" value="Cleavage stimulation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.630:FF:000001">
        <property type="entry name" value="Cleavage stimulation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7153772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="479" mass="53078" checksum="D2C09E6D664F99AF" modified="2022-05-25" version="1">MIGNIPYEATEEKLRDIFSQAGPVLSFKLMYDRESGKPKGYGFCEYKDQETALSAMRNLNGYEIGGRPLRLMMGPVVESPYGPDVEPNKAPEAISNAVASLPPEQMYELMRQMKLCVRNNPSEARTMLMNNPQLAYALLQAQVVMRIIDPKTAVQILHGGREAVEPLMPTGTVPPPTSIPPPTSAPPTLNGGLPVPTSGPPPPSNLPTRYPPPMTGGPGNFQGPPPGPPPTRGPPFPVSGDFDMRQLGGAPRGPPPQGNDQDMRLPPPGMTGPPPPHDNYGGQHHDFDSRYPRDPRSDFDQRDQRTEQRDQRFREPPPSREPRENFNRSDPRDTRERDRESRSYRDTRDNRDQRSSETREQRDNRDPRAGDRDYRNNPPSDARDPRGARPTFPQDKDFRSSGNPPPPPIGGPSQPPPRGVPPPATAPAALPASLAGQDQEKASLIMQVLQLSDEQIKMLPPEQRASILQLKEQIQRSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJX8</accession>
    <name>A0A8J5MJX8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044763">
        <property type="protein sequence ID" value="KAG7154238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJX8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="128" mass="13739" checksum="0760241ED774A0F6" modified="2022-05-25" version="1">MTATHRYTPPDLSWLPPLATPPAGSVMTATHCYTPAGSVMTATTATPQAGSVMTATHPRYTPSWICHDCHHSLHPQLDLSRAPLTATHPAGSVMTHSLVTPLLDLSWLPLTRYTLAGSVMTHSLLLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKF5</accession>
    <name>A0A8J5MKF5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Gamma-butyrobetaine dioxygenase-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Bbox1-L2</name>
        <name evidence="13" type="ORF">Hamer_G015061</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKF5"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF33">
        <property type="entry name" value="GAMMA-BUTYROBETAINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="12">
        <location>
            <begin position="90"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="11">
        <location>
            <begin position="196"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7154699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="456" mass="51854" checksum="064CD4655C87FA69" modified="2022-05-25" version="1">MKRPSISEVCEWVLKSWCDIKTKVIVKSFKKCGISNAMDGTEDNLLYKTDSSDDSELGDESNSAKKSWEDQGVRRVTEAPAVTVTHASVNHKTAMLEVKWTDGETDVFPYVWLRDNCQCPSCFHAASNSRIHLMGEFDLNTQPHTAQVLEEGEQVEVVWSDGHSGTYSAAWLHPRAFNATRRLAQAPKFRLGRRYWGAELLKNLPRASFQELLTDDKALLTWLQQLEVLGFVLVSGAPAEPGHVRSLAERVGFIKKTHYGNVAYLDSPLQLHADLPYYEYKPGVQFIHCIVQYEGKGGESQITDAVHVAQELKRLHPEKFRILTQTPVDWFDVGTDEYGAFYKVLQIPMICTDVSGEIYRINMSQPQRDSFFSIPANEVAGWYDAMITYHHLLSSPNYCLQFKMVPGMILTFDNMRIVHGRTSYMSGSGERHVEGCYIDWDEVKSRRRVLEVQNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKP3</accession>
    <name>A0A8J5MKP3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD repeat-containing protein 37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Wdr37-L</name>
        <name evidence="8" type="ORF">Hamer_G021951</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043253">
        <property type="protein sequence ID" value="KAG7154941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKP3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="148"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="288"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7154941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="482" mass="53384" checksum="E7ED0DAD2DAC33C6" modified="2022-05-25" version="1">MPQDGLGSKSGGKKRSGGVPRVRSHTDAELQYYRDQDHDNLLPPPFRARLQDLFIQIEKEFEALYAENFALQDKIDGLTERLERESVIGERPGGNDENDGASTKGLKSKSGGQSSQKVKAANKLRVQTSKIVSSFKNDTVSCRMVREYVGHRDGVWDVAVSRVGTPVIATASADQTACVWGIDGGRNLLQYTGHCGSVNSVKFHPTQDLILTASGDHTAHVWQAAITPDQLQLNMQNQKQDYLIVQRVHSSEDEVDGSDREDEDDGGMMCVRGDGGGAATLRTPLKELTGHTSVVIAADWLPGGDQAITAAWDRTANLYDTLTGELLSQLIGHDQELTHCCSHPTQRLVVTASKDTTFRLWDFREPIHSVSVFQGHTEYVWDVKNMRSPLATIRLDSPVNRLAVSPTNVIAIPHDNRHVRLYDLTGNRLARLPRSNRQCHRRMVCSVAWGEDSLGARCNLFTAGFDRVVYGWSIHSFKEGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMS2</accession>
    <name>A0A8J5MMS2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037686">
        <property type="protein sequence ID" value="KAG7157253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMS2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="217" mass="24295" checksum="D5273F84C4EA0794" modified="2022-05-25" version="1" fragment="single">MTLAQKTKEDEKQGMNPPFSSSSESEEQVNSSASECSPPKKSKPGKPRAKNIMSPVLAKALDRTKISDRDAVHLIAAAAQSLGHNVEDIAVNRKTIRQSRMKLRVQSFKSAKEQFILNLDPTIPLVVHWDGKLLPETAGGKETYDRLPIIVSYEENEQLLNLSPSLWQTNAGYCKAQKKLKTMKVVNDVAERGVALIQDYIHVITKDEEQRQFLLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPQ1</accession>
    <name>A0A8J5MPQ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPQ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="179" mass="20050" checksum="A17A5A370E272F14" modified="2022-05-25" version="1">MVHVHIIQPDNATLDLTSAVKSEEAPLPGIPRPPPTHLLPGQQSRPGRMKGGGLPHFLSSSRCQIHFYPEPSCSRGIWVLKPGEIHILCPQYGVWKCCVSPGGWRGGRARDWEPVDIECEVKGQPGKTTIYPPWRRRQNQHVITPTLDSLTREPRYPITMAEESGGDGDLWQLLQVRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQ70</accession>
    <name>A0A8J5MQ70_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin-related protein 2/3 complex subunit 1A-like 14</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Actin-related protein 2/3 complex subunit 1A-like 18</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 1A-like 19</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Actin-related protein 2/3 complex subunit 1A-like 29</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit 1A-like 4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Actin-related protein 2/3 complex subunit 1A-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Arpc1a-L19</name>
        <name evidence="8" type="synonym">Arpc1a-L14</name>
        <name evidence="9" type="synonym">Arpc1a-L18</name>
        <name evidence="10" type="synonym">Arpc1a-L29</name>
        <name evidence="7" type="synonym">Arpc1a-L4</name>
        <name evidence="11" type="synonym">Arpc1a-L6</name>
        <name evidence="7" type="ORF">Hamer_G026904</name>
        <name evidence="11" type="ORF">Hamer_G027689</name>
        <name evidence="8" type="ORF">Hamer_G028797</name>
        <name evidence="9" type="ORF">Hamer_G029013</name>
        <name evidence="6" type="ORF">Hamer_G029273</name>
        <name evidence="10" type="ORF">Hamer_G032036</name>
    </gene>
    <organism evidence="6 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032559">
        <property type="protein sequence ID" value="KAG7159728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010031629">
        <property type="protein sequence ID" value="KAG7160231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010028985">
        <property type="protein sequence ID" value="KAG7161524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010021968">
        <property type="protein sequence ID" value="KAG7166906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010016451">
        <property type="protein sequence ID" value="KAG7169468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010006505">
        <property type="protein sequence ID" value="KAG7174871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQ70"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7159728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7160231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7161524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7166906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7169468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7174871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="88" mass="9689" checksum="AC18E2F8FBDEE536" modified="2022-05-25" version="1" fragment="single">MALFTSRGPVAEVFRFGLVPIACRARNEDRSQVALSLNNNEVNIYGRAASEWKLQETLQGHDLRVTGIDWAPSTNRIVTCGAVSLLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR23</accession>
    <name>A0A8J5MR23_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Oplophorus-luciferin 2-monooxygenase non-catalytic subunit-like 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Lucb-L17</name>
        <name evidence="2" type="ORF">Hamer_G012769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR23"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035236498" evidence="1">
        <location>
            <begin position="22"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="100" mass="10708" checksum="6BC87C8DE43CD84B" modified="2022-05-25" version="1">MNKMIQVIQVLLAIIIVGCLAGCPPPEDLGPCQCHDDPDGAPALQCRGVTGWEEVATIFTDLGLDYISSVDIIYSPDLTDLPPSAFADVLIDAIRFYNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRJ8</accession>
    <name>A0A8J5MRJ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030877">
        <property type="protein sequence ID" value="KAG7160732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRJ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="69" mass="7492" checksum="B0F379F3B14D6D38" modified="2022-05-25" version="1">MVEQTTRAMTSSPVVCLIGETEALHFTPHSESFPHSYTSVSPSFTPTPHSESFPHSYTSVSPSLTPTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTW4</accession>
    <name>A0A8J5MTW4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CCR4-NOT transcription complex subunit 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Cnot10-L</name>
        <name evidence="1" type="ORF">Hamer_G025767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026515">
        <property type="protein sequence ID" value="KAG7162904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTW4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="124" mass="13846" checksum="EF865EEB12A48BE7" modified="2022-05-25" version="1">MTSVMPEMYSAGPSSPLRGTEVVSLRVSALACSAYVSLCLFDYATALRPQRPYWPLTPRFLVFTSHVDVMKNIVKKKHPVDLITVRSPYQGSTTLYLRDKCSVPGPGRVWCVVEDSLVAHYHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUY2</accession>
    <name>A0A8J5MUY2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of G-protein signaling 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Rgs2-L</name>
        <name evidence="2" type="ORF">Hamer_G022654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025116">
        <property type="protein sequence ID" value="KAG7164556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUY2"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000001">
        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF259">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="1">
        <location>
            <begin position="67"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="194" mass="22089" checksum="53DF4B4F5F75A078" modified="2022-05-25" version="1">MIATDLRRESLKATKNVLGSLNSAIADSLAHGKRSDMRLRLGWLRRRGEAQVSVRPQPEEVQGWAESFHNLMASKYGQALFKAFLQREFSEENVEFWLAVEDFRKTRAAKMTSKATKIHSDYVAVQSPKEINLDPGTRAQIAKSLDCPDKYIFDAAQKRVQALMESDAYLRFLQSELYKELLHPESSPSNPETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUY3</accession>
    <name>A0A8J5MUY3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Tigger transposable element-derived protein 1-like 328</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TIGD1-L328</name>
        <name evidence="2" type="ORF">Hamer_G003437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUY3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="98" mass="11037" checksum="D54D5BBAA0040542" modified="2022-05-25" version="1" fragment="single">DAKPRELPTSVLSSILREVDKQLQILEDNDYNAERSRIAVRGKKEAKQQTLDVFLKSTPKKQTEDTEPQPSTSGIRHFFLPSHATKTAPDDDTDDDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWJ2</accession>
    <name>A0A8J5MWJ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Neuronal acetylcholine receptor subunit alpha-9-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Chrna9-L1</name>
        <name evidence="20" type="ORF">Hamer_G005457</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Synaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWJ2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="15"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="203"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="341"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="398"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG7167120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="486" mass="56216" checksum="11A33C9FF6E46A4A" modified="2022-05-25" version="1">MTNTSATITNKSAPQDEKNQILTTNCWLTQIWTDAHLTWNSSDFGGIQVIRVPFQRVWKPDIILYNNTSDPVRVHLLLSPQRRRPALGGDHQHHVIVTSKGVTGSHLLQLSFLPDMNVEYFPFDIQSCKMMWASWTYDGYQLDLVKQMDEGDMSNYKSNGEFDLVEFTAAKNITYYSCCPEPYPDITFTIKLRRRPMFYVFNLILPCVLINGIALLVFYVPSESGEKVTLGISALLSMTVFLMTIRESLPPTEKTPLISMSVVTLNIHHRGVRGTEVPRLVKMVVLGWLSKLVFLHFEPPVLPPDDKNVHLNDLRPDRGMRLDSISVEKFHMTELENVDHFSVSPRFNPRRHTTPNNDPTPTPTPTITATQTSDFEQQFMRVLNKVYQTIEKNEMRLGEQDRKEATRVEWQQGREEEEEEEEEEEEEEKEEEEEEEEEEEEERYGGASVRQVPAGVFPVVDGDRHYHHPLLLTTRAMTSLRRHLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY43</accession>
    <name>A0A8J5MY43_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 23 member 1-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Slc23a1-L5</name>
        <name evidence="8" type="ORF">Hamer_G017194</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY43"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037981">
        <property type="entry name" value="NCS2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7167284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="586" mass="63249" checksum="28D115FBFEE90D11" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYV7</accession>
    <name>A0A8J5MYV7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA repair and recombination protein RAD54-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RAD54-L4</name>
        <name evidence="3" type="ORF">Hamer_G027127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020450">
        <property type="protein sequence ID" value="KAG7168244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYV7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="155"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7168244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="236" mass="25783" checksum="0C83A6475D19541B" modified="2022-05-25" version="1">MRRSHAPSQLLKRKNDCGFTIGPKVAVSQSDSKRQKVAEKAGPGLLVSPYRAPLVPIVNTPTGQTSSHEDLIRKILAKPFKIPIPNYVSRGSRCLGIRRNGVRRPLHDPDEPGALVLYSLAVLSAQEKLTANLCVLCDLAMPKRPAAKTPSKVTKRSRVAVTLDMKLDIVKRHEHGEGTSVIGRVHGLAPSTVHSIVKSADKIKEMARSATPLTATKMTRFRDAEIEYGADVENMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZ85</accession>
    <name>A0A8J5MZ85_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G011565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZ85"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="35" mass="3853" checksum="29AD911DD5086B12" modified="2022-05-25" version="1">MKAIMLEFGVFSLSDSSHHHHPTGCLALTEVSNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZP8</accession>
    <name>A0A8J5MZP8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL21</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Rpl21-L</name>
        <name evidence="6" type="ORF">Hamer_G019763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014926">
        <property type="protein sequence ID" value="KAG7169943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZP8"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7169943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="160" mass="18303" checksum="F2A1AD295A553ACB" modified="2022-05-25" version="1">MTNPKGLRRGTRNMFARPFKKNGVEHLSTFLRVYKVGDIVDLKGNGAFQKGLIHKCYHGKTGRVFNVTQHAVGVIVNKRVKGKILAKRLNVRVEHLSHSRCREDFKKRVKENDRIKHEAKSKGIKAVCKRQPAQPRPAHKVNISENTPEFLTPLPYEFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZQ6</accession>
    <name>A0A8J5MZQ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017007">
        <property type="protein sequence ID" value="KAG7169386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZQ6"/>
    <dbReference type="OrthoDB" id="6366805at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="281" mass="30424" checksum="54AD4C6D753B4B1A" modified="2022-05-25" version="1">MATPGEHTDEGAASLPLLCPKLGEMLSRGRGLVTTSTYGETLQTHTMVSTSSSYQSSASLTTEPVSILGKGRHHSSSSISSSSSPKHSVKFTEPEGAVYRDRAPESPRFKTVGQEKIKYQENFKFKVHDGSTSMHRNAGHGIGSIPEKSAYSVSESSNYRYTESSKLVGTSYRCPDSPRNKTRMITRTPDRNSIIASMELKVPSFHDLGVPSSGSSGGGLTPLLGHPESRGLTILSPHNPTPELHFSSTFTVRTRKGKTIVLPKLRIPAFHSHSHDSIFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0E0</accession>
    <name>A0A8J5N0E0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine/arginine-rich splicing factor 4-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Srsf4-L3</name>
        <name evidence="2" type="ORF">Hamer_G012285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0E0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="323" mass="34279" checksum="35CC06826EE98568" modified="2022-05-25" version="1">MLRSLSRSASKSPLRVSPGQESHESMRVNLTSCGSIPLPKVGSPSKTLGDIQSPKWSQNQSLSAKLLDINDTLIRSNESASVRSCGPQDLPRLPQNGRHTGGPSTNKSPVPHSSGVAAVSPAHSRYSRSSSRGRSSSRSSRSSRSRSSSRSHSPSLRSRSPSPRSRSPTSRLAPLVLGLGHIHIQGPIPHNQGQGHGHIPDPGHIPGQDQDGQGQDLGLGHMAIIVDQSQDPVQGRDLDPDHCPSHAGEDPHHSWTKEGSPVQGNDLFPITGQRPLPPHHPPSHLGGRAVAVAAELVADRGAVLVLPPTVGNQLERFTCLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1Z1</accession>
    <name>A0A8J5N1Z1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011977">
        <property type="protein sequence ID" value="KAG7171694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1Z1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035268584" evidence="1">
        <location>
            <begin position="28"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="78" mass="8568" checksum="78813E51D71A838A" modified="2022-05-25" version="1" fragment="single">GRGQGVGVWYWCWRPWLVGVGVPLALRVDPGASLHQRLESAKTLLRETPLFDGFNFTAELKKLVRGPGPLGPILTCPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N403</accession>
    <name>A0A8J5N403_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cc8K15.2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N403"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="65314" checksum="D83DB8125D626F59" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N503</accession>
    <name>A0A8J5N503_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tigger transposable element-derived protein 1-like 92</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TIGD1-L92</name>
        <name evidence="3" type="ORF">Hamer_G018649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009960">
        <property type="protein sequence ID" value="KAG7173367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N503"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="131"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7173367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="386" mass="43183" checksum="DD9ABA6ADBE7E7CD" modified="2022-05-25" version="1">MNITKSTGASTIKYCHNQVLLKTEKLLVSYLIRQAQRNMVVDTRSVKEYARELYAAVSRKMGIAEPKPFNASSGNKITNINIGGEEAGADRVAAREFPPFLCEIMEEGQYTDDQTFVVKNASKCRGRKLQKEHITALFTTNASGTCKLKLSVIHTARKTHAYKSMDMTKLNVHWLTACKAWMFSTLSLSWFDDCFVPDVKKFCEQQNVPFKILLLLDNAPGHSPLLLDRHPNVKVVFLSPNTTSLIQPMDQELICNVKAAFSAKKLKLLNGYTNTKDELRNLGDTDSKSDDDEEQQLAEQEVLVKHFWRKFNVKKAVDFLSQSVTVAVDLAREAAQSVTAAGFSETTSDDILEVIRDPDVTADEMLDDDDVSEEAGGASSQEERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5T1</accession>
    <name>A0A8J5N5T1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inorganic phosphate cotransporter-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Pht-L8</name>
        <name evidence="8" type="ORF">Hamer_G020041</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008712">
        <property type="protein sequence ID" value="KAG7173893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5T1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000532">
        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="58"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7173893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="505" mass="55953" checksum="3E98599BC3B738C6" modified="2022-05-25" version="1" fragment="single">MTRVDLSLVSTTGEVIGEHKPSEHVEPQEPHPKSLLLDPEAHQPHPLQEGGCWQVRYTFAILGLVGIALMYAMRVVLSIAIVAMVGSRSHHHHSNTTTTTTEELANVCPNPDTNATNKDNLLEGEFDWDETMQGVILGSFFWGYIVTNIPGGRAAEYLGGKMVFGLGIVLSAILTILTPISARSSTPLLIAVRVLGGVVQGVVFPAINSMLATWIPPAERSRYNTIVYSGFPLGTVVCLPVGGWLCSSGFLDGWPAPFYLFGGLGLVWGVAWFLLIHDRPERHPRISAKELAHIQSFQQDIKRAEVVALPWKDIFFSLPFWGLMAGALGFDFGFYTLLTELPTYLKNIQHFDMSENGLMSSLPFLAMWLWGYLWGSIMDRLTAAHKLSILSIRRLSMALAMYGPMLGLVVMCFVNCNTTLAMVVLCVAVGQTLSAWRMVFLITVAMYLVTNTLYIIFISNNVQHWNEPKTNKEGVEYNTSLETRVALVPDDTKDTLVLESDREEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N618</accession>
    <name>A0A8J5N618_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1</fullName>
            <ecNumber evidence="9">2.1.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">TAR RNA-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TARBP1-L2</name>
        <name evidence="13" type="ORF">Hamer_G018903</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20077"/>
            <dbReference type="Rhea" id="RHEA-COMP:10190"/>
            <dbReference type="Rhea" id="RHEA-COMP:10192"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="EC" id="2.1.1.34"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:20078"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010009009">
        <property type="protein sequence ID" value="KAG7173757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N618"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141100">
        <property type="term" value="F:tRNA (guanine(18)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000010">
        <property type="entry name" value="probable methyltransferase TARBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="12">
        <location>
            <begin position="196"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7173757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="349" mass="39354" checksum="CD57C6F1E2AB8328" modified="2022-05-25" version="1">MWVLEFYLTPSSSSASLALYWVSLRKMWHHCEAKQVTAVLRRYEPVQQCLQFVVEHGNSARNTLNMLNDFYFKVFHPIQHYTLETILHDLPCLSLLADDEWLTIDFFLGVMDTQDLPLCGDLPLHNADQVLAESLPAPWVIKAAGDTSPVEDKDGPSESTNNVQRKITPWKSMVPEITASLDLPEQPETHPSRGALIVVASLIDKPPNLGGLCRTCEVFSVKEYIVPSLSILEDPTFNSLSQTAQQWVPMKEVKPDCLAHYLRTLQNEGYTLVAAEQTANSIKLSEYSFPERTVVILGNEREGIPCELLQLLDVCVEIPQTGIIRSLNVHVSGALFIWEYTRQHLKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6P7</accession>
    <name>A0A8J5N6P7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6P7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035258400" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13278" checksum="65A18C4F2055FAEC" modified="2022-05-25" version="1">MVNTMMSVSILWIRILLWPCCASCDSCSNMQLSASSCLHGIDVRRSSSPGLPKTPSPSVMTNCLPSLPNYLRTASNRNLKSSVLLQSMQMKLPISLYGCCSYHSPFPCFVLAMHFRESLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6T0</accession>
    <name>A0A8J5N6T0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007069">
        <property type="protein sequence ID" value="KAG7174741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6T0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="73" mass="7898" checksum="9A1BF9DBAA40107A" modified="2022-05-25" version="1">MGRIGVFGMVGGSDGGRGSGYSATEMGAKGQATKNKRDVLILKEIGCMNLFGMWCIGCRCCREKASEVTMWWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N752</accession>
    <name>A0A8J5N752_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL35m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L35, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mRpL35-L</name>
        <name evidence="9" type="ORF">Hamer_G003273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N752"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_bL35-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_bL35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019338">
        <property type="entry name" value="Ribosomal_bL35m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15909">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15909:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="L35p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7174334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="177" mass="19806" checksum="74E83B9B7D617AE5" modified="2022-05-25" version="1">MLRTVSRLSTYSSAILASSGPAGCPKNVLKPTILNGKRITLPSRPVLYQLSTGASPVYTFTPSMVSGLTTKMSDWILKSEPSLLAAPAPATTTQTRSVVKWSLQKGKRKSVKAVLKRFKRFDWGGRSIWIHARSGAKKRMWKKSPSQRRRCKTHVFCNATQSQLLDKMVRILPFPCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8K8</accession>
    <name>A0A8J5N8K8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ras-related protein Rab-11B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Rab11b-L</name>
        <name evidence="1" type="ORF">Hamer_G009933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8K8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="97" mass="10887" checksum="CA9E6F4C7D497CD1" modified="2022-05-25" version="1">MLVGNKSDLRHLRSVPTEEAKAFAEKEGLSFIETSALDSTNVETAFHNILTEIYRIVSQKQIRDPHDHDDSPTADVKAIHVEPTVNAESVRKQCCQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8L3</accession>
    <name>A0A8J5N8L3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AKT-interacting protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">AKTIP-L</name>
        <name evidence="3" type="ORF">Hamer_G009931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8L3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="58"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="281" mass="31713" checksum="D50C8A7C6F7745C5" modified="2022-05-25" version="1" fragment="single">LSDSGGPTDGGGGGNVGSDGNVVGSSGSSSSLTRSGSTRGSLRKVLPSVPDMDQQLSMAAKMIDRRTSTPKGNHSYSPYFLEYTLLAEYNLLQKQRVSVWFGVMFLRQGIYQEGIFRFNLHIPENYPDGDTVIFETPVFHPLINPDTRELDIKRGFANKWRRNVNHLWHVLLYVRRCFYKIETSHPLNPEAAVLYDSDNEMFLLRVRECVDKSKVTIYETTVTNDPHALVFSPYQPAIHDPVREELKRERNEPESTLKEDNGNGLSWVKPGTLQIFSRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9B3</accession>
    <name>A0A8J5N9B3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9B3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="340" mass="36478" checksum="431FA30648C90AA7" modified="2022-05-25" version="1" fragment="single">HGEASQVNVVESRSVTDELRLLESQIKLKEAEAIARRVGIRQAEAEAKAKEAEAKAKEEELDAYCGKPGHKAEDCWTRLQLNTGKPAMIVTEETNTSPVEVMADLSKADNMPIGLVFTKGVVRESAVSVLASRDFDLFQESFAKDPDVGTFSPFLSQGTVEVDGVETPVTILRDSGCLQTLIKESVVAARKTDKYVVLGSRCSSFGIANVAFVHELLVAGVDLILGNDLAGGQMGNVTPPPVLREKPESTAELQQLEDDMPGVSPLCAVTRSMSMTKDHNATPVVDDSLSLEGLFANPIASQDISSAVNAVTGRVALIAAQEQDDSLRLLFDSGPTTRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9F0</accession>
    <name>A0A8J5N9F0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hillarin-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Hil-L1</name>
        <name evidence="7" type="ORF">Hamer_G001167</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9F0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="628"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7175159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="777" mass="85900" checksum="20FCBA5CF4353757" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9U9</accession>
    <name>A0A8J5N9U9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">La-related protein Larp4B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Larp4B-L</name>
        <name evidence="6" type="ORF">Hamer_G015405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12430">
        <property type="entry name" value="RRM_LARP4_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058699">
        <property type="entry name" value="RRM_LARP4/4B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF131">
        <property type="entry name" value="LA-RELATED PROTEIN LARP4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26088">
        <property type="entry name" value="RRM_LARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="5">
        <location>
            <begin position="309"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="488"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="587"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="746"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="656"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="746"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="796"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="885"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1014"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1104"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1193"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1253"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1277"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1310"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1346"/>
            <end position="1357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7176600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1357" mass="148689" checksum="104833A021446DE3" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA63</accession>
    <name>A0A8J5NA63_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein acetyllysine N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Sirt6-L</name>
        <name evidence="10" type="ORF">Hamer_G009934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2919105at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:histone H3K9 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01410">
        <property type="entry name" value="SIRT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000038">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF12">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7175897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="438" mass="49290" checksum="99C78804D05E8205" modified="2022-05-25" version="1">MSCNYAEGLSKYENKGKLGLPEKFDPPEEIERKVQVLAEWIKESTHTVFHTGAGISTSAGIPDFRGPKGVWTLEKEGLKPDINISWDDARPTLTHMAIVALERNGYVQYVVTQNIDGLHLRSGLQRQKLAELHGDMFVDKCNYCHRQFVRNTAATTVGQKSEGKPCPGKRGNGRRCRGKLHDNVLDWEDGLPDADLDLAISHACAADLSICLGTTLQIVPSGNIPVDTKKRGGKLVICNLQPTKQDRHADLIINAYVDNVMKHLLEFLDIPLLQYDPNVDPMKLTQKMLHEYRKTHPEDNDQNGKLVSSNHNGFEPIEWTIPEEWVSDKELAEKVKVKKVIRNKRQSKHTTNDGDIKCSKQAKINLKSELHTDNCGSEKEERELYCSGNTVNDLNNYVKSMIKCDDSKSSWEQVGELKEEAQEIKNEHSVSKAQNGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NB22</accession>
    <name>A0A8J5NB22_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme E2 R521-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G024709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003996">
        <property type="protein sequence ID" value="KAG7176153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NB22"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUM-HD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="329"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7176153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="402" mass="44763" checksum="E6C75A951E346AAC" modified="2022-05-25" version="1" fragment="single">EEEEEEEEELEEEEEEEEEEEEEEEEEEEEEEEEKKVVGEVVGEVVEEVVKKVDGKVVEEVVEEVVKKVVGEVVGEVVEEVVKKVVGEVVGEVVEEVVKKVVRKVVEEVVEELVKKVVGEVVGEVVEEVVMKVQGEIVEEVVKKVVGEVVEEVVEEVVKKVEEEVVEEVVEEVIEEVAKKVEGEIVEEVVEEVERKVEGEVVEEVVGKVVGEVVEEVVNKVVGEVVGEVVEEVVMKVQGEIVEEVVKKVVGEVVEEVVEEVVKKVEEEVVGEVVEDSPEYGMGTTTTSTLVINVTREHDQAAVVCQAKNPTRPKSPLTNTTTLVVHYPPTVNATLGRTLKPSLLKEGDDVYFDCIVSANPEASSITWYHEVHVHLPRPAVLTWCLYIGIENYTGIIRYLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCH0</accession>
    <name>A0A8J5NCH0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Repressor of RNA polymerase III transcription MAF1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Maf1-L</name>
        <name evidence="4" type="ORF">Hamer_G000463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCH0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035294579" description="Repressor of RNA polymerase III transcription MAF1 homolog" evidence="3">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7177202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="184" mass="21263" checksum="4FFC36E34CE6B9F3" modified="2022-05-25" version="1">MGVLWLATLWQVQPWCLKECPYWPPLSSVRFVLRSSQSSGGEDSPLEDKINRKTLFYLISTLNAAFYPDYDFSNASSQEFSREPSLEWVMRAVERQMMAVARSEFISVESALWAALDSAICLREYQTSDPYSEDGCLWSFNYFFYNSRLKRIVFFTCRSVSQYCGSPHDSGLIGNSCMDFEEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ND28</accession>
    <name>A0A8J5ND28_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitogen-activated protein kinase p38a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">p38a-L</name>
        <name evidence="4" type="ORF">Hamer_G000282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ND28"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000691">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7177056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="283" mass="32604" checksum="99C2FC47C96251AA" modified="2022-05-25" version="1">MGADLNNIVKTQKLTDDHVQFLIYQVLRGLKYIHSAGIIHRDLKPSNIAVNEDCELKILDFGLARPTESEMTGYVATRWYRAPEIMLNWMHYNQTVETLDIQQLNLIMELLGTPPQEYLNRITSESVKLHLFIYCWVTLALLSDIDQLNKIMKLVGTPSQDLIDKLSSEEARNYIRSLPQMRKKDFRQVFRGANPLAVDLLEKMLELDSERRVTAVQALAHPYLAQYADPSDEPDSEPYDQSFEDMELPTEKWKELVYQEVTNFTPKPTVIAEEAEKAQSAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TCI0</accession>
    <name>A0A8J5TCI0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BUB3-interacting and GLEBS motif-containing protein ZNF207-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ZNF207-L</name>
        <name evidence="8" type="ORF">Hamer_G000858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TCI0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7171917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="196" mass="21160" checksum="C3D1DCD864A44E2E" modified="2022-05-25" version="1" fragment="single">YCNREFDDEKILIQHQKAKHFKCHICHKKLYTGPGLSIHCMQVHKETIDKVPNALPNRNNIEIEIYGMEGIPEEDLKEHERQRAGRMGPGGRRQDEEDDDDSQSSLPGQSNPPPPAVPSQGPPGPMGPMMGPNGPMMPMMGHMGPMGHMPPYMGGPGMMGGPMGPLGPMPPPGGPPANNPPSTSQPPNKPLFPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5THB1</accession>
    <name>A0A8J5THB1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5THB1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF1">
        <property type="entry name" value="TESMIN_TSO1-LIKE CXC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="122" mass="13615" checksum="2353C1CCD3B1F52A" modified="2022-05-25" version="1">MILGGLYIEMAALRMAGSWLQGSGWAETLVQADIASPGIANSFLKAAHVTRTRRGHQITAATLNILQHKAFGKYTEDAQSDGHEPLEFGVWCQQRAECCPQFQYWAIILNLELSIFMFVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TI98</accession>
    <name>A0A8J5TI98_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006389">
        <property type="protein sequence ID" value="KAG7174900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TI98"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="70" mass="7801" checksum="3B65E35FD3EF2854" modified="2022-05-25" version="1">MGSLVLIKPSPVSLLINYVSPTNNYGKRDRNWVTSIRGDAEEVAVVRASSTLACPVQWLKSFPCYFGQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJA9</accession>
    <name>A0A8J5TJA9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Chitin binding Peritrophin-A domain-containing protein 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G016990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7176026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJA9"/>
    <dbReference type="OrthoDB" id="6330787at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035243940" evidence="1">
        <location>
            <begin position="23"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="73"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7176026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="269" mass="29348" checksum="678F507D035F776C" modified="2022-05-25" version="1">MMTWSRQLLTLLTVVVGHLVDGEFICSGDGFQCSSCNTLAYCSNDKMHMEFSCPPDQWCSSPGGCFTLENEQLKECKCTSSRGFMADPFNTQKYIMCVGEGSQTNLTCPEGKAFNVKTSCCEKQPPLECNRTGFFPVLPSCTSHYSCIPDGSGGYTAAGLTKCTETDFVFDTASLECVNKTTIQVSPEPTCPSGDLVAALDSLECNAFHLCQEGTVISGPICCPVEGQVFNVDSMICEENTEQVECPSINPCDDQEYTYKCNRTQMLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TL06</accession>
    <name>A0A8J5TL06_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proton-coupled amino acid transporter-like protein pathetic-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">path-L1</name>
        <name evidence="8" type="ORF">Hamer_G015346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TL06"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="87"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7176550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="325" mass="35415" checksum="09ED1E339A3FE0E9" modified="2022-05-25" version="1">MRRAKSVTNQPHSTQSLLTVESQGQKTLLSHRQIKNEPITRPGPGVITAAVDIKEQDRWAGPTLQERDTQVGAISSVLPEGDINNASTGLLAMPEAFMNAGLWVGFAGIPIMGVICIHCMQMLLRSSKELCKRAGKSALSYEETAEAAFRLGPEGCRKWANTVRYIITTFLIITQVGFCCVYAVFIPQNLMQAIECMLPSGSSISVYGYMGIIILPILLICYIPNLKYLAPVSLMAGAVQIIGITICFYYMLRDLPHVQEELPAFAGFSTLPLYFGSAIYAFEGIGLGALICLFGLVGFVAGTITSVESIIDFFMNGQQQPSYEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J067</accession>
    <name>A0A8J5J067_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Emc3-L</name>
        <name evidence="9" type="ORF">Hamer_G010667</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J067"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7153357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="257" mass="29438" checksum="77492443AE2A0A1E" modified="2022-05-25" version="1">MAELLLDSDIRVWVFLPIVLITFLCGILRHYVSVLISTQKKVDLTQLQDSQAMIRSRMLRENGKYIPEQSFLMRRHFFNNDESGYLKTVKRASAPQPMTDPNMMVEMLKGQLTNMLPMIAIGGWINWTFSGFVTTKVPFPLTLRFKPMLQRGIELVSLDASWVSSASWYFLNVFGLRSIYTLVLGENNAADQARIMEEQMSGAAMAMPQDPKAAFKAEWEALEIAEHKWALKDVESDLLQKHEVDWMFNAQSYGNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J243</accession>
    <name>A0A8J5J243_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G009328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J243"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035290372" evidence="2">
        <location>
            <begin position="23"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7153662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="148" mass="15736" checksum="E97EA7E4183CEB55" modified="2022-05-25" version="1">MAPNWRFILLAVLLLVVSLATAANQAGGEGTKSSSKTTPGHPKPHPHPPVIHPYPHPPVVYPHPHPPVVHPHPPVVHPHPPVVHPHPHANQYLQGQFPPGRPGPHLYNSPEVFGPGGHGHGAYSLEYFGPGHGHGPGVYGVPSIEVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDA1</accession>
    <name>A0A8J5JDA1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Gamma-aminobutyric acid receptor subunit beta-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Gabrb-L9</name>
        <name evidence="17" type="ORF">Hamer_G006002</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDA1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="16">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7156282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="573" mass="65560" checksum="9CAF5A3F153FCE52" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDF1</accession>
    <name>A0A8J5JDF1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDF1"/>
    <dbReference type="OrthoDB" id="6375897at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="196" mass="21685" checksum="B003B97C9BAE3BA4" modified="2022-05-25" version="1">MVMPKGSRAQAASPVLLHSDLDMMASTPLFDDHDDTLEVVLFDTTVEYMPKSKTRTRTALNTDAHIESLKKQLLESSEQLVPVEGLFQADSAGSFGPPGLMALDHNCYQMNVELESPSEGQTTTPPCDYLLPGRLEEDSSLVSVFRALKCIEVEDAPQDSRLLSLEVRRPQHPRQISGLRHPSGYSPLSQDVTIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFU7</accession>
    <name>A0A8J5JFU7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta-1-pyrroline-5-carboxylate synthase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="2">Glutamate 5-kinase</fullName>
                <shortName evidence="2">GK</shortName>
                <ecNumber evidence="2">2.7.2.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="2">Gamma-glutamyl kinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="2">Gamma-glutamyl phosphate reductase</fullName>
                <shortName evidence="2">GPR</shortName>
                <ecNumber evidence="2">1.2.1.41</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="2">Glutamate-5-semialdehyde dehydrogenase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="2">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="5" type="primary">Aldh18a1-L</name>
        <name evidence="5" type="ORF">Hamer_G009370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-glutamate + ATP = L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="2"/>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFU7"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04256">
        <property type="entry name" value="AAK_P5CS_ProBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000032">
        <property type="entry name" value="Delta-1-pyrroline-5-carboxylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000011">
        <property type="entry name" value="Delta-1-pyrroline-5-carboxylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041744">
        <property type="entry name" value="G5K_ProBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005766">
        <property type="entry name" value="P5_carboxy_syn"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01092">
        <property type="entry name" value="P5CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036429">
        <property type="entry name" value="P5C_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="4">
        <location>
            <begin position="120"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="3">
        <location>
            <begin position="402"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7153703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="845" mass="91949" checksum="05C524E3D8C65414" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGB2</accession>
    <name>A0A8J5JGB2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037054">
        <property type="protein sequence ID" value="KAG7157647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGB2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="109" mass="11909" checksum="0A630A09A8735858" modified="2022-05-25" version="1" fragment="single">LTSLRSRAQRLTASSTTQLITRARESSDTISPDYSIPAPWESPPAIYNILKSGTSKADWNTHELRQVAERHMKAVTPHNSIVYYTDGSVESSNTKAGEAFTIKGGGMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGR0</accession>
    <name>A0A8J5JGR0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">folate gamma-glutamyl hydrolase</fullName>
            <ecNumber evidence="3 8">3.4.19.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Ggh-L</name>
        <name evidence="10" type="ORF">Hamer_G024026</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:56784"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="EC" id="3.4.19.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.9" evidence="3 8"/>
    <dbReference type="EMBL" id="JAHLQT010041911">
        <property type="protein sequence ID" value="KAG7155350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGR0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034722">
        <property type="term" value="F:gamma-glutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046900">
        <property type="term" value="P:tetrahydrofolylpolyglutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015527">
        <property type="entry name" value="Pept_C26_g-glut_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315:SF0">
        <property type="entry name" value="FOLATE GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315">
        <property type="entry name" value="PROTEASE FAMILY C26 GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51275">
        <property type="entry name" value="PEPTIDASE_C26_GGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035162684" description="folate gamma-glutamyl hydrolase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7 8">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR615527-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7155350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="365" mass="41117" checksum="E42E82080E4D6E32" modified="2022-05-25" version="1">MMGGPLQPCVLLLTLLGLCFAVTPLMEDQQQVPEIPLNLRPIIGILSQEPSRSMNRVLSHKNYTSYIAASYVKYYESAGARVVPILINQNETYYREIMESINGLVFPGGAVPITQESGYGRAGRMLYDILLEAAHLGKPTVPLFATCLGFEMLMYLSDNNTNPLTSCRAKNRADPLYLQEVLNNSAPRHVFIKHVTVSVVCVRSGSKHLAVLGWNSSQLLGEAPEDVLDTLANTNATSNFHKWCVTPETFQNSSLEKNFLLLSTSEDDDGLEYVSTVEHRHLPIYGFQWHPEKNIFEWGFDSIPHTLDAIRSSQYIANFFVEKARLNNQTFPTEEEEIAALIYNHSPIYTATLYPSSFQQCYFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHK5</accession>
    <name>A0A8J5JHK5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutamate receptor ionotropic, kainate 4-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Grik4-L2</name>
        <name evidence="8" type="ORF">Hamer_G006131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHK5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7156386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="190" mass="21279" checksum="000ED52CD4A21414" modified="2022-05-25" version="1" fragment="single">MTSYGGILTAMLTVPRVTIPIDSLADLVSQSDLPWRTVSGSFMLTFLEESEYELHQKAHMHQGPTIKTCLAERQNIADGKLAAICDDISMLKAMAEDFSTTGECHLYITREKVLSNLFLCLAFPKNSPYLAKTNYIVRVLLEAGLWDKWLGDQLANSSHCLRHPKLDRRRGGHQPIDMGSFIGPLLLLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIL9</accession>
    <name>A0A8J5JIL9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Actin-like 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Act-L21</name>
        <name evidence="12" type="ORF">Hamer_G006684</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIL9"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0558">Oxidation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7156693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="376" mass="41683" checksum="53DE861B10B5F26A" modified="2022-05-25" version="1">MCDDDVSPLVVDNGSGMVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEESPVLLTEAPLNPKANREKMTQIMFETFATPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTAYLMKIMTERGYSFTTTAEREIVRDIKEKLCYVALDFENEMNVAAASSSLEKSYELPDGQVITIGNERFRAPESLFQPSFLGMESVGIHETVYNSIMRCDIDIRKDLFANNVLSGGTTMYPGIADRMQKEITSLAPSTIKIKIIAPPERKYSVWIGGSILASLSTFQSMWITKEEYDESGPGIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIZ8</accession>
    <name>A0A8J5JIZ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G022340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045864">
        <property type="protein sequence ID" value="KAG7153984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIZ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="89" mass="9905" checksum="C60E79E06B5925C4" modified="2022-05-25" version="1">MLIRNLLRKILINKTTVLSCFAYSIVFDRSAKYFFLSVDSTASAISLAGYSYSQSRTTPLGYLQYNLTCFSPEDQDGWTSSAATGTIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJJ7</accession>
    <name>A0A8J5JJJ7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carcinoembryonic antigen-related cell adhesion molecule 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CEACAM8-L</name>
        <name evidence="2" type="ORF">Hamer_G019460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035076">
        <property type="protein sequence ID" value="KAG7158446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJJ7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF37">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 13, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="122"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="285" mass="31323" checksum="4BEBCECC300F7633" modified="2022-05-25" version="1">MKLVRKSLTGLYCVGDDWRVVLEKVVGCVGDDWRVVLEKVVGCVGDDWRVVLEKVVGCVLEKMVGCVMGEWWWAVLGEVVVGCVGGGGGLCWRRWWVLWELSLRDVRMSDAGLYECQLTTHPPASLFFTLKVVEARAVVAGGPEVHVHTGVKLRLHCTVELATEPPDYIFWFHNDTMINYLPKRPLKVVNHHFASSLVISNVTWADAGSYRCEPHLATPANLTLHVVEGEKHAALHNGHSEGAEQDTTAAADSAHLSPLMVAAAASCLLIFASAGHLYTLDSDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLZ9</accession>
    <name>A0A8J5JLZ9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase II elongation factor Ell-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Ell-L</name>
        <name evidence="9" type="ORF">Hamer_G011404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELL/occludin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLZ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031176">
        <property type="entry name" value="ELL/occludin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019464">
        <property type="entry name" value="ELL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010844">
        <property type="entry name" value="Occludin_ELL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF17">
        <property type="entry name" value="RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10390">
        <property type="entry name" value="ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07303">
        <property type="entry name" value="Occludin_ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144292">
        <property type="entry name" value="occludin/ELL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51980">
        <property type="entry name" value="OCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OCEL" evidence="8">
        <location>
            <begin position="407"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="212"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7158733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="516" mass="58604" checksum="EE77A03BAB962DEE" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JM76</accession>
    <name>A0A8J5JM76_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038254">
        <property type="protein sequence ID" value="KAG7157003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="540" mass="60325" checksum="759C6421A56524E0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMA3</accession>
    <name>A0A8J5JMA3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031526">
        <property type="protein sequence ID" value="KAG7160245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMA3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="126" mass="14596" checksum="02056517BA73CCCB" modified="2022-05-25" version="1">MPPPPRWLCPIPCEELQKEKISKIVDLIIAESTKDYKEKVQKEEIQENELSMSINQDKDDIIAKRPRLFAYIWAIDGKPVNKPHYSDARKTTRLDQRPEERVQGVSQLKTSGEESLEDVDGTWMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMC0</accession>
    <name>A0A8J5JMC0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Connector enhancer of kinase suppressor of ras 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Cnksr2-L</name>
        <name evidence="7" type="ORF">Hamer_G021653</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNKSR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031456">
        <property type="protein sequence ID" value="KAG7160275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09511">
        <property type="entry name" value="SAM_CNK1_2_3-suppressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049628">
        <property type="entry name" value="CNK1-3_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051566">
        <property type="entry name" value="CNKSR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017874">
        <property type="entry name" value="CRIC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844">
        <property type="entry name" value="CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844:SF42">
        <property type="entry name" value="CONNECTOR ENHANCER OF KSR PROTEIN CNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10534">
        <property type="entry name" value="CRIC_ras_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51290">
        <property type="entry name" value="CRIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="4">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CRIC" evidence="6">
        <location>
            <begin position="82"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="235"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="925"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1343"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1405"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1666"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1805"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="482"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="675"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="730"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="776"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="793"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="957"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="984"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1243"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1417"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1666"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1832"/>
            <end position="1844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7160275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1878" mass="202228" checksum="A9DD675CDAD32BF5" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JML0</accession>
    <name>A0A8J5JML0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F-box/LRR-repeat protein 4-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Fbxl4-L1</name>
        <name evidence="1" type="ORF">Hamer_G006252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JML0"/>
    <dbReference type="OrthoDB" id="63112at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="470" mass="52656" checksum="741A3FE3BA335B9C" modified="2022-05-25" version="1">MPPRKQVESLEHMCFMVMAGTLHRLAVELEEEPESCQVSAEELSSTVASLPAVINENMITKVIETIHQTVSRTRRTIGMRTCLEVLLQPHVQRLDLSGLFFKMRLPVAINMTIRNVVREQVGSMKNLMILNMVSKCSDEILCIVSQKCPNITEVIVSISDLVTDEGLKALALGCPKLEKLGISKCWEVTTDGIAYALQYGKNLQKLQCDQLGAVMINRFKKSNTTFKLTHFEQTQTLFEPQEEEIAWVGGACPCLESASLFVDDESLALVPQLGDIRVLEIETSAILGNGFVKAITNLGVSLLTLQLNCDEVNQEKIVLLGKCCPCLTTLHLTTATVEGDELLINPGQLFSSLTALHLQVWKETVISNECVEFFLMWCHKLESVVLKAELEFLTDQYLKRILAANPLTEAKRIIIASEKHVPLTLESVYRLMASCPSLENLGISSWDITEEEFFKIRDDVRKNNYNFMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMY7</accession>
    <name>A0A8J5JMY7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMY7"/>
    <dbReference type="OrthoDB" id="6382557at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="179" mass="20070" checksum="5E12D73583685001" modified="2022-05-25" version="1">MSSRPTKQRRVVKWDSRRTTKKVVGRDSMEDGGEHLPRPSQTLPLTFDLPVKAGRIGRGKALQMSTCSPIDHQSAKPINPGAYYTPVGITDCGLNVRPAVPGDCYVRKSWKNLSNAPVAYQVQQMLYEDQFTDDEPSNSSSFQKNSNHINGKNKFDWISDEYNFGEYQNPNVGNGLPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JN37</accession>
    <name>A0A8J5JN37_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Tigger transposable element-derived protein 1-like 325</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TIGD1-L325</name>
        <name evidence="2" type="ORF">Hamer_G013950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JN37"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="238" mass="26316" checksum="CA4FFDB4B807B7BA" modified="2022-05-25" version="1">MVLYKKLCQGNSMGLEVDDDDDEELVDEHRKELSTEELLEENETLKWSLATEESGEDEDKEESRIIPAKDLKDVFWCWNKLSKLVEDYHPDVASVEKGLSIFNDTVMSHFWESLLCGVAAAVTTPTHVWLVWSTLSLPGLMMVNVNTVGEVACASLCPPSRSSSGSPPPPWAQPSWAPTAVVVSCCPAPRHTPPPVPPSLHTHLHSLTPHTPRATHGSPPPTYSTITSLPTWKLCDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JN46</accession>
    <name>A0A8J5JN46_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">E3 ubiquitin-protein ligase TRIM71</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Protein lin-41 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase TRIM71</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Tripartite motif-containing protein 71</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">Trim71-L2</name>
        <name evidence="26" type="ORF">Hamer_G013969</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JN46"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035198">
        <property type="term" value="F:miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19812">
        <property type="entry name" value="Bbox1_TRIM71_C-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19796">
        <property type="entry name" value="Bbox2_TRIM71_C-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14954">
        <property type="entry name" value="NHL_TRIM71_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000013">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000025">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000080">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF48">
        <property type="entry name" value="PROTEIN WECH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="24">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="25">
        <location>
            <begin position="169"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="25">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="22">
        <location>
            <begin position="468"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="23">
        <location>
            <begin position="582"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="23">
        <location>
            <begin position="629"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="23">
        <location>
            <begin position="676"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="23">
        <location>
            <begin position="723"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="23">
        <location>
            <begin position="770"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="23">
        <location>
            <begin position="817"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00043228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAG7161337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="857" mass="93065" checksum="BC0025A6D2920F52" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JN94</accession>
    <name>A0A8J5JN94_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Homeodomain-like domain-containing protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G032230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037265">
        <property type="protein sequence ID" value="KAG7157603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JN94"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="2">
        <location>
            <begin position="11"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7157603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="8012" checksum="9F1F98916F7FD11C" modified="2022-05-25" version="1" fragment="single">GKELGRDTIVAIITPYKEGYKCKDIATRVGIGVQQVQKWIKKFRDGGEKLARCIPQRLEKVIKLRGKSLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNN7</accession>
    <name>A0A8J5JNN7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNN7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="59" mass="6604" checksum="F782F5D44AB19090" modified="2022-05-25" version="1">MSGTTSACPYMKLQRTSSAQPDHVTGTGSMRMLMAYTIFLLPRIKPTMLYSQTHNILHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JP54</accession>
    <name>A0A8J5JP54_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Facilitated trehalose transporter Tret1-like 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Tret1-L19</name>
        <name evidence="11" type="ORF">Hamer_G022412</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032177">
        <property type="protein sequence ID" value="KAG7159798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JP54"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7159798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="454" mass="49852" checksum="9C2EE62EC71BFB1B" modified="2022-05-25" version="1">MGDIGRSTSELLERNKEPSHLTQYIAAISVITMEQNNWFSSTFNLGALIGGLLGGMCVNTLGRRGTMLASVLPFLGSWMIIAFAQNFAMLVCGRVLAGLCAGVTCIAVPTYIGEFASPDIRGTLGTGFQLMVVVGLEYAYVFGAVMTTWRGMALVCAIPPVIYLFLVFFTKESPTYLLSKGKDKEAKEALQYFRGKHYDVEPEMQLMRKTQEEARQNTVSLSDLKKPYILKPLLISCTLMVFQQLSGVNAVLFNLSLIFEEAGSGLPDDVSSIIVGLVQVVVTAISGILMDKAGRKVLLIISAAAMIVSLVALDVYFYEKFLNEERAVETLSWLPLTCLIIFITAFSIGFGPIPWLMMGELFSLNVRGPASSLATMVNWTMAFLVTLLFQPLQEAIGPYGIYWLFAGFCAISLLFCILVVPETKGKTLQEITRHFGGPVTTEDATKKQEELSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPE6</accession>
    <name>A0A8J5JPE6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Receptor-type tyrosine-protein phosphatase eta-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Ptprj-L1</name>
        <name evidence="3" type="ORF">Hamer_G008957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPE6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035274331" evidence="2">
        <location>
            <begin position="26"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="399" mass="44443" checksum="D7CA54B150F02E3F" modified="2022-05-25" version="1" fragment="single">MGVQALRLTCAVLLLICWTSDPVNCQSVKIEGVSTNFFTISWPRVLQWFGVESFTITTQPEDSHSCQQTIPCKNDTCVYNSRGCSSIFPCTNTSIVVTGDNYSAPQLSLITDVIPLVASLNTTSKCTEVSVTWVYNDVCPDVAYITVYIERGEYYSTKNTSITSYVFQGLLIGTHYEVCVKAMAADLSTLGSHVCEYISTASDVVADLTLEALGSTELSANWLPPICPAGIGLYYEVQVEDETFFDYHYDENMQETNHTWSDLRYGNTYRPYLVKVEEISYTKLLVTWDFDTYQGDNSYDFKFNVTWGDSLENSAITQYYQYSIRGYNVSRENRRVCVRATQHDDFFSQNGCLGDPYVPTTQAPYPVIDGMSAGLIAFIVIGCLAAVFAIISIGSIAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRK6</accession>
    <name>A0A8J5JRK6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Alpha-mannosidase</fullName>
            <ecNumber evidence="11">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MAN2B1-L</name>
        <name evidence="13" type="ORF">Hamer_G004302</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRK6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10810">
        <property type="entry name" value="GH38N_AMII_LAM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000002">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000003">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000018">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000003">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000001">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048534">
        <property type="entry name" value="Man2a1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21260">
        <property type="entry name" value="Laman-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035338694" description="Alpha-mannosidase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="12">
        <location>
            <begin position="352"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7159628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="984" mass="110396" checksum="8D9900B52A4EC3F3" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JS20</accession>
    <name>A0A8J5JS20_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JS20"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="108" mass="12380" checksum="9DE88169EAEB8FD6" modified="2022-05-25" version="1">MEFGEGCGQHVCVHSFKDFPKNENVCNVKNYTVKLSKDVGFDKVEVNNVEDLLDSYKEELRNEELIQVDELQKPDEKEADNKTCSQADYQNTSNASNLVDELLTLFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSC4</accession>
    <name>A0A8J5JSC4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PiggyBac transposable element-derived protein 4-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PGBD4-L2</name>
        <name evidence="3" type="ORF">Hamer_G026193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029646">
        <property type="protein sequence ID" value="KAG7161163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSC4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="82"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="278" mass="32602" checksum="CC2CF0D316509540" modified="2022-05-25" version="1" fragment="single">MSSSTEDSEYEPSLRSLNTSDNSASSSDNDYFSTSEEEEEEGEGRAWRSLELSEERMNTPPPRFPFTGNPGIKIDENPAELSPFEFFSLFIDKRIIDSVLVETNRFAEQTGQDDSLWRPVTEAELFVFFAMKMLGGIVKMPEEEMNWSHDELLERPIFRQLMTMKRYSKIKQYLHFVDNETHDAQTHPNPKLYKIYDVFMTLCENFGKCYTPRQDVCIDESLMLFKGRLGWVQYIPLKRRRFGVKYFMLCESKTGYVYKMTIYVGKGTQFDPEYDAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUD1</accession>
    <name>A0A8J5JUD1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate sulfotransferase 3-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Chst3-L4</name>
        <name evidence="3" type="ORF">Hamer_G022804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033239">
        <property type="protein sequence ID" value="KAG7159369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUD1"/>
    <dbReference type="OrthoDB" id="5987729at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="410" mass="46399" checksum="00EBFC67DEC3AE24" modified="2022-05-25" version="1">MALKIKLLKLFTLVAVVIVLHYFVLGIIMIYSYSEGGGLWTTEGTPNQSLSASLGGVRHRVPNTKDIAKGMTAEGNPEPASGNNNEENEEGEAREYPEGGGRLSPPATSSSPMFVLLLSSLARGGSTFMSELLSTIQRSIVYFEPLWYIEKMECIQDPLCATEYLLAAFTCTFKPDFEKWLMGRHGFFSYFNADVRVCLMMKDNKSKNECLNKLSLPEMCRAAPVRIMKVIRGRISWLKDILSDPKINLKIIHLTRDPRGSLNSISKFGPTWPHDPHERCSVMKDDMDAYDKLSPKFPSKLLQVHFEDLCLHPENAIGNIFKFLFGNSSLPTATQRYINLHMNTEVKPNAMGTIKKSKSEFEAWRYKIPERLLSKVEVEPVCLYTIHRMRHTVFGTLERVRNSSIPLILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUW3</accession>
    <name>A0A8J5JUW3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUW3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="134" mass="14679" checksum="79E2BF6C93C551B1" modified="2022-05-25" version="1">MNADEIRNERSRRSSNRPTPEPNMAPSSAGIGAAHSASSGFWSSLYNSPRDSPARRISETMSRSSLGRDDDTLGGLSSPLWTRSVSRDTSDADTLFSEASTPFGTLPRVRTLRHSLHLPPPRLLPDSFFLSDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW86</accession>
    <name>A0A8J5JW86_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G004762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW86"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="66" mass="7030" checksum="C9FFD441E6EFA06A" modified="2022-05-25" version="1">MASTPSSVEDHLGVLERFVVLLYDRASSSVVNEASKQAALLEHTNLPGRLYLGTDVGGCSLASIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWS8</accession>
    <name>A0A8J5JWS8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proto-oncogene DBL-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MCF2-L</name>
        <name evidence="5" type="ORF">Hamer_G011974</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7166037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWS8"/>
    <dbReference type="OrthoDB" id="6349188at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="285"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="861"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="974"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7166037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1011" mass="114891" checksum="50C9B3560BE3A21C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYH0</accession>
    <name>A0A8J5JYH0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Aggrecan core protein-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Acan-L4</name>
        <name evidence="2" type="ORF">Hamer_G024351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024923">
        <property type="protein sequence ID" value="KAG7164801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYH0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="447" mass="50996" checksum="6CF3051714F8A794" modified="2022-05-25" version="1">MDTIWGHLASLKQTKVHSNYLQHSPSPTTLTITYNTHHHLQHSPSPTTLTITYNTHHHLQHSPLPTTLTITFNTHHHLQHSPSHTTLTITYNTHHHPQHSPSPTTLTITYNTHHHLPQHSTITFNTPPSSTTLLYHPKTSTSPTTLHHHLQLSPITYNTHRTYNSRHHLQLTITSLTITYNSHHHLQHSPPPTTSLSPLQPHHYLQHSPSSTTLTITPQNHSPSPTTLTITYNTHHHLQHSPLPTTLTITYNTHHHLQHSPSHTTLTITYNTHHHPQHSPSPTTLTITYNTHHHLQHSPLPSTLTIIYNTHYHLKHSPSPTTLTHHLLTHHHLQHCPSQLTLTILLAFSITSNLPIIYNLTIILQPHHHLQHSYPSPTTLTITYNTHHHLQHSSSPTTPTSPTTLTITYNTHHHLQHSPSPTTLIITYNTHHHLQHLTLSMLSMMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYT4</accession>
    <name>A0A8J5JYT4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoglutarate-dependent dioxygenase htyE-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">htyE-L2</name>
        <name evidence="3" type="ORF">Hamer_G005454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYT4"/>
    <dbReference type="OrthoDB" id="6373289at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="175"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7167117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="315" mass="35047" checksum="67EF23401F24C9F7" modified="2022-05-25" version="1">MKSRMSSKLSSTKKVPVIDLGHLGLGQEPGQEEWQRVTRELYNALTEFGCSYLANHGVPDDQWRLLYDSTIAFFNLEQGKKDRYAFDADKLSGYIGMGSESYSGSTRELCEGLLARRTEQLPDEPEIPSLKPAAESFLKSCKELSERIMAALSLSLGKDPEHLLSIHKERGTDKNITTLRFNHYPPVPSTIPEGTFRFGAHRDFGTITFIFQDDCGGLQVQDSEGSWFDVTPVPGTIFLLAGEFLQFHSGEKFLAPTHKVLIPAGEEARGTARVSILYFVAPDNHIPMRPPGNPSTDTPMTVQEYITSSIKNAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYY9</accession>
    <name>A0A8J5JYY9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">UbiA prenyltransferase domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">heix-L</name>
        <name evidence="12" type="ORF">Hamer_G010992</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYY9"/>
    <dbReference type="OrthoDB" id="203513at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042371">
        <property type="term" value="P:vitamin K biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000005">
        <property type="entry name" value="UbiA prenyltransferase domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00751">
        <property type="entry name" value="menA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929:SF0">
        <property type="entry name" value="UBIA PRENYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7166171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="314" mass="34488" checksum="A444F6C2C0ADF455" modified="2022-05-25" version="1">MMNGKSSTPEKKRRGSPLMKLSAYVLALRPWSFSASLMPVMLGCTLAHKATGEFSLVALITTALTALSVHAAGNVVNTYFDYVKGIDSKKSDDRTLVDQLLSKDEIVTLGVILYSIGCAGFVILTMVTTVRLEHLALVYFGGLSSSFLYTGGIGFKYIALGDVMILIFFGPMTVLFSYMVQAGHVQWATILYAIPLALNTEAILHSNNTRDLESDSQAGIVTLAIIIGRTASEVLYAIFLFAPYTMFAVWGMKYSSMLFLPLITIPEAFRLERHFRTVGKETIPKRTAKLNAWLGFLYVLGCAFSDPAKLPYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZ16</accession>
    <name>A0A8J5JZ16_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hemicentin-1-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Hmcn1-L5</name>
        <name evidence="4" type="ORF">Hamer_G014491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026055">
        <property type="protein sequence ID" value="KAG7164020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZ16"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF21">
        <property type="entry name" value="SEMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7164020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="204" mass="22753" checksum="EBEA094F0337895B" modified="2022-05-25" version="1" fragment="single">QQGRRRCNSPAPQHGGSPCQGDETHTRPCRPQPCPVDGNWSPWDPWSECSTTCDSGVRLRSRYCMAPAPLYGGRPCPGVAVKEEDCRLRDCPVSGEWSLWTSWSDCSITCGQGLHQRTRLCDSLQLGEQSVRVMTWKSCLVQTHRLDDNWGSWEPWSVCSVSCGGGVQRRQRECNDPPPSNGGWFCPGSDTLEDYCNLDMCPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0B6</accession>
    <name>A0A8J5K0B6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier organic anion transporter family member 74D-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Oatp74D-L5</name>
        <name evidence="9" type="ORF">Hamer_G010186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0B6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF159">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 74D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="640"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="789"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="826"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="878"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="8">
        <location>
            <begin position="714"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="908"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="908"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7167790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="933" mass="97490" checksum="B0D7BE57556A1214" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K266</accession>
    <name>A0A8J5K266_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-galactose dehydrogenase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LGALDH-L</name>
        <name evidence="2" type="ORF">Hamer_G010926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K266"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="272" mass="30687" checksum="D41D502C536209EC" modified="2022-05-25" version="1">MDQLTYVANFHDDDAVKKMSYQPLGNTGLSVSRISLGGGPLGDMYGSNKEEEYIATVHLALKSGINYIDTAPWYGNDSNLNTLTALKDVPRSAYYIGTKVGRYEQDLEKQFDFSGKRVEQSVDASLKLLGLNYVDVIQVHDLEFAESLDIILEETLPALQKVVEQGKARHIGITGYPLHLLQEVIERSSINIELVLSYARNTLLDDTLKEFIPFFQNLDSVLTPPTPLEEKVALELKLKFFDPLPRKHWEGVGPAQYWKSLRQLRGELPQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3C2</accession>
    <name>A0A8J5K3C2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G022663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018361">
        <property type="protein sequence ID" value="KAG7169125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3C2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF3">
        <property type="entry name" value="MYCBP-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="189" mass="21745" checksum="AF2513AFF915DACE" modified="2022-05-25" version="1">MCQLEARHPDVYDKFSRGFHVIRRSNQYWAGLSSDLMIEQTLMRSLKSGGGLTHGSGMTEEMRALWTMSIPITSEYTNAMQEFNDLTYTTSEQHRESTEARMKRDHSDLEKIKEKLSTCMPFSPDPSLRNIITGLVAKEDVNVHEYETVGNEIIEKMVGKPVFGISFKRNDRAKTLTRVHHQICPRPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3F5</accession>
    <name>A0A8J5K3F5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transferrin receptor-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G002645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3F5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF77">
        <property type="entry name" value="GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28462" checksum="EE7B2698A0399A65" modified="2022-05-25" version="1">MIQTRKIMCVGISVPRYVVVAAQWSTFSLRHSQYDTRYSYTSLLDPDYKWTHMITSLVGAVMMVLSENELPPVVMTELSTDLYDGWRRFLGLHATTLHKSGYNFTGIIDAIEAELIRMNSSLSDLDRLYHTMPNYVHQYSMPVTGLAHYRQVEQRLRWLTNLERGLLGPRGVGRTFTTNLMVGPDLENPYRATHYPHAAQAIIHALLQKTPWESVHQELSYILAALTSYRQLFPIDVPVSTIETQDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3K7</accession>
    <name>A0A8J5K3K7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lifeguard 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Lfg1-L2</name>
        <name evidence="6" type="ORF">Hamer_G010500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3K7"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10428">
        <property type="entry name" value="LFG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF47">
        <property type="entry name" value="TRANSMEMBRANE BAX INHIBITOR MOTIF CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7166829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="234" mass="25989" checksum="D038887FB69F6138" modified="2022-05-25" version="1">MDYDPENNGGLSFSEKSIRMGFIRKVYSLLVVQLVITFGIVALFIWVPQVTDFALHTPALFWSAFGVTFAMIILLACCSDFRRKTPFNYIALFVFTICEGWLLGCASATFTAWEVTIAIGITIIICVALTIFAFQTKWDFTMKSGLLFVLLISLLMFGIFAAIFQSKVLNIMYACLGALLFSAYLVFDTQIMLGGNHKLAISPEEYVFAALNLYLDVVNLFMYILALTGGGNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3U6</accession>
    <name>A0A8J5K3U6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Toll-like receptor Tollo-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Tollo-L2</name>
        <name evidence="13" type="ORF">Hamer_G011542</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6364554at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035312048" evidence="11">
        <location>
            <begin position="16"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="977"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="1032"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7168871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1350" mass="151828" checksum="970A1F5360D6D228" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3V3</accession>
    <name>A0A8J5K3V3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3V3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="137" mass="15742" checksum="1351B1FD2AA3D892" modified="2022-05-25" version="1">MTVLFSDDEWVVWGSQTLRLQILLTSLILTMSSSVDDFLMLTATEENKEKEDDFVLEVNEIMLKQMDEFFKSAVEHAQHAVDMDHSLERSHYFSHGLQPTCAPYKQLYSQNNMLQNTPLLPSSSGLCQPLQFHTPCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K480</accession>
    <name>A0A8J5K480_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Rnf181-L</name>
        <name evidence="11" type="ORF">Hamer_G017148</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNF181 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K480"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16669">
        <property type="entry name" value="RING-H2_RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF16">
        <property type="entry name" value="RING_U-BOX SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7167238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="153" mass="18068" checksum="43B1323995D4FAC7" modified="2022-05-25" version="1">MSSYFDEHDCQPLRAGQLPDHFLHMARLLLHGGYWQDMQVEFTQLFGFGERPPPPTSKEFIDQLTTSTVSQRGGQCPVCLKEWTEGEEMKELPCKHKFHPACILPWLEKTNSCPMCRYELPTDDEDYEEYRRQKKRAKDREAEIEMLHHSMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4Q8</accession>
    <name>A0A8J5K4Q8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Run domain Beclin-1-interacting and cysteine-rich domain-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Rubcn-L</name>
        <name evidence="4" type="ORF">Hamer_G020949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017704">
        <property type="protein sequence ID" value="KAG7169257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4Q8"/>
    <dbReference type="OrthoDB" id="10067503at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17686">
        <property type="entry name" value="RUN_RUBCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052428">
        <property type="entry name" value="Autophagy_HostDef_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048569">
        <property type="entry name" value="RUBC_PIKBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45971">
        <property type="entry name" value="PHOX (PX) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45971:SF1">
        <property type="entry name" value="RUBICON, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21054">
        <property type="entry name" value="RUBC_PIKBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="3">
        <location>
            <begin position="69"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="785"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="833"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="792"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="833"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="871"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7169257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1212" mass="133356" checksum="9F0634EF925F5747" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4U9</accession>
    <name>A0A8J5K4U9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DDE superfamily endonuclease domain-containing protein 47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G010303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4U9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="152"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="339" mass="38466" checksum="129F79C27FEA029B" modified="2022-05-25" version="1">MPRRHRITSATDRERIIEAYRAEQDFLVVAAALGVQRTTAYSIVRVYQRENRVEAAHAGGRHKIIDNETLDLIVMLLEANPMMTLREIKEEVMDIFPTKQHFSEVTLSRYLEGKLISLKMSCDSPAERNSPAVKEARHAYATWMLATGLQQQLVYIDETGFNLWTKRTYGRARRGEREHRAVGGQRGRNTTVIAAIAEHCGILYHEIHYGSVTKEVFSDFISSLAAIIGDARSILVLDNAPIHNSIAAVYPELNFKFLPPYSPCLNPIENCFSVFKSYLKQYLHREAPRCNAAHARQEGVTLNALRENILQVGVEFALPSVTEHVVSQNYNHVNTYLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4Z0</accession>
    <name>A0A8J5K4Z0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tigger transposable element-derived protein 1-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TIGD1-L8</name>
        <name evidence="6" type="ORF">Hamer_G013073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4Z0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF26">
        <property type="entry name" value="TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="86"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="490"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="577"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7167594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="621" mass="70317" checksum="8CEDDF07F2AA5EEE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K675</accession>
    <name>A0A8J5K675_HOMAM</name>
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        <recommendedName>
            <fullName evidence="6">DNA polymerase II subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Pole2-L</name>
        <name evidence="9" type="ORF">Hamer_G010179</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K675"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024639">
        <property type="entry name" value="DNA_pol_e_bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12213">
        <property type="entry name" value="Dpoe2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase epsilon subunit B N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="163"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="244"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7167785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="376" mass="42019" checksum="BCE49C21395FD7E7" modified="2022-05-25" version="1">MSSNKSHVINLFKLHGLAVRSDGAKYLCELLDPLPKDEHDEWIEKVIDAVQKLPISSTLISKEHIHKAAQEVGTSENDDIENLLQIVDIYKVPKLMYNLERKKFVLAPTRARDLHGDASDKAALFRDRALIGNINYFGGQGNVCAKNNPRLQQIEQENKDAMFVVLSDVWLDKIKVTEKLQTLFNGYAQFPPTAFIFCGNFVSSCHGAQQAHDLRQALGSLGTLIAGYPELMAHSRFIFTSPANITEEIKKAVPSAFFVSNPCRLLFCTQEIVIFRENIVAKMCRNCFAKTLVSQGHLAALPLHVLPVYWGLDHCLSLHPTPDVIITADKGDSFTTTHNQSIIMNPGSFAKTDFSFKVYMPATRQVEDSQIADDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8I9</accession>
    <name>A0A8J5K8I9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G013926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012946">
        <property type="protein sequence ID" value="KAG7171121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8I9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="315" mass="35457" checksum="B3FF663103298770" modified="2022-05-25" version="1">MVVFGVGDSCQHLGRNITTLLAPVAWLGALLGVFPYSRRRATIDPGESLADTMEQEPVTDTEVMYFGWWAVISHRREFESHLAAMEKYPTAFRDNRSCLVLMLGLIFFLFNLVLQMDGMAAHFSGMENVMISVLWVLLAHHTHQLHSANATLSYALQSSDLCCLQTSRKLVMQARGLCNGTEDLMKTGIMPQLLRTSTYLCYSLAIGYLSLEQPQVAVMWENTWIRYTLGNATIHLLQGKGEGHDQYSREVSGIRRDLLTAPLVFTVNDFINLTLPNLWNLLQFLITQVVILVQFTQYDLDSPLVEATSNTTTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KBV1</accession>
    <name>A0A8J5KBV1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Presequence protease, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pitrm1-L</name>
        <name evidence="13" type="ORF">Hamer_G024316</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017232">
        <property type="protein sequence ID" value="KAG7169348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KBV1"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="12">
        <location>
            <begin position="515"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7169348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1020" mass="114052" checksum="DF15ADBC47BCA2A4" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KHS5</accession>
    <name>A0A8J5KHS5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G013402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KHS5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7170590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="236" mass="26330" checksum="6DB5FDB9C17699F2" modified="2022-05-25" version="1">MNDCRSTFVTQVVMHLAVHGLRWLVGLSLWGGCFTLTFVNGLVQVEVLEVGCSDDFVHTFGATVGWTVPIFCLNTCSKENKTNGLKLNNKITTQVNLEEYPGSVLVTYQEHVMCSEPTYSSERISLCSHEEAENCMVLHAADEAHRRYRKIFIKTVDTDVVVLCIGFATKIGCECHWVGFGTGRSFCYLNVTQMAEVLAFQSQFVALLPSYWTQDFDQVLSIQAQAEGGPLQLQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKQ1</accession>
    <name>A0A8J5MKQ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tumor protein p53-inducible nuclear protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Hamer_G018523</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
            <location evidence="10">Nuclear body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043933">
        <property type="protein sequence ID" value="KAG7154792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKQ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029431">
        <property type="entry name" value="TP53INP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31671">
        <property type="entry name" value="DIABETES AND OBESITY REGULATED, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31671:SF3">
        <property type="entry name" value="DIABETES AND OBESITY REGULATED, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14839">
        <property type="entry name" value="DOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="176"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7154792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="298" mass="32016" checksum="57D54C799BABA491" modified="2022-05-25" version="1">MLANLTSLIWGSESTPTTTTTTTSAVVTTTTTCPTSEVEAPETQSLVNIRASTPADEEESDWVLVDRAEVGEASYGEGQGVQLIATTTRRSTRSTTAAAAASIPTSPISISGETCEGGTQGWLMTPPPCFTRSQTAPLATSPLENLLIEHPSMSVYLPRPTYTSAAIARIFPRRIMSHSSPSSHSPPSASPSSQPSPVENEDSPMREDAGDEAGRQVVEAPATRSSVSQRAATLLQAIDVLRPAQKAQRRREERRLKRKPLERSNKAREVAAAGNKRAKRNDMMVPGKFSRAVNNRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKT4</accession>
    <name>A0A8J5MKT4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neurogenic locus Notch protein-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NOTCH1-L4</name>
        <name evidence="5" type="ORF">Hamer_G015665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043233">
        <property type="protein sequence ID" value="KAG7155061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.20.10">
        <property type="entry name" value="Plasmodium vivax P25 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048407">
        <property type="entry name" value="Dumpy_DPY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22963:SF39">
        <property type="entry name" value="DUMPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22963">
        <property type="entry name" value="ENDOGLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21164">
        <property type="entry name" value="Dumpy_DPY"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="51"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90148">
        <property type="entry name" value="DPY module"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="348"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="415"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="481"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="604"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="724"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="793"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="890"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="973"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="1016"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="1056"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="1098"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="1161"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="1214"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="1318"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="1536"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="1596"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="1645"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="1764"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="1824"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="1873"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="1932"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="2027"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="2142"/>
            <end position="2179"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="2200"/>
            <end position="2237"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="2246"/>
            <end position="2284"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="2350"/>
            <end position="2389"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="2410"/>
            <end position="2447"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="2456"/>
            <end position="2496"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="2561"/>
            <end position="2599"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="2620"/>
            <end position="2657"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="2684"/>
            <end position="2723"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="2797"/>
            <end position="2836"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="2899"/>
            <end position="2938"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="3002"/>
            <end position="3042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="796"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1164"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1327"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1346"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1599"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1827"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1935"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="2203"/>
            <end position="2213"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="2413"/>
            <end position="2423"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="2623"/>
            <end position="2633"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7155061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="3107" mass="329301" checksum="597390B99EFA0FA5" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLH0</accession>
    <name>A0A8J5MLH0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-aminoadipic semialdehyde synthase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Aass-L</name>
        <name evidence="9" type="ORF">Hamer_G027763</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040415">
        <property type="protein sequence ID" value="KAG7155794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLH0"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12189">
        <property type="entry name" value="LKR_SDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000087">
        <property type="entry name" value="alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="8">
        <location>
            <begin position="45"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="7">
        <location>
            <begin position="205"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7155794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="700" mass="77251" checksum="794DA9BD6F651693" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMN4</accession>
    <name>A0A8J5MMN4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038264">
        <property type="protein sequence ID" value="KAG7156994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMN4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="373" mass="39742" checksum="ECD5029A5C9F9219" modified="2022-05-25" version="1" fragment="single">ASKVKLCNAVSSRLFGDSVDVSLREDHGEASQVNVAESRSVNDELRLLESQIRLKEVGIRQAEAEAKAKEAEAKAKEAEAIAKRVGIRQAEAEAKAKVAEAAAKYGQTAMIVTEENITSPVGVMADLSKADSMPIGLVSTKVEARESAVSVLASRDFDLFLESFAKDPDVGTFRPFLSQGTVEVDGVETPVTILRDSGCLQTLIKEGVVAVRKTDNMSFWDPFGVKSSCFSGIAIVACVHELPVAGLDLIVGNDLAGGQMGNVTPPPVLRERSESNAELQQLEDDMPGVFPLCAVTRSMSMTNDHNVTPVVDDSLSLETLFANPIASQDISSAVNAVTGRVALIAAQEQDDSLRLLFDQVSDSANDSGPTTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMT2</accession>
    <name>A0A8J5MMT2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G020310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038254">
        <property type="protein sequence ID" value="KAG7157025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMT2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="8235" checksum="20FAC5B94359CD7F" modified="2022-05-25" version="1">MVSFWGSERQMVKIGNSEHQLVFILSSERQLMNVRGSEGQMVKFWVLNTICKSFEVLQVIRQGYGILEDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPB2</accession>
    <name>A0A8J5MPB2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein 94-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Tmem94-L3</name>
        <name evidence="2" type="ORF">Hamer_G027393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034306">
        <property type="protein sequence ID" value="KAG7158843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPB2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="229" mass="26242" checksum="6382F3C8C1110057" modified="2022-05-25" version="1" fragment="single">MTADHSSQLRPNFPFKFFLSPYHVINNQEMACSADGLPTSEALSLLHEDISIALDEYQKTEAEKNKGFGPKSVLYEAFHHKSSLSVFHWTSVIALIVEGIVLLVAFAACNDPRYQHLPAESFFIFLAVILNVYLVWWDTQLRHKEVPRLTHNVLKDLKEYHGNVLWSAENYPHLHSPCITLQWTRRDGNTVNLPWSLLVRGDIILMKPGQKVPARCRPMQVSSIIFIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPU5</accession>
    <name>A0A8J5MPU5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-L-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ccnl-L</name>
        <name evidence="2" type="ORF">Hamer_G016645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPU5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="248" mass="27893" checksum="451A30108DE96132" modified="2022-05-25" version="1">MVVRERINQDDDDKDRRMVVRERINQDDDDKDRRMVVRERINQDDDDKDRRMVVRERINQDDDDKDRPGDKGVKATGGAEVVPGLVGVGTERVVTTDQLEGTVWYDERLDLLQLWEVNTGHNSQPEENKMAAGAIEVMSPPAKKYGSVVITLDNVLIPPDKLSPSPSQQDGLDSEIEMDLRILGCELIQTGGILLKLPQIVLVDHSRPVPMVFQHLGWGGLRMSCNNVKADSGSFRWTTKLILDASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPX8</accession>
    <name>A0A8J5MPX8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033266">
        <property type="protein sequence ID" value="KAG7159364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPX8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="251" mass="25629" checksum="F4E9CBBDF058C095" modified="2022-05-25" version="1">MKGDRGVVTISGAAVSDDPAGAPHPTPPSASSVAPPRPTPRAFAPAGGGFLRRLSRYASRVVPLSATAIREVPDYGATVDALNDLQGGTADTGSGADGTDVAVQVSQEAGAGGSRVNIPVLHITRSASYERAISSNRMLTSTKPRAPPVPTSTAKTTRSRKLTSRKKSNVSDTSRSSTTSNESNSAVTSSVTSSLTTTTSTVTAGGTGSLEVRVAPTAAPRYSIRNSLAVEEGRSSSTGQHLLHSLTSELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQB1</accession>
    <name>A0A8J5MQB1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein 39C-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ttc39c-L3</name>
        <name evidence="2" type="ORF">Hamer_G026928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032274">
        <property type="protein sequence ID" value="KAG7159770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQB1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="295" mass="32343" checksum="285CD3D87FE5EF01" modified="2022-05-25" version="1" fragment="single">MCSAGGNSNTSGGGDKGDGRGAEAESGSGQSLGPEEYTRLARDGIQLMLNNRFTEAEELFRHHTQDNLHMAMGHCYLTFMNAVMSFEEEKVTYSMETLRSMERRCGGGENGWFSSVKSIVMGSRNGQEQGEEPGSQLEQQVILADCQVLLAILTFLQQEIGSYVKGGWVLRKAWKVYEHAYTKVKRLYKQTFGEAQDVPPSSPTEEYHSSLHTNTDDLKSPGSWSVGPTGVPGPAEDSSESSHHSAPSSSSTSTLGLRIPLSKSVPNLKGFLYSNNKHQPKSLLIHDIAYLHLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQH3</accession>
    <name>A0A8J5MQH3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transient receptor potential cation channel subfamily A member 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Trpa1-L2</name>
        <name evidence="6" type="ORF">Hamer_G017421</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7159979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQH3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="707"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="779"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="803"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="835"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="875"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="937"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="412"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="445"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1081"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7159979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1130" mass="128909" checksum="708374322010DF94" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQY2</accession>
    <name>A0A8J5MQY2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyphosphoinositide phosphatase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FIG4-L</name>
        <name evidence="6" type="ORF">Hamer_G001869</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQY2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="161"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="715"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="752"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7160580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="972" mass="110830" checksum="98CD809D306077D6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR14</accession>
    <name>A0A8J5MR14_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G021372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030798">
        <property type="protein sequence ID" value="KAG7160763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR14"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="9286" checksum="E5149AC469F4A34A" modified="2022-05-25" version="1" fragment="single">PKMTQNYPGEGKVSAVGGVFVCRVSQHTCTPARDNTLLRYVNQRTMATNTTAMSTRCARNGNPTRRYVTTTGYTQETPIVARSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRQ8</accession>
    <name>A0A8J5MRQ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Ionotropic receptor 25a-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Ir25a-L3</name>
        <name evidence="21" type="ORF">Hamer_G007742</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRQ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000160">
        <property type="entry name" value="GLutamate Receptor family (AMPA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000078">
        <property type="entry name" value="glutamate receptor ionotropic, NMDA 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000143">
        <property type="entry name" value="Probable glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 21" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="601"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="956"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="20">
        <location>
            <begin position="493"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="19">
        <location>
            <begin position="497"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="104"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="725"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="873"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="15">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="15">
        <location>
            <position position="703"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="885"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG7160957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1016" mass="112624" checksum="6B2AF32FEE7E6596" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSA9</accession>
    <name>A0A8J5MSA9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate receptor-like 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Glrk-L26</name>
        <name evidence="16" type="ORF">Hamer_G007835</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSA9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="598"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="667"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="483"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="606"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7162320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="956" mass="103669" checksum="9F4AAB3528262FFD" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSB2</accession>
    <name>A0A8J5MSB2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSB2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="80" mass="9000" checksum="8A77D5376C8BA120" modified="2022-05-25" version="1">MTYPKLIKKQCPLPSHHATCVPRQDFPQDEEEEDIFGVILCEVYDNVVEHREGGDEGGNGRGNGEGKEKEEEIEKEKGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSG9</accession>
    <name>A0A8J5MSG9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gonad-inhibiting hormone-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Gih-L</name>
        <name evidence="2" type="ORF">Hamer_G007558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSG9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2010.10">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035957">
        <property type="entry name" value="Crust_neurohorm_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81778">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="80" mass="9365" checksum="9F38E2CB94E3FEA3" modified="2022-05-25" version="1">MTSYLEAYKSDTCGVVAIRQLQDQAKDKIPRAFPVINQDIPTLKDCFHTMDFLWCVYATERHGEIDQFRKWVSILRAGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTJ2</accession>
    <name>A0A8J5MTJ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA transposase THAP9-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">THAP9-L2</name>
        <name evidence="2" type="ORF">Hamer_G001961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7162936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTJ2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="1">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="82" mass="9266" checksum="D519646D07975FBC" modified="2022-05-25" version="1">MVQYSRSETRITEASFSALKQKVKKSTDETSGNILSLVMDEMAIRQHVEWDGKKYHGFIDVGTELDDPLPVAKEALTFMEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTQ6</accession>
    <name>A0A8J5MTQ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of cytokinesis 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PRC1-L2</name>
        <name evidence="3" type="ORF">Hamer_G002237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTQ6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7163161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="614" mass="72692" checksum="6AAA797A2AAC9A43" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU44</accession>
    <name>A0A8J5MU44_HOMAM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G014283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7164153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="72" mass="8372" checksum="12F28319C9B7DA48" modified="2022-05-25" version="1">MKLRTFSGTPDNLDQINVSEWIAEAKRNIRLLGYKGRKAVNYILKFLTGPAQKRVEKLPWSDSCDREEISQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUC5</accession>
    <name>A0A8J5MUC5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative actin cytoskeleton-regulatory complex protein PAN1-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Pan1-L6</name>
        <name evidence="2" type="ORF">Hamer_G002845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7163627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="25"/>
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            <begin position="27"/>
            <end position="37"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="161" mass="17270" checksum="24EA6625380DA625" modified="2022-05-25" version="1" fragment="single">HLNDSLASINSQSFKGANESTSTNPFGEDDNDDDDDDSIHNGLTREARSRKSFSVMSSSPLQRDGVRSSLPHTARIMTGRKKRQAPLPPSPRPPASSTSSNDRFGHDTSSLSRGGSPLSFNQGAQRKDSTASTSSLTTSPRKTAPPRPPPPKVKNDSPTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUK5</accession>
    <name>A0A8J5MUK5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Hamer_G027999</name>
        <name evidence="1" type="ORF">Hamer_G030443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028851">
        <property type="protein sequence ID" value="KAG7161668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="120" mass="13677" checksum="75DF0D7B3027ACE2" modified="2022-05-25" version="1">MEKEDIVAARNKYLSYIQKNRESSNPRPEVYLDETWINQNQCVERCWTVNDGSAGPKLKSGRGARFIIAHAGGRQGFIPGALLMFRSKNGAKGDYHDSMDHERFKAWFKEQLLQNIQGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVF5</accession>
    <name>A0A8J5MVF5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor TFIIIB component B''-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BDP1-L</name>
        <name evidence="3" type="ORF">Hamer_G003688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
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            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIB component B'' Myb" evidence="2">
        <location>
            <begin position="850"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1074"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="721"/>
            <end position="731"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="777"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="975"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7164479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1187" mass="131107" checksum="010809AE0B696634" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVS9</accession>
    <name>A0A8J5MVS9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">alkaline phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Alpl-L5</name>
        <name evidence="5" type="ORF">Hamer_G019419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010024443">
        <property type="protein sequence ID" value="KAG7165232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVS9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035241052" description="alkaline phosphatase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7165232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="106" mass="11719" checksum="B7321D12CE7670AE" modified="2022-05-25" version="1" fragment="single">MVGGRCKSCLVMVLVLTLSTSAVIFPSPNARETETSFWFEKMRQEINDALERPKNTGRAKNVLFFLGDGMGITVSTVGRIFKGQKKGVSGEEGHLVWERFPNVGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWE6</accession>
    <name>A0A8J5MWE6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pro-resilin-like 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G011160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWE6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035253900" evidence="3">
        <location>
            <begin position="17"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7166328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="117" mass="13602" checksum="67A35A91B845D89D" modified="2022-05-25" version="1" fragment="single">VLLLLAVVAVVAVAAADERPSYYGDHEDAKYKFKWLVKNDYNHYGHEEIRDGDHTQGSYFVSLPDTRKQIVTYYVDGDSGFVAEVKYEGEAHYPETYIKYNDYEPPKYDYKPLYVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXH9</accession>
    <name>A0A8J5MXH9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase (NADPH)-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BLVRB-L</name>
        <name evidence="2" type="ORF">Hamer_G013663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022272">
        <property type="protein sequence ID" value="KAG7166639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXH9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="135" mass="14630" checksum="6344CF004ED9C367" modified="2022-05-25" version="1" fragment="single">CEVTAFVRDPEKLPESIASQVTVKVGDVLDASAVDEAVSGQDGVVILLGTRNNLSATTLMSEGTKNILAAMDEHGVKRVSGCLSAFNFWERSKVPERFLPILEDHERMLTALKASNQEWIAVLPPHITGKPCNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXS7</accession>
    <name>A0A8J5MXS7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein TEX261</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Hamer_G002393</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXS7"/>
    <dbReference type="OrthoDB" id="28257at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144:SF0">
        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7168365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="202" mass="23345" checksum="224C2F0A43CAD6BA" modified="2022-05-25" version="1">MPGLLYLLSWISTLVHICLGTLALAAALYYLAELVEEYTSTAAKVLRYWIWVTIGLYILLFMFESVPTSVILCGFISQLVHLSILRTFPFFFLTSLPFILGVILFFVNHYLAFSFFAAYYYPASEVLAYFTLYIWLVPFGFFISLSANENVLPTRAESRPLLSNDDDFVTGYFNKKGKRYGLLSFFNYLKEEFFPQRGKKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZ39</accession>
    <name>A0A8J5MZ39_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine/threonine-protein kinase 32B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Stk32b-L</name>
        <name evidence="10" type="ORF">Hamer_G025438</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017634">
        <property type="protein sequence ID" value="KAG7169268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZ39"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000347">
        <property type="entry name" value="serine/threonine-protein kinase 32A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7169268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="438" mass="49898" checksum="1EE52642D6646FFC" modified="2022-05-25" version="1">MKKNKILHRLKLTSLTGVFYFPVGFDHFQVLRAIGKGSFGKVCIVQKRDSKQMFAMKYMNKTQCEARDALSNVFREIEILASLNHPFLVNLWFSFQDSEDMFMVVDLLLGGDLRYHVQQGVQFTDQVVRLYILEVASAVSYLHARNIIHSPSPQGHVHLTDFNIATVLRPGQVATSMSGTKPYMGKRPYDIHSNTSLHEIRMMFLQVPSFPTSCHPGLAHIISKKDHLNCDPTFELEEMIIESRPLHKKKKRLSKQKSIRDTHTSISGTTEAEAVVYKEMLVFNRELEQARRERERREQEWQAELEESMKMSDPTGHGCNFAGSNTSTPIKRRTKSCKGGVEKRHRDDRHKQEGRAASTPSTSSSVSSLLVSPTDRTTLPKIAVSPSNVKARIAGSPKVCERERERERERERGGGECVCVCEREREKALTVPGWPHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZ48</accession>
    <name>A0A8J5MZ48_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative leucine zipper transcription factor-like protein 1-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LZTFL1-L8</name>
        <name evidence="2" type="ORF">Hamer_G029043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019422">
        <property type="protein sequence ID" value="KAG7168709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZ48"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="196" mass="22593" checksum="827F66A85BB9491E" modified="2022-05-25" version="1" fragment="single">VHRMSQKEIRTRSKSSCQLSHLVGTCRELPPAELTTARDLLGYGLFRREMNEEDRRNYPVDHLVNNDIVPGLLAHWRKANALFTGPVINTEVRIKSKMKALWNMALKVSMGNELAFIRGKREKVGSVGSHQMGLADRPETRKQEARQKRKAEEKRRRKAEESAKKEEELRKESLLEMELEETGDTPEKAEKRTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZN1</accession>
    <name>A0A8J5MZN1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glutamate receptor ionotropic, delta-1-like 44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Grid1-L44</name>
        <name evidence="1" type="ORF">Hamer_G019711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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</entry>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2P3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="141" mass="14870" checksum="D2C56D8AE7E5251C" modified="2022-05-25" version="1">MVRGATGGDMVRGATGGDMVRGATGGDMGVEVKLSTHSPAVIVARVFNSRHMAGDYELPGVVNSEAWVNQNGCVSCDVNKAPTSSTQGNVTWASLDTGWGSPAQVLKLSVSFPSLETTQHNDGTNNRVMVEEYTKITKTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2P8</accession>
    <name>A0A8J5N2P8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin--tyrosine ligase-like protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Ttll5-L</name>
        <name evidence="8" type="ORF">Hamer_G001066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamyl-[protein] + L-glutamate + ATP = gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60144"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143622"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60145"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF145">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="883"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1042"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1101"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1190"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="883"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="909"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1042"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1190"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1251"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1266"/>
            <end position="1311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7172073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1335" mass="148378" checksum="4EC16595A9A9ECA7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4D6</accession>
    <name>A0A8J5N4D6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PFDN5-L</name>
        <name evidence="4" type="ORF">Hamer_G008558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4D6"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7173037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="174" mass="19412" checksum="F92E8389076447C8" modified="2022-05-25" version="1">MASSKGSGPQVIDISKLNLEQLTALKNQLDQELQFFNESLQQLKIAQLKFSESGECVEKVTPETKGKEMLVPLTSCMYVPGTIADAEKLLIDIGTGYYVERDVNGAKDYFSRKVKFVTEQMEKIQKIASEKSKLREVVMDMMEVKLDQQLAVIQQQQAEAEAAKAAAKAAEEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4H7</accession>
    <name>A0A8J5N4H7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Ncaph-L</name>
        <name evidence="12" type="ORF">Hamer_G007019</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4H7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="51"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7172780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="598" mass="67456" checksum="1879159A06DC1C84" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7L0</accession>
    <name>A0A8J5N7L0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mucin-19-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MUC19-L5</name>
        <name evidence="2" type="ORF">Hamer_G030401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007424">
        <property type="protein sequence ID" value="KAG7174682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7L0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35001">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35001:SF5">
        <property type="entry name" value="PROTEIN CBG01852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="322" mass="33669" checksum="6D2040549A9D29AB" modified="2022-05-25" version="1">MTFGPWDQARFQSALFDDHLQGSVLFGDHLQGSVLFGDHLQGSVLFGDHFQGSVLFGDHLQGSVLFGDHLQGSVLFGDHLQGRALFDDHLQGSVLFGDHLQGRALFDDHLRGTIFFIDHLQGSVHSSVTTSRECLFIDHLQELSLSVTTSKGVSSSVTTSRGVSSSVTTSRGVSSSVTTSKGVSSSVTTSKGVSSSVTTSKGVSSSVTTSRGVSSSVITSEGVSSSVTTSKGVSSSVTTYKGVSSSVTTSRGVSSSVTTSKGVSSSVTPPECVSSVTTSGNALFSDHLKEVSSSVTNSKNCLFSDHFQGYLFGDHLKGYPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7N4</accession>
    <name>A0A8J5N7N4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Down syndrome cell adhesion molecule-like protein 2-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Dscam2-L6</name>
        <name evidence="14" type="ORF">Hamer_G016457</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000017">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000104">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000093">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056754">
        <property type="entry name" value="DSCAM/DSCAML_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25059">
        <property type="entry name" value="FN3_DSCAM-DSCAML_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1277"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="76"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="174"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="269"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="356"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="455"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="580"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="744"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="846"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="970"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="1061"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="1158"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="889"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1363"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1444"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1534"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="907"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1458"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1542"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1609"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1627"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1657"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1695"/>
            <end position="1768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7174552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1830" mass="196490" checksum="D1D52D870E860F4A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8F2</accession>
    <name>A0A8J5N8F2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-coumarate--CoA ligase 3-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">4cl3-L1</name>
        <name evidence="6" type="ORF">Hamer_G015292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7175072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8F2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="55"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="466"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7175072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="553" mass="59478" checksum="DC219BFC0E7B4088" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8V4</accession>
    <name>A0A8J5N8V4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GATOR complex protein WDR59-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Wdr59-L</name>
        <name evidence="10" type="ORF">Hamer_G017050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7176075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000005">
        <property type="entry name" value="Zinc finger protein 14 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="988"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1016"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1044"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1072"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1201"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1287"/>
            <end position="1315"/>
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            <end position="1401"/>
        </location>
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            <begin position="1518"/>
            <end position="1549"/>
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        <location>
            <begin position="1922"/>
            <end position="1945"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="377"/>
            <end position="405"/>
        </location>
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            <begin position="1719"/>
            <end position="1767"/>
        </location>
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            <end position="356"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1723"/>
            <end position="1735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7176075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1945" mass="221377" checksum="04E11B9E050C58F6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCG6</accession>
    <name>A0A8J5NCG6_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7176874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
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            <begin position="58"/>
            <end position="75"/>
        </location>
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            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAG7176874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="8730" checksum="0F54262B5DA14B02" modified="2022-05-25" version="1">MSVTVATDDLDIDPSNVPTPELTPGDGSPDGRSVEVTPVLGAPAASLILVGISSPEASGRRSEDQSASLERRRQPELTSVEVSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NE69</accession>
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            <fullName evidence="8">Solute carrier family 35 member C2-like</fullName>
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        <name type="scientific">Homarus americanus</name>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="PANTHER" id="PTHR11132">
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    </dbReference>
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        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="44"/>
            <end position="68"/>
        </location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7177997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="349" mass="39298" checksum="789F0CAD5E06A98D" modified="2022-05-25" version="1">MEGNISSGQIDTTDGTNGIVNMTGLEVTEGRLTRRRGGRRLGQMIIHCIRTLILILMYYTCSIGLTFYQKRLFRDFKFPLTVVIVHLFIKFVLAGLFRVTYTLVTGIPRVTLPWDIYWRRVLPPGAAAGIDIGLSQWSLEFITVALYTMSKSTALLFILIFAIIFKLEEMVSSRIILVLITGGLFLFTYKYTQFNLFGFILVIIASLLSGLRWTLSQLVMQKSELGLSNPIDMVYHIQPWMTVSLLPLAIIMEGTAIAASEYGFRFTDSSDALHMWGRVMFGAVLAFFMEMGFLLCIIGIALHVVLKAIYPPKPPPPQQQHISLSPADGYQKVPLLSDTDGEEQELYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T2L5</accession>
    <name>A0A8J5T2L5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T2L5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035194921" evidence="1">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="75" mass="7147" checksum="2AC849A413D7A46C" modified="2022-05-25" version="1">MVKMMVVMMVVAGLLVAALALPDASPSRRGYGGYGGGYGGGRGGGYGGGRGGGYGGYGGGYGGYGGGYGGYGYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T5H5</accession>
    <name>A0A8J5T5H5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Vitelline membrane outer layer protein 1-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">VMO1-L9</name>
        <name evidence="3" type="ORF">Hamer_G014535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010116">
        <property type="protein sequence ID" value="KAG7173219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T5H5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.20">
        <property type="entry name" value="Vitelline membrane outer layer protein I (VOMI)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005515">
        <property type="entry name" value="VOMI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036706">
        <property type="entry name" value="VOMI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18841:SF0">
        <property type="entry name" value="VITELLINE MEMBRANE OUTER LAYER 1 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18841">
        <property type="entry name" value="VITELLINE MEMBRANE OUTER LAYER PROTEIN I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03762">
        <property type="entry name" value="VOMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51092">
        <property type="entry name" value="Vitelline membrane outer protein-I (VMO-I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035255538" evidence="1">
        <location>
            <begin position="18"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7173219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="221" mass="24181" checksum="469B07D646D0FDF0" modified="2022-05-25" version="1">MLRILLNTLLLTTTGYAAINSQYFLKFSSQKMVGGLLASLTSNRLIECASRCLANTSCQAYHWRRTVTSNNCDLLKYIDDYDSYTGTATGTDDCGVTGVELLCRTPEGNITSPITFDMNYTDGVKRKTATCTAGNFVNKFSSHMGPIRGADDDDGLNNLHLMCTDSFKLMSHDVGQVGTWAGWRSCLPGTFICGMKLRYEALGASSDNSCINEFIALCCFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T773</accession>
    <name>A0A8J5T773_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translocon-associated protein subunit beta-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SSR2-L</name>
        <name evidence="2" type="ORF">Hamer_G020211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009370">
        <property type="protein sequence ID" value="KAG7173579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T773"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861:SF3">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, BETA SUBUNIT PRECURSOR TRAP-BETA SIGNAL SEQUENCE RECEPTOR BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05753">
        <property type="entry name" value="TRAP_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="237" mass="26076" checksum="8E7EF8F8795D38A9" modified="2022-05-25" version="1" fragment="single">EYSISNHTEEPSCQLTTVLCVVLGGTTGRLHTHSVSCGAALLLSKMLCYLILALAFVGGVFSEGEGEERARLLAAKRVHNLYLVEGRDIVVQYSVHNVGQAAAINVQLTDAGFSTEDFDIAGGQLQVKFDRIAPNANVSHTVVVKPKKYGYFNFTAAEVSYQPSEESAEIQIGYTSEPGEGGIIAFRDYDRKFSPHVFDWMIFALLMIPALLVPFLMWYNIKSKYATVPRSKKGKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TBX9</accession>
    <name>A0A8J5TBX9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Actin-related protein 2/3 complex subunit 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Arpc4-L</name>
        <name evidence="12" type="ORF">Hamer_G018587</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ARPC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012106">
        <property type="protein sequence ID" value="KAG7171468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TBX9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7171468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="477" mass="55792" checksum="4D05EAE8A628962B" modified="2022-05-25" version="1">MSATLRPYLNAVRHTLSAAMCLQNFNSQVVERHNKPEVEVRSSKELLMTAVVVSRNEKEKVLIEPSINSIRISISIKQADDIERILCHKFMRFMMMRAENFIILRRKPVESYDISFLITNFHTEQMFKHKLVDFVIHFMEEIDKEISEMKLAVNARARECAMEYLKRVRKLGNVPYFSSVTSRDSLRSRKMNNAETTNGCIENVVWELLASWGTYYLHIPSAVKIGYYFFTLVALSMIKETVEVPHVETITGKYSFFNRIFVKKGWAFTVSTLILHQLTSITLLIEWKARLKQFVVRAITTTFFFYIWCVVIFNEIEKYTESCTYKNIKINLPKKECNRQEGHVYTALDISGHIYLLTFCVLVMMEESKEILYFLCLGGYLRGVSINTPEKIIWPKRGGKLSKSLRTRFTIVAPLVIFSFLCIFLLSLLWDAMLLVTMIYYHTILEKTLGSFLAVSMWCLLYKYLFPTIFGHRFFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5THF0</accession>
    <name>A0A8J5THF0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TipE-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tipE-L</name>
        <name evidence="3" type="ORF">Hamer_G009618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5THF0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017080">
        <property type="term" value="F:sodium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002028">
        <property type="term" value="P:regulation of sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031578">
        <property type="entry name" value="TipE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12335:SF6">
        <property type="entry name" value="PROTEIN TIPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12335">
        <property type="entry name" value="TIPE PROTEIN TEMPERATURE-INDUCED PARALYTIC E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16972">
        <property type="entry name" value="TipE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="340" mass="37867" checksum="5970FA952229246C" modified="2022-05-25" version="1" fragment="single">MEWDIIDAKLYPNIKGCGYPPSINCTLFNKNYSTPGRTFPCYYSKEQPLLVLTGVDIEGIKKDLIYAIIIPWGCFLVSVLYLLLTYAGMRKPDAEGDQPQEVSSAKASKEASNYSLRSIGKTINQGMNKLRGEPDDKGGHGGGNGGGVLSGFKRGQLTSHSMLGPKLLLAPASLPQVHPTRRTTLPPLERTPPLPRPARMHLIRDTLIRSDIGAKFLQEDELMAKMVFEDSEDDGEDEDGEDCTVFEMVKIALASKDKGRRERQVRKTTINEGKEDGVKNGSDGEEVVMEEVIEWKTMEYTDVKERKMKKRAGILKVLTTVFYPSQAKHPDNKDTESQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TK39</accession>
    <name>A0A8J5TK39_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Periaxin-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Prx-L6</name>
        <name evidence="1" type="ORF">Hamer_G018878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009009">
        <property type="protein sequence ID" value="KAG7173733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TK39"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35684:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="423" mass="49008" checksum="035C3DC7A8DEBF8C" modified="2022-05-25" version="1">MAYQCYQTPVLVNLSVDRYQCYQTPVLVNLSVARYQCYQTPVLVNLSVAECQCYQSQLVADLSVDRYQCYQTPVLVNLSVARYQCYQTPVLVNLSVDRYQCYQTPVLVNLSVDRYQCYQTPVLVNLSVARYQCYQTPVLVNLSVDRYQCYQIPVLVNPSVDRYQCYQTPVLIPVLPVPVLVNLSVARYQCYQTPVLVNLSVDRYQCYQTPVLVNLSVARYQCYQTPVLVNLSVERYQCYQTPVLVNLSVARYQCYQTPVLVNLSVDRYQCYQSPVLVNLSVDRYQCYQIPVLVNLSVDRYQCYQIPVLVNPSVDRYQCYQTPVLVNPSVDRYQCYQIPVLVNLSVDRYQCYQTPVLVNLSVARYQCYQTPVLVNLSVDRYQCYQTPVLVNLSFARYQCYQTPVLVARPNVTRTLCYIASVLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TK99</accession>
    <name>A0A8J5TK99_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial glycine transporter-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Hamer_G025231</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009024">
        <property type="protein sequence ID" value="KAG7173732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TK99"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="95"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="189"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7173732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="277" mass="30823" checksum="4A6A423F3366BBAD" modified="2022-05-25" version="1" fragment="single">SPLVKSFVAGSFSGTCSTILFQPLDLVKTRLQTTITIPSGGSVGMFAIVGKVVRNERLFGLWKGMTPSIFRCVPGVGLYFSSLHWLKTNFCEGQPGPFDALMLGVVARTITGVTMIPITVIKTRYESGVYSYGSMREAMCSIYRKEGTRGLTCGLIPTLLCDAPFSGLYLMFYTQTKKRVPQRYMEGNMAPPVHFTCGVLAGVMASAVTQPFDVVKTKMQLYPHKFTSFYEAVWYVNKKYGPQGFFKGLVPRMLRRTLMAAMAWTVYEQITKSFGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKZ8</accession>
    <name>A0A8J5TKZ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKZ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035296202" evidence="1">
        <location>
            <begin position="24"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="157" mass="17299" checksum="3FC9234E42F99DDF" modified="2022-05-25" version="1">MLPVQAAGVSFVMSLLTVIVAKGQTFTHSSHSPQTLPRPGVLQNHDAEESVSILYQQVTNKPNEPKVTYNIIEPPPLKCPGPSEFRDSSDNKCKVDYVCRFKNMMNNIHKRDIGRGSGTIEAADIIDTPPLPCPGLCEVRDENDECTIDFVCATRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLT6</accession>
    <name>A0A8J5TLT6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Cadherin EGF LAG seven-pass G-type receptor 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">Celsr3-L</name>
        <name evidence="26" type="ORF">Hamer_G000471</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000011">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000173">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.10:FF:000021">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF471">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 16" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 26" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1340"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1372"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1411"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1443"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1475"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1503"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="180"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="20">
        <location>
            <begin position="240"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="441"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="20">
        <location>
            <begin position="484"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="649"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="686"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="22">
        <location>
            <begin position="850"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="24">
        <location>
            <begin position="882"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="23">
        <location>
            <begin position="1143"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="25">
        <location>
            <begin position="1335"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1586"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1789"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1935"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1586"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1611"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1642"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1655"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1797"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1812"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1842"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1889"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="1942"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="852"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAG7177210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1974" mass="219993" checksum="DD30F677807F732A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TTQ2</accession>
    <name>A0A8J5TTQ2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Complex I-B8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase B8 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NDUFA2-L</name>
        <name evidence="16" type="ORF">Hamer_G000133</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TTQ2"/>
    <dbReference type="OrthoDB" id="10250268at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000127">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7176927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="95" mass="10555" checksum="EF750ED21FA117F8" modified="2022-05-25" version="1">MAVAGVLKFAPHLRELRLHLCQRSAASQGVRDFIEQNYVAMKKANPKFPILIRECSGIQPKAWARFEMGRESSASLDGLTAEQVAETIKKLNASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCC0</accession>
    <name>A0A8J5JCC0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044428">
        <property type="protein sequence ID" value="KAG7154514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCC0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="49" mass="6076" checksum="D5264ECB8143F270" modified="2022-05-25" version="1">MEFQRFWKVRNFLMKKKENKPQDPQELGLRLFIPSRNLCLGPFKRKRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCU6</accession>
    <name>A0A8J5JCU6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative filaggrin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCU6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="350" mass="38780" checksum="0DBF88C510D4A5CA" modified="2022-05-25" version="1">MSHTHVLSWPLINTWDNSLAPGTTHQHLGPLINTWGHSLAPGTNQHLGPLINTWGHLISTWDHSSTPGTTHQHLGPLISTWDHSSAPGTTNTWDHSSTPRTTSHLGPLINKHLGPLINTWDHHTWDHSSTPGTTHQHLHHSSTPGTTHQHLGPLIKHLGPLINTWTTHQHLGPLINTWDHSSTPGSLISTWDHSSTPGTTHQHLGPLINTWDHSSTSGTTHQQTPGTTHQHLTTHQHLGPLISTWDHSSTPGTTHQHLGPLKIPLRPGAFKTVWVTFCPRRNSQKRFLSHVRDLALCVREDEEDGTGEEKNEEGWRRDGRWGQVKKGGKEVGVAGEEDEGEEECDSEVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDT7</accession>
    <name>A0A8J5JDT7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G006491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDT7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="88" mass="10417" checksum="B048BE197B39F678" modified="2022-05-25" version="1">MEKLETIFLTNLWNDILERVNKTNKVLQSKDVDMLVAMNHLKSLKTYLQEIRDKFNEYELKGKSTHRCLGSDYSDANKRERKLSVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEG3</accession>
    <name>A0A8J5JEG3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit TIM14-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Tim14-L</name>
        <name evidence="8" type="ORF">Hamer_G021948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043253">
        <property type="protein sequence ID" value="KAG7154938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEG3"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7154938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="116" mass="12458" checksum="C4B08167B698B0CD" modified="2022-05-25" version="1">MASSVILVGLGLATVGFGARFVLRTMPTLGKKMAEAVNGIPKLDGKSLVNSKYYKGGFEPKMTKREASLILNISPNASSLKVKATYKKMMLVNHPDRGGSPYISAKLSEAKNLLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JH24</accession>
    <name>A0A8J5JH24_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038245">
        <property type="protein sequence ID" value="KAG7157036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JH24"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="173" mass="18975" checksum="29F6A6BCAAD5DCC2" modified="2022-05-25" version="1">MTGSVVTDGGGDVIKGYTISAAGGRRRVSLNWTFLHSTCTKWWAFGCLFYFLWWLPWPILGMVAMDSTTTLTMMIMAVDDVVIMAMADVVILAVEDTMILAVEVMVFLAMEVMVILAMEVMVILAMAVMVILAMEVMVFLAMEDKVIMFTGDTVMATEGTVDMVVIDMVVGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHQ5</accession>
    <name>A0A8J5JHQ5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NHP2-like protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hoip-L</name>
        <name evidence="4" type="ORF">Hamer_G025427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040325">
        <property type="protein sequence ID" value="KAG7155815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHQ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7155815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="76" mass="8332" checksum="A03D0D71DF74997E" modified="2022-05-25" version="1">MIVMAADAEPLEILLHLPLLCEDKNVPYVFVRSKTALGRACGVARSVMACAILSNEGSQLKPQITIMHQEIEKLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHX7</accession>
    <name>A0A8J5JHX7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA-processing protein FCF1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FCF1-L</name>
        <name evidence="9" type="ORF">Hamer_G019976</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044137">
        <property type="protein sequence ID" value="KAG7154558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHX7"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000004">
        <property type="entry name" value="rRNA-processing protein FCF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="8">
        <location>
            <begin position="66"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7154558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="194" mass="22639" checksum="F8EE0995C4936298" modified="2022-05-25" version="1">MPKSKKTRKFAVMKRMINLNDPRLKEEDRKTKKVKKPDPHEQKVNEAPQYSSALFFEYNTQLGPPYRILIDTNFVNFAIKNKVDIVSGMMDCLYAKCIPYVTECVQGELERMGEKYRLALKVIKDSRIETLPCLHKGIYADDCLVQRVTQHKCYIVATCDRDLKRRIRKIPGVPIMCVSQHKFVIERMPDAPQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JII3</accession>
    <name>A0A8J5JII3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sarcoplasmic calcium-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Scp-L</name>
        <name evidence="5" type="ORF">Hamer_G020359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036764">
        <property type="protein sequence ID" value="KAG7157816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JII3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7157816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="215" mass="24205" checksum="C80F1798376F9E67" modified="2022-05-25" version="1" fragment="single">NNVAPTLAATPLSLTPGTSPDPSSPGEVRWAEFCSHAQTPFWRKKMRTHHRLFDVNKDGVVSWDDFEALIGKFKELGHLSPKEVGKLTDALRHVWEEEWGASSDPYIFIGQEQFLSQMEHVINTKELRKRVASPLPYFFKAVDTDGSGEISVAEFKMFYACLGLSEEAATESFAAIDINGDGKLSMKEFIKLGREYFLAEDETRPSKLFWGPLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIN4</accession>
    <name>A0A8J5JIN4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Tigger transposable element-derived protein 1-like 274</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TIGD1-L274</name>
        <name evidence="2" type="ORF">Hamer_G009492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIN4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="88" mass="10335" checksum="17A96721C70C9748" modified="2022-05-25" version="1">MDPKKRKSCKWDYGKVNRDILSLARQAGFDELESEDIEQVLASHTEEFTNEDLQQLTEHSPVEDDDDEEEEPQRTLTTKRLAESFNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIR6</accession>
    <name>A0A8J5JIR6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Betaine--homocysteine S-methyltransferase 1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Bhmt-L1</name>
        <name evidence="10" type="ORF">Hamer_G021631</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035455">
        <property type="protein sequence ID" value="KAG7158355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIR6"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000003">
        <property type="entry name" value="Betaine--homocysteine S-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051524">
        <property type="entry name" value="BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46120">
        <property type="entry name" value="BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46120:SF4">
        <property type="entry name" value="HCY-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="9">
        <location>
            <begin position="34"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7158355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="396" mass="44354" checksum="4B5CFCCBBAA23BA8" modified="2022-05-25" version="1" fragment="single">EVEEEEEMEVEKEVEAVKEVEEEMKVEEVEEEEKKGLLERLREGPVIGDGGYVIELEKRGYVTAGLWTPEATVEHPEAVRQLHREFLRSGSDVIQSFSFFASGDRISDTKNKFTGEAINQAACNLAVEVAREGDALVCGGVCQTPAYRKGATKNETRTLFRNQMQVLVDNRADFLLCEFVEEIELAIEVAKTFGLPVAASMCIGEKGSHDDVSLGQCAVRMARAGADVVGLNCHHAPMTVVENIKTMKKALQEAGLEPFLLTQPCGYHVDEAEKMGYLEIPEYPLAMEPRTITRWDCHRYARAAYDAGVRYLGGCCGFQPYHIRALAEELLPERGGRRAPAMDKHYPWGGGQVHSFFTMIRRRSTRDYWENLQPATGRPRSSAFSKCDTDYTVVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIU5</accession>
    <name>A0A8J5JIU5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">40S ribosomal protein S9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RpS9-L</name>
        <name evidence="14" type="ORF">Hamer_G016642</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIU5"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10 14" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="13">
        <location>
            <begin position="7"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="12">
        <location>
            <begin position="109"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7159242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="194" mass="22582" checksum="EB7B89B23E640696" modified="2022-05-25" version="1">MVNHRVQLVQSKRYSTPRRPFEKPRLDQELKLVGEYGLRNKRELWIVKMFLAKIRKAARELLTLDEKDARRLFQGNALLRRLVRTGVLEEGRMKLDYVLGLKPEDFLERRLQTQVFKLGLAKSIHHARVLIKQGHIRVRKQVVNVPSFIVRLDSQKHIDFSLKSPFGGGRYGRVKRKNMRKGGSKADDGSGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JK33</accession>
    <name>A0A8J5JK33_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Hmgcll1-L</name>
        <name evidence="8" type="ORF">Hamer_G021440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010040315">
        <property type="protein sequence ID" value="KAG7155818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JK33"/>
    <dbReference type="OrthoDB" id="1905920at2759"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000038">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000138">
        <property type="entry name" value="HMG_CoA_lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01062">
        <property type="entry name" value="HMG_COA_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="61"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7155818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="353" mass="38103" checksum="783DFD68297F8A0D" modified="2022-05-25" version="1">MSRRQASRRSFTMATLACRVNVISALKTFCRNYGASAVSFGKSQYVEIRGAHVRPEYPKQVKIVEVGPRDGLQNEKVHVPTNVKIEFINRLSQAGHQSVEVTSFVSPKWVPQLADHAEVLRGIHRVKNVSYPVLTPNLKGFEAAVAAGCEEVAIFGAASESFSQKNINCSIAESLTRFQDVMTAADKLGIPVRGYVSCVCGCPYEGLVDPKAVAKVAYTMYQMGCYEISLGDTIGVGTPGSMRRMLEEVMNLLPPDVLAVHCHDTYGQALPNILTALQMGISVVDASVAGLGGCPYAQGASGNVATEDVVYMLNGLQIETGVDLDRLIDAGNYICKVLNRPNFSKVSCAKTKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKP3</accession>
    <name>A0A8J5JKP3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G031489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039322">
        <property type="protein sequence ID" value="KAG7156223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKP3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="376" mass="42955" checksum="7DC23294C1266D8C" modified="2022-05-25" version="1" fragment="single">MVRVLGPGAVLDTRTMTRATTAALEQLGKGRKQLEQGRKQLEQGGKQLGQGGKQLEQGGKQLRGNQKETEYRNLRHEYCFGPIVLETERAWSTKVHQRLQIIELLVPASQHSSLERNYTDKELINDMIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTKAAGHVYSHERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JL65</accession>
    <name>A0A8J5JL65_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035946">
        <property type="protein sequence ID" value="KAG7158036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JL65"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="251" mass="28840" checksum="E69364F780C78367" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPTINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLN4</accession>
    <name>A0A8J5JLN4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Down syndrome cell adhesion molecule-like protein 2-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Dscam2-L12</name>
        <name evidence="4" type="ORF">Hamer_G024954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034681">
        <property type="protein sequence ID" value="KAG7158553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLN4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="64"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="174"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7158553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="259" mass="27720" checksum="F849F68DF6D1FA3C" modified="2022-05-25" version="1" fragment="single">PSLLSPTDGKYQALLDGRLLVHEVKAADSYATYRCRVLHTLTSTTAASNTARIIVHDPRERQAPRMVTKSATVKLSDSKPLVLPCVANAHPPPKYRWWQERGGEKIPIITSSTGVVGSGRTSEMGGTRTWGNGGVMLLDPNTHASSDDTTKLVCEASNEAGRATMEIRVERAVPVIAHLTPRVVVVDAGGVGVLRCQVPGPHPHSISWYKDGHVITPAGRIGITEGGSVLEVRGVGRADAGMYQCFVRGDEDTIQDAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLR9</accession>
    <name>A0A8J5JLR9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Actin-3-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Act3-L4</name>
        <name evidence="12" type="ORF">Hamer_G006696</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLR9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0558">Oxidation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7156703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="379" mass="42021" checksum="48201051DD274AEE" modified="2022-05-25" version="1" fragment="single">MAHIITMCDDEATALVVDNGSGMVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEESPVLLTEAPLNPKANREKMTQIMFETFSTPAMYVAIQAVLSLYASGRTTGIVLDTGDGVTHTVPIYEGYCLPHAILRLDLAGRDLTAYLMKIMTERGYSFTTTAEREIVRDIKEKLCYVALDFENEMNLAAASSSLEKSYELPDGQVITIGNERFRCPESLFQPSFVGMESVGIHETVYNSIMRCDIDIRKDLFANNVLSGGTTMYPGIADRMQKEITALAPSTIKIKIIAPPERKYSVWIGGSILASLSTFQAMWITKEEYDESGPGIVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMB6</accession>
    <name>A0A8J5JMB6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pogo transposable element-like 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Pogo-L34</name>
        <name evidence="4" type="ORF">Hamer_G007634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMB6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018586">
        <property type="entry name" value="Brinker_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09607">
        <property type="entry name" value="BrkDBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="TrpR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="59"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7160872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="243" mass="28261" checksum="34C61A98EA410E47" modified="2022-05-25" version="1">MAPIVKRRRYEACFKLKVIAYAQSHNNCAASREYGVTEKMVRDWRSKEHLLRSMPRIKCAMRRGTAHWPILEKHAVDIVHEQRQNGYIVSRNMIRIWELKWAKQNQEHSKDFKATASWCSRFMERSNLVLRQKTKIAQKLPADLNCGNMRAPELDVLCDFVIKAWNDINVETGIKSFKKCGISNSMDGMEDDMLWEDEDETEAEATSSDLEFDPYDDATINVSQDVLEELMISDVDDVDFEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNE4</accession>
    <name>A0A8J5JNE4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027843</name>
        <name evidence="2" type="ORF">Hamer_G028416</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039216">
        <property type="protein sequence ID" value="KAG7156234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010022168">
        <property type="protein sequence ID" value="KAG7166878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNE4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="68" mass="7718" checksum="04F1BF4F4FD3B566" modified="2022-05-25" version="1">MFPLATISPKTACDWSGKHAHQTTMNPIRVDRGSCSVTTRTIRSVYKIYLLLENSIATIPFLLQFYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNT4</accession>
    <name>A0A8J5JNT4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNT4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035326501" evidence="1">
        <location>
            <begin position="21"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="368" mass="42374" checksum="0A6352DF3A91BA47" modified="2022-05-25" version="1">MYWPAVMIAIALGHLGQVLTTVQDCTSETYLARNAAYECFKMEKSVGFKLKGNDTWSVGLYLKINSSRLLQINTSLSGNTTMKLLDDDDDDSSKLMCSNCTINQSEVFTPGVFTHFRLKPAKKAGIVLEWYRDNTTNVRKVTFPINEGFIFKDKSKLSIQPIAFTDGVYLRTNCFKVVYSIIFRQTEEGQEKQKYQCHEYNSDNFGTLTHHNTTNTCHLNSEDEIIPHEKSTIFINTINRSTIFVNTINRSTIFINTINRSTIFINTINRSTIFVNTINRSTIFVNIINRSTIFVNTINRSTIFINTINRSTIFVNIKKSNEKHRHWHMCISDNWLFASHWLEPLETSNQPLNCQISPDLPPFIHHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQA6</accession>
    <name>A0A8J5JQA6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Macrophage mannose receptor 1-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Mrc1-L3</name>
        <name evidence="4" type="ORF">Hamer_G021283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031318">
        <property type="protein sequence ID" value="KAG7160323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQA6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45784">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45784:SF3">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER K-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035177364" evidence="2">
        <location>
            <begin position="21"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="30"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="152"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7160323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="283" mass="32478" checksum="EB47848B401656DA" modified="2022-05-25" version="1">MTPKLFTLLVLAGVVSFVAGQDCFPPYVKLGGQCVFVEYDTQKSWQEAREFCASLAGDGTAGDLATFPTCDEYTTFVRYLALNVPVNTTVWVGAHSLFTPNMWQWLTEESLQTGVPFWAYPEEYNGTENCAAASGSYYYRLVDAHCDLTKLIGNNCYVFEDHVESWERAEQKCREEHDHYAGLLYYPSSCEEFTHMAHHLEADERRKQYWVGGIDVSGKEEWTWVEGGIIPSGPPYWASGEPSHQHDNRPRKHCTIMDPSMRYYLRDEHCNDYHPYICKLTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQW2</accession>
    <name>A0A8J5JQW2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037379">
        <property type="protein sequence ID" value="KAG7157584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQW2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="93" mass="11033" checksum="4E47B18146D5A5D3" modified="2022-05-25" version="1">MAIWRRVRNSMSVLLLLIVILYIGYCTEELYARIQNHRKLQRLTDYEKEIDELTKMLGEYKNDASSVQRSIKLLQEAFGHIKLNQEAKTMSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JR51</accession>
    <name>A0A8J5JR51_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane cell adhesion receptor mua-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mua-3-L</name>
        <name evidence="9" type="ORF">Hamer_G012706</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1383"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1338"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="542"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="659"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1447"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1511"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1565"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1447"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1472"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1574"/>
            <end position="1584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7160165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1759" mass="187011" checksum="50EFCDCF49EF27F7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRH9</accession>
    <name>A0A8J5JRH9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G001645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRH9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7160405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="221" mass="23836" checksum="CC3126156A8E43A4" modified="2022-05-25" version="1">MFRMERGRIELAVVFLIWMVPTVIAMVLVHVFGVAAVVAMGVFFVIGILVSAFVKSTGKCQNLTESQPVQEQSPQNVEEDCPPSYEVVTSKPPPYSLLYVSDSLPGGSREDVESASSSAHMLPDAQHNKNVEFCHTWTVTDPESSPPSYPEAVNSSFGGIPHTTSNTTPTSTLTSETTPVIYPSTSTLTSYFTSRTTTPSSTTTMTTCPSSTTCVKVHLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRJ6</accession>
    <name>A0A8J5JRJ6_HOMAM</name>
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        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G004283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7159613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19497" checksum="6C5E3184C3789B85" modified="2022-05-25" version="1" fragment="single">EHLQVIWHSNKKAWIMTVLCQNYMVGYHSKHLKAYAEKQNISNKFLLICVHNFCSFPDVVTLHRDITSISQETGFQEVDEENVAEVLDSYSELSTEDLLLLEQQQRMEESTGEEENPAPMTLTLKVLSTAMDRVNTAMKPLAENDPNINRSSSVRAVVKGMLCYKELYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRW9</accession>
    <name>A0A8J5JRW9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pogo transposable element-like 37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Pogo-L37</name>
        <name evidence="4" type="ORF">Hamer_G002088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="3">
        <location>
            <begin position="151"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7163035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="301" mass="34633" checksum="FDA0DCCDE9859583" modified="2022-05-25" version="1">MSRFCNKVNGETGDRRQTGFNRGNEGGPEPQKEKIPDERRGVPLYMPDDLEDDKLFDTGIQVGQNFERYSSMTVQCDMPKNHGNRATERNFGPPPTEKMIRQWRKQEEELKKANKQKHNLRTVPSKWPDLEENLKTWILDQRNLGLAVTTKMIILEARRTENTKRLAKGLNIQLAVIPGGLTSQLQPLDVGFIKPFKNNMREQWNKWMTEGNHDMTPTVRMKRPSIPEVCEWVLKSWCDIKTKVIVKSFKKCGISNAMDGTEDNLLYETDSSDDDDDISSRDDSELGDESNSDDFSGFEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTI4</accession>
    <name>A0A8J5JTI4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface glycoprotein 1-like 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">olpB-L16</name>
        <name evidence="2" type="ORF">Hamer_G030846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030919">
        <property type="protein sequence ID" value="KAG7160723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTI4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="551" mass="59571" checksum="6BF2A77A14B7542C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JU24</accession>
    <name>A0A8J5JU24_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tigger transposable element-derived protein 1-like 150</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Tigger transposable element-derived protein 1-like 151</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TIGD1-L151</name>
        <name evidence="2" type="synonym">TIGD1-L150</name>
        <name evidence="2" type="ORF">Hamer_G030929</name>
        <name evidence="3" type="ORF">Hamer_G031570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033804">
        <property type="protein sequence ID" value="KAG7159106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010025658">
        <property type="protein sequence ID" value="KAG7164100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JU24"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7164100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="155" mass="17984" checksum="B932E81CD02E998E" modified="2022-05-25" version="1" fragment="single">WKEVTVRCLCAAWRPLWPECVLQRDFEGFEESEEEAVVHEIVALGNSMGLEVDDDDVEELVEEHSKELSTEELLELHKEENETLKRSLTSEESGEEEDKEESRIIPAKDLEDAFFCWSKLSKLAEDYHPDVGSVQKAISVFNDNVMNYFWKVQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUV1</accession>
    <name>A0A8J5JUV1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MRG/MORF4L-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G005160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUV1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="110" mass="12870" checksum="A86CD2360F466E95" modified="2022-05-25" version="1" fragment="single">SVVDESDKLPFPNDENEFNLPEVEFSDLLDERSKPDIKEDNKDEKEIRARGRPPKKDPDKDYKDEGVRRERARELRDDDDDTPRKPGKRGRDSKPSSPAHTPTSNKRRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVV6</accession>
    <name>A0A8J5JVV6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tenascin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Ten-m-L1</name>
        <name evidence="18" type="ORF">Hamer_G010866</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Synapse</location>
            <location evidence="13">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tenascin family. Teneurin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097060">
        <property type="term" value="C:synaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099559">
        <property type="term" value="P:maintenance of alignment of postsynaptic density and presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048790">
        <property type="term" value="P:maintenance of presynaptic active zone structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034116">
        <property type="term" value="P:positive regulation of heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001941">
        <property type="term" value="P:postsynaptic membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097090">
        <property type="term" value="P:presynaptic membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034110">
        <property type="term" value="P:regulation of homotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000331">
        <property type="term" value="P:regulation of terminal button organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051124">
        <property type="term" value="P:synaptic assembly at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016200">
        <property type="term" value="P:synaptic target attraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048499">
        <property type="term" value="P:synaptic vesicle membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000021">
        <property type="entry name" value="Teneurin transmembrane protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000013">
        <property type="entry name" value="Teneurin transmembrane protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000033">
        <property type="entry name" value="teneurin-a isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.180.10.10">
        <property type="entry name" value="RHS repeat-associated core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057627">
        <property type="entry name" value="FN-plug_TEN1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056823">
        <property type="entry name" value="TEN-like_YD-shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056822">
        <property type="entry name" value="TEN_NHL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056820">
        <property type="entry name" value="TEN_TTR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028916">
        <property type="entry name" value="Tox-GHH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF72">
        <property type="entry name" value="TENEURIN-M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24329">
        <property type="entry name" value="FN-plug_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25021">
        <property type="entry name" value="TEN_NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25023">
        <property type="entry name" value="TEN_YD-shell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15636">
        <property type="entry name" value="Tox-GHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25020">
        <property type="entry name" value="TTR_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="6" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1827"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1891"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="2055"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="143"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="293"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="653"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1248"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="3960"/>
            <end position="3986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="662"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="766"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="874"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="926"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="944"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="981"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1014"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1028"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1038"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1256"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1317"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1330"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1362"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1476"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1505"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1563"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="3962"/>
            <end position="3986"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1831"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1848"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1913"/>
            <end position="1922"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="2059"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="2081"/>
            <end position="2090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00084038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7162194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="3986" mass="437135" checksum="FD0FD7AD64BB60FF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWC1</accession>
    <name>A0A8J5JWC1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G008028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWC1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="101" mass="11853" checksum="1045B783F6DEB4D4" modified="2022-05-25" version="1">MGGDEELWSSRMLIDAQEAFFNIKDKKLLLLQPLILDENPKDLQNNQTENVQQFCRAYSDIWLPHLTTNKKSRANLLIFGHRELRRICGPISGVEKNSWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWN4</accession>
    <name>A0A8J5JWN4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neural-cadherin-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CadN-L3</name>
        <name evidence="6" type="ORF">Hamer_G002763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWN4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="4">
        <location>
            <begin position="238"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="450"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7163563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="523" mass="56126" checksum="6EFBAA41FE74FDD9" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXY4</accession>
    <name>A0A8J5JXY4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Centromere protein F-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Cenpf-L2</name>
        <name evidence="2" type="ORF">Hamer_G002244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXY4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="326" mass="36033" checksum="137B2C82B95262EA" modified="2022-05-25" version="1">MQVKAAESESNSLCKELREVKQQTDHWQKRFSEKNTEAEEQAAKQIELMKKMLDLEEENDNMKSKVLLLQGRIKRLKSEKNGKEAPDGRADKELRNQNVKSDASSSSANNPQKEATNSLGLQGSDSQEIVESSLTQVSRNSTVSQITRRAVTRRASTLLSVPTAPKESSTKISSKSPKEKSTKPQRSSAVSMDEYSTHNSSQSDRLRTLRTRGRSTSTVTLLGDETMKQAIKRVSSSTSVTKDKKKRLNDLSSGVESPGVLQRSTTLAKKMNPKEMLQESGPLRSLNPNSPVRPSTRRAPTHRTSSVGTRTRASSSTARGDDCKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYM1</accession>
    <name>A0A8J5JYM1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYM1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="172" mass="18837" checksum="BAD227770F02E20E" modified="2022-05-25" version="1">MVICIAHNIRALSVMLETTQTSTPKAPPTTLNSSVADILARVVEFAEMDVASKTMTPRPPNARDASRHPQPTSSTLLLISPSPTDIHSCSVNDKKRFSALEGSSSASDNDEEAQQPKKQSSPPSLPKAGRLSDKPDKLDEEHKNTPQKLTREDDEETTSDRKRRCTLDDTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZV3</accession>
    <name>A0A8J5JZV3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZV3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="219" mass="24463" checksum="FCC0C1426FC830FB" modified="2022-05-25" version="1">MASGPGSMSRNNACIKGPGIAHQQERALGTNSFKHENWAYPPALPVMGNSVSKKADLLTPLNSLLTRSLTLHMSPQLYSMDSCQEMSLEAEGHFQAARSWDLQSRALPVSRTRPDTAFAFAGHSKKAAWATWNAFRSDNRLPQSGFHPKVSCLVVSCRHRRDSSCCSMTVRAHAVTNVLRKKSLFSRKSRLRISHQHEQLWSSNKRAAYQADIFVDKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K008</accession>
    <name>A0A8J5K008_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposable element Tcb1 transposase-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Tcb1-L6</name>
        <name evidence="3" type="ORF">Hamer_G017224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K008"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="74"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7164834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="188" mass="21563" checksum="D33DC272B8D19505" modified="2022-05-25" version="1">MSRRVTTRDDIAAVIALYKANHVLREISAQTGVALRVVQNLVKRFRDLGEDELPAPLPKFGRPKLLSPRTLLVISRQVRSNPSLTAREVKERNPRLLSHVSLSCVQQALHNDLGFKSFRAHRKPLLTKRQKKNRVKFCKKYEVWDLETWRSVLWSDEATFSVTGSNGGRVYRPPPLRRAPPTIQCKDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0G7</accession>
    <name>A0A8J5K0G7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7165896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0G7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="286" mass="33281" checksum="18B22CF323C101CB" modified="2022-05-25" version="1" fragment="single">MITFGDWGQAELLKTVTSINKFPLQVEIQELIGEVFVVKKLKKRDEKSTSALSRLSDGRVVALWSPSRTGNNVVYGIISYTELEHMKNNKMEELLGNIVVQRKLSRPDGGATSALVGFFYELLKEINHLEKKKNDRTSKAALAGYPRNPPSEVLLGGSPIPVRPCEKTPTKCYKCQSYGHLTKKNQAQRSVPVWDTRTPHVRRPKIYKKQERTKAEEPERDKREKEQQEPQEQEKERQEQEREKMTLIISEFINFFKSLPSLEDQEKLVFKKKERKKKEEIRRTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K142</accession>
    <name>A0A8J5K142_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020459">
        <property type="protein sequence ID" value="KAG7168210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K142"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="179" mass="19323" checksum="A3AAD3E333A0D7CB" modified="2022-05-25" version="1">MGGSISDTPVVKLSIKRLSSGSLPSEGVAEVFGVGVEGVARGSVARRLCGSFLREVDKQLQLLEDNDYNAERSRIAVRGVKSFSAPYEQLLCERRKTAKQQTLDVFFKSTPKKQSEDTEPQPSTSGIRRFFLPSHATKTAPDDDDTDDDDDNSQLLSGEVPNSTTAGTVETLKGGVSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1U3</accession>
    <name>A0A8J5K1U3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G021799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019050">
        <property type="protein sequence ID" value="KAG7168782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1U3"/>
    <dbReference type="OrthoDB" id="6361604at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7168782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="294" mass="32609" checksum="25EEA007A0B48C78" modified="2022-05-25" version="1">MTPVLRMRHNEPTGVKKTLSYLTFVNGCVLLLLVCLTPAAGDAPTPVGDSSAPPGPQCLHDDPRCPSSSSSINDSIRNPDKDAEEGPSHTETDSPQDGDEPELMNFINVDKRTMEYEHEEIQDSPDEVERVLSCIFTSVPFIGGKWLEKIVRNSYSDATLLEASHRFLDGGEFLSKFISLGTSSPAGKMLEIVSSCFEDDEMVDYKGEYLSGYYQDEDEPQNPYQNPIPVPDRNSRPERTQYDLPGAPTSSPLQHTRRKRRLARTFGADSLLGFNLLGTLVVCSLVVYLVYLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2D0</accession>
    <name>A0A8J5K2D0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface glycoprotein 1-like 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">olpB-L15</name>
        <name evidence="3" type="ORF">Hamer_G030173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024369">
        <property type="protein sequence ID" value="KAG7165283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2D0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="247"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7165283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="689" mass="78939" checksum="40C7DCD0AF9BBD8D" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2P7</accession>
    <name>A0A8J5K2P7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc finger BED domain-containing protein 5-like 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Zbed5-L14</name>
        <name evidence="1" type="ORF">Hamer_G011216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2P7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="8163" checksum="E891573671020247" modified="2022-05-25" version="1">MATSVAKKRKYIDGYINYGFTSILADGIEKHQCVLCFKVVGNDSMRPSKLKHHLMTIHPQYAERHQFLQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5S2</accession>
    <name>A0A8J5K5S2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Macrophage mannose receptor 1-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Mrc1-L7</name>
        <name evidence="4" type="ORF">Hamer_G005449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="4">Heart &amp; testis</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5S2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035317883" evidence="2">
        <location>
            <begin position="26"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="60"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="205"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="337"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="420"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="563"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="706"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="851"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7167113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1029" mass="115468" checksum="90DCFFEEC5D8BE3A" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6G9</accession>
    <name>A0A8J5K6G9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G028069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019656">
        <property type="protein sequence ID" value="KAG7168671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6G9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="79" mass="8682" checksum="9320C3535F069EA6" modified="2022-05-25" version="1" fragment="single">YQQGVETSQQQLTSSPLWLHNEYHTHPAEDRQISSSTSDNLGLEKCWASSNHLVLRYTIPGTASLLAGRTASPTSLLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K759</accession>
    <name>A0A8J5K759_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Cyclin-K-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022770">
        <property type="protein sequence ID" value="KAG7166104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="216" mass="23123" checksum="E4BF84310040E022" modified="2022-05-25" version="1">MPGSTPRRPTTPTQTSSTAPPPAKKAKKEEVKSSPVKTESTTTPSQPYQYPYQYTNYPPSYPSQSSSQGTSTATTQRYPYTYPPSTTQGPPPQAPPPQAPPPTYQPPQRHYPPPAAATSQAPPPHYASQPPPSHYSTTTHPASTYHPPPTTPHYPTPPTNQPPPQSHYPPPPHSSTSSSYYAPPPASANPPSYPGAGPSSTYPPPSSYSHSSSRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K9V1</accession>
    <name>A0A8J5K9V1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Hamer_G018567</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010012106">
        <property type="protein sequence ID" value="KAG7171451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K9V1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035339322" description="Carboxylic ester hydrolase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="27"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="559"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7171451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="611" mass="68307" checksum="F9DB03C8E84C9CEE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KA16</accession>
    <name>A0A8J5KA16_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Jerky protein-like 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">jrk-L24</name>
        <name evidence="6" type="ORF">Hamer_G030513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014904">
        <property type="protein sequence ID" value="KAG7169968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KA16"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="4">
        <location>
            <begin position="331"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="636"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7169968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="679" mass="75312" checksum="70DA1BF0484510DB" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KDD5</accession>
    <name>A0A8J5KDD5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5-related protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Cyb5r-L2</name>
        <name evidence="7" type="ORF">Hamer_G019609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016480">
        <property type="protein sequence ID" value="KAG7169465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KDD5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053100">
        <property type="entry name" value="Cytochrome_b5-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16740">
        <property type="entry name" value="CYTOCHROME B5-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16740:SF1">
        <property type="entry name" value="CYTOCHROME B5-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="60"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7169465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="198" mass="22620" checksum="F1941241162D004A" modified="2022-05-25" version="1" fragment="single">EMAPRQDLKQDSHKSKGNQNWLSHTGFLHYPTGRDQLVKTTHGWMNGKRIDDDVGPYWRIHNKLYDMTDFIEKHPGGQDWLLATKGTDITEAFESAHIGTAAENLLHKYYVNDILTPRNSPYTFHENGFYKTFKRKVQPVLKRVGKGPTLYMRFIQDSLALTFVALMIASVITQSYTKIIFAGVMVTNKINDTVLGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KED7</accession>
    <name>A0A8J5KED7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G018052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015512">
        <property type="protein sequence ID" value="KAG7169795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KED7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7169795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="202" mass="22688" checksum="C77D1BFA7AA8E9B8" modified="2022-05-25" version="1">MTTTLGIRTGVTASTITPQHLTAALQQNGGGRITPSGLPLDQKITVKRVMRSSPDSDDTGNTEEGSGESWRREDDYMVSDKCENKYYGAVPVSTGPAKWYDRYVEMVQRTFPRFFPWVEEGPCTEETGRQVMKLVGLLYLNVLIFDLVLVFSLGELEVHSPAASLFSIMLFLTILLILLQISRKPQNRYFHVPQHTVLPYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KFV4</accession>
    <name>A0A8J5KFV4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome-binding protein 1-like 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Rrbp1-L13</name>
        <name evidence="3" type="ORF">Hamer_G028505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014011">
        <property type="protein sequence ID" value="KAG7170518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KFV4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052671">
        <property type="entry name" value="Acrosomal_SP-10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17571:SF34">
        <property type="entry name" value="ACROSOMAL PROTEIN SP-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17571">
        <property type="entry name" value="URINARY PROTEIN RUP /ACROSOMAL PROTEIN SP-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="698"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="790"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="458"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="737"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="791"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="996" mass="115260" checksum="F1760108A3427FBD" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KG46</accession>
    <name>A0A8J5KG46_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Glutamate receptor 2-like 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Gria2-L14</name>
        <name evidence="14" type="ORF">Hamer_G025651</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019044">
        <property type="protein sequence ID" value="KAG7168789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KG46"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="13">
        <location>
            <begin position="54"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7168789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="173" mass="19498" checksum="6821A3C01D363C91" modified="2022-05-25" version="1" fragment="single">EADFAIGPFGISASRAEVVDFTWPLFVTYSRIMAGKRGVEADPWGFLLPLAPLVWVAILTALVVLPVVMFLFSLFCSLLSNPPNESATDAFSMFRVLLQQDISFPDDWWWERVLLGVWMLTTLVLTRSYAGNLMSLLAVRHIPQPYQTLQDVLDDPSVIMIWQSGSTNEHIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KNB0</accession>
    <name>A0A8J5KNB0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G013401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KNB0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="82" mass="9107" checksum="3D73939BE0A4CDD8" modified="2022-05-25" version="1" fragment="single">PTSALEQQQRHDTDHLLSRHGGDREAETDSSRALGSEGGRSSGRLEHHQTLATRIQLKGMHGGVLTEVVIDELWLTPITELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJY7</accession>
    <name>A0A8J5MJY7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="3 8">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Esd-L</name>
        <name evidence="9" type="ORF">Hamer_G020055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="3 8"/>
    <dbReference type="EMBL" id="JAHLQT010045843">
        <property type="protein sequence ID" value="KAG7153997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJY7"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7153997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="284" mass="31231" checksum="808540F906CC6E5E" modified="2022-05-25" version="1">MTTIKEESSNKAFGGWQKVYSHDSKELGCHMKFGVFIPPQADSEQVPVVYWLSGLCCTEQNFITKSGSQQHAAKHGLLVVAPDTSPRGCNIEGEEDSWDFGTGAGFYVDATEEKWKTNYRMYSYVTKELPAVIAANFKVDSDKAGIMGHSMGGHGALICAFKNPGQYKSVSAFAPICNPVNCPWGVKAFTGYLGADNKDAWKTYDACDLAKNYNGPPLEVMVDQGKADNFLTQGQLLPDNLVAACANGGVPIVMRMDEDYDHSYYFISSFIGDHFDHHAKFLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLB4</accession>
    <name>A0A8J5MLB4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040727">
        <property type="protein sequence ID" value="KAG7155738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLB4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="10176" checksum="1E6B6876D6A9730D" modified="2022-05-25" version="1" fragment="single">MNRGNRIWEFWNKFGNQDGQAALARLEEMQRQRHGRRLRRIVGDRMNPFTAMSDAEFVDRFRLRKESVNSIIQKIQEQLAVANDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLP9</accession>
    <name>A0A8J5MLP9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Tigger transposable element-derived protein 1-like 293</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TIGD1-L293</name>
        <name evidence="4" type="ORF">Hamer_G024949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040055">
        <property type="protein sequence ID" value="KAG7156113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLP9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7156113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="257" mass="28598" checksum="E809D1A604AC6B4E" modified="2022-05-25" version="1" fragment="single">RARRVLTLNEKNEVLKQLDSGMSYTAVGRHFGLNESSCINFIAESHNELSQNCVRSCWKKLWPEIVPTFTGFPTAEPQLRNIITMANEVGGEGFSDLTAAEVQEELLGNVGDPFTSDELEQLVELQDETDDEVSDDENKNLTLDNLGEVIRMSKALSARLYDIDPSLDRSLKAKRAIENVMLPYIELQREMRSKKAQTTITNFFSRRVPAIAEPAGILQQEAEAADTSQQQDVEAAGTSQQQDAVPAHTPQEDADLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLR7</accession>
    <name>A0A8J5MLR7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLR7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="75" mass="8015" checksum="B28CFC58D3921252" modified="2022-05-25" version="1">MAECGWPGGCGNTSLMSDFCVFQECYCKCHASPSFYLQSQATVRVAPDSPLKAKPAVLSRPPPPMGQANASATYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNJ5</accession>
    <name>A0A8J5MNJ5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">39S ribosomal protein L43-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Mrpl43-L</name>
        <name evidence="4" type="ORF">Hamer_G018734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036987">
        <property type="protein sequence ID" value="KAG7157672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNJ5"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000257">
        <property type="entry name" value="39S ribosomal protein L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7157672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="182" mass="21311" checksum="20318844C586D650" modified="2022-05-25" version="1">MTSQTWNRFWGSTFVKAPLQNGVGRYVQQLQRITFKFCKTHGGSRGMRDFIEKDLIEFARMNPGVVVYLKPRRHRSSCLKAEYLNGGEEYISAHKQSSEEIKKWVEYLRTQSGYSVERLRKYQHTDRPSIQGPWTPWMHRDQCINIAEYPQEELSCAVKREKTATQELLEKSKIFVGVNNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNK2</accession>
    <name>A0A8J5MNK2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035811">
        <property type="protein sequence ID" value="KAG7158063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNK2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="489" mass="54917" checksum="D5C857927B37D794" modified="2022-05-25" version="1">MANMSPAIHPVAEPPTVAIPTVMKYKIPKETEFDHAYEVVVALELQYKNIKFSVKPNLVGDLILPPKTTTQPRSSDNTIRPRGENNQNGPTAISSGTTCRSRHKTFKSDQGRALCYKSGQSTDKASDSGHQGDSRRGGRPRQLGDLQVASFCPRTTTMLQMSEIWTSPIQVPQKREMWHLQPKPHDRNVHSETQRRNHHDSQVPKLWKETSRLEHIMPREERADESCNGKSSTTKQNRSTSEHIRVGSSATECSQPNTHSAPTVRGFLPCTSSTRLQDKIEDTGTKSVNAGNHDKPVDSATAAPELCSSKRTEHSSIGGEHHIAWDTATPSGDHPTEYTAACQSTSGIHRRTNKTDDHYYDSEFLYDNAKTRYQLRKYNKCSYDTAHRKDAGRPDLQNSTTTSGTDDALETDIRQEEELAIQEITQNRETSSPLQQIKRNRTTNTDRQQTRDHRQERQHPEERRKKSRDSTSCASLRAGAQESATTPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPG5</accession>
    <name>A0A8J5MPG5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate sulfotransferase 5-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Chst5-L1</name>
        <name evidence="2" type="ORF">Hamer_G006292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPG5"/>
    <dbReference type="OrthoDB" id="5987729at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="1">
        <location>
            <begin position="75"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="377" mass="42057" checksum="435BE43B2E0BED72" modified="2022-05-25" version="1">MATRLHRVRAPLAFIAVIFTSSALISRRVFHVTKSGAGVEVSLQDQPHTVKKGKVGGGSSAVEGEGAAASVTQVLILSSLPRSGSTLVAELLATHHNSVLFFEPLSNPQMKPCLLNGTCVKEYISSIFKCTYERNFENWLKGKGLFLKYFHSSVSRCFGRPKEGGGACRRKLDLRSLCQNASIRIVKVIRSRLSWLEGLLNDTSLKIKIIHLVRDPRGSLTSIKNLGWNSKPSIRCSALQDDMCRYNNLLKKYPAKLTRLRLERLSMDPYGTVSDIYAFLYDGATLSKVTLQFLMEHMSATDTQPSGDNMDTQKNSLKEYQSWRWKITSELLKETEKEPACRATITQLGHVLFGSLHNARNSSIALTAHYKTAKNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQ79</accession>
    <name>A0A8J5MQ79_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Centrosomal protein of 104 kDa-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CEP104-L</name>
        <name evidence="3" type="ORF">Hamer_G026187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032460">
        <property type="protein sequence ID" value="KAG7159741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQ79"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052607">
        <property type="entry name" value="CEP104-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048739">
        <property type="entry name" value="CEP104_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 104 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371">
        <property type="entry name" value="GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21038">
        <property type="entry name" value="CEP104_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomal protein CEP104 N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="183" mass="20863" checksum="94682A3AC1169D74" modified="2022-05-25" version="1">MTTNTQFKARELKSVTVRCTGTFLKLVLHKNHVNRINLYNQIGLVALNAKSNEVEANNNSVSPDGEGGQVPGGRQQEVPLYHDLAFAMYVGTLEDQERFEYANKLRAAVTQLRTAGERLGKYEIEKRHAIDTENYERAKVKKQQAEEYREQVYKALGIEELLERKGVCLFLGTELFILCVVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQI7</accession>
    <name>A0A8J5MQI7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQI7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035275938" evidence="1">
        <location>
            <begin position="18"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="156" mass="17794" checksum="8708E1B5A87EA7A3" modified="2022-05-25" version="1">MWSLLVTLGLTFVLVEHVTIIVAGEAQMCTHGYEPKLTYLEWDTLREYLMAYEGILIPPYITGPSLPVLRCRAELAVCLEDNLHCGLVDDKPANRTLCLKNREDTTLTLNIRYQEAKVCKCMEWNSYDRVTGEVINRIPPVLHVELLNNTPCTRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQP6</accession>
    <name>A0A8J5MQP6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine--tRNA synthetase-like protein Slimp-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Slimp-L</name>
        <name evidence="4" type="ORF">Hamer_G012752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQP6"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class II (G/ P/ S/T)" evidence="3">
        <location>
            <begin position="290"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="108"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7160206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="481" mass="54910" checksum="F27ED6A3BB43C54F" modified="2022-05-25" version="1">MLKYLNFVGRLKMVNLLHRTFISYTVRRGLYFSHGMKVPVKEAPTSALYMPGNKATTMDCAVSPYLDFSKRFENLSDLKSNVNQRGLNINIHDIMNKWTTWRQLECHRLELEEERVVIAKKIKGLKNNSDQDKLRELKQHGKKIREQLKALTQELWDLEEVAVIGALQLPNHLHHSTGHCNKLLFSLFEKPAFSYQPKDHLELGEINGELEFMNNSPSAYYLKKRLAILELACSDYFTSNFKAIGYLQQSNPDFVKEVVVEGCGVQYADRDSFNKLSTSEADQDKNSQHLVGGGSLAAFSAYFTKHLIEKSEFLPQKVITAGRNYIPTNSEFPGLFGCRQSTVVDGFVVHECKPVHELEVLDEALLALIQSYNKLGLHYRVIQYSPQHLYTHESAAIGLQMFSPSTGEYHEVGRVSLCGDYISKRLWTICKTHSKSVSFLSMMHIRVCNVTRLLGLLLENKQKENGTYDIPESLQFFVNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQR8</accession>
    <name>A0A8J5MQR8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative pollen-specific leucine-rich repeat extensin-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQR8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="356" mass="39075" checksum="C4908A7E3DB4DBB8" modified="2022-05-25" version="1" fragment="single">MVMHNTLPAVRVMHNTLPAVRVMHNTLPAVMVMHNTLPAVMVMHNTLPAVMVMHNTLSAVLVMHNTLPAVIAMHNTLPAVMLWYAAHSPAVRVMHNTLPAVRVMHNILSAVMVMHNTLPTVMGDAQHTLCSYGDAQHTPVMVMHNTLAVRVMHTLLLLGDAQHTLCSYVMVMHNTPCSNGDAQHSPAVRVMHNTLPAVRVMHNILSAVMVMHNTLPTVMVMHNTLPAVMVMHNTLPAVRVMHNTLPAVRVMHNILSAVMVMHNTLPAVMVMHITLPAVMVMHNTLPAVMVMHNTLPAAMVMHNTLSAVLVMHNTLPAVIAMHNTLPAVMVMHNTLPTVMVMHNTLPAVMAMYNTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRN6</accession>
    <name>A0A8J5MRN6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tigger transposable element-derived protein 1-like 109</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TIGD1-L109</name>
        <name evidence="1" type="ORF">Hamer_G007793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7161001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRN6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="241" mass="27050" checksum="360F6D1E14D3D66E" modified="2022-05-25" version="1">MSKRPATTSLTTPQAKKSRQAITLEPKNLGAGSTAVWKWCFKCGTSVWTVGKLSTFWKSYTFKDAITNITHAWKSVPETSLNGVWHHLRHEVVHDFKGFDEGTDVKAIMKLVKEVIGDSGFQEIQEEDVTELLVSMEDPLTSEEVLEMVKKHEEEEESTDKPQTVGKELTIPKLRDFMQNVTSATQSALQHDPDMERSMQVVEALNLAASTYSSARSTDYGSAIEENHLILSVHYPHQVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRP5</accession>
    <name>A0A8J5MRP5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029887">
        <property type="protein sequence ID" value="KAG7161119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRP5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="122" mass="13917" checksum="29EAEA3183E36A53" modified="2022-05-25" version="1">MLRSVWQLQGVVGYTLGGRVGLSHYSSSSSTSSFISFFHLLLLIFLHHLLFLLRLVWISVEEVEAVRMGVWMLEAMTYFHLTTTTATSEVWSDVSSTLPTYLSPQVQSVRVVTGFCFHFYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSK7</accession>
    <name>A0A8J5MSK7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane emp24 domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Tmed2-L</name>
        <name evidence="12" type="ORF">Hamer_G024869</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027973">
        <property type="protein sequence ID" value="KAG7162248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSK7"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035194897" evidence="10">
        <location>
            <begin position="22"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="31"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7162248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="208" mass="23331" checksum="66CBC69E78B6DD1E" modified="2022-05-25" version="1">MTLRQLFTFLGIFSLLSVAESYFVTVDAHAEECFFEKVTTGTKLGLAFEVAEGGFLDIDIKIYSPDGKIVHEGERESNGRYTFPASMDGVYTYCFSNKMSTMTPKIVMFSMDVGEGIKPGHEAANGEEGEAAGGNKMEDMIRELSAALSGVKHEQDYMEVRERIHRSINDNTNSRVVLWSVFEALVLVAMTIGQVYYLKQFFEVRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MT94</accession>
    <name>A0A8J5MT94_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Chorion transcription factor Cf2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Cf2-L1</name>
        <name evidence="14" type="ORF">Hamer_G008123</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MT94"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000417">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056438">
        <property type="entry name" value="Znf-C2H2_CTCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF104">
        <property type="entry name" value="AT-RICH BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23611">
        <property type="entry name" value="zf-C2H2_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7162559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="211" mass="24222" checksum="B4EF5E1C5DED01EB" modified="2022-05-25" version="1">MKIVFTTLKGNNIVFPIIKYNEKIPRGINCAVGYNSEFITVLGISVQGYGLDTQGCSIISLETMIKSKIKPPLQMEREANCQWTDERRTTGEWQGLTPASKVHQCLHCTYNTTDSNKLKRHTLKHTGERPHSCPYCSYGTTRKELLKEHINIHTGEKPFSCPFCSYTASHRNYLKDHVRRHTGEKPYSCPFCRYRTSQKSNLNSHLLIHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUE8</accession>
    <name>A0A8J5MUE8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Secreted frizzled-related protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SFRP5-L</name>
        <name evidence="12" type="ORF">Hamer_G014487</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the secreted frizzled-related protein (sFRP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026055">
        <property type="protein sequence ID" value="KAG7164016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUE8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000001">
        <property type="entry name" value="secreted frizzled-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF148">
        <property type="entry name" value="SECRETED FRIZZLED-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035307748" evidence="10">
        <location>
            <begin position="36"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="11">
        <location>
            <begin position="47"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="62"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7164016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="213" mass="23738" checksum="06B78B5E2950036B" modified="2022-05-25" version="1">MSGSQWVRSVMPRWPALSALPLLLLLVGAAGETSAYFADWGVIGGRPQEPTCVDIPQNMPLCSGIDYNKMRLPNLLEHDTLKEAQQQAGYWVPLLNLRCHPNTQLFLCSLFTPVCLESPIYPCRSLCEAVRSGCESRMQTYSFPWPEMLNCDKFPLDNDMCITVQHTGTPGPGECDDLPLTCPAATHITLVFPLAHRGLYRIDILTLYSNCCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MV27</accession>
    <name>A0A8J5MV27_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein 235-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Znf235-L1</name>
        <name evidence="8" type="ORF">Hamer_G004811</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MV27"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7165053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="677" mass="75549" checksum="27C021AF00602F28" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MV47</accession>
    <name>A0A8J5MV47_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger CCCH-type with G patch domain-containing protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G013088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024020">
        <property type="protein sequence ID" value="KAG7165590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MV47"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF1">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7165590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="169" mass="19155" checksum="D844AAECC1246D3F" modified="2022-05-25" version="1" fragment="single">MAKEELLASIEVYQTQLEQIQGALATAGSEEKLQLQELQANLLQLLDLTLQQLNEQPEEEQIQQKEELSSQREHKEHQTEHNDTSSHEKKLDDEFALFQSEIAALSEGSDDEDSEPKHKYSKEELEAMVGTQCRSPFTEKWGGHSFHNAIILSMVTGEDGEADLHKPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVK8</accession>
    <name>A0A8J5MVK8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVK8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="111" mass="12208" checksum="FB0D8051A1BE2231" modified="2022-05-25" version="1">MVRCGETQGQITLTPQPASAITLGSRTALCELDNHFSSFITVFNERTTRLTFQGEAEQDFLRGVMGRSSSDNLANKTCLDPSWGPLNNMVGMEDGDRSRGEVIAKKKQILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVS1</accession>
    <name>A0A8J5MVS1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Galactosylceramide sulfotransferase-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Gal3st1-L1</name>
        <name evidence="10" type="ORF">Hamer_G007298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the galactose-3-O-sulfotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVS1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001733">
        <property type="term" value="F:galactosylceramide sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009729">
        <property type="entry name" value="Gal-3-0_sulfotransfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647">
        <property type="entry name" value="GALACTOSE-3-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647:SF87">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06990">
        <property type="entry name" value="Gal-3-0_sulfotr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7165456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="182" mass="21645" checksum="AD6EE506B93BC5BF" modified="2022-05-25" version="1">MVNILFRYGLSHDLRFAFPHPKVNYFGDGRIPFHADMLKATPWSNNITINIFAIHTKWNHQQVQQVMPRDTIFFTIVREPVEQFISLFTYYELQKVQMADKQFHLVMVADRMEESLVLLSHLLCWDLQHLLVLKLNGCSDSVVVYVPISSATCHYYVEDELLFIKYLRERQFMEVYHSGYHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW81</accession>
    <name>A0A8J5MW81_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neurogenin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">neurog1-L</name>
        <name evidence="10" type="ORF">Hamer_G011866</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7165951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW81"/>
    <dbReference type="OrthoDB" id="5969565at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11428">
        <property type="entry name" value="bHLH_TS_NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000006">
        <property type="entry name" value="Neurogenic differentiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF163">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX NEURAL TRANSCRIPTION FACTOR TAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="199"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7165951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="343" mass="36983" checksum="22D529B0E487A7C7" modified="2022-05-25" version="1">MSSPLRSAPATPTHSRGSITHASPSRTGGFHGPLVMVPSPSRPTLGSPATSSPTHASQRPLLSSPAPSKTPAIEHMPSHPLQHGSTKVTLNAPCSSPAKENPNIGKQSPNILQQAKTTKSGSSFSGLLQEMGMLPLKEEDMTDDSMGEEEEEDEDSMNEEEEQKKPDGGDARRRKTAGSRGGVRGRTRSPQQVARVRRNRRMKANDRERHRMHMLNNALDRLRTVLPTAPDDTKLTKIETLRFAHNYIWALSETLKGLDSHTPTHQQHLSLSVGVSGAPVNPQVPADVNMYQGGPLGPPTPYCGQGGEGDVWGAASVSVGGAFNPNSAHPQYMHYPSLPYQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWA5</accession>
    <name>A0A8J5MWA5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein 6-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Mfsd6-L5</name>
        <name evidence="8" type="ORF">Hamer_G011014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWA5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="35"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7166193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="552" mass="60992" checksum="06C095F67B37B40E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWC4</accession>
    <name>A0A8J5MWC4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022849">
        <property type="protein sequence ID" value="KAG7166086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWC4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF23">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="175" mass="19523" checksum="A4767A69FDFFA59C" modified="2022-05-25" version="1" fragment="single">SLGLQINTQKTEIFVQPIVPPIEAPQFYINGDPIKIVNQFKYLGSTLTPTCSLDMEIQTRVNLASVAFGRLRTRVFLNNDREYGTKTAVYLAKPGCPTGAISKCWKTSTLDALSVPLEYPGKIELPKTALMSPRCSCQSEKYMKMLSKLKETLAKPTRMRRISLMYVAQAVTSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWZ5</accession>
    <name>A0A8J5MWZ5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SCO-spondin-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SSPO-L2</name>
        <name evidence="2" type="ORF">Hamer_G005307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWZ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="444" mass="50190" checksum="55ED13D40A07B6C6" modified="2022-05-25" version="1" fragment="single">DTGRPLGLAVHEYSNHLNQHLTDPHHDYHDSNEYDYGEYGDEFDIYGNVDYNDFPDYVYDDYADFEDGRISSTHEWNDENNYIDGEESEMTVDDREEARGREDKHSEMKEMSDTGDERHELGSSTTATDDEDLIEGSGVDDGKYELTWSVWSGCSTSCDGGVRIRSYRCLPNQLLFEECVHAGIETQEQRACNLQPCPSTTPRTTTTTTTSEPTHPEMDKMIHTIPYMTSTDTFSPPPVTATPLDQLMTVTATTTTTTPSPPHTTTTTPITSTTARARVVEMHPLFPTTVVSAAHQPVSEPFYNNTSKMYLDDKHHKPSKMDDARLDNSVWQTDTLTDKYDQITDGVEEVVDVYGLSQALVSYCEMFYSGCERGRGNGRSRVTPNLSYRLSHLPRIPTTLEKVTMMHFNGSVTKTSRMMLKNGDKFFLICNLDNDNRLITSNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXQ8</accession>
    <name>A0A8J5MXQ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acidic mammalian chitinase-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Chia-L8</name>
        <name evidence="6" type="ORF">Hamer_G017197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXQ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000003">
        <property type="entry name" value="Class V chitinase CHIT5b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF360">
        <property type="entry name" value="CHITINASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7167287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="391" mass="44065" checksum="F07EB3F04632D921" modified="2022-05-25" version="1">MVCYYASWATYRVRDGKFEVEDIDPNICTHVVYTFAGIGTDNKIEVLDPWNDLCANWGKCGYNRFTDLKKVNPKLITQLSVGGYNEGSTSYSNMAADPAKTQIFVTSTVELLKAHGFDGLDLIWEYPTQRGGVPADRKNFITLLGKLHEALHASGMILTVAVAALKSTIDQAYDIPAMVDVVDLVNVMTYDLHGPWEKYTHHQSTLYAYKDDHGDTLYLNQNFSINYWIDGGMPSTKLTLGMPLYGRCWTLDNPDQHGYNARASHPGKAGPLTQTEGMMGYNEICDFINKDSWTVVVEEGCNEPYTYNMAYGNIWCSYEDHDSCVIKANYAREKNLAGLMVWTIDTDDFHAECSTRHFDLTRTLAETFAGNETRRISQSMLESRIDGSNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY20</accession>
    <name>A0A8J5MY20_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CCAAT/enhancer-binding protein gamma-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Cebpg-L</name>
        <name evidence="10" type="ORF">Hamer_G022903</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. C/EBP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019830">
        <property type="protein sequence ID" value="KAG7168635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY20"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14713">
        <property type="entry name" value="bZIP_CEBPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031106">
        <property type="entry name" value="C/EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334">
        <property type="entry name" value="CCAAT/ENHANCER BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334:SF69">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7168635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="157" mass="17126" checksum="841C00B7D3FC6910" modified="2022-05-25" version="1">MNSISSETGVEMAPKVEGVSSESGDDSSGGSSSGTSGSRRPVKNTEEYRKRRDRNNQAVKKSRLKTKMKTQQMIDRVTQLSTENEELEENIKILNKELGILKDLFVAHAGNAHGVQLNEAALAKMLCEEPELDEGVSLLMSFSQGSPPRTGTNESLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYA3</accession>
    <name>A0A8J5MYA3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Staphylococcal nuclease domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SND1-L</name>
        <name evidence="8" type="ORF">Hamer_G018478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7168036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYA3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00175">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd20433">
        <property type="entry name" value="Tudor_TDRD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000001">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000002">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000004">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047386">
        <property type="entry name" value="Tudor_TDRD11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="7">
        <location>
            <begin position="33"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="7">
        <location>
            <begin position="202"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="7">
        <location>
            <begin position="353"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="7">
        <location>
            <begin position="532"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="6">
        <location>
            <begin position="734"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7168036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="912" mass="101887" checksum="E009A0D086B8B0D9" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYW8</accession>
    <name>A0A8J5MYW8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G002518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYW8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="207" mass="23206" checksum="5564800B503BCE8C" modified="2022-05-25" version="1">MSASTVNQETCPICREGLDVSDVVELRQKGADGINSASVQRGDDVVVSAGEKVHITCRKRYINPKDIENKKRKKVEPPKRSARVLSSPFNSQTDCLFCGTTVTPRGASFSYVKTDTFVQTILECCDSRSDEWAFTVKGRIEYYGCDLHAADCIYHRSCSGNFRSGLSIPLQFQNVPEAKRRKSGRPKNEDQEQAFMNVCSYLENNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZ64</accession>
    <name>A0A8J5MZ64_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Upstream stimulatory factor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">USF2-L</name>
        <name evidence="8" type="ORF">Hamer_G011510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZ64"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11396">
        <property type="entry name" value="bHLHzip_USF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="13"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="65"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7168846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="128" mass="14869" checksum="DA58DD781214AE10" modified="2022-05-25" version="1">MSPRFGGSTREEKRRVTHNEVERRRRDKINTWICRLAKIIPDCPEAHSKSSQSKGGILAKACDYISELRIHNEQLTERMKETQRREMDFELLKQEVEVLKNENAALKNENALVRAQMQQQGLLGDLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZC7</accession>
    <name>A0A8J5MZC7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Low-density lipoprotein receptor-related protein 1-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Lrp1-L9</name>
        <name evidence="18" type="ORF">Hamer_G013382</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015640">
        <property type="protein sequence ID" value="KAG7169745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000007">
        <property type="entry name" value="Low density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000035">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000045">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1526"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="259"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="1002"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="1046"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1139"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1221"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1318"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1353"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1391"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1433"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1470"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="603"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="622"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="649"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="661"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="699"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="718"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="759"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="766"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="801"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="808"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="820"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1225"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1252"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1342"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1376"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1417"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1459"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1499"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7169745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1645" mass="183150" checksum="19FDC3908A05B52D" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZY8</accession>
    <name>A0A8J5MZY8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G031171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014756">
        <property type="protein sequence ID" value="KAG7170228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZY8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035253902" evidence="2">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="67" mass="7168" checksum="3EE277F0CDB1F02E" modified="2022-05-25" version="1" fragment="single">MARYLNYLAWPWLLALCFSLTVAQYGNYGGGGGGGDRQIGRPPHIDNEQGYIGGDNAPRPGSVILTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0F4</accession>
    <name>A0A8J5N0F4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative vegetative cell wall protein gp1-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013656">
        <property type="protein sequence ID" value="KAG7170753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0F4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="542" mass="60585" checksum="A454B9A5826FDB63" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0W9</accession>
    <name>A0A8J5N0W9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferric-chelate reductase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Frrs1-L</name>
        <name evidence="2" type="ORF">Hamer_G012469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0W9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF40">
        <property type="entry name" value="REELIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reelin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="124" mass="13879" checksum="FF36E85568A3FACA" modified="2022-05-25" version="1" fragment="single">RINGPPFKGFFVQARDALTNEWIGEFVKTKEVESFPECSAATHNTTPPKTKMLLTWLAPRDRTGNVIFTGTILERYDVYWSEMVAKVVPTVVSPGQSPVTFPLGQRRINPGLSPVGPLRDHRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3K7</accession>
    <name>A0A8J5N3K7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Elongation of very long chain fatty acids protein-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Elov-L7</name>
        <name evidence="21" type="ORF">Hamer_G006821</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 19">Membrane</location>
            <topology evidence="2 19">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the integrin alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF134">
        <property type="entry name" value="INTEGRIN ALPHA-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="15" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 19" id="KW-0401">Integrin</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="16 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1201"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="18">
        <location>
            <begin position="681"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1233"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1273"/>
            <end position="1283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG7172611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1308" mass="141947" checksum="A4A634509F3ACBE0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4T2</accession>
    <name>A0A8J5N4T2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative collagen alpha-1(I) chain-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010216">
        <property type="protein sequence ID" value="KAG7172885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4T2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0176">Collagen</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="379" mass="38194" checksum="00FAB7885DF0EBEA" modified="2022-05-25" version="1">MDGQEVVTEGQGVIEGQEGSQRVRRGRRGSCEIDLPFLLVDLWVVDLWVVDLWGGGPVGGGPVGGVVDLWVWSGWWTCGGGPVGGGPVGGGPVGGGPVGGGPGVGGGPVVVDLWVVDLWVVDLWVVGPVGWWTCGPVWWAWWDLWVVDLCGGPVGGGPVGGGPVVVGPVGGGPVGGGPVGGGPGWWTCGGGPVGGGPVGVDLCGGPVGGGGGPVGGVWVVDLCGGTCGWWTCGGGPVGGGPGWWTCVVDLGWWTCGWWTCGWWTCGWWTCGWWTCGVVDLWVVDLWVVDLWVVDLWGGGPVVVDLWVVACGWLGVGVVGWTCGCGLGGCGGPVGGGPVWWTCGWWTCSGGPGVVDLWVVDLCGGPVGGGVVDPGWWTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N548</accession>
    <name>A0A8J5N548_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G008503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7172990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N548"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="267" mass="29037" checksum="95E01C7D40039168" modified="2022-05-25" version="1">MSNRKVKENKDKKNEAAIDKEEEKKHLEEEEEEEEEEVGELSHYVVVCCLTVGVCCLTVAVCYLTVAVCYLTVAVCYLTVAVCYLTVAVCYLTVAVCYLTVAVCYLTVAVCYLTVAVCYLTVAVCYLTVAVCYLTVAVCCLTVAPGMDGWPDMGVGGNTGVGGNTGVRKAYTEGGDEGSSASYPWLWSGSQVGQINRLKGHTSSTTSSTPFSIITSTVFITTTITTIITIITTTTTTTTIFFTTTTVDCSRSLRMLRHMLRLCERRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5C2</accession>
    <name>A0A8J5N5C2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009070">
        <property type="protein sequence ID" value="KAG7173711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5C2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035328120" evidence="1">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="160" mass="16849" checksum="6E5A54E5E518CCAD" modified="2022-05-25" version="1">MEARMLVVVMLVGAAVHSLPHSKVNTPPLPYPQVNDPVPPQITDNRSDLNDPQVNEVALLDPAVNAVALPHHEVNAPPVPNTDANSPALPDTALIKSTRPVVPGEISVIIVKASDTAKKTGSIRSAVTTTTLDPFDEYCKEACEEGVGGPECDCPDHPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N652</accession>
    <name>A0A8J5N652_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation initiation factor IF-2-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infB-L4</name>
        <name evidence="2" type="ORF">Hamer_G018018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009070">
        <property type="protein sequence ID" value="KAG7173725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N652"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053127">
        <property type="entry name" value="Chromatin_remod_comp_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37929">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN PFC0235W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37929:SF1">
        <property type="entry name" value="SWI_SNF GLOBAL TRANSCRIPTION ACTIVATOR COMPLEX SUBUNIT SNF59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="377" mass="39512" checksum="66D8997080602BE7" modified="2022-05-25" version="1">MEMYLVWSIPGMWCYDVTCVMVSDFTTEGETKVSDITTGETEVSDIKTGETEVSDITTGRETKVSDITTVETEVSDITTGGETKVSDITTGEETEVSDITTGGETKVSDITTGGETRVSDITTGETKVNRGVRHYNRRRNKDITTGGETKVSDITTGETEVSDIKTGETEVSDITTGGETKVSDITTGGETKVSDITTGGETEVSDITTGGETKVSDITTGGETKVSDITTGGETKVSDITTGGETEVSDITTGGETKVSDITTGGETRVSDITTEGETKVADITTGGETKVADITTGGETKVSDITTGGETKVSDITTGKTEVSDITTGEETKVSDITTGETKVSDITMGRKQRGGRAYLGTKTKAFSSSKVLHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8D6</accession>
    <name>A0A8J5N8D6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glucose-dependent insulinotropic receptor-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Gpr119-L1</name>
        <name evidence="6" type="ORF">Hamer_G009787</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF9">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035273041" evidence="3">
        <location>
            <begin position="27"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1423"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="130"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="250"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="514"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="623"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="1008"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="5">
        <location>
            <begin position="1111"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1363"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="812"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1376"/>
            <end position="1386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7175776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1539" mass="168647" checksum="C8BCE08375DC84F5" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8Q7</accession>
    <name>A0A8J5N8Q7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphodiesterase</fullName>
            <ecNumber evidence="9">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PDE7A-L</name>
        <name evidence="12" type="ORF">Hamer_G020712</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.4.53"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010006619">
        <property type="protein sequence ID" value="KAG7174833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8Q7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000004">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
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    <feature type="domain" description="PDEase" evidence="11">
        <location>
            <begin position="113"/>
            <end position="435"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="438"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="558"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="672"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="934"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1027"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <end position="627"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="950"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="1062"/>
            <end position="1073"/>
        </location>
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        </location>
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            <begin position="189"/>
            <end position="193"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
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        <location>
            <position position="193"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        <location>
            <position position="229"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
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        <location>
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        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
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        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
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            <dbReference type="ARBA" id="ARBA00000621"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061458"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7174833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1142" mass="124193" checksum="C1042937C25BC801" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9D9</accession>
    <name>A0A8J5N9D9_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175224.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="138" mass="15739" checksum="CE1F08E69358EE5F" modified="2022-05-25" version="1">MTRRTETRDEINRDQLSPNEKASRRLGGRLTASPKLTSGDRVYSRTAPHPAYTRYQTPPQSPRPYQTSMGWLSHPSWAGYHIHLMKSPALFPRVHATPIIQIHKDPQMPTPQLSDGERLLTTPLLLQSVELCCTVRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9I9</accession>
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        <submittedName>
            <fullName evidence="15">LIM/homeobox protein Lhx5-like</fullName>
        </submittedName>
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        <name evidence="15" type="primary">LHX5-L</name>
        <name evidence="15" type="ORF">Hamer_G023669</name>
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        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
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                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09375">
        <property type="entry name" value="LIM2_Lhx1_Lhx5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000046">
        <property type="entry name" value="LIM/homeobox protein Lhx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049619">
        <property type="entry name" value="Lhx1/5_LIM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
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        <property type="entry name" value="DLIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="158"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="160"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="80"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7176511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="507" mass="58635" checksum="34E7BAA3C7955168" modified="2022-05-25" version="1">MSSRRFGTKCSGCLQGISPQDLVRKARDRVFHLKCFTCCVCRKQLSTGEELYVLEENKFVCKQDYMSGKLSVDPYVMSDEEEEIESMDTGDASLKSPGSDTNVLHAPNTPSTPSAPQTTDLEKVSSVNSRDEGDEDDDELENNKDDDDKRSGEEEKGSKRRGPRTTIKAKQLEVLKNAFNKTPKPTRHIREQLAKETGLPMRVIQVFSGVLRCSFRINAEQSKQKTQPFPPTTIKKIFLPILFWHCTAPHGTRVNNPSEDRLHLVANINTLPSRPPHTAINRGIPSSRATRENQTVRVLLVGVDETVSQDHDSLVWLVRQPRNPEVLGSIPPPLCTLNPDRLCLVYPSRNPEVLGSTPHDEVPERNNETQYYNSETQYYNSETQYYNSETQYYNSETQYYNSETQYYNSETQYYNSETQYYNSETQYYNSETQYYNSETQYYNSETQYYNSQTQYYNSETQYYNSETQYYNSETQYYNSERQYYNSETQHQGRGRLGVDALWTIVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NB99</accession>
    <name>A0A8J5NB99_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Smaug 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G009157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NB99"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="139" mass="14468" checksum="53E5E5A8B1C7EEE0" modified="2022-05-25" version="1">MSQRNSLPGLPSLGVGGLLSPQQFLAKRPSLQETPSELRPHITLQRTRSAPSRPHQLPLTGHARPVPAPSTSSSLAPGSNGCGELRISGASGTVLEPHFSPATSYSHLGAPPSSPDPADNDITDRLESLCISVTEHALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBL8</accession>
    <name>A0A8J5NBL8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 12-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G015339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBL8"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF306">
        <property type="entry name" value="RE01051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="519"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="44"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7176543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="564" mass="60582" checksum="065F169379C00A7F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NE41</accession>
    <name>A0A8J5NE41_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-linked-mannose beta-1-2-N-acetylglucosaminyltransferase 1-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Pomgnt1-L4</name>
        <name evidence="3" type="ORF">Hamer_G003878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NE41"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047223">
        <property type="term" value="F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039477">
        <property type="entry name" value="ILEI/PANDER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052463">
        <property type="entry name" value="O-linked_mannose_GnT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396:SF2">
        <property type="entry name" value="ILEI_PANDER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15711">
        <property type="entry name" value="ILEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ILEI/PANDER" evidence="2">
        <location>
            <begin position="109"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7178107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="273" mass="30348" checksum="88F7C0EEF4D9274D" modified="2022-05-25" version="1" fragment="single">STAGDEESGKASIAGDQEVGKDSIAGDQEAVKAPIARSEKLSAYNSEEKQNSMEAPGVHFPAGDLQNHLILDISVNMTGVELAVDGRQVYSAYNKTVPWAGITARLHAGLHLITLHQSTGQVMRATSYMTWQSNTDRQFIKDLEEIQESRLLVILGAPDFTAFMEEETIATLEDMGAHYIDRMAYMDTWCLLVYKGSGVVLEALTTSLPQHNLTKFDVSPLTVRTVVPRMQEHRCGWYTEEGMQERATFCKIYEGYGTFCICDDPPWSPHPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T2F5</accession>
    <name>A0A8J5T2F5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T2F5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="197" mass="22469" checksum="2B9C68ABEE5B4078" modified="2022-05-25" version="1">MNEDQINGLSGTDKATESNEEMLGEENQVQQETPPQIVQQPTEPTTRDLSMFLGMCDNLEEQMSLVEPNYDAREMMMCLLNKIRGHYQENYNKKVNDNKQDLITRYLSRKQEENRQVIEAIERVEVEDEGEEDRLNLASLPEDFYFEGFDLVVVAEAVVEEGGGATDIILPSPASDTSLVYIKLLNFNFKVGFLCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T6T9</accession>
    <name>A0A8J5T6T9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Platelet-activating factor acetylhydrolase IB subunit beta-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Pafah1b2-L</name>
        <name evidence="2" type="ORF">Hamer_G008529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T6T9"/>
    <dbReference type="OrthoDB" id="505607at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01820">
        <property type="entry name" value="PAF_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11852">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11852:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT BETA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="243" mass="27055" checksum="003A79C9838E772F" modified="2022-05-25" version="1">MNPAAVPTPLEDVQGDGRWLSMHNRFVNQARESEPDVVFVGDSLVASLQSTDLWEKWFAPMHSLNFGIGGDQTQHCLWRLRNGELEYIKPKAVVVLVGTNNHGHSAAEVAGGITEICQTIKEKQPESYIIVLTLLPRGEKPNPLREKNSQVNTLIKEALRQIELCQVVNIDRELVLGDGTIDHRDMYDYLHLTSQGYRRAFEPVFMLLTNLLQENDTAILNDAALASPASDNPPADNRGSCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T7V2</accession>
    <name>A0A8J5T7V2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding protein lark-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lark-L4</name>
        <name evidence="6" type="ORF">Hamer_G008543</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T7V2"/>
    <dbReference type="OrthoDB" id="79941at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="123"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="252"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="331"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7173025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="547" mass="61993" checksum="D9885D481413F8A6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJX6</accession>
    <name>A0A8J5TJX6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Red pigment-concentrating hormone-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Rpch-L</name>
        <name evidence="7" type="ORF">Hamer_G025524</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This hormone adapts the animal to light backgrounds by stimulating concentration of the pigment of its red body-chromatophores.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009397">
        <property type="protein sequence ID" value="KAG7173568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJX6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031409">
        <property type="term" value="F:pigment binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002047">
        <property type="entry name" value="Adipokinetic_hormone_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010475">
        <property type="entry name" value="AKH/RPCH_hormone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06377">
        <property type="entry name" value="Adipokin_hormo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00256">
        <property type="entry name" value="AKH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0608">Pigment</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7173568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="422" mass="45077" checksum="A1D475F112E0EA23" modified="2022-05-25" version="1" fragment="single">FPRKGQANDVLAPSHHPPHPLPHPRHPSPHPPPSPHHATSPHPPITHPHPSPHPRHPSPHPRHPSPIHVAITIRHPSSHPRHPSPHPRHPSSHPPPITSTAHHPIHRPSPHPPPITPSTPPITPSTPPSPHPRHPSPHPPPITPSTPPSPSTPPINPIHATHITPSTPPITHPPPITPSTPPITPSTPPITHPPPITPSAITHPRHPYPPSPITPSTPPIIPSTPPITHPRHHHIHVAHHPIHATHHPIHATHHTIHATHHPIHATHHPSTPPIALIYQLTPGLPSHLLSVTETIPVSVTEYDDPRPSSYPDMYVVSLTGFSLPQVRAGCALMLVVVVFASCVSAQLNFSPGWGKRAAAASGTDPAAASLHPAPPAVLTAASGANAGDSCGTIPVSAVMHIYRLIRTEAARLIQCQEEEYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLD0</accession>
    <name>A0A8J5TLD0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein RAD-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Rrad-L1</name>
        <name evidence="3" type="ORF">Hamer_G016426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLD0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF6">
        <property type="entry name" value="RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7174527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="68" mass="7644" checksum="0D4DD9CE02D39431" modified="2022-05-25" version="1">MSVENCLSTYDPHACVVVYSITDKGSFKKAEDTLTYLWRENYSKDKAVILVGNKVDLARSRIVNNSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J5Z7</accession>
    <name>A0A8J5J5Z7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tigger transposable element-derived protein 1-like 94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TIGD1-L94</name>
        <name evidence="3" type="ORF">Hamer_G010655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J5Z7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="44"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7153346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="261" mass="29935" checksum="B3D8254055C6D1C0" modified="2022-05-25" version="1">MEEGQYTNDQVFNMDESGLFWKKLPSKTFVVKSASKCRGRKLQKERITILFTTNASGTCKLKLLVIHTARKPHAYKNMDMTKLNVHWLTAFKAWMFTGLSLSWFDDCFVPDVKKFCEQHNVPFNILLLLDNAPEHSPILLDRHPSVKVLSGIPVAVDLAREAAQSATAARFSETTNDDIMEVIRDPEVIADDMLENDDVIPEQKLLYHFKVLIFKDFFSSIESFALIIIIIIIIIIIIIIIIIIIITVILLSHYYILHVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFP7</accession>
    <name>A0A8J5JFP7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MAGE-like protein 2-like 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Magel2-L11</name>
        <name evidence="2" type="ORF">Hamer_G032023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040356">
        <property type="protein sequence ID" value="KAG7155804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFP7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF5">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="255" mass="29604" checksum="AD951B5EA2C5A032" modified="2022-05-25" version="1" fragment="single">EEEEEEEEEEEEEEEEEEEEEDPDIGRNISQVFSEASGATPTYTHLHPPTPTYTHLHPLISTYTHLHPSTPTYTYLHPLTPTYIYLHPFTPIYTHLHLPTPTYTHLHLPTPITPIYTHLHLPTPTYTHLHLPTPIYTHLHPPTPTYTHLHPPTSTYTHLHPSTPTYTYLHPLTPTYIYLHPFTPICTHLHLPTPIYTHLNPLTPIYTHLHLPTSIYTDLHPPTPTYTHLHRPTLTYTDLHSPKPPPCEHNTSYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JG02</accession>
    <name>A0A8J5JG02_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CEPU-1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Cepu1-L2</name>
        <name evidence="5" type="ORF">Hamer_G024735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040609">
        <property type="protein sequence ID" value="KAG7155771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JG02"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF105">
        <property type="entry name" value="LACHESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Immunoglobulin I-set" evidence="4">
        <location>
            <begin position="92"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7155771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="189" mass="21463" checksum="EB64EE1DFEB513D2" modified="2022-05-25" version="1">MALESVHGTNLTLENVSRNQMGAYLCIASNKVPPSVSKRIIVNVNWCFGGTDWLGVWVRAPMRHPSVLSRHLLHTHPAPPRHFAPSKLQQASRKYRLEEMTDSYRVTMKLVIKNFTKGDAGQYKCISTNSLGKAETSIRLYEIVLPTQRQNSPDSDKNPHGRVMVLTQRNNFLALEKTFHALVIFPELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGK6</accession>
    <name>A0A8J5JGK6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G019247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040280">
        <property type="protein sequence ID" value="KAG7155838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGK6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7155838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="246" mass="27797" checksum="EF292B523287EC79" modified="2022-05-25" version="1">MAQVNDMEYLVRCFTFAMLKRNKMQEMEKKIVPQNTTEEMFAYIWGLDEAHSYLAPKLCFPSKSKGNATQYCRQGDMAFRKHKLCEALKYYNLAILSAPHPDSESSPRKGATSLNQVESILAQAFKSRSVVLFEIKRYEKCSDDIDLALKFGYPQTSCKKLLDMKIKCQKLISADKERVNPSAKALGPDDLYFAFEIPNPPPLAESNPTIPSLSSAVKMTFSQTMGRHVIAAKDINPGKVKKYLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGV0</accession>
    <name>A0A8J5JGV0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045104">
        <property type="protein sequence ID" value="KAG7154138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGV0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="59" mass="6540" checksum="D642DF752AC3CE33" modified="2022-05-25" version="1" fragment="single">VLPTPTHLSESFPLLHITGSPSLTPTHHSESFPYSYTSQRDLPSLLHITARPSNTPTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIG6</accession>
    <name>A0A8J5JIG6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G008840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIG6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035281762" evidence="2">
        <location>
            <begin position="22"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="342" mass="37539" checksum="21CC4ABAB964458B" modified="2022-05-25" version="1">MRRFLFASLACLALLIAGVTAEEVTDEKEDQVVEVDDLDNIDLPALLTGLFNEEETTAEDLTKFNNFIDTFHRRLNSYSRSKFDPLIIGLTKKRDKGGKSEKGKGGKGKSRKGGKSKKGGNKKKGQKKEGGGKRNERKNKKGRMGKRHPKDLDLGEAEDEDVTEDVAEDVAAVEVEEGREKREAPIAEEEEEVEEVEGVRTSRASVNGIATLRRDGDVKVVNKKNGKEIRSMFTLGPVDLKLTRKFGFGKDAITRNAKATSPSLKGRMHIFVSADGTAKVTKLHVAKPAIVTVDGSLSKETRSDRDDNNFMEKSIGKVTPVATKKLKQAIRDVLSVGSPNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIK6</accession>
    <name>A0A8J5JIK6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G009440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIK6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="73" mass="8399" checksum="44482D49B31DA001" modified="2022-05-25" version="1">MILYGAHQTHSINKYMHVSYVHMFSRKALTPTFKLECLPPTSATAKFHSYQANNGWVKKRNPLNGDGNAREEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ11</accession>
    <name>A0A8J5JJ11_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038354">
        <property type="protein sequence ID" value="KAG7156858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJ11"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="263" mass="30076" checksum="DEAB904B42974852" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPALELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDSSSDEQEATSDDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVLKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJK1</accession>
    <name>A0A8J5JJK1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G010052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJK1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="121" mass="13126" checksum="D6273537D1754F43" modified="2022-05-25" version="1">MAPFTHPFLRLHETSSKQKIWTQSRTLSGHGTKAVPVPSLVPDMLPFRGLRDSGNSCQCHLLGASLGPLRQPKPRHLCPQSGSVSYGGHAGLHVMHAATYDCVLLRDCLGRSMPDQEALAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMC9</accession>
    <name>A0A8J5JMC9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pogo transposable element-like 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Pogo-L42</name>
        <name evidence="4" type="ORF">Hamer_G008742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMC9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018586">
        <property type="entry name" value="Brinker_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09607">
        <property type="entry name" value="BrkDBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="59"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7158129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="135" mass="16019" checksum="CB02D1C9C92018FA" modified="2022-05-25" version="1">MAPIVKCRRYEACFKLKVIAYAQSHNNCAASREYGVTEKMVRDWRSKEHLLRSMPRNKCAMRRGTAHWPILEKHAVDMVHEQRQNGYIVSRNMIRIGALKWAKQNQEHNKDFKATASWCSRFMERSNLVLRQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMJ7</accession>
    <name>A0A8J5JMJ7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ZSWIM3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMJ7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048325">
        <property type="entry name" value="ZSWIM3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21599">
        <property type="entry name" value="ZSWIM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZSWIM3 N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="89" mass="10371" checksum="A42E729446A17EC4" modified="2022-05-25" version="1">MEKGQQNYYATVQRRMSNPNFIPDIKYHDELWYSCVHGSKKHNKKSTAQCPNTSTFKVDCPYQVKLQSSDDGQCLVITKHINEHNHEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMV9</accession>
    <name>A0A8J5JMV9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ETSous factor-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Ehf-L4</name>
        <name evidence="4" type="ORF">Hamer_G016236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMV9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="3">
        <location>
            <begin position="250"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7161187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="524" mass="58462" checksum="2980122C46B8A657" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMX8</accession>
    <name>A0A8J5JMX8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Activated CDC42 kinase 1-like 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Activated CDC42 kinase 1-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Tnk2-L2</name>
        <name evidence="6" type="synonym">Tnk2-L3</name>
        <name evidence="5" type="ORF">Hamer_G026761</name>
        <name evidence="6" type="ORF">Hamer_G026921</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034926">
        <property type="protein sequence ID" value="KAG7158485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010023750">
        <property type="protein sequence ID" value="KAG7165754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMX8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="73"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7158485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7165754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="250" mass="27297" checksum="2808753C688453C6" modified="2022-05-25" version="1">MDKNHIVDNKGQEAQVSLVRVTTILRKTSTPTSSSIPHTSSSSHTSSSSHTSSSSTTSSSGGRDLPQLTWDHLSLMGKVGTGRYGVSHHGQLTLDNGDVTEVVVKILHSGKDNTKEARVLHELAGTGGAPILYGVTTDPHAIVMQYCRGVTLSTILHHFRYQVHHRQEAYDATCVALAEFHGAGYSHLDLHAGNVIIDTSTSPYTCHLIDVGMSERIPPDDDWYEQTDWVALQDIQTRLHLHSPDDLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JN67</accession>
    <name>A0A8J5JN67_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G030726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033225">
        <property type="protein sequence ID" value="KAG7159378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JN67"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="147" mass="15143" checksum="39C2308BAE7B5CCF" modified="2022-05-25" version="1">MVVVEERVDTGYGDVKLCNVLFEGRIGVVSGSDGGRASGYSATEMGAKGGASGVGYVPRGKSKEGDDQVLCIYLGGYEERKRHVDDGAGNNRGGCSLPRDSVFVAVVPVTGAEKKASCERIAVVPLTGVYGAEKMVSSECIGVCDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNA7</accession>
    <name>A0A8J5JNA7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNA7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="539" mass="58087" checksum="84C807CC876E156E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPG3</accession>
    <name>A0A8J5JPG3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G014125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPG3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="106" mass="11659" checksum="A15ACA83852ABB9B" modified="2022-05-25" version="1">MDAINLTHSKVQNFLHVLFAAVKQAQQAPLVVNSPDTRRRVRTVQKRSPDSHLFYFLLPKSLTQSSASSKKRLWAKPAISIIDAAEEEAVSGVGQGRSTVTNTTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPY9</accession>
    <name>A0A8J5JPY9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Harbi1-L9</name>
        <name evidence="15" type="ORF">Hamer_G010825</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPY9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF286">
        <property type="entry name" value="NUCLEASE HARBI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="14">
        <location>
            <begin position="119"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7162162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="334" mass="38012" checksum="6877F7F00279931F" modified="2022-05-25" version="1">MLRREIRMRRLSKELFCELLNMIQGDLERSDNRGRPLPAVYQLLIALHFYCSGSYQKVVGDQHGLQVSQPTVCRTIHRVSEALAKRYSQFVTFPSVAESADVHAKFYEVAQFPNVIGAIDCIHMRISNPGGAMAEQCKNSKGWYSVNCQVVVGPDLKILTAIVRWGGSVPDWQIYENSRLKQVLEQGEYGHLVGDSAYQCQRYLLTPVINPMTQAEKCYNRSHSSTRRKVKRVFGMVKRRFQCTSQELRSNPKTSCAIILSCFALHNFALERQGPPDDSEALYAPDDGPQDRFTGDDDPEGESYRQHIIYEWFSHEPSGVPHQPDDGMCETQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ49</accession>
    <name>A0A8J5JQ49_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Slc6A5-L4</name>
        <name evidence="12" type="ORF">Hamer_G021726</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031508">
        <property type="protein sequence ID" value="KAG7160256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQ49"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF265">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 10" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7160256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="622" mass="69907" checksum="1D803E84A6675C7B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSC7</accession>
    <name>A0A8J5JSC7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DM4/DM12 family-like protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G008952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSC7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398">
        <property type="entry name" value="AGAP007094-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398:SF6">
        <property type="entry name" value="AGAP007094-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="602" mass="66607" checksum="9DB3851F2988A89D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSG0</accession>
    <name>A0A8J5JSG0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COMPASS-like H3K4 histone methylase component WDR5A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">WDR5A-L</name>
        <name evidence="2" type="ORF">Hamer_G007762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSG0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822">
        <property type="entry name" value="CARBOHYDRATE BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822:SF2">
        <property type="entry name" value="F-BOX AND WD-40 DOMAIN PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="408" mass="42604" checksum="1FE185AFA50EE565" modified="2022-05-25" version="1">MNILVVKTGWDQNKQWSKKIVVSVVVITVNSSLVESYQKGVFLVTYSMSSGHLNMSQRPSSGVSEVGSGRGSSPPNLVLPQLPSQACSSSSTRTSPSRTSVHGTSPHGKRRISTSSSVASGTSLASLLVKLHQPASSSLSLEGKLKIRTTIWLHGGCRSQVRSGQVLHSGGGTILHATDSDGRLVTWRGRSVGVVQAEGGVDVRAAVVGGLDNQVVTFTRGQVTVRDANTLGPVATMDQGVGGHLLSRGSLWAVSGRGRELVGGGGGLTWWDARTGSVTRSISGVPVRGPALAWHPHSNRVVSGSWGGGADSVKVWEASTGRLTHLLHSDAVNTSVYSTVWAGKEVVAVGGADPNLLRLTTLDNTTVGVLRGVRNTVWALDALLGRGHQGTRLALASASTLYILDVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSW8</accession>
    <name>A0A8J5JSW8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ETSous factor-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Ehf-L2</name>
        <name evidence="6" type="ORF">Hamer_G016234</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSW8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF190">
        <property type="entry name" value="ETS-DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="624"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="374"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="441"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7161185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="721" mass="79137" checksum="5A15CDDAF2D8FFB3" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTI2</accession>
    <name>A0A8J5JTI2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamate-gated chloride channel-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GluCa-L1</name>
        <name evidence="11" type="ORF">Hamer_G020801</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026066">
        <property type="protein sequence ID" value="KAG7163887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTI2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
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    </dbReference>
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        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="713"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="742"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="779"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="10">
        <location>
            <begin position="24"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="244"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7163887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="962" mass="108843" checksum="56889B1CC49F35A6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTR9</accession>
    <name>A0A8J5JTR9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G030985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Malacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025596">
        <property type="protein sequence ID" value="KAG7164101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="72" mass="8337" checksum="15328789DD25216A" modified="2022-05-25" version="1" fragment="single">MEVLRYLSTAADPNMKETFIYQLNQLHLNPFPYPFLESGVGSLFLGSTLLPEHYNSGFMARHFCIWDKELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTZ8</accession>
    <name>A0A8J5JTZ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Proteasome subunit alpha type-2-like 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Psma2-L13</name>
        <name evidence="2" type="ORF">Hamer_G007951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTZ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035325144" evidence="1">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="121" mass="13354" checksum="018FB01F2C8A612D" modified="2022-05-25" version="1" fragment="single">MMSFSLQMLLAVFTLLTPVVTIAPTTDMVGKMVFWNLEQHFPGCHLVLITTQHSRVSSSIIRHMGVGVAAGVVVEAGWVLSQDQLTQDHLLQGLWEDTRTTCRALILDLTTSNNTNLVLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JU52</accession>
    <name>A0A8J5JU52_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JU52"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="96" mass="10822" checksum="E08110B0668C0FCB" modified="2022-05-25" version="1">MAPKKVFGIRKDETTRKNFAMPAACAPFYRLEFLSQEKATNQLSRLVEKSVHETESSSSSEGDDKDHDVEDELFQALYETPPGMKETVTFSSVSWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVD7</accession>
    <name>A0A8J5JVD7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026750">
        <property type="protein sequence ID" value="KAG7162888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVD7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="103" mass="10710" checksum="92DE50901C5285EA" modified="2022-05-25" version="1" fragment="single">MGAKGGASGVGYVPRGKSKEGDDQVLCIYLGGYEERKRHVDDGAGNNRGGCSIPRDSVFVAVVPVTGAEKKASCERIAVVPLTGVYGAEKMVSSECIGVCDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVP6</accession>
    <name>A0A8J5JVP6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Hamer_G002259</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="410"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="478"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="726"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="889"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="513"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1015"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1098"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1015"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7163181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1336" mass="148425" checksum="F4D0278EDEE2317A" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVS8</accession>
    <name>A0A8J5JVS8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial intermediate peptidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MIPEP-L</name>
        <name evidence="12" type="ORF">Hamer_G002234</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVS8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="11">
        <location>
            <begin position="192"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="11">
        <location>
            <begin position="369"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7163158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="570" mass="64674" checksum="A1A8D09B2E4EF18A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW95</accession>
    <name>A0A8J5JW95_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate receptor ionotropic, delta-1-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Grid1-L3</name>
        <name evidence="16" type="ORF">Hamer_G002720</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW95"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035193217" evidence="14">
        <location>
            <begin position="26"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="785"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="271"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7163526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="814" mass="90156" checksum="5C62369B518B8262" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWC2</accession>
    <name>A0A8J5JWC2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chorion peroxidase-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Pxt-L5</name>
        <name evidence="5" type="ORF">Hamer_G018316</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027102">
        <property type="protein sequence ID" value="KAG7162790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWC2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF4">
        <property type="entry name" value="CHORION PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7162790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="124" mass="14065" checksum="9EE8BC160ECDCD05" modified="2022-05-25" version="1">MQKLYKSVDDIDFFVAGITERPVSGGLLGWTFLCVVGDQFARLKKGDRFFYDLGGQPGSFKEPQLQQIRESSWARVLCDNSNMQAVQPLAFRQTNSRFNEPVPCQSPSIPRPDWSFWRGESAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWL7</accession>
    <name>A0A8J5JWL7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial tRNA-specific 2-thiouridylase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TRMU-L</name>
        <name evidence="3" type="ORF">Hamer_G013152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024020">
        <property type="protein sequence ID" value="KAG7165645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWL7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7165645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="135" mass="15210" checksum="0086CDE36E021B63" modified="2022-05-25" version="1">MFTEPIYWIHSPASQLFTKGQLECQFRFQNTASLVPCVITTHTHNPWHHSPTQNNMVVSLATPLRAITPGQYAVFYIGDECIGSARIIRPGPSLYALNVGECRTRILKERLRQPPPSGKERIPGKRAPKQEATKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JX19</accession>
    <name>A0A8J5JX19_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CLCN3-L2</name>
        <name evidence="11" type="ORF">Hamer_G001990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7162959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JX19"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="538"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7162959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="649" mass="72029" checksum="9D43E3909477711F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JX79</accession>
    <name>A0A8J5JX79_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">March6-L1</name>
        <name evidence="12" type="ORF">Hamer_G011137</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JX79"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase MARCHF6-like C-terminal" evidence="11">
        <location>
            <begin position="44"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7166307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="182" mass="20321" checksum="18670E0EA502F3FA" modified="2022-05-25" version="1">MEFMRLQKHNVMKGYIWQGTKALIALVVVAVVVPLMVGVLMELDWALGVLYTKIMCALVMMGPNWWLKTNLEHIYLGGVRGLDLNLLVGQTALPVIACLGACLTVPYVTAHTIAPLVAPPTSLVMITLLSSLIIMQVVQFTRLYEHIKNDKYLVGRRLVNYDHTSSQPPPPLQENEVTPFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXL8</accession>
    <name>A0A8J5JXL8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative elevenin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXL8"/>
    <dbReference type="OrthoDB" id="6367086at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035168568" evidence="1">
        <location>
            <begin position="30"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="127" mass="14136" checksum="DFB274ABB924ECF9" modified="2022-05-25" version="1">MAASAFLSVRLTTVVLLTTLACLQAYTNAVDCRKFVFAPVCRGIIAKRMVSEKRSSFRPTADTQWNSQYRAPTETEAENLLLASSYDDVMEPRPQEDMVVVRAGSDVVQVPAYVFGVIERSLQGERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYE7</accession>
    <name>A0A8J5JYE7_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Hamer_G002850</name>
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    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Multicrustacea</taxon>
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            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1088"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1138"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1227"/>
            <end position="1340"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="1600"/>
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            <begin position="36"/>
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        </location>
    </feature>
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    </feature>
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    </feature>
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            <begin position="1576"/>
            <end position="1590"/>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAG7163630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1760" mass="191291" checksum="27E6DE0C6E6F57F8" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZA4</accession>
    <name>A0A8J5JZA4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative CUB domain-containing protein-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Cdcp-L1</name>
        <name evidence="5" type="ORF">Hamer_G004966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZA4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255">
        <property type="entry name" value="COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255:SF31">
        <property type="entry name" value="CUBILIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7164583.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
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    </evidence>
    <sequence length="325" mass="35468" checksum="7837A15303166DFA" modified="2022-05-25" version="1">MTMVLSSRRCEYDWVTVGEGGGSTPPERMCGDWSARLKLLRYVSHSNRVVITFVTDYAHHFPGFRARVSARTDWYNWHLSLPPLLPPLPSTSPFHLSLLLLSPVSPSRLPPSHIRAQDVCVTPLVKLLVAGPSCRLTQVIIYANVVWSSSRKCYGVGAEWEEWGYEDYGTGTLYWVGGTLHPDSHTWSWRDGSPLNVSGMAYTHATPTPLLSYTHVHSMPTPTSYTHNLRTPTSTTPASTLVFGGDKWSLGAGVKWCVLHTEVGGVEGRYLAGDGVSLCLSLQESTCRHRGPASTVTHRSHSPPTSVTSSAATSAPGGYPVSPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5JZS2_HOMAM</name>
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        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G013079</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024020">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
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        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="305"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7165581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="516" mass="56011" checksum="B4488CB512CD57BF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZX1</accession>
    <name>A0A8J5JZX1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 664-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Znf664-L2</name>
        <name evidence="14" type="ORF">Hamer_G013043</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056438">
        <property type="entry name" value="Znf-C2H2_CTCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23611">
        <property type="entry name" value="zf-C2H2_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1096"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1125"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1156"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1185"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1213"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1241"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="569"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="784"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="879"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="962"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="574"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="988"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7167567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1432" mass="155376" checksum="70D341FDBE471511" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0E5</accession>
    <name>A0A8J5K0E5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH2 domain-containing adapter protein B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Shb-L</name>
        <name evidence="5" type="ORF">Hamer_G005070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0E5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051846">
        <property type="entry name" value="SH2_domain_adapters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127">
        <property type="entry name" value="HEAVYWEIGHT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127:SF32">
        <property type="entry name" value="HEAVYWEIGHT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="639"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="523"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="572"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="527"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7164680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="677" mass="74136" checksum="E0D45A0AC9BC7466" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0Y5</accession>
    <name>A0A8J5K0Y5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein 12B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Rbm12B-L</name>
        <name evidence="3" type="ORF">Hamer_G017272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0Y5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035171508" evidence="2">
        <location>
            <begin position="21"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7164875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="434" mass="46824" checksum="C9374270B11C403D" modified="2022-05-25" version="1">MSGMKLMVVVVVVMTGWTWAKVMVYKSMRQLGTGACGDDLGNFLAASDTVCALTCKQNNLCQGFSFQDNLASGTHSGGHCYLHQLLSSPNGQSHATCYVPEHFLMNVSTTATTDPLTVTPNVLSLTNAVPATLQPTTTTTKDPPTTITTTTVPPTTTTTVPPTTTTTVPPTTTTTDPPPTTTTDPPTTTTTVPPTTTTTVLHHHHQFLRPPQFLQPPPPQFLQPPPPQFLQPPPPQFLQPPPPQFLQHQTKSFFLGQTTSSASPEPTSLANTQLVSIEDGQLCNNNWGAVGICRYEDTAGNVYHYLICKTPPNNLHFNTDKTSPQCTTNDVMECMTIDCGPDNIIKGFTTTDSYLGPCTTDYSTTEGDVLNPNDCHTVAGPLQNLSPSQASWTDWRICGGTDDDFYVVTKVVVTKVGNVWEMTSIKCCRIVNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1Q9</accession>
    <name>A0A8J5K1Q9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fand-L</name>
        <name evidence="14" type="ORF">Hamer_G004661</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7164938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1Q9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000038">
        <property type="entry name" value="Putative pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="13">
        <location>
            <begin position="13"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="11">
        <location>
            <begin position="154"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="12">
        <location>
            <begin position="359"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7164938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="708" mass="84156" checksum="0F45B910E9A3A2AC" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K229</accession>
    <name>A0A8J5K229_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022879">
        <property type="protein sequence ID" value="KAG7166079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K229"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="217" mass="25486" checksum="5E9DB32F94E2DE2E" modified="2022-05-25" version="1" fragment="single">QIYFISLWDQFHRDLYAEATETNVEKFIGTADTADKLQENDKFADKQDFAEKFAEKFSQKFVDKFTEKKLEDMDEDKFADNTNKKYWNWRMLFQQPTLLFFIKCFSKQQQQKQQNKCEDSWTFWMGYLMGYLFNSVLMSVIITIIIIARSVIKRRSITVNSIKQDSLPDNDTLTSSETPPPSYFELKIDDQNYCDYNSSSITSTLTTPPSSYPLAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K325</accession>
    <name>A0A8J5K325_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Pseudouridylate synthase 7-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Pus7-L2</name>
        <name evidence="2" type="ORF">Hamer_G013288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015640">
        <property type="protein sequence ID" value="KAG7169667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K325"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="414" mass="48217" checksum="10F943391E798E36" modified="2022-05-25" version="1">MFTSKHRARMEDEGSVDYSTEVMENGKERKANDSEDDGDGVVCLDSDNADTKDVEFAEEVINLDDKESGEDKSSKKGDKKDGEGEKDGMREKEAKEMKKKKYSDFQVNEIDSDGEMIRITNQNIPDEPEEIPDMPEVMPLELTDVKIRELERMLGLGKQKKEEESKENDKVEEEVEEVIQEKEEKKEEKKEKVKKESKEEKKEKDSKEEKKEKESKEEKKEKESKEEMKEKESKEDKKEKVCKEEKKEKESKEEKKEKVSKEEKKEKVSKEEKGEKKEKEEKKEKESNEEKKGKEVMEESTNETEDEETAKKDDENLPALTEIWINVDLTDEAGIDLINQAIKAQYRGVEISYGETSDGGKYIVVRKRKAGAVRRDKVGWPKDQLYTTFVLYKENVETVEAINQIAWKARYGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K399</accession>
    <name>A0A8J5K399_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G013632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022272">
        <property type="protein sequence ID" value="KAG7166619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K399"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="7679" checksum="FFE83396CB09CC78" modified="2022-05-25" version="1">MTVDHLTPSCLSGSNETNPALPHKGGVGRPSYPLYIDPISHWLLQTRLSKIENTAFSITSQSADQFALVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4P5</accession>
    <name>A0A8J5K4P5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G013608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022272">
        <property type="protein sequence ID" value="KAG7166603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4P5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="273" mass="30381" checksum="16357891E4681EB1" modified="2022-05-25" version="1">MGPSCSTVREASELGTRNSPNHAHDSHSCPHWTLSSRIASDASNSRLPPPTASDTSHWKCHEPGVNVWHGCTRRLTATPASPPPSPYVSLHTTTDNTLSSLVETQQTVITSVTTLTEKLDAFISRLEGTIGLLPPHVAQHKATPVPPPLPHLALVRVLIHPYPLLRPRRPQPPLLTPIWTSPLSRLVTILPSLRSTVLPTSRTCLTFSLVNFTHNFHSYYVSRPHIKRRFEYYAWTLDERILQAEKKMVEDGVSFQGDRPLTVSTSTSHPEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5D5</accession>
    <name>A0A8J5K5D5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 536-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Znf536-L6</name>
        <name evidence="14" type="ORF">Hamer_G012811</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5D5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051967">
        <property type="entry name" value="Krueppel_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45925">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7167365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="153" mass="16994" checksum="0724B077BE604FF7" modified="2022-05-25" version="1">MKVVDLSSHSFQTTDASGDLHRQDSWHRLGHSTSVTPFLLAARGSMGIGLLEGQTSTSNNGINEGGQPRRRRSVLSEADLSTALNCPACGKVFAGTKRRYHLERHLITHTGERPFPCPHCPYRANVRENLARHIRHRHPNTVVPTEETRALDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5E8</accession>
    <name>A0A8J5K5E8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S15a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RpS15Aa-L</name>
        <name evidence="5" type="ORF">Hamer_G018368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7167943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5E8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7167943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="87" mass="9724" checksum="5D35F06E2DA7B3A5" modified="2022-05-25" version="1">MGYIGEFEIVDDHRAGKIVVNLTGRLIKCGVISPRFDVQISAIEKWTTNLLPSRQFGYVVLTTSGGIMDHEEAKRKHLGGKILGFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6J4</accession>
    <name>A0A8J5K6J4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7167980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6J4"/>
    <dbReference type="OrthoDB" id="2104607at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043721">
        <property type="entry name" value="DUF5662"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18907">
        <property type="entry name" value="DUF5662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="666" mass="78723" checksum="6FD5A43E5608B025" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8H6</accession>
    <name>A0A8J5K8H6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019798">
        <property type="protein sequence ID" value="KAG7168640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8H6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="107" mass="11884" checksum="34B548842E1208F8" modified="2022-05-25" version="1">MFRPVQEKEDSLTIVLTEDIQEHDITVTIVLLQPETSSHQNIQESSSSRTSVAERCSSSKTRKPLAATTEQRCRSHTPSAIADDNQTRSTVTGDPTHELGSLNTKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8I0</accession>
    <name>A0A8J5K8I0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SET domain-containing protein SmydA-8-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SmydA8-L10</name>
        <name evidence="7" type="ORF">Hamer_G022004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017059">
        <property type="protein sequence ID" value="KAG7169379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8I0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053010">
        <property type="entry name" value="SET_SmydA-8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455:SF5">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="52"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7169379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="531" mass="59687" checksum="3E5862EC9854EA42" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K942</accession>
    <name>A0A8J5K942_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021896">
        <property type="protein sequence ID" value="KAG7166929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K942"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="263" mass="30058" checksum="1366418A0C3D50C9" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDALFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDSSSDEQEATSDDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K9R0</accession>
    <name>A0A8J5K9R0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K9R0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="107" mass="11896" checksum="6D695AB7DB39F95E" modified="2022-05-25" version="1" fragment="single">MRDGTFTVTASAPCLALPVPHLRPTDHNPTQVYTALHYQSSFFETTEDSKSTACDKVLHSKIGESFTFFLVTISACIFVVCLLTFCYIISANSFQLIRSSVLQQQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KCA0</accession>
    <name>A0A8J5KCA0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor SOX-14-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Sox14-L6</name>
        <name evidence="7" type="ORF">Hamer_G020195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014868">
        <property type="protein sequence ID" value="KAG7170193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KCA0"/>
    <dbReference type="SMR" id="A0A8J5KCA0"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22029">
        <property type="entry name" value="HMG-box_SoxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF323">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="46"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="46"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7170193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="398" mass="44737" checksum="B26FFC64345B39C6" modified="2022-05-25" version="1">MLPHANYERVPVPSSSTVFGSMLVNDSSNTPYSDATQTKKHPPNHIKRPMNAFMVWSQMERREIIKFAPDMHNAEISKQLGRRWKLLSEEQRRPYRDEAERLKQLHMREYPNYKYRPRKKGQKAQLKGVSEKSVGKITKAKDHCNNKDRAKNVVNVISNTRITHTQGLEVDHNKLGIKITIDDDFKRSHRMPQNGVMALTPHSPPEVPASPPCDLPDSPESASMYEDPPAFTYNPSVTAQYHTPTSTHGLTALSHHTTTSTHNTVSSPNTRIKQEPDDLYEIVYTPQSLASPGLGSPVCETPHIKTEIKTEIQSPRNNTSGQITEHATLDDLYNITDFIPISDIKMDLDSLDADIDFDAVSTSSGSHFDFPSVTEETDHLLSDCGLSHTWIGSSSFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KCA6</accession>
    <name>A0A8J5KCA6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative trithorax group protein osa-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">osa-L2</name>
        <name evidence="2" type="ORF">Hamer_G016079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014436">
        <property type="protein sequence ID" value="KAG7170276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KCA6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="486" mass="53436" checksum="3C59DD8AC4CB0DD0" modified="2022-05-25" version="1" fragment="single">QRCLCVMFQLEVVNSVKREEMQETTPLEENNSHIEHNTSAPQAEDTTIDNAPVNIEDQVGQSQEVNQNNPEKTKITLQVEPLNQSPSLQTTNGEVPPAALYLPDPSITYISPPASITASQRSHKLRYYLKYDSFLALYYQMADSSTVQNAAMYMLSYPPPYSSPGFVQVYSPVPPPTDGSGTPTDFTPPLPTTTMPARPEGWDPNVQGNDSEAMKMNQGMPPYMWTYSVPIMPSPGVDDNKQTPVPGEGGFQQVVAIGAWGPGYMGDYGPHQPVPGPPHYNYPPLLREPAHHPYPPPPYHDSRDGNREGPPFPHHYHHHRGRGRGGPHHYSHHPRGSHHNNHQYSNNYQGNNFQDPSTMGIPTGEMGRGGGGQRSLPPRFQRGGGASSGRGLLRPFHNSGPPYQSNNMPHHQRNHQYEGQPLMHMGSRNGNVGSGGLASPPLLTFVESDRPHGVMPLPPQDTPPLPPQDHMPMAVPPGYYPAPPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KD09</accession>
    <name>A0A8J5KD09_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Ionotropic receptor 21a-like 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Ir21a-L11</name>
        <name evidence="18" type="ORF">Hamer_G010216</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KD09"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035307728" evidence="15">
        <location>
            <begin position="25"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="17">
        <location>
            <begin position="297"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="16">
        <location>
            <begin position="423"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7167814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="715" mass="80414" checksum="6E1ECC113AFE9386" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KFG5</accession>
    <name>A0A8J5KFG5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">28S ribosomal protein S35-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Mrps35-L1</name>
        <name evidence="2" type="ORF">Hamer_G002653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KFG5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="1">
        <location>
            <begin position="81"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="256" mass="29339" checksum="A4967ECE447D3574" modified="2022-05-25" version="1">MTVKVGSGHLLHFTFFFLLILTTLLLDKFGQLFLSQLFPSMTQELLLHLFLLNVLEPLTSHLTGKLNNVLHILIDCGEARKVSLKSLDLDDHGRDKLLRLVKDRYDAATDCLTIVADRCPLSQQNYDYCQYLLTVLYNESMVSTGYENLNYSLIPDYPPLLTLLWVPCQVSLSNNTVVKTEPWEHEKEVADRERYLWEGSPSQARFQTIISAKEDCTPEEVIKDYEQVVTDLHNEGEDEPTLSRYRESVLKVVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KFR6</accession>
    <name>A0A8J5KFR6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Tba3a-L4</name>
        <name evidence="16" type="ORF">Hamer_G013782</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012455">
        <property type="protein sequence ID" value="KAG7171318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KFR6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="48"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="247"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7171318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="450" mass="49964" checksum="445332FF836DD466" modified="2022-05-25" version="1" fragment="single">RECISIHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKAIGSSDDSFSTFFSETGSGKHVPRAVFVDLEPTVIDEIRTGVYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDIVLDRIRKLADNCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQVATAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPSYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPVISAEKAYHEQLSVSEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVSRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFTEAREDLAALEKDYEEVGVDSADAEGEEEGEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KLQ5</accession>
    <name>A0A8J5KLQ5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G012381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KLQ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035322303" description="MARVEL domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11627" checksum="25D3C6B4F6DECD7D" modified="2022-05-25" version="1">MVAAMLITPLLFVFYVTGSRSHQQTIWLIFSPSQELAINFLFFSFLFISASVSMSFWHQPTYWKDYKAAGISMGVFLYISSAAYLVDTVLASKNYCCQPKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KR90</accession>
    <name>A0A8J5KR90_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Involucrin-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">IVL-L4</name>
        <name evidence="2" type="ORF">Hamer_G028419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012227">
        <property type="protein sequence ID" value="KAG7171399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KR90"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="476" mass="52501" checksum="C178CEDD2D2C45B3" modified="2022-05-25" version="1">MNDTPMAVVSDSDTSQEVVTESDAPQEVVTDSDTPMEVITDSDTPLEVVTEEDTPLEVVTDNDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPSEVITDEDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPLDVVTEEDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDSPLEVVTEEDTPLEVITEEDTPLEVVTEEGTPLEVVTEEDTPLEVVTEEDTPLEVVIEEGTPLEVVIEEDTPLEVVIEEGTPLEVVTEEDTPLEVVIEEGTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPLEEVTEEDTPLEVVTEEDTPLEVVAEVTLEMATRGILPKKCPVELLPKCSGPIGLFTRPRIPWSQEPKVISNQRLSTQLTRSLKPVKLLPNRPGPWPRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJQ5</accession>
    <name>A0A8J5MJQ5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ethanolamine-phosphate phospho-lyase-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Etnppl-L4</name>
        <name evidence="3" type="ORF">Hamer_G023184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045868">
        <property type="protein sequence ID" value="KAG7153964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJQ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7153964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="176" mass="19936" checksum="B380FB33C46F35DE" modified="2022-05-25" version="1">MSEKQRLTKQETIELRKKHIGPSCKLFFKSDPLKIVRASGSYMYDENGHRYLDCINNVCHVGHCHPYVVSAGMQQMAVLNTNSRFLHDNLVLYAKRLTSLFPKQLSMCYFVNSGSEANDLALRLATIPVIAYHGHVSSLINISPYKFNLPGGEGQKDWVHVVSVYLLLILHLCSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJU3</accession>
    <name>A0A8J5MJU3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation initiation factor IF-2-like 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infB-L17</name>
        <name evidence="2" type="ORF">Hamer_G030351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045424">
        <property type="protein sequence ID" value="KAG7154084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35001">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35001:SF5">
        <property type="entry name" value="PROTEIN CBG01852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1324" mass="135875" checksum="E3A5560B69266FF2" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKL9</accession>
    <name>A0A8J5MKL9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosylmethionine decarboxylase proenzyme-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SamDC-L</name>
        <name evidence="7" type="ORF">Hamer_G015046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-adenosyl-L-methionine + H(+) = S-adenosyl 3-(methylsulfanyl)propylamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKL9"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7154685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="268" mass="30671" checksum="BC7EB5F7507C6A80" modified="2022-05-25" version="1" fragment="single">QPGQSLASTEQATSDPDLYYSRKNFKRPELQVSPHRTFEEEASILDQFFPGGRAYCMGSVNRADCWYLYTVSPGRPRYRPNAARHNLPHNRIGKIHREPDQTLEVLMMDLDPEKMKWFYKNICPTAAEATKKSGIDRLIPEMMIDDYQFEPCGYSMNGLMRSVPSSRKGYGGYMTIHITPEPEFSYVSFETNVPQKSYKDLIARVVATFGPKQFVLTFFTSVESGASIGIEDDSCSVPQYSDYDVDDIQICRLQGYDLTYALYNRFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLI8</accession>
    <name>A0A8J5MLI8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA-directed DNA polymerase from mobile element jockey-like 58</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G012093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLI8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="138" mass="15500" checksum="1236C1C3798D9408" modified="2022-05-25" version="1">MTIVTSVSRVIGNMVQQIPMNSIEVGLSVGLRQTRRKIHLSCSWISPPSSNDRDTGMGHRLSQILRGTTDQMFQTTEDVCSRCASPGHQHSDCKIKIKKYAVCGGPHSSDQECLKWRKECRVAKLRNVKQLSYKEALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPU9</accession>
    <name>A0A8J5MPU9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CD209 antigen-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Cd209-L2</name>
        <name evidence="4" type="ORF">Hamer_G016662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPU9"/>
    <dbReference type="OrthoDB" id="406096at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039689">
        <property type="entry name" value="CD72"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15028:SF6">
        <property type="entry name" value="B-CELL DIFFERENTIATION ANTIGEN CD72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15028">
        <property type="entry name" value="CD72-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035287537" evidence="2">
        <location>
            <begin position="22"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="561"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="478"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7159260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="718" mass="78843" checksum="915F32AFADD32AA7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQB9</accession>
    <name>A0A8J5MQB9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Capzb-L</name>
        <name evidence="8" type="ORF">Hamer_G022428</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032177">
        <property type="protein sequence ID" value="KAG7159814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQB9"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051490">
        <property type="term" value="P:negative regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010591">
        <property type="term" value="P:regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0117">Actin capping</keyword>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7159814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="279" mass="31489" checksum="7D8DCFFF368ACE8E" modified="2022-05-25" version="1">MMEQQLDCALDLMRRLPPQQIERNLSDLIDLVPSLCEELLSSVDQPLKIARDKNSGKDYLLCDYNRDGDSYRSPWSNTYDPPLEDGAMPSDRLRKLELDANQAFDQYRDMYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVVEKSSGRSAHYKLTSTAMLWLQTNKQGSGTMNLGGSLTRQMEQDCPVSESSPHIANIGRMVEDMENKIRNTLNEIYFGKTKDIVNGLRSVQPLPDRKQEAALRNEIAKALIRRQAKGSNDENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQK1</accession>
    <name>A0A8J5MQK1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Gamma-aminobutyric acid receptor subunit gamma-3-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Gabrg3-L1</name>
        <name evidence="17" type="ORF">Hamer_G012674</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQK1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="740"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="771"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="804"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="855"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="16">
        <location>
            <begin position="27"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="15">
        <location>
            <begin position="259"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7160133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="880" mass="100770" checksum="736E47D0A725879A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUE7</accession>
    <name>A0A8J5MUE7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ domain-containing protein 6-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Btbd6-L5</name>
        <name evidence="2" type="ORF">Hamer_G005229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUE7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF4">
        <property type="entry name" value="AXUNDEAD, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="410" mass="46108" checksum="3DA9B923CDC862CB" modified="2022-05-25" version="1">MAMNSPVFEAMLYGPMAEKDTLSLDDDQPEAFKCLLDFIYTDNINFTEVKLTLQVYRLAHKYQLDKICQICSENLAEEITEENFPFVYDTALFFDDHKLLQRCEEVLITAADQVLKSKNITFLRSSSLKQLLSHPRLAVSSEANVFSALLSWGLSQVKAEYAVGPVTYLPVVKKESPKSISAKEDENEKEEEAIEKHQYKEEMLIPKLRQVVEEFLPLVRFLTMTAEEFIQHVIPSGIVAVEEGVNILQGIEGMYSTLPKFVSSLAAKKRYPSLITSLVLSISPMNNGTSINFKYYTKINHYLLQNFQTTKAVLVVKISSAFISSLNEGVVTVNDSNGEIGKGTWRGTACHFKRPIKLVPGVIYNFELNIEAASIAVRNNNINVSQGNDVTFVGTTSCLHNLEIEYITEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVA6</accession>
    <name>A0A8J5MVA6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023748">
        <property type="protein sequence ID" value="KAG7165755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVA6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="184" mass="21032" checksum="024D31447E09E923" modified="2022-05-25" version="1" fragment="single">MWSAVLVLCSMWSTELSWCYWKYVVYRVGATVAVVYRVGATVVCGSQSWCYCSMWLKVLVLLAGKHCSMWLIELGAYCMWSTELSHCMYIGELLVCGLQSWCYCGMWSYSELELLAELLLYVAHRAVVLLLYVVYRAGATVVCGLMMSYCIWWSTKLSYCSMWSTELVLLQYVIYKDGATVVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVS7</accession>
    <name>A0A8J5MVS7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024242">
        <property type="protein sequence ID" value="KAG7165501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVS7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="331" mass="37063" checksum="105C5146B5DC48EB" modified="2022-05-25" version="1">MATQGDIVTMEPNVQAIMVVQLSLGEIRDHLPPNRVHTELKKGKQPTNTAVFIGWLISTGSYKVVDGTPQLKVMLREVNPTEEMGSALEVMFHEDLALGVDEHLKKIQEDQWLMIWGYRQESSLYVGMEGSVRIFYVPSHTSPLPYRNIITIWECRLEMKKRMLYGVVREVVKHPQITKIGSHHTLLSLVDPTCLHPGADQDDIILHIFINDPGKGSARVQGSARVQDSARVQDTVRVQDSGRVQDTARVQDTARVQDTARVQGGRDHPTKRTNPSPSGETIDDESLNFLVMMIEEVPTIILKELNQALRDTFLSRLQVCDATVASALDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW89</accession>
    <name>A0A8J5MW89_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7165966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW89"/>
    <dbReference type="OrthoDB" id="6352875at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="265" mass="29701" checksum="78C46BB14A6F78D6" modified="2022-05-25" version="1">MTEVPADGPTWTGVLSAYHVNQQLHAHCQVFGSRPPAVFTFFLNDHRITDEDGWVMKHKPSRNTRDMIWNSSSTLSIHLNSESIKTLFPKSLPQYHSYILQETRRNMSSGNPKSNIHYRLQWQEPYSSHDAAPYSNNPFTPPYTHTHSERRSAHESLYSLSSISPIASSYSRPSSVARDLYSSLPSKNQKINLTCVANIGGLSLKTSTWTLLSFPTELHFSSKSRLSENSGPTLAPSPCLQAITVLCLTVNAGFKGFLLNLARYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWI7</accession>
    <name>A0A8J5MWI7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Cits-L2</name>
        <name evidence="7" type="ORF">Hamer_G011775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7165877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWI7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7165877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="174" mass="19660" checksum="14EA50B7E958FD4F" modified="2022-05-25" version="1">MKTITIKRPNQEVLLWVTKLRAEIGDDVTEDQLKEFIWKTLKSVQVVPGYGHADLRKTDPRYSCQREFALKHLPDDKLFKLVAKLYNVVPPILTELGKVQNPWPNVDAHSDVMLQYYGMTEMNYYTVLFGVSRALGVLSSLVWDRALGLPIERPKSMSTEGLQKLVGATAAQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXU1</accession>
    <name>A0A8J5MXU1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vacuolar protein sorting-associated protein 37B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">VPS37B-L</name>
        <name evidence="10" type="ORF">Hamer_G005271</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7166969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXU1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF27">
        <property type="entry name" value="LD45836P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="9">
        <location>
            <begin position="73"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7166969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="197" mass="21926" checksum="2D60AA835D30D742" modified="2022-05-25" version="1">MMSAEPDYGAALRIIKHLPTEELRDLMKNIASEQEMLLAANKSLAEFNLSLEPKLSQAKQNLITKYEAAAQLTEEVNTMKGEMDSTSGQYTADTLQALLQTAAHEIEEETENLVLSFLDKEQDVDEFLSEFLSKRKTAHLRRIKAEKIEDILNKQSSAHSAPYPAQPPASGGAGYGPNQWSSPYPTQPMNMPMPGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXU5</accession>
    <name>A0A8J5MXU5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CD2-associated protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Cd2ap-L</name>
        <name evidence="6" type="ORF">Hamer_G013049</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXU5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11874">
        <property type="entry name" value="SH3_CD2AP-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11875">
        <property type="entry name" value="SH3_CD2AP-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF92">
        <property type="entry name" value="CIN85 AND CD2AP RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035159785" evidence="4">
        <location>
            <begin position="20"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="111"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="349"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="586"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7167571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="698" mass="77354" checksum="EDC7788A709E7817" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYN5</accession>
    <name>A0A8J5MYN5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein timeless-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Hamer_G018435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the timeless family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7168004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009649">
        <property type="term" value="P:entrainment of circadian clock"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007725">
        <property type="entry name" value="TIMELESS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26019">
        <property type="entry name" value="HTH_TIMELESS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05029">
        <property type="entry name" value="TIMELESS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="10">
        <location>
            <begin position="1386"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="949"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1128"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1347"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="975"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1139"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1173"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1243"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1259"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1274"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1298"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1317"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="1541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7168004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1659" mass="190258" checksum="C5AC4DBAE3B66530" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZQ4</accession>
    <name>A0A8J5MZQ4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SEC13 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Sec13-L</name>
        <name evidence="15" type="ORF">Hamer_G012376</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZQ4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7170135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="311" mass="34270" checksum="2140807CE0509C4E" modified="2022-05-25" version="1" fragment="single">VSVISNVETGHDDMIHDAQMDYFGTRLATCSSDRSIKIFEVKGSSQTLIADLREHEGPVWQVAWAHPMYGNILASCSYDRKVIIWQEDGHKWKKIHEYANHDSSVNSVCWAPHEHGLILACASADGSVSIMTSTAHTWESKKITNAHSIGCNAVSWAPAVASGSADGSNRSGSAVQRIVTGGCDTYVKIWRFDSTNGEWTEESKLEGHSDWVRDVAWAPSIGLPRSIIASCSQDRRVIIWMNDGVTGVWQPRELNTFDDVIWHVSWSVTGNILAVSGGDNKVSLWKESLEGQWVCLSDSAKGQPASEQRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0C6</accession>
    <name>A0A8J5N0C6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variable charge X-linked protein 3B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">VCX3B-L</name>
        <name evidence="3" type="ORF">Hamer_G013446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0C6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="484" mass="56150" checksum="50F1FBED2AFB005F" modified="2022-05-25" version="1">MLQQCCCDPYKRTYITAIFTAVEAVAFGVLNLVLICMNNCIIPPPEDRPPIGFDKFWAWYFYDGEKCPSVGNFTYEPPDWINQLFPLGNRRHETSVEANYSYQITYLSLHSAWFITCLILFYDAAARAEVRQEQQHMQMVQQEQWQQNSQPGVDNRAFAGVQAAPVILQPPLLPRRPPAPKEQRPFTYLNSNFQPDNPHDLEGMRANPASVPEPVVNALRNSKMIRNDPVFPAAPVQNFYIPDDGYAHKRDRSPEVPSKPFHRRHDSLQNFRTQEPEPGFVRSSSIRDPSRMPQYNDSPHYDKHPGYQKPWDEKSRPSNMSNLKKFPRVNLIEGKEEARLQPQGQRRRLSPPSSHQRGDEEPYPLPASQKRNHSLPMDRERPYSSQGNREMPYSRQGKREKPYSPQGNREKPYSPQGNREKPYSPQGNREKPYSPQGNREKPYSPQGNREKPYSPQGNREKPYSPQGNRERPYSADAKPFTYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0T7</accession>
    <name>A0A8J5N0T7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Paternally-expressed 3 protein-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Peg3-L3</name>
        <name evidence="3" type="ORF">Hamer_G013930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012946">
        <property type="protein sequence ID" value="KAG7171125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0T7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="2">
        <location>
            <begin position="722"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7171125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="885" mass="101667" checksum="7EA4760D9B451CB6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1Q0</accession>
    <name>A0A8J5N1Q0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pre-mRNA 3' end processing protein WDR33-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Wdr33-L2</name>
        <name evidence="7" type="ORF">Hamer_G014729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1Q0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000237">
        <property type="entry name" value="Flowering time control protein FY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="87"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="472"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="582"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7171592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="675" mass="73307" checksum="9A559AAA52DA5724" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3I5</accession>
    <name>A0A8J5N3I5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vigilin-like 37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">vgl-L37</name>
        <name evidence="4" type="ORF">Hamer_G029583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010973">
        <property type="protein sequence ID" value="KAG7172480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3I5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="193"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="272"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="361"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="440"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7172480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="515" mass="57385" checksum="8AC2C9BCF8220B89" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3U6</accession>
    <name>A0A8J5N3U6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="4">PARP</shortName>
            <ecNumber evidence="4">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Parp12-L1</name>
        <name evidence="7" type="ORF">Hamer_G006917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3U6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WWE" evidence="5">
        <location>
            <begin position="139"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="6">
        <location>
            <begin position="169"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7172692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="381" mass="44798" checksum="084FCA1F9CF40163" modified="2022-05-25" version="1" fragment="single">SDFNDSLVFQYLKNTHKHFKKSKRGQHDCICMFNMMKRCTRDPCTQVHSTMPYLWEINYNENFLRLSYEQSDHLERLFCHPAQDKAEFPPLPSNVRHHSRYEQLRNVLSSSESWQVDMETMKISSGSSSIVIRRLSTPSDITYDLRVASRWIWYWCDDNGSWKPYTHGDNNKYFVVALSDHLEYHMHFSNEFHFFVKVGGQHYDIDTREMTQKNIITGKIRKIRRRPACTVLEDKETSFDRMFTKLPKDKNNDLSKVNEQYLFHGTKHSVIDLICSENLDWRLFGRNVGNAYGQGTYFANNAKLSDSYSKTDDSGLRAMFIVYVLVGTMTVGNRSMEFPPTNTTTGRCFDSTCNDRHDSTIIVKYNKDEYYPAYLVKYRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N478</accession>
    <name>A0A8J5N478_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative P21-Rho-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Hamer_G008615</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
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            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CDC42SE/SPEC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="CRIB_dom_sf"/>
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        <property type="entry name" value="SPEC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502:SF9">
        <property type="entry name" value="CRIB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="12">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="12">
        <location>
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            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="12">
        <location>
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        </location>
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    <feature type="domain" description="CRIB" evidence="12">
        <location>
            <begin position="564"/>
            <end position="577"/>
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    <feature type="domain" description="CRIB" evidence="12">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="12">
        <location>
            <begin position="720"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <end position="378"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
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    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="579"/>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
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        <location>
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            <begin position="257"/>
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        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="523"/>
            <end position="541"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
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            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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            <dbReference type="EMBL" id="KAG7173092.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="790" mass="89745" checksum="386D4BB8541B7362" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5N5U5_HOMAM</name>
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        <name evidence="8" type="primary">pros-L3</name>
        <name evidence="8" type="ORF">Hamer_G022346</name>
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    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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        </lineage>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
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                <person name="Greenwood S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.500">
        <property type="entry name" value="Homeo-prospero domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023082">
        <property type="entry name" value="Homeo_prospero_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037131">
        <property type="entry name" value="Homeo_prospero_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039350">
        <property type="entry name" value="Prospero_homeodomain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12198:SF0">
        <property type="entry name" value="HOMEOBOX PROTEIN PROSPERO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12198">
        <property type="entry name" value="HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05044">
        <property type="entry name" value="HPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51818">
        <property type="entry name" value="HOMEO_PROSPERO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Prospero" evidence="7">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7174026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="102" mass="12242" checksum="FD8F4F3E951DF6E9" modified="2022-05-25" version="1">MEKYARQYLSEGVKNGDDIAVNMDAEIIRALNLHYNRNNHLEQIPEHFRYVVEQTMKEFFKAIQEQKDTEQSWKKAIYKVIARLDETVPEYFKSPTFLEQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N873</accession>
    <name>A0A8J5N873_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Ribophorin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RPN2-L</name>
        <name evidence="17" type="ORF">Hamer_G020687</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with DDI2. Interacts with TMEM35A/NACHO.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the SWP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004953">
        <property type="protein sequence ID" value="KAG7175641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N873"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055375">
        <property type="entry name" value="Ribophorin_II_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055374">
        <property type="entry name" value="Ribophorin_II_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055373">
        <property type="entry name" value="Ribophorin_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05817">
        <property type="entry name" value="Ribophorin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23861">
        <property type="entry name" value="Ribophorin_II_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23860">
        <property type="entry name" value="Ribophorin_II_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035342119" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2" evidence="12">
        <location>
            <begin position="18"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II N-terminal" evidence="13">
        <location>
            <begin position="24"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II second" evidence="15">
        <location>
            <begin position="277"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II third" evidence="14">
        <location>
            <begin position="369"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="16">
        <location>
            <begin position="506"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7175641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="606" mass="65191" checksum="03BAD5F37BE09609" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9R9</accession>
    <name>A0A8J5N9R9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003754">
        <property type="protein sequence ID" value="KAG7176200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9R9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="231" mass="23769" checksum="E70953185AB61DC2" modified="2022-05-25" version="1" fragment="single">MKRTERHLASLPASLTSPASTSGSDTPLTPAAASTPPIFSSFTPSTSQSPPTTSPPPSPSTSHCFSRTPSPLPSLPPSPIVVNTSPSPERPLTSESPERSIPPSPPDKYGAPQTHHEKATVTTPQLPGSLPSLTHRETPLATKSHSIIKSSSHTSSGPSSSSSSSSSSSSSASSTASSGSSSSVITHTHSYQKFSLDNLLKSTQDHTLSPSPTILSAKHIKTGSKSEENGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9W7</accession>
    <name>A0A8J5N9W7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G029777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005895">
        <property type="protein sequence ID" value="KAG7175489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9W7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="480" mass="53099" checksum="746FBA9745DD38DB" modified="2022-05-25" version="1">MFSVAAYNHVLPPQYQQCGVLQPRVTSTIPAVWRFTTTCSSTIPAVWLQPRVTSTIPVVWRPTTTCYLHNTSSVAAYNHCGGLQPRVTSTIPVVWRPTTTCYLHNTSSVAYNHVPPHTSSVRPTTTCYLHNTSSVAAYNHVLPPQSPVVGGLQPRQWRPTTTCYLHNTSSVAAYNRVTSTIPAVWPTTVLPPQYQQCGVLQPRVHPQYQQCGVYNHVLPHNTSSVAAYNHVLPPQYQCGGLQPRVTSTIPAVWRPTTTCYLHNTSSVAAYNPCYLHNTSSVAAYNQCYLQIPVVWRPTTTCYLHNTSSVAAYNPCYLHNTSSVAAYNHVVAAYNRVTSTTSSVAFYNHVLPPQYQQCGVYNHVYLLNTSSVAAYNVLPPQYQQCGGLQPRVTSNTSSVAAYNHVLPPQYQQCGGLATCYLHNTSSVAAYNRVTSTIPAVWRPTTTCYLPQYQQCGVLQPVFLHNTSSVAAYNHVLPPQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA05</accession>
    <name>A0A8J5NA05_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ras GTPase-activating protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RASA1-L</name>
        <name evidence="12" type="ORF">Hamer_G015495</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA05"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11788">
        <property type="entry name" value="SH3_RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035652">
        <property type="entry name" value="RasGAP_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF146">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="70"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="167"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="239"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="371"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="410"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="11">
        <location>
            <begin position="580"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7176676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="953" mass="108457" checksum="EFA2E940476D995A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAC5</accession>
    <name>A0A8J5NAC5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G026294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004709">
        <property type="protein sequence ID" value="KAG7175703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAC5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="287" mass="32434" checksum="ED6F07353F13617D" modified="2022-05-25" version="1">MVLGCGRSGSACGGSVWFVWFVWFVWFVCRGCGRSGRFVGARVKAGVWMRDRKMWLERAVVKALVSGTLRRWADVIGEGLDTGVLGGALKDSRRMVEGLSCSRRWRMVEIGFAVGVGVLGVVTKFVLGLPGRCIIITWGRVSSSGLQGSGEKSRRNLEPSKQCVFARNKANKVLGYKTSEVILKLYLCSYKTAGHPKIYLLQDKVILKLYLVLTRGHPKLYLVLVRPHLLYAVQFWSPYYRMDIESGRTRRTRLIPLKHLNLQSSRDESTKLSNQERTRNNGFKLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAL9</accession>
    <name>A0A8J5NAL9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-reactive protein 1.4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Crp4-L</name>
        <name evidence="6" type="ORF">Hamer_G020967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004117">
        <property type="protein sequence ID" value="KAG7176122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAL9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051360">
        <property type="entry name" value="Neuronal_Pentraxin_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277:SF125">
        <property type="entry name" value="B6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277">
        <property type="entry name" value="PENTRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035261385" evidence="5">
        <location>
            <begin position="17"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7176122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="246" mass="27154" checksum="1AD11112A3B8662B" modified="2022-05-25" version="1">MAGWCWCLLMVLGVTGEVFGSSTVDSTCASTSYFKTEAVQYVEYVAEMPDLSGFTLHYWIHLLEPSSFVCPFAYINEADDTSIQVLVVRSELSWTWVIQVNGVVVSLVTSPVSLVGKWHHVLHSWHSHSGNWSFYLDGHLVDSGINLETKGMTVSGGGRAYSGQRYNAITSSEPCDEGVHGWLTLLGLDTRGIQRAEHWMSRLMVTVLVDGCSPEQGGDILTWDYTPRQGYGGVMTTRANTTCGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBI1</accession>
    <name>A0A8J5NBI1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA repair protein complementing XP-A cells-less</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Xpa-L</name>
        <name evidence="12" type="ORF">Hamer_G015423</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBI1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21076">
        <property type="entry name" value="DBD_XPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000001">
        <property type="entry name" value="DNA repair protein complementing XP-A cells"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022652">
        <property type="entry name" value="Znf_XPA_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01286">
        <property type="entry name" value="XPA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="11">
        <location>
            <begin position="213"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7176617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="352" mass="40997" checksum="8DD869781E609EFF" modified="2022-05-25" version="1">MSSKTQQKRSIFDDSDELSVPMKKSKFEAQKKNGSDSSKNCGIRKTHKTTGRKTKSTNDKSPTESPQECEPSKTPEKDQDDSVVVAKKDKLVLSPAQRARMEQNRQQALLIRQDKINRRNPYVKNEEKKDTTKVLQINNTKLIDTGAGFFIEENGELSNDDILAGIKLVYEPGPLLEIDRPHCLECEKPFDNSFLLQNFDHPTCDKCKESDDKHALIPKTDARNEYLLKDVDIEKREPPLKYILRKNPHNSRWGDMKLYLKLQVEKRALEVWGSEEAIESAMKKKEDQSELRKQKRFNKKMKELRMNVRSSLYTRATKNHEHEYDEEVYLPDEDEYSRTCKTCGHSYTFDKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NC94</accession>
    <name>A0A8J5NC94_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cuticle protein 6-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Cu6-L8</name>
        <name evidence="5" type="ORF">Hamer_G015378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NC94"/>
    <dbReference type="OrthoDB" id="6377716at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF196">
        <property type="entry name" value="CUTICULAR PROTEIN 72EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035243888" evidence="4">
        <location>
            <begin position="17"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7176578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="356" mass="38408" checksum="B1F2E950F880A0EF" modified="2022-05-25" version="1">MNALVVISACICAAAGRPQYYPYTAGYIADPYAAVAPYVASPIQYTLDYNVVPDAAQVPEAYAGQYVVAPPAIPTEYKSQHHSQDEFGQYAFGHVSHDQAHSAVRDYTGAVRGSYTYIDTNGEEVVAHYTADQNGFRVSSNALPVAPVFDGEAPVALQFELEAPVFNLEQVAETPEVMEARAEHFRLVEEHKAAVAAALAAATAEEATEAPEEETAEAAVEEETAEAPVEEETAEAPVEEETAEAPVEEETAEAPVEEETAEASVEEETAEAEAPEETTETPVEEEVAAAESRRKRQVLIGNHFVFPEFYKSLPIEPVVVEPKTVVEGAVGTAALRDAELLRIINTPNHAVSYRVL</sequence>
</entry>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </source>
    </evidence>
    <sequence length="158" mass="16795" checksum="D1C2C9A3E2EAE051" modified="2022-05-25" version="1">MFWVEQRTYTLSLRGGWLPMVGDGGEVRMGTGSSITRINGHTMALPTPIPNAWGHATHATQVIADHEVTGHGEGHESGQMGGHGSGEGHGSGEGHRSDGRSQGELAVPGGGKSRRRYRSRSLSQSSTDSYSTCEYWLPVCVVNPPSTSPVPLHYACTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T2C7</accession>
    <name>A0A8J5T2C7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T2C7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="243" mass="28231" checksum="55C164F77C1C9A6C" modified="2022-05-25" version="1">MLDALAFLPLEDVIEGMKYLKTVIPSETEELLMYFDRTYVSGSFRLIQQPVAMPSDALMPMRMRHTSSMFAPHLWNVHDATMNNNARTNDICAGWNNKFFNLVGHYHPSIWLVIEWFQLEEATVSTIIKQDAVGNPPQGRVRQRYGLFNDHVKPNSAKGSPIPVHCILAHSWYLAHLWLLLFKKSCFRDLFTEKENGNKMVVVQEEEDEEEEEEMVVVQEEEEEKEEEEAGRRRGQVAVYSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T3K3</accession>
    <name>A0A8J5T3K3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myotubularin-related protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MTMR3-L</name>
        <name evidence="6" type="ORF">Hamer_G020320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011048">
        <property type="protein sequence ID" value="KAG7172440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T3K3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF75">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="165"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="531"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="616"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="799"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="859"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="619"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="363"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="425"/>
            <end position="431"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7172440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="933" mass="103628" checksum="2FAA97109AA391E7" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T948</accession>
    <name>A0A8J5T948_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YLP motif-containing protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Ylpm1-L2</name>
        <name evidence="1" type="ORF">Hamer_G020145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009549">
        <property type="protein sequence ID" value="KAG7173521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T948"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032204">
        <property type="term" value="P:regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026314">
        <property type="entry name" value="YLP_motif_con_p1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13413">
        <property type="entry name" value="YLP MOTIF CONTAINING PROTEIN NUCLEAR PROTEIN ZAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13413:SF0">
        <property type="entry name" value="YLP MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="82" mass="9466" checksum="CD5F7222505E7515" modified="2022-05-25" version="1">MSCGKPKSIEDWLQLSDDYDTKVAQPGKKRVRWADVEEGKKQTAARERGFVLGQTDWRRMTDLSYGSSALVQIRYIEGRENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJ21</accession>
    <name>A0A8J5TJ21_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Cytochrome oxidase c assembly-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Hamer_G009172</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJ21"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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            <begin position="23"/>
            <end position="43"/>
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            <end position="87"/>
        </location>
    </feature>
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            <begin position="65"/>
            <end position="75"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7176369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="87" mass="10268" checksum="4C8B7083A7065746" modified="2022-05-25" version="1">MDMEIQLDVVMRKLPRASRVADFLHKSFVVTCVGMTLFSMFIIGERTYSYFYVIKPRRLEEERRKLAEEESKSFETEIPDIAETLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5TKW9_HOMAM</name>
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    </protein>
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        <name evidence="3" type="ORF">Hamer_G008403</name>
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        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
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        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF5">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="1575"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="906"/>
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            <end position="996"/>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF05057"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1795" mass="197810" checksum="624565C49ED05621" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5TVX2_HOMAM</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
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    </reference>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="81"/>
        </location>
    </feature>
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            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7165902.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7177932.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7178082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="81" mass="9169" checksum="D8FAAB2339A72078" modified="2022-05-25" version="1">MSKALSARLYDIDPSLDRSLKAKRAIENVMLPYIELQREMRSKKAQTTITNFFSRRVPVIAEPADTSQQQQDVEAAGTSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J5S0</accession>
    <name>A0A8J5J5S0_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">Hamer_G009500</name>
    </gene>
    <organism evidence="2 3">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Kohn A.B."/>
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                <person name="Timp W."/>
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                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAG7153807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="86" mass="9516" checksum="0F2D9D4F6D54F82D" modified="2022-05-25" version="1">MVLSRGHRCPRRHNTGPPSCLVHPDSHLSGVPQAHSLHTTVTTLVMCLSVPSRRYVINSRNSSSTDFRQERNSPPVPHHATLPFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J718</accession>
    <name>A0A8J5J718_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046433">
        <property type="protein sequence ID" value="KAG7153586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J718"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033375">
        <property type="entry name" value="Cggbp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007021">
        <property type="entry name" value="DUF659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32344">
        <property type="entry name" value="U1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32344:SF1">
        <property type="entry name" value="U1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04937">
        <property type="entry name" value="DUF659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF659" evidence="1">
        <location>
            <begin position="86"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="318" mass="36124" checksum="6EC52AFB2E8D657F" modified="2022-05-25" version="1" fragment="single">VVVSSSKKFQVQQHIQTAKHAMKKEAKTSAKQQALLPTTLSRPGPKHSQFNQDLCRALVAADIPMNKLNNKELVSFLEKYTDQKVPSESTLRKNYVPDLYNETLDRLREKVGDNSIWVSLDETTDVDARFVANFVFGILGPEEERDKSYLLNLKVLDKVNHSTMAAFFTDSLGLLWVDGIKYDRVLLVCTDAAPYMVKCMAGLEILFPKMIHVTCLAHCLHRFAELARAVMPDVNVLISTVKKVFLKAPSRKERFRQIAVVTRWGTWIKAALYYADNFETVKCVVESFDPTASVHMKEAQNVLKKDGLREDLIFIRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J753</accession>
    <name>A0A8J5J753_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G019814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047210">
        <property type="protein sequence ID" value="KAG7153251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J753"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="42" mass="4755" checksum="3D202103302DA727" modified="2022-05-25" version="1">MCSVKALAKETSNQHMSNISEQHMSNIWFKDCLLDDIDKEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J8N2</accession>
    <name>A0A8J5J8N2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ester hydrolase C11orf54-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Hamer_G014938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J8N2"/>
    <dbReference type="OrthoDB" id="5119241at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17298">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015021">
        <property type="entry name" value="C11orf54_DUF1907"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204:SF1">
        <property type="entry name" value="ESTER HYDROLASE C11ORF54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204">
        <property type="entry name" value="PTD012 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08925">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01168">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUF1907" evidence="7">
        <location>
            <begin position="21"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7154592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="309" mass="34076" checksum="FA70C5FD2D86E777" modified="2022-05-25" version="1">MSLTVEQRPLHVPPLEEVAVVLQDALCMNFDEVVVSVVECPDLRNKPYCLKGRGLCGSPRLGDVGGVPNLIPEVKMDKVYDIKKLAVSVDLPNAFIVGAGAGPHNFVGVNSELMANVKMGENPSNGSLISKIDAAGNYKLMDLPDSETRCALMLNMFASEGQAGKVLKIWAKKRTGDTNFVTCLRQALENHFREKPVGLGGTFRLVKGHAKCHVMPDFPSAPLTCDEDVNKWLCFFDMPAPMVFLSTLISKDPGLDLRVEHSHGYGDDCGGHYHYDTTPDTVEYEAFYNVAEFIYRVDRPKVTHDFGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JB37</accession>
    <name>A0A8J5JB37_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 46 member 3-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Slc46A3-L3</name>
        <name evidence="7" type="ORF">Hamer_G019860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041650">
        <property type="protein sequence ID" value="KAG7155442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JB37"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7155442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="551" mass="61361" checksum="69698CEB263A127A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JBW0</accession>
    <name>A0A8J5JBW0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metallothionein-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G022472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallothionein superfamily. Type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042381">
        <property type="protein sequence ID" value="KAG7155250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JBW0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002045">
        <property type="entry name" value="Metalthion_crustacean"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017854">
        <property type="entry name" value="Metalthion_dom_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00858">
        <property type="entry name" value="MTCRUSTACEAN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57868">
        <property type="entry name" value="Metallothionein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0480">Metal-thiolate cluster</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
            <note>in cluster B</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
            <note>in cluster B</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
            <note>in cluster B</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
            <note>in cluster B</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>5</label>
            <note>in cluster A</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
            <note>in cluster B</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
            <note>in cluster B</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>6</label>
            <note>in cluster A</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
            <note>in cluster B</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
            <note>in cluster B</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
            <note>in cluster B</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
            <note>in cluster B</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
            <note>in cluster B</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
            <note>in cluster B</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
            <note>in cluster B</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
            <note>in cluster B</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602045-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7155250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="72" mass="7984" checksum="3C5D78C5070F6723" modified="2022-05-25" version="1">MLPPYRMIRKNENYKFFLFVSDKCECAEGGCKTGCKCTSCRCAPCEKCTSGCKCPSKDECAKTCSKPCKCCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JC04</accession>
    <name>A0A8J5JC04_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lachesin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Lac-L</name>
        <name evidence="2" type="ORF">Hamer_G024736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040609">
        <property type="protein sequence ID" value="KAG7155772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JC04"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="143" mass="15098" checksum="B2E03AEB37A154A1" modified="2022-05-25" version="1">MYLSTTEHHYNVYPTTPNSKSVNSLDLLGRDGGQNRQLEGVAGRGSGGVGSAEGATGGLGVEFDKEQSRQRQRQRLEYGEGRTDNGEGYLGGGFGAQGEGHENQSGGSSVSTQPRGCWVTFRVPVLVSLGVLVVREGGAVWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCI7</accession>
    <name>A0A8J5JCI7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Disintegrin and metalloproteinase domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Adam1-L</name>
        <name evidence="3" type="ORF">Hamer_G027082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042758">
        <property type="protein sequence ID" value="KAG7155176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCI7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7155176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="161" mass="17578" checksum="CA004AD916EF0774" modified="2022-05-25" version="1">MRLDSGPPSVCEFQGSVRGVPGSWVALSLCQGIRGKELTVEPALDASTLEDPHHIFSASSHVPGACGVRSVVKKNKSKNNNSSSNSDQEDAVLQRERREALHGDPMWTSKTTRFVELVLVADNSFYKNFLDKSVQRCRGIVNIVNAVSCDTVHPSRPFIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCZ8</accession>
    <name>A0A8J5JCZ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 1A-like 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Arpc1a-L23</name>
        <name evidence="6" type="ORF">Hamer_G030226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046865">
        <property type="protein sequence ID" value="KAG7153520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCZ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7153520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="79" mass="8790" checksum="AD289310315F02B2" modified="2022-05-25" version="1" fragment="single">MTEVFRFGLVPIACRARNEDRSQVALSLNNNEVNIYGRAASEWKLQETLQGHDLRVTGIDWAPSTNRIVTCGAVSLLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JE27</accession>
    <name>A0A8J5JE27_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G006649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JE27"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035290377" evidence="2">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="161" mass="17674" checksum="64571E5F1608C7CE" modified="2022-05-25" version="1">MTGKTVTMGWFLLQLALTSKVVMSHEPDAPPATPDQAVNLLVGHNLDQIRQMMNVNGEEEDTGDDDLPKIRSSPWVEVTEEHTVGDLPPEAIHPLGGIDPKDLTAIFRASLHEGDDGVGVGEDEDMDAVEEGSNRNKRAATSTFMHPAALYKSFFRDQDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JF25</accession>
    <name>A0A8J5JF25_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041885">
        <property type="protein sequence ID" value="KAG7155366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JF25"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="45" mass="5127" checksum="57F61A5A80F87AF4" modified="2022-05-25" version="1">MYPGDGGRGGRDEEREEEGYGVGRWLERERGRDRSLKGGWGLSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGN4</accession>
    <name>A0A8J5JGN4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glutamate receptor-like 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Glrk-L16</name>
        <name evidence="13" type="ORF">Hamer_G006134</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGN4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF38">
        <property type="entry name" value="IONOTROPIC RECEPTOR 100A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="12">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7156389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="134" mass="15202" checksum="022A360850C59A7B" modified="2022-05-25" version="1">MATTRPLIRIAAEEWVPYTNLQADENDSLSIGGPMGNFLHVFSIMMDFDYELVRPPDGLWSARFPNGSYKGMVGMLMREEVEFALGPFFATDERESVVDLTVPFYNDFYAIFMIRPTLSNDVLGFVKPFMPLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIF3</accession>
    <name>A0A8J5JIF3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039216">
        <property type="protein sequence ID" value="KAG7156235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIF3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="110" mass="11567" checksum="4883C83B31C161C8" modified="2022-05-25" version="1">MLVVEERVDTGYGDVKLCNVLFEGRIGVVSGSDGGRASGYSATEMGAKGGASGVGYVPRGKSKEGDDQVLCIYLGGYEERKRHVDDGAGNNRGGCSIPRDSVFVGELFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JII1</accession>
    <name>A0A8J5JII1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038603">
        <property type="protein sequence ID" value="KAG7156821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JII1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="503" mass="54511" checksum="D1413BAB07F9177C" modified="2022-05-25" version="1">MRGVVEEGRSRASTSSKVSKIAGMFQGSGGGGGSRAAPEEEASTTTVSTAGGGDGPSYATVVRTESHLARFNNARALFEKMGQGDSAQPKVVAPVKAIPSASLTKTEVKPEVKVVSKFETKIDPGTTEAKKSSFPTTTTTTTTTTTTTTARPGVTTHHLRRTLGDTLGSEEQGRGRSPRGDSVSPARSAGEASSSSSRSTSPSPARTTNGHTHQDGVGPVGMGLGMANLGLRRPGSASSRSLSTSSTESDPPRRWPPGKVADSKLASKPESVKSEQLSASELRRHRPEKPAKPESLERKFSTHEQHQELIARHKNWFQSFSKNRSPASSPCKGEPRPNSPCKGDGIPPLLVRSDDGRPTSPPKHDWKSSHISKLDLRSPRGVSSSDDYDGTEERSSEREERSSEREDRSSEREDRSSEREDRSSEREDRSSEMEERESEEGVSSTRTASDQDAWSSVLQSRYGPRAKDILSPRMYFCVYVSDMTCCSVQWGGPERLFRELREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIN5</accession>
    <name>A0A8J5JIN5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="13">GNT-I</shortName>
            <shortName evidence="13">GlcNAc-T I</shortName>
            <ecNumber evidence="13">2.4.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Hamer_G019769</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11456"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="2.4.1.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">The cofactor is mostly bound to the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.101" evidence="13"/>
    <dbReference type="EMBL" id="JAHLQT010036095">
        <property type="protein sequence ID" value="KAG7157906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIN5"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003827">
        <property type="term" value="F:alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047223">
        <property type="term" value="F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052463">
        <property type="entry name" value="O-linked_mannose_GnT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396:SF1">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7157906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="477" mass="54899" checksum="69A5C4E0383687C0" modified="2022-05-25" version="1">MFPNLTSPTTTHPPSLRDYMPSHAYTSSNTRSNNSTGPLRHQQEQTPPLQEVSRGRVWGEAVTTIRRPDGIFGYPLSMDTRVPKVSGVWCKWHEDPHMQEQREFCDTYEGYVTLCTCVHPVTASVRQSAPEITMNEIIPVAMLTAIKPFNFYRQLLNLLETPGAAQTPILVMVDGANTEILRLVRLFGLDVLVHRPQGAPGTTTLLNMHFRFSVHNVFNFFPEVDKAIILEDDLLLSPDFLSFFQQTAWLLDADPTIFCVNAFSVNSYREVAWDPTLLRRINMFPQFGWMISRRWAREQYRAWISEKQTGDWDWWLSSENSLQGRHALVPEVGRTYHAGAAGAHTGIFRMFIASETKSDEYNSFYVMQLCLRGFVQDSREKYNGAVRFNLQGRVLYIIGCPASPYCLLFPKGVSILKPSPELILIAERSSQKWQTRNYPPYYLQRSYVRDPHQEFLMENLLYRYWNGTFVDSTGATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKT4</accession>
    <name>A0A8J5JKT4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox protein SIX6-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SIX6-L2</name>
        <name evidence="11" type="ORF">Hamer_G025008</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036553">
        <property type="protein sequence ID" value="KAG7157871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKT4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000046">
        <property type="entry name" value="SIX homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF33">
        <property type="entry name" value="PROTEIN OPTIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="273"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="275"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="54"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="324"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7157871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="366" mass="40627" checksum="46DB677E55194D73" modified="2022-05-25" version="1">MDKSECDRGQLVAAAGSGGDTRAPPPGDGKPGDLSDSAHSALYWRTTLLLTNERRASSRGGGAVHTATNDRAVSSKAGVQREAPPHVTAPLSTSPGLHYYRERRDSNTWCNAVECVRHTMVLGLAANVSASSGSSVGGSGGPVVPTPIVALPSLSFTAAQVAAVCETLEESGDMERLGRFLWSLPVAHPHLHDLNKHEAVLRARALVSFHVGNFRELYAIMESHRFSKPSHARLQALWLEAHYQEAERLRGRPLGPVDKYRVRKKFPFPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELASATGLTPTQVGNWFKNRRQRDRAAAAKNRQHTELNLVSHGTDTKTRSHRWTRPESMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKY8</accession>
    <name>A0A8J5JKY8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">THEM6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Them6-L</name>
        <name evidence="2" type="ORF">Hamer_G012774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKY8"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="195" mass="22534" checksum="572338AF04A01963" modified="2022-05-25" version="1">MVELYTVALGLLVTLDLGYFLKTFIFGIHSKFFSSRIHVLAPSKLYGICTTRDIDFLLNHINNARYLRAMDFGRVNHCIRAGIFQALTRKNTKLLVAASTIRYRKPVYLFMPYMLHSQLVYWDERNLYYRQDFETIHDNFLRATAYVKLAVVGSNAEGILSAVLSESPVRPEAPSDLLSWIQYNEQSSQNLKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JP32</accession>
    <name>A0A8J5JP32_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aurora kinase</fullName>
            <ecNumber evidence="14">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Aur-L</name>
        <name evidence="17" type="ORF">Hamer_G013989</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="14"/>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JP32"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="104"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="182"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="11">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7161356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="371" mass="42739" checksum="6F4D898603104BA8" modified="2022-05-25" version="1" fragment="single">QQCVFKTRRASTNQRPAGRFKPPDVHIQRGGEGDDPPSLPFYHLSPLFNTSSTIYYPLLFRVIVKEVFVRGVKGSIAESGSGNADQQRKQCRDKDKQKWSLDNFEIGRPLGKGKFGNVYLAREKSSKFIVALKVLFKSQLQKSNVEHQLRREIEIQAHLRHPNILRLYGYFHDAVRVYLILEYAPRGELYKEMQAQPHSRFDEKRSAKYIMQLANALKYCHTKKVIHRDIKPENLLLSLRGDLKIADFGWSVHAPSSRRTTLCGTLDYLPPEMVEGKAHDEKVDLWSLGVLCYEFLCGKPPFEAESNSDTYKRICSVDLRFPSHVSDKAKDLMVKLLRHSPRDRLSLDGVLQHPWIGQWTEDRSTVPPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPH3</accession>
    <name>A0A8J5JPH3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G017420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7159978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPH3"/>
    <dbReference type="OrthoDB" id="10620740at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035271444" evidence="2">
        <location>
            <begin position="22"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="235" mass="26102" checksum="80AB9965AEE3CF99" modified="2022-05-25" version="1">MRTVLMAMVVAAVNLQHWTMARHSECKVNLTEPLNLNLSSSKVESEEILWGEISVFPGPDNQSWVLNFTFRRADELLASVFVSHMRRNGSLSQLDVIRIVCEGNEPVDMDDPWPDPWLQATPRLIKVMITETEVVIKQKERNVFTHICTGKLTSLHNMSLTVESDPCCPAPTLTVSCDTDNGAVLPASSHPFLLWLIVVFGVVGGVLLGLMMGGVLLASLDSYYIMGDLKEHQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ92</accession>
    <name>A0A8J5JQ92_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxisome assembly factor 2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Pex6-L1</name>
        <name evidence="2" type="ORF">Hamer_G010746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQ92"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="1">
        <location>
            <begin position="406"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="622" mass="69020" checksum="35F8081F885805D5" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JR95</accession>
    <name>A0A8J5JR95_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JR95"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="185" mass="21534" checksum="9D4BEFF8AC1E5937" modified="2022-05-25" version="1" fragment="single">HREGGEEEEEEGEEDKEEEEEKGEEDKEEEEEEEGKEDKEEEEEEGEEDKQEEEEEGEEDKEEEEEHGMVSSLQTRTERLTACFATKLITRARESDIKNGLLRALNLNRDVFHKKIWLLCTADVVNRLELKDTILRKGPDTRSPDYSTPAPWESPPAVFNILQTGTRKADCNPHELRHVAERNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRB7</accession>
    <name>A0A8J5JRB7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coiled-coil domain-containing protein 124-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Ccdc124-L</name>
        <name evidence="6" type="ORF">Hamer_G020352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCDC124 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036764">
        <property type="protein sequence ID" value="KAG7157809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRB7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil" evidence="5">
        <location>
            <begin position="129"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7157809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="215" mass="24776" checksum="597AFAB5E6CD76BE" modified="2022-05-25" version="1">MTQGFINKKMPKKFQGENSKAAIARARKADIAIQEKQKKDQIQEDALWEDNDKHIKKKTARKEDREKKRQAELERKALNRALAEIEEVEVNVPQPTPQKKIKEKQTEQQSRKVATEDSQTHLDVPLVENLNRTDDEIVSASGVDAAIAALSVQDDSSDRHPEKRMVAAFKAFEAVRLPQIKKENPNSRLSQQKQQLRKEWQKSPDNPINKRQLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRJ0</accession>
    <name>A0A8J5JRJ0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026572">
        <property type="protein sequence ID" value="KAG7162900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRJ0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="148" mass="17019" checksum="3E5DAF039C89991B" modified="2022-05-25" version="1" fragment="single">KRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKIPPINVNAIKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSD2</accession>
    <name>A0A8J5JSD2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome subunit alpha type-5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Psma5-L</name>
        <name evidence="5" type="ORF">Hamer_G016227</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSD2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="4">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7161178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="302" mass="32810" checksum="0EC2E0A4F7745FD2" modified="2022-05-25" version="1" fragment="single">MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVVLAVEKRITSPLMIPSTIEKIVEIDRHIVNLAVNLNLKMLLSCRPGFSTPSRTPCGHLSSATPAILAQAIVSLQASLASMSAPRQSSQPRVSMASAPKKYDLEMSSAAFRSWGRSTECWLQLNKWPDADAVLHIRLLCVPVLQRCAVSGLVADSRTLVDHARTECANHWFVYNENMKVESVAQAVSNLAIRFGDSDDDGPAMSRPFGVAMLFAGLDKSGAQLYHMDPSGTFLEFGAKAIGSGSEGAQQSLQESYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSL6</accession>
    <name>A0A8J5JSL6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trafficking protein particle complex subunit 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TRAPPC8-L</name>
        <name evidence="6" type="ORF">Hamer_G004566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058541">
        <property type="entry name" value="Ig_TPPC8_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058538">
        <property type="entry name" value="Ig_TPPC8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058540">
        <property type="entry name" value="Ig_TPPC8_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057651">
        <property type="entry name" value="Ig_TPPC8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24545">
        <property type="entry name" value="Ig_TPPC8_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24544">
        <property type="entry name" value="Ig_TPPC8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24546">
        <property type="entry name" value="Ig_TPPC8_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24542">
        <property type="entry name" value="Ig_TPPC8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPPC8 first Ig-like" evidence="4">
        <location>
            <begin position="645"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="TPPC8 second Ig-like" evidence="3">
        <location>
            <begin position="845"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="TPPC8 third Ig-like" evidence="5">
        <location>
            <begin position="966"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="TPPC8 C-terminal Ig-like" evidence="2">
        <location>
            <begin position="1195"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7163422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1344" mass="149242" checksum="746F4784CEF609EC" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTV9</accession>
    <name>A0A8J5JTV9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016414</name>
        <name evidence="1" type="ORF">Hamer_G026568</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025516">
        <property type="protein sequence ID" value="KAG7164222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTV9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="104" mass="11427" checksum="495F603DC9CFEB15" modified="2022-05-25" version="1">MLRWCYTCCRGSVAPVELVGVSAAGGGSTDFLLLWCFNTTGGRQDGRHHRHKGISSSEATSPEMTFLVVERESEVELDKLPRRSVRKFRQEAAGRKVASTTTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTZ5</accession>
    <name>A0A8J5JTZ5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028102">
        <property type="protein sequence ID" value="KAG7162048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTZ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="98" mass="10608" checksum="9BB5F111091A4F9B" modified="2022-05-25" version="1">MSRGRPTRCVAPGGRGGHCPEALKHPQHSSCRSVHPVSSGRVNFISQDRPHYTTVHTGRRSAGLLGICLHGLSQAAHRQFIHGPHLSREGSCTGPYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUG6</accession>
    <name>A0A8J5JUG6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mismatch repair endonuclease PMS2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA mismatch repair protein PMS2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PMS1 protein homolog 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Pms2-L</name>
        <name evidence="17" type="ORF">Hamer_G016255</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUG6"/>
    <dbReference type="OrthoDB" id="10254304at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000032">
        <property type="entry name" value="mismatch repair endonuclease PMS2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.20:FF:000019">
        <property type="entry name" value="PMS1 homolog 2, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="16">
        <location>
            <begin position="236"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="15">
        <location>
            <begin position="804"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="433"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="584"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7161203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="989" mass="109726" checksum="C92AE64C0B322912" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWF2</accession>
    <name>A0A8J5JWF2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWF2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="119" mass="13254" checksum="24E0568A496F5A31" modified="2022-05-25" version="1">MATNMLPPQYQQWRPTTTCYLHNASSIAANNDVLPPQYHQCGGQQPRVTTSSDGQQPRVTSTIPVVWRPTTTCFLHSTSSVAANMLPPQYQQWRPTTTCYLHSANSVAANNHMLPPQCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWM9</accession>
    <name>A0A8J5JWM9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Ccdc43-L</name>
        <name evidence="6" type="ORF">Hamer_G023921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027355">
        <property type="protein sequence ID" value="KAG7162704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWM9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037666">
        <property type="entry name" value="CCDC43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058771">
        <property type="entry name" value="PWI_CCDC43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26091">
        <property type="entry name" value="PWI_CCDC43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC43 PWI-like" evidence="5">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7162704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="223" mass="24994" checksum="BCED6AAB25847F04" modified="2022-05-25" version="1">MAEALACDFDDWLKFTLVALNTDDEVFSPYIKGILEGDENAEEKLEALQGILTEITENGIDDLCQDILKKWNLRDDSCVEDVSVQVRPLREEGHVEDVSVQVGLDEKLAKIMGEQAQCVVTTKSRSRDEENLKSAILAQYSQVSDGEVTDSDQEEEGSGGLGIRNTNAEEVIKAERRRDKDKEESQRKKEKDKEDSYLVMLGSLVLVVEHHVMQIVGIRSVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWP2</accession>
    <name>A0A8J5JWP2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spaetzle 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Spz2-L</name>
        <name evidence="7" type="ORF">Hamer_G002783</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWP2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF12">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035149381" evidence="5">
        <location>
            <begin position="18"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Spaetzle" evidence="6">
        <location>
            <begin position="207"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7163578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="306" mass="34569" checksum="1B91B4955FEA8622" modified="2022-05-25" version="1">MVLVVVMIAACVVVTQGDPEASTPKYDPPVYPRPRQADALSDHTTDDEVKKAICNTCRNICRIKFYHVFNVLFSAFPATPNTDREPLLRSSKILPFLPERYLGSLGVIPGPVGVSLGLGVPVASPPIPDVLHNPLVPGNVRGPRPVCAGSGTYCLYDNNYPLDKVNAISDRFYNDIRHIYSNLYRFHTNDIVYYDNATLHYRNDGHFVCESSVQYVRPGWAQNVRGEWLAILNTDKFPQTIRTEICRYGGKRCEYLPPCYKSRCAQRFSYVRLLCVDPYHPSIKPVVDVFPIPTACSCFVEDFTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWZ9</accession>
    <name>A0A8J5JWZ9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWZ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="464" mass="52285" checksum="E8D502EAE55553D5" modified="2022-05-25" version="1">MGLEVDDDDVEELVEEHSKELSTEELLELHKEQNETLKRSLTSEESGEEEDKEESCIIPAKDLKDAFFCWSKLSKLAEDYHPDVGSVQKAISVFNDNVMNYFWKVLTSVLLRQAYYQTCPWAQWLLLATLEILHGHPVPKLDSDTLHILQGTEKGLNSLDNQNFTHAVDSELKKGPDACPGNDLKSKNETVPDGKTTGIERYKSTRRKSARNTAFPHVEETIHSNWVSNKHASVEKKVLCKDVGVQVTPRIMDTTCTKCVGVEVSPGIMGITSNKLVQVKNGLQIPQSSQTKGSMDTRDTESQTEERELLKSFSRICSDKEVQTHFIRSNYSSTPPELGEHFAKMRWKLFPLSGLPERKLAGKSMYNVYANAPPVQFLKDSFVTNKDTEVAVYPEKMTDLMKFKSSSSTEECNIPVNKELNIRLFHGRPLVDSRSKKDAAGIPIERISGLVDLGLQDPRQLKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0B8</accession>
    <name>A0A8J5K0B8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0B8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="80" mass="8842" checksum="97EBF5A8A2F4D2E1" modified="2022-05-25" version="1" fragment="single">LAQCSELCWQLLVRQQSARSLGKDCRSSYKSCRRVQECAIFNAIQDALEADGPALINKVKGFIASKLRVVLVVVKPNGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0F1</accession>
    <name>A0A8J5K0F1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G010209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0F1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035166957" evidence="2">
        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7167807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="332" mass="36251" checksum="CD6588B6015061B2" modified="2022-05-25" version="1">MMFSPELVTAAVVFLTVVTAQKSVTIDDASKTTLDQWTSDEDTSEVKPGDTGPLIDILQHQQEYDTIPTDDFLDPGDPDHLYYDDDDYDDSEDGNNDDDDNGLDLDSEEDEDDSKGHESNDRFKRKVIFGGGGGYSGVGRRGGGSDPYSRRRGGGQGNGPDYGVNDYSWPFRSRNEDIPTASHNGGSSDTSSSSSTSSSSPSSSSTSGTSSRSSDIADSPAVFGTPVASSASTITGTSRSLGNSRSYGITHTSDTYDSPSTSNRKSKTGRREVKKKLSKNQKWEIAQYALNHSNEEAAERYGRLVDRRLSVKKIAKFVKRYQQRLLKNQRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0K7</accession>
    <name>A0A8J5K0K7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Pde11a-L2</name>
        <name evidence="2" type="ORF">Hamer_G003490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0K7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="227" mass="25372" checksum="59233FB59FB33C5C" modified="2022-05-25" version="1" fragment="single">MTNLSFSTVEEWLDKHPDLAADYFVRKAELDAVNKWLVAHGFLTVTQGSSSRRGSASLSCSPIVSPSSPIDKISDSPFNDNDSKTRRTNSKKYLRHNFAKCKSKSVFRTYEPSAASAAAEARRSSFRAMRKYSSLPPSSNYMLCLLIESKVRLPRFQSITLDRKKQLRSQDEKDFFLDIVKDIANDLDLEGLTHKIIVNLSLLLCADGASLFIVQNTSAGKKVLVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0Y7</accession>
    <name>A0A8J5K0Y7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein 845-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Znf845-L1</name>
        <name evidence="13" type="ORF">Hamer_G007331</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="725"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="555"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="932"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="978"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1041"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1395"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1041"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1401"/>
            <end position="1420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7165483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1545" mass="175295" checksum="455871F00292894B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1E4</accession>
    <name>A0A8J5K1E4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Tubgcp2-L</name>
        <name evidence="11" type="ORF">Hamer_G004378</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation. Plays a role in neuronal migration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the gamma-tubulin ring complex (gTuRC) consisting of TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 and gamma-tubulin TUBG1 or TUBG2. TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 assemble in a 5:5:2:1:1 stoichiometry; each is associated with a gamma-tubulin, thereby arranging 14 gamma-tubulins in a helical manner. Gamma-tubulin at the first position is blocked by TUBGCP3 at the last position, allowing 13 protafilaments to grow into a microtubule. The gTuRC (via TUBGCP3 and TUBGCP6) interacts with ACTB and MZT1; the interactions form a luminal bridge that stabilizes the initial structure during complex assembly. The gTuRC (via TUBGCP2) interacts with MZT2A/MZT2B and CDK5RAP2 (via CM1 motif); the interactions play a role in gTuRC activation. Interacts with ATF5; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1E4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000002">
        <property type="entry name" value="Gamma-tubulin complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="10">
        <location>
            <begin position="250"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="9">
        <location>
            <begin position="514"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7163269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="863" mass="99300" checksum="7DEF68E81DD0AB30" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K348</accession>
    <name>A0A8J5K348_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylglutaconyl-CoA hydratase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Auh-L</name>
        <name evidence="7" type="ORF">Hamer_G013662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022272">
        <property type="protein sequence ID" value="KAG7166638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K348"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000022">
        <property type="entry name" value="methylglutaconyl-CoA hydratase, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7166638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="293" mass="31136" checksum="3A761727B14C2FBF" modified="2022-05-25" version="1">MLRGARSSLGILRGVWSSTPARGFCSNRSDVSVEKLTGDHEGVTVFGFCRPAAKNAISRNLLKEFIQAIEDVKHDRSVRVVLLRSLVPGVFCAGADLKERAKMKPEEVGPFVSKARSCISELENLPMPVIVAIDGVALGGGLEMSLACDLRVAADSAKLGLVETKLAIIPGAGGTQRLPRIVGSAKAKELIFTAAVLDGRQAAEIGLVNHVTSQNETGDAAYLKALEIAKAITLNGPIGVRMAKTAISKGMEVDLGTGLSIEEACYAQVIPTKDRIEGLTAFREKRKPIYKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3K8</accession>
    <name>A0A8J5K3K8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019608">
        <property type="protein sequence ID" value="KAG7168676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3K8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="131" mass="14350" checksum="8647E8630DA7FF65" modified="2022-05-25" version="1">MAAADEYSTTSHVLQLCLALQDRLEKVEKEVQSLKGENLALKLVLEEKKTFASVVKDGEVEVDSWKVVAASATKCAIKRHSAVDLNNRFSTLSDECEEGASNTTSATPSVSVERGSSAVRSNVFLSWETRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4C9</accession>
    <name>A0A8J5K4C9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G005069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4C9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035302032" evidence="1">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="99" mass="11153" checksum="13B147C1DBD61635" modified="2022-05-25" version="1">MKSCIILLVFSLAACVLSEPSPHHIPGHKCNPCVPADCKPVTPCAFGITKDTCDCCDICRTKFRDSHAHCHDPHAEDHAEFDHHHTEHEEYCREQGHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4W8</accession>
    <name>A0A8J5K4W8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc transporter 1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Slc30a1-L1</name>
        <name evidence="12" type="ORF">Hamer_G013492</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4W8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010312">
        <property type="term" value="P:detoxification of zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="75"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="238"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7170672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="530" mass="57820" checksum="6B23FF50A807670D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5Q5</accession>
    <name>A0A8J5K5Q5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase zeta catalytic subunit-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Rev3l-L1</name>
        <name evidence="1" type="ORF">Hamer_G018450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7168014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5Q5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="103" mass="11764" checksum="7DE7A38E48CCE762" modified="2022-05-25" version="1" fragment="single">NGVINNKVYQPHESHVPYVLQFLMDHNLHGMNMIHLATCRFRRSQGTRGPFPCWCIGRNSHRAVIARPSRHQHLLAAEHHGMDERECTAAPVVARNSLQNGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5X3</accession>
    <name>A0A8J5K5X3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAM and LDL-receptor class A domain-containing protein 2-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Mlrp2-L7</name>
        <name evidence="3" type="ORF">Hamer_G016764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020459">
        <property type="protein sequence ID" value="KAG7168134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5X3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="57"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="241"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="418"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="601"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7168134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="780" mass="86322" checksum="E12AE7579A15EF73" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6P4</accession>
    <name>A0A8J5K6P4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kelch domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Klhdc3-L</name>
        <name evidence="1" type="ORF">Hamer_G002663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6P4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052637">
        <property type="entry name" value="KLHDC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46461">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46461:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="277" mass="31724" checksum="2035A579371D8105" modified="2022-05-25" version="1">MLWTVELEGGPQRVNHAAVPVGEKIYSFGGYCTGENYRTIRNMDVHILDTVTYRWKAIEIRQERKCVPFQRYGHTAVAFGHLVYGQAPVYRDFHTATGVDGVMYVWGGREVKSGLYDSPEHEEYGSDLYALDTTASRWSVVHCSGCLPIGRRSHSAFVYRGQIYIFGGFNGREECHFNDLHRFDPSKCDFDDNDPKDNVEEVTALEDDVYGEELTDRRLKDHNDLHVLDFEPSLKTLCLIQVQTLKLDTTWLPRELQALLEVMSMPNTITRPLNHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7V4</accession>
    <name>A0A8J5K7V4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox protein abdominal-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Abd-B-L</name>
        <name evidence="11" type="ORF">Hamer_G020647</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Abd-B homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018130">
        <property type="protein sequence ID" value="KAG7169166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7V4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000166">
        <property type="entry name" value="homeobox protein Hox-C11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046333">
        <property type="entry name" value="HXA10/ABDB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="65"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="67"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7169166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="165" mass="18809" checksum="6C4B5DDD2B50D07C" modified="2022-05-25" version="1">MGRNGERGMKGKEEEEEEEEEEREEEEEEILFPCPRVPVSPCPRVPVSPCPRALGSIPQEWTGTMTVRKKRKPYSKFQTLELEKEFLYNAYVSKQKRWELARNLNLTERQVKIWFQNRRMKNKKNSQRQAAQEAANGAGGGTPSSGGGTPGHQPNTPQTPNTIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K834</accession>
    <name>A0A8J5K834_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative 28S rRNA (Cytosine-C(5))-methyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020160">
        <property type="protein sequence ID" value="KAG7168283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K834"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="189" mass="21752" checksum="62B340AA1C0E42A6" modified="2022-05-25" version="1">MIVCRFQPTICTSQHFSIIPGSVHAQLADEGWQLQEYDPTQVTYDDYLHLIQNMDETTYLIDYHIPVAGIPTQHPFWNSILYNKNAIILQNKVIFRSHEHAERWRERLVENNGREECGETIEDIEGWVKDGLKCWELTSTKKLSQLYSVFLSSVNPGANVIDLVLHQETRPQYISAIMCNSGSILAVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K874</accession>
    <name>A0A8J5K874_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone H3-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">H3-L4</name>
        <name evidence="3" type="ORF">Hamer_G032242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022272">
        <property type="protein sequence ID" value="KAG7166629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K874"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="2">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="72" mass="8268" checksum="B8A6C4E6E9F2A0B6" modified="2022-05-25" version="1">MSISLCGLPQLGVKKSHRYRPGTVALRVVCRYQKSTELLIKKLPFQRLVHEISKDFKTDLPLPVVCRHARNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K875</accession>
    <name>A0A8J5K875_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA recognition motif-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G031511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013132">
        <property type="protein sequence ID" value="KAG7171031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K875"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="132"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7171031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="292" mass="34429" checksum="60463629CA76C133" modified="2022-05-25" version="1">MGDLCTRLENFHLDSGEGRSSEVKPNVFTLNLVILKTEPEDTNKKTAVKWDNDVTKAKFLQRCKHQVKVETAEVDLIDTTSKSDLIVRSERKECKNRSTPYDRNNKRQPCPPQPRPYSKGNQDFHRYDQFGLFIKNIPPGVTYHELRSLFGRHGGLMHFYMPRKHGGTAVARYCNEHYRKLGLTLDGYPVGGEDHYKNSRRFLHVNHLRYSGASFKDPQVSRTTSHKRCLEEDRSSQYQSSRYDRYPEDEYSSKRYRREQYEDEDDSPRPCRNCSSYRRQRPAPAYKWVRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8Y1</accession>
    <name>A0A8J5K8Y1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">BCS1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">bcs1l-L</name>
        <name evidence="18" type="ORF">Hamer_G013471</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8Y1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="17">
        <location>
            <begin position="23"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="223"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7170652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="423" mass="47814" checksum="041F902D40B92676" modified="2022-05-25" version="1">MGFQDLISSLSDNPYFGAGFGLFGVGAGAAVLRKGYMMGMILFRRHYMTTLEVPCRDKSYHWLLQWITLRGARKTQHLSVETKFQEIETGKITTRHDFIPSVGEHFFWYKRTWIRVERSRSQQTLDLHMGVPFETVKLTAFGKNKDLFIDILEEARDLAVKQNEGKTIMYTAYGSEWRQFGNPRKPRPLTSVVLDEGVSNKIVKDVKEFMDNPKWYSDRGIPYRRGYLLHGPPGCGKSSFITALAGELQLGICVLNLSERGLTDDRLNHLLALAPEVLKAAYAGLNRLTFSGLLNCLDGVASTEARMMFLTTNYPERLDPALIRPGRVDMKEYIGYCTTHQLETMFCNFYPDVSGLASTFSQASGNLGVPLSAAAVQGHFMIYKEDPLGAVHNVIHMATENVIRRDTIPMNRENSVFDIKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KFQ2</accession>
    <name>A0A8J5KFQ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cysteine-rich, acidic integral membrane protein-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CRAM-L4</name>
        <name evidence="1" type="ORF">Hamer_G031403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012665">
        <property type="protein sequence ID" value="KAG7171224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053359">
        <property type="entry name" value="CRAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35577">
        <property type="entry name" value="CYSTEINE-RICH, ACIDIC INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35577:SF2">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1536"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1536" mass="172254" checksum="F966E1FA75400C9F" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MFX4</accession>
    <name>A0A8J5MFX4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable nuclear hormone receptor HR3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear receptor subfamily 1 group F member 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Hr3-L2</name>
        <name evidence="14" type="ORF">Hamer_G010663</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Putative receptor whose ligand is not yet known.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MFX4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000003">
        <property type="entry name" value="Nuclear orphan receptor ROR-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805:SF2">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="43"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7153353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="137" mass="15176" checksum="11BFF315130444ED" modified="2022-05-25" version="1">MTGGSSMPREAVGDWRAIGQRSSDVTEAGNLASHSSASAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRQKNCVVDRVNRNRCQYCRLQKCLALGMSRDGETARDSWAGYINRDRKTCPFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK94</accession>
    <name>A0A8J5MK94_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MK94"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="103" mass="10833" checksum="92B2144EAB29A9F0" modified="2022-05-25" version="1">MEVMVEEWVLEVMWRSGVLEVWGGGVVSWEVMVEEWEGGDGGGVGHGGGGDAEGEGGLEGVGGGVVSWRGRWCPGGVGGRSGVLEVMVEVWSWRSGVLEVMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK95</accession>
    <name>A0A8J5MK95_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G026812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044381">
        <property type="protein sequence ID" value="KAG7154519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MK95"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883:SF12">
        <property type="entry name" value="SEA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883">
        <property type="entry name" value="YIPPEE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="555"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="897"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1097" mass="113913" checksum="E8BC79361E5B9F17" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLS3</accession>
    <name>A0A8J5MLS3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039989">
        <property type="protein sequence ID" value="KAG7156124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLS3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="242" mass="27647" checksum="23AD45E39D4748C5" modified="2022-05-25" version="1" fragment="single">PLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQKTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEVIQREEELCQDKSSPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNG0</accession>
    <name>A0A8J5MNG0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein 6-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Mfsd6b-L</name>
        <name evidence="9" type="ORF">Hamer_G018766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036987">
        <property type="protein sequence ID" value="KAG7157700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNG0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="45"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7157700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="314" mass="34099" checksum="5483D5A756BA2BCF" modified="2022-05-25" version="1">MRKMSGADASWPINAQLTKSSTNHKKEKSAESDAPSLGSNERKIFMSVMYALQGIGTFLFTIVPSATATTTTTTTNGGDLFNGTTAYAINSTTHNSNNTTLIDVIIINNINNSMMGGYAETYMYRYLYNLGGNTVLISLTVTLGAPFECFFMLVTSYFVSLIGHAPLIMIGLFAYVIRLLGMSFLKDPWVVLLLEIVESMANGSLNTVAILYCTVLFSMESIASCRGLLGVMNNGVGRLLGTLLGSIIREALGDRVTFRVLAAGGMVFCVLYCLAFCLLKRYRYKAFSVKTSSLPARQQASRQGATNHACNVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPE3</accession>
    <name>A0A8J5MPE3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-arrestin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Arrb1-L</name>
        <name evidence="4" type="ORF">Hamer_G006294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPE3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.840:FF:000003">
        <property type="entry name" value="Kurtz arrestin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017864">
        <property type="entry name" value="Arrestin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF17">
        <property type="entry name" value="KURTZ ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00309">
        <property type="entry name" value="ARRESTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00295">
        <property type="entry name" value="ARRESTINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="234"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7158916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="571" mass="62157" checksum="E829B1BE9AFD7DF3" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPT5</accession>
    <name>A0A8J5MPT5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033603">
        <property type="protein sequence ID" value="KAG7159306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPT5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="125" mass="14397" checksum="71E93C3C7BBAD4F1" modified="2022-05-25" version="1">MEKEDIVAARNKYLRYIQKNRESSNPRPEVYLDETWINQNQCVERCWTVNDGSAGPKLKSGRGARFIIAHAGGRQGFIPGALLMFRSKNGAKGDYHDSMDHERFKAWFKEQLLQNIQRVAARSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQ13</accession>
    <name>A0A8J5MQ13_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase cyp11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cyp11-L</name>
        <name evidence="8" type="ORF">Hamer_G021237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033646">
        <property type="protein sequence ID" value="KAG7159292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQ13"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052667">
        <property type="entry name" value="E3_ubiquitin-ligase_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47156:SF10">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM-21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47156">
        <property type="entry name" value="PROTEIN CBG20824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="16"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
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            <begin position="379"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7159292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="523" mass="58856" checksum="4C2C537612F64BD0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQ46</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">Hamer_G004319</name>
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    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7159636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1118"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1324"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1566"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1743"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="1900"/>
        </location>
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        </location>
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            <begin position="2278"/>
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            <begin position="9"/>
            <end position="23"/>
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        <location>
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            <end position="2069"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7159636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2333" mass="252609" checksum="D3AE3B53DC3481E0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQ84</accession>
    <name>A0A8J5MQ84_HOMAM</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Multicrustacea</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7159773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="406634at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF33">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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            <end position="431"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7159773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="454" mass="51414" checksum="018C49C6C1E3E263" modified="2022-05-25" version="1">MSCQRYSRLVLSGAAAMRTVTHQQVRRNCNNCNKRGLSLVSCARQQVAIKESPVSGAARSPALKGITPSATDLVASLPDQEGLNVKFGDGSASQMPYVWLRDNCQCSKCYNPVALGRSFLLEDLDVNVHATKVQESEDGVEIEWSDGHSSQFTAEWLYDRAFTTSARAQQRNRYALSREPWGVEHKPAEFDYQTLMEDEKVLLDWLLTMETKGSALVKNTPNRDVAGPDLINNIAFVKQSHYGPHSPVINRENTNNVAFTNVKLGMHNDLAQYEQMAGIIFIQCVMQHQGKGGESVISDGLLAAECLRRDHPEAFQVLTTTDAYFWDKGHANFPWEMESFFKISKRPIITLNNDNEVVCVAMNNGVRHSYLDLPSHKVKKFYAALKLFNDILYDNAIRFKMEAGDMMTLDNIRCLHGREGYEDFSPRHIESSYLDWDEALCRRRRLQEKLGLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQ91</accession>
    <name>A0A8J5MQ91_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G004136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQ91"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="89" mass="9479" checksum="48CA1F0817951A14" modified="2022-05-25" version="1">MVAASNMVVAEVGVATKDLVVANTDMVVTTSKLVVATTDMVAATSEWRCQTDESVLEHPSASFTKTGRKHKCHIGRAVSTSDTLLKQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRD8</accession>
    <name>A0A8J5MRD8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030678">
        <property type="protein sequence ID" value="KAG7160806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRD8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035213438" evidence="1">
        <location>
            <begin position="22"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="100" mass="10342" checksum="56159298C5645092" modified="2022-05-25" version="1">MNCCGGTNVFVFLGRIGVVSGSDGGRASGYSATEMGAKGGASGVGYVPRGKSKEGDDQVLCIYLGGYEERKRHVDDGAGNNRGGCSIPRDSVFVGELFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRW9</accession>
    <name>A0A8J5MRW9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Rpl7-L</name>
        <name evidence="9" type="ORF">Hamer_G023059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029514">
        <property type="protein sequence ID" value="KAG7161314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRW9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="8">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7161314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="270" mass="30894" checksum="2F3FEE9CE342CC0E" modified="2022-05-25" version="1" fragment="single">ESKAAPANRVRQRKKRPTDPALRKKVAPTARKVAPPSAKPKKVVVPSKIKLKTKPLPRPKKIAPKPKTDAGKKLPAVPEVLLKRRKRRSVQKKTRITAVIQAKKALKAKRFNIFRRAESVNQIHPKVRKVLQLFRLLQINNGVFVKLNKATINMLRIAEPFIAWGYPNLKSVKDLVYKRGFAKVNRRRVPLTDNRIIEDNLKSKEIICMEDVVHEIYTVGEEFQAVTNFLWPFKLNNPTGGWRKKTTHFVEGGAFGNREDQVNTLLAKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MS99</accession>
    <name>A0A8J5MS99_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029328">
        <property type="protein sequence ID" value="KAG7161466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MS99"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="247" mass="28336" checksum="E250E9825F2C8611" modified="2022-05-25" version="1" fragment="single">PLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPISVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVKRCVKMVTEAAGHVYSHERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MT70</accession>
    <name>A0A8J5MT70_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger and BTB domain-containing protein 7B-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Zbtb7B-L3</name>
        <name evidence="11" type="ORF">Hamer_G008035</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MT70"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000260">
        <property type="entry name" value="Spalt-like transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7162486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="127" mass="14436" checksum="8FC6B9D214930708" modified="2022-05-25" version="1">MQVRMARGDHRTSKLGVPGDRPRLPSIHIREKPFYCSLCPYQMSNDSTKRHQCSHIGKVPYSCPYCPFRASHSSKIQCHLRTHTGEKPYACHLCPSRFAKKGNLKTHIRTHTGETICMSPLSILLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU89</accession>
    <name>A0A8J5MU89_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="13">GNT-I</shortName>
            <shortName evidence="13">GlcNAc-T I</shortName>
            <ecNumber evidence="13">2.4.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Hamer_G019105</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11456"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="2.4.1.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">The cofactor is mostly bound to the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.101" evidence="13"/>
    <dbReference type="EMBL" id="JAHLQT010026149">
        <property type="protein sequence ID" value="KAG7163836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU89"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003827">
        <property type="term" value="F:alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047223">
        <property type="term" value="F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052463">
        <property type="entry name" value="O-linked_mannose_GnT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396:SF2">
        <property type="entry name" value="ILEI_PANDER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7163836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="528" mass="60365" checksum="752F42DA9ED42E53" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXP9</accession>
    <name>A0A8J5MXP9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate receptor ionotropic, delta-1-like 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Grid1-L21</name>
        <name evidence="16" type="ORF">Hamer_G012896</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXP9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035277247" evidence="14">
        <location>
            <begin position="22"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="221"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7167436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="487" mass="54865" checksum="FD2F0C256E10C4B6" modified="2022-05-25" version="1">MVSQAPALSITLLLWLWVAAATPPIPSRSVYQPEELLLDLVSGPLQGRSIFLLHDSQSGFEVNLNQVLSHISSSMVMIANQENFSMDQYPSGYVRGENYVAVMLFSSSPTNFLNYLSESNVWNPTFLILLAMNTSIDTTEVVSHAVVQRSRYLVLFEQHVVNISKVFYMFTSYPFSPEGHRATLGSWSNKTITSVVDLFPDRYPDLQGAVLYLASWCDDFPIIYVSGDGCIGSSLDTLSLIAHKLNFTYEVQRETQDQHWGALENGNWTGMLGDLKYNGKDLALNWFLLNHNRWKAFDALYPYYAEGFGFLARLPEPAPRWKNLTYSFTTNLWLIIVCSTMVVSCMFSALMPRHMTEGTVDHIQQIILVCAGVVRQVVDLGGDGRWAWQRVWLGWWWLGCIILTTAYTCNLIAFLTVPVYTTRIETVAHLAASDLRSFLQLVSIPLQESTMQALSIKHLQGAFLLHLLGLVAALLILLLELFVFCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0A9</accession>
    <name>A0A8J5N0A9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pol Retrovirus-related Pol polyprotein from transposon-like 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pol-L11</name>
        <name evidence="2" type="ORF">Hamer_G018049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015512">
        <property type="protein sequence ID" value="KAG7169792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0A9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052160">
        <property type="entry name" value="Gypsy_RT_Integrase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47266">
        <property type="entry name" value="ENDONUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="419"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="461" mass="50900" checksum="878140BF9D8B8C39" modified="2022-05-25" version="1" fragment="single">VSKVKLFNAVNSQLFGDSVDVGSREDHGEVSQVNVAESSSLNDELRLLDYCGKPGHKAKCCWTRLQLNTGKPAMIITEETNTSPVGVMAGLSKADSMPIGLISTKGEARESAVSVLASRDFDLFQESFEKDPDFGTFRPFLSQGTVEVGVETPVTILRDSGYLQTLIKEGVVAARKTDKYVVLGFLWGQGVVPLVLVRVKSSCFSGIANVACVHELPVTIWRELQQLEDDMHGVFPLCAVTRSMSVTNDHKVTPVVDDSLSLEGLFANPIASQDISSAVNAVTGRVALMAAQEQDDSLRLLFVQVSDSANDSGPTTRYFSQDGVLCRRWLPPTMSEEDTDWASITQIVLPHTYRHVLALVHDSRFSGHHGVRKTFNRLARKFYWPGMRRDVIKYCKYCHFCQKVGKANQAIPPFPLVRVPHVPEPFTTIQCDIVGPLPKTSSGFEYLFTVIDTSTRYLHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0M6</accession>
    <name>A0A8J5N0M6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA pseudouridylate synthase domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpusd1-L</name>
        <name evidence="3" type="ORF">Hamer_G012568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0M6"/>
    <dbReference type="OrthoDB" id="418349at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF87">
        <property type="entry name" value="RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="2">
        <location>
            <begin position="58"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="308" mass="35539" checksum="EF68D4AD29EDF434" modified="2022-05-25" version="1">MSWLDRVAAHILEKMVCLAWHRLVGRISKSLCQLMRQKLGDNVPPGITDLEIVHQSCHYIIVNKRYDVLINSNSSQDEVTVQTQMKQLFPDLASQNLGHEFRFAHRLDFSTSGLLCIALHKKAAAAVAKCFVHKHVDKYYLALVRGHVSKEMLDIYLPIGDDIREEWCGIKMATPLSRHTGRCKAAHTRLLVLQKGLYDGYPATKLLLKPITGRRHQLRVHLSESGHTIVGDFTYSNRRDIYPYRMFLHAYRLVIPSQFESIDVKTEDPFAEHDPRNKWAPVETLHELTKESFVKLKLGRKWYTNKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0V7</accession>
    <name>A0A8J5N0V7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">Pold-L</name>
        <name evidence="25" type="ORF">Hamer_G012431</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0V7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000003">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000351">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="24">
        <location>
            <begin position="103"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="22">
        <location>
            <begin position="203"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="21">
        <location>
            <begin position="502"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="23">
        <location>
            <begin position="972"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAG7170869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1066" mass="121136" checksum="7A57E8F5025D3413" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1A0</accession>
    <name>A0A8J5N1A0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Turtle-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Igsf9-L6</name>
        <name evidence="4" type="ORF">Hamer_G021701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013604">
        <property type="protein sequence ID" value="KAG7170766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1A0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="17"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7170766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="576" mass="61165" checksum="F5BE2E9C72C75226" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2U9</accession>
    <name>A0A8J5N2U9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">stk11-L</name>
        <name evidence="20" type="ORF">Hamer_G009622</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2U9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14119">
        <property type="entry name" value="STKc_LKB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001234">
        <property type="entry name" value="Serine/threonine-protein kinase par-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000235">
        <property type="entry name" value="serine/threonine-protein kinase STK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039154">
        <property type="entry name" value="LKB1_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF94">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 17 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="45"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG7172267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="467" mass="53353" checksum="7D3C2409B68D7D2C" modified="2022-05-25" version="1">MDRDLASDRFMEFDGDDDALLIQRIDSNEIIYCPPKRKYKLVGKYVMGDKLGEGSYGKVKECLDSDTLQRRAVKIMKRKTLRRIPNGDQNVQREIRLLRRLKHRNVISLFHVYHNDEKGKIYMVMEFCVTGLQEMLDRAKDKKFPIWQAHMYFVQLVEGLEYLHSRGVVHKDIKPGNLLLSTDSSLKISDFGVAEQLDVTTGNDEITTSQGSPLFQPPEVAGGARMFPGFKVDVWSAGCTLFNLTSGKYPFEGENMFRLFENICEKPLVVPEELDPVLKSLLEGMLVKDPYQRMSLAQVKVHDWCCKKHPCTDEEVSVGGDDDRHSITIVPYLRYHYYDSESEDELITEHELNGTYKQRQGTKPKIDQTCLLQIFKRRVVPTTRGGDANRSHVLVSNRLLPASSLDTTHVYHIDVVIRQVFSTDRDKGKATARTLPIRHDVTVGPTSTLHRVLSEALGVIWCLLLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3Q7</accession>
    <name>A0A8J5N3Q7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Argonaute 2-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ago2-L6</name>
        <name evidence="2" type="ORF">Hamer_G031275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010637">
        <property type="protein sequence ID" value="KAG7172539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3Q7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="174"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="516" mass="58828" checksum="B38C548BF18FB77F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5Q3</accession>
    <name>A0A8J5N5Q3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Venom serine protease-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G027322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008532">
        <property type="protein sequence ID" value="KAG7173915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5Q3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="106"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7173915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="181" mass="18889" checksum="928D391198552A67" modified="2022-05-25" version="1" fragment="single">MLCAGYDAGGKDSCQGDSGGLAVRRMASGCWQVWCHGAMGVLCPTTQESTFGSLYLDWLKAKTSEGSNDLCFSGQGSGSTTKTPAATTVPSATSCKCGQVNRQTRIVGGQPTEIHEYPWQVALVSSSGSTPFCGASIISNQWILTAAHCAAVMTTSNMVVIGEHKYTSTSETSATERLSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5T0</accession>
    <name>A0A8J5N5T0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G022220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008237">
        <property type="protein sequence ID" value="KAG7173996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5T0"/>
    <dbReference type="OrthoDB" id="10456092at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035310743" evidence="2">
        <location>
            <begin position="27"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7173996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="679" mass="77620" checksum="F98B5603D7949A16" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N600</accession>
    <name>A0A8J5N600_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosome-binding protein 1-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Rrbp1-L7</name>
        <name evidence="1" type="ORF">Hamer_G018001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009070">
        <property type="protein sequence ID" value="KAG7173712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N600"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36912:SF2">
        <property type="entry name" value="ANTIGEN 332, DBL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36912">
        <property type="entry name" value="ANTIGEN 332, DBL-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="473" mass="43973" checksum="CEEB86B77A2BFBB6" modified="2022-05-25" version="1">MEVVLAPGDGVSVVLAPGDGISVVLAPGDGVSVVLAPGDGVSVVLAPRDGISVVLASGDGISVVLAPGDGISVVLAPGDGISVVMAPGDGISVVMAPGDGISVVLAPGDGISVVLAPGDGISVVLAPVMVVVLAPGDGVSVVLAPGDGVSVVLAPGDGVSVVLSPGDGISVVLAPGDGISVVLAPRDGISVVLASGDGISVVLAPGDGISVVLAPGDGISVVMAPGDGISVVMAPGDGISVVLAPGDGISVVLAPGDGISVVLAPGDGIRVVLAPGDGVSVVLSPGDGISVVLAPGDGISVVLAPRDGISVVLASGDGISVVLAPGDGISVVLAPGDGISVVMAPGDGISVVMAPGDGISVVLAPGDGISVVLAPGDGISVVLAPGDGISVVMAPGDGISVVMAPGDGISVVLAPGDGVSVVLVPGDGVSVVLAPGDGISVVLAPGDGVSVVLAPGDGVSVVQLIRVYKLCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6J4</accession>
    <name>A0A8J5N6J4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Slco4a1-L</name>
        <name evidence="12" type="ORF">Hamer_G016482</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6J4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17403">
        <property type="entry name" value="MFS_SLCO4_OATP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF100">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="11">
        <location>
            <begin position="421"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="638"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7174576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="681" mass="73294" checksum="A1AA206948BD9C51" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N833</accession>
    <name>A0A8J5N833_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Zona pellucida-like domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G003322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N833"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF2">
        <property type="entry name" value="DUSKY-LIKE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="132"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7174383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="517" mass="58891" checksum="927EAD74BCCAA3B7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9G9</accession>
    <name>A0A8J5N9G9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Chitin binding Peritrophin-A domain-containing protein 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G001227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9G9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035258402" evidence="1">
        <location>
            <begin position="23"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="66"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="353" mass="39410" checksum="CA2F1D2D69FE671C" modified="2022-05-25" version="1" fragment="single">MGGIHVLRLLLLVLVTAALVRSMDEPHLKPRGRTSKMTRRWRQKTGVGSFKAVRTASGNSLTKPPVLPCTEEGFFPQPGSCHNFYRCVDWMGNKKRFSVFRFNCPYGTVFDDDLDICAGTWRSWNPWNRWNPGSAGTPGCWNPWGGNPGVLEPWRRWNPWSQWNPWYAGTSGSAGTWVQEPLEVLELLAVQELWVLEPLVVLEPWRCRNPWKCWNPGGAGSLEAGTPGFGGTSGLDPLEALEPWYSWNLELDSLGPWNPWWCWNRWNPWVQALECWILSAGTLGAGTPEVLEPWRSWNPGSVEPLVALEPLSGTPSAGTLGVGTPGAAGTLESVEPLESVEPLVALEPWRCRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9J7</accession>
    <name>A0A8J5N9J7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Glutamate receptor-like 68</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Glrk-L68</name>
        <name evidence="14" type="ORF">Hamer_G027609</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003397">
        <property type="protein sequence ID" value="KAG7176465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9J7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035302060" evidence="12">
        <location>
            <begin position="28"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="13">
        <location>
            <begin position="207"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7176465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="641" mass="71233" checksum="DCFAF31ED8FDF6EA" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9T6</accession>
    <name>A0A8J5N9T6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Negative regulator of PDR1-mediated fluconazole resistance JJJ1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">JJJ1-L1</name>
        <name evidence="3" type="ORF">Hamer_G029235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005706">
        <property type="protein sequence ID" value="KAG7175509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9T6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="193"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="379" mass="42777" checksum="6E0AE170BCDA458A" modified="2022-05-25" version="1">MQTSLSFQKLTFLGSLTGSRSSGLHIFSQHLSLLTIFLLSLFPLNTYTRPYRLPPPPADGGAAGGGGRGGSREREEEVGKGRKKSGRGGGNRKGEEEMKLGMRKEEGKKEEEEERKAKFNPEDERRRSVVLLCEDHCQWASTSSPSCVKLVSSRRPHHHPSPPAPPLLTRRPHHYHHPPHPPPIPPPSTHSSAAHTGLPLLPTHPDLKIRQAYLRLARRCHPDKNPNDPKATKTFQELQDAYEVLRNGHFLDRGSSDTTPETQETTPKRMPTFVCRPQVTVNLSINRSSMSYSGPPDSNAKFYSVFQKLFREISFWEMKCKQNTSKLPPPSFGRSSTPLKDVKTFYKYWAEFSTKMYVRPKGKHNWVLISTKPPSETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA19</accession>
    <name>A0A8J5NA19_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative variant ionotropic glutamate receptor-like 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">viGluR-L19</name>
        <name evidence="2" type="ORF">Hamer_G029133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005098">
        <property type="protein sequence ID" value="KAG7175629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA19"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="133" mass="15252" checksum="242CD33BA728756F" modified="2022-05-25" version="1">MINFVEDTFLPSHVLSNRYFHSLCVVFCVVFVLYVCICVSYVMCCVVLCFRLRSLVEFGLYEHWLFSTLRHSRICRFAPSKITVRTSLAFSNLWGMFVLLGAGLQLATLVFCLEVVVGRRKSSPRTHTLSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA99</accession>
    <name>A0A8J5NA99_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004571">
        <property type="protein sequence ID" value="KAG7175932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA99"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="287" mass="33033" checksum="DE0AE523BD79DBE3" modified="2022-05-25" version="1">MSYEEMRRTTFKLLTDTEAATPVHPRLRVSFRTFMEVTPSKVQETKELRQLSRWARGKDPLPHILIIGYTSWMILHMMMMNYTADVLEVMREMHQQVVPLLHQIAQRTRVLVVSQGRYREHSLTGTIYNKASILGDATFDCSEMLFQYYLRQYKDHHLSPATPHVSYTFPTPITGSLKQHSPNPLGPIPNTVRPQTTRTSKDYLDARVTGGGVWWWDTGVPLNLAGISECEELYRRGLVDSSVYTSEHLRCTDDHHVGEDVLSDQITMLLNLMCNSIMQPHTNVCCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAH6</accession>
    <name>A0A8J5NAH6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GMDS-L</name>
        <name evidence="8" type="ORF">Hamer_G009841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAH6"/>
    <dbReference type="OrthoDB" id="10253554at2759"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05260">
        <property type="entry name" value="GDP_MD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000924">
        <property type="entry name" value="GDP-mannose 4,6 dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715:SF1">
        <property type="entry name" value="GDP-MANNOSE 4,6 DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="GDP-MANNOSE 4,6-DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7175819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="356" mass="40423" checksum="DA5DC8EDEF5F54A8" modified="2022-05-25" version="1">MAEESPVKRALLTGITGQDGSYLAELLLSKGYQVHGIIRRSSSFNTGRIRHLYEDAKIHRNGRMTLHYGDLTDSTCLVKIISRVQPDEIYNLGAQSHVKVSFDLAEYTGNVDAMGTLRLLDAIRTCGLDKKVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNYREAYGMYACNGILFNHESPRRGETFVTRKITRSVAKIHLGHLEKFELGNLDSQRDWGHAKDYVEGMWQMLQLDEPEDFVLATGEVHSVKEFVEAAFNEIGQEIYWEGSGVDEIGKEKGTDVVRVTVNPKYYRPAEVEFLQGDPTKAFKKFGWKPTFTFDALVKDMVQADIELMKKDPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAM7</accession>
    <name>A0A8J5NAM7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Tstd3-L3</name>
        <name evidence="2" type="ORF">Hamer_G017021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7176053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAM7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="113" mass="12250" checksum="8CAB51B1C42E896E" modified="2022-05-25" version="1">MSDIDYDELSANLDGLVVLDVRSREEVKKNGQIPGSHCLPDLDEKSFQEKYGFSKPSSDQSLVTHCMMGGRAKRAGDALIAKGLQARVYVGSFNDWNAKGGKVDPGCPFEPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NB66</accession>
    <name>A0A8J5NB66_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G009111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NB66"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055470">
        <property type="entry name" value="DUF7042"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055471">
        <property type="entry name" value="DUF7043"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255:SF1">
        <property type="entry name" value="LD32918P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255">
        <property type="entry name" value="LP06548P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23069">
        <property type="entry name" value="DUF7042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23070">
        <property type="entry name" value="DUF7043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7042" evidence="1">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7043" evidence="2">
        <location>
            <begin position="87"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7176319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="374" mass="42300" checksum="974CE299B5584F66" modified="2022-05-25" version="1">MFSSQYRKCQGIGHSFDATVVFSCLGDWYVGGNHYFTVVNTRESRKEEKYRCFVRNREDDLYMGHSITPECSVLKTPENSPVRFRLSYGDNLAGGSAKTSSYVCLQHRGNRFLMAKLSVEGCQTEHACWELLSRHHNIASGKSLTWPLSSRSFQVCDYSNFRSGREWKYDTLIADTPDPISCPLGGRFSFGQSGPSPLTPRIVGGITSSPLDTYPCHTRVSDMSVCDENRKWIIIDTDLCLSLNKDGHPVDFNSVTDYRLQCIGYWQRTSCPTSSPTTRLILCQGSGAGQWEGRGLRQNFLSSTYEESAAVALNLTLSERLYDQCPMFYDNGKDPWQPRDEMFTIFRFSSHAPSLYVTADVTILLPLVMLISWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBL5</accession>
    <name>A0A8J5NBL5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBL5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="112" mass="12510" checksum="D84E5363227AC0B4" modified="2022-05-25" version="1" fragment="single">MSTQRCITDFIGAESAKGASKKKKKKDKFLIEDRSEEVAAGTTIDSTEKSPKKLKMKKKRAFEEVAMKVEPEDTEQLDSCIITKPKKKKKKKKTKVAGNGNHVSLMVDGYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NC74</accession>
    <name>A0A8J5NC74_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phenoloxidase-activating factor 3-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PPAF3-L7</name>
        <name evidence="4" type="ORF">Hamer_G025321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002814">
        <property type="protein sequence ID" value="KAG7176756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NC74"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7176756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="196" mass="21039" checksum="B817D0C74A3410EB" modified="2022-05-25" version="1" fragment="single">LSVQDTFCGATPISDRYLLTAAFCVFDPDHPPDSPVRSYDIALLKTVEKISFNDVVFPFCVSSERPSVGTTVLGSGFGLVNETHQSPVLQEVEVEVMALAECEKQYQEAGLLPHLKQAYPNLLNGSKVICAGYPGRGACKGDEGGPLYLDDGQGHRYLVGIVSFTGACKKESVTPGIYTSVADHIDFIDSVLYGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCA9</accession>
    <name>A0A8J5NCA9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-directed DNA methylation 3-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RDM3-L2</name>
        <name evidence="1" type="ORF">Hamer_G031417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002646">
        <property type="protein sequence ID" value="KAG7176801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCA9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="115" mass="12750" checksum="E5ED81FEA8F20C60" modified="2022-05-25" version="1">MVSDDLYQGRRRCVMVCYGVLWCTREGGGVLWCTREGGGVLWCTREGGGVLWCAREGGGVLWCTREGGGMLWCTREGGGVLWCTREGGVLWCTREGGGVLWYTREGGKEEEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDF3</accession>
    <name>A0A8J5NDF3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDF3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="125" mass="13093" checksum="49D1527AA61CD969" modified="2022-05-25" version="1">MSTLTNSGGEGMILQNMETANISTLGINNPAFVDVLDDASDPTTPSSTTYTSTNIPQPVVNAPVSGSPPDGENTLKIPTEESKDISRLENDKEEGAHGLRVPVVDGKSNNQDARHTISTQVSLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NJ41</accession>
    <name>A0A8J5NJ41_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NJ41"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF1">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="601" mass="67719" checksum="CD23405C453DA4FD" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T0B7</accession>
    <name>A0A8J5T0B7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium load-activated calcium channel</fullName>
            <shortName evidence="14">CLAC channel</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">tmco1-L1</name>
        <name evidence="17" type="ORF">Hamer_G014736</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Calcium-selective channel required to prevent calcium stores from overfilling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the TMCO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T0B7"/>
    <dbReference type="OrthoDB" id="342726at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008559">
        <property type="entry name" value="TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20917:SF0">
        <property type="entry name" value="CALCIUM LOAD-ACTIVATED CALCIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20917">
        <property type="entry name" value="PNAS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023322">
        <property type="entry name" value="DUF841_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 14" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR023322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7171599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="186" mass="21537" checksum="BFB108CDCF8BE426" modified="2022-05-25" version="1">MWADTLFIVFISICTALFGEGLTWLLVYRTEKYQKLKAEVERQCKRLEKKKEAHGDSIDRQQKRKIEREEERLKNSNRDLSLVKMKSMFAIGFAFTALLSMFNSIFDGRVVAKLPFLPISWLQGLSHRNLLGDDYTDCSFIFLYILCTMSIRQNIQKLLGFAPSRAANKHSTNLFGPQPQQLSGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T2H9</accession>
    <name>A0A8J5T2H9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T2H9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="61" mass="6823" checksum="2EE699948104EC60" modified="2022-05-25" version="1">MTIELFKREVGRDIEEVSRLLICLPLSRNNEGTVSSVLSTPVWKGLLSSQLSTHPLNDKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIA2</accession>
    <name>A0A8J5TIA2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nanos 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Nanos2-L</name>
        <name evidence="11" type="ORF">Hamer_G006802</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the nanos family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIA2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.30">
        <property type="entry name" value="Nanos, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008705">
        <property type="entry name" value="Nanos/Xcar2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038129">
        <property type="entry name" value="Nanos_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024161">
        <property type="entry name" value="Znf_nanos-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12887">
        <property type="entry name" value="NANOS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05741">
        <property type="entry name" value="zf-nanos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51522">
        <property type="entry name" value="ZF_NANOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nanos-type" evidence="10">
        <location>
            <begin position="68"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7172593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="154" mass="17311" checksum="AD4757230B1AD2EA" modified="2022-05-25" version="1">MTRNTKYEKGQGLWGLELPPPPPAWLPAELERLYSSPPLRRHWPVLAPTNSPPTCDRPPACYRNKKALCSFCKKNDEEIEVYCSHSLRDTTGLLTCPVLRCYVCPKCGATGDNAHTLTYCPSQREITDKSSSSKRVSSQLKKTKRNSTSVRNCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJJ5</accession>
    <name>A0A8J5TJJ5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003850">
        <property type="protein sequence ID" value="KAG7176191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJJ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007021">
        <property type="entry name" value="DUF659"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04937">
        <property type="entry name" value="DUF659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF659" evidence="1">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="64" mass="6915" checksum="5D9E00A7B710D315" modified="2022-05-25" version="1">MPNEGIINFVITVPRPIFWSSTATGAESHTGEYMASLLKKMVEEIGAMKVLAICTDNASNTKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKU6</accession>
    <name>A0A8J5TKU6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Artichoke-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atk-L1</name>
        <name evidence="6" type="ORF">Hamer_G008353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001360">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
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        </location>
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            <end position="1310"/>
        </location>
    </feature>
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        <location>
            <begin position="1242"/>
            <end position="1265"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <name type="common">American lobster</name>
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            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="96" mass="10717" checksum="28FC2E0F17F35735" modified="2022-05-25" version="1">MSKALSARLYDIDPSLDRSLKAKRAIENVMLPYIELQREMRSKKAQTTITNFFSRRVPAIAEPADTSQQQDVEAAGTSQQQDAVPAHTPQEDADLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5TN80_HOMAM</name>
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        <submittedName>
            <fullName evidence="6">Epidermal growth factor receptor substrate 15-like 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EPS15L1-L</name>
        <name evidence="6" type="ORF">Hamer_G009748</name>
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    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="3"/>
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        <property type="match status" value="1"/>
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        </location>
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        <location>
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            <end position="576"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1147" mass="124396" checksum="E589811BD88CD904" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TW16</accession>
    <name>A0A8J5TW16_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Kohn A.B."/>
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                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5TW82_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pogo transposable element-like 69</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Pogo-L69</name>
        <name evidence="2" type="ORF">Hamer_G022773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000655">
        <property type="protein sequence ID" value="KAG7178232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TW82"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="100" mass="11056" checksum="A3A585DE2B6B440E" modified="2022-05-25" version="1">MVEGNKTYTKAGNMGAPPLDALCEFVAKSWDAIRVEVITKSFKKCGISNTIDGEDDDMLWRSSDGEDSNNEDKDEASDSESDPYDDLHLSASHELDFEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J7S1</accession>
    <name>A0A8J5J7S1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Expansin-A24-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EXPA24-L</name>
        <name evidence="4" type="ORF">Hamer_G022128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044612">
        <property type="protein sequence ID" value="KAG7154287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6378494at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035243944" evidence="3">
        <location>
            <begin position="25"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1335"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="829"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="869"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7154287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1408" mass="152348" checksum="D86F45195CE47149" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J841</accession>
    <name>A0A8J5J841_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretory carrier-associated membrane protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Scamp1-L2</name>
        <name evidence="3" type="ORF">Hamer_G017570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044465">
        <property type="protein sequence ID" value="KAG7154367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J841"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="130" mass="13562" checksum="65D3B494A70BC4A0" modified="2022-05-25" version="1">MSGFDDNPFADPFAEPSIQQATKGSAPNGLEEYDPFGSQSATNTTTTTAGNNGNPPTYVQPTVGGGVGTGGQPAVVTPTPNNPPAYTPSAQQQVTTAEFQRRQEELEKKAEELARKEEELRNAGSAGGMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J8F7</accession>
    <name>A0A8J5J8F7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DDE superfamily endonuclease domain-containing protein 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G027040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044264">
        <property type="protein sequence ID" value="KAG7154532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J8F7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="142"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="338" mass="38279" checksum="B0C93239349AB2FD" modified="2022-05-25" version="1">MPRRHRITSATDRERIIEAYRAEQDFLVVAAALGVQLTTAYSIVRVYQRENRVEAAHAGGRHKIIDNETLDLIVMLLEANPMMTLREIKEEVMDIFPTKPHFRGAVSLKMSRDSPAERHSPSVKEARHAYATWILATGLQQQLVYIDETGFNLWTKRTYGRARRGERVHCAVGGQRGRNTTVIAAIAEHCGILYHEIHYGSVTKEVFSNFISSLAAIIGDARSILVLDNAPIHNGIAAVYPELNFKFLPPYSPCLNPIENCFSVFKSHLKQYLHREAPRCNAAHARQEGVTLNALRENILQVGVEFALPSVTEHVVSQNYNHVNIYLVQCIERRDIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JAX8</accession>
    <name>A0A8J5JAX8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline-rich protein PRCC-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PRCC-L</name>
        <name evidence="2" type="ORF">Hamer_G024443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041894">
        <property type="protein sequence ID" value="KAG7155357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JAX8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="389" mass="42747" checksum="FDED70876FF01DDF" modified="2022-05-25" version="1" fragment="single">DDSDLGSDSEDGEEHLESSIEKELKPQVTNNGVNGTPFSQVKSNSGQPNLVLDSGVDSIVDEDDNIEVKKTGLLASIPAAKPLTSIGDGVEIGEEADELTDVPTVDTWKFADDEDEDEQQEPERKKLKPSSTGTGLFSLLPEPKHLSVKETKRSLVPHILTKKSVPVQSRPKPKSQPRNTTTVGGNDSDDEGNAGPSDFFSLSESASETVATNKIPAAVASVPEVDPITRKPPVIQTSGECKALPREHTVCSEDYSNTPHYPSVQSQEEVYYPPQDVEMFSGSQTAIDDEAMLRLAGKRRGKGEAINFIDVSADDALLTRDEWMTKALTEEKPCHSFSKKREGLPSQKQKQKHQITYLAHQAKERELELKNSWAQNRMTKMQTQAKYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JG06</accession>
    <name>A0A8J5JG06_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G009481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JG06"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="69" mass="7209" checksum="85E1E13C1FEDC2F9" modified="2022-05-25" version="1">MENSALNEGRVGSSALNEGRNCQKACCKRSDSDKGIVCNCILNLGCGRALEQNGFLGSGKRVLIASSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JH69</accession>
    <name>A0A8J5JH69_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative reverse transcriptase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G030794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035773">
        <property type="protein sequence ID" value="KAG7158082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JH69"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="74" mass="8599" checksum="1ECFFA884B3826DF" modified="2022-05-25" version="1" fragment="single">MIIMRHLYQSKSPVVFDNWKLPGADWMFQVPYRLRDQGSPVDVLYINFSKTFDKDPHARLASKILAYGITGKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHI3</accession>
    <name>A0A8J5JHI3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Neurotrophin 1-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NT1-L9</name>
        <name evidence="7" type="ORF">Hamer_G006093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHI3"/>
    <dbReference type="OrthoDB" id="6359065at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000035">
        <property type="entry name" value="Spz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF12">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035294557" evidence="5">
        <location>
            <begin position="18"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Spaetzle" evidence="6">
        <location>
            <begin position="176"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7156356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="281" mass="31347" checksum="B7223A612138AD3B" modified="2022-05-25" version="1">MALRFVVSLAVVAIVLADQSSHVSISHGGGTPAVSHSSSVPHRAAPSPAPPHGHRPSYTPRPTYPPRPSYTPRPTYPTRPTYTPRPTYAPRPSYHPQPSYHPTPAYGQQPSYDAEPACAAASSKPWCLEDNEYPTYEIEKAAGDHSDKLLTLYADVADLDTKLSVERPNNLYEETYLCPSETAYVRPLRAKNTDGKWRIIVNNIKVHYQTLTQTTRIEECLTSGDACPLVPVCYESKCLQKSIYHRFLVYDPYDQYFPFAIETFKLPASCACLLGAYTIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ17</accession>
    <name>A0A8J5JJ17_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G008744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJ17"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035171499" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11059" checksum="1F0BDE526E07E257" modified="2022-05-25" version="1">MQSAVLCCAALCCTVLYLDTSEQNRCDNEQGGGASSTLNHSQVKLHHDNVRSSRCRRRNPCQRTIVLSWVLSMTIKFNKLSNSTMSSTMSEAMPKKFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJP1</accession>
    <name>A0A8J5JJP1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034735">
        <property type="protein sequence ID" value="KAG7158536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJP1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054148">
        <property type="entry name" value="ASNSD1-SEP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21975">
        <property type="entry name" value="ASNSD1-SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="8298" checksum="6B9D93457A0DFA01" modified="2022-05-25" version="1">MLSGCVIIDVEEEVEERELRVLDYELKSLKADKRVYLQQPNSNIYFLCKKADALTYLEQEREALSVKQKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJS3</accession>
    <name>A0A8J5JJS3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ESCRT-II complex subunit VPS22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">snf8-L</name>
        <name evidence="4" type="ORF">Hamer_G005754</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJS3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000085">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7157338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="156" mass="17471" checksum="698812D3BD8C1FA4" modified="2022-05-25" version="1">MLGVGDFYYELGVQMLELCVATSYRNGGVILLEEVLRRLNQRRRPDNQISSDDVVRAVKKLRVLGSGMEVVATGSSQFIYSIPGELSMDHTTLLQQAETVGHMTVCSAASSLGWTQERVGRTLDHLLRVGIAWRDDQDRPASFWFPAFFQQCTTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JK88</accession>
    <name>A0A8J5JK88_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JK88"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="87" mass="10730" checksum="FCFA5FEB121E6DE5" modified="2022-05-25" version="1">MFNHLFFNFVFLYTKGYILYIEFGPTLLFTVFCEYFSAFQYHILYCNYKFVLKTRIFPILSCVMSQYWSVNQRLRENYQKYTEGKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKA1</accession>
    <name>A0A8J5JKA1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose transporter type 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Glut1-L2</name>
        <name evidence="7" type="ORF">Hamer_G016568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKA1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF128">
        <property type="entry name" value="GLUCOSE TRANSPORTER TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7159180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="197" mass="22273" checksum="75012CBDF4388A45" modified="2022-05-25" version="1">MSYDDVEVLYYSTSLFTAAGLEEWQSKYATLGVGSVMVIMTLVSIPLMDRAGRRTLHLYGLGGMFIFSIFITISLLIKEMMGWMTFISVISTLCFVIFFSVGPGSIPWMITAELFSQGPRPAAMSIAVLVNWLSNFIVGIGFPKMQETFENYTFLPFSVLLACFWVFTYYKVPETKNKTFEEIAALFQRGADRNIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKL5</accession>
    <name>A0A8J5JKL5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033239">
        <property type="protein sequence ID" value="KAG7159375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKL5"/>
    <dbReference type="OrthoDB" id="10508102at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="433" mass="50045" checksum="19DF0C32F737DA01" modified="2022-05-25" version="1">MINMEFEGDQLDDQASDNNITAKTHKGPCPLEQENKKIFKLFKILGVILIRWDKHKKEYVLLKVRFFISYTFWFFWPLLGLCVALVMKRIFKTSGGADHINDAIESSLFVLGFAVVPAIKTYSLSLINTCLLGIMKKTVSLKEIKDKFEKRNDDEYLPSDTDKEAFQDNSKLRRALPIMSVILSTISFLGVWIYDMIQVVEWDELKREWPFFFMQFNYLTLPCITTLFSVIFIDWLRKLYKIMREKLEELVRGQKTTVDVQVIQDIGDYVKKLQDIFSRLSSGFLTYVLGFNFLVSVVGGIFCTAKVLQGFPNIIYLVPLTIAVFHIGLICHKSQELMDEHERIILLLKQLFRKSRKNPKPLPYDELHILLENLLEKMLESPPQVATFGNYKVGNGLLLATLGFIISYAMLANDVLQLQDQVSSLHCNFTLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKR0</accession>
    <name>A0A8J5JKR0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CCA tRNA nucleotidyltransferase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Trnt1-L</name>
        <name evidence="9" type="ORF">Hamer_G016641</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKR0"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050264">
        <property type="entry name" value="Bact_CCA-adding_enz_type3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173:SF1">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="7">
        <location>
            <begin position="59"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="8">
        <location>
            <begin position="216"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7159241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="442" mass="50806" checksum="FEC07E7995D73AEF" modified="2022-05-25" version="1">MLAAAPRLSTFLPRNSLFWQTLCYHLHTMKIEESRMAAVLRPGVKKLAGMFSEHGYEVRIAGGAVRDLLLGKVPHDLDFATTATPEQMKSIFETEGVRMINAGGEKHGTVTVRLEDENYECTTLRIDLVTDGRHATVQFTQDWELDANRRDLTINAMFLGLDGTVYDYFNGSKHLQDRFVTFVGDADKRIKEDYLRILRYFRFYGRIAEGPDNHSPEVLESIKKNVEGLGKISGERIWVELQKIITGNYGGDLLIKMVECGLNPYIGFPENLDCDNVRCVYKRCEEANIQVKEMHHMTLLASGLSSEEECIKLIARIKCSKREQEILLHIIKYRDFAMQATSLKEIKDLLVDLVIGEKRNKDVALFYVSEILKYTCRIEYRNALQDWNLPRFPVNGNMIGEKGIPRKKTKFVLNDLLEEWKKSDFSLSAKDLLDTLDIERYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKR8</accession>
    <name>A0A8J5JKR8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Tim22-L</name>
        <name evidence="10" type="ORF">Hamer_G004078</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKR8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7159450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="197" mass="21052" checksum="D3187C5AB8B9789B" modified="2022-05-25" version="1">MEAVMAAEANTDGGVSDGGRRIPLFTPQEIDQIAKFLVGNQRRERENMIIPRSFTPTVIKSKEEKTVEATFESCPFKAVLSLLAGFVLGGGIGLFAASVTPSIPTPDKPQQSAREVLRELKVSTLSYGKNFAAIGFMFSGVECAIESYRGKTDWKNGTYAGGVTGGILGLRAGMKAGVVGALGFAAFSSIIDYYMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JL06</accession>
    <name>A0A8J5JL06_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Hamer_G021655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010031456">
        <property type="protein sequence ID" value="KAG7160277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JL06"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="7">
        <location>
            <begin position="42"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="8">
        <location>
            <begin position="283"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7160277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="353" mass="39000" checksum="F0A1121250C0C36A" modified="2022-05-25" version="1">MAVKLGFNWSSWLLIETRLDKYWADQDVIGDSLKNLTLGNMKALILVGGYGTRLRPLTLSRPKPLVEFANKPIVLHQIEALVAAGVTQVVLAVSYHAEQMEQELAQEAQRLGIQITFSLEEEPLGTAGPIKLAQSILAANDEPFFVLNSDVICDFPFTQMVKFHKQHGREGTIVVTKVEEPSKYGVVVYEEGGKIDSFVEKPQEFVSNKINAGMYIFNPSCRPMSIEKEVFPFMARDSQLFAQELHGFWMDIGQPKDFLTGMCLYLNSCKISNSAKLYKGPGVVGNVLVDSSAKIGKNCRIGPNVTIGPDVVIEDGACIKRCTILRGATIKSHTCVITTHGSTEHDSQYRTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLA5</accession>
    <name>A0A8J5JLA5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035774">
        <property type="protein sequence ID" value="KAG7158081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLA5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="109" mass="12621" checksum="4CB44CAD095D5BBF" modified="2022-05-25" version="1">MHILFLPSTNTTSHPHTQKVGWMGRELGWIVRLRGERVAGRELLQTGLFVWLTGPTTRCFLEVIKVKHFHSAIGVQCPDCQHLVSKILTVLYFHLLYIYNTFKLIVCMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMC2</accession>
    <name>A0A8J5JMC2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BMP-binding endothelial regulator protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BMPER-L</name>
        <name evidence="9" type="ORF">Hamer_G024447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine protease inhibitor-like (TIL domain-containing) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038115">
        <property type="protein sequence ID" value="KAG7157093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMC2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000055">
        <property type="entry name" value="alpha-tectorin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052424">
        <property type="entry name" value="Kielin_Chordin-BMP_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698">
        <property type="entry name" value="CROSSVEINLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698:SF4">
        <property type="entry name" value="CROSSVEINLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="VWFC" evidence="7">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="7">
        <location>
            <begin position="74"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="7">
        <location>
            <begin position="140"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="8">
        <location>
            <begin position="206"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7157093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="541" mass="60405" checksum="2E4AEA31EF6AC179" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMM4</accession>
    <name>A0A8J5JMM4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMM4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="106" mass="12446" checksum="96BF642582D35333" modified="2022-05-25" version="1">MYVRFWHEAPMAVRAPFNDLQLMKVLKEYPHEKVAHAAQAAISRHLWYLSEHLIGLSLFDDRIDTETKKNMVQNFQCPKKQDFSRRIVLSDETPISNVASFVTERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNI2</accession>
    <name>A0A8J5JNI2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-serine deaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-threonine dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tdcB-L</name>
        <name evidence="7" type="ORF">Hamer_G011499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNI2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF6">
        <property type="entry name" value="L-THREONINE DEHYDRATASE CATABOLIC TDCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="6">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7158815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="107" mass="11674" checksum="737C198EF9BC6441" modified="2022-05-25" version="1">MTQRNLTLEGVSVLVKEATLRICSYVHHTPLLATPTLSEETSASIFLKLENEQVTGSFKVRGAFNKIGVLADKGVTKVYTASTGNHGLACVSKLFFIVQLQYCINIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPH8</accession>
    <name>A0A8J5JPH8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPRY domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SPRYD3-L</name>
        <name evidence="3" type="ORF">Hamer_G022107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031890">
        <property type="protein sequence ID" value="KAG7159881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPH8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12908">
        <property type="entry name" value="SPRYD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035783">
        <property type="entry name" value="SPRYD3_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPRY" evidence="2">
        <location>
            <begin position="87"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="SPRY" evidence="2">
        <location>
            <begin position="233"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="449" mass="50281" checksum="A07C7F1F0F0389DC" modified="2022-05-25" version="1" fragment="single">VEGAPAQMARRLTHPLLRSHSPLRCLATLEASSNKLNRSEKKRRAGYRRQRAGVRRPGSSQTNAELYSEEEEEERVGVYVGEVPVCADHSYFEIEILDMGVQGSISLGLCSAKYPLHKLPGWAVDSVGYHADDGRLYKARPRGVVFGPRCGAGDRMGCGVKYDQLSLERDAVRLSPQLLWPPDEDTHMSVDSMEEEWLRLHDVRLNGQMLEYCGRGKSLVDVGLAQARAPLNTTSHYFEMEIVDPGRLSHITIGLTKKDYPKDSHPGWNRGSIAYHADDGRVFTGSSMGSIFGPRCHKGDVMGCGIIFPRDYVCNYDSEGGSMEEESPEPLECDDLLEHLLQYQQPAPPPPLSPHYPHRHRLHHTHILPTDSDEDDDEEEEEEEEEEEDDSLQPSHQHPVGGKVQVFFTRNGQMIGRREVALPKGGFFPSVSMGSINERVRVDLHPLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPU3</accession>
    <name>A0A8J5JPU3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034340">
        <property type="protein sequence ID" value="KAG7158834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPU3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035206325" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20412" checksum="EA4EF2642999EF54" modified="2022-05-25" version="1">MWIVRWLTAMVVVTVSVEARPQLVDVASMAASGDFGGAEIAGKARSFVSNLAADTVGSVRVLGEGTRDVIKDMWNNSKQTMQRFTAVATDTVDQNVQGVRDAIRTTNTFVADGAQEARRLAEGAAQSTLGVIRDAVNSNGQFLEGVRKMVLQGVVETGQATGDFVQQAVTNAKDFVEAGTGVVSRVVTQRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQF4</accession>
    <name>A0A8J5JQF4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQF4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="103" mass="11397" checksum="E7EB6FEEF86FB83B" modified="2022-05-25" version="1">MLPPPPIVWRPTTTCYLHNTSSVAANNMLPLQHQHCGRTCYLHNNSSVAAKNHVLPPQYQQCDGQQPRVPSTIPVVSRSTTTCYLHNTSSVAGNNHLLPPPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQJ0</accession>
    <name>A0A8J5JQJ0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 22 member 6-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Slc22a6-L3</name>
        <name evidence="7" type="ORF">Hamer_G026699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033662">
        <property type="protein sequence ID" value="KAG7159284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQJ0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7159284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="130" mass="14811" checksum="219C43419D808910" modified="2022-05-25" version="1" fragment="single">LLRRDSCTYTVDRSSLAGLEEKHCTEWDFDTSVFTRTLTSEFGLVCQNAYLRASYQSIYMFSTIFSLFISGYIADRYGRKIVVVVSLVMFSFISLGTSVITNFSVILAFRFIMGTLANPTTYMLCEYLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQZ3</accession>
    <name>A0A8J5JQZ3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027216">
        <property type="protein sequence ID" value="KAG7162722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQZ3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="507" mass="57687" checksum="83A3CB9DA70CCA47" modified="2022-05-25" version="1" fragment="single">GLWDQSVLPARALWDQSVLPATRVCYLVGPRVCCLPEVVGPECVTYQGCGTRVEPECLPEVLECVACQRVVGPELWDQSYLPGVRDQSVLPTRRVRAQSVLPARGLWDQSVLPARGLWDQSVLPARGLWDQSVLPARGLWDQSVLPARGLWDQSVLPARGHFTLMLHVTINLHVTINLRVNINQHVTINQHITINQHFTLMLHVTINLHVTINLRVNINQHVTINQRVTKHSNRRNYTDKELINDMIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDSSSDEQEATSDDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRA2</accession>
    <name>A0A8J5JRA2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sialin-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Slc17A5-L6</name>
        <name evidence="7" type="ORF">Hamer_G021311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031136">
        <property type="protein sequence ID" value="KAG7160653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRA2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="75"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7160653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="234" mass="25743" checksum="5DE91FD29595AD61" modified="2022-05-25" version="1" fragment="single">LIYRCPSLIYRCLSLIYRCPSLIYRCLSLIYRCLSLIYRCLSLIYRCLNLTRMAKTRRRECFTLPARVSLALLTSAGVVALYLVRVNFSVAIVAMVRTASPNTNYTTTTAPHTAFCSTLNQVNRSVSGEEAVDVKLESSGNSSQTNNTAQDFSDTMVLTGTERGLVLGGFFYGYCLTCILGGRLGELYGTKRVFGGAILIGGVLTLFTPLAARSHYVVLMLLRTVIGLSQVRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JS88</accession>
    <name>A0A8J5JS88_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Filamin-A-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cher-L1</name>
        <name evidence="5" type="ORF">Hamer_G008881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JS88"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="122"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7158244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="220" mass="24045" checksum="17B2F822551D98ED" modified="2022-05-25" version="1">MDPITARLMQEPEKVPNEHNTYSLYNSNESLTLSSDSAPLPSDGEGKGKYLESGSKTTAARTSRAYPDAMPVKDFAMVDEARVEFSEEEEEEEGEGEETEGDGEEGEEAKDGDKDEGESRRSEDRRPCGCRAYGEGLQRGTVAGLNTFFIDTVEADQGEVTVSVEGPYERSVSGTEVYPLEEAPGVYQVQFQVTASAHYHVVITWAGQHLPGSPFTCIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSN9</accession>
    <name>A0A8J5JSN9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031336">
        <property type="protein sequence ID" value="KAG7160303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSN9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="95" mass="10262" checksum="8590D100B11994ED" modified="2022-05-25" version="1">MLVVEERVDTGYGDVKLCNVLFEGRIGVVSGSDGGRASGYSATEMGAKGGASGVGYVPRGKSKEGDDQVLCIYLGGYEEDVLRRKEEARRRRSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSX1</accession>
    <name>A0A8J5JSX1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Transposable element Tc1 transposase-like 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tc1a-L22</name>
        <name evidence="2" type="ORF">Hamer_G001687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSX1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="159" mass="18185" checksum="9196E9EA070FF197" modified="2022-05-25" version="1" fragment="single">MNTTQQRIPTGGQIIVLREGLMVRAIAARLAVSTSTVKRWIRRYVETVMAQEIPPKILCLFSERNRRPRLTIRDENAAIIATIQNNSFSNAVAIREALHLNVCAQTAGIQHRVPAVKERLTGRLQFVQQHMGEELEFWSRVVFRDEKNFASTNYGKIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTE2</accession>
    <name>A0A8J5JTE2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamate receptor ionotropic, kainate 2-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Grik2-L6</name>
        <name evidence="11" type="ORF">Hamer_G007369</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTE2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7161733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="273" mass="30637" checksum="E3421476518E3BCE" modified="2022-05-25" version="1">MQQGQEVVPERYPARLVFGSMWVASVVLYASYTSNLVSYFTVNKSTLPINNLEELVKSDYKFGTRAGSVYGDNMKASKSEVYKAASAKLESFGKEVTMGTYEEAIQRTLQEPYAFIGDYVVLDYYQMKDCNLVLLKQQLFQTMSSFVLPRHSPILPAVNYYMSLMDESGILEKLRQRWWRGQPCEDIGTVTAYQSLGLWEVCSAGLLMLVGVVMAVLVCCLEHAGPRLHHTSLITRTTTSNRNRSISSECIPSSQRCSTNTTHGQVLKTVLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTS4</accession>
    <name>A0A8J5JTS4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate receptor U1-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">kbp-L6</name>
        <name evidence="16" type="ORF">Hamer_G007825</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTS4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="94"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7162311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="375" mass="42930" checksum="A0738CA61BCEDC4F" modified="2022-05-25" version="1">MLHTFANNLNFTYVLREPLDEKWGTPADDGNWTGIVGDLQHQQADFSLDLTLTESRSRVMDHSRIYNYDPYVILSLKPSSLPRHLALTRPFKGEVWIAIIVCTPVMGLILWLLQKAWSWALSERDVSLVTPLFHTWGILLSEPSPTLPTKASGRVLMGWWLLTCVIITAAYHSSLIAHLSVQSKYPPINTFQDLLNRDGWSWGIYDLTGTNFLYFNGSSDPDIQEIYQHMQNMENSDAEEWLERVLHGGFSLLDLKTWIQIQVAKRYTDKDGNTPFHISTTEYPVFGGNISKMKQRLIEAGLLSLWLDELLKNEFKQNNTEEEGKEQPLYTEHESGQVVLTLDHLQGAFYLSLLGCCLAFGAFLIEILIHNYYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTY8</accession>
    <name>A0A8J5JTY8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative variant ionotropic glutamate receptor-like 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">viGluR-L25</name>
        <name evidence="9" type="ORF">Hamer_G007929</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTY8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7162401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="221" mass="25385" checksum="FC249AAD6CD8874A" modified="2022-05-25" version="1" fragment="single">FRSSLIAHLTVPGKSQTLDTLQDLADADGWRWGTEPWQVSGAIREYYSKNTELVMTQIMDEMEWYSIDVLLEKVLQGGFSFICSQKRFAVYVASWYANSKGETPFYVSNKAFSLMLCFGWSFRKGAPFYRKIALMTSWMQDAGIIDYWTEEVMARRVRENRETAALNLVKDTPQDDETQVILGMGHLQGAFYLLILGTVVAFLGLLWENYAQSCYPLHLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVN4</accession>
    <name>A0A8J5JVN4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein assembly factor 5, axonemal-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Dnaaf5-L</name>
        <name evidence="3" type="ORF">Hamer_G002154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVN4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052623">
        <property type="entry name" value="DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056497">
        <property type="entry name" value="HEAT_DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057978">
        <property type="entry name" value="TPR_DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 5, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24573">
        <property type="entry name" value="HEAT_DAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25757">
        <property type="entry name" value="TPR_DNAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein axonemal assembly factor 5 TPR repeats" evidence="2">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein axonemal assembly factor 5 HEAT-repeat" evidence="1">
        <location>
            <begin position="297"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7163083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="742" mass="83333" checksum="3FC200AFCA67190B" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW89</accession>
    <name>A0A8J5JW89_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcium and integrin-binding protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CIB1-L</name>
        <name evidence="6" type="ORF">Hamer_G001704</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW89"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000035">
        <property type="entry name" value="Calcium and integrin-binding family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051433">
        <property type="entry name" value="CIBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791:SF1">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0401">Integrin</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7160449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="196" mass="22600" checksum="522CF94F1A537EA7" modified="2022-05-25" version="1" fragment="single">ELTYFTKKEILYAHKRFKNLALEKVGHNRNAKLPMDKLLTLPELRANPFGERMCLIFSSTKNIGYKRFYIGVLYRSSSTGTVYVDKFLCTYSNEFQDGDCTFEDFLDMMSVFSETAPKSVKAEYAFRIFDFDGDDYLGRGDLEETITKLVSPQRFSDRDMEALVSRVLEEADLDDDGMLAFAEFEHVISKSPDFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXZ2</accession>
    <name>A0A8J5JXZ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXZ2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="383" mass="43067" checksum="7A3C4E14E3F3A000" modified="2022-05-25" version="1">MTPVHPKQYLVHPFTHPMTPVHPKQYLVNPFTHPMTPVHPKQYLVNPFTHPMTPVHPKQYLVNPFTHPMTPVHPKQYLVNPFNPKQYLVNPMTSHPMTPVHPKQYLVNPFTHPMTPVHPKQYLVNPFTHPMTPVHPKQYLVNPFTHPMTPVHPKQYLVVKHSQVVREHLQVVKHSQVVREHMQVVEHLQLVKGHLQAEREHLQAEREHLQVVREHLQVVREHLRIIHQEQCNTRTSGEPQYSLRRTSELQQNQQNFKRNSEQLQVVLLAVVAVASAQTNHPTGGSGAGLAGAGGPGGAGAGAGAGAGAAAGFKSPYGPKVYGFGLNNPWAFPHNPQLVRYAERLAAQQPGVLVRVNADGEIDFTNQYGMEVDLVSPFGMELEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZE6</accession>
    <name>A0A8J5JZE6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Usp8-L4</name>
        <name evidence="6" type="ORF">Hamer_G010483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZE6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="5">
        <location>
            <begin position="425"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7166812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="707" mass="80611" checksum="88A8446FC59C5A78" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZP6</accession>
    <name>A0A8J5JZP6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZP6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="190" mass="21478" checksum="A58491D9EAE5D249" modified="2022-05-25" version="1">MNQVLETVRSPPAPGFQEVTREDLEEPMQDGNTFDVEDLLEDEGGGESGDAVSDAEETEQRKVTTQKLSLLLGVCTSLQEMIQDIESESGEREQVIGVLESTSRKYQKQYNERVNARQQSLITRFLSQCRPAKEDQQREVEVDENIDDIGEMPEDFDFAGFHEVLAEVGEPGARGQHAHFVHLIWQVLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0V9</accession>
    <name>A0A8J5K0V9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ectopic P granules protein 5-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Epg5-L4</name>
        <name evidence="1" type="ORF">Hamer_G030383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025422">
        <property type="protein sequence ID" value="KAG7164518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0V9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051436">
        <property type="entry name" value="Autophagy-related_EPG5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139:SF4">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="242" mass="27435" checksum="2728CC7F57D94AB2" modified="2022-05-25" version="1" fragment="single">HLFILNHVLRCPPGVGTWAPSYIQIGGPWEQDGIDGGVCGGMLGCWPLDHALTVLSTILNPVKAREDFLHHLKETALPSQVDEDKNLSEDKNDNVWVVVDSSGEEEEDPAQLWARFNENDVVQILNQVPFKEIFQHILLIKEEDGSLNYDVSCTSHQGFMKLFAFATHLLQLFRTGLATYSQVRYRGATKRICRLLRHTVEYITDHWQSFLSLHQYSLSHSTAMSQAVAHLESLQVSYCVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K138</accession>
    <name>A0A8J5K138_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">malate synthase</fullName>
            <ecNumber evidence="1">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mls-L</name>
        <name evidence="10" type="ORF">Hamer_G011115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
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        <reaction evidence="5">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="1"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K138"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:tricarboxylic acid cycle"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
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        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="122"/>
        </location>
    </feature>
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            <begin position="212"/>
            <end position="452"/>
        </location>
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            <end position="572"/>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7166286.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Greenwood S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Kohn A.B."/>
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                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
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                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="EMBL" id="KAG7170432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A8J5K5Z4_HOMAM</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
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                <person name="Greenwood S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        </location>
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        </location>
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            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="154" mass="15888" checksum="E8E7AAC00E77419B" modified="2022-05-25" version="1">MVRLHVALTLLVLLTVEAAAHNPFRRRHNTRYSPRRRPSVGGATVYWRGGVRRRPAAVRVNDGDGNVGHGTPIDVDNVGGVGIVGQENPADAANVGGVGIVGQENPDDAANVGGVGIVGQENPDDAANVGGVGIVGQENPDDAANPRQTVGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K692</accession>
    <name>A0A8J5K692_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Sulfoquinovosidase-like</fullName>
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    <gene>
        <name evidence="16" type="primary">yihQ-L</name>
        <name evidence="16" type="ORF">Hamer_G016099</name>
    </gene>
    <organism evidence="16 17">
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        <name type="common">American lobster</name>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014436">
        <property type="protein sequence ID" value="KAG7170296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06594">
        <property type="entry name" value="GH31_glucosidase_YihQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052990">
        <property type="entry name" value="Sulfoquinovosidase_GH31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044112">
        <property type="entry name" value="YihQ_TIM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46959">
        <property type="entry name" value="SULFOQUINOVOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46959:SF2">
        <property type="entry name" value="SULFOQUINOVOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="15">
        <location>
            <begin position="2"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="500"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7170296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1408" mass="158697" checksum="FA7E0E2D1BF47B5F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6W8</accession>
    <name>A0A8J5K6W8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Gfpt2-L</name>
        <name evidence="4" type="ORF">Hamer_G010114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6W8"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="135"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="306"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7167728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="457" mass="51134" checksum="8ABFBA241FD62FCC" modified="2022-05-25" version="1" fragment="single">HRSHVFDLPNVLARTESTAEFLPLGDDKEVEYFFASDASAIIEHTNRVIYLLDDDVASVDKEGILKIHRLKRSLEDSHAREITTLKMEIQQIMKGNFSSFMQKEIFEQPESVVNTMRGRINFDSETVVLGGIKEHLSEIRRCRRLLLIACGTSYHSTIATRQLLEELTELPVMVDMASDFLDRNTPIFRDDVCFFVSQSGETADTLLALRYCKQRGALIVGITNTVGSSICRESHCGVHINAGPEIGVASTKAYTSQMISLVMFALMISEDRISAQPRRSEIIQGLRKLPEQIKEVLALDSKIQEISKEVFEKMSLLVLGRGYNYATCLEGALKIKEITYMHSEGIMAGELKHGPLALVDKGMPIIMICTRDNVFVKCMNALQQVTAREGRPIVISNKGDQELEKFASNILEVPRTVDCLQGLLTVIPLQLISYHIAVLRGCNVDCPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KCG8</accession>
    <name>A0A8J5KCG8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Hamer_G010092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KCG8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000370">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF116">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG5065-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="6">
        <location>
            <begin position="15"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="5">
        <location>
            <begin position="357"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7167709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="462" mass="51779" checksum="BE888231DAD3FC4A" modified="2022-05-25" version="1">MSAVADFYRDRSVLITGATGFMGKVLVEKLLRSCPGLVSIYLLMRPKGGHDVKVRLEELLNSKLFDELRSTSPEVLRKLKPVEGDIMLPGLGISVDNAAALTSTVSVVFHAAATVKFDEALKLSLQMNVLGTKRLVELCHKMTKLVAVIHVSTAYCNCDRGEVKEMVYPPPIDPYKLIQLVDWMDDETFNHLTPKLIGSRPNTYTYTKALAEHVLVQEAGSLPLAIVRPSIVAAAWREPLPGWVDNLNGPTGLIIGAGKGMLRTLHCRGELVADLIPVDIPINLLIVTAWHTATRRQSELTVYNCVSGMERPVRWGEINEHGMAALRRNAMNDVVWYPNLRFTQHKTLNTIAVLVQHWLPAYLMDAASKLAGKRPIMVRIAQKLDRAAACLEYFTTHEWCFCNDNVQHLWSTLSEADQHTFNFALSALHWPTYMEQYCLGTKRYVMKEELATLPSARKHLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KGC3</accession>
    <name>A0A8J5KGC3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock 70 kDa protein cognate 4-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Hsc70-4-L2</name>
        <name evidence="7" type="ORF">Hamer_G018547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012106">
        <property type="protein sequence ID" value="KAG7171434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KGC3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000135">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000003">
        <property type="entry name" value="heat shock cognate 71 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000056">
        <property type="entry name" value="Protein CBG18239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="589"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7171434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="625" mass="68762" checksum="5B576FA8B80C41F8" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KHN6</accession>
    <name>A0A8J5KHN6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018394">
        <property type="protein sequence ID" value="KAG7169119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KHN6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="203" mass="23562" checksum="7B8F12666510616C" modified="2022-05-25" version="1">MYVRFWHEAPMAVRAPFNDLQLMKVLKEYPHAKVAHAAQAAISRHLWYLSEHLIGLSLFDDRIDTETKKNMVQNFQCPKKQDFSRRIVLSDETPISNVASFVTERTLDIFDVLTLDGKERAQLFLSKDLKTWKDDEVFITMRDRAINMKVVNDSAERAIALIERYNESITQNEDQKQYLLQAVAAHRKKLPTASKAAMMKGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KNN2</accession>
    <name>A0A8J5KNN2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized crustin 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G013518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KNN2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="221" mass="22851" checksum="25C59CEA8A1FA7A5" modified="2022-05-25" version="1">MPRRWSCSAALYAPPVVELTCPVAGGRVHLPCMPRRWSCSPTLYAPPWSCSPALYAPPPIMITCPVCPTGGVVLTCPVCPAGALYACCSPALYAPPVVVLTCPMRSLWLLVVVVALVAGDKDSDAGNNNAAQKVDSGSDTAGQTRSSTGNSGARSGPGDARILGLNNVIGIGQALLVCTHNRSLGPPSPCKSDFVCSGADKCCFDKCLQEKVCKAPSGFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KR74</accession>
    <name>A0A8J5KR74_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Isobutyryl-CoA dehydrogenase-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Acad8-L1</name>
        <name evidence="8" type="ORF">Hamer_G024654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012319">
        <property type="protein sequence ID" value="KAG7171384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KR74"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052547">
        <property type="entry name" value="Mito_Isobutyryl-CoADH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43831">
        <property type="entry name" value="ISOBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43831:SF1">
        <property type="entry name" value="ISOBUTYRYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="70"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7171384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="222" mass="24901" checksum="544D63101213FAA1" modified="2022-05-25" version="1">MPTGRIAASGRKKDPLWYYFDRIPKGKGFRAKWLSFGKKEKKVGWNSQPTRMVIFEDCRVPASNIIGKEGQGFSIAMKGLNGGRINIASCSLGAAHASIQNAADHTKVRKQFGKPLSSFQNSQFRLAEMSTELVASRLLVRNAARALQEDHPDAVTLCSMAKYYATEKCFNIINEALQLHGGYGYLKDYSVQQYLRDTRVHMILEGTNEVMRILIARHVLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MIF5</accession>
    <name>A0A8J5MIF5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019013</name>
        <name evidence="1" type="ORF">Hamer_G019514</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046868">
        <property type="protein sequence ID" value="KAG7153458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010021370">
        <property type="protein sequence ID" value="KAG7167624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MIF5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="166" mass="18946" checksum="401E61E153E8CAD1" modified="2022-05-25" version="1">MAEDLYKKAKAICETNYIQEQGGPRCKQKMEEYVVESSCGTSSNLNNVELLKKNLYFPCLDRMINELDQRFTGVRADLMKGIQACHPASATFLSEEFLIKVTVHYKIQLKIQEIRVVKKFLARKKETGATPDVLSAYRYLDSDMFPTLKAIFQVAMTIPVRSCSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJY0</accession>
    <name>A0A8J5MJY0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045000">
        <property type="protein sequence ID" value="KAG7154189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJY0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="136" mass="14389" checksum="CBF6C0BF9680D49B" modified="2022-05-25" version="1">MTSLKCRCYATNMLTTTKVNSLVSLKKTHSTNHDTKISVTSKLGSSTLNTSKREARAPQAANKRRDNSVSPDAGKSAPGSTSTVTSSVVAALAERGGVRGRRGKEAGFNNSTSANRADHLQTVHQSHGVDDARHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK47</accession>
    <name>A0A8J5MK47_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G020486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045000">
        <property type="protein sequence ID" value="KAG7154177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MK47"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035215027" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="93" mass="10581" checksum="795918A6F0873392" modified="2022-05-25" version="1">MKTCGVALLVVVLAIMVSAEEESNKSYWLGGTDFFEEDNWFWLNKKKVLTGAPFWEPGQPDGGLKENNLIINHHGHLEDRDPSELHPFICQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKG4</accession>
    <name>A0A8J5MKG4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tigger transposable element-derived protein 1-like 179</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TIGD1-L179</name>
        <name evidence="2" type="ORF">Hamer_G031001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043832">
        <property type="protein sequence ID" value="KAG7154823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKG4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="155" mass="18026" checksum="24DF981140318671" modified="2022-05-25" version="1" fragment="single">WKEVTVRCLCAAWRPLWPECVLQRDFEGFEELEEEAVVHEIVSLGNSMGLEVDDDDVEELVEEHSKELSTEELLELHKEENETLKRSLTSEESGEEEDKEESRIIPAKDLEDAFFCWSKLSKLAEDYHPDVGSVQKAISVFNDNVMNYFWKVQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLK8</accession>
    <name>A0A8J5MLK8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eIF-2-alpha kinase activator GCN1-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Gcn1-L3</name>
        <name evidence="1" type="ORF">Hamer_G023874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040803">
        <property type="protein sequence ID" value="KAG7155720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLK8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="59" mass="6758" checksum="F6CC9065BA581988" modified="2022-05-25" version="1">MVWTGKESDMNAVDWGWKLEDNQFVPVMTKKTAVPESLLQMVHCNCTTACRTRCSCRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPY0</accession>
    <name>A0A8J5MPY0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033261">
        <property type="protein sequence ID" value="KAG7159365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPY0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="251" mass="28851" checksum="E41EFFFC31AF4567" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPKNVNATKLSELVDLSLEVLEPPLTTSLTSKELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR12</accession>
    <name>A0A8J5MR12_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4 gamma 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Eif4g1-L2</name>
        <name evidence="5" type="ORF">Hamer_G012721</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR12"/>
    <dbReference type="OrthoDB" id="6631006at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="38"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7160177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="262" mass="29554" checksum="0A7044A030658B3F" modified="2022-05-25" version="1">MPEGPHVDMNGGSSGQPPLRRCDNPWKPNAQHGQSEVYRRMLGILNRVTQQSLGIFLEQARELPLSDPTHLPHILSLLLEKSQDEPMFAPIYARLCRDLAANAGIQRDLTAACESHFMDNYQQILHYSVIFEGPITSQLIQEEILARKRFIGHLKFMSELHKVGVVSGNQLAAMAETFLQHGDDRSFEGLCRLLSFSALGLIRSHEELVNRSCTYLENCLANGSLNPRLRFLTQDTLDLRANGWRPRDGDRIHPPPGRNVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR91</accession>
    <name>A0A8J5MR91_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031125">
        <property type="protein sequence ID" value="KAG7160656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR91"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="43836" checksum="3726394CAC62A377" modified="2022-05-25" version="1">MFGDSVDVGLREDHGEASQVNVAESRSVNDELRLLESQLKLKEAIERRVGIRQAEAEAKAKEAEAIAKEVQRTFNPSLHRARQGNTNTSNFVRDRRSWTRSPPNGASKFSTYPCSYCGKPGHKAEFCWTRLQLNTGKPAMIITKETNTSPVGVMAGLSKADSMPIGLISTKTEARESAVSVLASRDFDLFQESFAKDPDVGTFRPFLSQGTVEVDGVETPVTILRDSGCLQTLIKEGVVAARKTDKYFVFRSLWGQGVAPLVLVRVTSSCFSGTANVACLHELPVAGVDLILGNDLAGGQMGNVIPPSVLRERPESTAELQQLEDDMPGVFALCAVTRSMSMTNDHNVTPVVGDSLSLGLFANPIASQDISFAVNAVTGKVALIAAQEQDDSLRLLFDRVSELCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSD2</accession>
    <name>A0A8J5MSD2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inactive dipeptidyl peptidase 10-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Dpp10-L1</name>
        <name evidence="6" type="ORF">Hamer_G007392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSD2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035174508" evidence="4">
        <location>
            <begin position="17"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="5">
        <location>
            <begin position="76"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="5">
        <location>
            <begin position="151"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7161752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="421" mass="47255" checksum="8833B3326DDE5C64" modified="2022-05-25" version="1">MLVVAAGIATIILTRGSSSLAPATSALTATPGGIALGEVLNGTFSTDSFNGTWISEFFNRNFKAPSGWRVFKYVFSPSRKYLLIIHDVQKLFRYSYLARHTILNLETGETVPLAPTRVRTRSEQPPLLFATWAPTDDALAFVSHNDLYYTTEEILSSNSALWFNPDGRRLAFATFNDSRVDTMNFPLYGRPGDLSFQYPIQQSIKYPKPGRANPVVDLWVVDLGKLVSGSGETVTRLPPPTSLASVDHYFTTVGWATPDKVSVMWMNRHQNVNIISLCSVDGVCKDDLVHESPDHAWNDLYTTPKFDEVNGDTYLIILPTNQGEKGNFKHINLRRSSDKTLIPLTTGTYEVVEILSWDQKNHLIYFTAAPAGKPGQRHIYYVRERLLDRSLPLEKRLEIDVEGGFKAQVSMKMPPDYNPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSI1</accession>
    <name>A0A8J5MSI1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G007391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSI1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="65" mass="7596" checksum="0AF7A58DD86F0C6E" modified="2022-05-25" version="1" fragment="single">VTLWAYEKLDSIRTISHKLGISATTEIKWIRRWNEWGNLNDLERHPRPRVTTPEEDARSAAGHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU67</accession>
    <name>A0A8J5MU67_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adipocyte plasma membrane-associated protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Apmap-L2</name>
        <name evidence="2" type="ORF">Hamer_G004613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU67"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF88">
        <property type="entry name" value="ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN HEMOMUCIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="304" mass="34439" checksum="6C046B6FB1B12212" modified="2022-05-25" version="1">MRYWLKGTKAGQTEVFVDRLPGIPDNIRDKEDGGYYVSLVIVPTDSSKKISAILARLPLVRKFALRLMAVTQSLFQFFSKIYPEFEQISSKVFHLEPLTGPELVANFSIVVELDADGNIINSLQGNSHKLGLISQTTKVGDYLFFGSPYKKYLGRLFVGPPPVIEVDGKGVKIKTENDTDKNEAEGLEPGVLKNEEDEPQVVENFNKKTVEEAQEGQVEEFVGVKVEENIPEEDEKLVKEKVTVEHTEALETESHKETKDEKEQEPLQQNTEWSDVPEEDIEVKTKENQKDDRDLKKEVGKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUF8</accession>
    <name>A0A8J5MUF8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Homeobox protein goosecoid-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Gsc-L2</name>
        <name evidence="2" type="ORF">Hamer_G017215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUF8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="379" mass="41970" checksum="AC955958BA3C477E" modified="2022-05-25" version="1">MRRAKETQEEVEVLGEVLVRRPAVLVSGALVLLGVIDCMVSLACVTISAREACGLYSKGEDNAQGLSEGHNRKERLYRWLGQQKTIFPIGSSSGPPRGVSSISQFVPLSSSDSSSSATPRKTLTDPSGVSSIPSSSSHRIHHQTATPPLATPSHISSSVKGGGSKVAPSSVPSILKPPSHPVTSGSHSLPQLTSKHHSSTQNYERRHSIHPHMQAAYPHLQHSLHMHHLHPHPHAHPHPHPHPHHISQKAHAHPHQYPQLPSSHPHHHPQLSHTPQHAAHPSLYYPHLVTPMMPHFPSDQDHHQQARTHKKKDSKKRRNKDGKKDKKKAKKSKELTDEQIERTYTGLDREIAEEFIDSTMEPGISIQRALNSTFDQDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWL9</accession>
    <name>A0A8J5MWL9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G011905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7165982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWL9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7165982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="322" mass="36525" checksum="9523C911EABF7B6E" modified="2022-05-25" version="1">MVPGVIKEGVGTVFIRVGVERRGSSLVAPVEEDLKRPHHHATVPAYRNTKQRYHKISDSVLSRTTRLHTLQDAKQRVVAVAAAVVVLCVVTTQASQDTLLQEVLKDSQELHQPIKDLIEQLTEEGKDWFRKTGQEQQETERTSNKQDEEGTRNKQEGGTRNKLDQESTRKQEGVNSKQQRNNESIENREKQNKENQVTEQQQKQQKQQQQGNNNKRTGREVQDAAGGTEEAGRLFLTGLDGTEQVTINLQGLLASLVYTVLGVLLFKVLAAIITGQNLSYWWNNWASRLLPTQDYSSGYYTDQSTYTAYRALDDVAKKYREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXK3</accession>
    <name>A0A8J5MXK3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020459">
        <property type="protein sequence ID" value="KAG7168140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXK3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="7723" checksum="0A759A71E4206520" modified="2022-05-25" version="1">MNTSLLEATSKSCAAGTKNDSSDSDSSSSSSSSSSSSSSDGGGHHKKKKKKKKKKDDHHHHHHHDHHHHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXW5</accession>
    <name>A0A8J5MXW5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposable element Tc1 transposase-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tc1a-L10</name>
        <name evidence="4" type="ORF">Hamer_G005361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXW5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="3">
        <location>
            <begin position="74"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7167044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="184" mass="20957" checksum="BDF6FBB5AA2895F3" modified="2022-05-25" version="1">MSRRVTTRDDIAAVIALYKANHVLREISAQTGVALRVVQNLVKRFRDLGEDELPAPLPKSGRPKLLSPRTLKVISRQVRSNPSLTAHEVKERNPRLLSHVSLSCVQQALHGDLGFKSFRACRKPLLTKRQKENRVKFCKKYEVWDLETWRSVLWSDEATFSVTGSNGGRVYRPPTQTRTSHSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY29</accession>
    <name>A0A8J5MY29_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Psma6-L</name>
        <name evidence="13" type="ORF">Hamer_G016806</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).</text>
    </comment>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Interacts with ALKBH4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020459">
        <property type="protein sequence ID" value="KAG7168173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY29"/>
    <dbReference type="OrthoDB" id="5835702at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000020">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5 10 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="12">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7168173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="246" mass="27579" checksum="8E72F71A85402D44" modified="2022-05-25" version="1">MARGTSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVSCKGEDTAVCVTQKKVPDKLLDPNTVTHMHKLTKNVGCVMTGMQPDSRYQVMVAQSEANNFKYRYGYDMPIDVLCKRIADINQVYTQNAEMRPLGCSMILIGYDDELGPCVYKTDPAGYYCGNRACSAGVKQTEANSFLEKKYRKKTNYTHDETIQLAITCLMTVLSADFKPTEIEVGVVSKEEPKFRTLTEQETDFHLSAIAERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYN9</accession>
    <name>A0A8J5MYN9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase chain 4</fullName>
            <ecNumber evidence="3">7.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ND4-L</name>
        <name evidence="9" type="ORF">Hamer_G002447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYN9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="8">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7168411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="109" mass="11876" checksum="CBE3466D83A48ED2" modified="2022-05-25" version="1" fragment="single">MLRMWIMALVICASQRINKTNNSPRGGSLTMGLVPWVERSNFITFILYFCKIFAFVAHVEAPVAGSIILAGVLLKLGGYGIIRVDIKPLVAYSSVAHIGLILRGLVVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0F8</accession>
    <name>A0A8J5N0F8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">A disintegrin and metalloproteinase with thrombospondin motifs 16-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Hamer_G025098</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013574">
        <property type="protein sequence ID" value="KAG7170768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0F8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF249">
        <property type="entry name" value="SOL NARAE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13574">
        <property type="entry name" value="Reprolysin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="10">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="223"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7170768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="271" mass="29182" checksum="99D3FD5D908DFECB" modified="2022-05-25" version="1">MCRRAFSGGVCNRGTAGFAYVGGACVVNKRLQKVNSVAIVEDTGGFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGARRCRWEDGYIMSDLRHTEKGFRWSSCSVEQFHHFLNGDTATCLYNLPHEDESLPRVLPGKLLSLDAQCKKDRGTSACFKDDRVCAQLFCFDSSSGYCVSYRPAAEGSDCGNGKICSNGRCVFDNGNSISDFDISRRRCAAVASEGRGGRTWPRATPGEGFKHPRPHPIPKMARGQPTSRGTSGFTHLEGPLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0J5</accession>
    <name>A0A8J5N0J5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polehole-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0J5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035212170" evidence="1">
        <location>
            <begin position="28"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="438" mass="48913" checksum="BD15349828E892B7" modified="2022-05-25" version="1" fragment="single">MYRRRGRVCSTTLLGMFMWATIITASATITAVDFDTPHMALPGLPSIEDLMDSVPDQPFETLADVDAFMTSLMDLADLYLEKAFTAHTHRYKRALDVTSVTVTGTQIYNFNFFNPTEFNAASLERVSGRQLLATPEKVYWILGYPRSGWQSVIEMSRLDYRIKLLAKFRLESIAIDKIDRITLPNRLYVLIDNYFDRRDDVQLKMKGVQDITGFTDSKSFYYLVFGSGPQGKITLYSDDMTGHYFPTFTIDTGCHTVQDLRGMKMGPDYVITYICLGVDGTAISLQARSLILEELKLAELETTADDLLHCLDKADMLLDSRKPNITYLADLTISGSMMTVNGPQTWTGLVTFSRGLTVTGTTTFNNRVDIKPSGNIVPTSGSLAKLFSDIDDLKSSVEDLAEDLDNLLYHSGDQTINGPITASTLTADKLEIDVLQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N192</accession>
    <name>A0A8J5N192_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dyslexia-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Hamer_G013799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012455">
        <property type="protein sequence ID" value="KAG7171334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N192"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000061">
        <property type="entry name" value="Dyslexia-associated protein KIAA0319 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029865">
        <property type="entry name" value="KIAA0319-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46182">
        <property type="entry name" value="FI19480P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46182:SF2">
        <property type="entry name" value="FI19480P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22352">
        <property type="entry name" value="K319L-like_PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7171334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="183" mass="20140" checksum="444880999F20D899" modified="2022-05-25" version="1" fragment="single">TEIILCGNTSTDDHGIEEWEWTKGPKDSGKAVDMQDTRTPFLHLSNLEEGHYQFILRVTDSIGQSSNTSVYVYVQKPNLAAPKDKNVPPKANAGGDFSVILPASVVRVDGSKSNDDVAVTRWLWERDATSLAAGKVINGSDHSPVLMVPMLLKVFGANSHLLFRIVIKDFNSPFINACRNNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2A6</accession>
    <name>A0A8J5N2A6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Longitudinals lacking protein-like 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lola-L16</name>
        <name evidence="10" type="ORF">Hamer_G000848</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2A6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016199">
        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008406">
        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035167">
        <property type="term" value="P:larval lymph gland hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007526">
        <property type="term" value="P:larval somatic muscle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045476">
        <property type="term" value="P:nurse cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007464">
        <property type="term" value="P:R3/R4 cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045467">
        <property type="term" value="P:R7 cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF111">
        <property type="entry name" value="LONGITUDINALS LACKING PROTEIN, ISOFORMS F_I_K_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="8">
        <location>
            <begin position="82"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="464"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7171911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="592" mass="64395" checksum="3D55F62E257CB79A" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3U5</accession>
    <name>A0A8J5N3U5_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Putative Interferon regulatory factor 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">IRF8-L</name>
        <name evidence="2" type="ORF">Hamer_G028575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010217">
        <property type="protein sequence ID" value="KAG7172867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="60" mass="6753" checksum="FA04C5A2F15E57A4" modified="2022-05-25" version="1" fragment="single">KTIMTPAAITDAPMDLSMKTRRKLRLEEFLRQNLDQAPAGRVNQPAFLSRAKTKPKNGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5C8</accession>
    <name>A0A8J5N5C8_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Carbohydrate sulfotransferase 1-like 3</fullName>
        </submittedName>
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        <name evidence="2" type="primary">Chst1-L3</name>
        <name evidence="2" type="ORF">Hamer_G021596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
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        <lineage>
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            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008938">
        <property type="protein sequence ID" value="KAG7173788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6138663at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13469">
        <property type="entry name" value="Sulfotransfer_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
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            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="476" mass="54318" checksum="2C8EDD1C4A4A9422" modified="2022-05-25" version="1">MTQTRVLGSKGRRLLLVLLLVSLLLASHIITNHAHPELEEVNGELPNTFTDPRVAAVEVKGAEPVNTRAAKSTSTYISQRLGREMEIKQKLLSKFEELDAKELQHVLQLLESTRNPRAVQATRIDHALQSLKVTLLEEISGKKYSDISKAVIHAQTITSQPRPAPLKFVLSTMAQVVIATTWRSGSTFLEELLASYPAVYNHYEPLMQFGLRRIREGLPGAAEAQETVHDLLSCKYEGHEDYILTAQKLKEMISRNTRLWNTCNTKEWGDALCFNDVFLKEACKLFPWSIMKIVRLQLKLLRPILEDSQLNTRIVYLVRDPRGVINSRTDTVRWCHTEDCKNPENLCRDMDDDLTTALQMQKDFPGKVYILRYEDMSLEPLNKTHELLEYVGLDFDPRVKEFLVSHTTKNFDKPWSTSRESKTRVTYWVSKLPSSKLKVVQSACTPVMKRFGYIPITSNKNITVENILGPLVLPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5L3</accession>
    <name>A0A8J5N5L3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Hamer_G000641</name>
        <name evidence="20" type="ORF">Hamer_G000661</name>
        <name evidence="15" type="ORF">Hamer_G000943</name>
        <name evidence="10" type="ORF">Hamer_G002570</name>
        <name evidence="22" type="ORF">Hamer_G004013</name>
        <name evidence="8" type="ORF">Hamer_G004605</name>
        <name evidence="9" type="ORF">Hamer_G005583</name>
        <name evidence="6" type="ORF">Hamer_G005917</name>
        <name evidence="7" type="ORF">Hamer_G007917</name>
        <name evidence="18" type="ORF">Hamer_G009885</name>
        <name evidence="12" type="ORF">Hamer_G013569</name>
        <name evidence="13" type="ORF">Hamer_G013572</name>
        <name evidence="14" type="ORF">Hamer_G014795</name>
        <name evidence="17" type="ORF">Hamer_G015153</name>
        <name evidence="5" type="ORF">Hamer_G015832</name>
        <name evidence="3" type="ORF">Hamer_G027741</name>
        <name evidence="2" type="ORF">Hamer_G028029</name>
        <name evidence="4" type="ORF">Hamer_G029845</name>
        <name evidence="16" type="ORF">Hamer_G030139</name>
        <name evidence="11" type="ORF">Hamer_G030525</name>
        <name evidence="21" type="ORF">Hamer_G031738</name>
    </gene>
    <organism evidence="16 23">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045875">
        <property type="protein sequence ID" value="KAG7153960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010043631">
        <property type="protein sequence ID" value="KAG7154876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010040537">
        <property type="protein sequence ID" value="KAG7155780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010038275">
        <property type="protein sequence ID" value="KAG7156908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010022531">
        <property type="protein sequence ID" value="KAG7166472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010018675">
        <property type="protein sequence ID" value="KAG7168842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010008793">
        <property type="protein sequence ID" value="KAG7173825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7174950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010001040">
        <property type="protein sequence ID" value="KAG7177927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5L3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7155780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7156908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7157474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7162390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7163455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7166472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7168493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7168842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7170726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7170727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7171652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7171983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7173825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7174950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7175856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG7177322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG7177334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG7177927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG7178209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="263" mass="30088" checksum="FD92EA80AC874B73" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDSSSDEQEATSDDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5V0</accession>
    <name>A0A8J5N5V0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009700">
        <property type="protein sequence ID" value="KAG7173485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5V0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="112" mass="11790" checksum="F601881859A5EDA6" modified="2022-05-25" version="1">MIKSSSFPPSIHPRSVASAGAPLFHVMVGRGTGREGGRARLTVGPAPLITAPCQCEETQRASVSSAVVESSAAPPQPAPPPSSRWPVSCRRHDPRWCLLAGAAAGRRRLMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5V1</accession>
    <name>A0A8J5N5V1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lachesin-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Lac-L8</name>
        <name evidence="4" type="ORF">Hamer_G017806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007950">
        <property type="protein sequence ID" value="KAG7174081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5V1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="43"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="133"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7174081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="394" mass="43061" checksum="422107D0CD546FBC" modified="2022-05-25" version="1">MTVDGSRLTISHTRPRDAGTFLCQFDLEPPLQLKHTLDVQYAPTVRSLVPPEQRVAKGKGVTLECTARGNPEPIIRWSRQEGPLPSGQRSQQGHRLTLDAVDRHMEGTYLCTADNGIGEPASAAMALTVEYPPEITTEKDIVRTGEGDQVELVCVVHGLPPPDVVWTRDGRPLPDTIMDTKLHLPQQPGGRAHASYDAHVSQTHFSHRHTLTISHVTEKDFGAYVCIAENAHGQKSAVIQMTGLPKPPVVTSSPNGGESSRYTLTWETESYYPITEFLINVNKSATCTQRNHTVVMAGSWENVSRAVGSDEAVVSKETHHHAMVYTLEGLQVATDYVAVVRVRNKYGWSAESNNFSFSTKKAMAVLQSTSGESGQTGTSGFILLLVLPLSLTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6E1</accession>
    <name>A0A8J5N6E1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6E1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="294" mass="32045" checksum="99F8C2DB4E987F7D" modified="2022-05-25" version="1" fragment="single">ESRSVTDELRLLESQIKLKEVGIRQVEAEAKAKEAEAIAKREELDAYGGKPVHKAEVCRTRLQLNTGKPAMIVTEETNTSPVGVMADLSKADSMPIGLVFTKGEVWRVQFRYSPHETLILSRRVLRRTQTLVPFVPFCHKARVVAARKTDKYVVLGSLWGQGVAPLVLVHVKSSCFSGIANVTCVHELPVAGVDLILGNDLAGGQMGNVTPPPVLREKPESTVELQQLKDDMPDVFPLCAVTRSMSMTNDHNVTPVVDDSLSLEGLFANPIASQDISSAVNAMTRRVALIAAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7S6</accession>
    <name>A0A8J5N7S6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7S6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="101" mass="11944" checksum="DA759DE2F03E9345" modified="2022-05-25" version="1">MKRNALRWYGHVPRMHEDRLTKKVYDSKREGNVGRGRPIATWEKRVREFVEERAGRGGRVFERASEIEMCKDKITWRHFCHLPPLVREFPGGNKALAILID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8M3</accession>
    <name>A0A8J5N8M3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CENPB DNA-binding domain containing protein 1-like 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G024249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004580">
        <property type="protein sequence ID" value="KAG7175926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8M3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="86" mass="9369" checksum="DD2D3F9C86CEFB6A" modified="2022-05-25" version="1">MPKRPATKTASNVAKRSCVAVTLDVKLDIVKRHEHGEGMSVIGRVHGLAHSTVHSIVKSSDKIKEMAGSTTPLTTTKVTRFRDVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9D4</accession>
    <name>A0A8J5N9D4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DDE superfamily endonuclease domain-containing protein 36</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Putative DDE superfamily endonuclease domain-containing protein 37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G029850</name>
        <name evidence="3" type="ORF">Hamer_G030398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031200">
        <property type="protein sequence ID" value="KAG7160631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010005987">
        <property type="protein sequence ID" value="KAG7175477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9D4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="152"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7160631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7175477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="348" mass="39531" checksum="D2A62950A18F9352" modified="2022-05-25" version="1">MPRRHRITSATDRERIIEAYRAEQDFLVVAAALGVQRTTAYSIVRVYQRENRVEAAHTGGRHKIIDNETLDLIVMLLEASPMMTLREIKEEVMDIFPTKPHFSEVTLSRYLEGELISLKMSRDSPAERNSPAVKEARHAYAMWMLATGLQQQLVYIDETGFNLWTKRTYGRARCGERVHRAVGGQRGRNTTVIAAIAEHCGILYHEIHYGSVTKEVFSDFIASLAAIIGDARSILVLDNAPIHNGIAAVYPELNFKFLPPYSPCLNPIENCFSVFKSYLKQYLHREAPRCNAAQARQEGVTLNALRENILQVGVEFALPSVTEHVVSQNYNHVNTYLVQCIERRDIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCI2</accession>
    <name>A0A8J5NCI2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-directed DNA polymerase from mobile element jockey-like 60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCI2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="543" mass="60285" checksum="BBFC8A480970FE05" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCV4</accession>
    <name>A0A8J5NCV4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCV4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="214" mass="24503" checksum="0EB28269C50A7441" modified="2022-05-25" version="1">MEESESQSGENAKGTVRPTSSTTRSATEIYLVGQPASSIRGSKLPTMRQVLKFFFHTVNESGDRQETFKETVRNVLTFWNLARIKTISERGCREKLTRLWEHWRSLQNSRDRAAKDKVENFKSQLDLLWDIGAPDAVEDIEKNRLLTPADKQQDIAFYQDQHGERKAFMSGNDKIFAAKKRKQEERVEKQRSKQGRFAACEPSSSDSRPQTCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ND23</accession>
    <name>A0A8J5ND23_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ND23"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7178190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="164" mass="18861" checksum="9EC7FB62E6FCAB44" modified="2022-05-25" version="1" fragment="single">MLSDVFSLICGSTGSPETILFKRFKKQWRSISLNDFIPAPESIFWHEAPMAVRAPFSDLQLMKVLKEYPHEKVAHAAQAAISRHLWYLSEHLIGLSLFDDRIDTETKKSMVQNFQCPKKQDFSRRIVLSDETPISNVASFVTERTLDIFDVLTLDGKERAQLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NER2</accession>
    <name>A0A8J5NER2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NER2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035219214" evidence="1">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="74" mass="7882" checksum="C90800F580F9E2DA" modified="2022-05-25" version="1">MASQGAHPACLFLALTLLITGAATAILCSAILTNHWEVITFDKTRVASIAAKHNATHTLTWLWNGKVGKVSVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T1M2</accession>
    <name>A0A8J5T1M2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G000710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T1M2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035204835" evidence="2">
        <location>
            <begin position="26"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7171796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="767" mass="84900" checksum="40D62F724D046C17" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T6Y6</accession>
    <name>A0A8J5T6Y6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G008562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T6Y6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="390" mass="43568" checksum="2BB4B5A4F6B03D82" modified="2022-05-25" version="1">MDSCGAVLLGNKRPRLHLGCILDTPGRSYGVYFFIVHNIKDIINANSIMKAMFTRDASVTWLKDELLQVEDERVLARGWWLVGDMQRTLCPKAVGCFTLDNHCFVAVGSFVATYVVILLQFTTNNTTSAFTTSHPPTTASIIRVFFSSLLRLVFICLITCFMRTLAKTLTETRRAIATHLESNDRLAYVTCPISPVDDPGTRDLSKSHHDARHLNTMGATHLRTSARGQDWSLHDLVPTSVINEAQLKTFESLLRQVETLQDRVFDYFGPPLICHFLNIVLSSIADTYFLFNFEPVFTRSCLALLANILSLVVILHGTWIMQKEGWWLVGDMQRTLCPKAVGCFTLDNHCFVAVGSFVATYVVILLQFTTNNTTSAFTTSHPPTTASSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TAL2</accession>
    <name>A0A8J5TAL2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009150">
        <property type="protein sequence ID" value="KAG7173640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TAL2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="321" mass="37486" checksum="642E5FCD024FF6B3" modified="2022-05-25" version="1" fragment="single">MAESVEQGSTIVGDTLAERLEEALLINARQYSALEESQTQVKELKQELQELKQTLQHAQGPNNEQESVVGDDTTPLPNSRNTVNVNIPCHFNHTDKLTLEELQSLQVNEVLSKFFRKVERCVTEDEGRISTALNWMENSVAKLVRPLLVAVSEDWDSFRKVMLRLKLGPSTEDEAWEVLKRIVYNVNDNPRYYVCDMRARLAVMEKKFGAITTKDTYIIQRLYRAVPKPMQRDLTPYIQDCRTLDSFVRMLERSRSEYLGGDSRDLYHVRQSRQEQVQPTTDFENYRVRGDYHMNETDGRRAQNTRWKENNTQNWTGNEWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TC46</accession>
    <name>A0A8J5TC46_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutamate receptor ionotropic, kainate 1-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Grik1-L4</name>
        <name evidence="9" type="ORF">Hamer_G020029</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008712">
        <property type="protein sequence ID" value="KAG7173881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TC46"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7173881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="289" mass="32581" checksum="7EAB02EA3149510E" modified="2022-05-25" version="1">MIRARLPVVDYSRIYTDDPIDISLKPQPLPQYLYHQSPGSDEHHGMGPHRLVPAEGVVVGEWEAGCWAGLRPPNSWRVISNPSQHTTNMIDQAYKSSLVAHLTVQSKSSPINSFEDVLGQTSWSWGGQAPLLHSAYAQVFTKSPSSTLQDIYKHMEIRDVDDGLARVMENGYSFITWKYYIESIIAITYTDTRGVTAFYTSRKEYSLLLGHNWGFTKGSPLRRPISAIKQRPDRGGAHRLLDGSRVDDGQVVLSLHHLQSVFFLLLLGYCVSCLVLLGEKVSYYLQRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TDB4</accession>
    <name>A0A8J5TDB4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane dipeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011977">
        <property type="protein sequence ID" value="KAG7171693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TDB4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21560" checksum="5F137492CF6DF0E1" modified="2022-05-25" version="1">MVTVVRDEPSGADGRSRVSHLTSLPQTVVRDEEPLGLMVDLSHVSLTPHFSPQTVVREMNRLGLMVDLSHVSLLTSPSTVVREMNRLGLMTVVRDEPSGADVSHMCLRRAMRGAGGVKSAGHLQPLRVLYLTHQPRQEGGRRQPRRNWCRFRRYKHVGVDLQQQRVKAGGRVARSPEDEAASTASPDRLTMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5THR7</accession>
    <name>A0A8J5THR7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Silk gland factor 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SGF3-L</name>
        <name evidence="11" type="ORF">Hamer_G022397</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006025">
        <property type="protein sequence ID" value="KAG7175469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5THR7"/>
    <dbReference type="OrthoDB" id="6358449at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002805">
        <property type="term" value="P:regulation of antimicrobial peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000005">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000001">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF89">
        <property type="entry name" value="POU DOMAIN PROTEIN 2, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="POU-specific" evidence="10">
        <location>
            <begin position="157"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="247"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="249"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7175469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="395" mass="43689" checksum="493D1CCA88F1F18E" modified="2022-05-25" version="1">MATTTYIASSAVCSDPVSVPDCLTMNIVNNPGYGREAHEMKYMPQHQAPMAHNPWVGLPPSDPSHWAMHSHPGLHQDIKPQPSEVAIHHRPVHHMTHGWQPPVSSPYSLAAGNGGSPLGHHYINGMMPHQMHPGHLRDMPCESPGTPDHHIHHEVEEETPTSDDLEQFAKSFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLMKWLEEADSTTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALEQHFHKQPKPSAQEITQLADSLQLEKEVVRVWFCNRRQKEKRMTPPIIGQGPDGQGVNGTPPGPGQQITPTPDYGQPRSVELPRELKYTGYTHQTMHGSPTHLPPQHSPPGPLLSPQMPPHSVAPSHAVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIL1</accession>
    <name>A0A8J5TIL1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neuroparsin 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Np3-L</name>
        <name evidence="2" type="ORF">Hamer_G006954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIL1"/>
    <dbReference type="OrthoDB" id="5976811at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010850">
        <property type="entry name" value="Neuroparsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07327">
        <property type="entry name" value="Neuroparsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035200624" evidence="1">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="98" mass="10076" checksum="A5C48FEA0787D07E" modified="2022-05-25" version="1">MRSLGFVTSIAVIVVIVIVNETGAAPRCNQGGNRLPANNCKYGTVVDWCGGSVCAKGPGEACGGEWSENGECGAGTYCSCGYCNGCSANLECWFGSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIN7</accession>
    <name>A0A8J5TIN7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polycomb protein Asx-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Asx-L</name>
        <name evidence="12" type="ORF">Hamer_G017003</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Asx family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7176039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035517">
        <property type="term" value="C:PR-DUB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026905">
        <property type="entry name" value="ASX-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024811">
        <property type="entry name" value="ASX/ASX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578">
        <property type="entry name" value="ADDITIONAL SEX COMBS LIKE PROTEIN ASXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578:SF20">
        <property type="entry name" value="POLYCOMB PROTEIN ASX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13922">
        <property type="entry name" value="PHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEUBAD" evidence="11">
        <location>
            <begin position="314"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="180"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="429"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="750"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1145"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1259"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1319"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1391"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="750"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1159"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1178"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1328"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1391"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1408"/>
            <end position="1419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7176039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1535" mass="159707" checksum="866C4B0452582F2C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIQ6</accession>
    <name>A0A8J5TIQ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004209">
        <property type="protein sequence ID" value="KAG7176099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIQ6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="290" mass="30752" checksum="AAF342D43BFE3F81" modified="2022-05-25" version="1">MIVSAEANTSPVGEMAGLSKADSMPIALVSTKGETRESAVSVLASRDFDLFQESFAKDPDVGTFRPFLSQGTVEVDGVETPVTILRDSGCLQTLIKEGVVAARKTDKYVVLGSLWGQGVAPLVLVRVKSSCFSGIANVACVHELPVAGMDLILGNDLAGGQMGNVTPPPVLRERSESTAELQQLEDDRPGVFPLCAVTRSMAMTIDHYVTPDVDDSLSLEGLFANPIASQDISSAVNAVTGRVALIAVQEQDDSLRLLFDQVSDSANDSDPTTRHFSQDGTRSLHKATNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJH5</accession>
    <name>A0A8J5TJH5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Glycine receptor subunit beta-type 4-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Glrb4-L3</name>
        <name evidence="14" type="ORF">Hamer_G020778</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004696">
        <property type="protein sequence ID" value="KAG7175710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJH5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="35"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="162"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7175710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="339" mass="38798" checksum="DCD85ADA40EBA07D" modified="2022-05-25" version="1" fragment="single">TGGWEVLALTLNYVKWTLSSTLPTTTVGRHPPPIQDYSVDLYLRQRWVEHRLNGSLVRPLDSNDPTLVKMLWKPEVYFPNAKDGDFQYVTVPNVLVRIYPDGSILYILRMKLRFSCMMDMSTFPLDHQTCFIQVASYPIKMYKDLQLPQFQRNVGYHLVQSYLPTSLIVVVSWVSFWLDVDAIPSRVTLGVTTLLTVCSESSAFRDKTPAVSYVKALDIWMGSCTAFVFLALVEFTLVNYLGRHKRRFLFWSTYSHPQQLSRSTSLHQAQRLTSFGSSTKGVVTVEADGSSVEGVTRPCMPVAWRREADLAKKIDQTSRAVFPLLFVAFNLAYWVYYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJV3</accession>
    <name>A0A8J5TJV3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transport and Golgi organization 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Tango6-L</name>
        <name evidence="7" type="ORF">Hamer_G020131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009549">
        <property type="protein sequence ID" value="KAG7173508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJV3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057407">
        <property type="entry name" value="HEAT_TANGO6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019414">
        <property type="entry name" value="Rtp1_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057347">
        <property type="entry name" value="TANGO6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23565">
        <property type="entry name" value="ARM_TANGO6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10304">
        <property type="entry name" value="RTP1_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25267">
        <property type="entry name" value="TANGO6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TANGO6 N-terminal" evidence="6">
        <location>
            <begin position="99"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="TANGO6 HEAT repeat" evidence="5">
        <location>
            <begin position="414"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="4">
        <location>
            <begin position="875"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="1075"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="770"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="846"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="770"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7173508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1134" mass="125858" checksum="E3A40061A01A3731" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLL8</accession>
    <name>A0A8J5TLL8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoglucanase</fullName>
            <ecNumber evidence="9">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">celD-L7</name>
        <name evidence="11" type="ORF">Hamer_G015113</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7174918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLL8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033126">
        <property type="entry name" value="Glyco_hydro_9_Asp/Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00698">
        <property type="entry name" value="GH9_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="10">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="10">
        <location>
            <begin position="67"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7174918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="157" mass="17668" checksum="0453D1C5C7B5F206" modified="2022-05-25" version="1" fragment="single">IVAHDDMTTYRSWSGYGDELCWGALWLYRATGNEAYLTKARAAWDEFDLGTDAIQFSWDDKRAGCYGMVFLDMWGANRHCANVAYIALWAAQYGDQSKSDKYREWAQGQINILLGDSGHSFVDGTYSDDRNDYVHNEVACDYNAAFTGAIAALVELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLV1</accession>
    <name>A0A8J5TLV1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-associated and pleckstriny domains-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RAPH1-L</name>
        <name evidence="4" type="ORF">Hamer_G015149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7174947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLV1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01259">
        <property type="entry name" value="PH_APBB1IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16138">
        <property type="entry name" value="RA_MRL_MIG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039664">
        <property type="entry name" value="GRB/APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039665">
        <property type="entry name" value="PH_APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243">
        <property type="entry name" value="GROWTH FACTOR RECEPTOR-BOUND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243:SF23">
        <property type="entry name" value="LD06925P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="117"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="247"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="946"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="785"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7174947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1012" mass="110066" checksum="55EA1D50F460D740" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TM98</accession>
    <name>A0A8J5TM98_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vitelline membrane outer layer protein 1-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">VMO1-L5</name>
        <name evidence="2" type="ORF">Hamer_G001225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TM98"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.20">
        <property type="entry name" value="Vitelline membrane outer layer protein I (VOMI)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005515">
        <property type="entry name" value="VOMI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036706">
        <property type="entry name" value="VOMI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18841:SF0">
        <property type="entry name" value="VITELLINE MEMBRANE OUTER LAYER 1 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18841">
        <property type="entry name" value="VITELLINE MEMBRANE OUTER LAYER PROTEIN I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03762">
        <property type="entry name" value="VOMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51092">
        <property type="entry name" value="Vitelline membrane outer protein-I (VMO-I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035200631" evidence="1">
        <location>
            <begin position="26"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="201" mass="21054" checksum="8A34176504877A31" modified="2022-05-25" version="1">MPGGGMVEVWVVMGVLWAVLTPALATNNTRIYKKVSSNVQITSDILASYSLPGSEEYANSTMATDHVGVSIIQVTCIYPGGAPASVLTQGVTDFIPAGTWSVLECPGGTWMKGFTQAVTPTLGGGDDDALANMRLYCSQDSAGSGVGTELTVNSDSRNPWGTPSLCPEGFVGCGLRAQVEPKHYLDDSAISTVTFKCCLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TNP6</accession>
    <name>A0A8J5TNP6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exportin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Xpo4-L</name>
        <name evidence="10" type="ORF">Hamer_G017025</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7176057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TNP6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF1">
        <property type="entry name" value="EXPORTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7176057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="990" mass="112096" checksum="8D734F100A799ED0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TTR7</accession>
    <name>A0A8J5TTR7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ERGIC-53-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Lman1-L1</name>
        <name evidence="11" type="ORF">Hamer_G000289</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TTR7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000028">
        <property type="entry name" value="Blast:Protein ERGIC-53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035196221" evidence="9">
        <location>
            <begin position="27"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="10">
        <location>
            <begin position="31"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="347"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7177063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="395" mass="44333" checksum="86F5259FCC72E9E6" modified="2022-05-25" version="1" fragment="single">DTQQVAEMDLWWLLTLLLPLLCVTYAQNPHRRFEYKYSFKGPYLAQKDHQVPFWQYSGNAIASEESVRITPSLRSQKGQIWTRSPTNFEWWEVDFVFRVTGRGRIGADGLAVWFCDKPGVEGPVFGSMDKWNGLGIFFDSFDNDNKRNNPYIMTMVNDGTKVYDHEHDGLSQQLGGCLRDFRNKPFPVRAKVEYYKNTLTVKTQLLEYDYTKLEEEGDQYAYSITSKPEGTEPPLRSVEGSPSQDPLSTSYPSADLTTSSLPPGSDDYTATTSQPPSDVDSTTMSSFFGFGGETASSTPSPNDESTTTTANPAVLGDDDFTRDVLDAGHLFVETVHNAAEDELSAGWGWLGSDEPTVTTTPKPEKKRRRKKQRKRRGRSRKKVQSNIPVGGHDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TV61</accession>
    <name>A0A8J5TV61_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G025976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001765">
        <property type="protein sequence ID" value="KAG7177798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TV61"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035299228" evidence="2">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="106" mass="11733" checksum="6AEA54B1E22E4048" modified="2022-05-25" version="1" fragment="single">MRIVLLCLLVVFAEVHGSLLDGLEHHHGDHAHGEHAHGDHAHGEHAHGDHAHGDHAHGDQGGDHAHGDQEETTPTETREETTPYETREETTPRRRPHEEQGGDHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J2E2</accession>
    <name>A0A8J5J2E2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G025236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046608">
        <property type="protein sequence ID" value="KAG7153552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J2E2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="336" mass="36077" checksum="51E9A80C4A8F1FE2" modified="2022-05-25" version="1">MGAVLLACGLLQAGATIHVVYRLELWYVVCKAGAAVLCGLQAGATGMIYRAELLLWHVVYRAGATGMWSGAGATVLCGLGSWSYCKLVLLWCAGLQAGATMQFTGCGFCRIQSTELLLLWYAVYRAGASVSITSLELGFYNMRPELLQYAVYRAGASIICSLGAGASIICSLQAGASIICSLQAGASIICSLQSWSFCVTVYGAGACAGATIICSLQGWSFCNMESYRGWSFCNMQSMRLGFCNMQSTGAGASAGASIICSLSWSFYNMQSELLASIVCAVYRLGYSMQSQDFCNMQSTERWSFYDMQSTELELLYMQSAELELLYAVYRAGASII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JD21</accession>
    <name>A0A8J5JD21_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Accumulation-associated protein-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040843">
        <property type="protein sequence ID" value="KAG7155715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JD21"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="157" mass="16345" checksum="B7F3235EB5C4A919" modified="2022-05-25" version="1" fragment="single">IVRLRGERLTEVNVWLVENSSKQTPHKVKHFHSAIGVQCPDCQHLEYKPLQTPPSASAFTSASASTSASASTSASASTTTNASPGTNASPGTNASPGTNASPGTNASPGTNAFPGTNAIPQQATRGLPTLNNNYILHLILQTTKRNGSVRDIQTSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JG13</accession>
    <name>A0A8J5JG13_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G006633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JG13"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="105" mass="12033" checksum="B31FD9E1D7C1A704" modified="2022-05-25" version="1">MKRRSRVPRAIFFWRPHRSLLNTSFKTSSSVTTPPQSTHKLFLLLMVQWQQTVYWRPRKKLLAGSQITVLEATNTPPEVHLFTHLPGQLATCPLSPTITLVAIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGW3</accession>
    <name>A0A8J5JGW3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035946">
        <property type="protein sequence ID" value="KAG7158027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGW3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035313581" evidence="1">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="81" mass="8869" checksum="10749624A0A1AF93" modified="2022-05-25" version="1">MARYLTCLTWALLLALCYTPTPALPQEVGSLPDFHLLVYDGGVNADNPSSGVIIRGKKGSTDRIVPIKKGPPLEDYFFQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHC7</accession>
    <name>A0A8J5JHC7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037885">
        <property type="protein sequence ID" value="KAG7157231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHC7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="106" mass="11922" checksum="8AF218987CE2494F" modified="2022-05-25" version="1">MLPPETKLTRHCESCGVSPEDCLKKLGLHSDHVGLLSPSPKSERLLHFFRNIQPVPPRPHPCHTPIGSDPHLEKSHQEAPRPQSRSLTTSPTHSEDDSRKPRLNTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHM2</accession>
    <name>A0A8J5JHM2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040691">
        <property type="protein sequence ID" value="KAG7155755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHM2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031389">
        <property type="entry name" value="RBIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15679">
        <property type="entry name" value="DUF4665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="98" mass="10718" checksum="284C5246C69F8CCE" modified="2022-05-25" version="1">MGKNKLHTKNPFKSGNPIYRKAGTGAPRKAKGKVKPVKTNLKQLKIANKEAVLSLDKRLGSFHEAMQKKGTSSTAEQPVKPTEKGEPPVDMEEAAQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHS0</accession>
    <name>A0A8J5JHS0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CUE domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Cuedc2-L</name>
        <name evidence="8" type="ORF">Hamer_G010589</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHS0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12493">
        <property type="entry name" value="CUE DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12493:SF0">
        <property type="entry name" value="CUE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="7">
        <location>
            <begin position="150"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7153294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="207" mass="22382" checksum="41E12CF6DBD67059" modified="2022-05-25" version="1">MSADADIVRSSLEKLLHDHSPSADTSGIDEIVVSYVSGVLEEVAVDDEEVDSAGMKDVMAAYVPEFDAIPEDAITSWVINMVHVINQEKSKAKAGKDLTLDALISSFPVETRKHCNSQSISETSERSQKLSETSNGSDEQNSTNGDEQDEYSEGLATLLEMFPGTCNLEVQHCLATCGGDLEHATTLILQRQEQGINIKTSTTSKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIW1</accession>
    <name>A0A8J5JIW1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Paternally-expressed 3 protein-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Peg3-L5</name>
        <name evidence="2" type="ORF">Hamer_G014925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035946">
        <property type="protein sequence ID" value="KAG7158041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1614" mass="164637" checksum="5BFC8BEF1A9F42AA" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ09</accession>
    <name>A0A8J5JJ09_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome-releasing factor 2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gfm2-L1</name>
        <name evidence="2" type="ORF">Hamer_G006336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJ09"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="155" mass="16662" checksum="A28EF0B76F073324" modified="2022-05-25" version="1" fragment="single">RPARWPAPAETVDHGASPPSTSGDNITQHWHHGTLMQVKQQPEAYVILQLCDKDDSVRSMMETLLWTTWSRREREASPSHQRPRSLGQPQNQPGGHPGHVDFTMEVGSSLQSLGRAVAIFDASAGVGSVPHCVASGRSLPGAATLLPQQDGQTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJV8</accession>
    <name>A0A8J5JJV8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ subfamily B member 8-like 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">DnaJ subfamily B member 8-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="4" type="synonym">Dnajb8-L2</name>
        <name evidence="4" type="ORF">Hamer_G025889</name>
        <name evidence="3" type="ORF">Hamer_G029309</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037575">
        <property type="protein sequence ID" value="KAG7157274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010011734">
        <property type="protein sequence ID" value="KAG7171737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJV8"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052276">
        <property type="entry name" value="Diphthamide-biosynth_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44240">
        <property type="entry name" value="DNAJ DOMAIN (PROKARYOTIC HEAT SHOCK PROTEIN)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44240:SF10">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7157274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7171737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="159" mass="18942" checksum="DD50AF949C8455B1" modified="2022-05-25" version="1">MTSHRQVLDVTSNATPTEIRQAYLHLARRCHPDKNPDDREATKTFQRIQAAYVALNEVQCGQNSSQTCEENNSPTSEEKYSQKSEEKKSQNWEEKKSQNWEKKKSQNREKKKPQNWETKKPQNWETKKPQNWETKKSHNWGKKKSQKQEKKKSQKLEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JL34</accession>
    <name>A0A8J5JL34_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acidic mammalian chitinase-like 10</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Acidic mammalian chitinase-like 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Chia-L10</name>
        <name evidence="4" type="synonym">Chia-L11</name>
        <name evidence="3" type="ORF">Hamer_G025123</name>
        <name evidence="4" type="ORF">Hamer_G027001</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033024">
        <property type="protein sequence ID" value="KAG7159660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010029005">
        <property type="protein sequence ID" value="KAG7161519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JL34"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF360">
        <property type="entry name" value="CHITINASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035391587" evidence="1">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7161519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="67" mass="7088" checksum="4380FDB74A12ADCA" modified="2022-05-25" version="1" fragment="single">MKLLVPLSLLALALAVSAADDGLMVCYYGSWAVYRPGNAKFDVEDIDPAICTHLIFGFAGLGGSKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLC2</accession>
    <name>A0A8J5JLC2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042269">
        <property type="protein sequence ID" value="KAG7155274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLC2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="120" mass="13094" checksum="8D3772490FE7395C" modified="2022-05-25" version="1">MPREERVNGNCNGKSSTTKHNRTPSEHIRVGSTATEKSQPNIHPAPTVRRFLPCTSPTRLQDKIEDTGTKSVHAGNHDKSADSTTTAPELYCSKSTEHSSSGGEHHIAWDTATPLKRPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLU1</accession>
    <name>A0A8J5JLU1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G021096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036637">
        <property type="protein sequence ID" value="KAG7157855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLU1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="78" mass="8254" checksum="D8777D40DFDAC597" modified="2022-05-25" version="1">MRHSAGTREGGDGGCGGVVSSGEIQYTTWLLGSPPPPPPTITTTVPHHHHHYTTLPPSSLTTTTTLPHWGGGLRVDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JM09</accession>
    <name>A0A8J5JM09_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Phosphatase 1B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Ppm1b-L</name>
        <name evidence="18" type="ORF">Hamer_G011420</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JM09"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000001">
        <property type="entry name" value="protein phosphatase 1B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.430">
        <property type="entry name" value="Phosphatase 2C, C-terminal domain suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012911">
        <property type="entry name" value="PP2C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036580">
        <property type="entry name" value="PP2C_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07830">
        <property type="entry name" value="PP2C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81601">
        <property type="entry name" value="Protein serine/threonine phosphatase 2C, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 16" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="17">
        <location>
            <begin position="23"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7158748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="389" mass="42859" checksum="5C99965FA43585C8" modified="2022-05-25" version="1">MGAFLDKPKTDKHNEHGVGNGLRYGLASMQGWRIEMEDAHVAVANLPGVLKDWAFFAVFDGHAGAKISAHCSEHLLNSITSGEEFQASSIADFETETEEKTINKIKKGIHAGFLRLDESMRLMPEVVSGEDKSGTTAVCALISPTHIFVANCGDSRGVLYRAGNIGFSTQDHKPVNPIEKERIQNAGGSVMIQRVNGSLAVSRALGDYEYKNVEGKGPCEQLVSPEPEIYVERRQDEDEFLVLACDGIWDVMTNEDLCAFVRSRLLLSEDHESISNHVVDTCLHKGSRDNMSLVLLTFPGAPKVSQEAIKKEKELEELIEKKVTEVCEQEEPVSMAQIMQVLADESIPNLPPGGGLTAKRGFVDQLFRKLRPECANSFYCTTTICCELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JN84</accession>
    <name>A0A8J5JN84_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0612 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G032063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030693">
        <property type="protein sequence ID" value="KAG7160800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JN84"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="entry name" value="Serralysin-like metalloprotease, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053108">
        <property type="entry name" value="Chlamydial_TARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36975">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36975:SF6">
        <property type="entry name" value="HISTIDINE-RICH GLYCOPROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="Adhesin YadA, collagen-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="481" mass="55162" checksum="D23F7B232D5312FB" modified="2022-05-25" version="1" fragment="single">VTSQMWEVTSQQWEVNTTMKGYTTTVRGYTTTVRGYTTTVRGYITTVRGYTTTVRGYITTVRGYITTVRGYITSVRGYTTTVRGYITTVGGYITTVRGYTTTVRGYITTVRGYITTVRGYITTVGGYITTVRGYTITVRGYTTTVRGYITTVRGYITTVRGYITTVRGCITTVRGYITTVRGYITTVEVTSQLWRLHYNSEGCTTTVRGYITTVRAQQRLHHNCGGYITTVGGYITAVEGCTTTVRLHPGCERLHHNCERLYHNCERLHHNCERLHHNCERLHHNCERLHQNCERLHHNCERLHHNCEMLHQNCERLHHNCERLHHKCERLHHNCEMLHHNCERLHHNCERLHHNCGRLHHNCERLHHNCERLHHNCEGYITTVRGYITTVRGYITTVGGYIKTVGGYITTVRGYITTMRGYITTVGGYIKTVGGYITTVRGYITTMRGYITTMRGYITTVGGYIKTVGGYITTVRGYTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNK3</accession>
    <name>A0A8J5JNK3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G032101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035255">
        <property type="protein sequence ID" value="KAG7158399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNK3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="210" mass="24727" checksum="9278A373AEA3D77F" modified="2022-05-25" version="1" fragment="single">IVLVRNTYTYSIKWRILLQRSTVQYSTVQASTVLVRNTHTALSGDSLYSTVQYSTALVRNKYTALSGDSFYSTVEYSTCEEHTYSIKWRLLLQYSTVQYSIVQYSTALYSTCEEHTFTIKWRLLLQYKQYSTCEEHTYSIKWRLLLQYSTVHYSAVQYSTIQYSTCEEHTYSIKWKLFLQYSTVQYSTVLVRNTHTALSGDSFYSTLQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JP90</accession>
    <name>A0A8J5JP90_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vasopressin V1a receptor-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Avpr1a-L1</name>
        <name evidence="11" type="ORF">Hamer_G007433</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JP90"/>
    <dbReference type="OrthoDB" id="6435638at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005000">
        <property type="term" value="F:vasopressin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15196">
        <property type="entry name" value="7tmA_Vasopressin_Oxytocin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF161">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="120"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7161787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="471" mass="52372" checksum="7B1887E63605594F" modified="2022-05-25" version="1">MSTTTPVMSTTTPVMSNTTPDMSTITPNSSNTLPNTDLFVTLSAEAVGRFMIKKMEELSTHLGLNTSTLYDELHSFAKDSFPASTGDVTTILAKEDFRNSALAVVEIVVLVLIMVVAVIGNVFVLIALWRHSLFQPMSRCYLFMLHLSLADLLVALLNILPQLIWEITYRFRGSDLLCRLVKYAQVFVLYVSTYVLVFMAVDRARAVQGSGRGSLRAARLMVAGAWVLGLVLATPQTLLFAVREVEPGVLDCWVVFELVSERMYVTWFVVSVFLLPLAIIAVCYGYICWAVWHSAGTTSPRSALRRRLCFGCLRWQSSAPSERRMSMELQPISRVRGGSHHHHLPHAITPVVDKVSAAKMKTVRMTLTIVFAFAICWAPFCIAQLLTVYNKPQDLSTMNPVAVVCMLLGSLNSCTNPWIYLYFSGTLLNQLRVVLGFGPSCSSDNVSIGDQEPQQRRHDPSRRPVTHSNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTY9</accession>
    <name>A0A8J5JTY9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="4">PARP</shortName>
            <ecNumber evidence="4">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Tnks1-L2</name>
        <name evidence="7" type="ORF">Hamer_G019634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010025477">
        <property type="protein sequence ID" value="KAG7164267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTY9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01438">
        <property type="entry name" value="tankyrase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000009">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000011">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000021">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000356">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="363"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="396"/>
            <end position="428"/>
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            <end position="523"/>
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    </feature>
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            <begin position="524"/>
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    </feature>
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        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
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        <location>
            <begin position="624"/>
            <end position="656"/>
        </location>
    </feature>
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        <location>
            <begin position="657"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="690"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="802"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="6">
        <location>
            <begin position="874"/>
            <end position="1071"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7164267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1081" mass="117930" checksum="7500BCFB388FC871" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JU64</accession>
    <name>A0A8J5JU64_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JU64"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="132"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="500" mass="56265" checksum="C9C69F24E8EB36CA" modified="2022-05-25" version="1">MANSVSDIDNMSPAIHPVAEPPTFAIPTVMKYNIPKETEFNHAYEVVVALELEYKNIKFSVKPNLVGDLILSPQDHNTAKILSEASNLNGKTIKIIPLDPEEKTTRMVLLRYPLKLPVEVIIKHAKSDQGSALCYESRQSTDKASGHQGDSPRGETQGRNHHDSQVPKLWKETSRLEHIMPREERADESCNGKNSTTKHNRSTSKHIRVGSTATENSQPNTHSAPTVRGFLSCTSPTRLQDKIEDTGTKSVHVRNHDKSVDSTTAASELYNSKSTEQSCIGGEQNIAWDTATAPPPSGAHPTEYTPACQSASGIHRRTNKTDDHYYDSDCFYNNKEQDTNTENIIKAIMTQLAEKMQEDQSPKNSTSGTDDTLESDIRQEEELAIRSITQNRETSGPLQQIPRNRTTNTDRQQTYDHRQERHHPEERRKNSLDTSQNKRNYTSCSSLRAGAQERATNEHTIPNGRGGERLNYERREQLQHQRRGDNDRIAPPPGHLRITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUH9</accession>
    <name>A0A8J5JUH9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Patched domain-containing protein 3-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Ptchd3-L1</name>
        <name evidence="11" type="ORF">Hamer_G004087</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUH9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF92">
        <property type="entry name" value="PATCHED-RELATED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="10">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="596"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="680"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="701"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7159459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="743" mass="83309" checksum="9ADA67645D4D3174" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVW0</accession>
    <name>A0A8J5JVW0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger protein 827-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Znf827-L1</name>
        <name evidence="3" type="ORF">Hamer_G007270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVW0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7165437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="77" mass="9205" checksum="74413E2987DC26DF" modified="2022-05-25" version="1">MSEAERLAWVRSLGGGQTWTCPVCHKVFGMRYYYERHLKCHQAQKDHQCPYCSFRASYKWNVKSHVRNKHRDKPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWD8</accession>
    <name>A0A8J5JWD8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ficolin-1-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Fcn1-L8</name>
        <name evidence="2" type="ORF">Hamer_G029562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027015">
        <property type="protein sequence ID" value="KAG7162805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWD8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="211" mass="24399" checksum="453791F26A7BB11D" modified="2022-05-25" version="1">MKVFVSSPAGVRVYCEVHEGQSWTVFLARHHQSTQENFTRSWQDYKKGFGDPEGEHWLGNENLHTLTGGETRYRLRVEATNLQGEQRYGEWRVFRVAPEDNRYRLTVEQYSSSSTLGDGLNYHNGQSFTTVDRDHDTNPSINCAVHHGGGGWWWRWGWRWGWVCGDVNPTGPLHLSDLHQDPWEVMSWVSFTPGDGRWVKLSSLTMMVIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWF0</accession>
    <name>A0A8J5JWF0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative vegetative cell wall protein gp1-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G020700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026991">
        <property type="protein sequence ID" value="KAG7162820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWF0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="545" mass="61131" checksum="A18DDB52E387E22F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JY17</accession>
    <name>A0A8J5JY17_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neuronal acetylcholine receptor subunit alpha-9-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Chrna9-L2</name>
        <name evidence="4" type="ORF">Hamer_G022853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029263">
        <property type="protein sequence ID" value="KAG7161484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JY17"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="3">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7161484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="362" mass="39958" checksum="5CF4D371ABCA7C3E" modified="2022-05-25" version="1" fragment="single">MVFSLPAESGEKIGLGINSMLAMMVFLMAMTENLPPTENLPLAGVYYGACISMITMNIALSVTVLNLNVMGLRGYQVPDVLKIVTLFVAKVIVVRIPIIVRESWGLEDNVTVTVTPEQNINETINVDGSLVKVFTVQPQKPSEFPKKEPEKKHLDDDLDSLQLTDPFQRKAIAALESINRILTREETERNKVNKKSNLVEQWKFVSRVMDRTLFISFTIITFSFNVAILTSSPFRQSFAYCPLGENGECDDLTWQDITELTNHAASGTHFAQGDQEDSPWGGAHGAASSAHLAAEVAYDGFDDPLPQHDHGGGTYSTMPRKQAHGALASSAIIELHKVENQVEHKDQVEDHSSTLITRGHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JY37</accession>
    <name>A0A8J5JY37_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G013675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022272">
        <property type="protein sequence ID" value="KAG7166650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JY37"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14318">
        <property type="entry name" value="UBA_Cbl_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="687"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="766"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="814"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="875"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="913"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="950"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1070" mass="114856" checksum="536ED7E559321476" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYZ0</accession>
    <name>A0A8J5JYZ0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="17">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Pgant7-L</name>
        <name evidence="20" type="ORF">Hamer_G014432</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Golgi apparatus membrane</location>
            <topology evidence="2 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="17"/>
    <dbReference type="EMBL" id="JAHLQT010026055">
        <property type="protein sequence ID" value="KAG7163975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYZ0"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23437">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000019">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000053">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF68">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 17" id="KW-0430">Lectin</keyword>
    <keyword evidence="16 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="19">
        <location>
            <begin position="493"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG7163975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="619" mass="69924" checksum="B668104FC2F6ACC9" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZ95</accession>
    <name>A0A8J5JZ95_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylinositol transfer protein alpha isoform-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PITPNA-L1</name>
        <name evidence="3" type="ORF">Hamer_G014286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025553">
        <property type="protein sequence ID" value="KAG7164155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZ95"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:phosphatidylcholine transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF11">
        <property type="entry name" value="VIBRATOR, ISOFORM B"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol transfer protein N-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7164155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="194" mass="22099" checksum="E65E3A673031DB31" modified="2022-05-25" version="1">MEGVLDVPGDMVDSNLHLPLIIIVVVAFLLFTHIVWAHELTGDKLRLREVVPIDISNDPVKTADYKPDEDPSKFKSVKTGRGPLQGPEWWKKCDPVMTCYKLVTCEFKWFGLQTRVEKFIQDVERRLFTNFHRLRGQMPCFLKSFMANRVFQVRVGTSLSRSVHQMEGIPQGSFECDPNAIAINGVTQYLSSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K070</accession>
    <name>A0A8J5K070_HOMAM</name>
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        <submittedName>
            <fullName evidence="7">Solute carrier family 46 member 3-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Slc46A3-L7</name>
        <name evidence="7" type="ORF">Hamer_G023927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025664">
        <property type="protein sequence ID" value="KAG7164098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="120"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="151"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="574"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="702"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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            <end position="790"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
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        <location>
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            <end position="1562"/>
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    </feature>
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        <location>
            <begin position="1744"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1752"/>
            <end position="1761"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7164098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1800" mass="197904" checksum="29D868126FFF0CDF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K197</accession>
    <name>A0A8J5K197_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FACT complex subunit SSRP1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ssrp1-L2</name>
        <name evidence="2" type="ORF">Hamer_G023593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023937">
        <property type="protein sequence ID" value="KAG7165693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="285"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
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            <end position="121"/>
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    </feature>
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        </location>
    </feature>
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        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="349" mass="38876" checksum="43E94ACDAA821DE0" modified="2022-05-25" version="1" fragment="single">MEIPTKNKSGESTGVSRSGRVRKKSSKLADFESPDEIDTRFKRKTDRPQKSPKVMKLGHPMGADIYDDSDSFMDDDVIDVKDEPLEVDDWGENEEVDDDMCDDGDDREDATDPLQVDDDSTDMPRESSNYSLAQSLYFSEKQGKKNIMLKDGQVVRRKKAQRKDKGETLRATEVSVDRKRRRPLSAKMEDLLYVWILELRKNNVPVIRKSGPPVCCPPGGKRRAPSDGLDWPKSWEAVDWLTMKRCLEAVAVVQPVGPTGNPAALATVRDGSEDNWKRRAKRLAAKGNQKGSMISTGKAAKQSQNTVRSNLINKGGVKPQQVIRTTSKQPDVGQSAPAPTQKTHVATPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2Y2</accession>
    <name>A0A8J5K2Y2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G005578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7166469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6363430at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="727"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="878"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="899"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="932" mass="100702" checksum="EFFBAF7246502887" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K331</accession>
    <name>A0A8J5K331_HOMAM</name>
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        <submittedName>
            <fullName evidence="10">G-protein coupled receptor Mth-like 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mthl3-L</name>
        <name evidence="10" type="ORF">Hamer_G013304</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Mth subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015640">
        <property type="protein sequence ID" value="KAG7169682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K331"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052808">
        <property type="entry name" value="GPCR_Mth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036272">
        <property type="entry name" value="Methuselah_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63877">
        <property type="entry name" value="Methuselah ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035326490" evidence="8">
        <location>
            <begin position="23"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
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            <begin position="273"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7169682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="559" mass="64181" checksum="67244B107673C0B9" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K532</accession>
    <name>A0A8J5K532_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G012263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K532"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035221358" evidence="2">
        <location>
            <begin position="38"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="86" mass="8883" checksum="F2546CE936DEB614" modified="2022-05-25" version="1">MAVSVTVRRLASQRLTAAPSSRLLLLLLLLGATLCAAQMTAGGAGTRTAARPGDQGTERLKTDKRWQGGSCRGSGISLREEDGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K597</accession>
    <name>A0A8J5K597_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020657">
        <property type="protein sequence ID" value="KAG7168101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K597"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="251" mass="28880" checksum="CA602BFADA5A960B" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSEPNCSHSGKRENNSHIDCGCPREKKIPVFELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5L7</accession>
    <name>A0A8J5K5L7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein kinase receptor</fullName>
            <ecNumber evidence="14">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BMPR2-L</name>
        <name evidence="17" type="ORF">Hamer_G007228</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44880"/>
            <dbReference type="Rhea" id="RHEA-COMP:11024"/>
            <dbReference type="Rhea" id="RHEA-COMP:11025"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="14"/>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5L7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005024">
        <property type="term" value="F:transforming growth factor beta receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF100">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00653">
        <property type="entry name" value="ACTIVIN2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="191"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="697"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="749"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="849"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="900"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1022"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="698"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="849"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="910"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="930"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1022"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7165399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1057" mass="116745" checksum="08756110A0575A22" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5S9</accession>
    <name>A0A8J5K5S9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G026858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024230">
        <property type="protein sequence ID" value="KAG7165504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5S9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7165504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="923" mass="99653" checksum="CB5763F3201BDFEE" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K632</accession>
    <name>A0A8J5K632_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger CCHC domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Zcchc2-L</name>
        <name evidence="4" type="ORF">Hamer_G013441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="PHAT_Smg/ZCCHC2-like"/>
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        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042344">
        <property type="entry name" value="ZCCHC14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16195">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16195:SF16">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26034">
        <property type="entry name" value="PHAT_SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="1642"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="425"/>
            <end position="554"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="641"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="707"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="759"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1246"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1415"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <end position="443"/>
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            <end position="511"/>
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            <end position="535"/>
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            <end position="554"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
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            <end position="1297"/>
        </location>
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        <location>
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            <end position="1314"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1321"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1499"/>
            <end position="1516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7170625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1672" mass="173238" checksum="4D2C3A7C0B69BD5D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7C3</accession>
    <name>A0A8J5K7C3_HOMAM</name>
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        <recommendedName>
            <fullName evidence="3">NADH:ubiquinone reductase (H(+)-translocating)</fullName>
            <ecNumber evidence="3">7.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NADH dehydrogenase subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ND5-L10</name>
        <name evidence="11" type="ORF">Hamer_G028596</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="3"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
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        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
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    </dbReference>
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        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="NADHDHGNASE5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
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            <end position="42"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="231"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="318"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="463"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="489"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="739"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="10">
        <location>
            <begin position="95"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="10">
        <location>
            <begin position="516"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7168794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="837" mass="92782" checksum="C789FE0EE92E571D" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K809</accession>
    <name>A0A8J5K809_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein 6-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Mfsd6-L9</name>
        <name evidence="9" type="ORF">Hamer_G016883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020459">
        <property type="protein sequence ID" value="KAG7168238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K809"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="13"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7168238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="257" mass="27938" checksum="A93DDD8CB27D94A4" modified="2022-05-25" version="1">MMLLELNFKLPTQSLTKEIISHLYNPKVVIFLCAMLLAGVVMGYLETFIYRYLGSLGGSPLLLSLTVAVVAPLNFFLTLASSFLVNLLGHAALISLGLFVISFRMFVYSMLVNPWWALPLEMLDALCSGLLTNVAIMYCTVLFSSKSITSSRGIISALNFGLGQLLGNLVGTEIREVMGDRATLQVFGGAAFVSAVLYGAAYLFITRQSLFTHSSTQGSNSPTETTNNHGTDNKSFEDTIEMEPSDSGTTENTREVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KAE6</accession>
    <name>A0A8J5KAE6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allatostatin A-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">AstA-L2</name>
        <name evidence="2" type="ORF">Hamer_G028533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018559">
        <property type="protein sequence ID" value="KAG7169063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KAE6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010276">
        <property type="entry name" value="Allatostatin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05953">
        <property type="entry name" value="Allatostatin"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08261">
        <property type="entry name" value="Carcinustatin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="496" mass="55064" checksum="732076E21603AAA2" modified="2022-05-25" version="1">MVLQYYDTEPSYLYDYGKRHSNYGFGLGKRTPGYAFGLGKREGLYSLGLDKRSDLYSFGLGKKSGSYNFGLGKRSVGDLPEVSKVEDGASPRTKRDVSITEDTLEDKRAKYSFGIGKRESSKNKRSKLYGFGLGKRDSGEERREDDDMENRTQQYSFGLGKQDPDMEIEKRPRNYAFGLGKRESDEDSDKRSQMYSFGLGKRDPDMDMDKRPRDYAFGLGKRASSDEDDEERYYAYEQGKRPTAYSFGLGKRAFSETDDYDNVNDNDDGDDELELSDLEQYSDDLKRATSYGFGLGKRSDAPDSGFGRRSYDFGLGKRAGRYAFGLGKRTGPYAFGLGKRTGPYAFGLGKRTGPYAFGLGKRVGPYAFGLGKKAGHYAFGLGKRAGPYAFGLGKRSGPYAFGLGKRADPYAFGLGKKAGQYSFGLGKRSGPYSFGLGKRSDSDSDQYTLGRRSGVYSFGLGKRAGPYSFGLGKREVSDDDHDEDEQDIGVEEEMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KBP0</accession>
    <name>A0A8J5KBP0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Aminopeptidase</fullName>
            <ecNumber evidence="20">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">ENPEP-L2</name>
        <name evidence="25" type="ORF">Hamer_G012231</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="18 20">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 20">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="20"/>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KBP0"/>
    <dbReference type="OrthoDB" id="510539at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000003">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000012">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000016">
        <property type="entry name" value="Glutamyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF276">
        <property type="entry name" value="GLUTAMYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20 25" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 20" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 20" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10 18 20" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="24">
        <location>
            <begin position="116"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="22">
        <location>
            <begin position="338"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="23">
        <location>
            <begin position="638"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="43"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="19">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAG7170009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="979" mass="111775" checksum="2656EE5EF94A1A64" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KCC5</accession>
    <name>A0A8J5KCC5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-iminobutanoate/2-iminopropanoate deaminase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RIDA-L</name>
        <name evidence="2" type="ORF">Hamer_G016094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014436">
        <property type="protein sequence ID" value="KAG7170291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KCC5"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="136" mass="14452" checksum="88D420D02401D9AC" modified="2022-05-25" version="1">MASKILRKVISTPKAPAAIGPYSQAVQAGNTLYVSGQLGMDPQTMNLVSGDVVEQTKTALTNMGHILEAAGCTYKHVVKTTVLLADINDFVKVNEVYSTFFSEAVPARAAYQVANLPKGGRVEIEAIAVVGELDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KDH5</accession>
    <name>A0A8J5KDH5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDK5 regulatory subunit-associated protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Cdk5rap2-L</name>
        <name evidence="7" type="ORF">Hamer_G018358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7167934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000242">
        <property type="term" value="C:pericentriolar material"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046600">
        <property type="term" value="P:negative regulation of centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042791">
        <property type="entry name" value="CDK5RAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46930">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46930:SF1">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="6">
        <location>
            <begin position="101"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1162"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1285"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1329"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1414"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1830"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1866"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="102"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="420"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="716"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="889"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1383"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1469"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1577"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1688"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="2018"/>
            <end position="2059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1162"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1183"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1336"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1360"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1414"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1830"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1884"/>
            <end position="1919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7167934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2086" mass="234692" checksum="8CBE356266DEB86E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KDH9</accession>
    <name>A0A8J5KDH9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase CCNB1IP1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Ccnb1ip1-L</name>
        <name evidence="3" type="ORF">Hamer_G018985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014098">
        <property type="protein sequence ID" value="KAG7170493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KDH9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042448">
        <property type="entry name" value="CCNB1IP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="363" mass="41455" checksum="007D90A7547DDC86" modified="2022-05-25" version="1">MSDNQLLCNFRSCRRPLDDFAWVTFCSHIFCDNHGKPLTQTPCECSACGARLVDKTDIHRVDLEPSEQFKSMVLAGLRPSTVMEVCHRALAFWSHQMDQELNHQRHLNQKLRERAHHVHTYYEQEMRARDEHLNLLTGQLGALQRDHDKCNKQKQSLNERLSEKTRQYHKLQDLYDCLRKRTGQIRARSCSPPPGTSTAISTTCLSMVQMDGAPQPPNMLPPTRLALIEGVPPTGSLSPRKPQSYQQQQQQQQQQHQPPAMNLSQRPPDYHHPPLQPPLMAYGPPRYPHQQEDQRTAPGTNRNLPGRHHQQLPSVRYPAATPLTRDSQLLLPTPKISREFTFQPSIFTEPGDPSDLHGDGAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KFC1</accession>
    <name>A0A8J5KFC1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Obg-like ATPase 1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ola1-L1</name>
        <name evidence="7" type="ORF">Hamer_G013882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012946">
        <property type="protein sequence ID" value="KAG7171089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KFC1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000029">
        <property type="entry name" value="Obg-like ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YchF C-terminal" evidence="6">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7171089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="104" mass="11795" checksum="E301D3CA9B52C8AB" modified="2022-05-25" version="1">MSSLDKIIIQGYKALQLMYFFTAGPDECKAWTIQAQAPQAAGKIHTDFEKGFVMAEVMKYNDFKEEGSEAACKASGKYHQRGRVHYVRRRHNILQVPTGGLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJE5</accession>
    <name>A0A8J5MJE5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G009350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJE5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="42" mass="4566" checksum="A9824328800E19C8" modified="2022-05-25" version="1">MPPKDPEAEKLKKELQDAIAKVQVVVVVVVEIGNGCGMKYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJT4</accession>
    <name>A0A8J5MJT4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Midasin-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MDN1-L8</name>
        <name evidence="2" type="ORF">Hamer_G020383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045754">
        <property type="protein sequence ID" value="KAG7154054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="1118"/>
        </location>
    </feature>
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            <end position="1226"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="93"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="112"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </location>
    </feature>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="708"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="970"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="1047"/>
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            <begin position="1080"/>
            <end position="1118"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <begin position="1205"/>
            <end position="1214"/>
        </location>
    </feature>
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        <location>
            <begin position="1215"/>
            <end position="1226"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1325" mass="153342" checksum="C5D337644F4A6A39" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKM5</accession>
    <name>A0A8J5MKM5_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031647</name>
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    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043396">
        <property type="protein sequence ID" value="KAG7154924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="121" mass="13578" checksum="E567F1FB7EE802B8" modified="2022-05-25" version="1">MVKQNTRPMTSSPVVCLIGETEAIHFTPHSESFLHSTPHSQSFPHSNTSVSPSLTPIHHSETFPHSYTTQSLKSFLIYENITMSFPRSYTTLHKSFPPFLHNTEVLPSMLHNTACPSSVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MM64</accession>
    <name>A0A8J5MM64_HOMAM</name>
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        <submittedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein 4C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Lrrc4c-L</name>
        <name evidence="3" type="ORF">Hamer_G006498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Multicrustacea</taxon>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MM64"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="173" mass="19692" checksum="E3A1F50671128026" modified="2022-05-25" version="1">MTRNDMAIRVEDFTFSFSILTTLPEDLLPWEHLRQVSLVYNQWNCDCNMKWVKSSPLMDLVGVRMVCSQPPRLRGRHLKGVDEKDLLCGHEIASSRKAFGFLAGLMAVGIVASLGTVALLVYWRRGWLCRRPAGVYTNIERTPKTITVADELPWDNPEFQSGNENSQDYSVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMH5</accession>
    <name>A0A8J5MMH5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Dctn4-L</name>
        <name evidence="16" type="ORF">Hamer_G024049</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="14">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038600">
        <property type="protein sequence ID" value="KAG7156829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMH5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7156829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="314" mass="35654" checksum="9337B63A8C9A14B1" modified="2022-05-25" version="1">MFMWCSKTYHRYLFLPSLPEAEMWELCISRATGGWSEQDNEHYKYLQSLLEHYRSVAQQEKLDRERKRFSHRKSAYLSLTDKYSLPSLLGRKSLTPLSPYAPKGDSSQSLDMTASEATAEVEGLPDEIFTEEVVLSSVTDMEQRMASPEWQPEKTSDLYPLHKHILVKRSLRCRHCEHNLSKPEYNPSSIKFKIQLGAFMVRVVDIPPEKTDLTPSADVALPQGQVILAARDDTAEYDDQDSISSYKDDPLVVAWRRANKVGINLLVTPKANVSRAKVGFVLRYDYTNTVATASESRTVTLNIPVMVDVGTVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MN97</accession>
    <name>A0A8J5MN97_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Proteasome subunit alpha type-2-like 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Psma2-L19</name>
        <name evidence="2" type="ORF">Hamer_G026388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036943">
        <property type="protein sequence ID" value="KAG7157778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MN97"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035197742" evidence="1">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="124" mass="13149" checksum="C5C2F99D13488155" modified="2022-05-25" version="1" fragment="single">MVSLGCRVVMVVATAISAVPVFSKDAGGIVEQVGVLVNQVVEHHLTGCHLVLITTTQHSHVFASIIRHMSVGVAAGVVVDAGWVLSQDQLAKDHLLQGLWGDERTTCRGLILDLTTSNSTDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MP57</accession>
    <name>A0A8J5MP57_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G008914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MP57"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035165633" evidence="2">
        <location>
            <begin position="19"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="132" mass="13390" checksum="D66F895389FF10BC" modified="2022-05-25" version="1">MWVAALALVATLAVTGSAEPLPEADPGFHRGFGGFGGRSHGGFGGYGGHGGYRGKRSAEAEALADPEADPSDGHLSYGGYSGYGGFQGIGRQHHYGKRSADADPEPGFSRYGGFGGHGGGFGGFSRYGGYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPX2</accession>
    <name>A0A8J5MPX2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pro-resilin-like 90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G016555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPX2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7159172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="161" mass="17927" checksum="1C253E44DE3BBD52" modified="2022-05-25" version="1">MAVARPQNHPRQYYGSPGSDFVLVLCVVTMPVARPQNHPSEYYGSPVSNFVLVLCAATMTVARPQNRPNEYYSSTGPDTSAQYNFNWQVKDDPSGNDFGHEESRDGDNTQGSYYVLLPDGRLQRVTYTVNGNSGYVAEVTYEGEAQFPTYQSSYTPAPRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQQ8</accession>
    <name>A0A8J5MQQ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative CENP-B N-terminal DNA-binding domain-containing protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G027077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031905">
        <property type="protein sequence ID" value="KAG7159847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQQ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="90" mass="10454" checksum="7020638A5EAEC447" modified="2022-05-25" version="1">MAIEKVNKESPKPKCDYCKGVKKRKYTLEMKWEMLEMIKSGTRTCEIMRRFNCPESTICSLKKNKEALTASVNVFSRFSSSNRIFSDTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQS8</accession>
    <name>A0A8J5MQS8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BTB/POZ domain-containing protein KCTD16-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">KCTD16-L</name>
        <name evidence="12" type="ORF">Hamer_G021284</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Postsynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Presynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031318">
        <property type="protein sequence ID" value="KAG7160324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQS8"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18367">
        <property type="entry name" value="BTB_POZ_KCTD8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22204">
        <property type="entry name" value="H1_KCTD12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057093">
        <property type="entry name" value="H1_KCTD8_12_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23110">
        <property type="entry name" value="H1_KCTD8_12_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="BTB" evidence="11">
        <location>
            <begin position="44"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7160324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="281" mass="31312" checksum="27473EE3E4DBA46A" modified="2022-05-25" version="1">MATNGAATNSSSSSASSNSGQPSTEPQLQQTGPGMNAIVQVFPPIVELNVGGVFYTTALTTLQREPDSLLGQMFSGKTKTPVLRDSKGKFFIDRDGVLFRYILDFLRNQKLVLPENFSERERLKKEADFFQLQDMIDSLTLPKSLSPVDPAYSVRTSVGTITVSYRGTFAFGRDGLADVKFRKLSRILVCGRVTLCREVFGETLNESRDPDRGATDRYTARFFLKHTFLEQAFDMLVLAGYKCCGSCGSSTAGGIMVDKKPGMDNEEDRWNHYNEFVWVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR89</accession>
    <name>A0A8J5MR89_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030308">
        <property type="protein sequence ID" value="KAG7161033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR89"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="291" mass="31828" checksum="9DC221D75FD7D244" modified="2022-05-25" version="1" fragment="single">AKLKFLLISGGLLNRGHQHYYPNTTTTITTTTVTNSTTSTTKMSRDYPSTCKSMMDLTGRSGDSEQHQRLHKARSVWDVGGKPAVRRRRTTETFRPPDPVVEPRARPVSLPVTSPVRPKRVSAIQWAEGVGREETDKETRGSFLTPSSAGRPHRYSSSSVTSTPSTPAILSSSSAGDGVESVMFRGEGNLLEAQSMMSLSRPYRVSNGSDDEPRGFRKKSASALHALKNLSRSTPAMSPSASPRHSDSEGPPRVSKGTKKFMRHFADAPASEWVLNCECCVVLWLVGRHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MS69</accession>
    <name>A0A8J5MS69_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Relaxin receptor 2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Rxfp2-L2</name>
        <name evidence="3" type="ORF">Hamer_G019916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028706">
        <property type="protein sequence ID" value="KAG7161903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MS69"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="157" mass="18217" checksum="BDA1F2F7EABD4F95" modified="2022-05-25" version="1" fragment="single">NIKGSEVFSLDAAVMSQYSTLTTLYLSKNFIQEIHHKNCFGLRTLLRLFLDRNRLYRVDLTCFIHTPALQELNLAHNELTLDNQSFPHLPNLTNLKLEDLELLDISEDHFSFLSKLKIVYFHTFRYCSYVPKVPQCLPNFDGKKPLSCSMIFSASQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSK1</accession>
    <name>A0A8J5MSK1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Glutamate receptor 4-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Gria4-L6</name>
        <name evidence="2" type="ORF">Hamer_G023321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028469">
        <property type="protein sequence ID" value="KAG7161974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSK1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035146433" evidence="1">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="216" mass="24750" checksum="0F00BE9EEE626BEA" modified="2022-05-25" version="1" fragment="single">MARYLITLATIFLIASNVLNLSIQKTCALVGGTEGFERLVDNPDLNNLHQGNISFIKTQVKREVLTKRTITTSKKASDITQLQDSVIHPVVLCTLTRTVRRVCPWDLNQTEDSLDSLGRLLKTVVVQEMTHCDLVLAYDHHYHPLLHYILTLGNVKQVWRVRGPGDLLQVSWSSNRCRGYLLIISHSEHLANFTNTYRDAWDYHGRYSYTTYTTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSM5</accession>
    <name>A0A8J5MSM5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G024829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027435">
        <property type="protein sequence ID" value="KAG7162695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSM5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="183" mass="19740" checksum="467E384A93F72D09" modified="2022-05-25" version="1" fragment="single">SWCYCSVWSLQAGATVVCGLQKLVLLWCVVYRAGATVSVWSELVLLWCVVYRGWCTAVCGLEAGATVVCGLQAGATVVCGLLQSWSYCSVWSRLELLPVCGLQRLEPCLAGATVVCGLQAGATVVCGLELGTVVCSLQAGAAQCVVSGGWSYWCVVYRGWLHCGVWSRLELLWCVVYRGWCYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MT26</accession>
    <name>A0A8J5MT26_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein heavy chain-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Dnah-L12</name>
        <name evidence="2" type="ORF">Hamer_G008056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MT26"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="826" mass="90707" checksum="07F164BB20C4936D" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTD2</accession>
    <name>A0A8J5MTD2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase Hamer_G002765</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Hamer_G002765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTD2"/>
    <dbReference type="OrthoDB" id="206354at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03187">
        <property type="entry name" value="Methyltr_EFM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7163565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="219" mass="25219" checksum="E2BBFF36560C4597" modified="2022-05-25" version="1">MSSSESEDEIMELELSAETMGALMEYYMEQAEREQKLREIEEGDVPDSFEENWNMSQFWYSEETARSLAEECIRTAGNNGSIACVSAPTLYRTLMKMEHSCSVKVLEFDTRFSVYKDDFIFYDFKDPLGVPRKLHEHFDVIVADPPYLSDDCFTKTAITVKFLMKPDATIIVCTGSVMEELAERLLGVKKCQSEIKHENSLSNPFVCFANYNLDDHWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MV08</accession>
    <name>A0A8J5MV08_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Insect cuticle protein-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G007297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
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        <source>
            <strain evidence="4">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7165455.1"/>
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        <property type="term" value="C:chitin-based extracellular matrix"/>
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        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
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        <property type="entry name" value="Insect_cuticle"/>
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    </dbReference>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7165455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="421" mass="48214" checksum="E6D8FE2580C6CF03" modified="2022-05-25" version="1">MAKKDNYDFGFNAGSHFRQEEKGADGMTRGEYGFRTPDGCMHIVSYEADQVGGYRVLGSSKRDCVYAVTRRPIITTRRPITTTRRPITTTRRPITTTRRPIKTTRRPITTTRRPITTTRRAITTTRRPITTTRRPITTTRRPFTTRRPPTTRRPLTTPFISFIPVTSPRPRDPLLVPEVPLVVDNTIVVDNSQGRQLSSPNQTTQRPTVTTTTAKPEKKPEPLYSFGFTTPTHGHTETGLPDGSKKGEYYWDAPDGWRRIVTYEANERGFFPKMRRVRIPTTTPVPPSTTTEEGPIDNPKLGKDLDDDIPTPRGGCPYYFYYNTRINYHWEHCYMNNTKVGEFGNLGSDGYAHKNAYYADATGFHPTLSRTPLNEDQKNVVADYTEGVFIVPKPDEERRETEKRILAWLAENRERIQNPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Unc-13-like 3</fullName>
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        <name evidence="3" type="ORF">Hamer_G017233</name>
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        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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            <taxon>Pleocyemata</taxon>
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            <taxon>Homarus</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1118"/>
            <end position="1238"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7164842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1652" mass="184258" checksum="409906285D6072E6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW53</accession>
    <name>A0A8J5MW53_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-directed DNA polymerase from mobile element jockey-like 13</fullName>
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        <name evidence="3" type="ORF">Hamer_G031288</name>
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        <name type="scientific">Homarus americanus</name>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022232">
        <property type="protein sequence ID" value="KAG7166670.1"/>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="138" mass="15153" checksum="4685F269D803B086" modified="2022-05-25" version="1">MSKDQQFRLPGYQQYSVPKGPNSHGSMILVRATIPSSEVEPVHCGDGVEAQAVRIHLAYDSLVVYNIYKPPTKRLEAGELLTQATQELVLVAGDFNAHHPTINSTTRMSLDGRHLVELLTDVPEITLINTGEPTHILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXM5</accession>
    <name>A0A8J5MXM5_HOMAM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXM5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="38" mass="4045" checksum="F9050A07E8CE83D9" modified="2022-05-25" version="1">MAVVGDGGSVVMVVVVGDGVVMVVVCQHRQLWHPGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYF1</accession>
    <name>A0A8J5MYF1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYF1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="51618" checksum="DD94EFF254B930DD" modified="2022-05-25" version="1" fragment="single">ASKVKLFNVVRSLLFGDSVDVGLREDHGEASQVNVAESRSVIDELLLLEPQIKLKEVGIPRAARLMPMRSWTRSPLNGVSKFSTYTCSFCGKPGHKAEFCWTRLQLNTGKPAMIVTEEANTSPVGVMAGLSKADSMPIALVSTKGEPRESAVSVLTSRDFDLFQEGFAKDPDVGTFRPFLSQGTVEVDGAETPVTILRDSGCLQTLIKEGVVAARKTDKYVVLGSLWGQGVASLVLVRVKSSCFSGITNVACVHELPVAGVDLILGNDLAGGQMGNVTPPPVLRERPESAAELQQLEDDMPDVFPLCAVTRSMSMTNDHYVTPDVDDSLSLEGLFANPIASQDISSAVNAVTGRVAFIAAQEQDDSLQLLFDQINCSGAEEVQQLCAIADTGAQVCLAGLQHVRALGTRPTPPGRSPHRREPHCRRGREHRREQGVSSHRWTCHNQDAPVFCGRCPVSVASKVEGSHTAATSSISLSKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N069</accession>
    <name>A0A8J5N069_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aryl hydrocarbon receptor nuclear translocator-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Arnt-L1</name>
        <name evidence="8" type="ORF">Hamer_G013231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015640">
        <property type="protein sequence ID" value="KAG7169627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N069"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050933">
        <property type="entry name" value="Circadian_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23042">
        <property type="entry name" value="CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="230"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="496"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7169627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="553" mass="60275" checksum="A06D20F8AA6FC8E9" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1S1</accession>
    <name>A0A8J5N1S1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cell surface glycoprotein 1-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">olpB-L7</name>
        <name evidence="14" type="ORF">Hamer_G014776</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1S1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001973">
        <property type="term" value="P:G protein-coupled adenosine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="514"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="68"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="675"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="711"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="929"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="71"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="186"/>
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        </location>
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        </location>
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            <position position="1049"/>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Zimin A.V."/>
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                <person name="Kohn A.B."/>
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                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
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                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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</entry>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Greenwood S.J."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5N630_HOMAM</name>
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            <fullName evidence="13">Glycine receptor subunit beta-like 6</fullName>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Timp W."/>
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                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008626">
        <property type="protein sequence ID" value="KAG7173902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N630"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000065">
        <property type="entry name" value="Transmembrane protease serine 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="12">
        <location>
            <begin position="261"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7173902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="435" mass="49320" checksum="583CD797585856E8" modified="2022-05-25" version="1">MVEKVGDVWTWYDSITNITKAVLPVQEHLNYPIGRQTWDIKDPVCGQESGKRQLTLSPCTAGEFTCTDGTCISFARRCDLKFDCGDKTDESFCDIVNFPGDYRSKLPPRPVSDLSLPISVNVSMDTINIDTTTMLISVSYNLHEIYLGWGSSHLTVEVYRGDTNPVSTTRKYSTVFTCNFDLVLYPFDIQTCSMQLQIQSASSEYLIFNSNDSYAQYLGQKFLIEYGIGLIDLQVDNAMQYSEMKVRIELIRRYGYAMLNIYIPSLTLLIISYVTLFFRPTIFEVRVMTALTALLVLATLFTQVSTSLPKTSYFKMVDIWLLFCIVLIFFIIIFHTIIDFHVDYSNTGAPLSSKGWVGTSQRSSGSNIVKVTPVGGNTKSGDEDMNNLSINFLKVRFDAKFYINLSKLTMFLVFFVFNITYWGTLAVGSGLVYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6A4</accession>
    <name>A0A8J5N6A4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrator complex subunit 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Ints5-L</name>
        <name evidence="4" type="ORF">Hamer_G003274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6A4"/>
    <dbReference type="OrthoDB" id="69088at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="INTS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029444">
        <property type="entry name" value="INTS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029445">
        <property type="entry name" value="INTS5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31697">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31697:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14838">
        <property type="entry name" value="INTS5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14837">
        <property type="entry name" value="INTS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 5 N-terminal" evidence="2">
        <location>
            <begin position="56"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 5 C-terminal" evidence="3">
        <location>
            <begin position="250"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7174335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="954" mass="102625" checksum="1ABF6C4387EC9DBA" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6D2</accession>
    <name>A0A8J5N6D2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tesmin/TSO1-like CXC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G024956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007649">
        <property type="protein sequence ID" value="KAG7174471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6D2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF1">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29304" checksum="56054D359716E6DB" modified="2022-05-25" version="1">MDIVKAAIKASQHQLTTLIGEDTDLLILLLYYAEANNRGLYFRSDKSTVPKVYNISEMKQVLGSDMCSQLLFIHAFTGCDTTSRIFSVGKKSAFQKLVNGEWTIQTCANAFLLPNQANSVIEDLGSKAMAVLFGGKSTDSLASLRYNLLIKKIVSAKSFVTPERLPPTKPSTKYHSFRVFYQIMVWTGKESDMNAVDWGWKLEDNQFVPVMTKKTAVPESLLQMVHCNCTTACRTRCSCSRYGLPCTPACGPCQIENCENPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N720</accession>
    <name>A0A8J5N720_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Titin-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Ttn-L1</name>
        <name evidence="4" type="ORF">Hamer_G003282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N720"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="803"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="661"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
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        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
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        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7174343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="885" mass="94645" checksum="5243122DFCDA7A58" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N740</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
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        <lineage>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174294.1"/>
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    </dbReference>
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            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7174294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="320" mass="36612" checksum="DB4CDACCEC90DFC2" modified="2022-05-25" version="1">MEHKAVETSLGKGNLARKNEYLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGHGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERREGMIVNDSSLVLKKFSVNLRIWQRHHEMLLCRDCIEEAQCSNHTDVPQSVSSSVRSAVLPSVQPPIYLFIRPFSRPFIRSPAHLSVKPFTRQSIPKTILPLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7C9</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">Hamer_G026497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008311">
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="96" mass="10925" checksum="9CE2BC48FD0C0543" modified="2022-05-25" version="1" fragment="single">MLIDLSIITRNLFSGKKKKKKDKFLIEDRSEEVAAGTTIDSTEKSPKKLKMKKKRAFEEVAMKVEPEDTEQLDSCIITKPKKKKKKKKTKVAGNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N984</accession>
    <name>A0A8J5N984_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ring canal kelch-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">kel-L</name>
        <name evidence="6" type="ORF">Hamer_G001489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="UniPathway" id="UPA00143"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF466">
        <property type="entry name" value="RING CANAL KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="29"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="BACK" evidence="5">
        <location>
            <begin position="145"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7175407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="434" mass="48368" checksum="834F5900B99E0476" modified="2022-05-25" version="1">MLNHDKELRPTTTKALVSAPRGLGGLVGLTCFFIGDGRRRPDPQGSRRGNRNYTKLPAQYRVCCQVQMYEKTRCGFEESRQERIVLQDIDGSALQLLIDYVYTAEVLVTEENVQVLLPAANLLQLTDVRDACCDFLQSQLHPTNCLGIRAFADLHGCLELLSIAESYVEQHFTEVVECEEFLSLTSQQVIKLISSDRLTTPSEEKVFECVMSWVSGDLTNREQYLAELMEYVRKDYLIEAMKFHLLKGEQKALFKSPRTKPRQPVGLPKVLLVVGGQAPKAIRSVECYDFKDERWFPVAEMPTRRCSMEARRSTLGVATLNSCIYAVGGFDGSTGLNSAEMYDSKAYEWRMIAPMSTRRSSVGVGVVSGLLYAMEPRVIALNGLLYVVGGDDGTSNLASVEVFNPKTDVWTLLPAHMGIGRSYAGVAIIDKPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAG4</accession>
    <name>A0A8J5NAG4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G009942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAG4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="99" mass="11047" checksum="5572BE8637308391" modified="2022-05-25" version="1">MSANHISSSMGEMNTGKRAVVDVSKDQFGHPLVNQEVQQLDTTNNELLLENVEIIESLDVGNRVTGMVEEEEMDQQGQQNMYMSQPQNHLEKCVGVLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBE3</accession>
    <name>A0A8J5NBE3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G009238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBE3"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="335" mass="38643" checksum="68B69E53B6371E85" modified="2022-05-25" version="1">MAAKLSNSWSFFSGRRNQNKDYLNQDYQPNTPSSRVNLQKRFSHEQEKEGRWRRGPLPPPPTHNHGHTSDYQQWHHHEAKKPSQTNPNSDHVDIGHYSNHYGYPKKSTGNCNEHPKGLPNYKYPQQYHPQHQGHNSRSQSPRTSHTFPRRPLRKLPSGVAPLWNNIQDNVSQLKPQTSKLFHEGGRKMNRALQGVRTSLSSLTQIFRNSTRRRYKLGGETPTRTPGRTPRHTPGKLYSPFDLSTPATPHSYAKGPKRLQNATARRNIYGNENRAMIRTPQRHHNASRGGRQWNQFHSPSQSLQCDVTAVNRGLKDLEYVSSGILHNGKENWTQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NC42</accession>
    <name>A0A8J5NC42_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Heparan sulfate 2-O-sulfotransferase 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HS2ST1-L2</name>
        <name evidence="13" type="ORF">Hamer_G003778</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfotransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NC42"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004394">
        <property type="term" value="F:heparan sulfate 2-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001418">
        <property type="entry name" value="Heparan sulfate 2-o-sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007734">
        <property type="entry name" value="Heparan_SO4_2-O-STrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129:SF17">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7178026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="293" mass="33916" checksum="484E6A742F957D89" modified="2022-05-25" version="1">MTSSRLQASRVVVLFMVGTGSTSFIGLAYDLCSKNKFNVINVNTTKKNPTLSLTDQMRLVYNMSNWEEKKPGIYHGHLAYLDFNRFGVNVQPLYINIIRNPLERLVSHYYFIRYGDDLMPQRVYKKMGDKMTLDECVALQHPDCSTNHLWMQIPFFCGHYAECWIPGSSWALEMAKHNLVQNYFLVGVTEELEDFVAMLEYSLPRLFKGALDLYVSGSKSHIRKTSKKIMPSDETITKLQNTKVWRLENEFYNFALDHFHFLRKKTLVEAGHGGVLVDRGQNFVYGKIKPKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCB2</accession>
    <name>A0A8J5NCB2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U-scoloptoxin(19)-Tl1a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCB2"/>
    <dbReference type="OrthoDB" id="6332063at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035238153" evidence="1">
        <location>
            <begin position="18"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="122" mass="13131" checksum="5273442B865A2C3D" modified="2022-05-25" version="1">MKYQLSVMVVTWAVASAAVPHVYEGNDDHTEPIMFVPELPCAKEGGLCGLASACPPDFRHPEEGLCPAQKDLGAECCFTVPDNIVRCKERGGECVETKLCGRAPRDAQGQCSQGQVCCIFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCL6</accession>
    <name>A0A8J5NCL6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMRFamide-activated amiloride-sensitive sodium channel-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Fana-L</name>
        <name evidence="2" type="ORF">Hamer_G000106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCL6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="183" mass="20342" checksum="434D9F4182383810" modified="2022-05-25" version="1">MFLVFPDIDALCVKRSLVNYAKSPHTSDCGCNVACHEIQYLKSMSIAAWPPGPAKGISDVVTSLGGALSLYLGISLFLLVEVLELLIWLIYNSIMYAQGRYVPSNSRRNSNSRRISVFPEEPPVSTLDNLRYLKSVHGRDGLVEILSSLAPVYDSSFTSSEKHTNQLSDRRLMSTAFDNAFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCR3</accession>
    <name>A0A8J5NCR3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Tba2-L1</name>
        <name evidence="11" type="ORF">Hamer_G008254</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCR3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="9">
        <location>
            <begin position="48"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="10">
        <location>
            <begin position="247"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7177610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="435" mass="48741" checksum="C3664055BE917256" modified="2022-05-25" version="1">MKRECISVHIGQAGVQMGNACWELYCLEHGIQPDGHLAEDAPQEENMYTTFFQETGRGKYVPRAIYVDLEPTVVDVVRTGPYRQLFHPEQLINGKEDAANNYARGHYTIGKEQVDLVLDKMRKMADACSGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLQFTVYPAPQICTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLGIERPSYENLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPVLSVEKAYHEQLSVAEITNACFEPNNQMVKCDPRRGKYMACCLLYRGDVVPKDVNSAIAAIKTKRQIQFVDWCPTGFKVGINYQAPTVIPNGDMAPTQRAVCMISNTTAIAEAWARLNHKYVGEGMEEGEFAEAREDLAALEHDYEEVAQDSNQEGEEDHEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCS9</accession>
    <name>A0A8J5NCS9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome-binding protein 1-like 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Rrbp1-L17</name>
        <name evidence="4" type="ORF">Hamer_G029798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002358">
        <property type="protein sequence ID" value="KAG7177372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCS9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="149"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7177372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="571" mass="66234" checksum="084867D245A67F9D" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDL3</accession>
    <name>A0A8J5NDL3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDL3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="68" mass="7788" checksum="830F6E7C236373B2" modified="2022-05-25" version="1">MRAIVKAPMWTKIENLHMETGLTSLQTRAERLTACFATKLITRARESDIKNGLLRALSLNRDIFNKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDW9</accession>
    <name>A0A8J5NDW9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001548">
        <property type="protein sequence ID" value="KAG7177863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDW9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF10">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="146" mass="16789" checksum="5731422C2E902492" modified="2022-05-25" version="1">MAAKRSYRDAWLNNEDFRPWLSCVEDNPSRAFCKICKREVRAELTAIKRHKTTKMHSVYEASEQQEVQQERIPVHHGNYAANGVAVATVLFACFIAEHNLPFTTADHLVDLMKRMFPDSAIAQDMDMKRTKCTEVVRTLGRCVTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T1Z5</accession>
    <name>A0A8J5T1Z5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T1Z5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19652" checksum="4D0F0815F01B5BB9" modified="2022-05-25" version="1">MFRTKYGKKPPDVKFIKSWMKILETVNVEKGKSSGRLSVSDGTVENIPTAFTRSPRKSVKQASRRLQMPKSTVHKVLQNCMKLHAYKVQIVHQLMPDDRPKREQFANDILNSIDEDNDFLLRVCFSDKATFHVSGTVNKHNVRIWGSENPHVVREHIGYSLKTNVWCTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T2G7</accession>
    <name>A0A8J5T2G7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 33A-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Vps33a-L1</name>
        <name evidence="2" type="ORF">Hamer_G001073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T2G7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="545" mass="61210" checksum="CDFC4BA912D6747B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TDT4</accession>
    <name>A0A8J5TDT4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Caffeoyl-CoA O-methyltransferase 2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">omt6-L1</name>
        <name evidence="5" type="ORF">Hamer_G017842</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007950">
        <property type="protein sequence ID" value="KAG7174106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TDT4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF93">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7174106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="206" mass="22996" checksum="35183DBFA8E90B12" modified="2022-05-25" version="1">MYSVNIFTDVQIRLMKDTLKHPKGFMLGAPEILQLNSNIMQTIRAKKVLDIGVFTGASALAAALALPPDHGGQVHGLDNNEEYTNMAKKYWSEAGVSDKIHLHIGDATDTLQKFIDEGQAGSYDFAFVDADKNDYNRYFEQCLVLVRSGGIISFDNTLWRGSVLDPQNQSDFTVAVREFNLKVKDDKRVNISFLKIGDGLTICFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TI57</accession>
    <name>A0A8J5TI57_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA repair protein complementing XP-C cells-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006708">
        <property type="protein sequence ID" value="KAG7174825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TI57"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="420" mass="47592" checksum="7CC149CA6562357D" modified="2022-05-25" version="1" fragment="single">ITTSEKIEENCSEESGEEDDKVEVKISWAAAEKCIETIIKFVEQNHSFSLQDVMHAHMVQNNLITKKLQSRKQGDFRKYLKKAVSSSAADAARVPSTSSAADDIEFEQIEQAKRAEEKRQKRIYDNWKKLIQGMLVKERVREMYGNVAPSDEEEDQKETETAKKTSEAKEKDTPRRKIKQEDIDAVRPPLITHQVRNLNIDLSSNVVEMAKKSRKRTMKTKNSIKRVVSKKGKTENTTGKDVKTEQVEEDNEESESDVEEKKAKIRAILQWGNKTVTANPDLSDDSDEERQSRPSSSHVGVPFSDPFYTVGEKQGQVKNKSGKGRKKSQAQEPSDCEEHVTSRSTSRSTTPEPDLGKAGCRRLSRRSAKQKIKTYKESDGENEGYISIDESDCEDKTYNPLKEKKAATHVLNLSEESNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIC5</accession>
    <name>A0A8J5TIC5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DM4/DM12 family-like protein 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIC5"/>
    <dbReference type="OrthoDB" id="6340174at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398">
        <property type="entry name" value="AGAP007094-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398:SF6">
        <property type="entry name" value="AGAP007094-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00718">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035212218" evidence="1">
        <location>
            <begin position="25"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="242" mass="27378" checksum="5E30C091872725DC" modified="2022-05-25" version="1">MMKVTSPSWRLMMVLLATFAAAAAESTASSVESLLGSALGSDTVRQGVSWSNSLEKEEMLRDTKNNRSTKGVGHQRVKRQLIDFADNAVMEFYFRLVVPYWTLPNVKTRGDYRLEVTYELPNQLLRRRKKRSLVNERSALYSLLGDFLSKAGLDGEECVLRAVCEVGEAPLEEYGILGEFINLIFAPGFQGDEFHRDHIQAEEYGRSYGNCWSAFPDCPMSLREMLHEFFLNNAEVPTENGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJ25</accession>
    <name>A0A8J5TJ25_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative minichromosome maintenance domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G009891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJ25"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058769">
        <property type="entry name" value="MCMDC2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26063">
        <property type="entry name" value="MCMDC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCMDC2 N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="199" mass="21700" checksum="651B0BFED5C215AA" modified="2022-05-25" version="1">MERTEHLQVAALRWLNHSGGLKRLRSALVARTALSPASKVLSTPVYINIAHLREIDEELANLVMSRPVVAQQMFHRVVHVASVAITLSLNIHSLNDNLEESGIAEDDHCAPGPLTHLPDPTDLTSLYLDEEDKSHKTSAPSHSFKRDAALNKVDLDLTLQSLASNLPLDSSVSGASTSVLTPAQVRLTTYLFLCLANNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TL59</accession>
    <name>A0A8J5TL59_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA-directed DNA polymerase from mobile element jockey-like 94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001007">
        <property type="protein sequence ID" value="KAG7177929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TL59"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="92" mass="10376" checksum="11036AFB2FD2D303" modified="2022-05-25" version="1">MPQETSEGKAKILSEVTNLNRKTVKILPLDPEEKTTRMVLLRYPLELPVEVIIKHPKVTKAERCVTSQDKAQTRQVLVDIKGTVPEEVDLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TL63</accession>
    <name>A0A8J5TL63_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor eIF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein translation factor SUI1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Eif1-L</name>
        <name evidence="8" type="ORF">Hamer_G015504</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TL63"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000010">
        <property type="entry name" value="Protein translation factor SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="7">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7176685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="110" mass="12305" checksum="891F0D3D75BD0319" modified="2022-05-25" version="1">MSIQNLNTFDPFADAARGTDEGVQDGLVHIRIQQRNGRKTLTTVQGLSSDYDLKKIVRACKKEFACNGTVVEHPEYGEVLQLQGDQRENICQFLTKVGLVKAEQIKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLI7</accession>
    <name>A0A8J5TLI7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TBC1 domain family member 20-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TBC1D20-L</name>
        <name evidence="6" type="ORF">Hamer_G022770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000655">
        <property type="protein sequence ID" value="KAG7178229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLI7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="107"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="320"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7178229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="407" mass="47408" checksum="F7490CE7952A2458" modified="2022-05-25" version="1">MEQETSNHLENSNVISEMLGDERTDKIDTKLGQVEATKKDVIEAEQFTEPEILNLAKTVKRRKKRPKPKNQVTMDRQKKMQQIQDVLSSTPLDLEALRELAIGDGGLVKDELRRKAWPRLMMIEHMEVTPKPALDVVKAHKDYQQVVLDVKRSLKRFPPGIDDDYRIILMDQLTGFHDVAITFLLVMGEDVGFEMVETLSITHLSEFMRPTMEKTTYYLTYLYPILHRANEKLYQFLIDSGVGTVFCLPWLITWFAHTLSDYRNVVRLYDFFLASPYLMPMYIAAAIVLLKKEDVPDSLPFEDILVAARKLYEEYPPDTLQEEVEEYLKKKAEEETLEKQRLIERRKKFDAKKLPYRKLMDAISHYVPFIPVQRQKLIKIVAFAATVFLARSLYNYCSTPAVEFVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLW1</accession>
    <name>A0A8J5TLW1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Insect cuticle protein domain-containing protein 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLW1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="184" mass="19969" checksum="EC7A114442477DF7" modified="2022-05-25" version="1">MAMPQVARDNTFTKILSFESFQDGNNFGHELAQEDGTTSGQKIGPDGLLYGFYSYIQQDGNRVKVLWRAGEGVGYEVLGVEGLNQEGLGNLRAHNQPSTAPRTVAPRPAPRSRAQSVPRVPPTPSHAPVHIPRTASTLPQGHFMPTPAPIYPQDPSHTPHRFDYPAVLNLERTGTGYVSSLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TPT2</accession>
    <name>A0A8J5TPT2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome transmission fidelity protein 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Chtf8-L</name>
        <name evidence="7" type="ORF">Hamer_G009137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TPT2"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7176342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="133" mass="15447" checksum="5D715129F428F265" modified="2022-05-25" version="1">MQIPIKITDKDGLEEWVMLELQGDLQSRTQSEMQNKFIGDLHFTKEGIPILIIGHHILYGKLQDLDKCYAVMRKTRVDNKKNMNVEVDGLENLPEDIPREKPCVEYTIRAIVKKKLLFKTRPKPIIASMQNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TV58</accession>
    <name>A0A8J5TV58_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G008356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TV58"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035167005" evidence="1">
        <location>
            <begin position="17"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="139" mass="15184" checksum="6644FC4742C8FE12" modified="2022-05-25" version="1">MNTFVLLLASIALVGAKGVGEFPNCWCGMFIEMDDEVHMVYHLESITVDSCDDVSICKTTCANEFNVFTSGGDLNHLLANGYSVGQEICLKMVEHHGIHNVYHAKVYGYANACNGPWAYDGVSSTNALCCHEGFYKACD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TVA8</accession>
    <name>A0A8J5TVA8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thyroid adenoma-associated protein-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Thada-L3</name>
        <name evidence="5" type="ORF">Hamer_G020909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001665">
        <property type="protein sequence ID" value="KAG7177843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73997at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF7">
        <property type="entry name" value="THYROID ADENOMA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="3">
        <location>
            <begin position="506"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="2">
        <location>
            <begin position="905"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="4">
        <location>
            <begin position="1181"/>
            <end position="1334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7177843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1861" mass="208686" checksum="888A1312CCD800A6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JE95</accession>
    <name>A0A8J5JE95_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Odd-skipped-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">odd-L2</name>
        <name evidence="13" type="ORF">Hamer_G021193</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043652">
        <property type="protein sequence ID" value="KAG7154863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JE95"/>
    <dbReference type="OrthoDB" id="5977959at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007366">
        <property type="term" value="P:periodic partitioning by pair rule gene"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000958">
        <property type="entry name" value="Odd skipped"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000254">
        <property type="entry name" value="Odd-skipped related transciption factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000311">
        <property type="entry name" value="protein odd-skipped-related 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF0">
        <property type="entry name" value="PROTEIN BOWEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0562">Pair-rule protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7154863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="260" mass="28682" checksum="07167A415CC6EFC3" modified="2022-05-25" version="1">MVASPPNVSGVGANFTPGALGSAFTPLSRVPPAFPLFLPSVSGGSVKQPMPPLGVDPRVMGMLHNYHSLGQLPWAALGAGDLALNRLLLTPGGRLSRPKKRYICKYCQREFTKSYNLLIHERTHTDERPFPCDICGKAFRRQDHLRDHKYIHSKEKPFKCEVCGKGFCQARTLAVHKAQHAHDSTPPTPILTPPSPRISPALPTCDSHDTDEVVDVLHCDDDDVVEDDVMQTVTEEDEELPVVVPPPKRLGFSIADIMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFT3</accession>
    <name>A0A8J5JFT3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038360">
        <property type="protein sequence ID" value="KAG7156855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFT3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="180" mass="20400" checksum="51870876419BDBFE" modified="2022-05-25" version="1" fragment="single">VEVGPPLPALSEGVIKDLSTDQSYAYRIAQAIRSGEVPQSLALLEIGPVSHSRWLTTALRFCRIWMLKNLRLIVEFIIGVYLPQWFSVKLNPMWVDGPNHLLFQLQLVRTQRKVVRDIVLPVARRSAWNARSEAVLQAMPCSQCTNLRTEAVEVILKIRGTLIDDDQLGDCSFHSRKVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFY1</accession>
    <name>A0A8J5JFY1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tigger transposable element-derived protein 7-like 60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIGD7-L60</name>
        <name evidence="5" type="ORF">Hamer_G005915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFY1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7157472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="286" mass="32610" checksum="80617ADDC1BE9598" modified="2022-05-25" version="1" fragment="single">LEDPGSSKEVQKRIKPAKFTDLDKAVYKWYKQEHASGINVHGMDIQNATARLAQHLKIQGFNASDGWVFTFRSRHCLVNRKVVVVEHIPIFPIKAAELAGFNLYKYQGECLVVLEDEGDMEVDMRGACTLENHKAHSICIAVFNWAEAWKSLSVTTLTNAWNKLLKDTEVEVDFPEFGTVDFVNLLHRSGETGVSEDNVAEWLEVDKAEQGFRHDTEKEIAASVSDKRQEQDDGDPSPRPNLFDLGFYLDKALRQLPDLKKCYTTIRNIRADVIKCQHTNFKQEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JG25</accession>
    <name>A0A8J5JG25_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glutamate receptor ionotropic, NMDA 2A-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Grin2a-L1</name>
        <name evidence="15" type="ORF">Hamer_G022937</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040247">
        <property type="protein sequence ID" value="KAG7156029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JG25"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="235"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7156029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="688" mass="77723" checksum="B2BD3E28261FB4E5" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JG81</accession>
    <name>A0A8J5JG81_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041065">
        <property type="protein sequence ID" value="KAG7155688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JG81"/>
    <dbReference type="OrthoDB" id="6355222at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035194865" evidence="1">
        <location>
            <begin position="17"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1263" mass="140384" checksum="D4160A4502B57BA7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGF8</accession>
    <name>A0A8J5JGF8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-directed RNA polymerase II subunit RPB1-like 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Polr2a-L22</name>
        <name evidence="2" type="ORF">Hamer_G025440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042962">
        <property type="protein sequence ID" value="KAG7155155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGF8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="741" mass="82051" checksum="BD48AA369408D8AA" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGM2</accession>
    <name>A0A8J5JGM2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">F-box only protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Fbxo11-L</name>
        <name evidence="17" type="ORF">Hamer_G020370</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the SCF(FBXO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with CIITA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036764">
        <property type="protein sequence ID" value="KAG7157827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGM2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22091">
        <property type="entry name" value="F-box_FBXO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19676">
        <property type="entry name" value="UBR-box_UBR6_FBXO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000003">
        <property type="entry name" value="F-box only protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000005">
        <property type="entry name" value="F-box only protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000006">
        <property type="entry name" value="F-box only protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000087">
        <property type="entry name" value="GG17321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047505">
        <property type="entry name" value="F-box_FBXO11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047504">
        <property type="entry name" value="FBXO11_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051550">
        <property type="entry name" value="SCF-Subunits/Alg-Epimerases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990">
        <property type="entry name" value="F-BOX ONLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990:SF20">
        <property type="entry name" value="F-BOX ONLY PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="F-box" evidence="15">
        <location>
            <begin position="185"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="UBR-type" evidence="16">
        <location>
            <begin position="861"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="13">
        <location>
            <begin position="861"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="60"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7157827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="956" mass="105324" checksum="1FCEDAF63AB1A8F1" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGS5</accession>
    <name>A0A8J5JGS5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrator complex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Ints12-L</name>
        <name evidence="11" type="ORF">Hamer_G022355</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041885">
        <property type="protein sequence ID" value="KAG7155365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGS5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160232">
        <property type="term" value="C:INTAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160240">
        <property type="term" value="P:RNA polymerase II transcription initiation surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15501">
        <property type="entry name" value="PHD_Int12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000101">
        <property type="entry name" value="Integrator complex subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039054">
        <property type="entry name" value="Int12_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051776">
        <property type="entry name" value="Integrator_subunit_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13415:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13415">
        <property type="entry name" value="NUCLEAR FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="139"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="204"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="256"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7155365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="324" mass="34866" checksum="954443D2AB135DDC" modified="2022-05-25" version="1">MNLLVCKSSTDMANLELDPLFRRGLRLLHSRSRDSLDQLKAIVDDAVRQRQGKTIPPMNKDPFSLRRESPIPRSKPGSPIPVSFSKREEIKKDMERKLSSHTPSPTPSVKSESSSRSRKSDESDSDTEMNDLAMEIMDEVNCTVCKSFEVSPRNRLVECQECHSLYHQECHKPPVTDQDVNDPRLVWYCAKCTKTLKKLTAMMSTSGGGSITGTRGVGGGGMPSVSGGGKSGGSHTRPTASPTKGPSLSRPSPFTNLSSASGRGLGSNNSGGNSNGTSKSSSSSSTSSSSGKSSAPSNSMISAERRMHLMKKKAAAKMAEKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JH44</accession>
    <name>A0A8J5JH44_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044763">
        <property type="protein sequence ID" value="KAG7154243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JH44"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="108" mass="12585" checksum="0B2ACAB4A58B0A96" modified="2022-05-25" version="1">MTATHRYTPSWICLTATHQHKRGSVMTATHRYTLLDLQAATHHTPWICRDRHSPYTPSWICDCHSLLHPAGSVMTATHRYTPSWICHDCHHHYTPSWICHDCHHSLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JH74</accession>
    <name>A0A8J5JH74_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U-scoloptoxin(01)-Cw1a-like 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G005967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JH74"/>
    <dbReference type="OrthoDB" id="6407151at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035203436" evidence="1">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="48"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="160" mass="17982" checksum="C11E6AAD874CF513" modified="2022-05-25" version="1">MFAKNIIFAVCVVGTCLALPRTRRDSSPEEYELPGNATAILVNPLQTGFTCGQRIYGYYADVDNGCQVFHVCHPFVDVDLLIKMRMFSFICGQGLVFDQEKLVCDFPENSVPCEAAAQFYDINNYFGRVDLNFREGETPLAPTSTDFQVQTFSELSQSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ32</accession>
    <name>A0A8J5JJ32_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DDB1- and CUL4-associated factor 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">WD repeat-containing protein 68</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">WD repeat-containing protein An11 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Dcaf7-L</name>
        <name evidence="15" type="ORF">Hamer_G020619</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat DCAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033198">
        <property type="protein sequence ID" value="KAG7159392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJ32"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000049">
        <property type="entry name" value="DDB1-and CUL4-associated factor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="265"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7159392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="346" mass="38983" checksum="2810B8F418B2EEC8" modified="2022-05-25" version="1">MSVHPPPKRKEIYKYSAPWTLYSMNWSVRPDKRFRLAVGSFVEEYNNKVQIVQLDEDTSEFVVRSTFDHPYPTTKIMWIPDSKGIYPDLLATSGDYLRVWQQGADGDTRMACLLNNNKNSDFCAPLTSFDWNEVEPNLIGTSSIDTTCTIWGLETGQMLGRVNVVSGHVKTQLIAHDKEVFDIAFSRAGGGRDMFASVGADGSVRMFDLRHLEHSTIIYEDPAHTPLLRLAWNKQDPNYLSTVAMDACEVIILDVRVPCTPVARLNNHRACVNGIAWAPHSSVHICTAGDDHQALIWDVQQMPRAIEDPILAYTAAEGEINQIQWGATQPDWIAICYNKCLEILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJD7</accession>
    <name>A0A8J5JJD7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G004223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJD7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="207" mass="23478" checksum="4CBC48A7FB5BD287" modified="2022-05-25" version="1">MIIPDGVLVLWDQKYAVNAADLATETADVPLHSMNFTTTLPITTHHNTKPSPQQYPITITQLHHITTHHHTALHHTFTTTLPHHHNTTPSSQHTFTTTVPHYHNTPSPQHYPITTAHLHHNTTPSPQHTLTTTLHHTFTITPPITTPQHHNTTHHHTTTLHLHHNTTHNHTTTLHHTFTTTLPITTPQHYTFTTTLNQYHPITTPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKT8</accession>
    <name>A0A8J5JKT8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamate receptor ionotropic, delta-1-like 37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Grid1-L37</name>
        <name evidence="11" type="ORF">Hamer_G031238</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031612">
        <property type="protein sequence ID" value="KAG7160232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKT8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF38">
        <property type="entry name" value="IONOTROPIC RECEPTOR 100A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="116"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7160232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="412" mass="47117" checksum="E9C1DC141C1882EC" modified="2022-05-25" version="1" fragment="single">MDFERRTEEPGGIINPKDSIDTRLIYAFASALNFTFEIREEPERTWGLEINGSFTGMIGQLQREETDFCTIAGPSPERLKVVEYLRGYPSDLMTVTSLKPSLLPQHLSLIRPFEGELWLALMVSVVAWGGVMWILQRTWRWFAGGRRVDFSTTLLYGWGALLEQPPPVLSVSNSGRLLVGWWLVFCLVITTGFRSSLVAHMTVQGKTLPIETFEDMVKQDNWKWCTEPWLLKGMLFDYFSKHTDPVVQKLYKHMEMLVADEALERVLEGGFTLVDFENYVNIIVASRYTDARGYNPFYVSKKGVSVMAAFGWGMRRGAPFYPRFKQLKSRLEDTGIISYWIEDVIARRVRENRAAAAMDDDNKVPLGLHHMQGAFYLLFLGYVVALLILFGETISHNSDPRISTTFLTTNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKW7</accession>
    <name>A0A8J5JKW7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Best2-L6</name>
        <name evidence="8" type="ORF">Hamer_G012726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKW7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF65">
        <property type="entry name" value="BESTROPHIN 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="287"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7160182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="615" mass="69263" checksum="C065D7EF6E95186F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JL19</accession>
    <name>A0A8J5JL19_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043233">
        <property type="protein sequence ID" value="KAG7155094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JL19"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="104" mass="11676" checksum="3A3FD4E71752D7A6" modified="2022-05-25" version="1">MHFLSPLISFTSLRLLPSFTFYIIFLHFILLVGVASCLPGLRRRRDSSPDFFELLSNASLILGSITSGFGCSDLPYGYYADEANNCAIFHVCLPYIDFGQIITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLL4</accession>
    <name>A0A8J5JLL4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Filamin-C-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Flnc-L0</name>
        <name evidence="3" type="ORF">Hamer_G008884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLL4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="187" mass="20514" checksum="0EB19A7C792D58C1" modified="2022-05-25" version="1">MCVRTTIPIGEKEEYLVKWVGDKVPSRRVSVLGRDLADGVTLCGLLEALVPGTCPRHDLLPPDQPEANLRIASRLANDFLGVTQDISGGGSGVLYYFLRRVRYAALKRKVLGGPPVTPEAVAQTLGSHQVRQEAPSLSTVLAQKMGIDCWRRRRQPRGSRRTSMSDILHSSQTTITTTNPLQVGAHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNP3</accession>
    <name>A0A8J5JNP3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036543">
        <property type="protein sequence ID" value="KAG7157873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNP3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="251" mass="28792" checksum="A4B006C6D7F0E760" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLATLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JP67</accession>
    <name>A0A8J5JP67_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Tc5 transposase DNA-binding domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G014055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JP67"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7161416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="317" mass="35409" checksum="8196371775CF74D5" modified="2022-05-25" version="1" fragment="single">MSEIRHQARVYYAAVAQKKHINSPPPFNASVGWLAAFKKRNEVKFAHYHGESALAGVTGSLVEVQQIDAELSDSDQALPANQEEEETCEFGKKYNIKNAVDRIVEAWRKINVATVLHAWKPLFANSEITTLMDTVEAKRSDPALGFSDVQVEDLQEIVGQHQQQPTNEDMLEDEEQEEQLPSQEDDVKPGEPTTRQLTELLTNIAHVCEQLEEYDTRPHPWNLMCSALEKVVEEYKALYVSRAQPVNALANITLGDDDGTTDDDIEVLGDLLVEELPQDFEGFDTEVRGGSREEAVTSPPCLRTHQPVPSSISLISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JP68</accession>
    <name>A0A8J5JP68_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FucTC-L5</name>
        <name evidence="15" type="ORF">Hamer_G008803</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JP68"/>
    <dbReference type="OrthoDB" id="6355192at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="225"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="398"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7158173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="617" mass="71232" checksum="987278A91F5456B8" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQF2</accession>
    <name>A0A8J5JQF2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome-binding protein 1-like 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Rrbp1-L22</name>
        <name evidence="2" type="ORF">Hamer_G031263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032426">
        <property type="protein sequence ID" value="KAG7159745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQF2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="326" mass="38192" checksum="0E03FC6EFF65D39D" modified="2022-05-25" version="1" fragment="single">DPENMWAYEVDARSTGDKKSAREERRGDVVVGQYSAMDPDEPKPIAPAKAQPVPESTDPPRPVPEPTEPPQPVAEPTEPPRPVPETTEPPRPVPEPTEPPGQFQNQLSTRDPFQNQLSTRDQFQNQQSRPDQFQSQQSRPDQFQNQLSTSDQFQNQQSRRDQFQNQQSRPDQFQSQQNRPDQFQNQLSTRDQFQNQQSRGDQFQNQQNLPHQFQNQLSTRNQFQNQENRNQYQSNYRTSTNQYNHNNQSNNLHNNRYISQSYGSTNNNHNYNQNSHLNSNLFNLEYNQQPSRLSTNNHNQYGRSQVSVVPAGNHKYRLQQMNHWQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQN6</accession>
    <name>A0A8J5JQN6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nose resistant to fluoxetine protein 6-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nrf-6-L3</name>
        <name evidence="4" type="ORF">Hamer_G017327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7159895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQN6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035190292" evidence="3">
        <location>
            <begin position="26"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="606"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7159895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="658" mass="74192" checksum="FF9A450ECD2DA7B9" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRG8</accession>
    <name>A0A8J5JRG8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G018326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027102">
        <property type="protein sequence ID" value="KAG7162796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRG8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035326487" evidence="2">
        <location>
            <begin position="37"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7162796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="328" mass="36278" checksum="6796C72802591F66" modified="2022-05-25" version="1" fragment="single">MDTLDCHPQKMVLMLRTLSLLLLLLVAAVLSSTVQTDTVTLITASPPPTLTGRRINYSRVRVTVSGKDGIVCPLTSVTSHLLNMSAKRKIKSAAPTMLATVRSVHPQNTVIPRVLQVLPAQMVLLVQMVLLVQMVQLVQMVLLVQMVLLVQMVLLVQMVLLVQMVLLVQMVLLVQMVLLVQMVLLVQMVFQAQMVFQAQMVLQAQMVLLVQMVLLVQMVLLVLKVLLALKVPLALKVLLALKVLLALKVLLVLRALQVILALMDPQDLKDLQVLKDLQVPKDPLVPKDPMAPKDLRAIKVIKDLPATNILKALMIIQKIKPTVNQGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRT9</accession>
    <name>A0A8J5JRT9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Coq9-L</name>
        <name evidence="14" type="ORF">Hamer_G002218</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the COQ9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRT9"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.10:FF:000004">
        <property type="entry name" value="Ubiquinone biosynthesis protein COQ9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048674">
        <property type="entry name" value="COQ9_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02396">
        <property type="entry name" value="diverge_rpsU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21392">
        <property type="entry name" value="COQ9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="14" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="5 9" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="11">
        <location>
            <begin position="74"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquinone biosynthesis protein COQ9 HTH" evidence="13">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="COQ9 C-terminal" evidence="12">
        <location>
            <begin position="314"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7163142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="380" mass="43089" checksum="BE7F28320181C8FF" modified="2022-05-25" version="1">MSRRVTARDDIAAVIALYKANHVLREISAQTGVALRVVQNLVKRFCDLGEDELPAPLPKSGRPKLLSPRTLKVISRQVRSNPSLTAHEVKERNPRLLSHVSLRCVQQALHDDLGFKSFRARRKPLLTKRQKENRVKFCKKYEVWDLETWRRHVNGVRTSCASWSHEQTTQSKEQNFAESSTPHDEESFDHGTEDGEAQLRSHILNAALPFVHSYGWSPDAIAQGAETLGYSSMVHGMFPGGGVELVNHFYSTCNTILEESLKAKVKKVEEKPELKTGTTAFIANAVEERLRMNIEYIDSWHKALALHASPRNTTTALHNLGTLVDHIWYHAGDRSTDFNWYTKRGILAAVYKSSELCMLQDKSEDFQVLNIVGMNSKSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSL5</accession>
    <name>A0A8J5JSL5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G028622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029569">
        <property type="protein sequence ID" value="KAG7161298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSL5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="448" mass="51218" checksum="8EDE09CB5649916A" modified="2022-05-25" version="1" fragment="single">MRIQTNLDSLPDLPTQSPSATHNLNATATHNLDASATHDLNATATHNLDASATHDLNATATHNLDASATHNFDFSATHNLDASATHDSKRQSSEPVYIKRRKPRLVELRHQRLFTKNVVARRDQYLRLVTAARRDQYLRLVTAARRDQYLRLVTAARRDQYLRLVTAARRDFLKSVTRSRSRPLCNKRLGNKELINDMIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTI0</accession>
    <name>A0A8J5JTI0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029194">
        <property type="protein sequence ID" value="KAG7161500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTI0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="183" mass="19958" checksum="59CB13A85FAE74F5" modified="2022-05-25" version="1" fragment="single">MESTRSKTEVWLIGQHITEITGAQLPSRGDVLRLFFHGHNEHKKTVNDSASEVAASRNEKKERRGVMAGVDKKIACSIKRREESKSKQSLQQNQASSALEYDELGSSSETESQSSSSSSTSSLAISPVVSSSNRKRATLKVITPELSSTLDRTGISHRSTLRIVSATAASLGHDPMELVLNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV21</accession>
    <name>A0A8J5JV21_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JV21"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="189" mass="20934" checksum="FBBF8020A1DB1502" modified="2022-05-25" version="1">MAALALSGCDIIAHLHGIDKVTAIQTLKSGHRFDKFGKIVAEITEVVSQATRFVAACYDSKVIHDMSTVRFNVWTSKMSNKRLTSAPELRCFPPTTAAFELHVLRVHYQTMIWRTALEVGPPNHDPRQYRWSSDQASNLLLPVTLPLDVSPVPDSVQKLIKCSCSTNLPCSTDRHSCVAAMLSCSIFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JX17</accession>
    <name>A0A8J5JX17_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JX17"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="179" mass="20510" checksum="9447A872DFB27E28" modified="2022-05-25" version="1">MVRIKEMKSQTEIHEPEQVRNIDKSSSSDSDSASSNKEIDFDSYLDTIEQAKVKRHRSENAAAVDIKNTRFQQDFFGALMEVEKFDRSSKVTVEEAIPAYPEIVKDVARAVTAMPPTQASLFKDTLNPRTRRAGPEEDWYHFFYPFELGSGGFFLETTDEKNNLTDLHQYDGILIIINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXA3</accession>
    <name>A0A8J5JXA3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">inx2-L8</name>
        <name evidence="12" type="synonym">inx</name>
        <name evidence="14" type="ORF">Hamer_G019877</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022770">
        <property type="protein sequence ID" value="KAG7166095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXA3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="313"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7166095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="388" mass="45249" checksum="2311537CE5126731" modified="2022-05-25" version="1">MCGYLRRPRAQDALSVDLLSPAGYLPHGVVLVVRLDYINICLSYPFVEEDGSRRYLLFYRWISWSFAFLAAVYYIPRKVSKSFDNARCKKLLEDLAANAHRYDQAERELVERAARYIIFNIKTHNGLYWKFLTVNIIALLVDLFAMQFLDFLLQGRFIQYGIKSYPFSRDPHTFTDYISKTFPPFASCEIAKQNQLVNKRTEMFGCHLTIMELYEKLFLGLWVWLIMLTFVTCCYIIFLFLMWLPCVRVYLLRVAKPVHASDKVRGVVHAVTQNCKIGDIYLLYRLKGHLSHARFYELMVRLSDPNLCNKQIQQSGPGVMPESKDKVPPNKQADTLRQRRPNMPQDPPVNPEYLHQLLAGNPEMMGRHPQHPDQRTPLLKTNTSILIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXC1</accession>
    <name>A0A8J5JXC1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024171">
        <property type="protein sequence ID" value="KAG7165537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXC1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="203" mass="23613" checksum="05EC12724F166780" modified="2022-05-25" version="1">MYVRFWHEAPMAVRAPFNDLQLIKVLKEYPHEKVAHAAQAAISRHLWYLSEHLIGLSLFDDRIDTETKKNMVQNFQCPKKQDFSRRIVLSDETPISNVASFVTERTLDIFDVLTLDGKERAQLFLSKNPKTWKDDEVFITMRDRAINMKVVNDSAERAIALIERYNESITQNEDQKQYLLQVVAAHRKKLPTASKAAMMKGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K048</accession>
    <name>A0A8J5K048_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Intraflagellar transport protein 140-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">IFT140-L</name>
        <name evidence="9" type="ORF">Hamer_G004806</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K048"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056156">
        <property type="entry name" value="TPR_IF140_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 140 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24760">
        <property type="entry name" value="TPR_IF140_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="8">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="IF140 C-terminal TPR" evidence="7">
        <location>
            <begin position="307"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7165048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="501" mass="56281" checksum="0AC3F57F9C81F17E" modified="2022-05-25" version="1">METALQFYEAAHDHLSLVRVYCYCNNLQKAADIANETGDRAACYHLARQYENVAQVKEAIHFFTRAQAFGNAIRICKENGHEDQLMNLALVAGPQEQIDAARYFSSNERRQLPKAVMLYHKAGLLSKAVDLAFKSGQISAVGQIAGELDESADPALIQRCAQYFISNGQYDRAVSLLITGKQYSDALDLCVEHNVWVTEELAERFTLPKDESARNQILEKVAECAYAQDNYKLATKKFTQAGNKVKAMKCLLKSGDTERIVYFANVCRQREIYIMAANYLQSLDWRKEPDIMRNIIQFYSRAKATALLAGFYDSCAQVEIDEFQNYEKAAGALNEGYKALMTSSDPQAQERVPAFQYKLEKVKQFLGIKRMFATDGDSAIQELQELLADPNIEVAVRQGDIYAVIVEYYASNNNFKSALGALQEMKSKLPKANPNYYVEAQTLQAISRTTGVNFGRTENGGLDEGGSEEEGNASEEEVVEEEEEDERPQQHFAHNGSAKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K066</accession>
    <name>A0A8J5K066_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease</fullName>
            <ecNumber evidence="10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Rnaseh2a-L</name>
        <name evidence="13" type="ORF">Hamer_G004662</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="10"/>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7164939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K066"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="12">
        <location>
            <begin position="28"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7164939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="279" mass="30868" checksum="D340DCF34EAA16F2" modified="2022-05-25" version="1">MDLATYSDKNWVNTFVDSTIPDICKEEPCVLGVDEAGRGPVLGPMVYGICFCPVSKHEDLKAAGVADSKTLSEEQREKIFSIMHENSDYIGWSLEVISPLNISNSMYKRPKVSLNEVSHNAAIGLIKRAIAAGVKVSEVYVDTVGPPEKYQAKLQDVFPTIKVIVEKKADALFPCVSGASICAKVARDRALKKWEFPEGTEVDNWGSGYPGAEKIIDEKCVPVTWNDEDEEDEKDKTPSVLQFFARKHKSSDGGSAAPPPPKKRHHFFTERCLKSVESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0R5</accession>
    <name>A0A8J5K0R5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SAGA-associated factor 29-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Sgf29-L</name>
        <name evidence="6" type="ORF">Hamer_G026094</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020966">
        <property type="protein sequence ID" value="KAG7168060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0R5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000026">
        <property type="entry name" value="SAGA-associated factor 29 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047287">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="5">
        <location>
            <begin position="48"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7168060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="163" mass="18338" checksum="A89609EF3A3AFFB5" modified="2022-05-25" version="1" fragment="single">AKNSGNKETIRRGALMKMLLNCAQTLPLWIGNSGEKPPALCGAVPPEQNYVAKVNDMVACLVRGSEGEDNWILAEVVSYNTTTNKYEVDDIDEEQKERHTLSLMALYPQTTCFYKAVINRLPTLATEEYEVLFEDPTYADGYSPPLMVAQRYVIQIKEVSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3T9</accession>
    <name>A0A8J5K3T9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peroxidasin-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Pxdn-L1</name>
        <name evidence="7" type="ORF">Hamer_G011522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3T9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF4">
        <property type="entry name" value="CHORION PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7168856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="494" mass="54967" checksum="F69F4BC831BCE6B8" modified="2022-05-25" version="1" fragment="single">IGQFIDHDLALISIITGTCRQESQGGRRVREAGESGRQSVDSVGADSTPKKCEACSMWRDDPACAPIPIPQDDSHLQPQDLYSGQRRCLSFVRSGAVGGRDMQGLPTLDQTSVCTAFLDLSTVYGSDECRERDLRLYFGGMMVEVKPGNSRRGFPPTTDAHHFEDCRSDKNKCFLAGDDRNNEHLALMVIHTLFFREHNRLATHLSALNPHWGDETIFQEARRINIAQYQHIVYSEFLPVLLGQQKMADYRLTPEKSGYYQGYDARVNPGVLNEFATSAFRVGHTMVPNRLFLLDHNYFPLASVPLVHTFHNSSLALKGAILNQLFQGLHTAPQDLFARNIARGRDHGIGPYIKYRAACGGEAATSFDDLLRVMSQSAVAALRQAYAHVEDVDLFPGGLAENHVPGGLVGPTFACIIAYQFLNSRRGDRFWYENADAGLTPPQLHDVRTSSSLARLVCDNLDEDDARIPANMRCKPQLSGCQQPNQDEHCQLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K432</accession>
    <name>A0A8J5K432_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RTN3-L</name>
        <name evidence="9" type="ORF">Hamer_G005471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K432"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046964">
        <property type="entry name" value="RTN1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799:SF2">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="47"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7167129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="235" mass="26577" checksum="7DB2AA1F6381064E" modified="2022-05-25" version="1">MGRRNSKEKNGRDSPDDIEEPPVTRGPGNNPACIMIIIVLKWLCFAVVDLIYWKDVKKTGVVFGGFLALFISLAYVSFISVLSYTSLTVLSVTIIYRVYKNIMQAIQKSQDGHPFKNLLELDTDLPLEKVHDASDAFVNWWNPKFTEVKRLFLVEDLVDSVKFGCLLWCLTYVGSWFNGLTLVTLATVALFTLPKVYEQNKTQVDQYMGLVKNQVNDVMSKVKAALPIGNKEKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K443</accession>
    <name>A0A8J5K443_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease P/MRP protein subunit POP5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">POP5-L</name>
        <name evidence="4" type="ORF">Hamer_G010442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K443"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48414">
        <property type="entry name" value="POP5 HOMOLOG, RIBONUCLEASE P_MRP SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48414:SF1">
        <property type="entry name" value="POP5 HOMOLOG, RIBONUCLEASE P_MRP SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7166780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="194" mass="21858" checksum="9FD9ED86B6ED69AC" modified="2022-05-25" version="1">MMVYNHLQYCTYSLIINNCSRYCVVELVAENCVYFGRDGLQKAVVEAVKRLHGDFGVSATTPGFHVKYFNIKTRIAFVSVGRGPHQLVASALPLITQIGGQPASVRIIHLAASMRHGFLFVKRNVLGYYLWSWSITEECCDNTTAAIPSISKSTLGIMIMWLITFLYIHSCFHLQGYHEKKLKASQVSCKKEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5R5</accession>
    <name>A0A8J5K5R5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Paraplegin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SPG7-L</name>
        <name evidence="20" type="ORF">Hamer_G013353</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015640">
        <property type="protein sequence ID" value="KAG7169722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5R5"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000277">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000033">
        <property type="entry name" value="paraplegin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF8">
        <property type="entry name" value="PARAPLEGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="347"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG7169722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="783" mass="86760" checksum="AF45AC2633989608" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K695</accession>
    <name>A0A8J5K695_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome-binding protein 1-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Rrbp1-L3</name>
        <name evidence="3" type="ORF">Hamer_G010233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K695"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="37"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7167830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="785" mass="88944" checksum="63D40D5E22193BC0" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6M2</accession>
    <name>A0A8J5K6M2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Alcohol dehydrogenase transcription factor Myb/SANT-like-containing protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014926">
        <property type="protein sequence ID" value="KAG7169932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6M2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="84" mass="9808" checksum="3B45816EBBB06D48" modified="2022-05-25" version="1">MGKPFPPDESSQVTSHRVTSNHRWGWAHFLHQSRRVRSGVYIMQVDVLINLFRERPAIYDPTDRSHRDRDVIAALWKEVAAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7X7</accession>
    <name>A0A8J5K7X7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Prp38-L</name>
        <name evidence="9" type="ORF">Hamer_G005590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022531">
        <property type="protein sequence ID" value="KAG7166479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7X7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="263"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="397"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7166479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="476" mass="57302" checksum="C41BBBE79DFFA374" modified="2022-05-25" version="1" fragment="single">ASVSVVLVNMANRTVKDAQSIHGTNPQYLVEKIIRTRIYDSRYWKEECFALSAELLVDKAMALRCIGGVYGGNIKPTPFLCLVLKMLQIQPEKDIIIEFIKQDEFKYVRGLGAFYLRLVYGSLDCYKYLEPLLNDYRKLRLMDRSGQYQLAHMDEFIDSLLRDERSCDIILPRVQKRWVHEANNELEGRVSLLDDDLDDLESESDEEELLPPPRPRNDPVEPMRTAPSRDDRHGRGHSPSRRSPQRDMRNDREREKRHRSRSRSRERDRGMERDRGMDRIERDRGMERDRGIERERGMDRDRMDRERGMERMERDRGMERMDRDRGMERMERDRGMERMERDRGMERERAMERDRGMERERGMERERKRHRSRSREKRHRSRSRSPGHHLHHHRDRGRGGEKERDHRHGERAERDHGKERNRDHRERDRDRGDRKEKHHRSGRSKRDNMMGMSREDLEIAEANALRARLGMPPLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8P1</accession>
    <name>A0A8J5K8P1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7027 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G002639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8P1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054291">
        <property type="entry name" value="DUF7027"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053077">
        <property type="entry name" value="MARVEL_domain_protein_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34609">
        <property type="entry name" value="GEO08273P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34609:SF17">
        <property type="entry name" value="GEO08273P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22954">
        <property type="entry name" value="DUF7027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7027" evidence="2">
        <location>
            <begin position="43"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7168553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="134" mass="15279" checksum="84C6FEF1F08A1F27" modified="2022-05-25" version="1" fragment="single">MRDQWALTKCCCCFDLSTGALFIGLLWMITRCLEISIRFTLLKFDKVNDWQLALCIPMFISVVSCISLVVGVIKERPAWMTPWLVIECFTLLLKIYSMVMAFVDADTLFGLACVADMILCSYFIFAVLSYSIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8S1</accession>
    <name>A0A8J5K8S1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mediator of RNA polymerase II transcription subunit 27-like 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 27-like 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Mediator of RNA polymerase II transcription subunit 27-like 5</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 27-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MED27-L5</name>
        <name evidence="1" type="synonym">MED27-L2</name>
        <name evidence="4" type="synonym">MED27-L3</name>
        <name evidence="3" type="synonym">MED27-L6</name>
        <name evidence="1" type="ORF">Hamer_G028711</name>
        <name evidence="4" type="ORF">Hamer_G028844</name>
        <name evidence="2" type="ORF">Hamer_G030263</name>
        <name evidence="3" type="ORF">Hamer_G030303</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031461">
        <property type="protein sequence ID" value="KAG7160261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010016476">
        <property type="protein sequence ID" value="KAG7169466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010014604">
        <property type="protein sequence ID" value="KAG7170247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010006541">
        <property type="protein sequence ID" value="KAG7174864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8S1"/>
    <dbReference type="OrthoDB" id="1868004at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7174864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="169" mass="18884" checksum="F9AC4C2B0C8D0412" modified="2022-05-25" version="1" fragment="single">LVLPIQKDLAVRWREVGREGRTSGTLLSDCLAVRWREVGREARTSGSVNMAAPEGTSVETLTVTLNTLRTLRSSVTLFFKFISEGNRDENSNEGDSSVHEEAMKVMADVKCHLRELETQVAGLNPPSNPVNLGNTGLLSLDPSPDKLPLYYQLLDCYTWMEKVRNKYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KQ71</accession>
    <name>A0A8J5KQ71_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acid phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ACPP-L</name>
        <name evidence="8" type="ORF">Hamer_G026050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010012597">
        <property type="protein sequence ID" value="KAG7171234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KQ71"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7171234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="146" mass="16293" checksum="50999B250AA8A28B" modified="2022-05-25" version="1">MYMYSAHDTTLSILLLGLGVFNNLAPPYATTVLVELHKMDEQYYVKMFLRNDTNMIEPPHELILPGCSTVCPLDRWNTLVNAIIPHDWKRECGVSEPFKLSTGALAGLTAGILLAVILLVALIKNVLGCKRGSHQFEYQTVPNNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJ45</accession>
    <name>A0A8J5MJ45_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G019510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046868">
        <property type="protein sequence ID" value="KAG7153454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJ45"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="148" mass="16721" checksum="C698391A8FDEDE06" modified="2022-05-25" version="1" fragment="single">DYPRLITRHRLPQADITCQRLPQADITCQRLPQADITCQRLPLADITCQRLPQADITCQRLPQAVITCQRLPQADITCQRLPQATTQAYIACHRLPQADITCHRLPQADITCHRLPQADITCHRLPQADITCHRLPQADIILPQTTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPK8</accession>
    <name>A0A8J5MPK8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Muscarinic acetylcholine receptor gar-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">gar-2-L</name>
        <name evidence="14" type="ORF">Hamer_G011474</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPK8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15302">
        <property type="entry name" value="7tmA_mAChR_GAR-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000221">
        <property type="entry name" value="Muscarinic acetylcholine receptor gar-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF191">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR, B-TYPE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="913"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="951"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="122"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="333"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="528"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="692"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="753"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="802"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="888"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="699"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="753"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="765"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="896"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7158797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="989" mass="106645" checksum="26BCCDA477CA34E7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPY6</accession>
    <name>A0A8J5MPY6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">1-acylglycerol-3-phosphate O-acyltransferase ABHD5</fullName>
            <ecNumber evidence="5">2.3.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Abhydrolase domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">Abhd4-L</name>
        <name evidence="27" type="ORF">Hamer_G016610</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors. Functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37455"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74938"/>
            <dbReference type="ChEBI" id="CHEBI:74941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:37456"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37443"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74928"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:37444"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37131"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:37132"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37143"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74551"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:37144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37147"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74552"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:37148"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:33187"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57518"/>
            <dbReference type="ChEBI" id="CHEBI:64839"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:33188"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-octadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37163"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74560"/>
            <dbReference type="ChEBI" id="CHEBI:74565"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:37164"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:19710"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>eicosanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37451"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74937"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:37452"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPY6"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000019">
        <property type="entry name" value="1-acylglycerol-3-phosphate O-acyltransferase ABHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="25" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035278843" description="1-acylglycerol-3-phosphate O-acyltransferase ABHD5" evidence="25">
        <location>
            <begin position="28"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="26">
        <location>
            <begin position="152"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAG7159217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="482" mass="54458" checksum="86FF1967F0C211DE" modified="2022-05-25" version="1">MSYGLQVLWKVLLVVLQILLLLHFSQGQENVSGPRKRVSKWKGVMLALTHVGEYNETLWPVIYETRDEEDVECTSSLDPEAVDKCSSDDSWFGSWLRWCPTSLSLLREAEKAVLSNLKGSYRGHYVNVGCAIDKTESHIWTVSFNEESDNVPLVLLHGFGSGVGLWCLNFDSLSASRPVYAIDIIGFGRSSRPTFTKDPLEAEREFITSIELWRQKLALEQFILVGHSFGGFLAASYAIKHPERIRHLILADPWGFPERPLDVAERYKFPFWVKAVGAILQPFNPLFVVRTAGPWGPKLLQKARPDLIRKFSGMVKDAEEVIPSYLYHCNAQNPSGESAFHTLMAGFGWAKYPMIQRMDSLRKGMPMTLIYGSRSWVDRDPGFQIKYMRNDSYVNVQVIPGAGHHVYADKAEIFNNLINNIGKHVDDGTLPALAPDLPTENTEENQDDVGMSFSKIINVRNDNLRDETTVQVDMNVSAEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPY7</accession>
    <name>A0A8J5MPY7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein axonemal assembly factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Dnaaf1-L</name>
        <name evidence="9" type="ORF">Hamer_G004084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cilium-specific protein required for cilia structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNAAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPY7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF9">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7159456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="95" mass="10540" checksum="B264EB90D57D3C72" modified="2022-05-25" version="1">MTGIMSAREKLTVGPSADTKTQTKTCYTEIENLEEYTGLRCLWLENNGLRSINGLQHLQHLRSLHLHHNLLTCLNGGITTAAGSVSRPLLFRPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRA6</accession>
    <name>A0A8J5MRA6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030986">
        <property type="protein sequence ID" value="KAG7160701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRA6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="70" mass="7491" checksum="6E5B0C6EDD32027E" modified="2022-05-25" version="1">MTVVIGSCFSSRLGYLPPPPNGNGNGGYTNGNGVNGNVNGVKSMAAQWQQHSGYTNSSRSIAGKWQRWIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRM7</accession>
    <name>A0A8J5MRM7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette sub-family A member 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Abca5-L</name>
        <name evidence="7" type="ORF">Hamer_G024887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029326">
        <property type="protein sequence ID" value="KAG7161468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRM7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF209">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="6">
        <location>
            <begin position="231"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7161468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="584" mass="64604" checksum="4BEE7FCAE37E0A45" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRX2</accession>
    <name>A0A8J5MRX2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRX2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="97" mass="11716" checksum="E96D3C01D3457178" modified="2022-05-25" version="1" fragment="single">TLFKKAVLQIKNEERSEQRGASVSVHHYDKHCDTKYKHGRNKCLTWLSDVQRKYRPCWGFMRNPYFALTQCRIYGDNRKHSLQYYTLECRPIRFVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSG2</accession>
    <name>A0A8J5MSG2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G008019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSG2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035156840" evidence="2">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7162470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="87" mass="9550" checksum="9699E971F5232658" modified="2022-05-25" version="1">MGGEGQSACHNSIAPRPKLVPTSGETAMNLVSMLVLVMAALLAPVSSLPEPDVLLDRATDLQDQGWVQPPRFHYRGFQRPNPRTNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSH8</accession>
    <name>A0A8J5MSH8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">B3galt1-L5</name>
        <name evidence="11" type="ORF">Hamer_G019931</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAHLQT010028706">
        <property type="protein sequence ID" value="KAG7161917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSH8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF364">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7161917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="311" mass="36069" checksum="BC0BD74BB36C5827" modified="2022-05-25" version="1">MIVLVALCRREYAVRPPIPDNPRDSPVCRPANIPNKFLIEEEDFCQRGQPLQVVSFVHSSISRVKKRMETRKTWANASAYGLGTHNGVVFMVGRAKNPHEEMIVQNESLLYHDIVQGDYGDHYQLLSYKALAAMNWITRHCSHVPWTLHADDDLIIDSFLLQEFIQTLNSESKKQIICRRMVGRVLRKGKWKVTREEYSAKMYPKYCQGTMWLLATEQLPKLLEASKEVSYLWVDDAFITGLLVQKAHIGLKDIGSKFTRIFKRSDIGKKIAWWHLPNVNSTAIWRQIVHYHKQRYKPNPSQPNSIQPNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MT92</accession>
    <name>A0A8J5MT92_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcriptional repressor CTCF-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Ctcf-L1</name>
        <name evidence="12" type="ORF">Hamer_G008125</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MT92"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001249">
        <property type="entry name" value="CTCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000395">
        <property type="entry name" value="zinc finger protein 513"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF43">
        <property type="entry name" value="ZINC FINGER PROTEIN 513"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7162561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="178" mass="20492" checksum="848714BA81148685" modified="2022-05-25" version="1">MLQLLEAVDSHTYQDKAIGIKIVDAGKMYIGVDILLTFTYMERQAQTDGRRTTGEWQGLNTSGMMHECPHCAYSTVYLNQLWKHISSMHTGAKPYICPYCPYRTTRNTLLKEHINTHTGERPFSCSYCPYSSSHRNILKRHIRTHTGEKPYTCTMCSYRAASKTNLNSHLLTHKKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTD0</accession>
    <name>A0A8J5MTD0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pro-resilin-like 169</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G027599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027611">
        <property type="protein sequence ID" value="KAG7162604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTD0"/>
    <dbReference type="OrthoDB" id="6884310at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035241050" evidence="4">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7162604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="132" mass="14451" checksum="76F0CA32181D9229" modified="2022-05-25" version="1">MVLKVFVIAVLVAVTIADTIPYTPPHPSYNAPAPTGPAQYNFDWSVNDANSGNDYGHNEGRNGYDTQGSYYVQLPDGRLQRVTYTVNGDSGYVAQVEYEGEAQYSAYQPAPSYQPAPAYRPAPTYTPTPSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUH1</accession>
    <name>A0A8J5MUH1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oplophorus-luciferin 2-monooxygenase non-catalytic subunit-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Lucb-L12</name>
        <name evidence="5" type="ORF">Hamer_G020539</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025733">
        <property type="protein sequence ID" value="KAG7164091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUH1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF161">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7164091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="479" mass="52604" checksum="2568BD8599FD473D" modified="2022-05-25" version="1">MVRFGEEELRPRYKSGEESEGSEESEGSEESEGSEESEGSEESEGSEESEGSEESEDSEESEGSEESEGSEESEGSEESEGSEESIYCAWVYNRVSGSVSTTYLTMTFFHYFLCLLLMVTSCVGSTVDTSGDNVQAAHDHTVGHVGNPLTDVVGLEVSDTDPVCPDPGAIFPCNCTMDYHFNMDLDCSYVESEDQLARIMNVSFPTPDFHRLTIYGNHNLKELRAGVLGETATFQEIWMIFGALQEVEEGALANSYSTATDIMFTSNSIDKFCWNDISSFSNLHKLSLPSNNLAHITKMSSNSLHLLSLGKNDIRSLPLTAFRAMPNLQKIFLPNAGIEEIIPDTFSGLHELSVVDLSHNQLQELPGGTLALTSKSHHEIYFDNNNIGKVAANAFSGLMSGDNMSWNSNQLTVLESQVWRPLLDAGVKLDLQDNPLGCGCDISWLVLNADYLSLINDGTTCSDGEIFVDLDPNWFKENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUP3</accession>
    <name>A0A8J5MUP3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026055">
        <property type="protein sequence ID" value="KAG7164002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUP3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="547" mass="59650" checksum="C58140E3DE1F769D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUP7</accession>
    <name>A0A8J5MUP7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUP7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="212" mass="24173" checksum="30B9D38F66CF90EA" modified="2022-05-25" version="1">MVVMASKRSFRDAWLNNEDFQPWLSRVEDNPSRAFCKICKREGIDNKSKKEMPALDDFVKVVPRIYSGSIQVLDDQWRDLDVIATPPEIKDSSDTVDVYTKQGELKGDEDTVPESSKVDVSGERNSVFCRYCKQTDHVIAKCRKSSLDTIPLAKADGRPVLHINVVPNTVEIFDPRTSANLIQCAHILELSLLVYHLHLDHFTRNVSYPIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW10</accession>
    <name>A0A8J5MW10_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sex combs reduced-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Hamer_G005652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022531">
        <property type="protein sequence ID" value="KAG7166535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW10"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7166535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="222" mass="21305" checksum="C964EB5AC99F44B4" modified="2022-05-25" version="1">MSSYQFVNSMSACYGQRGQDASVVNTDYYGTSLNSYNNCYSPPLQYGGYTPSGISVVPNGSEFSGGGSSGASGTSASAASGSSVGTPSGSGGNTTPGPSVQGRLHQTSSSPASTPQASTSSASCKFASTPESSANPVGSPQDLSVSAGGSGPGSSSSGSGSEQNSSSQGGGGGTSTSAGGGEGAEGGESLEGASGSSGGSSSTKSQPHIYPWMKRVHLGQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWH1</accession>
    <name>A0A8J5MWH1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted RxLR effector protein 78-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RXLR78-L2</name>
        <name evidence="2" type="ORF">Hamer_G005388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWH1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="203" mass="22600" checksum="8C47405388B876AF" modified="2022-05-25" version="1">MANDWWVKKAQEIQAFADVHNTHGFYEAVKSIYGPQRRNVTPVRSLDGPTLYKINQMIATHDGMQARVLVGGVQSEPFSVQMGVKQGCVLSPVLFNIFLLAEAQLSHNALGPDAGVGIRYRLDGNLFNIRRLEAYTKTLTTQAIELQYADDCVIMTHNRESMQRALDVISGLDSIVIYGGIRGITQLINHLIWSNVVNFDGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWQ3</accession>
    <name>A0A8J5MWQ3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G019887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022770">
        <property type="protein sequence ID" value="KAG7166102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWQ3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="109" mass="12825" checksum="CF6E0C677E005AEF" modified="2022-05-25" version="1">MFLGMCDNVEDQMSLVEPNYDAREMMMGLLNKIRGHYQEKYNKKVNDSKQDLITRYLSHKQEENKQVIEAIEHLEVEDEGEDRHGLASLPENLYLERFHRVVEEGGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXA1</accession>
    <name>A0A8J5MXA1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Txnl4a-L</name>
        <name evidence="8" type="ORF">Hamer_G005407</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays a role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).</text>
    </comment>
    <comment type="function">
        <text evidence="6">Plays role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U5 snRNP complex. Component of the U4/U6-U5 tri-snRNP complex. The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Directly interacts with CD2BP2. Interacts with HNRPF, HNRPH2, NEDD9 and PQBP1. Interacts with ERBB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXA1"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035189014" description="Thioredoxin-like protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00058660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00065304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7167076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="133" mass="15656" checksum="972932FF77F81827" modified="2022-05-25" version="1">MSGCKKYLISAFIHLLTVIRFGHDWDPTCMKMDEVLYNIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTCMFFFRNKHIMIDLGTGNNNKINWALEDKQEMIDIVETVYRGARKGRGLVVSPKDYSTKYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXX5</accession>
    <name>A0A8J5MXX5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G005404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXX5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="109" mass="11597" checksum="923272871AFEAE3B" modified="2022-05-25" version="1" fragment="single">MGLRFSHFFQIVRLRGERLTEVNVWLVENSSKQTPHKVKHFHSAIGVQCPDCQHLEYKPLQTPPSASASTQVPYQSASPGTNASPGTNASPGTNASPGTNASPGTNASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYG0</accession>
    <name>A0A8J5MYG0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cc8K15.2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYG0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="87518" checksum="A96B43AA3B1D17DD" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZN5</accession>
    <name>A0A8J5MZN5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017295">
        <property type="protein sequence ID" value="KAG7169326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZN5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361:SF2">
        <property type="entry name" value="DUF885 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="GLR0591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="186" mass="21480" checksum="F0FD2614B32C48D8" modified="2022-05-25" version="1" fragment="single">RLKIQFFEVFLSCGVELQLKKLLLQFIRNISYFTLKWVPDEFPAFTLLIYLWEVSDEFCFQIFRASRLVVDTGLHALGWTRQEAVDYLINHTAMPTVKVENEVDRYITMPGQALAYKVGQLKLMDLRYKAASVLGDEFDIKKFHDVVLDSVGPLDLVEDEVNAWVNAGGKKLDVVRVIQCIKLWSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0V4</accession>
    <name>A0A8J5N0V4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Krueppel 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Kr-h2-L</name>
        <name evidence="7" type="ORF">Hamer_G019905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012835">
        <property type="protein sequence ID" value="KAG7171170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0V4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7171170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="255" mass="29256" checksum="435EAAA052B17C03" modified="2022-05-25" version="1">MTDEQQNEQPQEERPRVGSVESLKTHVLEHKVDMALWATRALTLVFCISYLIPIFGNPHSSYQKVLMSNAATSALRLHQRIPSVHLSREFIAQLLMEDSAHYLLYSLIFMYTSPVTMVLAPIFLFALLHFASYSLGLLDVSQNNALGSRFLISLVEFQHRNILRGAAFVEIFLMPLTVVLLFLGRVSLLTPFVYYRFLTLRYSSRRNPYTRNMFHELRMTMEYTVNKPGIPVFLRNAVNRAIIFLSGLAPAVVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1Q9</accession>
    <name>A0A8J5N1Q9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1Q9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035158191" evidence="1">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="7389" checksum="D136F9786ABBD4C2" modified="2022-05-25" version="1">MSTKILSLVLGGLALSFFLTIIGNAMEAVNGTCRKLKCEAGEVVMNMCDGGCACCVQSKWLSSINAITDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2W9</accession>
    <name>A0A8J5N2W9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ileal sodium/bile acid cotransporter-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Slc10A2-L3</name>
        <name evidence="9" type="ORF">Hamer_G009656</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2W9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF28">
        <property type="entry name" value="P3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035274347" evidence="8">
        <location>
            <begin position="21"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7172297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="417" mass="46603" checksum="3585FEC5C275539E" modified="2022-05-25" version="1">MMSLTMTFLLMAWVSGTVNGIAGGTMGDAEGNSADSGVYLEVFPSAEWKVPEDTLHHLTLSLGFNENDTYCDGGQDLTEAQLVVTVVPDEDWKLDFVNRSIHFTVEEVCDHVNKSLTFSGYYWGLTKLSFYLTTNYHLLHLYNNTLLRDDVLITVDRKTYVLDFVFIIFGATFVLVNNINMGAQLELQIIKAVLRRPLGPVCGFISQFAFMPLFSFIMGKIFFEDPLQRLGLFTLGCSPGGTSSNFWTLMFDGDINLSITMTAISTIAAMGMMPLWMFTLGKKLLEDNANLQIPYSNLALSLVSLTVPVGIGMFIRFKRPVWADRGRRIIKPFTLIVILFFLTLGIYNSYKVFTMMTWQMVVAGLLVAICGYSFGAIFAKLWCLPRDKVIAISIETALQNPGVSFILLKLSLPSPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N399</accession>
    <name>A0A8J5N399_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010646">
        <property type="protein sequence ID" value="KAG7172537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N399"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="143" mass="16635" checksum="7E2825EC29E14AFB" modified="2022-05-25" version="1" fragment="single">MILPLLHQWTKANALFKPPVINQCRTIELKLTKLWHNAVETSLGKRENNSHIDCGCPREKKIPVLELEFIKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDSSSDEQEATSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N457</accession>
    <name>A0A8J5N457_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin carboxyl-terminal hydrolase 19-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Usp19-L</name>
        <name evidence="3" type="ORF">Hamer_G017866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010216">
        <property type="protein sequence ID" value="KAG7172887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N457"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="2">
        <location>
            <begin position="138"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="296" mass="32968" checksum="DBF57D187663B96B" modified="2022-05-25" version="1">MPGNSVSNDLAHDWMQKNEFVIVSVWVGQGHDNRTVNINTDETELTVSLPDGRKFSTQLFETVLPEATSMSYKGARCIVKLLKSDPNIHWPHLEPAKKPTPEKIISTKAKSSSLSPGKTPEKKPAEVDNKVDNNTVCVSNVKIDYMERDAESLIVVFLYIKNINKETSFVTFTEDSISASFSTSDGRFLQQYSGSTEDTVFEWDLTLKDKVVLEDCKFKVNPNNIEIKLKKQNNKKWGALTAVTPDSAASNKVAKNMWMAASKTETPTLSNIPPAPPIPPSMENKVLYSTMYTSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4Q5</accession>
    <name>A0A8J5N4Q5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010089">
        <property type="protein sequence ID" value="KAG7173316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4Q5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="278" mass="28951" checksum="1CDAD086B2827663" modified="2022-05-25" version="1">MDGGGGFVRAGLLGLTQGVSLHDPLRLHHALHTQASDSVKDGTSTTSLLRPLSDYPHLPLLPFTAPPFLHPHLDPRLPFSPSAFHPLHSHAHEAHARAHDAHAKLPPPPTGSLSGSAFSPLPAKTAKMEDGGCSSSVIPCSSSGLFSPALLASLDPRTAFLTGGGGGGGGGGGGGLGLLEDRRDSPSPRGSHGSRESPGHARDTDTPNSNSDEPKGGGRLQPSRADYATDVWAGENVGWQPPALTMSIKADPKGWKLPQCHTRLKGCHGLWWQNVENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4S5</accession>
    <name>A0A8J5N4S5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rps2-L</name>
        <name evidence="10" type="ORF">Hamer_G023462</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009918">
        <property type="protein sequence ID" value="KAG7173437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4S5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="93"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7173437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="281" mass="31028" checksum="24D3FF2D859D9A69" modified="2022-05-25" version="1">MPTKIKVVLMADSGSGRGGFRGGFGTRGRGRGRGRGRGRGRGRGKENEKEWVPITKLGRLVKDGKIRSLEEIYLFSLPIKEFEIIDFFLAPQLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDFNGHIGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTVPCKVTGKCGSVLVRLIPAPRGTSIVAASVPKKLLQMAGIEDCYTSARGQTATLGNFAKATYAAIAKTYAYLTPDLWKETVFTKSPYQEFTDYLAKYHKISSEQRQETKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N511</accession>
    <name>A0A8J5N511_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009549">
        <property type="protein sequence ID" value="KAG7173541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N511"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="94" mass="10246" checksum="9C455A1DDB37920C" modified="2022-05-25" version="1">MGSTTHCSGTPFRCDLPDQGMKKGSAEGSPRQSSVAVSWVRAVHLGRLRGVATYQRRGPDRRSKKNSGPYQSREPDHGPGRGALFPLRGIGRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N647</accession>
    <name>A0A8J5N647_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G022822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008466">
        <property type="protein sequence ID" value="KAG7173953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N647"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36911:SF1">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36911">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
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        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="822"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="987"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7173953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1074" mass="119125" checksum="45862626939D08DF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6H2</accession>
    <name>A0A8J5N6H2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="9">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">IDH2-L</name>
        <name evidence="15" type="ORF">Hamer_G020136</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9 12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9 12">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010009549">
        <property type="protein sequence ID" value="KAG7173513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6H2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="14">
        <location>
            <begin position="1"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="77"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="276"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="10">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="10">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7173513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="377" mass="42612" checksum="031F7F65D07C6438" modified="2022-05-25" version="1">MTRIIWENIKESLIFPYLKIDCKYYDLGLPYRDQTDDQVTIDSALAIKKYNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPILCQNIPRLVPGWTQSIVIGRHAHGDQYKATDVELVYTPDGGQAQRMKVFDFKNGGGVAMAMYNTDESINSFAHSSFQVALTKGWPLYMSTKNTILKRYDGRFKDIFEEVYQAEYKKHFDAKGIWYEHRLIDDMVAQALKSTGGFVWACKNYDGDVQSDIVAQGYVLMCPDGKTIESEAAHGTVTRHYREHQKGNKTSTNPVASIFAWTQGLEHRAKLDGTPELARFAQSLEKACVDTIGAGHMTKDLAGCIHGIKNVKEGMYLYTNDFLEAVREDLAKKMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6M3</accession>
    <name>A0A8J5N6M3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G020223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009370">
        <property type="protein sequence ID" value="KAG7173588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6M3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="110" mass="12157" checksum="16530994FB210D0A" modified="2022-05-25" version="1">MSRRVNTRDDIAAVIALYKANHELRNTSALAGVGLHGVQKLVKRYCELGEDMLPASLPKSGGPKFLFPRTLEVISPQVKSNPALTTRKVKYRNPQSSQPRLLTLCSTSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6P4</accession>
    <name>A0A8J5N6P4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007950">
        <property type="protein sequence ID" value="KAG7174100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489">
        <property type="entry name" value="PROTEIN-COUPLED RECEPTOR GPR1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="135"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="151"/>
            <end position="170"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="211"/>
            <end position="290"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="322"/>
            <end position="375"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="432"/>
            <end position="459"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="480"/>
            <end position="504"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="588"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="846"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="622"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="751"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="765"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="860"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1352" mass="146554" checksum="C83F012F662D196D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7S1</accession>
    <name>A0A8J5N7S1_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7S1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="215" mass="24531" checksum="2BA800377228942A" modified="2022-05-25" version="1">MANAVNFLVKTWRNTTKATVWHAWSALLPQLKSAETKRQQPAELMNQVLETVRSIPAPGFQEVTREDLEELIQEGNTNDVEDLLEDEEGGESGDAESDAGETEQRKVTTQKLSLLLGVCTSPQEMIQDIESDSGEREQMIGFVESISRKYQKQYNERVNARQQSLITRFLSQRWPAEEDQQREVEDDEDIDGIREMPEDFDFTGFDEVLAESDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8K5</accession>
    <name>A0A8J5N8K5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Beta-4C adrenergic receptor-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Adrb4c-L2</name>
        <name evidence="14" type="ORF">Hamer_G015133</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7174934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6376512at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035186071" evidence="12">
        <location>
            <begin position="27"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="709"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="746"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="466"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="28"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="152"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7174934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="827" mass="92539" checksum="64E9F693779904FD" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8M7</accession>
    <name>A0A8J5N8M7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450 6a2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Cyp6a2-L</name>
        <name evidence="15" type="ORF">Hamer_G025071</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004517">
        <property type="protein sequence ID" value="KAG7175941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8M7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="303"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7175941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="391" mass="44654" checksum="7980FF31F18C66BD" modified="2022-05-25" version="1">MGMEAWLLTVVGVLGSWLLIVMGVEVWILLMVGVMGSWAYTRRRHNYWSARGVSTPPYLPFLGHLHKLFSPTQSKQLYFWEIYHKYGGARFCGLYELHNPLLLIGDPHLIKHICVKDFDHFVNRRGIGTFNNNNVVNLMLFNKMGGEWKALRSVMSPTFTSGKMHVMFPLICEKADALVSFSLKQSAEKYYTDMKYNFACFTIETIASCAFGVDCDSKDDEIRNFAKQADKLFYFSFTSIMKIALRRIFPKLSSALGLTRERPEFLFFKNVAKKAIQLRQEGQRRGDFLDLLLEASATDEPSITHKKNLTIQNNDHTAQNNDHTTQNNDHTTQNNDHTTQNNNQHINDQTQAPSKDGKTNLGYCECVKPNLPHQSALMGSLLLAEKHIFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9Q0</accession>
    <name>A0A8J5N9Q0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein zwilch</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">zwilch-L</name>
        <name evidence="10" type="ORF">Hamer_G001440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the RZZ complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Chromosome</location>
            <location evidence="1 9">Centromere</location>
            <location evidence="1 9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ZWILCH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9Q0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018630">
        <property type="entry name" value="Zwilch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15995">
        <property type="entry name" value="PROTEIN ZWILCH HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15995:SF1">
        <property type="entry name" value="PROTEIN ZWILCH HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09817">
        <property type="entry name" value="Zwilch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7175369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="574" mass="64860" checksum="F6D8677AC3A1B7CD" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9T2</accession>
    <name>A0A8J5N9T2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytokine-dependent hematopoietic cell linker-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Clnk-L</name>
        <name evidence="5" type="ORF">Hamer_G001485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9T2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051751">
        <property type="entry name" value="Immunoreceptor_sig_adapters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14098">
        <property type="entry name" value="SH2 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14098:SF14">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="359"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7175403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="477" mass="52538" checksum="71F3F7A05B4DBAE7" modified="2022-05-25" version="1">MVCLPDNGGLGAAIFTAPLLLVRGLGRRAAHWIVINHQRHLQKLSVRRRHRQSLSQKARPCSQPLVSRTSHDCKIRPQSEPVPCTHHSQASFSNTSPATAHLDDIPAEQEVDVHVTGIHLPVEPLIVICNHSQSTYESSYLPGERLHTLRGTCFLRVPPFNHSCSVGQYHQDDAALLPHTASADGRDAGNRQGQGIGTQQPPVGYNISPGQVHGTAAGNSKWQVGADQGSLTKKEKWPPVPIPSHHTPSSLLRQPESSEGSRLGAGRSPTPEPLLPPSGHLSSGHPSGHAEQYPGPSHQANDCYIQFDQVPKEMAPPPPPESSPQLASRVRGATQEKIRLIGGDSIELLPLYRVLIEQPYFHVISRGKSMNILENASDGMFLIRPSTRSKDPLTLCLRHGGRTYNINIRHRSDGLFALGFEKTNEMTFSSVEDIINTHRREPIKLQNGERAMLTVSPRKSEHIYVQITNSRQMELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAM3</accession>
    <name>A0A8J5NAM3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc finger protein 56-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Znf56-L3</name>
        <name evidence="2" type="ORF">Hamer_G009948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAM3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="229" mass="25465" checksum="716505A068017C83" modified="2022-05-25" version="1">MLVHRNMAPRPEDSPVSTPRTRSPVKGVRTGGVSCAGPDALSMLNMLAEVASVTLHTDPSVTDSNPTYKAKASSAASRKPSDYELLTLEHVAGMTDNLLVKLFAEFESNEMWKRFTYTCGMLPAACSKYFQSFGSEHKARAGMKSHLQTHLKSLMEVHKMEVWETLGDDGGLRQGVKASRIQNQLQTQVKRLQLHHQSSEQQGHHHWILLELLMRKIGTDESLAAVFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NB00</accession>
    <name>A0A8J5NB00_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NB00"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057456">
        <property type="entry name" value="Znf_C17orf113"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25431">
        <property type="entry name" value="zf-C17orf113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="C17orf113 probable zinc finger" evidence="1">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="125" mass="15218" checksum="353D2D6ED43658A3" modified="2022-05-25" version="1">MWRVIKDDLEFQLQERWIHYNNEQQRERYRKYDATRRSRNFVQNWKFEFEWVYYDTKLKVMTCTTCIKYGTEEDKKSRFVSGNTNFKRLALVRHQRSQVHRRCETRRIADLGLCIPAAADGATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBT0</accession>
    <name>A0A8J5NBT0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Casein kinase I isoform gamma-1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Csnk1g1-L2</name>
        <name evidence="3" type="ORF">Hamer_G027496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001548">
        <property type="protein sequence ID" value="KAG7177861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBT0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="152"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="381" mass="41983" checksum="B3AEF73DA94B2831" modified="2022-05-25" version="1">MMWQCCCQPGRRVGDDVVVLSSQGGGRDDVVVLSSPGEEVGDDVVVLSVRRRKVRRVLGCKTRRDDPPAPVEVSPEDLTTSSPLLSNHSSPHSSPHSPDSSTPSPMPSSHSPMPSSHSPMPSSHSPMPSSHSPDISNQFSFTWLSSDELQKIPLITVIREGKYGLIYLAVYNKELAVMKMYIKENQECFLNEMAAHISLNGIAGAPRLYAACPEAYALLLEYTGIPLEDYFSCCTLRKKLEVLIKIAERLGELHKKNIIHNNLKPHSITLTFQGEEPIIHLIDYRVASETGCLEKGNSLRRCKNPGYWLAPEFGKGGVPSPTTDTYSFAHLVIDVKNQIFHPLLQECLRMVAGATCGLNPLHRAPLPEVIGLIRSFLPLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NC90</accession>
    <name>A0A8J5NC90_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine protease 45-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PRSS45-L1</name>
        <name evidence="4" type="ORF">Hamer_G025319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002814">
        <property type="protein sequence ID" value="KAG7176754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NC90"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7176754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="185" mass="20423" checksum="5C51391AF170D227" modified="2022-05-25" version="1">MPVDYEIEEIIVHPGYEPDSHIQYNDIALLKTVDKIIFNDLIFPYCVSDQTPAPNTIVTGSGFGLANATHQSSMLQEAELRILDSAECENIYRREHHEPQLRVVYPDLLQGRDIMCANHPERSACEGDSGGPLFLDVADGRRFLVGMVGSGVACRGGGASILPDLFVNLAHHITFIDKEIFGNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCE3</accession>
    <name>A0A8J5NCE3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCE3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="82" mass="9086" checksum="AAE5167B6DD3AD2A" modified="2022-05-25" version="1">MIGGDSANTNMGWSGDTIALLEKMLGRKCHWMICQLHVNELPMRHLIIKLDGPVTPQSGFSGPIGKLLEKVNELEVNFKPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCK2</accession>
    <name>A0A8J5NCK2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCK2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="189" mass="21530" checksum="5ED7DBD1EBE11182" modified="2022-05-25" version="1">MVEDQAHQSTLLDYYHVTAESAAQIQSYKSCDPFQHLYKYKEMANQYIPKTSIVQQRENISEAMGTLQKDCQPSPRSADPVDQGYETLFDKRYKSNHFHGPGGWIADFSAGKQALMSWNQEDIEDVLASHTEELTNEDLQQLTENSPVVDEDNGEEPQRTQAPERKAEAFNMMQQGLKPGHTSDDLLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDN5</accession>
    <name>A0A8J5NDN5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDN5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="128" mass="13579" checksum="27F83B0C520EA35A" modified="2022-05-25" version="1">MVTPLVTAATAAGEGHPGTGQRGSGVNHPAAADGHEHLGSCATTWWRRQVAWSGGGRRRGAATAGGVERWLRRRLRRRASGARQQQDFHVLLPGSVTSSPPWPLSSPALWALISKLWDGDMGGGVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NE11</accession>
    <name>A0A8J5NE11_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 54-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">VPS54-L1</name>
        <name evidence="9" type="ORF">Hamer_G008168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NE11"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="8">
        <location>
            <begin position="175"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7177534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="711" mass="80408" checksum="8520D8ABAC36712C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NEA3</accession>
    <name>A0A8J5NEA3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">med6-L</name>
        <name evidence="6" type="synonym">MED6</name>
        <name evidence="8" type="ORF">Hamer_G003779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NEA3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7178027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="232" mass="27101" checksum="8078984B5B56263E" modified="2022-05-25" version="1">MADQSKENPLHISWHDSMWVPHLNSSNIMEYFGERTNPFYSRECNNEFIKMQQNTREPILYIIRKQQRYSPTQVSPLANYHIIGGQVFQTPDLGSVINSRTLAAVSNLNSAFTEMQSFSQYHPSRGYWWQFRNQVEQTEQQKKEKEKKAQQPAQQPTQQPAQQPQQQQQQQQQPSQQQTPQQDTIKTEDNKPDIKTEIKTEVKIEIKTEPSSQPPTPRSVKPPPEKRQRTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T317</accession>
    <name>A0A8J5T317_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Transposase-containing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G009703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T317"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="216" mass="25087" checksum="F193F924506A9068" modified="2022-05-25" version="1" fragment="single">KTYNLESQLGDKILYSLRRILNRDKADEISSRKNKITCREGCPVMRDVKTLGLLASGDIWQLSTHHEMSRRVTTRDDIAAVIALYKANHVLREISAQTGVALRVVQNLVKRFRDLGEDELPALSLVGLNYCLHGHLRLFLDKFGPIPHSQHRETPVLLRCVQQALHDDLGFKSFHARRKPLLTKRQKENRVKFCKKYEVWDLETWRSVLWSDEATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T3C9</accession>
    <name>A0A8J5T3C9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cuticle protein 7-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Cu7-L5</name>
        <name evidence="4" type="ORF">Hamer_G026380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010910">
        <property type="protein sequence ID" value="KAG7172484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T3C9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="328"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7172484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="440" mass="49360" checksum="8FC88F25ACC93C84" modified="2022-05-25" version="1">MWGRGRDVGPGRGCGGRGRGCGGAWGEDVGRGRGCGRAWEGCGRAWERMWGRGRGCGGAWRGCGDVGEELRLTVTQLLATPLSRHIHLTPSYFTSSTTFGILISNMKVKSPTGTTRPRRPQHHHDHDDSYRLCGNTVCEHDNNEDEDKDEEEQQQKEQRQDEEDDLAINNEKEEAINKQEDLHHFTKPATTSLLSQVPSLLLAVVVILGVYHTSALHQVELEYVDPIQLSTFDGYRIGNNFGLGGYSSFFYSLPTSFRSEQRTASGEVTGEYAFVAPEGKEFQFKYQAGDEGFRVESDALPVAPEDTEEVKKAKEEFFAAYQKALEMAGSYEEEDGDSSDESSEEHYYEESSEEDGDDDSDESDESDESDESDESDESDEEEEGEEEGEENEEEEENEEEGEEEKEGKTGGRIFAPFQSISRNIGFGQRLRRPYPYTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T559</accession>
    <name>A0A8J5T559_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neuroparsin 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Np1-L</name>
        <name evidence="2" type="ORF">Hamer_G006953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T559"/>
    <dbReference type="OrthoDB" id="5976811at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010850">
        <property type="entry name" value="Neuroparsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07327">
        <property type="entry name" value="Neuroparsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035265754" evidence="1">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="98" mass="10585" checksum="6C99A6BA26ACEBC0" modified="2022-05-25" version="1">MRSDILFTIVIVSIFFFNISEAAPSCDGHGTRTEPTDCDYGSFQDWCGNNVCAKGPGQRCGGEWWENDDCGHGMYCANCGNCAGCSVGIQCWFCDSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T841</accession>
    <name>A0A8J5T841_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4789 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G020027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008712">
        <property type="protein sequence ID" value="KAG7173879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T841"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031993">
        <property type="entry name" value="DUF4789"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21177:SF7">
        <property type="entry name" value="GH11627P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21177">
        <property type="entry name" value="IP06524P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16033">
        <property type="entry name" value="DUF4789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4789" evidence="2">
        <location>
            <begin position="335"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7173879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="926" mass="102496" checksum="AF4828A89C317C34" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T9M5</accession>
    <name>A0A8J5T9M5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cuticle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G025914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009687">
        <property type="protein sequence ID" value="KAG7173490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T9M5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035145120" evidence="4">
        <location>
            <begin position="17"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7173490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="164" mass="17354" checksum="73C316C8350E3BDC" modified="2022-05-25" version="1">MFSKLVLCVLLALVAAKPQEGYGAPQPSYTSSGPVVPIVKDERQGPDADGNYNFDFETGDGISRQEQGAPHGETGAVAAQGGWASPAEDSVSHTHFFFRFKFPDGSPGVFNFVADAAGYKVQSDLLPTPHPLPAHAIQQIEFARQQGAAGPRPQYGAPPTPGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIT5</accession>
    <name>A0A8J5TIT5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">msantd4-L2</name>
        <name evidence="5" type="ORF">Hamer_G022775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010337">
        <property type="protein sequence ID" value="KAG7172847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIT5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF16">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7172847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="102" mass="12044" checksum="1C35C875ED4F3248" modified="2022-05-25" version="1">MDNKPHLKRRPNFSEAEKIMLVKEVMKRRKVLLGKSESIVPMRLRMEAWDSIASAINGVNPAVRQRERNELKKKFTDFKSSVKKDLERRRKALLRGIHTVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TL20</accession>
    <name>A0A8J5TL20_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Glutamate receptor-like 46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Glrk-L46</name>
        <name evidence="20" type="ORF">Hamer_G015381</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TL20"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035267362" evidence="17">
        <location>
            <begin position="19"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="18">
        <location>
            <begin position="81"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="19">
        <location>
            <begin position="91"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="396"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG7176580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="533" mass="59425" checksum="4B10DFFB541CCCF8" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TL45</accession>
    <name>A0A8J5TL45_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Low-density lipoprotein receptor-related protein 2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">Lrp2-L1</name>
        <name evidence="26" type="ORF">Hamer_G003270</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Endosome lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <location evidence="18">Coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031904">
        <property type="term" value="C:endosome lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000155">
        <property type="entry name" value="Low-density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000189">
        <property type="entry name" value="low-density lipoprotein receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000181">
        <property type="entry name" value="Low-density lipoprotein RecePtor related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000230">
        <property type="entry name" value="Low-density lipoprotein RecePtor related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000002">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000011">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000005">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000035">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000045">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000119">
        <property type="entry name" value="Suppressor of tumorigenicity 14 protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000062">
        <property type="entry name" value="Terribly reduced optic lobes, isoform AI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056588">
        <property type="entry name" value="EGF_LRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032485">
        <property type="entry name" value="LRP1-like_beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16472">
        <property type="entry name" value="DUF5050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24468">
        <property type="entry name" value="EGF_LRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="38"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0168">Coated pit</keyword>
    <keyword evidence="14 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 20" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="26" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15 26" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="4385"/>
            <end position="4406"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="282"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="22">
        <location>
            <begin position="501"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="22">
        <location>
            <begin position="694"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="22">
        <location>
            <begin position="824"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="22">
        <location>
            <begin position="1467"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="22">
        <location>
            <begin position="1512"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="22">
        <location>
            <begin position="1556"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="1646"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="22">
        <location>
            <begin position="2153"/>
            <end position="2196"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="22">
        <location>
            <begin position="2197"/>
            <end position="2238"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="22">
        <location>
            <begin position="2426"/>
            <end position="2466"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="22">
        <location>
            <begin position="2467"/>
            <end position="2513"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="22">
        <location>
            <begin position="2514"/>
            <end position="2555"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="3068"/>
            <end position="3109"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="22">
        <location>
            <begin position="3198"/>
            <end position="3240"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="22">
        <location>
            <begin position="3241"/>
            <end position="3283"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="22">
        <location>
            <begin position="3330"/>
            <end position="3373"/>
        </location>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TN26</accession>
    <name>A0A8J5TN26_HOMAM</name>
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            <fullName evidence="2">Regulatory protein zeste</fullName>
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        <name evidence="5" type="primary">Msantd-L28</name>
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            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">GMGI-L3</strain>
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    </reference>
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        <text evidence="3">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
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        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
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    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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            <end position="83"/>
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    </feature>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TQC4</accession>
    <name>A0A8J5TQC4_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Actin cytoskeleton-regulatory complex protein pan1-like 2</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="primary">pan1-L2</name>
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    </gene>
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        <name type="scientific">Homarus americanus</name>
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        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003350">
        <property type="protein sequence ID" value="KAG7176477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A8J5TQC4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="420" mass="47411" checksum="1FF8A674FA1E7CCD" modified="2022-05-25" version="1">MKQGQLAITTHHGAAADTFTIVCLGVQVYLLQPRTRHLLQPTSCSLGVPPCSLETRAYLLQPKRPEYTSQQPKRPEHSLQPRRLEPSLQPGDQSIPPCNRGDQSIPPCSLRDQSIPPSSPEYASCSLVDQSIPPAADQSIPPLQPRRPEYTSCSKGDQSMPPWETRTSLQPRRPEYTSLQQPRRPEYTSLQPRRPEYTSLQPRRPKYTSLQPRRPEHTYLQPRRPEYTSLQPRRPEYTSLQARRPEYTSLQPRRPEYTSLQPRRPEYTSLQPRRPEYTSLHGRNGVAGCRGAPGRPPRTYTLYTSEDDQPIQDPPRRQRCHLGWVAWCADAITQLEQTLTPCALCKGLSHTEATTTSAQRAGCHTATRDDRRHHHHHGLSSTTTRTSPAAAAADTDPACLPQCGLNKPTLLLLTWTTSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TUB6</accession>
    <name>A0A8J5TUB6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TUB6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25884" checksum="AA91C894B8F72579" modified="2022-05-25" version="1">MRLNKYTKGPAAGLLNGTRTFKVNLKNNIPSSVTEGGHSLTFLYAGQRKTYYKCGHEGHLAIDCHTEEVDKVNIFNEEDFPAIQLSGEIHNSRADKEEENVAVIQVPATTRHGVEREEVPVQTISQDAVDLDGTTHPDCSENAAQETSTTCEAEIHTDRNNADQTKGKISFENMEYDKADDMEATNMIGTECEVARGENMDRMEEIVEVTCIMSPSRNTNDANKKDQNKTGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J869</accession>
    <name>A0A8J5J869_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G024816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045833">
        <property type="protein sequence ID" value="KAG7154036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J869"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="67" mass="7531" checksum="7947717C99671AFF" modified="2022-05-25" version="1">MYVLVASPKYDILVTPPRCNVLVTPPRRNVLVVPPRCNVLVAPRRCYVLVAPPRCDAFVTPPRRMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JA48</accession>
    <name>A0A8J5JA48_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cathepsin B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Ctsb-L</name>
        <name evidence="9" type="ORF">Hamer_G009404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JA48"/>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000031">
        <property type="entry name" value="Cathepsin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012599">
        <property type="entry name" value="Propeptide_C1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08127">
        <property type="entry name" value="Propeptide_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035249645" evidence="7">
        <location>
            <begin position="19"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="81"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7153734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="333" mass="36919" checksum="95D41260C58EB1C8" modified="2022-05-25" version="1">MMKLVVAGLVLVVVVAVAGDYALSDKFIRLLQSEESTWKAGRNFNKNLPMRYIRRLMGVHPDSKYHMPRVHRHEIPENFELPNEFDSRTAWSMCPTIGEIRDQGSCGSCWAFGAVESMSDRVCIHSKGKENFHFSAEDLVSCCHICGFGCEGGFPGAAFKYWVTSGIVSGGSFNSTQGCQPYEIAPCEHHVKGSRPKCSEGGTTPKCVRQCESSYTVDYESDLHHGSKAYAISKDVEQIQYEIMTNGPVEGAFTVYVDFLHYKSGVYQHRHGLPLGGHAIRVLGWGEENGTSYWLCANSWNTDWGDNGLFKILRGSDHCGIESEIAAGLPKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JBU8</accession>
    <name>A0A8J5JBU8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044465">
        <property type="protein sequence ID" value="KAG7154349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JBU8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="97" mass="10688" checksum="EDFC9504B1FCBCDB" modified="2022-05-25" version="1" fragment="single">STDSPCVPLHTMRLRRIRRSDAGLYVQRPTGLVRYCARKLQTVDKSPKLGRCTRQLDECAAENRGLSGAATASSEDDAREEQRTHPHSAAAYGTLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDV9</accession>
    <name>A0A8J5JDV9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative VsaC1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042688">
        <property type="protein sequence ID" value="KAG7155189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDV9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="511" mass="55243" checksum="397E7BBB5ECBB98C" modified="2022-05-25" version="1" fragment="single">AVNTCQHLSAAVNTCQYLSAAVNTCQHLSAVVNTCQHLSAAVNTCCQAAANTANTYQLPTLWPTILSAQSTPATYQLPSTPANTYQLVAQHLPTFISSWVNTCQHLSAVVNNTSQHSTSAPVNTCQHLSAPRQHLQANTYQLSSTPNTYQLSSTLVNTYQLPSTPANTYQLSSTPATYQPRQHLPTRSLPHQHLPTLIRLPSTPANTYQLPSTPAISFYQLSSTPTLSAPCRTANTALSAVVNTCQHLSDANTQANTYQMPLTPANTYQLPSRPANTYQLSSTPAGFVVNTCQHLSAPPTLQHHSITCRQHLPTLISRRHTCHLYQPLSTPATLISCRQHQHLSAPNTCQHLSAPVNTCQHLTAVVNTCQHLSDAVNTCQHLSDAVNTCQHLSAAVNTCQHLSAVVNTCQHLSDAVNTFQHLSAVVSTAALIQIPSARSTYQMPSTPANTYQMPSTPANTYQMPLTPANTYQLPSTPANTYQLSSTPANTYQIPSTPANISSRESNPINIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JF41</accession>
    <name>A0A8J5JF41_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450 6k1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Cyp6K1-L2</name>
        <name evidence="14" type="ORF">Hamer_G025699</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042530">
        <property type="protein sequence ID" value="KAG7155223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JF41"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035213418" evidence="13">
        <location>
            <begin position="16"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7155223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="440" mass="50527" checksum="DFED06F3F111D919" modified="2022-05-25" version="1">MLFTVALLVVTLVTAAWLYSKYCHNYWAARGVVTIPGYIPFLGHSHKLYRTSYPRWLYIDEVYKNLAESKFCGYYEQLTPTFMLMDPELVKTILIKDFDHFVDRRHIRLTSKRDGVFTEMLTTINGDHWKGIRSVVSPTFSSGRMKGIFPLVALKADALVDYIHRQIKSHSALPLQKTFALFALEVISSCAFGMETNAFECGGETTFNVMVEKLFAVSFFRKIKLFLYLLSPRITSFFKISLTAPEIVFFENVIMETMKQREKGGKRGDFLDLMMEAREDQKDPNLKAPKYPLKDATIVANSILFILAGYETTATTLSFVAFLLAQHPEQQQRLRQELENIVKEYGTLTYQGIMEAKFLDACISGMRFALMETKLALAKTFLEFEVSCAPGQEQMEFAKEIRIMKPSPDMKIVFKPLINCEQELARRDCDFSHTVAKEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFP0</accession>
    <name>A0A8J5JFP0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Transposable element Tc1 transposase-like 59</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tc1a-L59</name>
        <name evidence="4" type="ORF">Hamer_G025851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037585">
        <property type="protein sequence ID" value="KAG7157272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFP0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13565">
        <property type="entry name" value="HTH_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7157272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="121" mass="13563" checksum="8E917C456FBA31BD" modified="2022-05-25" version="1" fragment="single">MPPKRPAAPSGSTPKRARRVLTLNEKNEVLKQLGSGMSYAAVGRHFGLNESSVRVRQVQKWIKKFRDGGGEDIPTPKPRSGRPRKIQNRTSKVIKRQLDKNPTLTARKLKENNPALLQDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFY6</accession>
    <name>A0A8J5JFY6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin-3-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ank3-L2</name>
        <name evidence="2" type="ORF">Hamer_G009446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFY6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="326"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="417"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="483"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="659" mass="72617" checksum="E87DF3491158215D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JI04</accession>
    <name>A0A8J5JI04_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Foot protein 1 variant 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Fp1-1-L2</name>
        <name evidence="2" type="ORF">Hamer_G027941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035974">
        <property type="protein sequence ID" value="KAG7157950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JI04"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="918" mass="100494" checksum="4379A92F83E69103" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIY7</accession>
    <name>A0A8J5JIY7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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    </organism>
    <reference evidence="2" key="1">
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                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033465">
        <property type="protein sequence ID" value="KAG7159317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIY7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="69" mass="6872" checksum="9DC23082D6F3B5A9" modified="2022-05-25" version="1">MGLLTTAVPTAALGLLTVAMGLLTTAVPTAALGLLTVAMELFTTVVLTAALGLLTVAMRLHTTAVPTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ44</accession>
    <name>A0A8J5JJ44_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nidogen-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Astacidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
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                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7155248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="82" mass="9387" checksum="B16C8D5527D8490D" modified="2022-05-25" version="1">MALCGGDIQRLASHPHTSFKQPHTSFKQPHTSFKQPHTSFKQPHTSFKQPHTSFKQPHTSFKEPHTSFKEPHTKKVVASDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJR5</accession>
    <name>A0A8J5JJR5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G022426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7159812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6371379at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035213420" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="35"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="153" mass="16945" checksum="A8E6B8FC605D09F6" modified="2022-05-25" version="1">MSGNMAWLVMVVVFSVCCCREAKAIPASGLLKLTPSKDLPRIQDGNLPVPLLTCSFVSCDALNIPLNSSISQWDYYIGWDMPQAAKDDPGVFVIGNKFQMPQSHLVLTNFTSNLTGKYTCQLFFRKTFIDDVTINLSLSSTEATRKCNNHTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKG9</accession>
    <name>A0A8J5JKG9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 70-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Tmem70-L1</name>
        <name evidence="3" type="ORF">Hamer_G021419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033983">
        <property type="protein sequence ID" value="KAG7159061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKG9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009724">
        <property type="entry name" value="TMEM70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045325">
        <property type="entry name" value="TMEM70/TMEM186/TMEM223"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06979">
        <property type="entry name" value="TMEM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="240" mass="27289" checksum="65B81AA2947BB4AE" modified="2022-05-25" version="1">MAGVYGVLRNLQHLQRGSYVALLKVPSVLSCTTKVHLCSRITEKQIHICRKSQSLLLTRKFSSQEKQTPSSNTESQVDIGPGSWKEIYHGILSTQIKMVKLFSLSTSFLGLMVQPVLLQKVVGTQMGVILAVGSFIGFFTFVTPLIIHWITKKYVTSLEYDPKRDIYSATTLSFFLRQKKDHQLDDGRSTRSPIFTTFYAKIKPLFVDPPCLKMSCHYGRLMDMINQLTFILWTTEERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLP5</accession>
    <name>A0A8J5JLP5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphonoacetaldehyde hydrolase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phnX-L</name>
        <name evidence="7" type="ORF">Hamer_G022208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032117">
        <property type="protein sequence ID" value="KAG7159826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLP5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050194">
        <property type="term" value="F:phosphonoacetaldehyde hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019700">
        <property type="term" value="P:organic phosphonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000006">
        <property type="entry name" value="Phosphonoacetaldehyde hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01375">
        <property type="entry name" value="PhnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050155">
        <property type="entry name" value="HAD-like_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006323">
        <property type="entry name" value="Phosphonoacetald_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01422">
        <property type="entry name" value="phosphonatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434:SF19">
        <property type="entry name" value="PHOSPHONOACETALDEHYDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7159826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="323" mass="36032" checksum="4FDA69F4391C1BA4" modified="2022-05-25" version="1">MTAPRKRDSENKKRVKLEKAVALSCHCSTASVDHLGEMMEKNDKGNEMLVNPRSEYRVTRRYHGKIKAAIFDWAGTVIDCGVFSAAETFIELFIEEGVNVTNEEARGPMGMHKRAHICKMLEVERVRARWLKAKDGPPTSADVDRMYAKFVPKNIAALQKHSMLIDDKLRGMGIKIGSCTGYPSTIVEKLKPFAAKQGYVPDAIVAADEVPQARPMPYMVWLNAIRMDVSPIEAIVKVDDTVDGIKEGLTAGCWTIAVAKTGNYMAASQHELNIMPHEELERKLTRSYEILHDAGSHYVVDSIKDVPAVVRDINRRLAAGERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNJ8</accession>
    <name>A0A8J5JNJ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034303">
        <property type="protein sequence ID" value="KAG7158845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNJ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="207" mass="23197" checksum="C4EB0F2EBBD820C2" modified="2022-05-25" version="1">MWIITASTSLDPLSNLQTETSIIQITIEEMNIECGEGVLYHDGYQTLFLVIHVGMGKPHRRALCTTMRFYIVQRKSHNHACVNNKPVCLAISGSSCDIPVCPNKCSEAEGRGKCDSSYGLHLYAWICGEDCSIVQRDHQVVVTQLFAPDKIASSLSHLTTVLPRMGHSSLWITADHCGYLVAIRCPWSAYDIQQFDTHNNSVWQQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPJ2</accession>
    <name>A0A8J5JPJ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neuroblastoma-amplified sequence-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nbas-L2</name>
        <name evidence="3" type="ORF">Hamer_G014193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPJ2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054751">
        <property type="entry name" value="NBAS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22913">
        <property type="entry name" value="NBAS_11th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NBAS subunit of NRZ tethering complex C-terminal" evidence="2">
        <location>
            <begin position="612"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1037" mass="115350" checksum="67521BED2C085071" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQH3</accession>
    <name>A0A8J5JQH3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein 254-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Znf254-L1</name>
        <name evidence="11" type="ORF">Hamer_G022330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028009">
        <property type="protein sequence ID" value="KAG7162241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQH3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="163"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="333"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="484"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="546"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7162241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="612" mass="69593" checksum="C06F8B5C68BD4267" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSD1</accession>
    <name>A0A8J5JSD1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSD1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="146" mass="16966" checksum="8522089E2CD07FFC" modified="2022-05-25" version="1">MRCLCAAWRPLWPECVLQRNFEGFKELEEEAVVHEIVSLGNSMGLEVDDNDVEELVEEHSKELSTEELHELHKEENETLKRSLTSEESGEDEDKEESRIIPAKDLKDAFFCWSKLSKLAEDYHPDVGSVEKAISVFNDTVMNYFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSZ7</accession>
    <name>A0A8J5JSZ7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sodium-dependent phosphate transport protein 2B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSZ7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="111" mass="12399" checksum="BC34FF2AA70BF9EF" modified="2022-05-25" version="1" fragment="single">RRSRALCDRVLVECTCTCPSRGLKLLQSLGMVKKAGSKLVKKSKKHGIPRDELVTVKSDLILLAPEFEDIEEKRLEGSTWSRPNQRDPEDPHKGQLRRWACLCGDGSSPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JT20</accession>
    <name>A0A8J5JT20_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Low-density lipoprotein receptor-related protein 4-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Lrp4-L2</name>
        <name evidence="8" type="ORF">Hamer_G019936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028706">
        <property type="protein sequence ID" value="KAG7161921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JT20"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000008">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF41">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="5">
        <location>
            <begin position="100"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="5">
        <location>
            <begin position="143"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="5">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7161921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="493" mass="55291" checksum="46C0E84FD1251E9C" modified="2022-05-25" version="1">MKDNRQCNEEPNNYLIFAAKGMLGRISLDTKPLWDVPLGVSATSRPIDVDFHRKKDLLFYTDADQDLIRVVSLKNLSMPWALTTSNYVTPDGLAVDWLADNIYWTDAGRKAVEVARLDGTCQKVIIKTLLMEPRAIAVFPSEGLLFWTDWGNMSKIERSYLDGTERKVLLDVDIGWPNGLTIDYKMRRIFWNDAKGDTIGSSDLDGENRVMLVQQVPHPFGLTLLGNHIYWTDWQTLTIERADKTTGNNRKVIRSGIAGIMEIKAVTRASQRGWNQCADRNGGCSHLCLYHPTGRRCACPDTHDSRICSERKYWSHLASVQCSKLMKPMPLALPPEPRRRPDSEMERNGSRGADEAPGLIPLLAVLALVLLVSVLAMMAVVGWWNASNSDVNTDRKPFTWRRLHHDANHQDSSRAATEEEGEAKLGRMFEEKGEVAALISEQQRGAGPQPRPHRQIPLSNYAHTAHTPSPGLVPDLHQTSHTAAHHAQTCPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTH4</accession>
    <name>A0A8J5JTH4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CENPB DNA-binding domain containing protein 1-like 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G010824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTH4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="110" mass="12259" checksum="2B7360F608C2E2E6" modified="2022-05-25" version="1">MPPNHPLSYGTSGAKKCKAITVEIQMDVLKHYEGDERTAHTICDLEVGQSILRTICDGAEKIKESAKSGTLISASKTSYSRSMIMERMEQMLSTWIKHHTVSVSMFVIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVI5</accession>
    <name>A0A8J5JVI5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">7-dehydrocholesterol reductase</fullName>
            <ecNumber evidence="18">1.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Sterol Delta(7)-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">DWF5-L</name>
        <name evidence="24" type="ORF">Hamer_G002036</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>7-dehydrodesmosterol + NADPH + H(+) = desmosterol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17737"/>
            <dbReference type="ChEBI" id="CHEBI:27910"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:46741"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>cholesterol + NADP(+) = 7-dehydrocholesterol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23984"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:23986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Steroid biosynthesis; cholesterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.21" evidence="18"/>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7162993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVI5"/>
    <dbReference type="UniPathway" id="UPA00063"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047598">
        <property type="term" value="F:7-dehydrocholesterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016132">
        <property type="term" value="P:brassinosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF38">
        <property type="entry name" value="7-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="5" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAG7162993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="250" mass="29128" checksum="5FE59105390F91EE" modified="2022-05-25" version="1">MELHPRMLGVDVKQLTNCRFGLLAWELLVVAFFLAGWERNGFSLAHLVCATLQTIYLAKFYWWETGYFNTLDIILDRAGYYICWGCLVFVPSLYTYASFFLVAHPPLVSTTAAIFFFILGLCAIIGNYRIDWEKEYFRAMDGKCDLWGRPATYIEAEYTSASGPKRSKLLTSGCWGVARHLNYTFELLLALSWCLPGLGYGFWPFLYVIFLTVLLVHRVFRDEDKCRDKYGASWDKYCREVPYRMIPWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVK0</accession>
    <name>A0A8J5JVK0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glycine receptor subunit alpha-4-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Glra4-L4</name>
        <name evidence="16" type="ORF">Hamer_G008005</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13 14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVK0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="709"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="15">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7162460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="730" mass="84032" checksum="11F381DF7EBB099C" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWC6</accession>
    <name>A0A8J5JWC6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SCAN domain-containing protein 3-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ZBED9-L9</name>
        <name evidence="1" type="ORF">Hamer_G007915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWC6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF22">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="531" mass="60552" checksum="B0157FA322007EA4" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWD2</accession>
    <name>A0A8J5JWD2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichyl-phosphate beta-glucosyltransferase-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ALG5-L1</name>
        <name evidence="2" type="ORF">Hamer_G007310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWD2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="111" mass="12478" checksum="2EA4CA53EBC36027" modified="2022-05-25" version="1">MKIVYCVTMDFIILLTYLIGLAVVALLIAQVFCVIDSLNLSFIVPVMMEECMGYLEERAEQDSSFTYEVIIVDDGSKDKTTEVGMGYNKKYGCDKGILTLAKNKRVALSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWG9</accession>
    <name>A0A8J5JWG9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative CD80-like C2-set immunoglobulin domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G023953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024170">
        <property type="protein sequence ID" value="KAG7165540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWG9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF15">
        <property type="entry name" value="BEATEN PATH IIIA, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7165540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="152" mass="16843" checksum="3A40E2D29C4F1A7C" modified="2022-05-25" version="1" fragment="single">LPESAPVLEGASSSYQLGERVVVNCTSLYSKPAATLQWYINNQLVTEVGSLRKYPPQKERDGLETAVLGLTFITSRSHFPRGEMRLKCVAKIATVYFQSQETSVIETGFLPQTQAEERRHNDHFYFLGSSSTAASAGWSLLILVALVILFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYH5</accession>
    <name>A0A8J5JYH5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Echinoderm microtubule-associated protein-like 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Eml1-L</name>
        <name evidence="6" type="ORF">Hamer_G011034</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYH5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002220">
        <property type="entry name" value="EMAP-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005108">
        <property type="entry name" value="HELP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF50">
        <property type="entry name" value="ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03451">
        <property type="entry name" value="HELP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7166212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="197" mass="22388" checksum="7E9E8C4CDC588A0A" modified="2022-05-25" version="1">MSVYELKSVCVFCKDLSHGNIILIFLRAREAQYNPDEGVVKLYLRGRPLNLYVPTALQETYSPTASTSHPPAKLKLEWVYGYRGRDCRNNVYQLPTGEIVYFVAAVVVLYNVEDQMQRHYLGHTDDIKSLAVHPNKLLIATGQTAGHDRRDARSWRLNPPADHLSPEAEEWVRTSQSPSPPDPDLASWSKVMFCTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYL9</accession>
    <name>A0A8J5JYL9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 12 member 6-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Slc12A6-L1</name>
        <name evidence="7" type="ORF">Hamer_G010501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYL9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF73">
        <property type="entry name" value="KAZACHOC, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7166830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="158" mass="17516" checksum="3BB5A0B57F68955B" modified="2022-05-25" version="1">MVGKLASLFSFSKLEEEGDNGHNTPNKGSKRIPDLTHSIYGADDKPFMVDMKEMSGYEKNLYLYSEEMADRPRVSMMINSLANYNATIPSAEENDSKPTKPVAKLGTLMGVFLPCIQNIFGVILFIRMPWIVGTAGGAFAFTIVLMCCCTVSKYCLMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZE1</accession>
    <name>A0A8J5JZE1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lysosomal-associated transmembrane protein 4A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LAPTM4A-L</name>
        <name evidence="8" type="ORF">Hamer_G003683</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LAPTM4/LAPTM5 transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZE1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004687">
        <property type="entry name" value="LAPTM4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051115">
        <property type="entry name" value="LAPTM_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479:SF10">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03821">
        <property type="entry name" value="Mtp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7164474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="496" mass="53909" checksum="B3B5C1DAF5AB7F83" modified="2022-05-25" version="1" fragment="single">EAMFAASYRRALRRARIRRILMNQEGVEVRDIRPPDYTEQPTPPPTYVKMSEVALGSDTVVVSGISGTQTGRTESSREGVSIGCEAQEGGGGGEAPAVAAAEGSTMLGRGRLQEAQGRLEAMRKRHNQWTCFLCCHVRTGTIVIGFWHMLLHLMALSLIAVVVVHPEMLSQTGGTLGGLGSGDELSVNPQDVQAENCAEMPCSLAARGDGSSNQAASDFSLFLGNLLTTHRLTTDDVNIALFITLCTFVVTLLLVYGAFHSQPSHLMPFFFLQVFDFCISSMTMIGYLSYLPNIRQLIRESPEFPFQEQLLAMNTKCLTFFAMLIFITTLMTKAYCISIVWRCYKFLMLRAQAGRSVLRYLDGVSGPVDQESQTLVMGQDLPDYDNAMADPQYSYRKKLPGIFPEPPPSYDMAMAALFARQEQGQDHVDTAGGACEGSTVSSPSHDQAVVTTAQEHPVPITSSTSAATSVPTIPHTAIFPTTTNAASLTIGSPTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZU2</accession>
    <name>A0A8J5JZU2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Velvet complex subunit B-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">velB-L2</name>
        <name evidence="2" type="ORF">Hamer_G012988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZU2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="546" mass="56967" checksum="98A8436AC320EC31" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0H5</accession>
    <name>A0A8J5K0H5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fanconi Anaemia group E protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G010241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0H5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039685">
        <property type="entry name" value="FANCE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32094">
        <property type="entry name" value="FANCONI ANEMIA GROUP E PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32094:SF5">
        <property type="entry name" value="FANCONI ANEMIA GROUP E PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25248" checksum="2BEAAACCA9697414" modified="2022-05-25" version="1">MKFSRMCSDLSCDDTIEPLDACSSNALIINDEHLVQICKKSEKSGEPAAALLGRLLILPKLYHLPSKLSTPAVEALLEFLQWHTAVMVTHVLVPVLQYCPETGEQHRDVVAHLVSECSYGYVTQMLSAIAMRVSIRDDDVQIFQLLCDHADQQSTATHKAALAFLKKTADKYKTYVKFGQCLLFVVKKMGQYIEDHESLQLIVNNHSSSLKKAIEVQMKKAKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1T6</accession>
    <name>A0A8J5K1T6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Carboxypeptidase M-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Cpm-L</name>
        <name evidence="12" type="ORF">Hamer_G004698</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7164968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1T6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000020">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1120:FF:000015">
        <property type="entry name" value="carboxypeptidase D isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF84">
        <property type="entry name" value="CARBOXYPEPTIDASE M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7164968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="353" mass="39729" checksum="DB4A6FDA8AD99F18" modified="2022-05-25" version="1">MVVSASPYEHIVGQPNVKYVANMHGNEAIGREMLLHLIEYLAKSYGTDDYVRWLLDNTRIHIMPSMNPDGFEVAREGTCQGGQGRYNSRGFDLNRNFPDYFKQNNKRNQPETEAVKQWVSKIQFVLSANLHGGALVASYPFDNSPNTIFQQFASTPSLTPDEDVFKHISSVYSFNHASMHLGLPCKPGAPTFTNGTTNGAAWYPLTGGMQDYNYVWHGCMDITIEMSCCKYPTAEQLPKFWEDNKKVHRGVRGFVKDEQDRPVEAASIKIKGRDVGFQTTKYGEYWRVLLPGHYTIEVYAQGFDPREEEFTVVESNPTLLNLTLYRAAPAPDALPSRPQQQQPETAAGVGHCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2M5</accession>
    <name>A0A8J5K2M5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2M5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="68" mass="7897" checksum="6B8E51FEEDA48927" modified="2022-05-25" version="1">MSYNQFNDSQGRTAKYFVTERSELLRCHVSNHTSLPVKVNPYSKQNTVNVTPGPEDRLEKMRRKLSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3C9</accession>
    <name>A0A8J5K3C9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zwei Ig domain protein zig-8-like 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">zig-8-L19</name>
        <name evidence="4" type="ORF">Hamer_G022381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023413">
        <property type="protein sequence ID" value="KAG7165823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3C9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF41">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035323574" evidence="2">
        <location>
            <begin position="23"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="52"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="156"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7165823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="322" mass="34286" checksum="A42A7BDE54926AFB" modified="2022-05-25" version="1" fragment="single">MWAVWTCVVWTCLILLVQPSFGYRSGGGVRPGTEDLPAHKRQSVQYSTLVGPSFINATLNAHAHAPIGQTAYLTCMVRNLHNYTVSWVRARDIHLLTAGETTYTSDHRFVAVNPAGGAQWVLRLHHAQPTDAGTYLCQVSVTPPISTSVTLLVTEAAATVYPGREVFLKESSRLVLVCEVRGCPYPAHPTWYRGRQVQDGTEVEEGHVTASPPTPPTESSSSSSSSSSSSTTTISLTTDPTTVASTITIITSTSLLSTSTTTIPSTTTTTTTTTTTTTTPAPIGLPIAKATLTRPRAKVAHSGVYTCTNSCTSPVNVTLHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3H4</accession>
    <name>A0A8J5K3H4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein 94-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Tmem94-L4</name>
        <name evidence="2" type="ORF">Hamer_G027831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017841">
        <property type="protein sequence ID" value="KAG7169230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3H4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="202" mass="22800" checksum="B1CC39D7685629AE" modified="2022-05-25" version="1" fragment="single">EMACSADGLPTSEALSLLHEDISIALDEYQKTEAEKNKGFGPKSVLYEAFHHKSSLSVFHWTSVIALIVEGIVLLVAFAACNDPRYQHLPAESFFIFLAVILNVYLVWWDTQLRHKEVPRLTHNVLKDLKEYHGNVLWSAENYPHLHSPCITLQWTRRDGNTVNLPWSLLGSVLGPLLFTVHTSSFVILLDVHGVALLFPCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3I7</accession>
    <name>A0A8J5K3I7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein heavy chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G010539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3I7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="240" mass="28171" checksum="33BB05423EAB6A60" modified="2022-05-25" version="1">MGSVSGSENVVQDIKECQHRTTWSVSIISGDENVGITRKSSAVQEKCQQSGKKKKKKKKEKEEEGEGGGGGGGGGGGGGEEEGRRRRRRRRRWEEEEKKEEEEEEEEGRKFISTNKNVSTVSAVRRWNVRHVFIQVRHVFIQVRHVFNQVRHVFNQVKHVFNQVRYVFNQVRHVFNQVKHVFIQVRHVFIQVRHVFNQVKNVFNQVRHVFIQVRHVFNQVRHVFNQANLVFTLHPPYTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3U3</accession>
    <name>A0A8J5K3U3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026894</name>
        <name evidence="3" type="ORF">Hamer_G028794</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022673">
        <property type="protein sequence ID" value="KAG7166108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010009675">
        <property type="protein sequence ID" value="KAG7173495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3U3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7173495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="81" mass="9087" checksum="9B053C2C6993E7D0" modified="2022-05-25" version="1" fragment="single">ARAVVLECREEAGRRKRLIAEERAALTTRTTAAEAAHRRLRAQLERYETLAVQLVNDLRLNQPGSARRTSTNTTTSNTHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3W3</accession>
    <name>A0A8J5K3W3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bile salt-activated lipase-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Cel-L9</name>
        <name evidence="1" type="ORF">Hamer_G020586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017093">
        <property type="protein sequence ID" value="KAG7169365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3W3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="138" mass="13169" checksum="89B11313FE67798C" modified="2022-05-25" version="1">MCGGAGGSIVKMSGDEGGSIVKMCGKGGCIVKMCGDEGGSIVKMCGDEGGSIVKMSGGKGGSIVKMCGGAGGSSVKMCDDEGGSIVKMCGDEGGSIVKMSCGKEGSIVKMCGGEGGTIVKMSGDEGGSIVKMCGKGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3Z1</accession>
    <name>A0A8J5K3Z1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat-containing protein 13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Wdr13-L</name>
        <name evidence="5" type="ORF">Hamer_G011004</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3Z1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="198"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="434"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="475"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7166183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="567" mass="62387" checksum="E0D5AE8709EC4514" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4C7</accession>
    <name>A0A8J5K4C7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stu1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">stu1-L2</name>
        <name evidence="2" type="ORF">Hamer_G021345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017879">
        <property type="protein sequence ID" value="KAG7169216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4C7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="218" mass="24264" checksum="25938D84AAF8100C" modified="2022-05-25" version="1" fragment="single">HPETVVDWNCLVEDRVKCRVEGWVESWVEGRVDGLVQDRVEGWVEVRVEDRVEGRVEDSVEDRVESWVECRVDGRVQDRVGGRVEVRVEVRVEDRVECRVESWVESWVECQVDGRVQDRVGVGWRGSCGGPCGMGWSVGWKLGGVSAGVSLVLALLLALSAVLTSVNADPVADPEPFFLKFLKLKKGKKGGHRGPPVHVVYRPPPPPKGYGHQSGYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K630</accession>
    <name>A0A8J5K630_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K630"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035209202" evidence="1">
        <location>
            <begin position="27"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="226" mass="25245" checksum="4E5B4AEAD58770E0" modified="2022-05-25" version="1">MMAGRVMLMVMVVIVVMSWMVFPVRAEHPSVLLVESTVFGNMILAPGKMISEDNDIYDTVNVTPPSICSCRTACWSSRRCVSAVVLETEDGANNTSVMYEMLEDNLLYLVLPQASSLIAAKSDCEKIPGHRLALLKTDNHFQAVKKRMSGLDMTLRIDLLKFQNGDEVWGDGTPFSLSQIIETGETSMVSLYFVPVILNSNLNFQIYNFQDALYPLCQANPFGQDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K665</accession>
    <name>A0A8J5K665_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polynucleotide kinase 3 phosphatase-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020160">
        <property type="protein sequence ID" value="KAG7168284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K665"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="192" mass="21398" checksum="03127598D92123E5" modified="2022-05-25" version="1">MALELLADYTPYTVIVRQLGPNILLGEYHHRIEFDPPPDTASSKSTCHTTDIEMPRRKTVAARLKATDNPDKGEGGWETYADGDLLVFKKNMAGRSKIAGYDMDGTLIVTKSGNVFAKDYNDWKIIYSEVPGKLKKLHQDGYKIIIFTNQAGIAAGKHSVAGVQRKISSIIERLYQSRHLYQQGKESTGNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7T4</accession>
    <name>A0A8J5K7T4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase RBBP6-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Rbbp6-L1</name>
        <name evidence="7" type="ORF">Hamer_G011733</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7169034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1" key="1">
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
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                <person name="Greenwood S.J."/>
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    </reference>
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    </comment>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5KD01_HOMAM</name>
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        <submittedName>
            <fullName evidence="3">Putative ML domain-containing protein 1</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016259">
        <property type="protein sequence ID" value="KAG7169498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6339677at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035200544" evidence="1">
        <location>
            <begin position="24"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="2">
        <location>
            <begin position="32"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7169498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="172" mass="19488" checksum="7CEA98735BDB6335" modified="2022-05-25" version="1">MRMWCCRMTRVLMLVTSFYLAQGIRVDDKEGFTLCNVPQLAQLNSVEVRECTKWPCLARAGRSGTYQITLTQQTNEDLYNIKSDIYAWVRLPFINANNKPVRVSMPGEKKKPLCRFTDTGCPLAPGVPTTIRKSITIPIQARMAQGNVVVEFRVTDDNERVLTCFRAPVIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KDA2</accession>
    <name>A0A8J5KDA2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative panusin-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">panusin-L1</name>
        <name evidence="3" type="ORF">Hamer_G026162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014306">
        <property type="protein sequence ID" value="KAG7170403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KDA2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035232254" evidence="2">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="87" mass="10089" checksum="FD0ED3064CE3F446" modified="2022-05-25" version="1">MNTKTILFLLVLVIVAATVVNAGNFGETFAYEGRIFRLTFVIAMLKYLSGDEKEQGKEERERRWRNKKRIKGRGHGGTREGRRKENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KDF1</accession>
    <name>A0A8J5KDF1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G023360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021101">
        <property type="protein sequence ID" value="KAG7167904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KDF1"/>
    <dbReference type="OrthoDB" id="10043580at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040219">
        <property type="entry name" value="KIAA1143-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31195">
        <property type="entry name" value="GEO02494P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31195:SF2">
        <property type="entry name" value="GEO02494P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="10"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7167904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="167" mass="19264" checksum="5BAB763D7E20AB68" modified="2022-05-25" version="1">MAGWTGKRVNVSYSRPEEPAFLKRFKEQVGYKEDNGLQEKFAVMPAATDEDLEDQDDDMPQVVSLRSNDLTQEECDKLRAEGKLDDLLRGNCEKVNVSKEEDEEPPPDGRILFRKPTKRSGEDKDGKTDPKKLKGDEKEKKSKKDKKKDLQKKKLLSFNEDEEEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KEF9</accession>
    <name>A0A8J5KEF9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine-dependent NAD(+) synthetase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Nadsyn-L2</name>
        <name evidence="10" type="ORF">Hamer_G024151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013511">
        <property type="protein sequence ID" value="KAG7170786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KEF9"/>
    <dbReference type="UniPathway" id="UPA00253"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="599"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="677"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7170786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="745" mass="83542" checksum="00465AD1D52EDF1E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KK92</accession>
    <name>A0A8J5KK92_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G030126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012685">
        <property type="protein sequence ID" value="KAG7171220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KK92"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="65" mass="7398" checksum="7EEF2750B526CF02" modified="2022-05-25" version="1" fragment="single">NSYDKLSKMTQRPLPQFDAYKNRQRIVVNNGPVNFGWLKSFLGSSCESQVHRGLGQHNIPPRNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJH6</accession>
    <name>A0A8J5MJH6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ionotropic receptor 40a-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Ir40a-L4</name>
        <name evidence="11" type="ORF">Hamer_G009396</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJH6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="59"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7153726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="208" mass="23382" checksum="281EA9FF689C27D4" modified="2022-05-25" version="1" fragment="single">VIGSVERVEADFSLNIAITQDREEKVDCTIGYHVEPITFATSKPRLLNQALALLRPFTPEVWAAFVATLVMVGPFYYLVCRWSCYHLTPSPPSAIKASLLVFGACFNQSVKWVSGLCPRMFIMTYVLTMFVAVTMYVAMLTATLTLPALSPTLNSLEELVQSDFSWGIQLVYQGLEPCPSLDECINQARDTKYAFITWRTYLEDRIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK34</accession>
    <name>A0A8J5MK34_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Acetylcholine receptor subunit beta-like 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Achb1-L</name>
        <name evidence="21" type="ORF">Hamer_G023279</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045124">
        <property type="protein sequence ID" value="KAG7154132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MK34"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000035">
        <property type="entry name" value="Acetylcholine receptor subunit beta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000038">
        <property type="entry name" value="Acetylcholine receptor subunit beta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12 21" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="2"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="163"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG7154132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="430" mass="49923" checksum="8B22F6CF92776096" modified="2022-05-25" version="1">MNEVWKDYQLRWDAADYGGIKVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPHGEVLWVPPAIYQSSCTIDVTYFPFDQQTCLMKFGSWTFNGDQVSLSLYNAKNFVDLSDYWKSGTWDIVEVPAFLNVINNTPHPTETDITFYITIRRKTLFYTVNLILPTVLISFLCILVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFVMNTVSILVTVVIINWNFRGPRTHRMPNWIRVMFLKYLPIMLFMKRPKKTRLHWMNEMTDTIKCEHPSVTAGVPPHHHYGSPEVDKGTSKIEQMELSNLHHPNCKINREMPRRESESSDSLFITPEAYKATEAVEFIAEHLRNEDEYIQIREDWKYVAMVIDRLQLYIFFAVTTAGTIGILMDAPHIFEYVDQDKIIDTYRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLC1</accession>
    <name>A0A8J5MLC1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative PDGF/VEGF domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G022612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041542">
        <property type="protein sequence ID" value="KAG7155465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLC1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000072">
        <property type="entry name" value="PDGF/VEGF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00341">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50278">
        <property type="entry name" value="PDGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035253898" evidence="1">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Platelet-derived growth factor (PDGF) family profile" evidence="2">
        <location>
            <begin position="52"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7155465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="136" mass="15266" checksum="FF21B504E1A23F73" modified="2022-05-25" version="1">MMMQTCICMVVGVVLLTLGSAVSLPANNHIIENQVKELQDMGCKPVMQKVLVVDLLDETDDLIEMLYFYPQAVAVRRCVEDCSFCGNNHGKIKGRCVASSREEKTFVVTYYENTSPPTKHQRTMTTVEHTQCGCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLV7</accession>
    <name>A0A8J5MLV7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G-protein coupled receptor GRL101-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Grl101-L6</name>
        <name evidence="12" type="ORF">Hamer_G020200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040230">
        <property type="protein sequence ID" value="KAG7156035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLV7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035153893" evidence="10">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7156035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="300" mass="32852" checksum="0EF1547C53F073BB" modified="2022-05-25" version="1">MAAVWVLVGFLSALPLTHLEYFNNFYGRSGVCLALHITNEKPNGWEYAVFIFLVLNLLSFGVIAVSYVFMYVAARDTHTAARTSTETRGSDGGMAKRMTMIVATDAACWLPIIFLGIASLCGITIPPKVFSWIAVFVLPLNAAINPVLFTLSTAPVRKRLNYLRQGVTSKHKRSASAVSGSRLASSYKTRMATDVTDIAQQGDNDLRILNVTHKSPLGDRKVAINGSEDSLPPTLNGDESIQAPQYPQKSLSSEVFQEETDSGALELVPLKELTTTTPGTKKALSRKHNRKKNPSDNRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MM41</accession>
    <name>A0A8J5MM41_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MICOS complex subunit MIC13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">QIL1-L</name>
        <name evidence="10" type="ORF">Hamer_G020552</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MICOS complex subunit Mic13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039068">
        <property type="protein sequence ID" value="KAG7156471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MM41"/>
    <dbReference type="OrthoDB" id="5948578at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026769">
        <property type="entry name" value="Mic13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31816">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31816:SF3">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15884">
        <property type="entry name" value="QIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="127"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7156471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="186" mass="20871" checksum="810EFF6771DF45E0" modified="2022-05-25" version="1">MVKQKRREPSGVTISRRRGVNYTMNKVLKVAWFATKVGIGGGVIYVTVDQGIWGDSHRAAATYDRLYDIMPGTKSVSEKYLQLPKKDDVNINFRSYWNTGIFYTFDFIANLPSKIVRLKDVIIDFATSPPVPDKQNEQQLKAEETNMEESQLPPSTPVDDVTATPPQDSVDSPPPLVPHQADEKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMB2</accession>
    <name>A0A8J5MMB2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Actin-like 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Act-L23</name>
        <name evidence="12" type="ORF">Hamer_G006689</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMB2"/>
    <dbReference type="OrthoDB" id="6331703at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0558">Oxidation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7156696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="376" mass="41743" checksum="2DFE3F4E84022676" modified="2022-05-25" version="1">MCDDDANALVVDNGSGMVKAGFAGDDAPRTVFPSIVGRPRHQGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEESPVLLTEAPLNPKANREKMTQIMFETFSTPAMYVAIQAVLSLYASGRTTGIVTDSGDGVTHTVPIYEGYCLPHAILRVDLAGRDLTAYLMKIMTERGYSFTTTAEREIVRDIKEKLCYVALDFENEMSVAAASTSLEKSYELPDGQVITIGNERFRCPESLYQPSFLGMESVGLHETVYNSIMRCDIDIRKDLFANNVMSGGTTMYPGIADRMQKEITALAPSTIKIKIIAPPERKYSVWIGGSILASLSTFQAMWITKEEYDESGPGIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQL8</accession>
    <name>A0A8J5MQL8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein 121-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Znf121-L</name>
        <name evidence="11" type="ORF">Hamer_G012686</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQL8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF70">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="337"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="385"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7160145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="705" mass="79280" checksum="7E2C66A9522BDD89" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRL0</accession>
    <name>A0A8J5MRL0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G013993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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            <end position="152"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    </evidence>
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            <dbReference type="EMBL" id="KAG7161360.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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</entry>
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        <name evidence="3" type="ORF">Hamer_G016230</name>
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    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </feature>
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    <feature type="region of interest" description="Disordered" evidence="2">
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    <evidence type="ECO:0000313" key="4">
        <source>
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            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
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                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
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                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
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    </evidence>
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                <person name="Romanova D.Y."/>
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                <person name="Greenwood S.J."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="446" mass="48326" checksum="6B332D2906DE45A6" modified="2022-05-25" version="1">MICNSGLLITRKLKELVTGGDFSPSKRCPPSKAVTLKPISAEPVHVCHNGVIPGHDPRPGHPPGEGQCRGVEILDAWDATSEPFESPSIVCGSLGESPLYGESRFSSLSRPGKTQPEFTKINGKTVRLYSSLPRASLTRGKTPTFSAAVTQEAHTAPRHPPPPPSPAPAKLSLATNHHHHQQQQQAGVHYVALSDIYAELPRKKKKPCVVQTCTSVHHRHDPSSSSSSTYTSTHSSTYTTTSSNSTLPSNNDDDKKFNSLEFSRKKHDKSKFLQKFNSLDRGWKSFMSPRTSGNKHGLASLSRRPDGQVTHASSLKGRPQLEVSKDNNSSRSRGAAKTSSSFSSSSFLSSSSPSHPHQRHTLTPSGHTKDRHHHGKLRLPPAPEAYVHQHPGGQSRGGCPPAGKCKARDEGNTKHDVISATQKGERQQETSGGEEDHNDASYHTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTQ4</accession>
    <name>A0A8J5MTQ4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027102">
        <property type="protein sequence ID" value="KAG7162784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTQ4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="286" mass="31120" checksum="CA51E575E8C874B3" modified="2022-05-25" version="1">MEPVPSTSAASTDQSHQPLQHLQNQSHQPLQHPQTSPINLSSIYRTSPINLGSIYRTSPINLCSIHRPVPSTSQHLQNQSHQPPAASTEPVPSTRRPQNQSHQPPASTGINLGSIYRPVPSTLQHLQTSPINPGIYRTSPIVPSTSAASTDQSIITSPSAASTEPVPSTSQHLQNQSHQPRQHLQNQSYQPLQHPQNQSHQPRQHLQTSPINLGSIYRTSPINLGSIYRTSPINLGSIYRTSPINLCSICRSSPINLCSIHRTTPEADNSPEPTLLTSSSSSVSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU00</accession>
    <name>A0A8J5MU00_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7162979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU00"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035316547" evidence="1">
        <location>
            <begin position="20"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="534" mass="58940" checksum="73A290DCFB733924" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU29</accession>
    <name>A0A8J5MU29_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PiggyBac transposable element-derived protein 4 C-terminal zinc-ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU29"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12434" checksum="EAE9C69D86222AC2" modified="2022-05-25" version="1">MSRTGGKLLKRRTYMQALARYLITPWAEKRLRSSCLSWGLKALICSVCDLPSPGSVSRPPGTPVADSKDPLVRCVECPKGCDRKTRHRCHGCRQPMCPRHFYSVCANCVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUR0</accession>
    <name>A0A8J5MUR0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trypsin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Tryp2-L</name>
        <name evidence="7" type="ORF">Hamer_G004924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUR0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7165140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="276" mass="30086" checksum="4FCC3D1656F66A40" modified="2022-05-25" version="1">MWMDIGGSTLLMKCSYALDRRRRSRDYLQVTADDAQAERYYGSGSVEITAETRLDVYFQSNRKNTGIGFECTVSSIPAGGETTPPAQTTAYKCLEATRIVGGQVTDPHEYKFQVVVRTTDNTLCGGSLIHRKWVLTAAHCVSGKNRNQVFVYLGAHQYNDNTNERGAEDLIIHPLYNSNRNDNDAALIKIADAMASDTVGYVCIASNRANLYSQGTATVIGWGTTSSGGSISSTLREADVPLMSNSECSSRYLNYGSYITDNMICAGQPGTDSCQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVL7</accession>
    <name>A0A8J5MVL7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Exonuclease 3'-5' domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">EXD2-L2</name>
        <name evidence="16" type="ORF">Hamer_G005064</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the EXD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVL7"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000041">
        <property type="entry name" value="Exonuclease 3'-5' domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="15">
        <location>
            <begin position="56"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="604"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7164674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="854" mass="96761" checksum="DD027B138611D455" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWV0</accession>
    <name>A0A8J5MWV0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6370754at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1295" mass="151582" checksum="999928D72F51BC7B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXV1</accession>
    <name>A0A8J5MXV1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G012859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXV1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="122" mass="14169" checksum="FA748E0E670E8A2F" modified="2022-05-25" version="1">MKKTALYRYSHEEDWVLLPLPHEETGYCTATPCEEDLGAVPLPHEETGYCTATLEEDWVLYRYPMKKTVYCTPCYPMKKTGTVLPHEEDWVLYRYPMKTTPMKKTVYCTATLKKTDCTTATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXW7</accession>
    <name>A0A8J5MXW7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tectonin beta-propeller repeat-containing protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Pex23-L2</name>
        <name evidence="3" type="ORF">Hamer_G018423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7167993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXW7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006624">
        <property type="entry name" value="Beta-propeller_rpt_TECPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051513">
        <property type="entry name" value="Tectonin_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250">
        <property type="entry name" value="DYSFERLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250:SF1">
        <property type="entry name" value="TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06462">
        <property type="entry name" value="Hyd_WA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19193">
        <property type="entry name" value="Tectonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00706">
        <property type="entry name" value="TECPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxin/Ferlin" evidence="2">
        <location>
            <begin position="87"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7167993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="640" mass="69492" checksum="E7F2AC5B6291CC5B" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY50</accession>
    <name>A0A8J5MY50_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G025810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019241">
        <property type="protein sequence ID" value="KAG7168740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY50"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="91" mass="9810" checksum="5DA4CBDB0E7DFEB9" modified="2022-05-25" version="1">MLENLCLAAERSPDSMFRTSIHGSGIHWMAHSSGSWLGFRELRICGVQISNGVVIKRCTSEEGRAFQDGRGCGAGGRGSQLWLIANCVTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYG9</accession>
    <name>A0A8J5MYG9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYG9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="32"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="137" mass="15557" checksum="98533E30277DCBE6" modified="2022-05-25" version="1">MPEARKLIFCPSMCSEVKQYIESCNICASSASRQAPEPLYLHDVPDRPWKKVGTDIFTIKRRDYLVTVNSFSQFIEADNLPVSDSETFVFKLESHFARHGIPATLISDNGPQFTSKHFQQFTRAWNISHETSSPGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZY3</accession>
    <name>A0A8J5MZY3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G022969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014835">
        <property type="protein sequence ID" value="KAG7170213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZY3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7170213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="178" mass="15579" checksum="D427BF3D7578318C" modified="2022-05-25" version="1" fragment="single">GRAGGPTLALGSRPAIYCSPLPGCFNKLRIAERYPLYLVSAQGAYTIMLIHRALALIALVALVTHGEKRHNLVVHKAIGGLTILGSSGSIGAFNGRSGGKGFGSGFGAGGGGGAGGGAGGGVGGGAGGGVGGGAGGGVGGGAGGGGGFGGGAGGGVGGGAGGGLVVGGGGGGGAGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0S0</accession>
    <name>A0A8J5N0S0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hemicentin-1-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Hmcn1-L4</name>
        <name evidence="4" type="ORF">Hamer_G013854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012946">
        <property type="protein sequence ID" value="KAG7171065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0S0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035307752" evidence="2">
        <location>
            <begin position="19"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="253"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7171065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="465" mass="51773" checksum="4C8D15979D6BF93E" modified="2022-05-25" version="1">MKSIGNLVFLGLVGLCLGQGFGGMQAGGEVLWTEDYTIDNMGSSPIIIASDTGQVNFPFYRELPTSTPAPLGGVGGTDGTETDAKGESWSPHVTYKGKPFVAEREAFSVLCNLTLFDQLKWTHNGKPVVAGEGGYSMTEEPGPEGFITSRLSVANAHMYHAGQYKCTSFIPRSHTVFVLSANSSGTESVQVLFVGYPMRLSCNLTNQDDEKLESGDHIKIFQENSSLLINSPVREDVGIYKCETDSGIPLDKPFFKTIQVIHFEIRRMDKSMNVDMEKDIVLICPVEGKPYPNITWKKDDRPVTELINQTRITYEPNEHDVPNSKIIIASAGWADRGNYTCVIDSLSKTFERFTFIRVKEVLLLGIIIFIFEKRRVKAEFEESDTDQGNDQKNTAEHNKDLVRQRKKTKIHCDTRSEVTVEPLSRAITALVADNDKLREECVRFCLNILSSPCSSYVADTAYACI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1H9</accession>
    <name>A0A8J5N1H9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012106">
        <property type="protein sequence ID" value="KAG7171490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1H9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="470" mass="51666" checksum="8E053AEF451A6BFD" modified="2022-05-25" version="1">MPTTSRPRHHFPDQWPSEHCLGVVTPYGKLSNEAALMIMASSPETANEGGDREAAAGTAASSRSGREEGEEASPSEEHPGGESRPSDDSKDTQSQVYNPESQRVTHLSRQIQRRVKLLSRFPRSRETQAASEAPSLAGLHITGLSVRARHTWRHCPKEDSERRARRYLVEVDEHLSTRHRRKEAPRPPRPAAITRNNQITPARTPVAAQRDHSGKHSQSHTVGRCDTQPRPPHHPRVSSYNSCSGTKVQEKGSAAALCGVLLIQNSRLCVQRVPRHSRSAPPQPQPTPQVPLAITPPPPQTRLPTPDQPLDPFPVHPGTLFTVTVRTTPTHQHLTRPLLQNPGEEQFASHPPTGSQQEPSRPASSAHVSVRRDNPLIPPPSATCLPASPRSLQSLAGRSYNHSHQLHDAHRWYITPRVPLTTQLHTQPRTGYTCSPGPRGLLPEPSLVKVDSRAVLGRSDKPAVSVATHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1I4</accession>
    <name>A0A8J5N1I4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012106">
        <property type="protein sequence ID" value="KAG7171489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1I4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="107" mass="11643" checksum="0C0A91FBD89DF537" modified="2022-05-25" version="1">MANETENQQNQLNSSSGQVNGQVKHVKGYRKKGLVSEKVLLERLSDMSIEDDLLNPGITLSSVEDDDDDSPMEEGSPQPATKGTLKKSLSLVVPSLNLAEEPKRPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1V2</accession>
    <name>A0A8J5N1V2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flotillin-1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Flo1-L1</name>
        <name evidence="7" type="ORF">Hamer_G014781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1V2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016600">
        <property type="term" value="C:flotillin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901890">
        <property type="term" value="P:positive regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000049">
        <property type="term" value="P:positive regulation of cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070528">
        <property type="term" value="P:protein kinase C signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002090">
        <property type="term" value="P:regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF46">
        <property type="entry name" value="FLOTILLIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7171642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="325" mass="35491" checksum="D3BBDFF4ECD39C03" modified="2022-05-25" version="1">MLAGGRVLVFPGLQRWRRLSLNVMTIKVHSPGVYTVQGVALKVTGVAQVKISTQHPDVLAVACEHFLNKKQEEIHALITATLEGHQRGIMGTMTVEDIYKNRALFNSRVFEVASKDLYALGIHGYLKALGMAQTAQVKRDARIGEAEAKKDSEIQKSLAAETLLAAQYINKTLVAKAKRDFELQKAAYDQEVKSREAEANLAYELQSCKTKQKIQEEKMEIKVTYDSGEEGKNPGGATGDPMHGKTSDVTEKQPAEAAKYKLGFFMLNGVSTSLSNTKSIKMVSSGDSPVGAQKLTQEVINITCCVPDMVKNMTGVDILKTLSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N232</accession>
    <name>A0A8J5N232_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G030026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011708">
        <property type="protein sequence ID" value="KAG7171743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N232"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1248" mass="154206" checksum="E3D9DCBCAB97085E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2J8</accession>
    <name>A0A8J5N2J8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2J8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="789" mass="88983" checksum="4148C0B0D3981261" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2U0</accession>
    <name>A0A8J5N2U0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Roadkill-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rdx-L</name>
        <name evidence="8" type="ORF">Hamer_G009605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tdpoz family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2U0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18345">
        <property type="entry name" value="BTB_POZ_roadkill-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000028">
        <property type="entry name" value="Speckle-type POZ protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000008">
        <property type="entry name" value="Speckle-type POZ protein-like a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056423">
        <property type="entry name" value="BACK_BPM_SPOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24570">
        <property type="entry name" value="BACK_BPM_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="7">
        <location>
            <begin position="75"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="244"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7172252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="419" mass="46850" checksum="55AF02F92A57B997" modified="2022-05-25" version="1">MSLLGHHVQYYFKGLFKANNVGHAHSVHGGGGGGGGHVSSGGVSMSVSRVPSPLPPENNMPVAENWCYTQVKVIKFSYMWTINNFSFCREEMGEVLKSSTFSAGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSSNKSEVRAKFKFSILNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLYCEVSVVADSVNISGQSNAIHFKVPDCRLSDDLGSLFESQRFSDVTLSVSGREFQAHKAILAARSPVFAAMFAHEMEERKHNRVEIQDVDHEVLREMLRFIYTGKATNLEKMADDLLAAADKYALERLKVMCEEALCTNLSTENAADVLILADLHSADQLKAQAIEFINTHATDVMETQGWKSMIQSHPHLIAEAFRALATQQIPPIGPPRKRIKASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4J4</accession>
    <name>A0A8J5N4J4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4J4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="126" mass="14662" checksum="C7640E519CA92959" modified="2022-05-25" version="1">MKSSEGYRKALSTLKDRYGDEDAHIEELMMNLINGPPVKITNGEGLQDLAVELQACICSFESMDSQETLEHLLVKKDIIERLPGRLQERYEIAVLDHHPKRYGHMKIRDIWQFIQSREKEAKRAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4Y1</accession>
    <name>A0A8J5N4Y1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009433">
        <property type="protein sequence ID" value="KAG7173563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4Y1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="170" mass="18236" checksum="C0D9C2AA6F1F52ED" modified="2022-05-25" version="1">MKLSGRVLELNCLFLLVVALLVALQLFLQRAQQQLHVNKRNKGIGLVGPIALPLQDSVDMLQAGPGLGQDGEAVAPEDALVAAPFVPNIRKSFTKRKAPYVRKGKKNKKKKAQNKKNKQQKHGPHGEGEGRTGGPQGGGKLGNSKKPAGPRGEGKPMIKVAGIYRTLDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6X5</accession>
    <name>A0A8J5N6X5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphatidylserine decarboxylase proenzyme, mitochondrial</fullName>
            <ecNumber evidence="13">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="13">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="13">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="14" type="primary">PISD-L</name>
        <name evidence="14" type="ORF">Hamer_G003260</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="13">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase alpha chain</molecule>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="13">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase beta chain</molecule>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Single-pass membrane protein</topology>
            <orientation evidence="13">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="13">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="13"/>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6X5"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5035348655" description="Phosphatidylserine decarboxylase beta chain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035348654" description="Phosphatidylserine decarboxylase alpha chain" evidence="13">
        <location>
            <begin position="326"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="13">
        <location>
            <begin position="38"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="13">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="13">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="13">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="13">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="13">
        <location>
            <begin position="325"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="13">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7174322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="376" mass="42794" checksum="A5F509F6E79AC04B" modified="2022-05-25" version="1">MAQSSLKQYLRSLRWTPLPVGVGLALIAFQQYRHTRKREAAKLGQLEPCDCLADEWEVEAYKLLPLRSFSRAWGWVNGLELPEWSRKSVLGLFVRTYGCNMAEAEVEDLNKYKCLSELFRRTLKDGLRPLDMSASVVSPVDGRILSFGIVSCGMLDQVKGVSYPLRKFLGPNCWSEGGPMVVNKDDDDCFHRSCLRDCENNTLYQCVIYLAPGDYHRFHSCADWKVNFRRHFPGELLSVNPSIAAWVRNLFVLNERVTYVGHWKYGFLSMTAVGATNVGSVRVYFDDDLNTNEKKWNSSIFHDKYFKEKSIELSRGGEFGEFNLGSTVVLVFEAPKDTTICVDIGQKVRMGQALFRIPNSYVGKARSEIVHPGPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8J4</accession>
    <name>A0A8J5N8J4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Eif3h-L2</name>
        <name evidence="7" type="ORF">Hamer_G030699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007399">
        <property type="protein sequence ID" value="KAG7174683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8J4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7174683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="304" mass="35014" checksum="4C8028A87256C711" modified="2022-05-25" version="1">MKIIKHCHEEGAGNTEVAQGVLLGLVVDERLEITNCFPFPRHADDVDEEDYQLEMMRHLRKVNVDHLSVGWYQSTQLGNFITTQLLESQFSYQTSIEESVVLIYDPIKTARGFLSIKAYRLTPEAINTVQERDYTPEALKKMRLGFESLFQEIRLVVKNSHLVNTLLSELYELMPSSEGKQFLDLGTMSTLDRQLRCLMDYVDDLSQEANKFNNFQRQNAKQLQDKHKFMQKRAAENAQRQARGEPQLPDEDISKQFKPIAPLPRLDAMITSGQISNYCKQISQFCSQSLGKLYVAKALQQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8Z8</accession>
    <name>A0A8J5N8Z8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003971">
        <property type="protein sequence ID" value="KAG7176166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8Z8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="73" mass="8575" checksum="61B074F77D104718" modified="2022-05-25" version="1">MIRKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA89</accession>
    <name>A0A8J5NA89_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PIF1-like helicase-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA89"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="1">
        <location>
            <begin position="80"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="125" mass="13991" checksum="8158DF0A046C8931" modified="2022-05-25" version="1">MGCGNVEKSSTELTNMVYPNIIHHNKNNKWLRERAILAPKNETVAEINMTLLRLLPGSETSFKSVDIVIDQDQAVQYPAEFLNYLEIAGMPPHHLTLKIGTPIMLLRNLEPPILCNGTRLVITTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAI1</accession>
    <name>A0A8J5NAI1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fork head domain transcription factor slp2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">slp2-L2</name>
        <name evidence="5" type="ORF">Hamer_G017052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7176077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAI1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20021">
        <property type="entry name" value="FH_FOXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047208">
        <property type="entry name" value="FOXG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46617">
        <property type="entry name" value="FORKHEAD BOX PROTEIN G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46617:SF3">
        <property type="entry name" value="FORKHEAD BOX PROTEIN G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="145"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="145"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7176077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="499" mass="53992" checksum="C509207BF6876EEB" modified="2022-05-25" version="1">MEYLALGKILPPERNSALKILGTNQKAAERMVNLGCANTYGSSSSSNMDRTPLKHSFSISSLLSEAVLNAVPEGTPEQPTKDDDLCLQDFEMTAAVEDDEEDIDVTGAASPLAGIMSDSEVEEQHDKDEKEAKKEEGDDKKKHEKPHFSYNALIMMAIRSSPEKRLTLSGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSAEEVFIGSTTGKLRRRSTTASRNRLAAFKQSLLGRFGCYSPLGLAPYAAAAAAAAGLGGPLVALPGALSSGLASTTLYQQASAAAAAAALYRSYPPTYYHGMLPTSHMAPPGPPAGHPPPTGLPKPTALSPPPQQPPTSFSVEHLLSDAHPSAQPRNLLMGLGGLSSTAHYDAYRNSLLAQMGDAGRRHSLHRPVTVYPHHNTTPTPDSWDILIIKVSDKWSSCVCVRDSITSVAATPPSGTLSSTSVNIYNRITRETDEGSSAPEPPAASYNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBR9</accession>
    <name>A0A8J5NBR9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Corticotropin-releasing factor receptor 2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Crhr2-L1</name>
        <name evidence="8" type="ORF">Hamer_G009115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBR9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15041">
        <property type="entry name" value="7tmB1_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF15">
        <property type="entry name" value="DIURETIC HORMONE 44 RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="43"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7176323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="469" mass="52745" checksum="0640FC5FED8C03CE" modified="2022-05-25" version="1">MITFAYRECDGTGSWLRGGWTNYSQCLSVIENQGVRSGVLDAVRYITFIGALLSLLTLILTIFVFTYFRTLECDRLRVHRNLVVSLIVRFLVMLILTEPFIFHRHTTTYRDVDWLCKTLLALTMYAQMASINWMFVEGLFLHSRLTSNVFDSGAPFTLYYMIGWGWPMVFLAAWATTMALHYPVQCWRGYGNLPYVWILVAPMVTALMVGPPMITALMLSPPMVTALMVGPPRVTALTINLLFLINIVRILVTKLRASDAQVRKAIKATAVLFPLLGITNMLFAINPGDKGNLEGAYMLTNAILQSTQGVFVSVLYCFVNGEVQELLRKRWRQYRMRQLSQTGSPHRKSTRGTIIFEPSLSFRLSANTPSPLLMSPQTPNSQQMSSLMPTPLPLSPECTSSHFCTPQTPRSHHSNSQPLSIQPFDPKALKKHHLPRNQSSGPLLLRFHSSDHPSGATSQAEHDLMISSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCD0</accession>
    <name>A0A8J5NCD0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCD0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="172" mass="17966" checksum="29EDC515545135D2" modified="2022-05-25" version="1">MVVVVVCWCSGVEGTPLPIPQQVHTTAAALLGPVTGPRAPLAPAFTPEVAAARQAFLQEFNAQAAIAAQFPDDPDASQPTPIQHTPTQATQPSPPQLFTFPVAPTHPSQTNPAHRFTPTNVQAQSTTFHSSSNANSVGGGRSVVPIAPTFTIPEAYVQFHNLLIPPPTPTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCG8</accession>
    <name>A0A8J5NCG8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Tricalbin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCG8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="218" mass="23782" checksum="45B1851C8CDD1F0B" modified="2022-05-25" version="1" fragment="single">ASFLPSWTCCVHLWKCCSPLPTLDTLTHLQMRRGFAHPLRRFRSEANVREDPEVRPQENLDPRLELALSVGMPLRVGVGGGEGDASELLDGPLTHAKSQPNLLLMAPEAARLSSSAKVMSSNNSSSGHGQQRADVFVNVRGVAGMVQGLHIPRSGLQLFLRVRIRLAKPGTEGSVETWVNLQGGATLHLQASHGGQAPHTSRRRSLFRSWSLHKLGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCT3</accession>
    <name>A0A8J5NCT3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like-conjugating enzyme ATG3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Atg3-L2</name>
        <name evidence="10" type="ORF">Hamer_G016720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002318">
        <property type="protein sequence ID" value="KAG7177427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCT3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7177427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="132" mass="14934" checksum="400C1A18E5230145" modified="2022-05-25" version="1" fragment="single">MQNVINTVKGKALGVAEYLTPILKESRFKETGVLTPEEFVAAGDHLVHHCPTWRWAAGDGSKTKPYLPQEKQFLITKNVPCYKRCKQMEYRSEQELVLESEGDPDGGWVDTHHFSDSAILEEKVADMALEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NEI7</accession>
    <name>A0A8J5NEI7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NEI7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="225" mass="25866" checksum="F28C609696F41FAC" modified="2022-05-25" version="1">MTTPSQPQCDVHPPQPQVQCDHTSPQPQVQCDLHLHHNYRYSVDPHLHHNHRYMCNIHSLIHKYSVTYTFTITTGTVRPTPLQPQAQCDLHLHHNHRYSVTYTFTNHRYSVTYTFTITTELPNAILELTCERGNTVGDSAATPTHQQLDEENSWTDKQTRTMDYQLGLERVDLCWYQRGVGYQLVYVPSSYLMRVAQACPKVKLLNLVGPPCLAQVVQACHACRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T4I5</accession>
    <name>A0A8J5T4I5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate--cysteine ligase regulatory subunit-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Gclm-L</name>
        <name evidence="2" type="ORF">Hamer_G020101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010583">
        <property type="protein sequence ID" value="KAG7172546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T4I5"/>
    <dbReference type="OrthoDB" id="5596051at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="255" mass="27978" checksum="0C82491F303C12CB" modified="2022-05-25" version="1">MSAQPRVRKVILSTGNILEMEDLIRKAGQTTNEELRGSIKKTLNNWEGRKAEAQNGDVLTIQRSLNNVPPKENSGTKTTVKLFLSNTDSSQVEDAIKTVTTGLDLPHIDSVIVTPPDVSDDATLESLEPMWQALEDAVNRGVVTGIGLADVSTRLFTELYEWAKVKPTTMQVNLSSCCIVPQELSTFAQQHDIQVLTHNDPAEIVDEEVVSTITSCLGLSTGQCQIQWIARHRTIQQCFGLIQDKGYTLALACDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T4P7</accession>
    <name>A0A8J5T4P7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Atrial natriuretic peptide receptor 2-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Npr2-L3</name>
        <name evidence="12" type="ORF">Hamer_G006800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T4P7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="11">
        <location>
            <begin position="504"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7172591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="769" mass="87052" checksum="0E5B0985F79C8A4B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T6V5</accession>
    <name>A0A8J5T6V5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Galactokinase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GALK1-L</name>
        <name evidence="12" type="ORF">Hamer_G008544</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T6V5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000001">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="11">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="9">
        <location>
            <begin position="103"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="10">
        <location>
            <begin position="274"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7173026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="373" mass="40169" checksum="EE45408E41BF4811" modified="2022-05-25" version="1">MASKIPEVSSLVCEAQLAFKATYGGNADTAVSAPGRVNIIGEHTDYNDGFVFPMALPLVTVIIGRKTQSGLCRIQTLSEFADKPLQVAFKTPSSSAPLTRDVSGFDAVVTSSVPLGGGLSSSASLEVATYTFLESITGTKATSLREKALACQKAEHEFANMPCGIMDQFISTMGKRGNALLIDCRSLESTLVPLTDPSIAFVITNSNVRHTLSGTEYPTRRRQCQEAATVMGKKCLRDATLQDLEKHRSSLSEEVYKRAQHAISEIQRTEEAVSVLRNSDYTLFGKMMTESHNSLKDDYEVSCSELDELVAGALEVPGVFGSRMTGGGFGGCTVTLVKQECVDSLISHTLEKYSGKPTFYVCLPSEGTQQLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TGI2</accession>
    <name>A0A8J5TGI2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">ATP-dependent DNA helicase Q5</fullName>
            <ecNumber evidence="20">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">DNA 3'-5' helicase RecQ5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">DNA helicase, RecQ-like type 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">RecQ protein-like 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">RECQ5-L</name>
        <name evidence="29" type="ORF">Hamer_G003364</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="20"/>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045934">
        <property type="term" value="P:negative regulation of nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000444">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000614">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
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        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1429" mass="164000" checksum="17AF8F4406674990" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJT2</accession>
    <name>A0A8J5TJT2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Dusp16-L</name>
        <name evidence="9" type="ORF">Hamer_G014592</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
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            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1077"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1129"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1164"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1308"/>
            <end position="1321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7173267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1329" mass="145686" checksum="5F1380D0BB300C73" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJX5</accession>
    <name>A0A8J5TJX5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003479">
        <property type="protein sequence ID" value="KAG7176446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJX5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="258" mass="29357" checksum="864FED0CED018F2C" modified="2022-05-25" version="1" fragment="single">KLGQENEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDSSSDEQEATSDDNDDQLGDCSFHSRKVPPINVNATNLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGYVYSHERREASSTYRLPLELCGQPVDTNLLPQSTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKI3</accession>
    <name>A0A8J5TKI3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GDNF/GAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Hamer_G009043</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDNFR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKI3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057681">
        <property type="entry name" value="DUF7921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059035">
        <property type="entry name" value="Fn1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016017">
        <property type="entry name" value="GDNF/GAS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037193">
        <property type="entry name" value="GDNF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003438">
        <property type="entry name" value="GDNF_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269">
        <property type="entry name" value="GDNF RECEPTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269:SF12">
        <property type="entry name" value="GLIAL CELL LINE-DERIVED NEUROTROPHIC FAMILY RECEPTOR-LIKE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25537">
        <property type="entry name" value="DUF7921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25868">
        <property type="entry name" value="Fn1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02351">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110035">
        <property type="entry name" value="GDNF receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GDNF/GAS1" evidence="9">
        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type I" evidence="11">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7921" evidence="10">
        <location>
            <begin position="265"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7176265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="55410" checksum="DF67C45D6BEE3D79" modified="2022-05-25" version="1">MENNQDLALKIALCVCRNDSERSQARCMRGQRRLHPPCALMTDSMTDNQCHNLGRDCRSDRVCRYRLEHYELSCAADTMTGRCAGQHQECTKAMLSLLVESQLTYHLAQLGLDTEVLVSSFTDDHHDHHDQHQGEWGRQGDHHDQHQGEWGRQGDHHDQHQHQGEKDPAPQYPVGRGDNYHDDNGYDPVDDQKDANAKLMQVDGTRLQARKLYKEGDQDCSELCYCERHNHTKCKVSVAVPLPSDCSITRPLKHPDLLPPQVLECVENKPCETNFAVYNHNAPAYQAYRGECICYSGDFICQRPKPEEFELPTGLFLLLGFSKTEEALLRNVTGGTAIEALAPLQEIFTTISANMGVSITSPLEECRLEVFQHTRDNLVLQVRHIDVSSSVVNNTYTLNMLQEERNRCDRPISKVVKMINYREPKIHHDVRLSLFVLAEVIDTVPSPQRISGGQACPDSVGACWLAWVTGVALVLMGRLHTIDWRAASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLA5</accession>
    <name>A0A8J5TLA5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G008177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLA5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="355" mass="39740" checksum="3AAEBC93BD63110E" modified="2022-05-25" version="1">MRLQGAHDDPVVEVSWLLCSLPVSWTPKRQPFRLLGLVNASPTDEPHNIHFTQVEYSLAGNFTCEVSTANDVARQTYFLHVVDAFSSPYKTNVHVFEMINNSSGIKEENKFQYEVDGSDPSQNVNFENAACTLVWTFSTPAIFPRPNVTCGYYSFDYDDVIHRLPAGLTMHKFDNGSWQASFDSTHIEVLSIPRSHRLGCTVRIPDTTYKKVIKADDDFFIDNLIDSTGCPSLSLIHNLGLNVEVRDATYTCRDDILPADRSGTAVASLSCPDGHAAVFPEGVIKHDWNLELSCSENDIGWRTFSSEEHSKFDKFFDLNNLPYCEPRVFGSAHEVHAGSTYVLLTLLSLAAIFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLF2</accession>
    <name>A0A8J5TLF2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLF2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="8281" checksum="E8061C16A670C06F" modified="2022-05-25" version="1">MEICVVPYDCGLTDINEQLKDWNIRLINTVDQLKMYNNLLFRARGFCSTGRFYIIEDSPDSYVILKQSNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TQ59</accession>
    <name>A0A8J5TQ59_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutamate receptor 4-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Gria4-L5</name>
        <name evidence="9" type="ORF">Hamer_G015384</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TQ59"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7176583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="167" mass="17807" checksum="983BDCBB4B633150" modified="2022-05-25" version="1">MVLITNQMKGISDTLAGVVAGAASTSSLVPVLNLDFSMDGVCDTYKISQGFLGPTSLSLAFPKGSPLKARVNTVILRLKEFGILEHLALQEVSNATECLKPVSSTLGTGVLRPLEIGDFQGIFSIYIGGMLVALLTFLAELVINTVKEKYRSSLKESQTVDNLNICP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCF8</accession>
    <name>A0A8J5JCF8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UPF0518 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G012034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCF8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="3">
        <location>
            <begin position="819"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="602"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="920"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="693"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="920"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7155897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1039" mass="114896" checksum="451C819AAAADCEA1" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCK4</accession>
    <name>A0A8J5JCK4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCK4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="171" mass="18466" checksum="CB240B1D473B7293" modified="2022-05-25" version="1">MTSQPVCNRVEDQLVCSRVKNRSGFHGTMDQPVYHDAGDEPVRPTDQPLSTGRGSATLNRPTDQPLSTGRGSATLNRPTDQPLSTGRRSFTVNGPRVIHCQRAEDRPLSIGRGSATVNGPSISHCQRAKDQLLSTGRGSGTVNGSRIRYCQWVEDQVLSMGRGSASHRAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDI9</accession>
    <name>A0A8J5JDI9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative PDZ domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G014955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDI9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="87" mass="9099" checksum="FD577941CDE99E51" modified="2022-05-25" version="1" fragment="single">VSPPPPVSPTLSSPVTESSLTLILVVPVGDEILAVNGKSLSGLSHAEAIAVFKSIRAGKVIMHVGRRTSSNTRSSKSKSCDELDKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJC5</accession>
    <name>A0A8J5JJC5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein heavy chain 3, axonemal-like 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Dnah3-L25</name>
        <name evidence="3" type="ORF">Hamer_G029014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044975">
        <property type="protein sequence ID" value="KAG7154194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJC5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF70">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 2, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="2">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="149" mass="17194" checksum="88A8D7BF9193B9C6" modified="2022-05-25" version="1" fragment="single">MTLFGYFNERVRANLHLVVAMSPIGDTFRTRLRMFPSLINCCTIDWFTAWPDDALEMVATSLLQETKLEASLLAHCVTVCKYFHHSIDDLAHRYVTGLEKLKEAKLLITELQKELKLLQPRLVETSANTEALMIKIEQDTIQVERKKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJM8</accession>
    <name>A0A8J5JJM8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Organic solute transporter alpha-like protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">osta-3-L</name>
        <name evidence="7" type="ORF">Hamer_G022807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033239">
        <property type="protein sequence ID" value="KAG7159372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJM8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7159372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="319" mass="36371" checksum="1DBF7C6700DA845F" modified="2022-05-25" version="1" fragment="single">MSSDILSREINSTEVPTSSESECEDGYLPTVAEYREALDGYHTTMVVGGSILTVVLYALFLEQIVFIVRNVNKIFRRHIIWITSVYPFMTMMSVISIVIPRAETYTKAIKVTYMSAGISHFMDLTTLMFGSEKVMLHELQRSRFNLKVGPLCCCCFCFPSPKVTKSQLTVVRWLVWQQPYSQALYFMILLLWSTAESKEDGTIDPNSNYLWLCILDFLSFFCGIYALNVISILCRGHLDHYSYVYHNLDFLTRNPVHVEPSRQEKKQSISYLSGAQLHVSLSLSDDQLKETSGYGDLAMTVSQEPHSGYSPFHLDDCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKB5</accession>
    <name>A0A8J5JKB5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sdad1-L</name>
        <name evidence="3" type="ORF">Hamer_G015009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKB5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="2">
        <location>
            <begin position="54"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="311" mass="35782" checksum="584923735D7DEF56" modified="2022-05-25" version="1">MVSTAGLQVLDCDVSLSFFITLLKGGPVLPGQNERVPSGVDDHLEAAWFCVTSRNADKNLRQFLKQHIVTDIKNINSKGKNMKLNKELLNFMFEMLTSRHAIAAKTSLDVMIQLYNKRVWNDAKTVNILSMACFSKVTKIMVAAIKFFIGRDEEKTDETDSDSDPEDDQKVLKAARMSMKVNKKTKKKQRKMEKVKSVVKRNQKKKTTKVNFDFSALHLIHDPQDMADRLYKRLEKMNERFEVKLMTMDMISRLIGIHHLYIPNFYPLVQRFLFPHQREVTKVMVFAAQAAHAQVPPDDLEPVVPRLQTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKJ5</accession>
    <name>A0A8J5JKJ5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G018526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043933">
        <property type="protein sequence ID" value="KAG7154794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKJ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF46">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="196"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="329" mass="35625" checksum="E0769DA55903B775" modified="2022-05-25" version="1">MGVATDGVKATEEGWWEEGSAPQPQFENTPSNVTARVGDSAFLPCTVSNLGDRSVLHADDSNEWTLQIKFATIRDSGIYECHVNSDPKISRQVALLVRVPQSDLTVPQLDLTVPQPDLTVPQSDLTVPQSDLTVPQSDLTVPQLDLTVPQPCLTVSQPCLTVPQPGLIEPLLSPFTEHSQLDDPAFMGITTTTTHPTPVVLIEGPAERHIQAGSVLTLTCLIHHPPRQAPAHYHSAPPSPPCVSPQTEKFPRKTRSQVMLSNVRDSDSGEYSCSPSDLPPTVITVHVQHGQHQAAVQQGGLSAAPVANPVTHLLLLLLLMMLQRVKTWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLB6</accession>
    <name>A0A8J5JLB6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kv channel-interacting protein 4-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">KCNIP4-L2</name>
        <name evidence="6" type="ORF">Hamer_G022483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042381">
        <property type="protein sequence ID" value="KAG7155259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLB6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF167">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="235"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7155259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="281" mass="31771" checksum="5FB48AB11B45EEBA" modified="2022-05-25" version="1">MPRFTRLPRQPEEGGLNDGVTRCGRRATPRGSRLLCPGEVPNHDPDDIELNVVRYKPDGIDALARTTKFSKKELQLMYRGFKAECPNGIVSEDTFKGIYSQFFPQGDATAYAHYVFNTFDTDHQGSISFEASGGCMPPTSLTDKEEEEPGEETEELVLREEKVEHEEEKEEELRDFVTILSELSRGTMTEKLRWAFNLYDINGDGYITKEELLDIVTAIYSLVGRNATPAVEENTTQEHVDRIFEKLDINGDGMVTLDEFMEICTTDETIANSLTILDTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLV5</accession>
    <name>A0A8J5JLV5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006779</name>
        <name evidence="3" type="ORF">Hamer_G006781</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLV5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="87" mass="9424" checksum="CF2C4FCF6B812397" modified="2022-05-25" version="1">MTRHTGQWWVSESNSGSSVCQEMAIRLVATPQQEEQQEPTPGPLGVTHAHASTPTVSDHCHLPPSPTPSEADTHAYDDDDDDATTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNV9</accession>
    <name>A0A8J5JNV9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative extensin-2-like 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033008">
        <property type="protein sequence ID" value="KAG7159663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNV9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="269" mass="30098" checksum="3F5C7C01C5C2F409" modified="2022-05-25" version="1" fragment="single">SYGILGGILPYSGAASYRTLGRNPTVFWGRILPYSGTEYYRPLGQNTTVFWGRLLPYSEAESYPIVGRNPTVFWGGILPYSEVESYQILRQNPTVSWSGILQYSEVESYHLLGAESYRILRMNPTLFWDGMLPYSEAESYRLLGQNPTAESYPILGRPPTVFWGGILPSSGPKSYPILGRPPTVFWGGILPSSGAESYHLLERNPTVFLGGILPSPGVESYRVLGGILPYSRAVSYRILGRNPTVFWPKTLPYSGTEFYRLLARNPTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JP80</accession>
    <name>A0A8J5JP80_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen alpha-1(XV) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Col15A1-L</name>
        <name evidence="5" type="ORF">Hamer_G022210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032117">
        <property type="protein sequence ID" value="KAG7159828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JP80"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005594">
        <property type="term" value="C:collagen type IX trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010515">
        <property type="entry name" value="Collagenase_NC10/endostatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045463">
        <property type="entry name" value="XV/XVIII_trimerization_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF372">
        <property type="entry name" value="COLLAGEN ALPHA-1(XVI) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20010">
        <property type="entry name" value="Collagen_trimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06482">
        <property type="entry name" value="Endostatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0176">Collagen</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Collagen type XV/XVIII trimerization" evidence="4">
        <location>
            <begin position="561"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Collagenase NC10/endostatin" evidence="3">
        <location>
            <begin position="645"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="9"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="819"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="871"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="877"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7159828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="911" mass="94716" checksum="7DE98CA717C69647" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPD4</accession>
    <name>A0A8J5JPD4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase 11-interacting protein-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Stk11IP-L5</name>
        <name evidence="2" type="ORF">Hamer_G029598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038724">
        <property type="protein sequence ID" value="KAG7156804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPD4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="272" mass="30955" checksum="F9E365869BF1F7A7" modified="2022-05-25" version="1" fragment="single">LWDILNINQYLHSTDMWSLGEIQEAFSLILEIEQHTNFHVLPPNHRQHSAIPHLQFIYDRLQKIFGLRLWAKVGQSLPQNETISLRCFRNLQALELLHIPVTSLKALQTLRPTLRSVIIVKGLTRLSDLFIRCGADKAGEFTMSCEPTQLPALAPMQSLDHSLSLLPNLKILDLSHCELEDASALEYLPTVSLLDLSHNQLRLLPRLSPTATYSLIVLIANNNLFSHISGNGQPRRKSKKKRTRHIAITDPDNEDMDNDSIHLADSDMLERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ32</accession>
    <name>A0A8J5JQ32_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc transporter 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Slc30a6-L</name>
        <name evidence="14" type="ORF">Hamer_G022326</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway. As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer with SLC30A5; form a functional zinc ion transmembrane transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028009">
        <property type="protein sequence ID" value="KAG7162237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQ32"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052005">
        <property type="entry name" value="CDF_SLC30A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46531">
        <property type="entry name" value="ZINC TRANSPORTER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46531:SF1">
        <property type="entry name" value="ZINC TRANSPORTER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="13">
        <location>
            <begin position="55"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="446"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="525"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7162237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="541" mass="59490" checksum="4CABEFCB0B41769B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JR89</accession>
    <name>A0A8J5JR89_HOMAM</name>
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        <submittedName>
            <fullName evidence="4">Zinc finger protein castor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Casz1-L</name>
        <name evidence="4" type="ORF">Hamer_G021920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031566">
        <property type="protein sequence ID" value="KAG7160240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JR89"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045664">
        <property type="term" value="P:regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040373">
        <property type="entry name" value="CASZ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12451">
        <property type="entry name" value="TRANSCRIPTION FACTOR CASTOR PROTEIN MING -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12451:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN CASTOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
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        <location>
            <begin position="440"/>
            <end position="469"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
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        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7160240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="585" mass="64453" checksum="461812AF9F842632" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRE2</accession>
    <name>A0A8J5JRE2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cc8K15.2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030976">
        <property type="protein sequence ID" value="KAG7160713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRE2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="87673" checksum="4BA241DC069DA2C9" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRF2</accession>
    <name>A0A8J5JRF2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative helix-turn-helix HTH_28 domain containing protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HTH28-L8</name>
        <name evidence="4" type="ORF">Hamer_G029021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030464">
        <property type="protein sequence ID" value="KAG7161021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRF2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="3">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7161021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="291" mass="33298" checksum="793F885C25E1CFF5" modified="2022-05-25" version="1" fragment="single">MEVQPQHHVRPPRTRANRPEVITSRGRIIGYHEAGKGLREISRLLGISRDTVRLWVRRYEEEGHVLTRPRPGRPRVTTPAADQQIQRAAERAPLSTAISQRSRVLFVSQSRFRTLAGWVLFNMRTAFGDASSDWSEMLLMYYLVRMETTICLLPRPTSPTPLQYPSLDLANNTPPPRPPGSHTQHCETTTYQDQQRPYEPQRDRWWWDTRVPLNLAGISECEELYHRGLASHPLSSGHLQQCPHPQQQAEPPWETWLPCCSTSCVTQSSGCMMVSVASDVEIKVKEAETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JS35</accession>
    <name>A0A8J5JS35_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glutamate receptor ionotropic, delta-2-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Grid2-L12</name>
        <name evidence="15" type="ORF">Hamer_G004429</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JS35"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="216"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7163307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="611" mass="68838" checksum="C84FA031D7C2BF14" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSR8</accession>
    <name>A0A8J5JSR8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CGG triplet repeat-binding protein 1-like 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Cggbp1-L11</name>
        <name evidence="1" type="ORF">Hamer_G024574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029913">
        <property type="protein sequence ID" value="KAG7161110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSR8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033375">
        <property type="entry name" value="Cggbp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32344">
        <property type="entry name" value="U1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32344:SF1">
        <property type="entry name" value="U1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="342" mass="38290" checksum="570F29EBBBDFFE0A" modified="2022-05-25" version="1">MSTVIHLSLPQLSSVYQEFDAFTTDGSVLFCKYCEAPVTASKKFQVQQHLKTSKHIRLEAVKSNSAQKEQQLLLACSSKSGPDRSQFNADLCKAFVSADIPLHKLNNKCLKSFLEQYTGKKVPDESTLRKNYAPSRTARFSEIAPSTPLPPSPVVTRWGSWIDAATYYGKNFDVIEAVIATFDPEEAQSIQESKILLETEGIKESLLFIATNFVCISSTITRLEERGLLLSSAISLVNGVLDELKSLQSDAYYGKLSNVLYKNKGFEKLKKVSQIMSGDAIIDETVQPLTMSDLLCMKHAPIVSCDVERVFSEYKAMLTDNRRGFNFENLRHHVIIKCNHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JT22</accession>
    <name>A0A8J5JT22_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transforming growth factor beta receptor type 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Tgfbr3-L</name>
        <name evidence="12" type="ORF">Hamer_G016316</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JT22"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058899">
        <property type="entry name" value="TGFBR3/Endoglin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF45">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26060">
        <property type="entry name" value="TGFBR3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="751"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="11">
        <location>
            <begin position="417"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="703"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="778"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="711"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="800"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7161260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="814" mass="87436" checksum="3514360B0D5D8BC9" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JT55</accession>
    <name>A0A8J5JT55_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras association domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Rassf2-L</name>
        <name evidence="9" type="ORF">Hamer_G013946</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JT55"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09401">
        <property type="entry name" value="LIM_TLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01784">
        <property type="entry name" value="RA_RASSF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21886">
        <property type="entry name" value="SARAH_RASSF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000104">
        <property type="entry name" value="Ras association domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033614">
        <property type="entry name" value="RASSF1-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738:SF15">
        <property type="entry name" value="LD40758P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738">
        <property type="entry name" value="RASSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="7">
        <location>
            <begin position="421"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="8">
        <location>
            <begin position="502"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7161320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="552" mass="62811" checksum="511F7389112FCDF5" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV76</accession>
    <name>A0A8J5JV76_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ionotropic receptor 93a-like 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Ir93a-L16</name>
        <name evidence="1" type="ORF">Hamer_G007912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JV76"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="193" mass="22260" checksum="56E906F63C8BB32C" modified="2022-05-25" version="1" fragment="single">MLTTLVLTRSYAGNLMSLLAVRHIPQPYQSLRDVLDDPSVTMIWEANTKYVKYFRSVESGIFSEVAESEKRGLVKYTTPSHFVIDTDTLVRRGDHVFISEVLTIEVIMNYYFSQVGRCDFYWSKESFLVTIYALIAQKDSPIITAFNARMRQILDYGLLDQWYYTILRNSTACTHAPDKITISTSISLNNIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVB2</accession>
    <name>A0A8J5JVB2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G005194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVB2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="65" mass="7386" checksum="DBBB78A6D8CD9F8B" modified="2022-05-25" version="1">MDTRRWRDQSSGSALVNIIRMNAGLITQRLVVSVRDNSSLSLVVMSLSLENDSMRDFFSDHISTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVR0</accession>
    <name>A0A8J5JVR0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVR0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="162" mass="17090" checksum="E2EF846D788C6E2A" modified="2022-05-25" version="1">MAARSKMMSVRSDNGKSWEDDGSKHEYNDDSKSFDTKNDSKSKVTARNKMIRARSFDSKSDDSKSDGSDGSKNKGDDSKSDDSRYECSKSAARVMAARVNDGMMAVSKVSKGDVSKSNVMMAGRSDVSKSDGSKTLGWWCWGVVVVGGGGSVLVSSGGGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVR6</accession>
    <name>A0A8J5JVR6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G004839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVR6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="63" mass="6911" checksum="9393034CEB474102" modified="2022-05-25" version="1">MDDLTNIFHTSQTSGDAASKSVVVTTTNQDLPHIKMPLRFTSYDSSNTSSALDTTKTEYRAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW92</accession>
    <name>A0A8J5JW92_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G004554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW92"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="135" mass="15130" checksum="5F4C3323C02A3C2F" modified="2022-05-25" version="1">MKNKKNSNQHKPGEPTTGQLTELLTTITCLSEQLEENNTRPNPRNLIATALDKVMEEYKALYMSRVNARQQALITRYLCKAQPVNALANIALDDGITDDVIEVLGDILVEELPQYFERFVAEVRGGVEDGAGRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K173</accession>
    <name>A0A8J5K173_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G002225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K173"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7163149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="483" mass="51464" checksum="A268DF8D4258095B" modified="2022-05-25" version="1" fragment="single">MVPYHREGGGYWWILLLVMTLVVVVTEAGQGVLYLVGEANKRGTNLITSWVAASLSVCCLVCHKRVVSSETQCVGFNWVSSSRMCQTLSSLRNVVEDTTCNLYVPDSPSTSVELKFKCENCHGESTPAGLDSWVHQCEPWEESVVVGVAAFSSLSDLDYLLCKTFPGLMLDKTFAAAINDDRNCIDHISKGKTSFVTAAWADDQFFNNPKTFTHQCRGVSSETSAPPSPAASFTGPPSPAASSTEPPSPAASSTEPPSPTASFTEPPSPAASSTEPPSPAASSTEPPSPAASSTEPPSPAASSTEPPHLLPPTEPPHLLPHLLNLLHLLPHLLNLLTCCLIYSPAASLSSPAASSTEPPSPAASSTEPSSPAALSTEPSPAASLNLLHPLPPLLNLPHGLPPLLNLPHLLPPLPNLPHLLPPLLNLPHLLPPLLKLPHLLPHLLNLPHLLPCLLNLHLSFLDLTLTKQLNFILLKYFISLQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1U0</accession>
    <name>A0A8J5K1U0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative basic proline-rich protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G021781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019050">
        <property type="protein sequence ID" value="KAG7168767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1U0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="289" mass="28277" checksum="C09AA9C4FE5C9210" modified="2022-05-25" version="1">MRVVRLPSVWVCVREGHVATLEAEPASLGWKGPPGPPSEPHGPPSVGPTGFPNPATPNTFSGPSTPTFNPPGHTLNRPSPGPPTGPQGPASNPSNFPTGPGGPQPFNTPPNSFSGPPTSGPPSVPFPGSPAPSNASTPGPGGPSPFPGPPGGGPPTSLAATSMAGPGPSPMPFPCSSNYSSPTPTGPHMNGPNSTMGMLGQQQQAQMMNGPPGHPGPFPGPGGPGPGFTGPGGPFGPGGPPFGPGGPPGGPPMHGPMHGPMHGPGPHPMMGQLGPMDRIDQGILPGYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K477</accession>
    <name>A0A8J5K477_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G011133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K477"/>
    <dbReference type="OrthoDB" id="10602524at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035246750" evidence="3">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7166303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="188" mass="20664" checksum="BCE0CFE9CC360B26" modified="2022-05-25" version="1">MRLGCVLSVLVGVLAAGSALIPLPIPLPAVGPGPLIVAGLWSLKAIAILGYKKLQEDKQLREEEKEYENYESSYSRQKRAITQGEEEVEEAEKLLLSAATHLDTDGCVLKLLCHLNNKQVDALTLEETVLLQMFSDSPETMSSYNTTIQEDSEVDQGVCDKMFPNCPLTEEELGSLLRQTWGCGSLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4R1</accession>
    <name>A0A8J5K4R1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G005311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4R1"/>
    <dbReference type="OrthoDB" id="6352592at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035187380" evidence="2">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7167005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="195" mass="20973" checksum="C672981C8F620C3A" modified="2022-05-25" version="1">MKLQILLGVVMCVYTASAMPQTYEALGVLQPSTRDLGPYDNMVAATIDILPEIAQVFEQITSDPARSNNFDSGFVERVILAFLPISRKVMEAMAKAEGKSVQQEDLDRLARAEAIMPSILAFIEKLRTTDFYGIGEDFSGSAGSSGLGVSKGGSEPTAAATTRLTKTSKTNNLSASIVRMPNGGTHFINHPRSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5R3</accession>
    <name>A0A8J5K5R3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADP-ribosylation factor 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ARF1-L2</name>
        <name evidence="7" type="ORF">Hamer_G031969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014158">
        <property type="protein sequence ID" value="KAG7170430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5R3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7170430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="126" mass="14076" checksum="5E0765A5418013D9" modified="2022-05-25" version="1" fragment="single">MGLILSRILALVQSKKPCRILMVGLDGAGKTTVLYKLKLGEVVTTIPTIGFNVETVEYKNVSFTVWDVGGQERIRPLWRHYFQNTSAIIYVVDSNDPDRLAESREELELVVCIGQGCRNKSFISTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7C1</accession>
    <name>A0A8J5K7C1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative gag-polyprotein putative aspartyl protease-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G010984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7C1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="240" mass="26626" checksum="54D9F7D28573165D" modified="2022-05-25" version="1">MLRARLGLMEVDFLVDTGANASILPYDCVTRCGLTHHLDQSLRARLLNTVAEYQPTIRGRLRAQLHCSNGVVLEPFWVVLDPGIPILGMDVFTGYNCALSINSTHPKMFIQRPLRQNAARLANPVNVNCLIQSDLQQAGQTEWATLDTGSSCCFVSHTVAQQTRLTIIPLSSQTSSRIHTITGTAQMVGYAFAYLTFLGKVIHVRLCVKEHQDEAIIGLDALLALRLNMNFCVEEEEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7H6</accession>
    <name>A0A8J5K7H6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Mab-21 protein domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G011730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7169031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7H6"/>
    <dbReference type="OrthoDB" id="6336719at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="356" mass="40136" checksum="7E09E7EBD5BB0872" modified="2022-05-25" version="1">MSAVQMGVTPPGVTYVMSEVHKRQRDFLATECVATQVSHHLQRKLDLNSASFLSEAKFHFVGSAAENLVTSISDDRDLLLVLGPPYTLQYFKAVHEGHGRYFMKWNKCKWNGTKPRYVNDENYLSATSLRNHVTSCVRSSLEGATISEKKVVKILVWKQAVRVILKDEYDGTKHIVDVIPQIMGGKWSTVDGLVSLGSLEPELQKLITEIEAAGNSAILYSLFGAAGTSLHTFTTNYSILEREFFLKNHGLREVVMLAKLILSGHHWKDKYGIKAAHLKRVALGNITTLGQLNPWQGMQHLFHLMVSQLQTGYLDGFPDLHCDLLWHKTEEDCQYLAKAIMNVMMTLDPKFLANYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8L8</accession>
    <name>A0A8J5K8L8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Filamin-A-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cher-L2</name>
        <name evidence="6" type="ORF">Hamer_G010425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8L8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000140">
        <property type="entry name" value="FiLamiN (Actin binding protein) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000001">
        <property type="entry name" value="Filamin-C isoform b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035203444" evidence="5">
        <location>
            <begin position="21"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="117"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="255"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="351"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="463"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="565"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7166764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="644" mass="69477" checksum="6984C950D91D5A30" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KEU8</accession>
    <name>A0A8J5KEU8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KEU8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="373" mass="39486" checksum="0A0920E43BFA7FB7" modified="2022-05-25" version="1">MTEDVSSPSAVAAVAAAAVAGSSASSSSSTSSSSAGSEPSVNQKLFLVVSVALATVCFFTNIVQVAVFARPSVIRSVKSVLLLSQALRSVVGEEGYATCYLGHSAVILLTALTSLGSSTLLLFHQYMKVNDPRRFMTAGSNVVGWSVGVSAVWFVAIVVSVLPYAGWNSWEVHDARCHLSTLWPLSFTAFLTFLVGGHVAAALLMWASTRATQLKAMASRRGAAPPTNCPDAEEAPIANHVQGIHNNSSGSVRVGGWCVSVGSLVPMLAHVVVASSCAASRTCQASPSHYHEEAAALPWASLLLAAAAVTNPLLYVFTDDQVSSSTLLLLSRVCCWWCERRKQRLVPRHQEPHDAETNVYVTNDTDHLVSDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KFZ0</accession>
    <name>A0A8J5KFZ0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">M protein, serotype 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">emm6-L</name>
        <name evidence="4" type="ORF">Hamer_G012364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KFZ0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035186036" evidence="2">
        <location>
            <begin position="27"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="32"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7170125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="217" mass="23308" checksum="D25145BA3BD622F3" modified="2022-05-25" version="1" fragment="single">MGELRASWAVWVARAVLLTHISTVGGGPPPAHPPDGYCFKMHENNGVAHLSYPLVIASNSNSICQYRCYLLAQIYAATQGDVCRCENTVKTNSMDPGTCNFNCLGNDTQTCGGSDSGTFILVPASMVEPAGYAEAMGLMNEEPMNNTNTTTNNNNTTTNNNNTTTNNNNTTTNNNNTTTNNNNTTTNNNNTTTNNNNTTTNNNSNNTTSDNITLHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KG78</accession>
    <name>A0A8J5KG78_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WD repeat-containing protein 79</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Wrap53-L</name>
        <name evidence="4" type="ORF">Hamer_G013472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCAB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KG78"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00041558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7170653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="523" mass="59350" checksum="A0F432745DC2242D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KJK5</accession>
    <name>A0A8J5KJK5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase MINDY</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MINDY4B-L2</name>
        <name evidence="4" type="ORF">Hamer_G024094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MINDY deubiquitinase family. FAM188 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010016377">
        <property type="protein sequence ID" value="KAG7169479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KJK5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025257">
        <property type="entry name" value="MINDY-3/4_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039785">
        <property type="entry name" value="MINY3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473:SF8">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13898">
        <property type="entry name" value="MINDY-3_4_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01174">
        <property type="entry name" value="DUF4205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Deubiquitinating enzyme MINDY-3/4 conserved" evidence="3">
        <location>
            <begin position="5"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7169479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="320" mass="35808" checksum="9EFFD2CE9BEADEA7" modified="2022-05-25" version="1">MVALRRQVFGSADLLGSTENEWLGQSFVFHDGETVEAYSLKMHKTSTKGLAMCVQGFILKHLLFNRRGARVVADPTVLLRATTKAQEEALVGALSDILWRAGERQHAVLCLAQENIYVNDTPSYQSDGCTERIHTFEFKKQDELTFNLKKYLFEFLADEGNGLLLFLYSLVLSRGFNKLNEDMGGEEVSLLCTNAIIHPCLATLMLTGRATLFLHNGIIYEGSEDTMAKPKTGIITRAEVGLLVWRRPEEGGQVNVGSRLKTPSFPVWVTSTNQKSATIITIDTRNQTVKEEYNSPYLENLIHTKWQGADVNWNGTAPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJE6</accession>
    <name>A0A8J5MJE6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein 12-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Rbm12-L1</name>
        <name evidence="2" type="ORF">Hamer_G009309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJE6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035319459" evidence="1">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="111" mass="11216" checksum="0E08C98C0581BB28" modified="2022-05-25" version="1">MDVVLALALTAASAGTIYSAGLPYAGLPYSGLPYSGLPYAGLPYAGLPYAGLPLTGAQPYSGLPVAHASPVTYAAAAAPALVAPAPYSVHTQNKVEVAVEPVENHGYVIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJV7</accession>
    <name>A0A8J5MJV7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-antigen protein-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Sant-L10</name>
        <name evidence="3" type="ORF">Hamer_G020240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045202">
        <property type="protein sequence ID" value="KAG7154114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJV7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035275934" evidence="2">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="195" mass="16536" checksum="29FC19F94637BE18" modified="2022-05-25" version="1">MFVRVSMVVMVGLVGVCCAHWPAKKTYSYSGGSRRSSAASSAASSAASSSSSSSFSSAGSGALAGSGGKGSGSHGSAGGLGSGGSGGLGSSGGFGAGGSGGLGSSGAFGSGGSGGLGSSGGFGAGGSGGLGSSGAFGSGSSGGHGSSGAFGSSGSGGLGSSGASGSSGSGGLGSSGAFGSSGSKGHGSSGSFGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJX4</accession>
    <name>A0A8J5MJX4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin-like 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Clec-L14</name>
        <name evidence="3" type="ORF">Hamer_G020483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045000">
        <property type="protein sequence ID" value="KAG7154174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJX4"/>
    <dbReference type="OrthoDB" id="6355281at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035293253" evidence="1">
        <location>
            <begin position="18"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="27"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="152" mass="16906" checksum="5B76D2CAE46F4545" modified="2022-05-25" version="1">MKVVVVLVAALFSVVLADNCPQDYVAVGTSCYLFPDTKMTWQNAQDYCTSTAPDGTNADLAHVDKCGQLASLWDYILAHEPIVDYWIGGRDDDQEGVYRWEATGDPVLNEVPYWYPGQPDGGRQENCLSLSKTGYFADEDGSLHQKFICQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK23</accession>
    <name>A0A8J5MK23_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Collagen alpha-1(IV) chain-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Col4a1-L1</name>
        <name evidence="13" type="ORF">Hamer_G017518</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Trimers of two alpha 1(IV) and one alpha 2(IV) chain. Type IV collagen forms a mesh-like network linked through intermolecular interactions between 7S domains and between NC1 domains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044465">
        <property type="protein sequence ID" value="KAG7154326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.240.10:FF:000001">
        <property type="entry name" value="Collagen IV alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.240.10">
        <property type="entry name" value="Collagen IV, non-collagenous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001442">
        <property type="entry name" value="Collagen_IV_NC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036954">
        <property type="entry name" value="Collagen_IV_NC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF6">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01413">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00111">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51403">
        <property type="entry name" value="NC1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7 13" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035189011" evidence="11">
        <location>
            <begin position="29"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="domain" description="Collagen IV NC1" evidence="12">
        <location>
            <begin position="1320"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="56"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="281"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="357"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="514"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="984"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1252"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1084"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1127"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1287"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7154326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1577" mass="157591" checksum="F02B20A187509D4C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKE9</accession>
    <name>A0A8J5MKE9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tramtrack-like 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ttk-L11</name>
        <name evidence="8" type="ORF">Hamer_G018506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043933">
        <property type="protein sequence ID" value="KAG7154778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKE9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016199">
        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008406">
        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035167">
        <property type="term" value="P:larval lymph gland hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007526">
        <property type="term" value="P:larval somatic muscle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045476">
        <property type="term" value="P:nurse cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007464">
        <property type="term" value="P:R3/R4 cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045467">
        <property type="term" value="P:R7 cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF111">
        <property type="entry name" value="LONGITUDINALS LACKING PROTEIN, ISOFORMS F_I_K_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="52"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7154778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="371" mass="40532" checksum="A4E3850DDCF2976D" modified="2022-05-25" version="1">MDVGDDTTTQDTSGTPSSPTPSNQGLVGPYLLKKETHCSTVLDQLLRDDTYTDVTLTAEGQSLRAHRVVLCLASPYFRQVLSRELNIQSVVLLRDIKFAELRNIIHFIYTGEATVDASELESFMRTAEMLEISSLCEGQKCITGRGMQPHGSFSSGFSIADFERLVGTKRSRKETSPTPSKTRRVSGEGQSSRCSSAEPTATNNPLSLIKEEPDCENNTTFQKKKSKSLKEKELIDIEETNEEAGGGGRTRRESSGSVGGFAAIAGVQKVSSDTDDVGEVFPSTSESSPNSQGEESQTQSPVASVSDTIAAPGRCPYCPHLTQKYEGVAMMRHLLVSHPCKPAFPCDSCWRVFVKRINFKNHQQKCQTSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKS4</accession>
    <name>A0A8J5MKS4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G025297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042967">
        <property type="protein sequence ID" value="KAG7155153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKS4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="160" mass="16422" checksum="9870603D980131F2" modified="2022-05-25" version="1" fragment="single">AAEVVDLAAAVITAVVADLEAVVDLAAAVITAVVADLEAVVDLAAAVITAVVADLEAVVDLAAAVITAVVADLEAVVDLAAAVITAVVVVAAAAEVASEHNYRGPIIIPSPGLYLLYIPEFQVHPGRSLIPVFTLQVLGGKGDHHLHHQQIKMLSHYMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKY7</accession>
    <name>A0A8J5MKY7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043233">
        <property type="protein sequence ID" value="KAG7155060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKY7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="125" mass="12124" checksum="16A97E59635CD83E" modified="2022-05-25" version="1" fragment="single">DPEVCQCQDLMVCQCQDPEVCQCQDPNGLSVPGPNGLSVSGPSGRSETVTNGLSVPGPSGLSVPGPSGPSGLSVPGPSGLSVPGPSGLSVPGPNGLSVQDPVVCQCQDLILSVPGPNGLSVPGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLG9</accession>
    <name>A0A8J5MLG9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">START domain-containing protein 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Stard10-L</name>
        <name evidence="2" type="ORF">Hamer_G012040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLG9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="6"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="109"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="222" mass="25925" checksum="AC0336B4906AEEAF" modified="2022-05-25" version="1">MKSERQEEERRLEVRVADDRDFERLKQLCDCHDGWSLAYDHPPTKVYTRPTKNSTFQMIKVCTVYSDIDANVLYDVLHDPHYRQIWDKHMIHSVDVGYLNPNNDVSYYASYLIRPLPSGGCTFSYVSHCDPRGKLPPWLVNKLTHVLAPKMVKTLLKASRQYLTWKAHNNPNYKPWIYPEQINLPRIAFNQCTKSPADDIVDIVDESQVDEKSLAHLSNDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLR6</accession>
    <name>A0A8J5MLR6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD repeat-containing protein 82-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Wdr82-L</name>
        <name evidence="10" type="ORF">Hamer_G012037</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLR6"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032785">
        <property type="term" value="P:negative regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071027">
        <property type="term" value="P:nuclear RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000065">
        <property type="entry name" value="WD repeat-containing protein 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="246"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7155900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="314" mass="35084" checksum="49698A43CBB16CDD" modified="2022-05-25" version="1">MKLVDHVVRSFRVAKLFRDNTERINNIDFSPSGDLLLTSSDDDQIVIYDCEKGTSKRTLNSKKYGVDLIHFTHAKNSAIYSSTKIDDTIRYLSLHDNKYIRYFPGHTKKVITLSMSPIDDTFISGSLDKSLRLWDLRSPNCQGMMHVGGRPVAAFDPEGLIFAAGINSEMIKLYDLRSFDKGPFSTFQLSMEKECDWTGIKFSPDGKTILTSTNGSVIRLVDAFQGTPLKTFAGHLNNKGIPLEASFSPDSQFIFSGSTDGRVHVWNAETGYKVCVLNADHTGPVQCVQFNPKYMMLASGCTNMAFWLPALDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMV0</accession>
    <name>A0A8J5MMV0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative male reproductive-related protein B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G010072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMV0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="445" mass="48336" checksum="043E58A519F78CAE" modified="2022-05-25" version="1">MKKCLGLVCCFHSSEAHPASSSECDQFQIEKEILKIHTRDKVSFVEAINTALKYSSTPTPDYMPPILSPQTSLLMAEVHMDEAGTGATPHLSSTRHPGTTESPQKPNSKSQTLQQMLAQDGAPSSEMPNNPLPEVSCDETPAKIKLAEGTHGTGVTSTDPLSGEPPLRVNSGENMLGAYDHPPPEDIRLFNLFKIQNRCIMGVQPSLSQISVVYSIANYPSLPRCRQQLARFTSNKASEGVATTLFYCPPWKSSQHHSSPLMVRQGRLRLVQGTIFRANDGSSVAAPQEVAELFATAFASVSSTAARSSEFKRVSVFVCTALWVVSVSADQQSTVKPFLPEDFPYPGNIRTKQQTTVPPLPLSTPPPPPPFGIPSTCICYPLVTELPEGFVPALFNPAVPTEPVKENLIGLDSRSRSAARAVVTAPTYVQVFKDDTVDPRITKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMX3</accession>
    <name>A0A8J5MMX3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cation-dependent mannose-6-phosphate receptor-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">M6pr-L1</name>
        <name evidence="4" type="ORF">Hamer_G005842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMX3"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006622">
        <property type="term" value="P:protein targeting to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF29">
        <property type="entry name" value="CATION-DEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035152318" evidence="3">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7157418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="277" mass="30694" checksum="40301C12F68840B3" modified="2022-05-25" version="1">MMMVKVVVTVMVCVLELVNANKCVIDSSVPDQEKKTQYEYLKTLDPIIGKRSELKLSAKDTYTFVVCDDADPAFKNVSFIWNLGDTDSLLGFNNRTLVTKARNSLMLTFLGAKGLEGKYKKCNGTAGASHILFLCDHQQHKVQLEILEDFHGSLTCSMMFVVRHSCVCSLSNQGLSGGAIFFIILLVIFGSYFTFGFFYLRLVKGAKGVEQIPNREFWFKIGNMLADGCGAVFRCDRYCGARGTGSAPSSYGGYSPIDERLAQDLQDTDRDSSLLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MN01</accession>
    <name>A0A8J5MN01_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G005807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MN01"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="142" mass="15706" checksum="2088A8FCE14CB062" modified="2022-05-25" version="1">MSSQPSIRYWVRQGSATGPQVHCGCAHQHVGRGGPSHDADAGRSSSRSLTNHSFISYNLGEKRNERVSVDMVGGVARWRLVLVLLLLTPIAAPNKILFKISDGFGDNYMIAGYAMDDATDYQTLNITKTGYLYEDLGEHYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MP66</accession>
    <name>A0A8J5MP66_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G011376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MP66"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="103" mass="11267" checksum="EB4EA1B240085B18" modified="2022-05-25" version="1">MVGFCPKIGVGSYRILGHSPTVFSGGFLPSSRAVSYRILAQNPTVFWGRILPYSGAESYRNVGGIRPFSGAESYRLWGQNPTVCWHRILPFSGAISCRLLGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR98</accession>
    <name>A0A8J5MR98_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Germinal-center associated nuclear protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Mcm3ap-L</name>
        <name evidence="5" type="ORF">Hamer_G023575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030192">
        <property type="protein sequence ID" value="KAG7161063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031907">
        <property type="entry name" value="MCM3AP_GANP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16769">
        <property type="entry name" value="MCM3AP_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="390"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="944"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1676"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7161063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1736" mass="195756" checksum="11C0849EE6431DDD" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRE0</accession>
    <name>A0A8J5MRE0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ETSous factor-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ehf-L8</name>
        <name evidence="2" type="ORF">Hamer_G016232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRE0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="553" mass="61498" checksum="84C53BFBAA89484E" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRE6</accession>
    <name>A0A8J5MRE6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Natterin-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G016250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRE6"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12248">
        <property type="entry name" value="Methyltransf_FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Farnesoic acid O-methyl transferase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="325" mass="35766" checksum="CD00E929EEF2373C" modified="2022-05-25" version="1">MSVHFTEDCGDIRRYTFRRIKTSTIRFQVKAAHDVAVCLSSDDEEEPEDMYEIFIGCWGGGESGIRRKKHDDVCRIETPDIVTDEEFIGFWIKIQHGVIKVGRSGHKHAFMSYSDPETLLHATWYGYSTGWGAEGEWIFPDDDDDSSSSSSAMSSSDSEAEDLNDLDDRPIHYKRPARWVPAKGGYFPHHPVSGGEGPDGEVYVGMAHHEGGYILGMVVPDHGCCYIPFGGEAVPKSEYFVLSNPGSVTLTWEAGSKGKVPSGALQGGVSEDGESLFIGRVCVDGVVSVGKVHPSHEVCYLPYGGSEHAHKDYEVLCVRHVLCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRZ6</accession>
    <name>A0A8J5MRZ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tigger transposable element-derived protein 1-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TIGD1-L7</name>
        <name evidence="6" type="ORF">Hamer_G014043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRZ6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF26">
        <property type="entry name" value="TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="86"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="495"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7161404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="634" mass="71796" checksum="CD59BE152445A0BA" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSP6</accession>
    <name>A0A8J5MSP6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CycC-L</name>
        <name evidence="11" type="ORF">Hamer_G010820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSP6"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20514">
        <property type="entry name" value="CYCLIN_CCNC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000015">
        <property type="entry name" value="Putative cyclin-c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="10">
        <location>
            <begin position="46"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="10">
        <location>
            <begin position="157"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7162157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="267" mass="31487" checksum="57566D1EC8277963" modified="2022-05-25" version="1">MAGNFWQSAHYQQWLLDSQDLIQERRADLEVLTEEEYHKVMIFFANFIQQLGETLKLRQQVIATATTFLKRFYARNSLKCIDPLLLAPTSVFLSSKVEEFGVISNSRLISTCQTVVKNKFAYAYSSEFPYRTNHILECEFYLLESMDCCLIVYQPYRPLVQYMQDLGGEGEVLQLAWRIVNDSLRTDVCLLFPPYEIALSCIHMACVVHQKDCKQWFAELNTDLDRIMEITRYILNLYDLWKSYDERKEIQTLLQRMPKPNTQQVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSZ8</accession>
    <name>A0A8J5MSZ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G002175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSZ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF9">
        <property type="entry name" value="ZINC FINGER PROTEIN 862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="300" mass="34467" checksum="C4CAD75331B22A8B" modified="2022-05-25" version="1" fragment="single">MDAVKDVPLAKIDLLLLGIYQFYEKSSLNRSMLKQAHEICQLPFLSLEHTQKSYKAIVLHMQQTQNPNDTAYHKDLSRKAKKYLILLTSADVIKYIHLLLDILSCLRCLSEQFQHRQTNCLSTVDLLNKYLTSPGPSQRKILGGDTTIFQGEKLSYRYSTFTDARHDMLTSLNTKYSGNEGFGDTTVGALAQSLEKTLREAEVDPIKLEDEWAVLKCYLYKMNWHSSLTDDHLTDLLVVQLQSECISNFNPEQAINRFLTNGTRRVDGYNHTDGCNTEEVLDDIKELDKEHMQKLIDQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTY5</accession>
    <name>A0A8J5MTY5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTY5"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159:SF1">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="51799" checksum="BA6F1CA47E358A34" modified="2022-05-25" version="1">MTLLCSAEGRSGEALLQCPVMGQTLLAPGVALRTRHTHTHLTPNGDIPNGVIKPHDEADRNNRMDHKNIKQVTRLRSIGTSEGRASPRLKELLEGLNEPGDSGNLPEAPEWLDRELFNRGRQFYQRYLFCIFFSDLLSLLVMFSISRILRPLIYTERSDTPRRALRRYVSTIMHVITWFSGDVWDPLDHAHKDIMTVRSTHKNSAQIFNSSTHYEEVETMDVKKKKHEEPRCPIYPAICQDLQPQVRAGLVLESPDNSPVYISQWDMLITQYSFLGMMVAHPCRMGAWWVTENELAGLIHFWRGIGWLLGIEDKYNFCNGTVKETKALCHEIEQLVVKPRLSEVGWSHEHMASSLIDGMNYMVPGLSYPAMFRFLADSLDLAVPTFISHMSTFHTCQYWVLRFVFHVLFLVPGVVLLFNQLLKTAIRFIQNQNPSWFFKSHHPHFRGHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU81</accession>
    <name>A0A8J5MU81_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G002268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU81"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="214" mass="24119" checksum="0C0D2B2A1A5FF20A" modified="2022-05-25" version="1">MINKAACFPRCVCFWQLLAWLLHIPKLLRLKILPSSLLISALVPLLLRLLLLRLPRAVYLLRLPDGKPWVQISSVLASIIEWRSPLTLWWYRTPTKCSPRAPACGCSSTSMARRTLLTNSAERLKSSMPSVVTYPNSWTFKSNRSFYSVTETNSSSLSKGVERGNLSSVKSSWNCSFFRSSTLILFLSTRLVALVVRLGYNQATDSVCKVYSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXB0</accession>
    <name>A0A8J5MXB0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G011221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXB0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="92" mass="10363" checksum="6C6CF1B3603F5349" modified="2022-05-25" version="1">MKRNPTVFWSESDSFLGQNLTVFGDRILPSAGAESYRFLERYPTVSLGRILAYSGAKSYPILEQNPTILWGGILPYSVAESYRLQGRIPSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXF9</accession>
    <name>A0A8J5MXF9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="6">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ALAS2-L</name>
        <name evidence="8" type="ORF">Hamer_G005257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="6"/>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7166957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXF9"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048821">
        <property type="term" value="P:erythrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042541">
        <property type="term" value="P:hemoglobin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="185"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7166957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="586" mass="64535" checksum="CBD7E91F5832AF42" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXX6</accession>
    <name>A0A8J5MXX6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G012945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXX6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="121" mass="12779" checksum="01B3F58412E59EB6" modified="2022-05-25" version="1">MTSGDATAAPGVKIQGVDIMDLTSGIHVYEPSVVHVPLRFGEVYASWVKVAGLVQGWDLSEDAILQGSPNIVFTSLKIFLASVTITGSFRAASGLSGVDSDKSCSDLEFDKLLIKGKLYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYA8</accession>
    <name>A0A8J5MYA8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Glutamate-gated chloride channel-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">GluCa-L9</name>
        <name evidence="18" type="ORF">Hamer_G002362</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYA8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035328115" evidence="15">
        <location>
            <begin position="28"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="747"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="784"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="835"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="17">
        <location>
            <begin position="34"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="16">
        <location>
            <begin position="247"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7168338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="861" mass="99078" checksum="C44DD1C02B31DC55" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2L1</accession>
    <name>A0A8J5N2L1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2L1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035319468" evidence="1">
        <location>
            <begin position="30"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="214" mass="24822" checksum="33492CA326A17D1B" modified="2022-05-25" version="1">MSPTYGGSRSHVRWLLVWLLMVMLDSACSLFNTSRNFQIFGWNEVMETSANVCIFEVLYDRISFRWYSLLQRLKCVNHFILVLDTVKQMGTHIQHEIPHLTGHYCTSIEDTYVYNESTTGRKMHDRAKKHGTRTLMDKVAEAPKDKTIVVAGGFNQKETVVSYSQDVDTRQLEAMPEEPDTCRLILHCMQITTGTVLVHARRSDLFYQCYEEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N486</accession>
    <name>A0A8J5N486_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Espl1-L</name>
        <name evidence="6" type="ORF">Hamer_G008633</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N486"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="5">
        <location>
            <begin position="336"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7173107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="528" mass="59144" checksum="2072BC6A7FC3A157" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4W7</accession>
    <name>A0A8J5N4W7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Tigger transposable element-derived protein 1-like 336</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TIGD1-L336</name>
        <name evidence="2" type="ORF">Hamer_G030198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009757">
        <property type="protein sequence ID" value="KAG7173467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4W7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="76" mass="8779" checksum="34C4E48B487AFC9E" modified="2022-05-25" version="1" fragment="single">MLEVDTQLQRLEDNDYNAERSRIAVCGVKSFLAPYEQLLCERRKTAKQQTLDVFFKSTPKKQTEDTEPQPSTSGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5B8</accession>
    <name>A0A8J5N5B8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative olfactory ionotropic receptor IR4-like 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Ir4-L29</name>
        <name evidence="1" type="ORF">Hamer_G027506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009271">
        <property type="protein sequence ID" value="KAG7173617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5B8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="141" mass="14797" checksum="F3F3E0EC66462745" modified="2022-05-25" version="1" fragment="single">QNSNSLDAGPHTSFVSCTSSYQQVSCRICFANRKVEVMASLTPYLLLLAAIVLQATGKVSLPKGENDALTSAGEVVEAVLAATSHPRCSVFLLTDGTTSSVSNKLVTLPGPWGVGVFEVAVDGQDANITQTQLSRVVDEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5G9</accession>
    <name>A0A8J5N5G9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G008685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5G9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="66" mass="7559" checksum="27233C515AF9956E" modified="2022-05-25" version="1">MSSHTSSILSNDKHYSRKLSRSGLSLCLQIRLFVSPLLPTKVLNLRIKRAQKHKDPRPSDTLHCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5H0</accession>
    <name>A0A8J5N5H0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009549">
        <property type="protein sequence ID" value="KAG7173514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5H0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="22" mass="2478" checksum="A58F104998342D65" modified="2022-05-25" version="1">MRGGVQSKVSRGCRRDDIDEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N632</accession>
    <name>A0A8J5N632_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 10">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Tpi1a-L3</name>
        <name evidence="11" type="ORF">Hamer_G020022</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 10"/>
    <dbReference type="EMBL" id="JAHLQT010008712">
        <property type="protein sequence ID" value="KAG7173874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N632"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7173874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="321" mass="35302" checksum="138F1C591A640C2B" modified="2022-05-25" version="1">MVKTYSNVLCCTSGFGCIKVKDLTEAHTVALDPGLTSTVTPLLHYSTLNVFTMSSLRKFFVIGNWKMNVNKTRIDNIVKFMTAASLDPNTEAVVGCPSCYLSYARHHLPSEIGVAAQNCYKVPSGNFSGEISPAMIQDCGCEWVILGHPERRTIFNEPDELISEKVAHAQQAGMKVVACVCERKEDRDSNRTEEVLFRQMETLAASISDWSRVVVAFEALWASGTGILATPAQVQEVLAKLRYWLRHNVSQEVANATRIIYAGSVSSGNCQELAKLKDLDGFLVGSAALKPDIVDIINSRSTHVSRLINIFSSHERLSKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6C5</accession>
    <name>A0A8J5N6C5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Calcium-activated chloride channel regulator 1-like 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Clca1-L11</name>
        <name evidence="1" type="ORF">Hamer_G027718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008607">
        <property type="protein sequence ID" value="KAG7173905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6C5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="273" mass="30098" checksum="93BE214FF60E76CC" modified="2022-05-25" version="1" fragment="single">MSQAISQSGGIQLAGLSTIVWDDGNALINNGFITSRKRSLLPADRTRRALPVDPLERGDYCCGSVVPLDPAAATPTGDFFRFASGGSVQGSSIMRYVAINSVLETLQVTQTPTGDDALPPSRVTDLQVTYSHSTMNITWTAPGDDYDSGTALFVLPGTGLFSSHEEFFCHEKLSSTKPLLQFGVSIRKKKSNLGQIMESLATNPQIPHDVEVMLLNGAVVVNFLKPGVLKTFLEYEENVFMKYLMYQLQNLSKRLDIICNDYIPRRKRERSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6E5</accession>
    <name>A0A8J5N6E5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G017770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007950">
        <property type="protein sequence ID" value="KAG7174052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6E5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031985">
        <property type="entry name" value="DUF4787"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16029">
        <property type="entry name" value="DUF4787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035278847" evidence="2">
        <location>
            <begin position="19"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7174052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="162" mass="18379" checksum="89C9120FE65E22FD" modified="2022-05-25" version="1">MVLLAGLVALMAITCAQAQTVTYSFTQFPYKESVGNEKVWSEYEVACAQSPRCLELRGVHHTRCVRQCVSPSCYLDIYTHDEVSWRREKLMCVWHPSKVASFNECLDNDAPEATLTPSSPTPGPHQQRCPSAQTHWHRCGPGCSSGTWRRWRSWSTPGQEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6J5</accession>
    <name>A0A8J5N6J5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox protein prospero-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pros-L2</name>
        <name evidence="8" type="ORF">Hamer_G022345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008102">
        <property type="protein sequence ID" value="KAG7174025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6J5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Homeo-prospero domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023082">
        <property type="entry name" value="Homeo_prospero_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037131">
        <property type="entry name" value="Homeo_prospero_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039350">
        <property type="entry name" value="Prospero_homeodomain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12198:SF0">
        <property type="entry name" value="HOMEOBOX PROTEIN PROSPERO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12198">
        <property type="entry name" value="HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HPD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOMEO_PROSPERO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0371">Homeobox</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Prospero" evidence="7">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7174025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="88" mass="10138" checksum="FD379C6DDEEE43DD" modified="2022-05-25" version="1">MSSHSSTLTPMHLRKAKLMFFFVRYPSSSVLKTYFPDIKFNKNNTAQLVKWFSNFRCFYVHAGVTMCSRASTVKLFEAQNTRTGASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6L6</accession>
    <name>A0A8J5N6L6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mucin-5AC-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MUC5AC-L1</name>
        <name evidence="5" type="ORF">Hamer_G003055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6L6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
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        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
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        <property type="entry name" value="VWF_dom"/>
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        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF386">
        <property type="entry name" value="HEMOLECTIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="VWC_out"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWFD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VWFD" evidence="4">
        <location>
            <begin position="81"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="4">
        <location>
            <begin position="450"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7174163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="523" mass="57689" checksum="8C8ADD66CB0A937B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7G7</accession>
    <name>A0A8J5N7G7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enterin neuropeptides-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Enpp-L1</name>
        <name evidence="1" type="ORF">Hamer_G016405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7G7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="GOLGI-ASSOCIATED OLFACTORY SIGNALING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PERIAXIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="427" mass="46546" checksum="7201A10141B3E3A1" modified="2022-05-25" version="1">MAMTLLTLLTHLAMTLLILITHMAMTLLTLLTHMAMTLLTLLTHMAMTLNTVNSYGHNTVNTVDSYGHNTVNTVNSYGHDTVNTVDSYGHDTVNTVDSYGHDTVNTVDSYGHNTVNTIDSYSHDTVNTVNSYSHDTVNTVDSYGHNTVNTVNSYGHDTVNTVDSYGHDTVNTVNSYGHDTVNTVNSYGHDTVNTVNSYSHDTVNTVDSYGHNTVNNVNSYGHDTVNTVDSYGHDTVNTVNSYSHDTVNTVDSYGHNTVNTVNSYGHDTVNTVDSYGHDTVNTVNSYGHDTVNTVDSYGHDTVNTVNSYGHDTVNTVDSYGHDTVNTVNSYGHDTVNTVDSYGHNTVNTVDSYSHDTVNTVDSYGHDTVNTVNSYGHDTVNTVDSYGHDTVNTVNSYGHDTVNTDNSYGHDTVNTVYSYGHDTVNTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7I7</accession>
    <name>A0A8J5N7I7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TM2 domain-containing protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Tm2d-L2</name>
        <name evidence="11" type="ORF">Hamer_G016436</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7I7"/>
    <dbReference type="OrthoDB" id="408511at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF4">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035243886" evidence="9">
        <location>
            <begin position="33"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="10">
        <location>
            <begin position="130"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7174534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="197" mass="21869" checksum="73C472E6567906E6" modified="2022-05-25" version="1">MSVYHHSHTMHGVFTILLLLSAVSFIPSKILAEPPRPSEDLSSSEICIPHSPKVNCSFLPLEFLECEKPTDHRGNESARDDEGYGCVKFGGQRFEDVEITKVWCSVLDGIDCCGERRFLRDGFPCIKYSGHYFVTTLIYSVLLGFLGMDRFCLGQTGTAVGKLLTMGGVGIWWIVDIVLLITGSLTPEDGSNWNPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7T5</accession>
    <name>A0A8J5N7T5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hillarin-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Hil-L2</name>
        <name evidence="3" type="ORF">Hamer_G021919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006858">
        <property type="protein sequence ID" value="KAG7174817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7T5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056564">
        <property type="entry name" value="Ig-like_KY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF2">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23265">
        <property type="entry name" value="Ig-like_KY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="2">
        <location>
            <begin position="101"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7174817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="502" mass="57588" checksum="8824F9D5B44A0801" modified="2022-05-25" version="1">MVDVSVQTDNDILTDEAPEFAARPPQCKKSELLSSVNFTTIDAHALTIPREGTKDTAELVRYLCKPAADDLQRLRALFQWVTGNIRFDWKYMEIKQTVGEVLWSRAGVSKDYVALLVEMCHLAGLRVKKIHGFARGRDFRVGRVFEPERDPLHSWLAVFLYGSWRFLDPTLGSGHVDKQGKFHPHLQEHFFLTDPDYMIHSHFPYDNLEHNYNRWQLLDSPLSLEDFNSLPNVMPEFWSCGLKLCRPKHNPVVFRNQTEITVIAPTLIRYKYKFFPATETEESCINQWVFCTLKEGGAIGSFTILPPVNADYILKIYAGNEELLDDEGSALDHVVSFLLICEKARRYPVPWPTHDVAWGPTPRLYECGLDPVNQIGPVIVTWGGKKLIYFEKACDVMVMFQVFDTEGHMLDLKGIVGREETEEHLRLVIIPPGIGYYKFLIYGIPRPQVGGSVVQGRWRLPLLAAYLIECKMSLGNPKQELETHTNTNKTKNKRKIKVVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N858</accession>
    <name>A0A8J5N858_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Copper/zinc superoxide dismutase-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7174956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N858"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910:SF1">
        <property type="entry name" value="SUPEROXIDE DISMUTASE COPPER_ZINC BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="403" mass="44707" checksum="E162DD4D4C6F4FA8" modified="2022-05-25" version="1">MTSTKLVTWRGSMALWRASTGSVVNIMTLICSCLAQLPLWGGPSSSTRNIRMPGGSVAVLAGVTSPEARQVSAIASFHNPQGYAWGYIRMRQLIYFDGSFDETFIEVSLRHPGTNNRNLTRRHNWSVYVNPVGVDAGVKFFQSRCVAAGYRWNPYLIHLAFPNDRDYYERECGPEVPLRCDVGDLSGRLGTIDVGDKRYVFVDRNLPLSGPHGIMNRAMIIHRENAGVERFACANIRPDDDIIKWVIVRKTPKFTATTFMEDLREVLGAPEWYLAADLQTVSFSADQQCVTFVIHFMGPQAGQLELDFSRLLAGGILPSPTISIRGVYSDPKRPTKVPYRTCGGLEEDDILGDKSDASWWNVLTGNLDDVGYTGDGSGSSSSSFMSRPSFLHLLLLLLTVTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9D0</accession>
    <name>A0A8J5N9D0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine threonine protein kinase-like 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Putative serine threonine protein kinase-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G009198</name>
        <name evidence="3" type="ORF">Hamer_G009199</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9D0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7176392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="199" mass="21603" checksum="07040474A59E8CBD" modified="2022-05-25" version="1" fragment="single">MAGSATPLTATKVTRFRDAEMESMERMLSTKLISSFEMAMDIALEMDPNVDRSCTIIRNVKKDIQAYYEPNHQAPVHQPPHVHPNRTQLLGSCSRPQPSTNEPQPSTSEPQPSTSEPQPSTSEPQPSTSEPQPSTSEPQPSTSEPQPSTSGEQQFSVQIDSENESEVAADPGSEESEVAEDPGSEESEVAEDPSLLSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9F2</accession>
    <name>A0A8J5N9F2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9F2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="411" mass="47341" checksum="443C6C66CD4EAE93" modified="2022-05-25" version="1">MKSVTRGDVHQYTVEWSKHVVSPVETCTSTQWSGANTWCHQWRHGPELSGVEQTRGVTSEDMDQYSVEWNKHVVLPVETWTSTQWSGTNTWCYQWRHGPVHSGVEQTQKNAKDRRNYTDKELINDMIVPLLHQWTKANALFKPHVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDHLTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTGLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERREDDHDKRKVVKSVSSDNVLISDYDGKCGEMMEAQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9S5</accession>
    <name>A0A8J5N9S5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003591">
        <property type="protein sequence ID" value="KAG7176215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9S5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="56" mass="6174" checksum="8351ED491F7BA667" modified="2022-05-25" version="1" fragment="single">MQSTTIQLGVAVDLLKKTRDDIVSYRNTGFADALTIAKEICEAMSVDTVLKQKTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA76</accession>
    <name>A0A8J5NA76_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G029559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002656">
        <property type="protein sequence ID" value="KAG7176796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA76"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="8040" checksum="2838C1754773BBF1" modified="2022-05-25" version="1" fragment="single">MKIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBP1</accession>
    <name>A0A8J5NBP1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transient receptor potential-gamma protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Hamer_G023337</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003299">
        <property type="protein sequence ID" value="KAG7176486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBP1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="117"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7176486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="408" mass="46374" checksum="B9CC8833C7AF748A" modified="2022-05-25" version="1" fragment="single">MVFVAHPNVQQLLASIWYEGLPGFRRKNMALQALEIVKIGLLFPIFSIVYVLAPHTSLGQTMRKPFIKFICHSASYLTFLCLLILASQRIETVIVDWFGATPTLKKWVATDVTTRRGAPPSLVEWLILAWVFGLIWSEIKQLWDVGLREYVGDMWNVIDFITNALYVAYHSPQDRRLLPDNLPRQNWDTWDPMLIAEGLFAAANIFSSLKLVYIFSVNPYLGPLQVSLSRMVVDILKFIFLYLLTLFAFSCGEYEEIGREKGGENEAVRETERTNQSPNIGSLTPSSSTSGMNQLLWFYADLEKQTCDEEGQPQDNMTSGSGSGDEDSGPNIDSCIVWRRFSNLFETTQTLFWAAFGLIDLTNFELTGIKPFTRFWGMLMFGTYSVINVIVLLNLLIAMMNHSYQLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NC62</accession>
    <name>A0A8J5NC62_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NC62"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="103" mass="13273" checksum="4AB546AAFB2BD6CB" modified="2022-05-25" version="1">MKARKRKRKKKKKKERKRKKKKKKKERKRRRKKKKKKKKERKRKKKKKTERGRGRGRKRKKKKKKKKERKRKEEEEEEEEEREEEEGREEEEHPIRDAEVLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCF6</accession>
    <name>A0A8J5NCF6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCF6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7178191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="215" mass="25122" checksum="93602D3C410C22F3" modified="2022-05-25" version="1">MFTSELFEEAKLMGISEPTEIRNYVLTRQADECQDRAKEREERAKEREEQEKLFLYELEVWRIRSEEAEKARKHELAITTIKQDSPAQTPAVSSLPRVKLPMFDEQQTIEPYIQRFEDLAELYSFSESMKCLHFMSLVEGKPLEILHRISSNEKTYNMIKSALLKADGVKVDQARSQFPGATMQDKRTATQFAVRLTAYSNQWISMDETPDTKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCY7</accession>
    <name>A0A8J5NCY7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein 94-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Tmem94-L10</name>
        <name evidence="2" type="ORF">Hamer_G029370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002190">
        <property type="protein sequence ID" value="KAG7177477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCY7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="235" mass="27045" checksum="1F17BB0A1FBFB60F" modified="2022-05-25" version="1" fragment="single">LFVVFRRTADHSSQLRPNFPFKFYLSPYHVINNQEMACSADGLPTSEALSLLHEDISIALDEYQKTEAEKNKGFGPKSVLYEAFHHKSSLSVFHWTSVIALIVEGIVLLVAFAACNDPRYQHLPAESFFIFLAVILNVYLVWWDTQLRHKEVPRLTHNVLKDLKEYHGNVLWSAENYPHLHSPCITLQWTRRDGNTVNLPWSLLVRGDIILMKPGQKVPARCRPMQVSSIIFIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDP1</accession>
    <name>A0A8J5NDP1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Dpep1-L6</name>
        <name evidence="2" type="ORF">Hamer_G030379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010001531">
        <property type="protein sequence ID" value="KAG7177867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDP1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="82" mass="9045" checksum="2618A00FAC1FADE0" modified="2022-05-25" version="1" fragment="single">MNRLGLMVDLSHVSQATMKAALEVSRAPVIFSHSSVYSICKNPRNVPDHILRKVASNGGIVMISFYNYFLTCSKEATISDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NEB3</accession>
    <name>A0A8J5NEB3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pro-resilin-like 175</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G031939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001113">
        <property type="protein sequence ID" value="KAG7177919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NEB3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7177919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="146" mass="16301" checksum="9AE18569E2B76572" modified="2022-05-25" version="1" fragment="single">VIFLLGLVAVVAADKLPTSYGPPPQVSRYASSEEESDPPKYVYNWNVQDSYSGNDFAHQEDREDDNTKGSYTVQLPDGRLQTVTYYVDGDSGYVAEVSYQGEAQYPESEESREYAPPRPRYSAPQSEESVEAPVYSPPRRSYGAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NGD1</accession>
    <name>A0A8J5NGD1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tribbles 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TRIB2-L</name>
        <name evidence="3" type="ORF">Hamer_G020902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001665">
        <property type="protein sequence ID" value="KAG7177836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NGD1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031434">
        <property type="term" value="F:mitogen-activated protein kinase kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024104">
        <property type="entry name" value="Tribbles/Ser_Thr_kinase_40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961">
        <property type="entry name" value="SER/THR PROTEIN KINASE-TRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961:SF13">
        <property type="entry name" value="TRIBBLES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="180" mass="20456" checksum="F5D63A934B5ED793" modified="2022-05-25" version="1">MHKPECNFVYSFNRQHLELESLEDSVLVGDEDWLQDKHGCPAYVAPEILTFSSYSGRAADMWGLGVMLYTMLVGRYPFHDSVTSSLFAKIRCGEFKVPEWVSSRARHLITDLLRRDPARRLAVQDVLSHPWLTRPPRDHPPRDPSDHTVPTMYVQPSSHLSQSPKATATTSTYTPSLFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5SZP4</accession>
    <name>A0A8J5SZP4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G018602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012106">
        <property type="protein sequence ID" value="KAG7171481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5SZP4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035270225" evidence="2">
        <location>
            <begin position="16"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7171481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="187" mass="18185" checksum="97CDFB5B868B5233" modified="2022-05-25" version="1" fragment="single">LVGSAGLVVVGSAVSVVVVGNTASAGAGSLVGVSAGVVGIHGSAEVGAGIVGSAEVGAGIVGSAEVGWSVEVVGTVGSAEVVGTVGSAEVAVAVGTVESAEEGRVESVYGYGTGNPVHLEHFDGVRTGSTLEAAERGMLGITCSRDNVLVLTAGRLVLLVLVMSAWMGTGSYHPRPTTDASLGFSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T596</accession>
    <name>A0A8J5T596_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein TSR2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsr2-L</name>
        <name evidence="6" type="ORF">Hamer_G006884</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in 20S pre-rRNA processing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T596"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7172665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="187" mass="20942" checksum="89B1B31ABFD186B6" modified="2022-05-25" version="1">MYTSFKKAVAIVLGNWNPLQFAVQQQAGGKESAAIAEWMVGIVEQYFYENDDLEPEEVGDYLATIMDQELNTLVEDDSDVEVGKCLCHLYQLCVAGKDAQVMEELSKMPKCDLSLCSIREEPDGESEDDTPQLVAAHMSELQLNDTDNPTANSLSSQPPREITELEKQQHQDEGDGWTVIRKGNKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T5D5</accession>
    <name>A0A8J5T5D5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine ammonia-lyase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">HAL-L</name>
        <name evidence="3" type="ORF">Hamer_G008711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T5D5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021922">
        <property type="entry name" value="Par3/HAL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12053">
        <property type="entry name" value="Par3_HAL_N_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Par3/HAL N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7173174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="527" mass="57402" checksum="F41DDDCF15BCBA88" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T6Y5</accession>
    <name>A0A8J5T6Y5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010225">
        <property type="protein sequence ID" value="KAG7172860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T6Y5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="72" mass="8242" checksum="DA56B70994C16908" modified="2022-05-25" version="1">MVVALGNSRPGSDDDDVGELVEELRKELSTEELLELHKEENETLKPSLILRVIREDEDKEESRDYSSQRSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TEN8</accession>
    <name>A0A8J5TEN8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Myosin heavy chain, muscle-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Mhc-L3</name>
        <name evidence="15" type="ORF">Hamer_G003131</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TEN8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031033">
        <property type="term" value="P:myosin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000008">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000019">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000021">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000025">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000009">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000010">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF27">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8 12" id="KW-0518">Myosin</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin motor" evidence="14">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="130"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="896"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1008"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7174226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1203" mass="139256" checksum="44A6B814DA1063C9" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5THW4</accession>
    <name>A0A8J5THW4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DM4/DM12 family-like protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G022066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005701">
        <property type="protein sequence ID" value="KAG7175529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5THW4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035190338" evidence="2">
        <location>
            <begin position="22"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="192" mass="20918" checksum="D9F1B3ACCA0DF08E" modified="2022-05-25" version="1">MKMSYVMVPVALALLLGVASSTLVIPLATTAGTSLAITAGTGSLAGVAAAAAGVAGVGLVASALLSRRRGTVHQSLRIQYERYKRDVDEERLEELFAMVAKMDTHGCGMRHVCEVYKKPEHQLNLREHTIRALLGDKPEPVSPKKAKHPRSFYQSAAVLGREGQDCYNLYTSCPLTYEEVNEYLDNLDLQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5THW6</accession>
    <name>A0A8J5THW6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Down syndrome cell adhesion molecule-like protein 2-like 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Dscam2-L15</name>
        <name evidence="4" type="ORF">Hamer_G027482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011516">
        <property type="protein sequence ID" value="KAG7172368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5THW6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF173">
        <property type="entry name" value="FRAZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="108"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7172368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="544" mass="58020" checksum="1D4D61A8CF6BFDC2" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIS5</accession>
    <name>A0A8J5TIS5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA mismatch repair protein MSH2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA mismatch repair protein Msh2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">MutS protein homolog 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Msh2-L</name>
        <name evidence="14" type="ORF">Hamer_G017872</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010216">
        <property type="protein sequence ID" value="KAG7172893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIS5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000523">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="746"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7172893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="920" mass="101918" checksum="D6DF1CA7071FB0DD" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TRZ8</accession>
    <name>A0A8J5TRZ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002572">
        <property type="protein sequence ID" value="KAG7176808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TRZ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="375" mass="40592" checksum="315AA630F5D95706" modified="2022-05-25" version="1" fragment="single">MGSALEVFHEDLALGVDKHLKKIQEDQWLMQSRACTANQTSLSMIPASEAPALWRGQLLKTTDMMERSVVAASAVNVALLCCVAAPCCAVTALRFHWTDHTVRSLSFALLCCPPHLCAVSLPHTAAVPVLCHLLTLSSSNHLYTCAVSLLAVLCLAPHCAVTAPTMCCVTATLCSITALTLLDCPPHCAVSLPHLCAVPTLCCVTTFTHCAVPTLCRVTFYPTLLDRLYSVLSPRLVAIDRLYCCAVSLPCTFCASDRLLAIDNVHLMLMSCLHCCAVTRINSNRCFTAVNNHTVGNDPRTAVIACPTLRYAYGCCDWQVVAIGAETVPRVQDTVRVQDTVGETVPGVQGQCRVPGWRDHPTKIRHHPVGKLHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TUS7</accession>
    <name>A0A8J5TUS7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sestrin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SESN2-L</name>
        <name evidence="5" type="ORF">Hamer_G008230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sestrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TUS7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070728">
        <property type="term" value="F:L-leucine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016684">
        <property type="term" value="F:oxidoreductase activity, acting on peroxide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071233">
        <property type="term" value="P:cellular response to L-leucine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990253">
        <property type="term" value="P:cellular response to leucine starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901031">
        <property type="term" value="P:regulation of response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006730">
        <property type="entry name" value="Sestrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474">
        <property type="entry name" value="P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474:SF0">
        <property type="entry name" value="SESTRIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04636">
        <property type="entry name" value="PA26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7177588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="501" mass="55417" checksum="DCF793484732155C" modified="2022-05-25" version="1">MGHLVEQSEVAAIETQVSKATTTSATASSPQQTQQVQLGPVHLSQAQQQQQGEQQRQSGRGEGQAGQGQNHLAHTLSCHVPRHSLAKHSQLQQRVDETEGEKGENNEEEGNEEEENGWWAERVVGVLGGLGDYGDTWYRSHAHLLHVGWLMQALLTDFRNSGGDIRWIAGLHHAPPKIFALVPINNLLAHRPWLLMPQHIQELTKGEESWSLGELCQALCIMTHFHALATFLHGCGLSNPPRSSKKDEGQVVEREDCSNGKPTTTALQSRQGCPEPPHGTNSNVNCKLISRSQTKKGKAGDSTRHGIRAYAHLTVNPTLTYEDFNGNDESRIPSFSVHEYNWQDHGYAMCSRLLGEVGAFLDERFTSALSSTHLSPQKQPPKKGNVNQETIPVSGQTQCDKTHAKTLPLPTKALWNYVQWLLGIHHDDCDYADLNKHLDPQVKAFVKAACCYPESLADVHSSPSSTNSVQAHMIETSVVVMEARLQSELLYALRAVMLHQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TVJ0</accession>
    <name>A0A8J5TVJ0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SLIT-ROBO Rho GTPase-activating protein 2B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SRGAP2B-L</name>
        <name evidence="3" type="ORF">Hamer_G029897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001149">
        <property type="protein sequence ID" value="KAG7177917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TVJ0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051627">
        <property type="entry name" value="SLIT-ROBO_RhoGAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14166">
        <property type="entry name" value="SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCH" evidence="2">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="162" mass="18537" checksum="DA29A8DD3C85318C" modified="2022-05-25" version="1" fragment="single">TELRSQLNEQLRALDGRVDTQTALVNELQDWFRRRAELHQDYATKLDKLAKSLQARHKEQRIKRGSCTCSVSTAAGTRLVNQTVKDARDQYAMADVYLNNVIPRFTQVQDDTAGNKYMDAKLKALKARNEYILSMDSANAAIHKNSVEDLSDIVDHYNYDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TWB3</accession>
    <name>A0A8J5TWB3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000247">
        <property type="protein sequence ID" value="KAG7178277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TWB3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7178277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="58034" checksum="B96887217F4D83CB" modified="2022-05-25" version="1" fragment="single">MIYMGDFNTRYPELWVLSPNPNQNGIRLLEHIFRHQLSRRDNGSATHSRGGTLDHIIISGLVASHVNIFIHPYILLRPRRTQLPLLTPSWTSPIPSHIRLCIPPRNCPTCISYMSNLLPAFDLKSPEKSYSSLVNSTHNFHSHYVSRPHIKRRSEAYLMNVSSRRKRKWWRMVSHSKTSLGAMWHLINKVVKKKSSCALHHSPVEYAQGIVEIWSDQSQARNLPEHIQEAFSSQSNLRTLRLLAALLKVDEKDTVEITEEELRRALIRDKSRIFSPRNPGTLPEFIVGDGVILLCTRYIYLDAPVRITPVTPERQRVHSTVRDLIDQLQQRLTPLMWFTKKAAGIYIPVARTVYIIFILGCPTSTRRVNKQTEHNLPSLVKRTYAMSPASVSNVFTFPTLPPIILMSLAPPLTHIHLGLYFGQNLDIDTPVAEVDHDLPPWRIPCPALTFTHTSKADPPLLQKQLALETIHRVSTSIPVVHFLYTDGSLQADESGGALSSHWMWTHQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J209</accession>
    <name>A0A8J5J209_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U-scoloptoxin(01)-Er1a-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G019521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046868">
        <property type="protein sequence ID" value="KAG7153462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J209"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035245208" evidence="1">
        <location>
            <begin position="20"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="72"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7153462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="155" mass="17565" checksum="98C26785534297DD" modified="2022-05-25" version="1">MRWLGQSLATLTVVAMVVGVGNTAVADYSPDSPPQQVYDYRCQSTDNDPDADCIFGIAGQDYPTLRQVPDTKFTCVDLLPGIYADPDAACQVYHMCLHDGHVHSFLCPNGTVFHQEYFICDLWFNVDCNKAVDFYFLNEYIYKDPEPKEIRISYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDB0</accession>
    <name>A0A8J5JDB0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Ras association (RalGDS/AF-6) domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G006061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDB0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045742">
        <property type="term" value="P:positive regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045743">
        <property type="term" value="P:positive regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17043">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21298">
        <property type="entry name" value="GH01721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21298:SF2">
        <property type="entry name" value="GH01721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="111"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="343" mass="39052" checksum="741983D3CFAEA876" modified="2022-05-25" version="1">MSASSFMRKVTPDITELTTVRVWVRCLMQEMEYKTVCITYTTTCRELVHSIPKFKMKHRDPNLFYLTMEVTVRKTGGIMRTTLTLEDDSRPAELQSCHPRGDSRLALKMRPGGLVRVYDGALVPGSQYKSLLVSERTTCEELIRLVLLCNNIHNNVNNFSIYEVRRNDGRERKLHQDERPLRLTSRASLRRCSTKKINTNVHKTQNLPVSPAKPCSTSSTSPVEAPSDNMVPSTTITISPNGASTVTINTPTINTNLNNNNYCKSTNNIEETEKIEEPCPVPPLRSPRPVPPSRAAVRRQLPWTQSVDLVETPVDDDNDDELHANVRTRRAHSYNDYENYFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDD7</accession>
    <name>A0A8J5JDD7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDD7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="263" mass="30118" checksum="FD97EB80AC8E3B73" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANTLFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDSSSDEQEATSDDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDI1</accession>
    <name>A0A8J5JDI1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamate carboxypeptidase 2-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Folh1-L3</name>
        <name evidence="6" type="ORF">Hamer_G012032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDI1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000045">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF77">
        <property type="entry name" value="GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="154"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="314"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="4">
        <location>
            <begin position="549"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7155895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="614" mass="67962" checksum="E4E2FE31D121FD90" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JF94</accession>
    <name>A0A8J5JF94_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041707">
        <property type="protein sequence ID" value="KAG7155426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JF94"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="293" mass="33875" checksum="D0D893D2BE43D355" modified="2022-05-25" version="1">MENFTKIALTEFVKTGGGWDKFHRDLYAEATTETNVEEKFTGTADTADKLQENDKFADKQDFAEKFAEKFAQKFDEDKFADNTNKKYWSWRMLFPQQQTLLFFIKCFSQQQQQQQQQQQQQQQNECGDSWTFEDGLLIMGMGYLLGYLFNSVFLVAFMMAIMMIARSVIKRRSITVNSIKQQQQQQQQQNECGGSWTFRDGYIIMVMGCLLNSVELVVLVITAIMVFRRVIKRRSITVNSIRQDSLPDNDTLASSETPPPSYFELKIDDQKCCDYNSSITSMLTTPTPATVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGD9</accession>
    <name>A0A8J5JGD9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-directed DNA polymerase from mobile element jockey-like 35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G027141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039192">
        <property type="protein sequence ID" value="KAG7156239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGD9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="551"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="854" mass="96787" checksum="1C2561076FFE6E53" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGT1</accession>
    <name>A0A8J5JGT1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027228</name>
        <name evidence="1" type="ORF">Hamer_G028208</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045243">
        <property type="protein sequence ID" value="KAG7154108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010042093">
        <property type="protein sequence ID" value="KAG7155303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGT1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="119" mass="13329" checksum="0A0A0D57B2E4EE8C" modified="2022-05-25" version="1">MRSGECIRRENNAATRVEYSYATLGHVRFHLLKLGGFVWVAWDPEGIGRRSRPAVAVREIGRTGFHVAETKERHLPAEPQPAIKGTLGFDAHGPSARLLRRNKSSRLKSPLLPGWMCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGZ8</accession>
    <name>A0A8J5JGZ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Contactin-5-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Cntn5-L3</name>
        <name evidence="6" type="ORF">Hamer_G024246</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035861">
        <property type="protein sequence ID" value="KAG7158057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGZ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="131"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="223"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7158057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="468" mass="51532" checksum="C31C2B68C811FD28" modified="2022-05-25" version="1" fragment="single">LSTGLNEKYNYNYAGESYYYDYEVGEEDQPTFLARSQIFTVEVGQSVIIPCDVENAGNNKLIIKKVPAAGGKEKLLVVGNERVTKDRRITVEGSRLTISHARPRDAGIFLCMFEMDPPIQLKHTLDVQFAPSIRSLAPPEQHVAKGITVTLECKAQGNPEPTIRWSRQEGPLPSGLRSEEGKSLTLEGVDRHVEGTYLCTADNGIGESASAAMTIAAIVRTGEGDKVELVCLVRGRPSPDVTWTRDGHPLPDTDMDTKLYLPGGQNASTKDTHLRVTHAAHRHILTINKVSEKDFGAYVCIAENSHGQKDAVIQMTGRVGSPQAAAGNEQPQRRGEQQVHPHLADRKLLPNHRVHHQSNRTMVMAGSWENVSRSVEKDEVKVEDDTCHSMAFTVTGLEVATDYLAVIRVRNRYGWSSESQHFSFSTKKAMAVLQSTSGARSWTPASSPSSSSPLFYILLLLAFFLAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JH42</accession>
    <name>A0A8J5JH42_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039326">
        <property type="protein sequence ID" value="KAG7156221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JH42"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="177" mass="19746" checksum="DB28BE3D7EFEC788" modified="2022-05-25" version="1">MVKQPSTTTREYQPPTATREYQPPTATREYQPPTATREYQPPTTTREYQPPTATREYQPPTVTREYQLPTATRCPDTTPSLQCPHTTPSPQCHPHHTQPTVPPHHTQPTVPPTPHPAHSATYTTPSLQCPYTTPVYSALTPHPAYSAPTPHPAYSATYTTPSLQCLYTTPSLQCPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIU7</accession>
    <name>A0A8J5JIU7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein O-mannosyl-transferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Pomt2-L3</name>
        <name evidence="13" type="ORF">Hamer_G020304</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038254">
        <property type="protein sequence ID" value="KAG7157019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIU7"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="ArnT-like N-terminal" evidence="11">
        <location>
            <begin position="44"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Protein O-mannosyl-transferase C-terminal four TM" evidence="12">
        <location>
            <begin position="357"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7157019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="650" mass="74021" checksum="8F1EE5368075C111" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ99</accession>
    <name>A0A8J5JJ99_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Voltage-dependent L-type calcium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Cac1m-L1</name>
        <name evidence="19" type="ORF">Hamer_G006725</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJ99"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009582">
        <property type="term" value="P:detection of abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009581">
        <property type="term" value="P:detection of external stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042045">
        <property type="term" value="P:epithelial fluid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000007">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000107">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000001">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000010">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005446">
        <property type="entry name" value="VDCC_L_a1su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF1">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01630">
        <property type="entry name" value="LVDCCALPHA1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 15" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9 15" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="661"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="18">
        <location>
            <begin position="50"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="18">
        <location>
            <begin position="462"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="645"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG7156730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="723" mass="81996" checksum="B5AF40F9CBA32607" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJB1</accession>
    <name>A0A8J5JJB1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABHD18-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Abhd18-L</name>
        <name evidence="2" type="ORF">Hamer_G004167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJB1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019149">
        <property type="entry name" value="ABHD18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617:SF14">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09752">
        <property type="entry name" value="ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="509" mass="56798" checksum="56D6D15EE1F3086B" modified="2022-05-25" version="1">MVSRIDQIYRSILLTKFFVRGWGKPENLRRLFAFRKILSNRETCQQLVDKNHPITITKEVDNGDHIVLEAEFISPFVAHLPGLLPKESEKATFQLVFPKVWRTHLKPTCLHLAGTGDHGFWRRKMLMGKPLLDESGIASAILENPFYGCRKPKDQIRSSLHNVSDLFVMGGCLVLESLAIFNWCERLGFGPLGITGISMGGHMASLAATSWPKPLPLIPCLSWSTASGVFTQGVLSGAINWEMLKNQYFSNEVFREELFDMIQSPEGHFPVYHEVGQKFARDFPGSLSHVEQLMQDQGQNLRQHKHKLDDSHSDNKNEIRNSEFKSDDIRSAQNTRKSSQVEGSGSESQYYTGTVHNVAAGRGGGPLGISLSLPRFNILQSFGLSKSKVSKGQPAQANKDAATSSNHILVGYRKSKSNISKPVHEFTPVGIRPKSSANTKTVKFDPYMEVKDTLTWEAVQFMRGVMDECTHLGNFSVPVDPSLVIIVAAENDGQAIKDSFDQVIAKYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJN8</accession>
    <name>A0A8J5JJN8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Sulfite exporter TauE/SafE-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Hamer_G006303</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJN8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31154">
        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31154:SF4">
        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7158925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="436" mass="48925" checksum="77B343E56C86A7A2" modified="2022-05-25" version="1">MYEVGAAMRRGDGTTSRRFWSKWCHNGFSFWCKKYFWEGQLKQGAVDEGNENVTNTRGPLSGLSPSKRKLVGLLIPAAFFHFWYWSIMTYRNLFYVYETKYPMSITMVFGSIIAGMTSVGGGAIAFPVMTLVMKEPPEIARDLAMSLQANGMTAASFSIFFMKVHIERHALLFSLLGSSIGVIFGLEVIDPLLTPPMKKMGFVSIFFAFSFALFLINWNHKRTTFNNIPELNWWKRLLLFIFGFIGGIFTSFSGSGADICMFSLLTLFFKVSEKVSTPTSVVLMAMTSMVCWWWRTLVTGAMPQESWEYLLVVVPIVTIGAPFGALIGTHFHRLVLAACVYILNTMSLVSAFVIVPQTPVLVGGSIGLMVAMFIIYSVIYKLGDRMNMKYEKASIKAKEEAKMKADSANSLTQNDVPDHTRDNPAYIGSTEYISRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJT0</accession>
    <name>A0A8J5JJT0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium voltage-gated channel protein Shaw-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Shaw-L1</name>
        <name evidence="16" type="ORF">Hamer_G016028</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Shaw sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041065">
        <property type="protein sequence ID" value="KAG7155653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJT0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18416">
        <property type="entry name" value="BTB_Shaw-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000020">
        <property type="entry name" value="Potassium voltage-gated channel protein Shaw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF278">
        <property type="entry name" value="SHAW-LIKE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="15">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="528"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7155653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="567" mass="63913" checksum="4C1AF3F9863DA90C" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKF4</accession>
    <name>A0A8J5JKF4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Tigger transposable element-derived protein 1-like 232</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TIGD1-L232</name>
        <name evidence="2" type="ORF">Hamer_G019161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037402">
        <property type="protein sequence ID" value="KAG7157529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKF4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="147" mass="17162" checksum="73A9AF13FE006A7E" modified="2022-05-25" version="1">MTATVNRDILSLARQAGFDELESEDIEDVLASHTEELSNEDLQQLTEHSPIEDNDEEEPQRTLTSKRLAESFNMFQQPMPILIDDDPNRERNFHVQPGSERVKRFSYFKRNIWQQALLSRPLKHEEYSRKPAQPSSLFECTVQSKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMR5</accession>
    <name>A0A8J5JMR5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ataxin-7-like protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Atxn7l3-L</name>
        <name evidence="3" type="ORF">Hamer_G016241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMR5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051078">
        <property type="entry name" value="SGF11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367:SF1">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="223"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="362" mass="39125" checksum="E96F0DA698DE61ED" modified="2022-05-25" version="1">MCNPSVCLTVRCAHEDKVKFGHPEVEVEELGEGEEEEEEEGEEEEVEEVTSTGGWMVQAGGGGGGGRVGVDGNILSPLASPETLEAVAQMISQELLDDTILNVVFEIHQSVKTGLMVLELGTVEEEHKFLQVNAEGLDVFGQAPIKKQHENSSRIASRRIQNSTKENTHNHTGGSDDDDDDDWVSDRKRKKRDKNSPRRSKNAKIKSDSVSSSSSVESTLASGTTEEKRAMLKQICGVISEHTHKMCTRSLRCPQHSNEQRQAVRDQVLNGSSTETTTRAADSTSRGLGDTEDIHVDIDGLDDGQLASSWDNDHSNTTSPADSTSTNNSTSSLAKRSGSKSKKKSSSKSSKSSSSSHGSLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMZ6</accession>
    <name>A0A8J5JMZ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G027858</name>
        <name evidence="2" type="ORF">Hamer_G030681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046901">
        <property type="protein sequence ID" value="KAG7153444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010031161">
        <property type="protein sequence ID" value="KAG7160635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMZ6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7160635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="248" mass="28493" checksum="F20B4ADAA15F8C97" modified="2022-05-25" version="1" fragment="single">PLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPM3</accession>
    <name>A0A8J5JPM3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Gspt1-L</name>
        <name evidence="16" type="ORF">Hamer_G015869</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
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        <subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
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    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
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            <taxon>Arthropoda</taxon>
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            <taxon>Eucarida</taxon>
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            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="2686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2686" mass="298595" checksum="961B835D4DF27C09" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRD5</accession>
    <name>A0A8J5JRD5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U-scoloptoxin(01)-Er1a-like 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030986">
        <property type="protein sequence ID" value="KAG7160698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="263"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1355" mass="133413" checksum="3371E42F1F18463C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSR2</accession>
    <name>A0A8J5JSR2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Synaptojanin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SYNJ1-L</name>
        <name evidence="5" type="ORF">Hamer_G001567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSR2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015047">
        <property type="entry name" value="SYNJ1/2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08952">
        <property type="entry name" value="DUF1866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01165">
        <property type="entry name" value="DUF1866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035238112" evidence="2">
        <location>
            <begin position="22"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Synaptojanin-1/2 RNA recognition motif" evidence="4">
        <location>
            <begin position="168"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7160348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="645" mass="69344" checksum="25043CA6C0654C4B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSV2</accession>
    <name>A0A8J5JSV2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cathepsin L-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Catl-L1</name>
        <name evidence="10" type="ORF">Hamer_G001648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSV2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="132"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7160408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="348" mass="38419" checksum="2D1E90C7EB5119AE" modified="2022-05-25" version="1">MCKQRLSNSQLGVGTGRDEVPNSSSVSSRAGISIGRVFLLCCTGRVGGIQDVEESFRMKIFTENKHLIAAHNKLYATGQKPYRLRMNKYGDMLHQEFVSTMNGFRWNHTGSYKSSRLYTGASFIEPDDDVVLPKAVDWRDKGAVTPVKDQGQCGSCWSFSATGALEGQHFRQTGKLVSLSEQNLIDCSVKYGNNGCNGGLMDYAFQYIKDNGGIDTEGSYPYEGEDDNCRYNPRESGAEDKGFVDIREGNEHALKKAVATAGPVAIAIDASHHSFQFYHHGVYDEPECSSEQLDHGVLAVGYGTLNGTDYWLVKNSWSTTWGDEGYIKMRRNHHNQCGVASAASFPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSW7</accession>
    <name>A0A8J5JSW7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Chitin binding Peritrophin-A domain-containing protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G002857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSW7"/>
    <dbReference type="OrthoDB" id="6358202at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035253881" evidence="1">
        <location>
            <begin position="22"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="92"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="152"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7163636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="217" mass="24096" checksum="22E74CD98F7D3211" modified="2022-05-25" version="1">MSPSLLRLLIILVLGVAGVASEDSCLPDCTNRTAGENVPDPKNCHRYYTCLTNNEPSDVAFECEDDMKFDMNSLKCVNADNVTCSFCEPQCKYACAGMSPDETFFVANINDCTKYYLCGVYDDPFPLSCEPGTFFNGIKCVKDESQCCDPCIVVCESQFTEIADPTNCHNFYYCSQDKYYPEIDDLHTCPNGEVFSSKDSGCFYGANCTEPCVRTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JT24</accession>
    <name>A0A8J5JT24_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neural-cadherin-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CadN-L7</name>
        <name evidence="3" type="ORF">Hamer_G014112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JT24"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="153" mass="16214" checksum="B89006B537D9E248" modified="2022-05-25" version="1" fragment="single">FGGATILLADEGERELYNASLALLGGPGTGNPLLLQVDAEEGVHVGGSPEYLALSVLSVHRDYFDGCMDDLRISGRSLPLPPTLNTTAWGKVRRFQGVEGGCVAPPACANVTCSPPLTCVDTWRSYHCGCEEGRVVSGSGETCEDIDECSWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUW8</accession>
    <name>A0A8J5JUW8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0462 protein C4orf33-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G008101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0462 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUW8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31475">
        <property type="entry name" value="UPF0462 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31475:SF5">
        <property type="entry name" value="UPF0462 PROTEIN C4ORF33 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035146411" evidence="2">
        <location>
            <begin position="17"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7162543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="433" mass="48373" checksum="5168DB049A3BB59F" modified="2022-05-25" version="1">MGVLLLVLLYAASTRAAKTYTITTTWNGGAIDHKPVQLTLSPSSDQQYLELSIDAPFFNDPPSPPGPAGQAFYGLWNYEVVEAFFLNDDNQYLEVERVTIRHSLPLEVTTQRNPTTKSWTGLAKIPITYLPPTVTKFNAYAIHGSGKDRMYESLYPAPENASNPDFHALQYFQPINMSELLPDQPNAPMSELWEDALQGVFPYNITTTWNNLPVPNTPVQFTLQGFQAGVELNVTAPFYNDPAPNGTAGQPFYGLWDYEVVEMFFLNDNDEYLEVELGPWGEHLLLLLKGERNTIKHSLPLDFLVTERTMPIENKPGIWKGSAMIPPGYFPPNVTRMNAYAIHGVDDARDYQALHPAPNNDPDYPQPDFHRLSLFRAIDFEFQLSNNSEYSDVWLDAMASSSTTISVGSGHKALLVALLSLTVVGAAWFAGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV56</accession>
    <name>A0A8J5JV56_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tight junction-associated protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Tjap1-L</name>
        <name evidence="6" type="ORF">Hamer_G005060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JV56"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043441">
        <property type="entry name" value="Tjap1/BEGAIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28664">
        <property type="entry name" value="TIGHT JUNCTION-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28664:SF4">
        <property type="entry name" value="TIGHT JUNCTION-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="395"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="566"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="64"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7164670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="609" mass="66350" checksum="07D41B53B37CE5DE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVP7</accession>
    <name>A0A8J5JVP7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Complex I assembly factor ACAD9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Acad9-L</name>
        <name evidence="23" type="ORF">Hamer_G017226</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:47237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:71412"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:47241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>oxidized [electron-transfer flavoprotein] + hexadecanoyl-CoA + H(+) = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:43449"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tetradecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:47317"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVP7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000008">
        <property type="entry name" value="acyl-CoA dehydrogenase family member 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000006">
        <property type="entry name" value="very long-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000001">
        <property type="entry name" value="Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049448">
        <property type="entry name" value="ACAD9/ACADV-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF9">
        <property type="entry name" value="COMPLEX I ASSEMBLY FACTOR ACAD9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21343">
        <property type="entry name" value="ACAD9-ACADV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 17" id="KW-0274">FAD</keyword>
    <keyword evidence="5 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="21">
        <location>
            <begin position="105"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="20">
        <location>
            <begin position="208"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="19">
        <location>
            <begin position="321"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="ACAD9/ACADV-like C-terminal" evidence="22">
        <location>
            <begin position="516"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF21343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG7164836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="648" mass="71442" checksum="4AFAF4937451EFB9" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWN7</accession>
    <name>A0A8J5JWN7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kin of IRRE-like protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KIRREL3-L</name>
        <name evidence="8" type="ORF">Hamer_G021846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027556">
        <property type="protein sequence ID" value="KAG7162613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWN7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF154">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="66"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="177"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="264"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7162613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="639" mass="70991" checksum="154C605D7E7E88B8" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXA2</accession>
    <name>A0A8J5JXA2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RuvB-like helicase</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ruvbl2-L</name>
        <name evidence="15" type="ORF">Hamer_G019102</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="EMBL" id="JAHLQT010026149">
        <property type="protein sequence ID" value="KAG7163833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXA2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060828">
        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="66"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7163833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="487" mass="54078" checksum="F90C77C34D3EBABD" modified="2022-05-25" version="1">MAAVSLTSEEHEVTRIERIGAHSHIRGLGLTDDLTPKPLAQGMVGQVKARRAAGVVQNMIKDGKLAGQAILIAGQPGTGKTAIALGLSQSLGADTPFTAISASEIYSLGMSKTEVLTQAFRRSIGVRIKEETEIIEGEVVEVQIDRPATGTGAKVGKLTLKTTEMETIYDLGNKLIEALTKEKVQAGDVITIDKATGKITKLGRSFTRARDYDATGPQTRFVQCPEGELQKRKEVVHTVTLHEIDVINNRTQGFLALFSGDTGEIKGEVRQQINAKVAEWREEGKAELVPGVLFVDEVHMLDIECFSFLNRALEDDMAPVVIVATNRGRTRIRGTQNVSPHGIPIDMLDRMIIIRTLPYQEKEIREILKIRCEEEDCEIQDDALVVLTKIGLETSLRYSIQLITLANLAAIKRKEKQITIQDVKKVYQLFIDEQRSQKFLKEYEDEFMFDEGASLQRLSKCSAATSPARSIEKKKIKTFNLEDKVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXR3</accession>
    <name>A0A8J5JXR3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitogen-activated protein kinase kinase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MKK2-L</name>
        <name evidence="3" type="ORF">Hamer_G002148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXR3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="88"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7163078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="312" mass="34637" checksum="E5F04551C710B992" modified="2022-05-25" version="1">MVSIRKKLVSGWRQLRRLLTCTTRHNPSQKSFSPQPVPMVSYPSPPAPFSTHSSPHSPSHSSPHSSPEPPTRPTPPFDVLDIEELKKIPRLYRLGDGTFGCVDLVLYKGQVLAMKTHKGIIAKDLAKEVNYHLHLDGAGGAPRIHAVCLQSYAVLMDYTGVTYDKYLKIATPKEKLKSLIKIAESLCEIHDKHIIHNDLKVNNITVTFQGEEPELHLIDFGMATAPGTAVRRGDGCYWMAPDFEYGEAASSFSDIYSFGKLVCEVTETLSACSVLSDCLYRIVDLTQVEDPASREPLKEVIPTLYSFLNVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JY02</accession>
    <name>A0A8J5JY02_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein 714-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Znf714-L</name>
        <name evidence="8" type="ORF">Hamer_G026582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022345">
        <property type="protein sequence ID" value="KAG7166590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JY02"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF235">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7166590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="165" mass="18697" checksum="3EE3F78BE027F43D" modified="2022-05-25" version="1" fragment="single">MHTCMAEHTDEKDIKCEELDESFNSDYDVTQHVTVDEKDIKCEELDESFDSNYDVTQHVTVDEINIKCLKSVKSYDKKEQQKQHMAVHSGDEEDFKCEECGYDDDDGTTYDDIEVLGDLLVEELPQDLEGFDAEVRGVEEGAVTSPPCLRTHQPAPSSISLTPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYP2</accession>
    <name>A0A8J5JYP2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ANKRD2-L</name>
        <name evidence="5" type="ORF">Hamer_G010552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYP2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7166875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="243" mass="25223" checksum="D9E3135A0C42A397" modified="2022-05-25" version="1" fragment="single">PSSPTCDGWHPEPSSPTCDGGHPEPSSPTCDGGQPEPSSPTYDGGHPEPSSPTCNGVHAEPSVPTCGVSQGTNLYPILTDEVWGLDCAALVNEGDQLLVAAAEGKTREVKALVKQGANLEARSTNPGEEGHKDAAVKLINLGANPQALAGGRLAVHWAAYGGHVDVLKALSDLGCDLDVISADKSTALHLAADNGNFEAVQWLVEHGVSVHTLNGDTRTALDLAKASRFKAVSLYLKRKGKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYS8</accession>
    <name>A0A8J5JYS8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger protein 304-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Znf304-L</name>
        <name evidence="2" type="ORF">Hamer_G004754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYS8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="389" mass="43007" checksum="17092B348F43F150" modified="2022-05-25" version="1" fragment="single">CTQVYQYHNKNDTGVSVTEAHILVIIYSGNDLISTKLLKLTITLYQRHHPPTPATPSSNTSDTILQHQRRHPPVPATPSSNTSDTILQHQRRHPPTPATPSSNTSDTILQHQRRHPPTPVTPSSNTSDAILQYQRRHPPTPATPSSNTSNAILQHQRRHPPTPVTPSYKHQRHHLPTPVTPSYKHQRHHPPTPATPSSNTSDTILQHQRHHPPTPATPSSNTSDAILQHQRRHPPTPATPSSNTSDTILQHQRRHPPTPATPSSNTSDTILQHQRHHPPTPATPSSNTSDTILQHQRRHSPIPATPSSNTSNAILQHQRHHPPTPATPSSNTSNAILQHQRRHSPTPATPSSNTSDTILQHRCTLVTSPNVVVYGLSDLRLALLSLSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZE2</accession>
    <name>A0A8J5JZE2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynein regulatory complex subunit 7-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Drc7-L1</name>
        <name evidence="4" type="ORF">Hamer_G002886</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZE2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7163663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="452" mass="50517" checksum="33B8B325BFDD68B9" modified="2022-05-25" version="1">MGNTTVKDAVEGSEGNRSLDLSCKLTPSQYIKHTSGEFIEGCLSALPWEVYFNVSLYENVNASFNFINEIPVELSIHVPHLRSLNVSHNQICDLPTSFNLLLHLRVLDLSYNKLKMLPAALTRLPQLHTLNVANNYLKELPTTVSKLQNLKKLNVSNNQLRALPGCLVECPKLTVKASVFVRVRGQQVLASVSNPESASMEYRQAQGTSRTNKRKCPLMPPVNATTLKPDQLKNMLLGLLYGMAIGDAMALNTEGLTVDECIFFYDPENLSLDTRIYDYLRTHFPPHDWSSNTDIMILTLDSLMRWGGVVDELELASQLDQWRVHGYADLDPSPGYLLSPFMKKVITVEGYSANPHAAAQAIYKQTKDEISRGICTFNPSDNSCLPSALVLGVPNFYVDHEVEMNAERICKATHADPMAKATCIFLALLMATILQDFYAFLPYLDTFSKDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K069</accession>
    <name>A0A8J5K069_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">THO complex subunit 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Thoc7-L</name>
        <name evidence="4" type="ORF">Hamer_G017108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K069"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7167202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="169" mass="19015" checksum="4B7EE836110D8BB4" modified="2022-05-25" version="1">MIDGDGTGDARVMMIQNQYDRLLTQLAAIEHSSLRDETSTNVKEACIAIGSAKQELEEARQVRRNRLEYDALARLIKEHPPRSDTANKLAHLTQQLHSLKSKRDQLEEKLTLRRKQLHVLVTSLHELKQALLHDNSPSRDDEPCVIDEIIDLTAAPVAVDLTSTSMDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0I9</accession>
    <name>A0A8J5K0I9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Charged multivesicular body protein 2a-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Chmp2a-L2</name>
        <name evidence="3" type="ORF">Hamer_G028446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027022">
        <property type="protein sequence ID" value="KAG7162804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0I9"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7162804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="221" mass="25153" checksum="EC88EC24A433ED96" modified="2022-05-25" version="1">MPLEWLFGRKMTPEEMLRKNQRALTKAMRDLDRERSKMEQQEKKIIADIKKMAKMGQMDAVKVMAKDLVRTRRYTKKFIMMRAQIQAVSLKITTLKSQNAMAQAMKGVTKAMMNMNKQLKLPQIQQIMQEFEKQTEIMDMKEEMMNDVIDDAMGDEDDEEESDAIVSQVLDELGLQMTEGLSELPSAGGTLGTTAASKTPVAVADAADEDIQARLDNLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0T9</accession>
    <name>A0A8J5K0T9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron-sulfur cluster co-chaperone protein HscB-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Hscb-L</name>
        <name evidence="8" type="ORF">Hamer_G003698</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HscB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <name type="scientific">Homarus americanus</name>
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            <taxon>Decapoda</taxon>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="2595"/>
            <end position="2604"/>
        </location>
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        <location>
            <begin position="2607"/>
            <end position="2634"/>
        </location>
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            <begin position="2729"/>
            <end position="2744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="2778"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <begin position="2845"/>
            <end position="2858"/>
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        </location>
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            <end position="3226"/>
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            <begin position="3230"/>
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            <end position="3577"/>
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        <location>
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        <location>
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        <location>
            <begin position="3796"/>
            <end position="3809"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="3988" mass="435553" checksum="56809EBDF82C0FF3" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1D1</accession>
    <name>A0A8J5K1D1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ECSIT-L</name>
        <name evidence="13" type="ORF">Hamer_G013042</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ECSIT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:cell surface receptor protein serine/threonine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029342">
        <property type="entry name" value="ECIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010418">
        <property type="entry name" value="ECSIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046448">
        <property type="entry name" value="ECSIT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113">
        <property type="entry name" value="ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113:SF1">
        <property type="entry name" value="EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14784">
        <property type="entry name" value="ECSIT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06239">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ECSIT_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="ECSIT C-terminal" evidence="12">
        <location>
            <begin position="163"/>
            <end position="268"/>
        </location>
    </feature>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SMART" id="SM01284"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7167566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="290" mass="33367" checksum="432417EC4776CCDC" modified="2022-05-25" version="1">MASTSSLLWGRASSKFALQYVWNVSRRLQSPVFSNTFQKEHNEEKTSLTIQGYFASKDRSKETFLTACDVFRDKGPHLRGHLYKKLLNLMPKGKMIPQNMFQVEFMHYPKQQQCAIDCLEQMETHGVMPDTEMEQILLNAFECVSTKDVEDAIEDTWIVSGQSLVQQDLLNKHSPDEPIKVEGPFRIFLRDKCVGYFILRAEAKPRPPPLKRQEIDDVGDLKFWFTGEMQPDEEVAVYFWKDSLLSWIRLLENTNPNLANIPVLFTQASPIGDIMTTDEHDEPASVETVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3U5</accession>
    <name>A0A8J5K3U5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 13D-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">VPS13D-L3</name>
        <name evidence="4" type="ORF">Hamer_G005360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF141">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="799"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="960"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1461"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7167043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1588" mass="177324" checksum="AA98361CB1FA247F" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K404</accession>
    <name>A0A8J5K404_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G010365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K404"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="190" mass="20954" checksum="992EB9CA146A8472" modified="2022-05-25" version="1">MFRPVQEKEDSITIVLNEDKQEHDITVPIVHLEPETSVPPNIHETSSSRTYEVERCSSSNTRISVAATTEQRNRSHTPSATADDNQTRSTVTGDRPDELGSSPIPSTSHSTIRSDSRPQTTSGRKDEHFIPEMLHVQSQMRDSLVELVNSVHEGATQISSNMVKLVTKNKCIASALQTIAKAVQSKNPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4P3</accession>
    <name>A0A8J5K4P3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plexin-B-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PlexB-L2</name>
        <name evidence="2" type="ORF">Hamer_G020587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017093">
        <property type="protein sequence ID" value="KAG7169366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4P3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097374">
        <property type="term" value="P:sensory neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF44">
        <property type="entry name" value="PLEXIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08337">
        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plexin cytoplasmic RasGAP" evidence="1">
        <location>
            <begin position="10"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="130" mass="14772" checksum="87DA96E728B8418A" modified="2022-05-25" version="1" fragment="single">PSSSLQLRMNGCRPAMDSAMIQFEQLITNRYFLLALIETLEAQKTFNIRDIVNVASLLVVAMAGRMEYLTEILRLLLLRLIDKSVATKHPQLMLRRTESVVEKMLTNWMTLCMYTYLKVGGPVNPPPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K623</accession>
    <name>A0A8J5K623_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptide chain release factor N(5)-glutamine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.297</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Hemk1-L</name>
        <name evidence="8" type="ORF">Hamer_G013425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K623"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:peptide chain release factor N(5)-glutamine methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="RF_methyltr_PrmC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Release factor glutamine methyltransferase N-terminal" evidence="7">
        <location>
            <begin position="138"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase small" evidence="6">
        <location>
            <begin position="234"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7170610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="421" mass="48224" checksum="32F7974A39483C55" modified="2022-05-25" version="1">MKFRFRMAAVRLCSQRLRISSRQRCMSSYYRYSTCNTSSTEILVQDKSSQHSLKNQFECHTLSFINVNKKLPHQSCFFPKVTNILTSMKSVCKLPQNDIRYSPLSRLNIKHRPRYALHQSQTHTDRSYSTRADTVKDTLNDWTEKLEAADVPEASLAVEYIISHILDIPRMELHRYASLTLSEEMLTEIERLMTCRLARMPLQYILGEWDFHSITLKVRPPVFIPRPETEKLVELALECLQGIKAPRILEIGCGSGAICLSLLHILGDLHCVAVDQSKHAIEVTALNAASLRVTDRLTLVEGKVTSEKMPSLPQECFDLIISNPPYMLRKDLLNVQPEIMIYEDMRALDGGKEGLDVIKAVIKHSQHLLPGGHALLLEVDPCHCYLIPTWMEKQPTLKLNMSKVFQDFNGKDRFIKFVKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6U4</accession>
    <name>A0A8J5K6U4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UMP-CMP kinase 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Kcy-L2</name>
        <name evidence="5" type="ORF">Hamer_G020565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021277">
        <property type="protein sequence ID" value="KAG7167683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6U4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="499"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="506"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7167683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="587" mass="65144" checksum="3CA8185ABC146360" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8Y0</accession>
    <name>A0A8J5K8Y0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ionotropic receptor 25a-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ir25a-L4</name>
        <name evidence="2" type="ORF">Hamer_G028942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015862">
        <property type="protein sequence ID" value="KAG7169574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8Y0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="341" mass="38919" checksum="FD99DC68819AE5D4" modified="2022-05-25" version="1">MYVADIVNYFAVGSRDTISQILDAATANICVRSEVRLVQTVAENRHAPTRLRAYQPLRSTLWHFKYFMRRHLRRGVRRMAVRTSVPEVWFSRTIPVRDDFDLRSALQSVSMTNTWAVLAGGNGMSYPDVPLTMDKFKILTRTAGTQDLGEWSLGCPVHLCSSGQTLVISRYEIAPDGKFGTMDDNHEWNGMIKQLIEKVGTLNTPRELRLLYIFDQFPTATRTTRERYKDDDEKRVQPEGVSMVCVTSLRLVGAEGRFGEGEMNSRRWSETAREEEQEMEEEEEEIMGRGDGRSIIVSMLMSGYVFIGGGEAPRLSRLMATTWWLFGFIIIASYTVTWLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KAL1</accession>
    <name>A0A8J5KAL1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450 6k1-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Cyp6K1-L9</name>
        <name evidence="15" type="ORF">Hamer_G029546</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012894">
        <property type="protein sequence ID" value="KAG7171147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KAL1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7171147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="437" mass="50192" checksum="F13B595495362F24" modified="2022-05-25" version="1">MLFKYMLMFLFTQTYHENEGNNFVGAYEIFKPSLIVRDPGLVKRIMIQDFDHFSERRTISNSKKDECFREMLFLINGSHWKGVRSIMSPTFTSGRMRQMYHLVEEKADALIERLQRHCQEKSFVKTKTIYARYVMDVIGTCAFGIECNSINNEEEEFCKKASELNAISARGILRGIALLTLPNSVLNAIGISFTTPPFLFFQRVVEETIKNREMGVKRGDFLDLLLEQREEQSNSNTKTPKYPIKDSTIVAQSVLFLIVGHDTTAGTMAFVSYYLARNPHLQHRLRQELRDIVEEHGTLTYQTIMEAPFLDAIFSGDEQLPGTDVILKKGQHVTVPVWSLQNDPRYWTNPDQFLPDRFLPENNHNVISGTYLPFGLGPRNCIGMRFAFMEAKLALAKVILKFEMSLAPGHEELKLSVVAMKPTDDIMLVFKSLEDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KB12</accession>
    <name>A0A8J5KB12_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidyl peptidase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cathepsin C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Cathepsin J</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dipeptidyl peptidase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Dipeptidyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Ctsc-L3</name>
        <name evidence="15" type="ORF">Hamer_G023425</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012711">
        <property type="protein sequence ID" value="KAG7171207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KB12"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.80:FF:000003">
        <property type="entry name" value="Cathepsin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.80">
        <property type="entry name" value="Cathepsin C, exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014882">
        <property type="entry name" value="CathepsinC_exc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036496">
        <property type="entry name" value="CathepsinC_exc_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08773">
        <property type="entry name" value="CathepsinC_exc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75001">
        <property type="entry name" value="Dipeptidyl peptidase I (cathepsin C), exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035293227" description="Dipeptidyl peptidase 1" evidence="13">
        <location>
            <begin position="18"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="14">
        <location>
            <begin position="219"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7171207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="470" mass="53095" checksum="ECAB1F9B00E221AF" modified="2022-05-25" version="1">MLTRVVLALCCVAVALADTPANCLYEDVRGTWTFSETERTGDHTINCDELGPIVHTKTFTLSFPNVAKDELNNEGTWTMIYNQGFEVNINERSYFAFSYYEGDMDSAVSYCDRTFSGWSRDKTIRNWSCYTAQKLNKTAPRVTYNNLKALSTRLYKNDHKMIEDINASQSSWRGKAYLQHESYTVEEMYRRAGGRRTIRHIQPKPAPASPEQKRRVAALPENFDWRDVDGENYVSDVRDQGACGSCYIFSSMGMMEARVRIATRNQRQDVFSPQDVVTCSKLSQGCEGGFEYLVAGRYAQDQGIVAEKCNPYKAEDGPCNRDLSCELTYVSEYDYVGGFFGACNEEVMMLALVENGPITLAFMVYDDFMSYSGGIYHHTGLSNGFNPLEVCVCDVLCCYRTMYKHAGRVCDTNHGVLLVGYGVEAETGEKFWSVKNSWGPKWGEEGYFRVRRGTDECGVESEATQVTVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KDK8</accession>
    <name>A0A8J5KDK8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G013391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015640">
        <property type="protein sequence ID" value="KAG7169753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KDK8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="288" mass="32740" checksum="048898CB2372C81B" modified="2022-05-25" version="1" fragment="single">MTMNTNLYLSPSPWGCIGRYGRAHGVSSPVGRGTTPKETRVGERNIRQRLRQVPVTLCLMVVVLVVRGVECDPGPHYHHHAGEGVAVHPGGGTSYVRGVGKRSADPGPEPEPEPLASAEPHNPYYGYRYPYYGHHYLRRYGYGYPHSHYHKTVHKHHKRSADPSPSPEPEPEALASAEPHNPYYGYRYPYYGHHYLHRRYGYGYPHSHYHKTAHKHHKRSADPSPSPEPEPEPEALASAEPHNPYYGYRYPYYGHHYPHTAATVTVTPTHSHKTAHKHHKRSQTLTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KDQ2</accession>
    <name>A0A8J5KDQ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ataxin-2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Atxn2-L1</name>
        <name evidence="4" type="ORF">Hamer_G018461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7168024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KDQ2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009818">
        <property type="entry name" value="PAM2_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07145">
        <property type="entry name" value="PAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="3">
        <location>
            <begin position="172"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="539"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7168024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="726" mass="80525" checksum="54B153DE18708EED" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KEI6</accession>
    <name>A0A8J5KEI6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase subunit gamma-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">tam-L</name>
        <name evidence="15" type="ORF">Hamer_G023885</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="15">Heart &amp; testis</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
            <location evidence="2">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013480">
        <property type="protein sequence ID" value="KAG7170816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KEI6"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000024">
        <property type="entry name" value="DNA polymerase gamma, catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000002">
        <property type="entry name" value="DNA polymerase gamma, catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="14">
        <location>
            <begin position="990"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="229"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7170816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1274" mass="145294" checksum="8A25AB2D96236824" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KER5</accession>
    <name>A0A8J5KER5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KER5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="60" mass="7093" checksum="1E676034A2CD1989" modified="2022-05-25" version="1" fragment="single">MKSKEEEERSKRETDRHNSRGTFLRPVCCSSGQQDDPEERPPAQGQLHPHQKERPTERHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KMY1</accession>
    <name>A0A8J5KMY1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cuticle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CP575-L3</name>
        <name evidence="4" type="ORF">Hamer_G023996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013974">
        <property type="protein sequence ID" value="KAG7170529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KMY1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7170529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="123" mass="13978" checksum="DFD366AEDD5D1179" modified="2022-05-25" version="1">MMIVLGVVAMAAARPSDIIDIEEDHLEHEQEGVPGTAVEGEYSWVAPDGNEYKIKYVADHFGYRVVEDNVVPQFRALEVADPAPKIEEEEEDEEPVIRDSDMEEEEMIDIRAAEDMKKDEEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJF9</accession>
    <name>A0A8J5MJF9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G019513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046868">
        <property type="protein sequence ID" value="KAG7153457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJF9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="35" mass="4191" checksum="F9A45D678E5CFBBB" modified="2022-05-25" version="1">MEGCGWEEEVVRRKSVWLGRRPYNSKRLAEQQVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKE4</accession>
    <name>A0A8J5MKE4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043959">
        <property type="protein sequence ID" value="KAG7154763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKE4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="263" mass="30289" checksum="E1E2671AA63FED2F" modified="2022-05-25" version="1">MQEQRTQRRCIETKGFLEFVNQKLQITGCKTDVILRDDLYHKYKMYCKCRGLMPATIVNVGRTLAKKGVKSPSRIGGINGKGQKYGYTGIVFQPCMEVVPWHPYSAVYSMHSDSVISGKRKLEEQDQNEPKRAKITGKIIDPISTFLESFVSTSLDHKELVRQNDLFNEYREYCRQNGLEGYNNIKLGRLMTARGFKPTVRVGKPNSQQYCYPGLKWTREAPSGNNYTNLKQQRCHPVCPDRVISETKRYLLICLAIQFVNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKK6</accession>
    <name>A0A8J5MKK6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ectonucleotide pyrophosphatase/phosphodiesterase family member 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Enpp2-L</name>
        <name evidence="6" type="ORF">Hamer_G021969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043253">
        <property type="protein sequence ID" value="KAG7154958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKK6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF114">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE C27A7.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="5">
        <location>
            <begin position="587"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="503"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="507"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7154958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="876" mass="97441" checksum="422C8C6B38CAC065" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ML42</accession>
    <name>A0A8J5ML42_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G032045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042578">
        <property type="protein sequence ID" value="KAG7155212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ML42"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="39"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="104"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="176"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="248"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="327"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7155212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="406" mass="44193" checksum="CE57B467D41F30E2" modified="2022-05-25" version="1" fragment="single">NIKSERRQHQPVTKMTEKKAKGPTVTPQLARMRGQWVQETTEVTIKAPNNMLGVVVGPGGSTIKEIQEKYKKGSKDQPLRVVGLDKGLVHDAADHIKALVQKAVTTTVTITAPNNMLGVVVGPGGSTIKEIQEKYKVRVFVPQKGSKDQPLRVEGPDKGLVHDAADHIKALAQKAVTTTVTITAPNNMLGVVVGPGGSTIKEIQEKYKVRVFVPQKGSKDQPLRVEGPDKGLVHDAADHIKALVQKAVTTTVTITAPNNMLGVVVGPGGSTIKKIQEKYKVWVFVPQKGSKDQPLRVEGLDKGLVQDAAVHIESLMAYEKERRRLSTPVSETVFIPKAHHGLIIGRQGQNIRYLSLTRRITIVLPPKNVISDEVTVTGLPDQVDQGVRDLVNLVKSSTHICYNSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLT1</accession>
    <name>A0A8J5MLT1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G023303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039326">
        <property type="protein sequence ID" value="KAG7156218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLT1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="639" mass="69208" checksum="47557D29760CFA90" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MM13</accession>
    <name>A0A8J5MM13_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450 6a18-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Cyp6a18-L1</name>
        <name evidence="13" type="ORF">Hamer_G027029</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039911">
        <property type="protein sequence ID" value="KAG7156142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MM13"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7156142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="378" mass="43783" checksum="A41BDA3656A314CC" modified="2022-05-25" version="1">MEASTWTVGLAVVLLFIVYCWRKFSYWSSRGVPSIPVFRNFYIYLHMIFKRTKPFWYFLNETYHENEGNNFVGAYEIFKPSLIVRDPGLVKRIMIQDFDHFSERRTFGNSKKDECLREMLFLINGSHWKGVRSIMSPTFTSGRMRQMYHLVEEKADALIERLQRHCQEKSFVKTKTIYARYVMDVIGTCAFGIKCNSINNEEEEFCKKASELNAISARGTLRGIALLTLPNSVLNAIGISFTTPPFLFFQRVVEETIKNREMGVKRGDFLDLLLEQREEQSNSNTKTPKYPIKDSTIVAQSVLFLIVGHETTAGTMAFVSYYLARNPHLQHRLRQELRDIVEEHGTLTYQTIMEAPFLDAIFSAALPRESRAPFGSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MN41</accession>
    <name>A0A8J5MN41_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine protease inhibitor 88Ea-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Spn88Ea-L8</name>
        <name evidence="6" type="ORF">Hamer_G019168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037402">
        <property type="protein sequence ID" value="KAG7157536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MN41"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19594">
        <property type="entry name" value="serpin_crustaceans_chelicerates_insects"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF278">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR 88EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="5">
        <location>
            <begin position="80"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="5">
        <location>
            <begin position="455"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7157536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="829" mass="91967" checksum="AC75B8CC8DF9FDA6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MP11</accession>
    <name>A0A8J5MP11_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Lysophospholipase D GDPD1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GDPD1-L</name>
        <name evidence="14" type="ORF">Hamer_G008981</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53184"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71464"/>
            <dbReference type="ChEBI" id="CHEBI:137009"/>
            <dbReference type="ChEBI" id="CHEBI:137017"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:53185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41143"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
            <dbReference type="ChEBI" id="CHEBI:77580"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:41144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(9Z-octadecenoyl) ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71466"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:85222"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:56461"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45544"/>
            <dbReference type="ChEBI" id="CHEBI:2700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:85223"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:45545"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoylethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53168"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71464"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:85217"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:53169"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MP11"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052271">
        <property type="entry name" value="GDPD-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42758">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42758:SF2">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GP-PDE" evidence="13">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7158330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="158" mass="18053" checksum="85CC58E9D24A48B5" modified="2022-05-25" version="1">MLELDCQLTRDGQVVVSHDSVLDIRTELKGAISEYNYAELPPIKDQIPIDFMPGLIFSSINEDRRIPLLEETFHHFPNTPINIDIKIDSNELISKVSDLVKKYQREHITVWGNMKDVVTQKCYKEVNCKITPPGHLLAEPALSRQGRRLSACLKQLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQ61</accession>
    <name>A0A8J5MQ61_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tyrosine-protein kinase yes-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yes-L10</name>
        <name evidence="8" type="ORF">Hamer_G022231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032883">
        <property type="protein sequence ID" value="KAG7159681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQ61"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7159681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="284" mass="31975" checksum="D14958CFC61A81F3" modified="2022-05-25" version="1">MEAVRDLYWDEVENLVQNNICVLGTGTHGTAYLVRWGGETAVLKVAHKSHAVRSFWQETEALLRLDGAGGAPRVTGFCNDPPAILQEFKGLVTLENILNQLHDERETRYNLIEVGLRIGEQLEDFHRSGLIHNDLKRDNILVNGSPSNPQVSIIDVGLACYSHENIRCNSDPNKFPWMAPEVCLGQESTRASDTYSYGVLLSKLAVKAPGYHPDVFALALQATEYNPYHRISLPSLLHRLRGLLRHNQVNVTQHPIQVVMPQPRFILPPMPRPTQYLVSLYQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQB8</accession>
    <name>A0A8J5MQB8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G027910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031944">
        <property type="protein sequence ID" value="KAG7159846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQB8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035177394" evidence="3">
        <location>
            <begin position="21"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7159846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="300" mass="32269" checksum="1A12A9C42C51BCBB" modified="2022-05-25" version="1">MNTTLLVMVVVMNNTDQVGGVNETQHGARLVVMNTTPAISGGGNEHYTGQDGGGNEHNTDHNDGGGNEHNTGQVGGGNEHNTDHNDGGGNEHNTGQFGGGNEHNIGQVGGANEQNTGQVGGDNEHNTPRIVVVMNTTLTRLVVLMNTTRARLVVVMNTTLAIMMVVEMITTLARMVVVMNTTLARMVVVMKSTLARMVVVMNTTLARTVVVMNTTLARTVVVMNTTPTIMIMVVMNTTLARKVVVINTILTIMMVVVMNTPLTRLMLVMKTTSAMMVLVMNTTLAKMVVVMNTTLPGWWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQG6</accession>
    <name>A0A8J5MQG6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Hexc-L6</name>
        <name evidence="14" type="ORF">Hamer_G017407</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7159965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQG6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="13">
        <location>
            <begin position="137"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="12">
        <location>
            <begin position="288"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="637"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7159965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="652" mass="72956" checksum="550FB8C7EDFD311E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQJ1</accession>
    <name>A0A8J5MQJ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7160024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQJ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="65" mass="7809" checksum="22AEBDFDD319436D" modified="2022-05-25" version="1">MYRTCWWNEICKEEFQMEFRCRCPRWSSCRSPGKYYNAYCSVMASGYIWTQPRLPGTNNSKYGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRK5</accession>
    <name>A0A8J5MRK5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030867">
        <property type="protein sequence ID" value="KAG7160747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRK5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="88" mass="10428" checksum="797EEA76FA42E6EC" modified="2022-05-25" version="1">MTEGYTSPPTPENRRLLSTTNTRCLRLHHHHHQMTGEGQASPSTPDDRRLHHHQHQMTVAKHHHHHQKQKAKHHHQHQMTEGYITNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSK3</accession>
    <name>A0A8J5MSK3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028009">
        <property type="protein sequence ID" value="KAG7162233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSK3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="209" mass="22182" checksum="02F8170EEA7F9F95" modified="2022-05-25" version="1">MSFRRHYGTGSYSSSLLTSPLTSNYGSRGLGGYNSSYSTPHSYTPSYGNYGSYGSKNSSLSRSASLPRDTRERSVPRYSSSYSRGTSPARSSIALPSRLEVDLSDSSSSSGDTPLHSINRHHSFSSGGRSGVSSVTPRSYSRDYGTHYSTTKGFIRSSRSKSVGSTGSVSSLSSGYGSASGVSVPSASCPSFTYQGGHHYSVAYEYSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUE0</accession>
    <name>A0A8J5MUE0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CENPB DNA-binding domain containing protein 1-like 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G005182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUE0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="93" mass="10510" checksum="05C1CED93C6FADF9" modified="2022-05-25" version="1">MCSNVKRGELTTDITRALDLGESTLRTIHDSAEKIKESAKSGTLVSAFKPSYSRSLIKEQMLITWIKHQTDKNVPISMPVKQAKVWSILYFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWW3</accession>
    <name>A0A8J5MWW3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pro-resilin-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G011158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWW3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035220666" evidence="4">
        <location>
            <begin position="17"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7166327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="123" mass="13696" checksum="4FEEA0256231E9B8" modified="2022-05-25" version="1">MDFVLLLLAVVAVAAADKLPIGYGAPEDSSEEHEPAKYDFEWSVKDDESDNDFGHQESRDGDHTQGSYYAHLPDGRLQTVTYYVEGDSGYIADVKYDGEAHYPESDEYKPPKSQYGAPDSHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXH2</accession>
    <name>A0A8J5MXH2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021063">
        <property type="protein sequence ID" value="KAG7168050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXH2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="68" mass="7623" checksum="4B4EE5475A3C5693" modified="2022-05-25" version="1">MDLAKMDTNCREAVPQKERLAVCRRQTGQDFSRRNPRLVGGCRPPAAVSLTGRVNSYIKIHLRNVDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXH7</accession>
    <name>A0A8J5MXH7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020923">
        <property type="protein sequence ID" value="KAG7168065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXH7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="184" mass="20820" checksum="3F182ED1CF167DC1" modified="2022-05-25" version="1">MTFWDNGDSSWDNGDSFWDNGDSSWDNGDSSWDNGDSSWDNGDSSWDNGDSFWDNGDSFWDNGDSSWDNGDSFWDNGDSFWDNGGSWDNGDSFWDNGDSFWDNGDSFWDNGDSSSWTYIKVHIEKLDNRNVYRHSREIRPGTIACRLCSAEVPGAFLSESCGEESATARQAVGQERQQPDDKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY03</accession>
    <name>A0A8J5MY03_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G013050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY03"/>
    <dbReference type="OrthoDB" id="6360372at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7167572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="307" mass="33289" checksum="7D1C797954BDFDC7" modified="2022-05-25" version="1">MVKMQAVQSALAIRRQRSRREDQRRAKERRESRASLSTPRPSVVSLDGRVYFNEERENKKLLGQVTMFHVGSVFIVIGLMLTITSLVPGYVKSTTPERRSNLLGTGCFFVFLGGVLTTISRFVSNNEEKELNKYIKGRLARSKSGHRLVRDAESGLPTPTRERHKPQQNGVVPLSPAKAAGSGTKGGHVKKASLASDTKDEPPSPTLSTPDSEAECSSPGILDDNGVPVPASASMEPVLSRILEEDENDAEVDTATTEPNDTTPESSLTPTSPLETQGLLERHLSTPRKGSKSSSKSSSKSSRHSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N115</accession>
    <name>A0A8J5N115_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">eIF-2-alpha kinase activator GCN1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Gcn1-L1</name>
        <name evidence="7" type="ORF">Hamer_G013533</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000090">
        <property type="entry name" value="eIF-2-alpha kinase activator GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000096">
        <property type="entry name" value="eIF-2-alpha kinase activator gcn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000162">
        <property type="entry name" value="GCN1, eIF2 alpha kinase activator homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1298"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1472"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1549"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1591"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1711"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1939"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="2198"/>
            <end position="2236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="737"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7170707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2624" mass="286365" checksum="6C908FB7AD3869EC" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2W1</accession>
    <name>A0A8J5N2W1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G028801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011591">
        <property type="protein sequence ID" value="KAG7172161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2W1"/>
    <dbReference type="OrthoDB" id="10421198at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="347" mass="38571" checksum="C18962CE7724A7BB" modified="2022-05-25" version="1">MDVIGVRVVVYVLVSLSFMAQLGSTLVTLCTLETNSITLERDERALFKADEDIVEIYMRSLSTGLIGRYSINVPQDLATNPFMTGNDYEWYEMTYTANDTHLIVIIRGNNTLYIEEKWTSNSTNEAPSLEFTFTGIAKLGTFCFDQPLSVKLLHVLDNVDYSGKPYRPTPPSENYHYSSYSGGHIIFIPVGAIIFFISICCRCCYRRKKILQPVRSIDVVMNVPDADTTPSGCDRTQGDNDLPPSYTDIQTEIPPPPPYSEIEKQNIPSSNTSPLEEILIDPAEDVTDHTNTGVSTENTPTGLDSPVDSTNVDSTNTNSVSSSNMLARVFSSRPSAQFAFKPLKEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5Q1</accession>
    <name>A0A8J5N5Q1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009009">
        <property type="protein sequence ID" value="KAG7173767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5Q1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="80" mass="8765" checksum="DE4AD36DDE805C56" modified="2022-05-25" version="1">MAKQAQEEYQRREECMSHILEHVVSQQEPSHHSTTTTNGATSSSAPWQTKFPFGAAPDLHLSSSASLLEFDACSTSLRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6N9</accession>
    <name>A0A8J5N6N9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ATP synthase subunit a-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ATPase6-L2</name>
        <name evidence="16" type="ORF">Hamer_G003075</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6N9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00310">
        <property type="entry name" value="ATP-synt_Fo_a_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="entry name" value="ATP synthase, F0 complex, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="F1F0 ATP synthase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="FLYWCH-type" evidence="15">
        <location>
            <begin position="74"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7174177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="127" mass="14091" checksum="35E7DDEB14397BBB" modified="2022-05-25" version="1" fragment="single">TLRNIIRPGTLAVRLVANIIAGHLLLTFLGNIGPSLSLTLVSFLMLAQILLLILESAVALIQSTRGHITLSWSFVQSERGKTKLIYGVYIYVKQKELVNGVISYECERRRHNNFKAKVKVCGNEVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N711</accession>
    <name>A0A8J5N711_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N711"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="65" mass="7616" checksum="7A3ACBF6B4EA0ED2" modified="2022-05-25" version="1">MGRHTERTAILRVLRMIHELPFDIDMSAHWTGYNSLLPSYTPVHTHNVLRCRAQRYGRFYDVGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7H0</accession>
    <name>A0A8J5N7H0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7H0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035171546" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="49" mass="5941" checksum="395E3AFE9D71BB94" modified="2022-05-25" version="1">MWRWCGDMWCGDMWGWYMWGWCGDMWGLCGDIDGGWCGDMWGWCDDMWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7P6</accession>
    <name>A0A8J5N7P6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Homeodomain-like domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7P6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="126" mass="14155" checksum="3F422D70AD418A4B" modified="2022-05-25" version="1" fragment="single">FVPLFRRDNTHDLATLISRFSEHVGAVCKLLSRGLVVFLRFFLCLCLNISVMGSGKELGGDTIVAIITLYKEGCKCKDIATRVGIGVRQVQKWIKKFRDGGEKLARCIPQRLEKVIKLRGKSLGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N814</accession>
    <name>A0A8J5N814_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Charged multivesicular body protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CHMP6-L</name>
        <name evidence="13" type="ORF">Hamer_G022074</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005701">
        <property type="protein sequence ID" value="KAG7175535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N814"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000057">
        <property type="entry name" value="Cyclin N-terminal domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 10" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="240"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="711"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="733"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7175535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="750" mass="85103" checksum="B469C5E030E25726" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8A6</accession>
    <name>A0A8J5N8A6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein FAM193A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Fam193a-L</name>
        <name evidence="6" type="ORF">Hamer_G016435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM193 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029717">
        <property type="entry name" value="FAM193"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031802">
        <property type="entry name" value="FAM193_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15109">
        <property type="entry name" value="AGAP004327-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15109:SF4">
        <property type="entry name" value="FAM193 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15914">
        <property type="entry name" value="FAM193_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM193 C-terminal" evidence="5">
        <location>
            <begin position="1959"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="770"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="965"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="1162"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="1522"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="1601"/>
        </location>
    </feature>
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        <location>
            <begin position="1737"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="1799"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="1927"/>
            <end position="1950"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="102"/>
            <end position="113"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <end position="1350"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <end position="1418"/>
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            <begin position="1459"/>
            <end position="1485"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1494"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1511"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
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            <begin position="1556"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
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            <end position="1601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <end position="1772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1820"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1838"/>
            <end position="1850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1858"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1870"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1927"/>
            <end position="1937"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1938"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7174533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2018" mass="220450" checksum="E8D43BA82A93A712" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N980</accession>
    <name>A0A8J5N980_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Gamma-aminobutyric acid receptor subunit beta-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Gabrb-L8</name>
        <name evidence="13" type="ORF">Hamer_G009087</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N980"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051360">
        <property type="entry name" value="Neuronal_Pentraxin_Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277:SF125">
        <property type="entry name" value="B6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277">
        <property type="entry name" value="PENTRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="12">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="11">
        <location>
            <begin position="129"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7176300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="788" mass="89540" checksum="D8A1EA79C8456606" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9U5</accession>
    <name>A0A8J5N9U5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase</fullName>
            <ecNumber evidence="3">3.2.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Ect4-L</name>
        <name evidence="14" type="ORF">Hamer_G009023</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16301"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="EC" id="3.2.2.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16302"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.6" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9U5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044297">
        <property type="term" value="C:cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061809">
        <property type="term" value="F:NAD+ nucleosidase activity, cyclic ADP-ribose generating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034128">
        <property type="term" value="P:negative regulation of MyD88-independent toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048678">
        <property type="term" value="P:response to axon injury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09501">
        <property type="entry name" value="SAM_SARM1-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24153">
        <property type="entry name" value="SARM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000043">
        <property type="entry name" value="Sterile alpha and TIR motif-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000012">
        <property type="entry name" value="Sterile alpha and TIR motif-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039184">
        <property type="entry name" value="SARM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998:SF1">
        <property type="entry name" value="NAD(+) HYDROLASE SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998">
        <property type="entry name" value="SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="688"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="835"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="994"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1015"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7176245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1035" mass="114149" checksum="52FA84C3E06C9DE7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA78</accession>
    <name>A0A8J5NA78_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative golgin subfamily A member 6-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Golg16-L5</name>
        <name evidence="3" type="ORF">Hamer_G009777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA78"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="301"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="435" mass="49686" checksum="82C4A70D4845B65F" modified="2022-05-25" version="1">MYLENGASRCREKGEKLGNKNFTPNFIHRLEHSPTNFPSPYLLSAQTTSPLTPVCGLVRAPPSITLNLDGMVNCSSNSQDMELQSLRYQVQEIHNKLNGDIKGNSEYQQSTEYALQQLKTTYNGLRNSASASEQEFLQKLEDIQEKYRLLNERHCTASDQLTRLKDYLRDLPTLSEHQNLQQEILQKCAQVSLLSSKVDYLSEQMKKLVKKENEQAATIHTLTQQRDDLSLKLDLSENLLKSQRATASEEGHPSKEDLLWTSNQLKKELESAKKLLNYRKQKVESLHKDFLAQDKMYAEKLEAEQEQGEKLKETVWQLERDLEQYKIKEEKMISKLTNAEQKQKKTEERLEMALGQVASQCQMSSVMDSMLSNLHIAVHQAKPLEDSESVTTEGLTTRLKEVRGLIQQLEDCSSENVDQGQLQSDLADSTQPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAB2</accession>
    <name>A0A8J5NAB2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004813">
        <property type="protein sequence ID" value="KAG7175688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAB2"/>
    <dbReference type="OrthoDB" id="6341029at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="172" mass="19444" checksum="9E0779ADF19FF461" modified="2022-05-25" version="1">MPNGEFGDSVDMTCSDDTAVALDEHLRKIHGDSWIMARGIQINPYYGWEDNVKYTIVLGLQCVGEGEVWLVSCRPPITKKPIKNLTTISQCNNPINKRTLFAVINEIIKKPQRTTKGTYHLILCLVDPTCLEHNAPRKNLPLHMFLNDYSIKNLPGVISRGDIIQVKNMVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NC37</accession>
    <name>A0A8J5NC37_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transient receptor potential cation channel subfamily A member 1-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Trpa1-L12</name>
        <name evidence="13" type="ORF">Hamer_G015498</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099604">
        <property type="term" value="F:ligand-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF12">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="739"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="856"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="915"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1029"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="11">
        <location>
            <begin position="240"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="11">
        <location>
            <begin position="378"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="12">
        <location>
            <begin position="490"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="796"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1251"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1251"/>
            <end position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7176679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1352" mass="154429" checksum="CC2B1136AAFD4D59" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NED1</accession>
    <name>A0A8J5NED1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000095">
        <property type="protein sequence ID" value="KAG7178302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NED1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7178302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="59" mass="6811" checksum="8BC77D22AFFAA541" modified="2022-05-25" version="1">MDEMLHTQHKQQLADISGIYQNILSVCLFDDRIDTETKKNMVQNPVPKETGLFKAYCPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5SZX5</accession>
    <name>A0A8J5SZX5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative 7tm Chemosensory receptor-containing protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Hamer_G014665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5SZX5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051606">
        <property type="term" value="P:detection of stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21421">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21421:SF29">
        <property type="entry name" value="GUSTATORY RECEPTOR 5A FOR TREHALOSE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7171539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="481" mass="54177" checksum="E86FA4FF48744B37" modified="2022-05-25" version="1">MAKDIRLILRVARVCGSWPLTETGDRKTAKITPRKKEGKIVRIREDAWGEEARKKEEEEMEDKTIPLITSQKLASLPWFGSCIVPWTCGILMLMRARKAAEFLDSWRAVEYHLNRHMLCLAEAKLRVCILIAYVFMALASFGVLCYQFIIDEESSVYFGNLVSPPWSWPLNVLQHVFVPFTWAGYLVPEALVMVASHHIATYYRSLNTFLGEHFQKWVQARRSSLLAYRSDMTTKNSFATQNNTGIYSHTDHETPPFPNSLSIASVSTVTSACDCHQQAQDSQREYLNKLRETWSLYEDVGDFLGKFNALFSPIILINLASFLIMTCTLLIPVLKTDDALSHIGYLGNAAFYVIRLPALILVQACVHNQASHTQVVVGRGHANLVMTGFYLRDLDAILAQLSADEGQGVSAWGFFYVTRESLLTFLSIMASYVEEAEDDEGDEEAEDDEGDKEAESDEGDEEAEDDEGDEEAEDDEGDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T421</accession>
    <name>A0A8J5T421_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TfIIB-L</name>
        <name evidence="15" type="ORF">Hamer_G022185</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010676">
        <property type="protein sequence ID" value="KAG7172530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T421"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20552">
        <property type="entry name" value="CYCLIN_TFIIB_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000008">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000019">
        <property type="entry name" value="transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000007">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="14">
        <location>
            <begin position="4"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7172530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="309" mass="33767" checksum="8D75886CA38209FD" modified="2022-05-25" version="1" fragment="single">GRFNEVSCPYHPEAHLIEDYRAGDQICSECGLVVGDRVIDVGSEWRTFSNEKANNDPSRVGGPENPLLNGSDLSTIIGPGTGSASFDGFGGSKYQNRRSMSSSDRALINAFREISNMADKINLPKTIVERANVLFKQVHDGKNLKGRSNDAIASASLYIACRQEGVPRTFKEICAVSKISKKEIGRCFKLILKALETQVDLITTGDFMSRFCSNLGLPTSAQKAATHIARKAVDLDIVPGRSPISVAAAAIYMASQASEDKRTQKEIGDIAGVADVTIRQSYKLMYPHAKELFPEDFKFCTPIEMLPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T9S7</accession>
    <name>A0A8J5T9S7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Vesicle-trafficking protein SEC22b-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SEC22B-L2</name>
        <name evidence="18" type="ORF">Hamer_G018586</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus</location>
            <location evidence="13">cis-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012106">
        <property type="protein sequence ID" value="KAG7171467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T9S7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="16">
        <location>
            <begin position="6"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="17">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7171467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="195" mass="22429" checksum="1157DD04BCA3F009" modified="2022-05-25" version="1">MVLMVMIARVSDGLPLAASLQDDEQSGRSLVDYQNQAKMLFKKLTVNSPNRCTIETGPYVFHKKTAFTFLEEMSSEFTLQHGPKVPQATRPYSCIEFDTYIQKLRRQYSDQRGRRHLHQLREDLNDVQRIMMDNIDDVLQRGATLSDLETKATGLSIMSKKYHKDAQYLNMRSTFAKIAAGAVVTLVFIVYFFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TGR4</accession>
    <name>A0A8J5TGR4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G016370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TGR4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="92" mass="9085" checksum="AA1244D6ADF2BF41" modified="2022-05-25" version="1">MGIRREKEGEGRSGVGGCGSVCCEDAVRVVVWCRGGCGSCGGFVWCGGCGSVCGGFVVQFGSCGGFVWCGGVVGSSWCGGVVWCGGVVGWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5THL7</accession>
    <name>A0A8J5THL7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5THL7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="178" mass="19906" checksum="E18F7B0DA181B667" modified="2022-05-25" version="1">MVDDLTPSTSPPHNREVLSVCEFGKKYNVKNAADRIVEAWRKINVATVLHAGKPLFNNSEANGAEQTEASRERQSVAATLMDMVEAAQSVPAPGFSDVQVEDLQEIIGHHQQQLTIKEMLEEDEEQEEQQPTQEDDVKPGEPTTSQLTQVLTSIALFSEQLQKYDTRPHHSEPYLPCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIX8</accession>
    <name>A0A8J5TIX8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIX8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="493" mass="55438" checksum="15DF1735E85D90C6" modified="2022-05-25" version="1">MVPIIIIGVRVRVTYREATVMTGRVPGNYGLVDNSASCHYTHATAALYLQTRASREERLARQNNNNTHDVKNRNPKNSEICWGHSAQPQKTGRSITPYGDTEETVVERHQPTGPQGSRESLSHHVFQLSGNFLAFLQTIYPQEPHQPSVPQELPSSLQEFQQDISAEHSQQSCNLQERQHASILQEPWQRNSLHVTQQRINSHQSYQLSGERLHLPTCLQHPRVPAAQAPTRVPAVQAPTRVPAAQAPTRVPAVQAPTRVPAAQAPTRVPAVQAPTRVPAVQAPTRVPAVQAPTRVPAVQAPTQQSRLPHVSQQSRLPHVSQQSRLPQQLSLPYVSQQLNNPVLSQLSSKFSSWSERCWKTDDWSVNSWKSLEWVKSGNWKPEWLDDKDLGDLLKKTKDWGSEWLESEWQRAKDLDMRRVPIGDWFGLSDEIKDGIEMKPNIYPRVQRWLVQYGTRGAHFNRILVAVDHCSTLEAVVSVEGGGRTAAGGRYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKD7</accession>
    <name>A0A8J5TKD7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphomevalonate kinase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PMVK-L</name>
        <name evidence="7" type="ORF">Hamer_G018130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008733">
        <property type="protein sequence ID" value="KAG7173852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKD7"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13101">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13101:SF1">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7173852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="95" mass="10978" checksum="68735DC94A3A3AFD" modified="2022-05-25" version="1">MRRQSDLSWFKQHYGECLYTVRITASEEVRKQRGWVFTPGIDDAESECDLDNMTDWDQEVDNSNDPGKVDELLHHLTTLCSQRLSSATRSTGKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKZ9</accession>
    <name>A0A8J5TKZ9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKZ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="531" mass="59360" checksum="FEE0C4BE8EB3DC30" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLB6</accession>
    <name>A0A8J5TLB6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLB6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="243" mass="27112" checksum="925E2E71BB641927" modified="2022-05-25" version="1">MESTRSKTEVWLIGQHITEITGAQLPSRGDVLRLFFHGHNEHKKTVNDSASEVAASVISFWNKARIPTITEKSIGRKVVDLFLMWKGLKKNCTRTTDTQRKKEETFCDELEDLFDVAHPKAMQLLTIKEDRAFLAAQREKGRRGVMAGVDKKIACSIKRREESKSKQSLQQNQASSALEYDELGSSSETESQSSSSSSTSSLAISPVVSSSNRKRATLKVITPELSSTLDRTGISHRSVLRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLH3</accession>
    <name>A0A8J5TLH3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cuticle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLH3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="67" mass="7677" checksum="0A32880274BB0B90" modified="2022-05-25" version="1">MGKFFYPDGTQEDLRFTADEFGYQPQSALLPTPHPLPAHALEQLRIAEEQRAAGITFDQRGFRVNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLR6</accession>
    <name>A0A8J5TLR6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G030721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000984">
        <property type="protein sequence ID" value="KAG7177931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLR6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="138" mass="16828" checksum="3F03C17E88E0C278" modified="2022-05-25" version="1" fragment="single">MFDYIKAFEMKLGVFKRDVDSERFRYFPNLKKYINDLTKDDKTDCQCLQKLFVNIIESTVEQFSTRFARFRELEETAKFIKFPDSIKLDELNLQKFSWIDMDDFEMQLIEFQTSSIWRQKFVELRADLESIEKDQLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TNK0</accession>
    <name>A0A8J5TNK0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nesprin-1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Syne1-L2</name>
        <name evidence="7" type="ORF">Hamer_G016954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7175998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TNK0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052403">
        <property type="entry name" value="LINC-complex_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535">
        <property type="entry name" value="MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535:SF1">
        <property type="entry name" value="NESPRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="356"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7175998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="534" mass="61647" checksum="7B0690A69745FE0C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TNP9</accession>
    <name>A0A8J5TNP9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP-binding protein GEM-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GEM-L</name>
        <name evidence="4" type="ORF">Hamer_G023847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004205">
        <property type="protein sequence ID" value="KAG7176103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TNP9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF6">
        <property type="entry name" value="RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7176103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="152" mass="16746" checksum="D2AD61F47E9B3FC0" modified="2022-05-25" version="1" fragment="single">REGHADGWVVVYSISDRESFQEASTALGKIWSLGHVTHRAVILVANKTDLERTRVVPITEGRTLAVTYECKFIEVSAGFDHNVDELLVGILTQIRLKQQAQQQTEGETGPASTAAGSDTSPTSTTSKLRHKNSFRVKGILNKLLNKDRKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TUP6</accession>
    <name>A0A8J5TUP6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G008161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TUP6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="171" mass="19510" checksum="AD7EB627905A9FBE" modified="2022-05-25" version="1">MDRDVLRHGRGLICTLPGQQMETIEEIVLGDNVNTFTCHLWESLMGSLNYTAEVIPLSWLRCRCLTLEGNHIFLLDIRDHCQECHVIYNGCFGNGRNWGSSKPRRDGGIPVLSWTPRTEQHQWSHVFTAQMERWGRPEVNLFAARSNAQLPQYITRSLPTPTGGPDAFTMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J7P9</accession>
    <name>A0A8J5J7P9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046438">
        <property type="protein sequence ID" value="KAG7153585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J7P9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="224" mass="26008" checksum="8F9181E9E621424A" modified="2022-05-25" version="1" fragment="single">MAQLQKQVIQTEPNNGPVVTYSEALKSVKKPQTKPKELPRETSPQVARSQVARSQVVTKHRKPCHPWEAEDRPEGWTGLWWWNAPMPKHLWALLNTKKQTEDRAGKAKPKPVNPLPPVKNNETPDEWLARWWRNDNMPTRRARPRETRSQVARSQVARSQVARSQVARSQVARSQVARSQVVTKHPKPCHPWEAEDRPEGWTGLWWWNAPMPKHLWALLPTEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J946</accession>
    <name>A0A8J5J946_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-ketoglutarate-dependent dioxygenase alkB 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Alkbh6-L</name>
        <name evidence="9" type="ORF">Hamer_G020494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045000">
        <property type="protein sequence ID" value="KAG7154185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J946"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="42"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7154185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="182" mass="20954" checksum="DFCBB40DE7E5C7B1" modified="2022-05-25" version="1">MTSFKEYRVYNLLLFIKLFAFSQWLQEQMDKITALGAFGDKKANHVLVNEYLPGQGIMPHVDGPMFYPTITTINVGSHSVLEFYTPLNSNEEMENNQNLSMRHIGSLLLEPRSLLIIQEDLYTTYLHGISQVTQDTVSQDMFNFEECKPKLGEVLTRETRISLTIRHVPKVLKTKLMLGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDI3</accession>
    <name>A0A8J5JDI3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G006152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDI3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="37777" checksum="1C8F82835B04B9AB" modified="2022-05-25" version="1" fragment="single">ASKVKLFNAVSSQLLGDSVDVSLREDHGEASQVNVVESRSVTDELRLLERSWTRSPPNGASKFSTYPCSYCGKPGHKAEVCWTRLQLNTGKPAMIVTEETNTSPVGVMADLSKADSMPIELVFTKGEARESAVSILASRDFDLSRRVLRRTQTLVPFVPFCHKARHYFERLGLSPNSHQESVVAARKTDKYVVLGSLWGQGVAPLVLVRVKSSCFSGIANVACVHELPVAGVDLILGNDLAGGQMGNVTPPPVLREKPESTAELQQLEDDMPGVSPLCAVTRSMSMTNDHNVTPVVDDSLSLEGLFANPIASQDISSAVNAVTGRVALIAAQEQDDSLRLLFDSGPTTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFU0</accession>
    <name>A0A8J5JFU0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oplophorus-luciferin 2-monooxygenase non-catalytic subunit-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Lucb-L6</name>
        <name evidence="5" type="ORF">Hamer_G012031</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFU0"/>
    <dbReference type="OrthoDB" id="6374966at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052286">
        <property type="entry name" value="Wnt_signaling_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24364">
        <property type="entry name" value="LP06937P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24364:SF18">
        <property type="entry name" value="LP06937P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035270123" evidence="4">
        <location>
            <begin position="24"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7155894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="348" mass="38995" checksum="AD574C2B079A5002" modified="2022-05-25" version="1">MKGSHLYCLLFTILGVVQYGVVASGSKSSVEDQQDVLCPVPEDIFPCVCGVNDNNTLDIDCSKVVYEDELANVFRSYFPNPNFRRFTIKFNYYLQTLRDGALGNTTYTEFFFTESVLEVVEKNALSGSFHTATYLNFYSTKLQSFPFDDISSFTKLVTLDLRFNYFHEFPNISSVTLKTLALGGNSFDHLPTEAFVNTPSVSSINVYLGKLWNISSGTFSGLPYLESVDLSFNFLKHIPEAAVEVTTPTYINLNYNMISSVEVDAFLGVTGGSIDLHSNQLKEIQEAVWRPLLQYKVQLDLSKNPLECGCELAWLVLSDTFLHQVNENTTCADGRLVVDLDPADYEPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JG40</accession>
    <name>A0A8J5JG40_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transmembrane GTPase Marf-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Marf-L</name>
        <name evidence="15" type="ORF">Hamer_G019181</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037402">
        <property type="protein sequence ID" value="KAG7157547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JG40"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09912">
        <property type="entry name" value="DLP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000214">
        <property type="entry name" value="Mitofusin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006884">
        <property type="entry name" value="Fzo/mitofusin_HR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF3">
        <property type="entry name" value="TRANSMEMBRANE GTPASE MARF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04799">
        <property type="entry name" value="Fzo_mitofusin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111479">
        <property type="entry name" value="Fzo-like conserved region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="124"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="705"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7157547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="755" mass="84973" checksum="B7EFD3E62C542DB7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGP9</accession>
    <name>A0A8J5JGP9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGP9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="524" mass="58893" checksum="50B9027F64B49751" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHT3</accession>
    <name>A0A8J5JHT3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Tigger transposable element-derived protein 7-like 79</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Putative Tigger transposable element-derived protein 7-like 80</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TIGD7-L80</name>
        <name evidence="4" type="synonym">TIGD7-L79</name>
        <name evidence="4" type="ORF">Hamer_G027373</name>
        <name evidence="3" type="ORF">Hamer_G028379</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034732">
        <property type="protein sequence ID" value="KAG7158537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010026139">
        <property type="protein sequence ID" value="KAG7163877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHT3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7163877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="106" mass="12028" checksum="9BD5ACB7A7A4B499" modified="2022-05-25" version="1">MSSKGSNTLKRKYVTISVNQKLELIRKLEAGASVARVCDEYGVKKQTVIEKNNSHELRKKLLQEKNLTLDKVLDIARALEAANSQAQTIEDRSHNDSQVNSFNYHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLD3</accession>
    <name>A0A8J5JLD3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate receptor-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Glrk-L5</name>
        <name evidence="16" type="ORF">Hamer_G001773</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLD3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="32"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7160497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="300" mass="32776" checksum="E9562B598A415F59" modified="2022-05-25" version="1">MTGFKNGAFLEVSAVHWPPHIVVEEAVGGGGELTVGGPMGDVLTTLADSLNFTYKIVQPGDRAWGAKLPNGTWSGMVGQVSRQEVDIALGPFGISEARFKVVDYTRAFYYDDRSILARKGLPEVDPWGFLYPFTPLVWAALVTALLVACLAVVVLGSRPKTWTHLSWASQLLLLHFRIVLHQDLSMKTSSGRERLVVGGWMVVAMMLMWSYRGTLISLLAVRHVPQPLQSIRDVVQDSSVTVIMKPDTIRHVIIGTTLSADLLIANLFAKQGTLVLLAAGLLLAFASFCLELFLANDVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPK8</accession>
    <name>A0A8J5JPK8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pupal cuticle protein Edg-84A-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Edg84A-L3</name>
        <name evidence="5" type="ORF">Hamer_G021026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028818">
        <property type="protein sequence ID" value="KAG7161686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPK8"/>
    <dbReference type="OrthoDB" id="6630425at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035206324" evidence="4">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7161686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="138" mass="15512" checksum="B40FEFADD551140A" modified="2022-05-25" version="1">MFTKAALVVVLVGVVLAAPDNLYGAPHQQYREEPKPYNFNYGVKDDYAGTDFSQNEESDGNTVQGSYTVQLPDGRKQTVTYVADDYGGYRAEVEYYGEAQYPHEYGPPITFKPQAYGQPSYQPPQPSYQPSYQPPTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQL5</accession>
    <name>A0A8J5JQL5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate receptor-like 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Glrk-L22</name>
        <name evidence="16" type="ORF">Hamer_G007814</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQL5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="84"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7162300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="331" mass="37860" checksum="9863D64A26B8EB03" modified="2022-05-25" version="1" fragment="single">SRYELREPLDREWGSAVGDGNWTGIVGTLQHQQADFSLDLTLTESRSRVMDYSRVYYQDPMIIVSPKPTPLPRHLALTRPFEGELWLVVTVCTFVLGIILWLLQKMWSWVSGDRGASLVSTLFDSWGMLLMKPITEIPTNTNGRVLVGWWLLTCVIITTAYRSSFIAHLSVQSKYPPINNFQDLLNRDGWSWGSKALEGTTYVYFNQSSDPDIQKIFKKIEIYPMEDGLKRVLAGGFSLIVVKMYAKVHAGEIFFDQYGNSPYQLARTEYPIFGGNVWGFRQGAPFTSQISKMKLRLIEAGLLNLWLDDIIKTKNELRNSERDKDELPLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQP2</accession>
    <name>A0A8J5JQP2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G008131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQP2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="77" mass="8484" checksum="9B3A6867F1E7ECF9" modified="2022-05-25" version="1" fragment="single">GSEEAGGGGGVWQPCAAHHNTAPPSPLTGPTWRLTIIYTCILDSKNIPRWEMECYHYRGTITEPRFVTSSQHSGKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQY0</accession>
    <name>A0A8J5JQY0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027477">
        <property type="protein sequence ID" value="KAG7162642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQY0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="47" mass="5662" checksum="8AB381796040E0AA" modified="2022-05-25" version="1">MEHNSREDNKVDNRRGRTTEDNRGDNRTTAYGGDCMFIFESVCWWYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRL7</accession>
    <name>A0A8J5JRL7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative extensin-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029913">
        <property type="protein sequence ID" value="KAG7161111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="411"/>
        </location>
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</entry>
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                <person name="Timp W."/>
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                <person name="Romanova D.Y."/>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="78" mass="8554" checksum="E0B8725AE0E42712" modified="2022-05-25" version="1">MYPTPVGSELGGVPSPYSSLERPYSFRSPSAGLLSAVPKWGRGDTTDALYDSYTDDELPLDPYSHYRGCFVVSVFRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTN8</accession>
    <name>A0A8J5JTN8_HOMAM</name>
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            <fullName evidence="5">Crustacyanin-A2 subunit-like 9</fullName>
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        <name evidence="5" type="ORF">Hamer_G031194</name>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
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                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030720">
        <property type="protein sequence ID" value="KAG7160783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTN8"/>
    <dbReference type="OrthoDB" id="6335136at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19436">
        <property type="entry name" value="lipocalin_crustacyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045016716" evidence="2">
        <location>
            <begin position="17"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="4">
        <location>
            <begin position="43"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7160783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="190" mass="21208" checksum="0D9A6626F8C210C7" modified="2022-05-25" version="1">MFRTVIVAALVACVAADGIPSFVTAGKCASVANQDNFDLRRYAGRWYQTHIIENAYQPVTRCINSNYEYSGNDYGFKVTTAGFNPNDEYLKIDFKVYPTKEFPAAHMLIDAPSVFAAPYEVIETDYDTYSCVYSCITTDNYKSEFAFVFSRTPQTSGPAVEKCAAVFNKNGVEFSKFVPVSHTAECVYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUE0</accession>
    <name>A0A8J5JUE0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeobox protein caupolican-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">caup-L</name>
        <name evidence="3" type="ORF">Hamer_G019611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025477">
        <property type="protein sequence ID" value="KAG7164250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUE0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003893">
        <property type="entry name" value="Iroquois_homeo"/>
    </dbReference>
    <dbReference type="SMART" id="SM00548">
        <property type="entry name" value="IRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iroquois-class homeodomain protein" evidence="2">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7164250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="308" mass="30912" checksum="FD0CFDF3A45867B4" modified="2022-05-25" version="1">MMVSNSTCCQDPAGGGSCGLARLLTMTETKVEDSEGQTELKSCEGGVVANSKAVTAAISPAPALHPTISPTPTLHSTNPFTVPKGEKSDCAVSLPSAKPKIWSLADTAACKTPPPTGGVGGAPGSGWLAGGTTFPLPPTIPPTQQQYPHSARFTHLIDGVGTDTPPQTPPNVKGQQGQQGQGAGLLGTGAFLGGSSSGSYVGGSMSVGLSSCSRGSTAPLPAPGVGSASVGDTSLHQRYQGGGSHAPNHNNTATSLPNTAFTPVYKNAQQGGQQVPQQTSQMANQQQMPCQQTQQVQGGPVTAGPYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUT1</accession>
    <name>A0A8J5JUT1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EARP-interacting protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">eipr1-L</name>
        <name evidence="2" type="ORF">Hamer_G023270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026851">
        <property type="protein sequence ID" value="KAG7162851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUT1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040323">
        <property type="entry name" value="EIPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205:SF15">
        <property type="entry name" value="EARP AND GARP COMPLEX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205">
        <property type="entry name" value="WD-REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="291" mass="32229" checksum="11501B54297B2EAC" modified="2022-05-25" version="1" fragment="single">MDDAPVIYGLEDFQARALAAHAAETEKINFLVGTQSLRRVNQVQLIEFDDDTSLVTKQTFEHPAGEVWRIVAAPQSPDLIATVYNNTQDYCGEFGAAIWRLPLEGSSSGVLDDTRTGGEQVEKLCSLDGTCRGDPQIPGSPVHGLGSQAWSVVWAPEYDSRLLGSQVAATHGSNVRAWDVRTMKPSWCVEGAHTQLVSDQRVILSNLPSIASQPFGTMVDQEESSKEEREKSEGTEEGVIQIYDDHEDSVYAVEWSAADFWTFASLSYDGRLVINKVPRSVKYKQFINHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV74</accession>
    <name>A0A8J5JV74_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mo25-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Mo25-L</name>
        <name evidence="2" type="ORF">Hamer_G018278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027102">
        <property type="protein sequence ID" value="KAG7162753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JV74"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000025">
        <property type="entry name" value="Calcium-binding protein 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="336" mass="39516" checksum="AE2BAFDEB45ED0AC" modified="2022-05-25" version="1">MSLFRKSPKSPQEVSKALKDALTALERSDKKAEKAQEDTSKSLTQIKTMLYGTTDSEPQDIVLAQLAHEFYNTNMLLLLILNLHRIDFEGKKDVAQIFNNILRRQIGIRSPTVEYICTKPEILFTLMKGYEHQDIALHCGTMLRECARYEALTRIILNSDDFYNFFKYVEVSTFDIASDAFSTFKELLTKHKMLCAEFLEQNYDRVFSQYENLLNSDNYVTRRQSLKLLGELLLDRHNFSVMKRYISNPDNLKLMMIMLKERSRNIQFEAFHVFKVFVANPDKPRPILEILLRNQDKLVEFLTRFHTDRSEDEQFNDEKAYLIKQIKELKPLPPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW16</accession>
    <name>A0A8J5JW16_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7164952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW16"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="105" mass="11492" checksum="65CFB4A3865023C2" modified="2022-05-25" version="1">MHVPGSNDHVTGSNDVPGSNDHVYPAPTMYLPNDHVYLALTMCTGSNDHVPTTCAPQRYVLVGFLILRNGHHLLGKDSESRDVTLMTSGTTVTRAGDKWEKLTQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXK8</accession>
    <name>A0A8J5JXK8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G011150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXK8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035261349" evidence="3">
        <location>
            <begin position="22"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7166320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="299" mass="33755" checksum="32636C6586A79D9A" modified="2022-05-25" version="1">MKDGGRVLVVALVMAVLCCSAVTPLTPAQRHQLLLRDYYDDLDTPDDTDTQEPRHTETPLGDSLVSSATATTNTTTAVMILDEDLFQQTEDMLGEISDTLSQLWLYINNGSESDLVWQRLPYVWWREVVKNLIQPGDSPCIDTTGTCMNISITLHDIDQQLDTLTNNTDAWCMTNLKQLKENNKNLRSLMNEADDKDFMDGIIKKSFKVLLKKVKDKVNVGVTTAKDKVAETENRKTKAIIIFLSFSFSMVGLIIVRLLVGLYCMGNQHIQSHMTRKDPTGRHNTKVKGEYVFLEDFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXV3</accession>
    <name>A0A8J5JXV3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G013116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024020">
        <property type="protein sequence ID" value="KAG7165616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXV3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="47" mass="5375" checksum="8B6960F358208992" modified="2022-05-25" version="1">MPDYFAYIAGDTSCSISSHFTCYVFRAATVEQSRDILLTLGKWCRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZU7</accession>
    <name>A0A8J5JZU7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Piwi-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">piwi-L2</name>
        <name evidence="10" type="ORF">Hamer_G003628</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the argonaute family. Piwi subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZU7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02845">
        <property type="entry name" value="PAZ_piwi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04658">
        <property type="entry name" value="Piwi_piwi-like_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000003">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23278">
        <property type="entry name" value="Piwi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="PAZ" evidence="8">
        <location>
            <begin position="195"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="9">
        <location>
            <begin position="463"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="737"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7164425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="760" mass="87598" checksum="EBB25CACBF164ECF" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0D2</accession>
    <name>A0A8J5K0D2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G005337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7167026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="121" mass="13636" checksum="488F7F4E9285307E" modified="2022-05-25" version="1">MIILHKLRQFAPAPEHILEIFGWNDAAFLFVLILPTPQKFSSASVSRSLLCEAQAAPQWTAPYCAHPPTPQHHHPLPGPWNCPDTQFHVQQPLPLTLQSLQSLFEAHIQATMAFKQHKDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0Q4</accession>
    <name>A0A8J5K0Q4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleocyemata</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7166046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5K311_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        <name type="common">American lobster</name>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020263">
        <property type="protein sequence ID" value="KAG7168271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K311"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="68" mass="7228" checksum="20972177FE874999" modified="2022-05-25" version="1">MVTVSAQVMVVLVTKEIRHQSSRMEDSLTPVGANQGLSAKLVIPDSDGDSCHPPRSQLTDLEALIPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K388</accession>
    <name>A0A8J5K388_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Pleocyemata</taxon>
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            <taxon>Nephropidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023710">
        <property type="protein sequence ID" value="KAG7165763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K388"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="75" mass="8778" checksum="53688B52BD6771A8" modified="2022-05-25" version="1" fragment="single">RTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDSSSDEQEATSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K576</accession>
    <name>A0A8J5K576_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K576"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="118" mass="12923" checksum="37928931953BE031" modified="2022-05-25" version="1">MQLTTAPAADGIRQCPSSSRIVKCSVVFVFSSPHSPLAMEFQSNLFYGNSSTVDLEPEADVGDDILDPDVTTTSNKCRKTSKSNKTTTRRSDDDEQQYTKISGSAELPWAKEDINNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6C5</accession>
    <name>A0A8J5K6C5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G002418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Decapoda</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6C5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="260" mass="29593" checksum="AB74DDDA11A1E348" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPSEKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANVKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIGRLFVSFKKSSPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVTATRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6L4</accession>
    <name>A0A8J5K6L4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxyisobutyrate dehydrogenase-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Hibadh-L2</name>
        <name evidence="4" type="ORF">Hamer_G018444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7168010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6L4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF84">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="2">
        <location>
            <begin position="75"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="3">
        <location>
            <begin position="160"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7168010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="286" mass="30868" checksum="44D25FCFE6302466" modified="2022-05-25" version="1">MFRCVRACVHLSRCTRVGRRGLHGASQATTVGVVGCGNVGAAVSHNLHRQGFRVVGAYDPDPARYADLPPGVTYGILAGLSKDKVWIDHSTTDSDQTMVYSEEAQKVGAYVLEAPITGGLASLKKGQMVVHLGGDKRVADAMTPLLNASYSKVFYVGEIGTAMMVKVISNMLACVHIIAMGEVLMLGKRAQLDLKTLWQAIRVSAGNSFVWETGAPLVFTGSYDPGFTMALQNKDLQLGYDMARKYESVHDRHPDGHELPPPPEGGGLRTPEEVLVLSPVGWHRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7M0</accession>
    <name>A0A8J5K7M0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G022666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018361">
        <property type="protein sequence ID" value="KAG7169128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7M0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF3">
        <property type="entry name" value="MYCBP-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="189" mass="21710" checksum="8D147925CFE4E0C8" modified="2022-05-25" version="1">MCQLEARHPDVYDQFSRGFHVIRRSNQCWAGLSSDLVIEQTLMRSSKSIGGLTHGSGMTEEMRALWTMSIPITSEYNNAMQEFNDLTYTTSEQHRESTEARMKRDHSDLEKIKEKLSTCMPFSPDPSLRNIITGLVAKEDVNVHEYETVGNEIIEKMVGKPVFGISFKRNDRAKTLARVHHQIFPRPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8P5</accession>
    <name>A0A8J5K8P5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G010458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8P5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="286" mass="32538" checksum="18C9B8AFBA6784F3" modified="2022-05-25" version="1">MMEARLLKLPSGKISNDTAFLMDDDDRMARLRHLMQVKEDLKNEIEKSALEADEWLQILETSSSTELEDLMLSLPSTAPMTIEHQGILKEYCQLSTQLQAYSFHETTAAYMTAEGNLLLKFLRPSFKSQYSTLLILLTKGEKNEGVKKFITAITQYTNALYLRQDQIVTLQKAEFLNKMQVYHNQGCTFLSFMVEVKNEDEEITYEFTLDFYPRDILPYRVKASHIDGATPSLSLADIMQDMAVDMKVVPFPQVLYLTFGGQVSDRSTPEDTSDSNNSGSTVLFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KAH6</accession>
    <name>A0A8J5KAH6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018441">
        <property type="protein sequence ID" value="KAG7169108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KAH6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="135" mass="14972" checksum="8431BBD683727EB9" modified="2022-05-25" version="1">MAESVEQGSTIVGDTLAERLEEALLIKARQYSALEESQTQVKELKQELQELKQELQHAKNQDTDLGYGVGRDTNPTDPPAESAHSVPQSGNDTTHPGSLRVDPGVLPKLTDIAKRDDGKQPCSTLVMLERYHWKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KB64</accession>
    <name>A0A8J5KB64_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">52 kDa repressor of the inhibitor of the protein kinase-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Thap12-L5</name>
        <name evidence="2" type="ORF">Hamer_G012290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KB64"/>
    <dbReference type="OrthoDB" id="6379362at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="1">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="252" mass="27942" checksum="301944079F3AF828" modified="2022-05-25" version="1">MDSIKEGGDIFAVLADEAVDKSNNEQLPLVLRFVDSERQIREEFVGYYECQSVTGEAIADIIKKVVCDLGLDFNKCIGQGYDGAGYMAGSCKGAAARIMADYPLAKYFFHCAAHKLNLCVVSTCSQQSIRYTMDTLGEFARFFNFSPPCQSLLGDKVQESCPRSKREKLLDICVTRWIGHRQVDAIEGFLDLAEPVLDTLETIANNHTGILNSDSKAKANGLYHTIATFQFIFAATLLREVMSLLRGLTTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KE46</accession>
    <name>A0A8J5KE46_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED17-L</name>
        <name evidence="6" type="synonym">MED17</name>
        <name evidence="9" type="ORF">Hamer_G013489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KE46"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="8">
        <location>
            <begin position="513"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7170669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="828" mass="92988" checksum="E351184B2B61DE09" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KEU4</accession>
    <name>A0A8J5KEU4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">La-related protein 6-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Larp6-L2</name>
        <name evidence="8" type="ORF">Hamer_G012463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KEU4"/>
    <dbReference type="OrthoDB" id="435402at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000158">
        <property type="entry name" value="La ribonucleoprotein domain family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12901">
        <property type="entry name" value="SUZ-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51938">
        <property type="entry name" value="SUZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="6">
        <location>
            <begin position="127"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="7">
        <location>
            <begin position="396"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7170894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="461" mass="49984" checksum="CCDD7E6252867E94" modified="2022-05-25" version="1">MAPTALAVMAKPVVAWQGDSIHGGRPHSQGKRQNKSCKTLTKATIMSDADTEGSSGAWRNVSITSSERDGPHIAVHSTSEDKDNDGTSATSIHSLLMVSGQHSLTTTDIGSDYTSEGGESNHEVGPQPLTPQLVAALVKQLEDYFSDDGLAKDLFLLKHVKRHRDGFVSLKLLSGYKNVKKISRDWRTLAAALRSSTTLQVNDEGTKVKRRAPLPPTLLYDAPSSRAIVAVNVPAHQATMAGLAVLFGTYGTVASLHVVRPKPGGGVPPELQTLVSRVPKIATTTCAVVEYEDVWGAARALQELINPPMTLHVLRRSRRPSPNSSRNSLTPTPTPKGRMRGENGVSAEELRQRLKCSRSKLRHIHNESSTSEGEDSGSSQSWWRQGSPHLTPQPPLRPTCHALNGCSMSTPSSPASYRRTQHHLPVTRHPRGPDGTRGFSRVRTLAGLGLLFHPSFHQSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KEZ9</accession>
    <name>A0A8J5KEZ9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Ecdysteroid kinase-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KEZ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="138"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="421" mass="48149" checksum="87CE0814F4F0F7D8" modified="2022-05-25" version="1">MVNGKEEDFITQASQRLIKETHVKSALEADKGSNAQLISWKVEDFTIKGDNYACVVTSIKVTYRQGGSEHKATYVAKCNPCRQHATLDEFVHMAFEKEAGFYQDLLPLLNTELIRIKHEPLRVAQCHFVHLVKGEEVIILGDLRLEAFKMFSRQKGMDKAHSILVLKELATLHAASLLVKAKTPEDLDVRYKYLQKDLSSLTDNENDKPTMFQKFALMSARMIEKIGGYNNVVEWLKDFGPKANDVFKEQVKKTPPFDVLCHGDCWNNNILFRYDKAGVPVDVRLLDFQLCRKSSPATDLNYFTYTSLEGPNRKDNLQTFLKTYHDSFTKVLQNAGAPVPFTLEELRQEYHNKNLFGLLIGIMILPLVVSESSEALDLSKAKGQKFLEEHLERMTNQLHNPVSRSRFLSMFEDMIEYGIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KF41</accession>
    <name>A0A8J5KF41_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Telomeric repeat-binding factor 2-interacting protein 1</fullName>
            <shortName evidence="8">TERF2-interacting telomeric protein 1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Repressor/activator protein 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trappc2l-L</name>
        <name evidence="11" type="ORF">Hamer_G013869</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Chromosome</location>
            <location evidence="8">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the RAP1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012946">
        <property type="protein sequence ID" value="KAG7171078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KF41"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0779">Telomere</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TERF2-interacting telomeric protein 1 Myb" evidence="10">
        <location>
            <begin position="151"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="TERF2-interacting telomeric protein 1 Myb" evidence="10">
        <location>
            <begin position="321"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="262"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7171078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="519" mass="60342" checksum="D9675BAD609C8C9E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KH83</accession>
    <name>A0A8J5KH83_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cc8K15.2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KH83"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="87458" checksum="A2DD4607CA37C874" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK43</accession>
    <name>A0A8J5MK43_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045000">
        <property type="protein sequence ID" value="KAG7154162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MK43"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="154" mass="17601" checksum="B974CA9B2011117B" modified="2022-05-25" version="1" fragment="single">MVVCGASVSTASVVAAVSRAKWTRISQDTSDGRDHGWPVTHLGYAWTRGKRVETKGKPYDELGHVLKLRDLTKTHTLTDVKTRRDTLKHPPTPQRFLKTYPREFRTRRYCILHPSSQTSGDGRRRSVSLHTSWDVASVSDARPQQPHPQPRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK45</accession>
    <name>A0A8J5MK45_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytospin-A-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Specc1l-L1</name>
        <name evidence="3" type="ORF">Hamer_G018189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044460">
        <property type="protein sequence ID" value="KAG7154448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MK45"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="310" mass="34875" checksum="64A5EEB77FA3F77A" modified="2022-05-25" version="1">MTTTGTNSEIMATKLKLPQRLSKESFRKLVSGMYGKSSLPAMPTPSFKNHIANGGEDPSSCGDRGEWDNKSTSSVSEMSVACLQDRIQQMEETHYCTNEELQATLQELDDLREQLSECHLEVQQLQEEKQSAQEDRELLQIKQEELEQQIATTKEAEERCHRDSQLIRDRMKLLESMVEAANSDKKATESQLAEALEATKATEIETTRLKTALDSAKEKITELEAAVISGEKSKLPDVLERVRQEKDSLEKENASLQQKANAMACENERLKDQISTLQDDLMVGCVEQSATVELPELNINQVKVTLVERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MM60</accession>
    <name>A0A8J5MM60_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Hamer_G006480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MM60"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7156514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="213" mass="24696" checksum="F675B86CE634F1D6" modified="2022-05-25" version="1">MVLLSLYRDKIGTEEPVEPKYRNLRERIMSSVYQSSSSSWSSPSSLSSFPTFPEFVQYVFGAQITLFPQVKCLMPYWAECGVCANDFNIIIKAETMTEDEQFFLTVADLGHSNMEVVKQQEEVKVQQQEEVVEGQQQEVVKGQQQEVVEGQQQKESSAAAAAVKRKESPWEEVTRYYSQLTRHQMTELHQRYKLDFDLFGYEIDAYLAWPEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MM74</accession>
    <name>A0A8J5MM74_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G-protein coupled receptor Mth-like 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mthl1-L2</name>
        <name evidence="12" type="ORF">Hamer_G006535</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Mth subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MM74"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
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        <property type="entry name" value="Methuselah ectodomain"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
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    </dbReference>
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            <end position="962"/>
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            <end position="480"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="641"/>
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        <location>
            <begin position="463"/>
            <end position="622"/>
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            <begin position="690"/>
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        </location>
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            <end position="903"/>
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            <end position="940"/>
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            <end position="713"/>
        </location>
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            <end position="724"/>
        </location>
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            <begin position="891"/>
            <end position="900"/>
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            <begin position="921"/>
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        </source>
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        <source>
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        </source>
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    <sequence length="962" mass="107495" checksum="D010FAE6DE3EFCE3" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNG5</accession>
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        <name type="scientific">Homarus americanus</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
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            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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            <end position="238"/>
        </location>
    </feature>
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            <end position="229"/>
        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="238" mass="26960" checksum="3864224CB89997C6" modified="2022-05-25" version="1">MFRKPRDDKHTKDPWRSREHCVDCGVLGNWRGILDGGLLCAVVGQRNVMGRTSRVVVVGGKETGKTSILERAIFANSTVDKQYIPTVEDTYVGIVETERGTREKLRFYDTAGLDTRNRSLPQHYHALADGYIIVYSISDYLSFQLLTDIKKDIDRHRDKKDVPIIVLGNKSDTAATNRAVDTATAERWASAEKVRLWEVNVQDRTLLLEPIMNLASRLNPQPSKTSFPQLTMGRKNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQA6</accession>
    <name>A0A8J5MQA6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Acid-sensing ion channel 1C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Asic1c-L</name>
        <name evidence="14" type="ORF">Hamer_G021135</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032328">
        <property type="protein sequence ID" value="KAG7159755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQA6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF300">
        <property type="entry name" value="PICKPOCKET PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035183185" evidence="13">
        <location>
            <begin position="24"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7159755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="163" mass="18223" checksum="3883ADC0EBB43888" modified="2022-05-25" version="1" fragment="single">MGRRIMWGTTLVVSLLVLVAVMGYQMNYFLSYPVNVDVQVIHSTSLRFPAVTICPYPRNNMMTMGRSPLAVREAYQQVVGEEYPGLRNASRELENLLNTKDLWDATAWNVSAMIHECYQGRGVLCNETGAFTLIYTLFGPCLTFRGAPTTLAGSYHGLYVKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQA7</accession>
    <name>A0A8J5MQA7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031898">
        <property type="protein sequence ID" value="KAG7159848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQA7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="97" mass="10227" checksum="5A9B4D9B451AC2F8" modified="2022-05-25" version="1" fragment="single">MVTEASGLQVATEEESPQVATEGDTPQEVARSAAAQKPKANRPPHQAKNTLVPGATGNLKSKAGHPTNTVAEARKAAAQQARAMAKERRLKTAMKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR19</accession>
    <name>A0A8J5MR19_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR19"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="433" mass="48324" checksum="1FB9BDD5AE3B70F8" modified="2022-05-25" version="1">MNYGSRWAETLVQADIASPGTANSFLKATHVTCTRRGHQITAATLNILQHKAYGKYTEDAQSNGHEPLEFGVWCQQRAECCPQNQTSRYTWMLWLNCLADKITDAPHVTSVILDEPAVVDMLKPGGSRTFQECSTAVFIPYIKSQLKHRSRLNLEWDCYLKSGSLKATVRCNRGKGIRRCVTASGPLLSNWQNFLHNSDNKEELFRLLSEQVMQLVVKESKQLVVTDKKQVLTVPPRNDTANLTPCNHEEADTRKMVHAADALECGHRRILIRTVDTDVVILAVALANERSEVLDELWLTFGTGKNRRYLAAHQIAKALGPEKSRALPVFHAITNCDMVSAFAGHSKKAAWATWNAFPEVTTAFLSLASTPSELPDGVLSTLERFIVLLYDRTSTCCDVNVLRKKLFSRKSRSLEDLPSTRAALGAAHKESCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR53</accession>
    <name>A0A8J5MR53_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Minor histocompatibility antigen H13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HM13-L</name>
        <name evidence="10" type="ORF">Hamer_G007610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR53"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7160850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="310" mass="34440" checksum="108240B21BF99BF4" modified="2022-05-25" version="1" fragment="single">ASGEKVDTMTSKDAAMFPIIASCALFGLYIVFTVFSKEYINLLLSSYFFVLGVLALSHVFGPVISGLVPASVPFETYHLHLMKGDKDKKDYIINYGFSSYDLVCMGVCALLGVWYLLKKHWIANNLLGLAFAINGVELLHLNNIQTGALLLVGLFVYDVFWVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGMEADNFAMLGLGDIVIPGIFIALLLRFDHSLNRGSNTYFKVTFAAYFAGLMMTIFIMHVFKHAQPALLYLVPACLSAPVLLALMKGDFKELLQYEDHPSIDEKEEGETTQDKKSAKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR82</accession>
    <name>A0A8J5MR82_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Rpl9-L2</name>
        <name evidence="7" type="ORF">Hamer_G025871</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031160">
        <property type="protein sequence ID" value="KAG7160639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR82"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="10"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7160639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="161" mass="15982" checksum="45FAD19955CA150E" modified="2022-05-25" version="1">MKLDMKTQKVKKGTVVSVDKWYGNRKEVAAVCTVCSHIANMVTGVTDGFQYKMMRAVYAHFPINCVISNNNQGGGVDRQDGGVGWEGGGVSCEGGGVSCEGGEVSCEGGGVSCEGGGVGCEGGGVGWEDGGVGWEGGGVSCEGGGVSCEGGGVGWKGSGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRV5</accession>
    <name>A0A8J5MRV5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox protein MOX-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mox2-L</name>
        <name evidence="9" type="ORF">Hamer_G007408</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRV5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042634">
        <property type="entry name" value="MOX-1/MOX-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328:SF7">
        <property type="entry name" value="BUTTONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328">
        <property type="entry name" value="HOMEOBOX PROTEIN MOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="109"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="111"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7161765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="210" mass="23168" checksum="51C9EF5F159FC1DA" modified="2022-05-25" version="1">MRWMSMREIGCKTIRDLRSSPLVPTTTSTPLPPQRPSIPLPHPLNSLPSPYPTPSTPLHPLTPSLNSTPSPYPTSIPSILTPLNTPIPPSLNSSIPYPYQDALKADLLGKPRKERTAFTKHQIRELEAEFQHSNYLTRLRRYEIAVSLDLTERQVKGAHLEDPYTGLHHALAPSTPSTLASSPLEDGGPYSGLHHELGDTNTYLAEGETC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MST2</accession>
    <name>A0A8J5MST2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 846-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Znf846-L</name>
        <name evidence="10" type="ORF">Hamer_G008074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MST2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7162518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="165" mass="19146" checksum="F1C08546DB4B50F0" modified="2022-05-25" version="1">MRAREDSETPGGGATGPRTSHTSTSKLHQCTYCSYSTYRKDHLKIHIRTHTGERPYACQYCPSRFIQTNALRKHLLTHTRDKVMLHQCTYCSYSTPRKATLIIHMRTHTEEKSYSCKYCTLQFSSSSALQSHICTHPTEKVFRCSMCPQVFDHYKALKTHMLNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MT25</accession>
    <name>A0A8J5MT25_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Piccolo-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Pclo-L1</name>
        <name evidence="3" type="ORF">Hamer_G002269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MT25"/>
    <dbReference type="OrthoDB" id="6352364at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035275941" evidence="2">
        <location>
            <begin position="18"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7163190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="294" mass="32684" checksum="3FFF436761221A51" modified="2022-05-25" version="1">MRTIACVLLAVAGMTAAQSPTRADPGFGTSATASSTPTATTSVAGNAPPQAPGKNNYGPRFFGPGITNPLGRPINPMVVQHAQKVLAMRPDLKVYVDFDGQMHFTNQYGIEVDEILDEFGRDLSELLDVQEQQERLFHAQRQQQAPFNAQNEQQAPFNTQHQHQVSFNAQSQQQVPFNPQPQQQVPFNPQPQQQVPFNPQPQQPVPFTAQHQPQAPFNIQHQEQFIQRAPNSGSEQELASAFLNKEFERRHKMLEQQLLQEYRTNPAAFTSPVRTNGGGLDGRTQTQAGRRVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MT78</accession>
    <name>A0A8J5MT78_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7162983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MT78"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="117" mass="13639" checksum="33435EF287C2E2B4" modified="2022-05-25" version="1">MDAGTTNYTTEDVATELCSDHEQNPRHPSLGKWGMDDDDDDDDDDDDDDDDDIHAERRKRKGEKRIEKERQFQLALVDKQVLARSQGLDTKENVFDVTRYAQMVPKFDENDPLEFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTQ1</accession>
    <name>A0A8J5MTQ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTQ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="128" mass="14583" checksum="9A0083F3C385A52F" modified="2022-05-25" version="1">MEGKCHKRPRKEHNISDIDNMSPAIHPVAEPPTFAIPTVMKYKIPKETEFNHAYEEVVALELEYKNIKFSVKPNLVGDLILSPQDHNTAKILSEVSNLNGKTVKILPLDPEEKTTRMVLLRYPLELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUK6</accession>
    <name>A0A8J5MUK6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025553">
        <property type="protein sequence ID" value="KAG7164181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUK6"/>
    <dbReference type="OrthoDB" id="6334013at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035278844" evidence="1">
        <location>
            <begin position="18"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="136" mass="15358" checksum="E0BC3BFFA14AD3BA" modified="2022-05-25" version="1">MYMSTVLLTTLAALAWAQDAPECHCGMFITAFHNEYLVHLLPPFDLDDCSAMEACNSKCNDEFDALTGGGYLNYSLNNGFTVGQELCLTMLTEYDIDHVEEETVYGYARQCNGPWDYDGGSTFDQLCCWEGRYYEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW68</accession>
    <name>A0A8J5MW68_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G010357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW68"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="193" mass="21675" checksum="DD0B03B16D4C8E05" modified="2022-05-25" version="1">MLQMSGIWTSPIQMPQKSEMWHLQPKPQDRNVYSKTQGRSHHDSQVPKLWKETSRLEHIIPREERADESCNGKNASTKHNRSTSEHIRVGSTATENSQPNTHSAPTVRGFLPCTSPTRLQEKIEDTGTKSVKQETMTNQWTPQPQLKSCIAVRAHNTPVLVENTILPGTLQPPQATTQLNTPQPANLQAAFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW90</accession>
    <name>A0A8J5MW90_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Neural-cadherin 2-like 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CadN2-L11</name>
        <name evidence="7" type="ORF">Hamer_G023659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023849">
        <property type="protein sequence ID" value="KAG7165712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW90"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000112">
        <property type="entry name" value="neural-cadherin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="45"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="157"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7165712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="271" mass="29597" checksum="51DFCB0A84FB2F75" modified="2022-05-25" version="1" fragment="single">PLDRDPPHGRSQWRLRVRATDGELETTTAVHVNLKDINDNPPFFPVPVVNATISENTPEGASVAQVSATDNDDPREGHNARLVYSLEKNVIDEASGRPIFAVDSEQGLITTALCCLDREKTQRYAIQVVATDGGGLKGTGTVLVEVADVNDVPPRFSKPEWTLDVSESLTPDHVLATLSVVDQDISNNFTFRVVPGSGRGWQMFRVEGRRNGGPGGDLRAVAPLDYENPDHRRGFRFRVQVTDMAHLTLAEDTPAGTHLATFTAHDIDGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWE4</accession>
    <name>A0A8J5MWE4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-directed DNA polymerase from mobile element jockey-like 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G023535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024174">
        <property type="protein sequence ID" value="KAG7165529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWE4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="138"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7165529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="853" mass="95344" checksum="3C6ACADA93876FDE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MX45</accession>
    <name>A0A8J5MX45_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Calcitonin receptor-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Calcr-L3</name>
        <name evidence="15" type="ORF">Hamer_G011010</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MX45"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF42">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR SEB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="646"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="13">
        <location>
            <begin position="325"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="412"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7166189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="722" mass="81217" checksum="DB83F408311F263F" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MX99</accession>
    <name>A0A8J5MX99_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MX99"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035297499" evidence="1">
        <location>
            <begin position="31"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="263" mass="29786" checksum="6C7E2E2A53DDA5E7" modified="2022-05-25" version="1">MVVAERARVAAAGVLVTLTVVLVTLAAVNATPASTSSDHSSSNLLKHLTFLYKDTYVLYGNGRRSERDLPICSSRGEACNLAHRRFWLTPITERLCRCADRSECPLHFGGLNDTLSQHVSNRAQLKFCGNVMTFLEECKQGEVALKLHRVERQNQPFPSSSVREGFDTHTTVMCRCPWPNLWTLVDTRTPSPTEKLYFYTCNELTKCKRWEECGHIRNDTLESYYMCSCPEHHMCVFKGSQPTHITTQLHFHGHAYTGICTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXB8</accession>
    <name>A0A8J5MXB8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mbt-L</name>
        <name evidence="7" type="ORF">Hamer_G010478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXB8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06648">
        <property type="entry name" value="STKc_PAK_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000073">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF8">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="528"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7166807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="800" mass="89258" checksum="417B20986D0A27CE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYE7</accession>
    <name>A0A8J5MYE7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-xylulose reductase-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DCXR-L1</name>
        <name evidence="3" type="ORF">Hamer_G019076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021370">
        <property type="protein sequence ID" value="KAG7167674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYE7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7167674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="163" mass="17508" checksum="4DD0C5F48A089A9C" modified="2022-05-25" version="1" fragment="single">MASNNKTECTMPGTCVWGAGRVALVTGGARRVGRLITLALHRHHYNVIIHCCSSKLLALELAAELNSCRQDSAHVITGDLSQNVGETTRRMVTEAEQKTRNINLGGGVDHTQAAAPHLQKVRGNIVNVADILAERPTSTLNIYCTTKATLIMITKSLAIELGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYL8</accession>
    <name>A0A8J5MYL8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Ccna-L</name>
        <name evidence="8" type="ORF">Hamer_G018369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7167944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYL8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20504">
        <property type="entry name" value="CYCLIN_CCNA_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="101"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="194"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="198"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7167944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="316" mass="36341" checksum="A23DE359E8B60506" modified="2022-05-25" version="1">MSSTTNSSVPLPLRERSSDIESSASTDPMEMSVCEDDLMVVETTPREDVLQSRNDDIYDVPEYAADIYQYLREAEVCHKPRANYMSKQSDITSSMRWILVDWLVEVAEEYSLHTETLYLAVSYIDRFLSHMSVKRDKLQLVGTTAMFIAAKYEEIYPPDVGQFAYITDNTYKVGQILRMEHLILKVLSFDMAVPTAHLFVNKFSRMCKNSEETLNLALFLAEVTMLDCDPFLRFLPSMIAASAVALANHTQGRVAWPSHMVESTGYALEDLRECYVNLYRAFSRVHEPQQHAIRDKYKSSKWHGVSQLSPRQNFPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYW0</accession>
    <name>A0A8J5MYW0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016480">
        <property type="protein sequence ID" value="KAG7169460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYW0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="188" mass="20462" checksum="6AA8826BAAD265D8" modified="2022-05-25" version="1">MLRSIGRQSVLQIILHPGSSGCGGSNKFLFHTNYTPHPCRQLELIVAGKNDGQPRGSTTWSLPGACRTPHLLCSNQPYPGRHHLSQHQPHLSPEGQTAAPTRPSLLVFSVAHNTPMQGSYHATLVQVVWSGGYFAHLAFVPRLMRALTPGTWHPGLASPGDQVWPTVKGRDESFNMPMIHGDGRGLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1L7</accession>
    <name>A0A8J5N1L7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Hamer_G014663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the clarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1L7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026748">
        <property type="entry name" value="Clarin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548">
        <property type="entry name" value="CLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548:SF1">
        <property type="entry name" value="LD47387P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7171537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="83" mass="9365" checksum="926F7897AD0E414B" modified="2022-05-25" version="1">MNILKRGMVFITFFGCCFAIALMAAAMSTKFWLEAEAIQRRINPDNRIEVRPNSTGHVNFGLFKGRKSLNVGFGTRLHPFDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2R8</accession>
    <name>A0A8J5N2R8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-threo-3-hydroxyaspartate ammonia-lyase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">thadh-L</name>
        <name evidence="5" type="ORF">Hamer_G001062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2R8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070179">
        <property type="term" value="P:D-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="4">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7172069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="109" mass="11811" checksum="63DDD6B50C1B5553" modified="2022-05-25" version="1">MLWPDSPSFLNTVADSIRLQAIGHLAFPIICDNANSRVFTVTDDQMIEGMKLSFERLKQVVEAASGAGVYAALNLINDVQPMARKVGVILCGGNVDLENLPWIAATTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N377</accession>
    <name>A0A8J5N377_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011213">
        <property type="protein sequence ID" value="KAG7172421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N377"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="285" mass="31961" checksum="D21B1B76877B64D6" modified="2022-05-25" version="1">MTVIGGVADWLGYRGVPTKPANQPSSPPDRGPQCIYTKREVPKEARAEETYRCGAVDPWPGPLYSLSWWKDGSQFYRASVAYSIGNPATVFALPGIKVKIRLLPALSWSGTRSATTQERCWGQLYCAESSPTPVFTWFINGLQPLQVEDGYRRCWRSPKRPTSPGLPPPGSPSDSRGTTSPTTRSTLPNSTTPFTTTDTSTNAQRRLQRHHQPPTPSALPCHHNVSYVTTTWEESKGEMQPRRHDRDSKKLIAHRQAHAGQDCPQEVVHISRPHHDRRLRRSMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4C0</accession>
    <name>A0A8J5N4C0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Rnmt-L</name>
        <name evidence="15" type="ORF">Hamer_G008702</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="10"/>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4C0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016899">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028762">
        <property type="entry name" value="ABD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10 12" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="14">
        <location>
            <begin position="38"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="47"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
        <ligandPart>
            <name>mRNA cap</name>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="12">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="12">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="12">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="12">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="12">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="12">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR028762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7173167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="351" mass="39991" checksum="4AD956A4E4DA0298" modified="2022-05-25" version="1">MADSESRSGKRHCDGVGSIVANHYNSIEAKGLKERTKSRIFFMRNSNNWIKSYLINYCLEQIRDRQVDDYPISVLDLGCGKGGDLLKWQKGNIKHLICADIAETSMDQCQERHEINKRKGRGGLFSAEFIVADCTKRRIKPLFENPSKKVDLVSCQFAFHYCFESLDQAETMLCNVSENLKKGGYFVATIPNANEIMSRLKATTGNSFGNEVYRIEFPEDRPKKSSLFGDRYNFFLEGVVDCPEFLVHPPTLENYLHIGKSNMLPLCTTTLVSISQMLLLGQSKSKTHRNKYKQNPSNYPTDEQSTETDGEYSHAQEHLASKEGVSRIRTLSKSEWEALCLYRACVFKKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N556</accession>
    <name>A0A8J5N556_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Facilitated trehalose transporter Tret1-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Tret1-L4</name>
        <name evidence="12" type="ORF">Hamer_G008523</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N556"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF96">
        <property type="entry name" value="FACILITATED TREHALOSE TRANSPORTER TRET1-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7173005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="445" mass="48065" checksum="6037D0E6C9BF2373" modified="2022-05-25" version="1">MGDLAEEMKEPAGSVKEPIGSMRDPANKSHVTYQESWVGAAMPACALVGSLATGTLVDRLGRRATLLHLTWPLVISWVMIATSEGVGGVVVGRMVGGVCVGAQTAARLVFMSETVQLNLRDVLAAIPALSANLGLLVSFTAGEFLSWRGLAWLGAALSLPVVLLLLPLPETPSHLTRIGKKEASLAALRQLRCTPQDAEQEQQQISNSFSSRENNSHVSVWELVQPPNLWPVSVAASLMLAQQATGFTAIVSFTSTILDTGKEGTSNSSSTFLLGVVNVLGTFVTLFLLARIKRRYLLFVSTVMIVASLLTLSLFFWAKEAGGYISIMAKTLYLVPTLALVAYMFASSLGWRIIPWVFLGEGMPSRVRSNGVAMAVAVHWASSFLITKTFGWCMSSLGAHNTFLGYAVLTSVSYLLLHRNMPETFHLSPAQMDEIYNKAANKKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6D0</accession>
    <name>A0A8J5N6D0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6D0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31904" checksum="EAF672A72D0BBA81" modified="2022-05-25" version="1">MYSINGLWVINDSCLFSSVDMVVMAAKRSFRDAWLNNEDFQPWLSRVEDNPSRAFCKICKREVSAELTAIKRHKTTKMPAVYEATEQQEVQQERIPVHHKNYVANGVAVATILFACFIAEHNLPFTTADHLVDLTKRMFPDSVIAQGMNMKRTKCTEVVRTLGRCVTEDLVDKLRENKFSITVDETTDISTMKASSVLVRFWDSTTNSIKSGLLEMINVYDDQWRDLDVIAIPPEIKDSSDIVDDFTKLRELKDGVGVSQFKDLCTFALQSVDVHYGMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6D5</accession>
    <name>A0A8J5N6D5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hAT family C-terminal dimerization region-containing protein 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009749">
        <property type="protein sequence ID" value="KAG7173468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6D5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="127"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="177" mass="20399" checksum="93607E75E33593A9" modified="2022-05-25" version="1">MEKDGQIKQILAKVSKLVIFCRKSTVAAEVLSNEFKLQMITCTSWNSQLTMMRSVLRFLTETRLNKFESMEAFQLAATLDPRYKLDWCHDYDNEVQDICDLTLKYNVDPITTDTSPAEPPPMKRNKFFALANQLAAKYLAILATSAPVERLFSIAGKLFRPERCNLSDKRFEQLMMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6H7</accession>
    <name>A0A8J5N6H7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde oxidase 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G030736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008434">
        <property type="protein sequence ID" value="KAG7173959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6H7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908:SF132">
        <property type="entry name" value="ALDEHYDE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7173959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="313" mass="33363" checksum="660867CA69421985" modified="2022-05-25" version="1">MIPDMSRSVIANDSMVIGADVSITRLISELSEAGDSLSGFAYLKNIAETWKAVASTSVRNMGSWGGNIAAKVLHPEFPSDIFLGLLVAGAVITTGGPDGSLEKYNLEELLEVDLVGRRRVILDVVLTPASEDTVVRTFKIPPRPSNTHAQVNAGFRLQVDATNAHTVTGSPIIAYGGVNPSFVRAKATEEALKGMSLEDEVALQGALEVLAGEVIPDNNPEDASPEYRVALTQNLLYKTILGIIGDVAASTFTSGATNIIRPNSSAKQTFDQNTDVWPLAEPVMKLEAPIQCSAEPQEKLEALHSVVVSKKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6U3</accession>
    <name>A0A8J5N6U3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6U3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="147" mass="16570" checksum="2058C9D0EA939EF9" modified="2022-05-25" version="1">MKFGTSKSRKYIPAQLGNNMLTTLPAFNALTGSDSTSLFASHTKKYCWNVFKEHQNLLKLLGKGDLCEKAVRDTEEFICRVSKCNAANSVDRARFILFGRAHPLETLPPTCDTLSFHIKRKHYQPSSWQQAGMQFPCCPLLRQGDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N780</accession>
    <name>A0A8J5N780_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008624">
        <property type="protein sequence ID" value="KAG7173903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N780"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="242" mass="27550" checksum="C8C06D197002713D" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKMKSEEAIQRGRAVKVPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N885</accession>
    <name>A0A8J5N885_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G016380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N885"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="73" mass="8389" checksum="11340171B7B56745" modified="2022-05-25" version="1">MQLDVAMTLLKNTKASLVSYHENGFVSAQASAKDMCEEMNVEDVLKEKRLRMMKRHFGYEAPDEPISDALRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N932</accession>
    <name>A0A8J5N932_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kazrin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Kazn-L</name>
        <name evidence="4" type="ORF">Hamer_G021864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006264">
        <property type="protein sequence ID" value="KAG7175123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N932"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="Kazrin"/>
    </dbReference>
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        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12776:SF1">
        <property type="entry name" value="KAZRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12776">
        <property type="entry name" value="KAZRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25986">
        <property type="entry name" value="Kazrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="376"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="459"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7175123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="806" mass="89862" checksum="E16ECC723AD04F81" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N969</accession>
    <name>A0A8J5N969_HOMAM</name>
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        <submittedName>
            <fullName evidence="10">Krueppel-like factor 2-like 1</fullName>
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        <name evidence="10" type="primary">Klf2-L1</name>
        <name evidence="10" type="ORF">Hamer_G025114</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Multicrustacea</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006281">
        <property type="protein sequence ID" value="KAG7175119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF158">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
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            <end position="369"/>
        </location>
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            <end position="139"/>
        </location>
    </feature>
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            <end position="60"/>
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            <end position="116"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7175119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="369" mass="40740" checksum="0549C30D25568D2B" modified="2022-05-25" version="1">MAEYLDMWQDIETVLLGDIKFSTSEGANTSFMPAAHPQPPAHPHTHLHTLHLPPSSHVQVPSPPQHPTHTQQHVHHQPPTHPQPPSTPTQQAAPQPPNLAQPVSRMTTVSGVSSCQPEPRTLSPASGEACPSSAPYPASYSTHHWRVKSEYGEQVVPEGSWEYKEGSWTEYYPATDPGLQYGYFPSTPPYPADLYPPPSSGPPAYQPGLPVMSTNPLLTPPSSPSLMGGQVPTGLSGPLAPNMASCLPVGLPHGFPTVGPQQQAPAKPKTRRRRTWTRRKAIIHTCSHNGCAKTYAKSSHLKAHMRTHTGEKPYTCDWKGCGWKFARSDELTRHYRKHTGDRPFQCRLCERAFSRSDHLSLHMKRHMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAK4</accession>
    <name>A0A8J5NAK4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004078">
        <property type="protein sequence ID" value="KAG7176141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAK4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="506" mass="57778" checksum="C0A6883F97E32F0A" modified="2022-05-25" version="1">MSYEMWRTTFKLHTDIAVATPVHPRLRISFSVYQEDNVKESDKDGEIYSEEAGEQRRGPLVYSGETGQTGVSVNRCRSLFTITGVPDEKTLFAAHLLQYPADNSSLTSDRWTPLHPRGDQHLSAGVKGVRHLLQKRSSSSGASTEDYRSLAALLPTLLTFEHNTNKSQEDDQRMEGQTPILRLNSRIDANGGVLPYVPCAIVPFDHPPSVTACFAHRLKNNNSFWIAFMGDSKIRALFFEFLQRTDSEYRMFMEPTPSKIQETKELRQLSRWARGEDSLPHILIIGYTSWMMQLMMMRRSYTSDVLEVMREMHQQVVPLLHQIAQRTRVLVVAQGRYREHSFTVPIYNMASILGDATFDWSEMLFQYYLRQYKDHHLSPATPHVSYTFPTPITGSLQQHSPVPQGPTTNTAIQQTTRTNRDHLDPRETGGGVWWWDTGVPLNLAGISECEELYRRGLVDSSVYTSEHLRCTDDHHVGEDVLSDQITMLLNLMCNSIMQPHTNVCCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBQ1</accession>
    <name>A0A8J5NBQ1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">N-acetyltransferase 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">N-alpha-acetyltransferase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Naa40-L</name>
        <name evidence="18" type="ORF">Hamer_G000281</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBQ1"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000033">
        <property type="entry name" value="N-alpha-acetyltransferase 40 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="67"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7177055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="233" mass="27246" checksum="BAB22D9E7C440AD8" modified="2022-05-25" version="1">MNERQLKKSKSKEKGKERRTALKAERARLAAAQLLVNQANAMPDPLSKFPFFNKYERNGLSCTLICKRVKDLDPDMLEWAIDLCKQNMQPLYEKSTQGWHENEKREEMMEDAAWYLMAIDTTSEKAVAFSHFRFDMDYGDEVLYCYELQLEADCRNKGLGKFMMQVLELMAFSNQMHKVVLTVFKHNPDGMAFFTKCKYEIDETSPEDTYEGSYDYNILSKLNKMKPTQKTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBW7</accession>
    <name>A0A8J5NBW7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G015553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBW7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="109" mass="12235" checksum="EF83DFD0A34D9AA9" modified="2022-05-25" version="1">MAVIVVFNGYLEKPSTKDVTHVGRGMKYVGASVKISGFMVFQRKKEDFLYNVVNKQNFIYLLADHLTQSGCCDKHAKADADLVIVQTANATAHRIPLSLQSWLLMTQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCJ5</accession>
    <name>A0A8J5NCJ5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G020911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001665">
        <property type="protein sequence ID" value="KAG7177845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCJ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="99" mass="10851" checksum="9C6247A23500DCBF" modified="2022-05-25" version="1">MACASASSVWCYRALQREAQAKIKQVEPNSVTLLVKETASVPCQRLLGGCEHLPPHLSSPSSNRDSELLQTGVDTLTQTDTCSFNYLLIRHLQPPGDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCK1</accession>
    <name>A0A8J5NCK1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MON2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mon2-L</name>
        <name evidence="4" type="ORF">Hamer_G000468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCK1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34199:SF4">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34199">
        <property type="entry name" value="NUMOD3 MOTIF FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HDS" evidence="2">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="3">
        <location>
            <begin position="59"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="3">
        <location>
            <begin position="276"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7177207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="717" mass="79685" checksum="B06F5178465AC010" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDC6</accession>
    <name>A0A8J5NDC6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein alan shepard</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">shep-L</name>
        <name evidence="8" type="ORF">Hamer_G025075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Has a role in the perception of gravity.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002133">
        <property type="protein sequence ID" value="KAG7177484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDC6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12244">
        <property type="entry name" value="RRM2_MSSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000169">
        <property type="entry name" value="protein alan shepard isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000012">
        <property type="entry name" value="RNA-binding motif, single-stranded-interacting protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="108"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="187"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7177484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="450" mass="48693" checksum="7A9E0CA27F84715B" modified="2022-05-25" version="1">MCTRRENLVVGMSSPGRLSQLAPVDLDIANGTKLHPPRSHTSQLSYGGGGQVPPVSPITTPTSTGGPHGGGAGGGGGGSGGGGGGGAGGYSATSPSSHSSYGEQLSRTNLYIRGLSPETTDKDLVDMCKKYGNIISTKAILDKNTNKCKGYGFVDFESPAAADKAVKGLQASSIQAQMAKQQEQDPTNLYIANLPPQMNEAELEQLLAQHGQVISTRILRDNNVQSRGVGFARMESREKCELIIQMFNKKVLRGAKEALLVKFADSGNKKRNQYKAKEQSNWERSAEPIPVYDQSSMLPQNGTLMPSVGPGTFRQYPSQVPPYHHLQPFYIMQPQTLQHMDMPQMMQTPMDTSQLSYSPVMPTLATHMQQLHLAPNTVSAQNDQMNNLLHQGYLTSGGYPPSPYTPMMQHLAMMEDSTAHSPDEYQPYPTTPGPVQCQPQPKPGVRNSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDM1</accession>
    <name>A0A8J5NDM1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Ecdysteroid kinase-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDM1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF56">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="218"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="361" mass="41305" checksum="51B9C03E59CED843" modified="2022-05-25" version="1">MFIRLGVFHTSSEYWSAIWKSMEGSGAEQIAFPSDLCASGSINKVLNGKHHCRYVLKTLLIDHRLPTWVERFAVVPADKAVVATTESTALAGPQSNITEAHVKRVLKADKGSNAQLNSWSVKDFTQKGDNYANVVTSVSVSYSIHGKDQSVSYVVKINTKHNVDNEMDFFIAILFKKEAEFYEEIMPLLNSELTSVGLRELRMPTWFHTHCEDGQDMIFLENLRPQGYQMFDRRKVMDVPHATLVLQELARMHAASRLLQARTPDEEFCDQFKYIKTTWTNFCDTAKEMVNNFFASTICNAEEMLHKVKGYELAEQWMAKNKTDTAGVIERHLIRDPKFDVICHGDCWNNNVLFRFLKVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NE10</accession>
    <name>A0A8J5NE10_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002184">
        <property type="protein sequence ID" value="KAG7177478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NE10"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="163" mass="18321" checksum="C7AB5629A9CAE283" modified="2022-05-25" version="1">MHAYNMIFEEDVGAAITKACELDSDSDAVHLARAAQIVRRHMFGEAKPFNGFHQECQEESVPSLLLGLVNMVLEGPSINDQIADISPAALTIAQLLRFNSFKHKRVHNATTSLTEMHSTSQESPVPLYMGMMLHAHTRNRELVDRLLHLGLSIFYDRVLRLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NEQ8</accession>
    <name>A0A8J5NEQ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Argonaute 3-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Ago3-L3</name>
        <name evidence="1" type="ORF">Hamer_G031034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001195">
        <property type="protein sequence ID" value="KAG7177909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NEQ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="126" mass="14783" checksum="ED937DC49561578F" modified="2022-05-25" version="1" fragment="single">NILLQCCKIYKGQRVVKKLSDRETAQFIRTTAVPPATRKKQICNIHRTNDFTQDPMLKNLQFSIAERPLHMEGRILPAPELLMDAPVQPREGVWDARRRLFYRGADINTWVVMNYNPRFVDQRSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T2L4</accession>
    <name>A0A8J5T2L4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Receptor-mediated endocytosis protein 6 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GAPVD1-L</name>
        <name evidence="12" type="ORF">Hamer_G001160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GAPVD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.80:FF:000001">
        <property type="entry name" value="GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="10">
        <location>
            <begin position="209"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="11">
        <location>
            <begin position="1175"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="483"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="551"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="768"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="960"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="554"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7172154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1304" mass="145018" checksum="4C7E645C2FFEDC56" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T2P6</accession>
    <name>A0A8J5T2P6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G009508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T2P6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035275996" evidence="1">
        <location>
            <begin position="33"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="195" mass="21734" checksum="6308B8C707621A10" modified="2022-05-25" version="1">MGGPYCVYPGRLTLRTAALVSFVVLLWMVVDEAPGSVGKVNIFSVAEKEASTPLVAGDHRRSTPAMETFLSDVQEHTKTPNDGKTAIDGESAELQQEFHQRHAHLLRECQRLNITKSSFPPSYWRRGNEVNVPEHLRMCVPNKVGSSSWKKNVKPKVENIVPGGQRNVEAIIVRHPLSRLTSAYRCMLCLVCLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T397</accession>
    <name>A0A8J5T397_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Ddx1-L</name>
        <name evidence="13" type="ORF">Hamer_G020319</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The helicase domain is involved in the stimulation of RELA transcriptional activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="JAHLQT010011048">
        <property type="protein sequence ID" value="KAG7172439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T397"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17938">
        <property type="entry name" value="DEADc_DDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12873">
        <property type="entry name" value="SPRY_DDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000076">
        <property type="entry name" value="ATP-dependent RNA helicase DDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000652">
        <property type="entry name" value="ATP-dependent RNA helicase DDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="21"/>
            <end position="198"/>
        </location>
    </feature>
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        <location>
            <begin position="232"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="389"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7172439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="568" mass="61909" checksum="002AF7BDF2529538" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T8N6</accession>
    <name>A0A8J5T8N6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G018702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009960">
        <property type="protein sequence ID" value="KAG7173416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T8N6"/>
    <dbReference type="OrthoDB" id="6360987at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916:SF18">
        <property type="entry name" value="IPT_TIG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035302118" evidence="2">
        <location>
            <begin position="17"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7173416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="775" mass="86791" checksum="163B14C323EF5D1D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T8Z2</accession>
    <name>A0A8J5T8Z2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cuticle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G025915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009687">
        <property type="protein sequence ID" value="KAG7173491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T8Z2"/>
    <dbReference type="OrthoDB" id="6375705at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035153950" evidence="4">
        <location>
            <begin position="17"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7173491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="149" mass="15614" checksum="FC3EEE83D9C1F5CC" modified="2022-05-25" version="1">MFSKLVLCVLVAVVAAKPQGGYEAPQQSYTSSGPVVPIVKDERQGPDADGNYNFDFETGDGISRQEQGAPHGETGAVAAQGGWAFKFPDGSPGIFNFVADAAGYKVQSDLLPTPHPLPAHAIQQIEFARQQEAAGPGPQYGSPPTPGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TCB0</accession>
    <name>A0A8J5TCB0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008575">
        <property type="protein sequence ID" value="KAG7173911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TCB0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="253" mass="28726" checksum="04F0B0972F38EB71" modified="2022-05-25" version="1" fragment="single">LYKDEEKVQKSVNDQEADVLSTAILTKEICPRTGVLHISQLSIEGSKESILRKEMISYEKNMDCFSNKQFGFISGRSTSPTVDKGTRQVDEIIDDSRAVDIWTAELSPRKNKYMRDRKNKSLATMDIICTPRSKKTTKNFRSSGCTYFKGSVLLWLGHLVENVQEGCQIASTDQGFILKERLRKLQLPTLAYRRSPWGPGVETYKIECSQMREADTTRGTQRRSLQNRQAKSPEDTRSRVGLSTTGMGYLSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TEL2</accession>
    <name>A0A8J5TEL2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TEL2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="65967" checksum="A120468D414127DD" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TG45</accession>
    <name>A0A8J5TG45_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclease HARBI1-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Harbi1-L3</name>
        <name evidence="4" type="ORF">Hamer_G003190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TG45"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7174270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="172" mass="20163" checksum="854367A1EF62443E" modified="2022-05-25" version="1" fragment="single">LRRERRYLDPLNPKNISDENPLRYYRFPLREILRLCEELDPFLRQRMTRSHAVPTHRQVLVALRFYASGTFCNVLGDTVGLTQASVSRIIRNVTQILSDMARNEIKMPTGAWVPIRAIPHDTIRNPLTLAEVRYKRSHTKKSVVVEQTFEILKSRFRCLHRSGGSLQYYPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIA8</accession>
    <name>A0A8J5TIA8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine threonine protein kinase-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIA8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="185" mass="19402" checksum="39B940C53EF1817F" modified="2022-05-25" version="1">MTLDAFITAKPSTPSAPTTPCTSKQNTGFRQLFKTSIKPQPSTSEPQPSTSEPQPSTSEPQPSTNEPQPSTSEPQPSMSELQPSTSEPQPSMSEPQPSTSEPQPSTSEPQPLTSEPQSSTSEPQPSTSEPQPSTSGDQQLSVQIDSDNESEVAGDPGSDDESEVANDPGSDDESEVANDPGSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJN4</accession>
    <name>A0A8J5TJN4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Splicing factor U2af 38 kDa subunit-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">U2af38-L2</name>
        <name evidence="16" type="ORF">Hamer_G009780</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJN4"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000122">
        <property type="entry name" value="Splicing factor U2AF small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="53"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="196"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7175770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="241" mass="28724" checksum="27442B9D6FBA2536" modified="2022-05-25" version="1">MSMSGAEYLASIYGTEKDKVNCSFYIKTGACRHSERCSRKHNKPQYSQTVVMQNMYVSQQNSAKSADGSHLANMSDHEIQEQFEYFFEDVFFECEEKYGEIEEMCVCDNQCDHLRGNVYIKFRREEDAVKAAEDLNNRWYMFRPIYCDLCPVADFREACCRQFEMGQCGKGGFCNFWHVKPISHHLKNLLARSSRSRYKYRSRSRSRSRDKHSDKHTDGKHRRRSRSRSRDRDRRDRRGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLT7</accession>
    <name>A0A8J5TLT7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo-keto reductase family 1 member C13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Akr1C13-L</name>
        <name evidence="2" type="ORF">Hamer_G023040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006389">
        <property type="protein sequence ID" value="KAG7174902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLT7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="255" mass="29677" checksum="141BE2B0CBA23475" modified="2022-05-25" version="1" fragment="single">EDITLTRRNVTHAVNRKISYIESAYSHNCEKVIGQIYEKAWLRGYKRRQFFVSSKVPMIGYEGHLASKFMKLSRRNLGVQEMDACFVEGPVGLQGKDLNDVCPVNEKGECILDEGSDFIRVWRTMEDQFLLNHTNFIGLCNFNIDQINTICQWARFPPHMVQMDINVYNMRKEERRILREWRIKIIATHIFGSPTFIPTYALFTGAIPRSRKCILNGSITKNITKFQLSYEEMVMLNKLDTEGAARLMDFPDYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TR17</accession>
    <name>A0A8J5TR17_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amine sulfotransferase-like 4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Amine sulfotransferase-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Sult3a1-L9</name>
        <name evidence="3" type="synonym">Sult3a1-L4</name>
        <name evidence="3" type="ORF">Hamer_G028790</name>
        <name evidence="2" type="ORF">Hamer_G031527</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003009">
        <property type="protein sequence ID" value="KAG7176733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010001303">
        <property type="protein sequence ID" value="KAG7177892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TR17"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="86" mass="10111" checksum="08C4EAA680D31548" modified="2022-05-25" version="1">MAKLEKLNEFLSTNLSQKQLLYVAKYTEFNEMAGRDSLVGPKTKDNPQYSQEVVRQEGCFFRKGEVGNWKEKLTLDQVHKIDKWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TUN3</accession>
    <name>A0A8J5TUN3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002051">
        <property type="protein sequence ID" value="KAG7177498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TUN3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="778" mass="84708" checksum="143788303901D110" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TW43</accession>
    <name>A0A8J5TW43_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TW43"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7178172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="59" mass="6433" checksum="0E10A51686C71A5E" modified="2022-05-25" version="1">MTNQWTPQPQLRSCIAVKGQNTPVLVENTILSGTLQPLQATTQLNTPQPANLQAAFTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J9M1</accession>
    <name>A0A8J5J9M1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G024020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046676">
        <property type="protein sequence ID" value="KAG7153543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J9M1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="59" mass="6931" checksum="80BA458543BDDB56" modified="2022-05-25" version="1" fragment="single">MAEFANAGFWLLVEEENNILHCPNCKKVVEWCPFFFVTHAYEIVVYLSNMLSVNIFKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JAL4</accession>
    <name>A0A8J5JAL4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Pyrokinin-1 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PK1-R-L</name>
        <name evidence="15" type="ORF">Hamer_G017724</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046276">
        <property type="protein sequence ID" value="KAG7153903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JAL4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001607">
        <property type="term" value="F:neuromedin U receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005390">
        <property type="entry name" value="NeuromedU_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01565">
        <property type="entry name" value="NEUROMEDINUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="116"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7153903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="344" mass="37616" checksum="1B037D30881CB3BF" modified="2022-05-25" version="1">MRVRTSRTMEEVNMTSSVVGPQNMTMTTTAESISALSTPSPSTTAASLTTTHVAFFTTFLSTLTPTITTDALTPESNLTNITGGGDDGGHLKPHSMTMIVVMTVIYILITITGVVGNVATCVVIVRNRIMHTATNYYLFSMAISDLLLLSFGMPDDIYLLWWGQPYIFGEEFCFIRGFTAEISTNATILTIAAFTVERYIGICHPLRSHTMSQLGRVIRFIAVIWVVATACAVPIAIQYGIVYEETPDGKQDPSTASCLMKKRIALVFEISSVLFFVAPMLLIMVLYVCIAVQLKKSTRMARSVPSIGSHNYSSTNDGSRNKAVIKMLGEYLSYLTCSTLVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JB02</accession>
    <name>A0A8J5JB02_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Copine-8-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Cpne8-L2</name>
        <name evidence="4" type="ORF">Hamer_G020051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045843">
        <property type="protein sequence ID" value="KAG7153993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JB02"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000099">
        <property type="entry name" value="Copine 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7153993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="513" mass="58037" checksum="2B1CA908E9508DC8" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JD61</accession>
    <name>A0A8J5JD61_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G019671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043654">
        <property type="protein sequence ID" value="KAG7154859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JD61"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="98" mass="11486" checksum="4272F043367002B9" modified="2022-05-25" version="1">MKSCRDCSTLISVAFGQQGQKPSCRLQQQITVQPTQITLVVIKLLFRYLEALNRNLVSSFHDMCESVRGYVMYIFWGLVTMKCEFELELQHPKIIYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEM3</accession>
    <name>A0A8J5JEM3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Axonemal 84 kDa protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">AXP83.9-L</name>
        <name evidence="5" type="ORF">Hamer_G010578</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNAI7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEM3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022110">
        <property type="entry name" value="CASC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031826">
        <property type="entry name" value="IC97/Casc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023247">
        <property type="entry name" value="IC97/Dnai7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20929:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20929">
        <property type="entry name" value="LUNG ADENOMA SUSCEPTIBILITY 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12366">
        <property type="entry name" value="Casc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Casc1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IC97/Casc1 N-terminal" evidence="4">
        <location>
            <begin position="107"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CASC1 C-terminal" evidence="3">
        <location>
            <begin position="402"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7153283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="658" mass="75639" checksum="7D30E204EA57B5D5" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEW7</accession>
    <name>A0A8J5JEW7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FGFR1 oncogene partner-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Fgfr1op-L</name>
        <name evidence="3" type="ORF">Hamer_G020290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038254">
        <property type="protein sequence ID" value="KAG7157007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEW7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034453">
        <property type="term" value="P:microtubule anchoring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018993">
        <property type="entry name" value="FOP_dimerisation-dom_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09398">
        <property type="entry name" value="FOP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGFR1 oncogene partner (FOP) N-terminal dimerisation" evidence="2">
        <location>
            <begin position="32"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7157007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="348" mass="37774" checksum="97B6AA2C6FA22EC2" modified="2022-05-25" version="1">MSIEEEEDASLKELVTKTLHSNGVLGKIQKNIPLVSASAKKLLGTPEGTIAAALVQDFLQCLGLDFSLAVFAPESGHSTSWTFPGTEALTSSLNLNTEKGGQKTPLLIELLRERESNISPVEKKNSQVKCSVNSNRGHYSQLPMLNGMPQPDPSHSGSELFKTKPESSLSNFLDKAGSENSKSFSTTEAEGRSGLSKNGDKDSTKEAELKPRPEIDRASIKLTSQDDKLSSESYQTSQNIGVGDNSNFGNAPSARFPVLSSMEEKNQGSYHTSPTGKEKQYEDDFSSMSDKEDQDEEEEEECVEEVDDIDEDISIDDLINSSASIGSDATKDQSLSQASDVVNYQEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGK1</accession>
    <name>A0A8J5JGK1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G020062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
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            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045843">
        <property type="protein sequence ID" value="KAG7154003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGK1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="65" mass="7157" checksum="8A31EC79BB4C20D1" modified="2022-05-25" version="1">MVFDRSLYDFSCPSAGSTPSASALSGYSYSQGWTTPLGYVQYNLTYFSRGPGRLDLLCYLGTIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGP3</accession>
    <name>A0A8J5JGP3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G029920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045495">
        <property type="protein sequence ID" value="KAG7154078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGP3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035181572" evidence="2">
        <location>
            <begin position="16"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="528" mass="60118" checksum="9F8DE6853A7B2C1D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIC2</accession>
    <name>A0A8J5JIC2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034663">
        <property type="protein sequence ID" value="KAG7158562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIC2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="79" mass="9001" checksum="1978461C5E1D256E" modified="2022-05-25" version="1">MTFNRDVNETPTDRGASDAIDRTRVNGRRNETESPRPTSTSRLGSERRSARSCRRINRSPVAVCLHYLPQDNQCRVQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ91</accession>
    <name>A0A8J5JJ91_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Endonuclease-reverse transcriptase-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G010026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJ91"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33273">
        <property type="entry name" value="DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33273:SF4">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="57"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7157184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="196" mass="21762" checksum="66D0C821D0ED75CC" modified="2022-05-25" version="1">MSKDAQFRLPVPKRPNAHGSMILVRATIPSSEVEPVHCGDGVEAQAVLIHLANDSLVVYNIYKPPPKRLEAGELLTQAIQELVLIVGDFNAHHPTINSTTTMNKDGHHLIELLTDVPEITLINTGEPTYILGGTLDLTFISTELVPVAAQWEVDDELTSDHFATTTLRMELLPPPPRPPPRRNTKKANWKLYQDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJD4</accession>
    <name>A0A8J5JJD4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adhesive plaque matrix protein-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FP1-L9</name>
        <name evidence="2" type="ORF">Hamer_G029719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044906">
        <property type="protein sequence ID" value="KAG7154209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJD4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="239" mass="25860" checksum="FD987C8EF8CED63F" modified="2022-05-25" version="1" fragment="single">MDLEQRRGKVNRDKGDRDPEVEVVPPELNNRDFTATEAEGGHPLPEPECSAPDQNPGFNMMAEVRRTLSTPVSCQLILPTPVTCQLSTYPANPCQLSTYSVNPCQLSTYSANPSAVNLLCQPLPAVNLPYQPLSTYSANSCQLSTYSANSCQLSTYSANSCQLSTYPANSCQLSTYSANPCQLSTYSANSCQLSTYSANSCQLSTYSANTCQLSTYSANTCHSLLLTVPHRHSPALNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JK19</accession>
    <name>A0A8J5JK19_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">NTF2-related export protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Nxt2-L</name>
        <name evidence="7" type="ORF">Hamer_G020315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038254">
        <property type="protein sequence ID" value="KAG7157030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JK19"/>
    <dbReference type="OrthoDB" id="25408at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000006">
        <property type="entry name" value="NTF2-related export protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="6">
        <location>
            <begin position="16"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7157030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="135" mass="15511" checksum="C63B32F7C3332D0F" modified="2022-05-25" version="1">MAAETDRLKLLSACTAAENFTKFYYEYVDKMRHKLAKLYLEDGKLVWNGNPVDGSMNIQKFYEDLPTSIHIITCLDSQPVREEAVGQQSTIQVTTAGFVTFKDRKYPFHQSFLITAKEDKWKVVSDVFRFQAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLP0</accession>
    <name>A0A8J5JLP0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G014866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035946">
        <property type="protein sequence ID" value="KAG7157994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLP0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="130" mass="14884" checksum="8787B65411AD9904" modified="2022-05-25" version="1">MESTRSKTEVWLIGQHITEIKGAQLPSRGDVLRLFFHGHNEHKKTVNDSASEVAASVISFWNKARIPTITEKSIGRKVVDLFLMWKGLKKNCTLTTDTQRKKEETFCDELEDLFDVAHPKAMQLLTIKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLV3</accession>
    <name>A0A8J5JLV3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030995">
        <property type="protein sequence ID" value="KAG7160682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLV3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="700" mass="80033" checksum="E1E6A08ECFEA8D16" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JM73</accession>
    <name>A0A8J5JM73_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Kelch-like protein 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Klhl12-L</name>
        <name evidence="15" type="ORF">Hamer_G020684</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035785">
        <property type="protein sequence ID" value="KAG7158080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="13">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="959"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="987"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1018"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1045"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1075"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="307"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1123"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1234"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1254"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7158080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1296" mass="146801" checksum="525374D45B1F3153" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMI3</accession>
    <name>A0A8J5JMI3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040280">
        <property type="protein sequence ID" value="KAG7155829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMI3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="7738" checksum="38EF7366CE9FD58C" modified="2022-05-25" version="1">MTQQPCTLQGCLYKTPELFETGHPSGLDAPGKHAPASNNHYSAIRDHDRKNRTSEGHVTWANGPPTSPLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JN28</accession>
    <name>A0A8J5JN28_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ionotropic receptor 21a-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Ir21a-L12</name>
        <name evidence="15" type="ORF">Hamer_G014008</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JN28"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035184483" evidence="13">
        <location>
            <begin position="24"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="279"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7161372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="626" mass="70836" checksum="57CDE7B3AB9F9DED" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPL0</accession>
    <name>A0A8J5JPL0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dephospho-CoA kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dcakd-L</name>
        <name evidence="6" type="ORF">Hamer_G019456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035076">
        <property type="protein sequence ID" value="KAG7158443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPL0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000485">
        <property type="entry name" value="Dephospho-CoA kinase CAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7158443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="225" mass="25588" checksum="C706FF291D2F8195" modified="2022-05-25" version="1">MFLVGLTGGIGTGKSTVSAMIQEMGVPVIDADLIARQIVEPGKKAWKKIRETFGDEMFLESGELDRPKLSSLVFTDAEKRKTINKITHPEIYGEIRRQVFRYFLKGEQFVVLDLPLLFESNKVTSYLYKTITQLERLMDRNQYTEKEAISRIEAQMPLEKKCNMADIIIENSGSLSNTRKQVEGIIKLVRTSNHHIYNRVVYGGGFMAVLVAILYLLIFHVIGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ55</accession>
    <name>A0A8J5JQ55_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G019327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028140">
        <property type="protein sequence ID" value="KAG7162030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQ55"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="316" mass="35257" checksum="4D0A34127A7397A9" modified="2022-05-25" version="1">MALPPSHLLFLKYHSSTPHCSTSHFCTPHFSSLHSSLLFSPLLYSSHHPTYFKKLSVMMRYGFLLLLALSPAVLGYGVPRKPVVEQKHEPVIFPTEPLTQEPKGCPTNIIEKLVITTEVVPSYVTVTKDNYVTTTLHNTVYETLTSTVINDIIETVYNTETITNFETNFVTETEHLTDTVISTLTEHSTIVTTVVSDNFITETAFKTEITTNYQTEYLTETQYQTETISTTIVDLQTTSLYITNVESVTNTVTESVPHYVTTTSQVEKLVTITKECYTPSPIKLRALSPSTDGGAVHLMSSVDVDGSFSHNGDFQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQH9</accession>
    <name>A0A8J5JQH9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SKA complex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Spindle and kinetochore-associated protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SKA1-L</name>
        <name evidence="6" type="ORF">Hamer_G008136</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQH9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000940">
        <property type="term" value="C:outer kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1890:FF:000002">
        <property type="entry name" value="Spindle and kinetochore-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1890">
        <property type="entry name" value="Ska1 microtubule binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009829">
        <property type="entry name" value="SKA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042031">
        <property type="entry name" value="SKA1_MBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28573">
        <property type="entry name" value="SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28573:SF1">
        <property type="entry name" value="SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07160">
        <property type="entry name" value="SKA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7162572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="208" mass="23728" checksum="FEBD8B7D5891C37D" modified="2022-05-25" version="1">MATAQKDIVTAHCLLEQMQQLSKRLTHMKTNLPVHIPNVNASPPVVPAAVSQPTTKQTNINKQNEQTYTQEKSKVKTGSGKAKQIPIIEYVTIEEFESVPKYIRGRLQYDQVNNTVNAINKTLESKYTLMARPRSKISEVDMRIVTACRRQENQETRDLHFVVDDDIKRWGNMKLDTAGRSLMTVLRTLKRLREVRGPGNLVRFAVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JR06</accession>
    <name>A0A8J5JR06_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027115">
        <property type="protein sequence ID" value="KAG7162737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JR06"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9852" checksum="D2597293B1965AD8" modified="2022-05-25" version="1">MKLWRFSHNVRDTVRLCVKRYEEEGHVLTRPRTGRPRVTTPAAYQQIQRAAERAPLSTAVLITRETGVQCHPKTTRRRIRETGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JS43</accession>
    <name>A0A8J5JS43_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Vitellogenin-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">vit-L10</name>
        <name evidence="1" type="ORF">Hamer_G008815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JS43"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="236" mass="27454" checksum="3B9371EBB8070C14" modified="2022-05-25" version="1" fragment="single">MKPEQVPVCTGVKIKAVALTSVLGTYDIIFRIGKPAFVELTTRKHNSEKVYTTKFDFQTPKNTEISMHVYDKGTQEQQAIIMARVRPFSPGMAEVDLVYRREEIGRLEVVLSEAIDRVLVSSVSWCKRVYEQVVQEAHQKNITFPPKEMNKLVEQVLVDVRMIYRDLNVDVFTPASEALCRIVESRAVSYTLEVSHHAWLLLRWIQQQLPKQEVRPYQEHINLKEEIEDLNWLIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSC3</accession>
    <name>A0A8J5JSC3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSC3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="515" mass="57560" checksum="E2164398C06DC14E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSD7</accession>
    <name>A0A8J5JSD7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Synaptotagmin-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SYT3-L</name>
        <name evidence="3" type="ORF">Hamer_G012695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSD7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00276">
        <property type="entry name" value="C2B_Synaptotagmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="62"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7160154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="347" mass="38228" checksum="133CE77865C611AE" modified="2022-05-25" version="1">MSPIHGASTETNSLLGALSSKRDSTYSSMSEYSGRTSPTNSCRSSVGDSVGSGVGSPVGGEAQGHLSFGVQYVVTSPESNTGKLVITVLEARGLTGREYLGNACDPYVKVVVWKERRSLRKQKSPPLHVFRTRTVRHTQDPTFNQSFVIEAAKSDLKELVVKLVAMDSDKWASPSTDLGEVLFGLSYLPTAQRLSVSVIKAQNLKHTNVVDDLKDFCRVIKKKKTTWRSNTASPIWNETLIFDLAQSQVEHVTFLLVVCTRPQLPVTPTNSDASLQSTETFHDNSLSLAPPDLNSSSLHDQNQNKKQDRYVGKLALGCNVRSNDQRQHWMAIMASPRKVVSQWHGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUW6</accession>
    <name>A0A8J5JUW6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane frizzled-related protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Mfrp-L2</name>
        <name evidence="6" type="ORF">Hamer_G025219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033087">
        <property type="protein sequence ID" value="KAG7159639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUW6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="140"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7159639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="254" mass="28650" checksum="3127F7535A5F0C43" modified="2022-05-25" version="1">MSFRRFEGRVEERTGVYQDEVNNYQTHVESTTTQINAVDTAQNNSIEEMKEELRRLQDVHEEEVNSLKSHINALSTLINNSVETINEVLASRIDHQQEEASSSRSQINSLTTQMRSMERKVELNSALLVNETNITSVSTCTGDKVLTKPSGYLAVVDSGLYPTSEDCGWEVKLPEDNDISLEWLFMSVEEQATCVFDYVTVENLNEPGQLLYGGKICGSSLPAMMKTGSNHLRISFHSDGSYVFRGFKLFYHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV37</accession>
    <name>A0A8J5JV37_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Proteasome subunit alpha type-2-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Psma2-L8</name>
        <name evidence="2" type="ORF">Hamer_G007872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JV37"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035146412" evidence="1">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="129" mass="13886" checksum="7B1412684876A547" modified="2022-05-25" version="1" fragment="single">VVMLLGCHIMVVVVVVSAVPKAVQEVSGSMEQVGVDVGVMMSQVLEHHLTGCHLVLVTTTLHLYVSTSVIRHMGVRVEAGVAVEAGWMLSQDQLTQDHLLQGLWGDIRTTCRALILDLTANNSADSVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVY6</accession>
    <name>A0A8J5JVY6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Single domain von Willebrand factor type C-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G007330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVY6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029277">
        <property type="entry name" value="SVWC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15430">
        <property type="entry name" value="SVWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01318">
        <property type="entry name" value="SVWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035302029" evidence="3">
        <location>
            <begin position="24"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Single" evidence="4">
        <location>
            <begin position="225"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7165482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="298" mass="33692" checksum="09DF17D01AFB0AB2" modified="2022-05-25" version="1">MVRGLRIFLWVATLSATLTPVFCAVAIEYANNPEILPKISEVVIDLLIKEPGSREVKGYPYFWAEIWLLSKIIEEVILNLLKDPLEDFWSKKGILSVMPAKVILYLLIEDPAFRKPLEEFGDEQKFTKNLIRCCPQPFNQGSMVHRCQEIPLDLLIKYIGPEGFQAEKWILPKILAAVILNLLIKDPGFGGQKLFFPYLHSPEMPSLMGKFTKIQNIRPDMPGNCLLKESRISVPSGTTWELPDQCVRVSCGGKGSNMYIRYTGCGLVDAQFPCSIVQDMSKPHPKCCPDIFCPKTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVZ0</accession>
    <name>A0A8J5JVZ0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Adhesive plaque matrix protein-like 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FP1-L19</name>
        <name evidence="2" type="ORF">Hamer_G024878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027973">
        <property type="protein sequence ID" value="KAG7162254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVZ0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035190294" evidence="1">
        <location>
            <begin position="28"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="193" mass="22839" checksum="DD3BBFC7DB5DA595" modified="2022-05-25" version="1">MTTMTSGMARLVVVVLVAVAAVVVAEADYPAPCYPETLYVTQYQTQVQQVPVYETVYKQQYIPTTLYHTHHHTQHLTRHHTQYVPQYVTKTVYKTHAQYVTKYKTIYHTDYQTQYATKIQYVPTYITKTQYQTQYRTQVQYQPVYETIYKPKYITTTYVQYHTQYQTQLVPVYHTVTKAHKTYKTVCPKPAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWJ1</accession>
    <name>A0A8J5JWJ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trypsin-1-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Tryp1-L6</name>
        <name evidence="7" type="ORF">Hamer_G013083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024020">
        <property type="protein sequence ID" value="KAG7165585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWJ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF18">
        <property type="entry name" value="OVOCHYMASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035314953" evidence="5">
        <location>
            <begin position="17"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="32"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="298"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7165585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="535" mass="58245" checksum="88DA31C3119C59BE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWM1</accession>
    <name>A0A8J5JWM1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aster-B-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Gramd1b-L2</name>
        <name evidence="3" type="ORF">Hamer_G002746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWM1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRAM" evidence="2">
        <location>
            <begin position="283"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7163548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="421" mass="45373" checksum="4B353C19F5ED3BC4" modified="2022-05-25" version="1">MEADDGGGVREVSSNPNRLVSSVSAYPLPNTNTVSAGIINATPAAAATASAASTFTISSTSSSSSTSTNSSSHSNIQQQLPSGMVNTSCPNTEYTTSGYLHHGSDASSSTSPNTVTSTGDINNAQCNSIGGNNPLDLSGIPPITQVTLPTPTENGEGRFSKSPTPSPKPSPTLMIRQTSCDSSDDRANKNDTCSFISREGSMERSFTEASAEHQPIEKLLDSTSRSSESSRSVEAPRTPEIGTNFNGVLIKERKESRDSKSGDKKSNKAWYKMLNPTYKSRSEDLKRLFKDLPSDERLIVDYSCALQKDILVHGRLYVTPNYFCFYSKIFGWETFQMSATELWQWVHSSYGDELGLTSDDDDYVAPSTEDDTKTSINHGHNDRTCDSSSLNTSLKLYSGDSLEAGGRSPHLDISVLGCQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWU1</accession>
    <name>A0A8J5JWU1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030642">
        <property type="protein sequence ID" value="KAG7160809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWU1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="263" mass="30088" checksum="CBE68DC6D9A54C06" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSIGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDSSSDEQEATSDDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWY8</accession>
    <name>A0A8J5JWY8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023205">
        <property type="protein sequence ID" value="KAG7165870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWY8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="251" mass="28908" checksum="CCB95AA02354D8DB" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKPTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQITNTKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNVTKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXJ7</accession>
    <name>A0A8J5JXJ7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein 60A-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">60a-L1</name>
        <name evidence="8" type="ORF">Hamer_G002028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7162988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXJ7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF119">
        <property type="entry name" value="TGF-BETA FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0339">Growth factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="7">
        <location>
            <begin position="194"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7162988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="327" mass="37068" checksum="553BEA31986858BD" modified="2022-05-25" version="1">MTGWEPRGAAYQASVHSAKDKYRCVLYTNEVFVLQDKYRTSTGGRRSTGVEGQVVHFHVAVPIRRVYHHDNDVKKATCRLWKTGGPAPQDPAHNTVTVTLYQINNLSRRRRRRKQDVVLMQALNVSVTGDEWLTVNVTEAVREWLKTPRDDAGVLVQCPDCGAAGVTIHTGVNTSNTTYVPTLDVQTQVPAGRRVKRSPELTRATKAKWRRHGDCRDMSPNGRRRRSRCCRRSMKVRFKDLPDFDFVESPDNFDAFYCSGKCPPRFNPANEHALLQSLLKLKHKKRIPRPCCAPTALKGLHILHLNDQGTLTTTYWDDMIVTECGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZI0</accession>
    <name>A0A8J5JZI0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine protease HTRA1B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">htra1b-L</name>
        <name evidence="6" type="ORF">Hamer_G005048</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZI0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005520">
        <property type="term" value="F:insulin-like growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000867">
        <property type="entry name" value="IGFBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011390">
        <property type="entry name" value="IGFBP_rP_mac25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14186">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14186:SF19">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00219">
        <property type="entry name" value="IGFBP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51323">
        <property type="entry name" value="IGFBP_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="IGFBP N-terminal" evidence="5">
        <location>
            <begin position="64"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7164658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="156" mass="16927" checksum="A820EF7D9DC73099" modified="2022-05-25" version="1">MSKKVGRVEVCVGLTSYRRWGGGHRASTAWGWGLPESSGPRLVILQPNNSRFFLLGIPGSGSMRCQECRDCDLSECYPLTSSDCLWGIHKDSCFCCNRCAKGLGESCGGRLEEFGKCGPGMGCTSQDPEGEGVCSMALLMPKTVPIIFHPQKKTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZS9</accession>
    <name>A0A8J5JZS9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G005332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZS9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="272" mass="29953" checksum="18121D9438C4AE16" modified="2022-05-25" version="1" fragment="single">NFEYEEETPKEVKVEYYYESFTEPTNSTPAIIVPPTMAPATTESTTTESTTTTESTTTTESTTTTESTTITESTTTTESTTTTESTTTTVPPVIYKKEILSCNGYTLDDITWKHNGNLVFLGTLDVGGIADLSLSSDGALVLAEGPNKNIRDNDTYICYIETDVTDVAVATYHISLSGEDTFIKTSIHNTEETPDIELLSIPLPELQFLELKEEEVAILTNTERVGKRILEVLEKGGLNVKNVIKNDYLVTLQLNQSVFIGIDFFVEIAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0I1</accession>
    <name>A0A8J5K0I1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat-containing G-protein coupled receptor 4-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Lgr4-L1</name>
        <name evidence="3" type="ORF">Hamer_G010257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0I1"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035161113" evidence="2">
        <location>
            <begin position="26"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7167852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="452" mass="49511" checksum="DC78890AAB32FDFD" modified="2022-05-25" version="1">MMADYTGIWWRVMALILALSVMTSAQRTKSCDVQGSVAASNKVDVHCDCMQRLTQMNLAIAHLTINQTSCSNSGLELRWPDLEALVSPDTFTVVGAHIYFSQSQPNTTWNSSISRLYFIDSTFEMLPAHAFRGMGLLEEVKFFGGSIVTIRSNAFSGLQKLKLIEIANSTVETIEREAFNNLESLEDLAFVHTSIGIIESEAVSLLKQNKAEVRCVTLGTRPSGSGSVIQDLMGRQLTSTGNISLPEYGSRLLLLKNNIKTLKSRAITSETLGFLIVGGNHIENVESLAFSMELYNECEISAALFVGNTFNYLGNSALAGLKGRDGVSYQTFIALAQNTFLNVTQQGFLLSQNLVIFTVDENKFRCVCDGFNWILSNPDSQNQQELEKELVLKATCIDGTYLISYTSSCTDHGTVTTPSARPPVMETSGASTMSFFSVSTSVITFVLARTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2F7</accession>
    <name>A0A8J5K2F7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Killer cell lectin-like receptor subfamily B member 1B allele A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Klrb1b-L</name>
        <name evidence="3" type="ORF">Hamer_G021579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018031">
        <property type="protein sequence ID" value="KAG7169187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2F7"/>
    <dbReference type="OrthoDB" id="6359822at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035209198" evidence="1">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="45"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7169187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="176" mass="20098" checksum="4F50E84F5979F029" modified="2022-05-25" version="1">MQAAVLVLYLAVVGCIAAKKVGKISEDHEADSREKLECSNGFLPIAGNCYRFFQEKKSWGDAQMRCQNQNTNLASIRDKQQYQGLLAHISAHFPGTYWTSGKLESGQWIWTATGTSMSQKWWGTNPSNSSNHCAYLCSYTSKYWDESCDTERNFICEKAQEPLERSSKYLYAYRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2U4</accession>
    <name>A0A8J5K2U4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7165880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2U4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="256" mass="27811" checksum="EA296568E48D05DC" modified="2022-05-25" version="1" fragment="single">SHNTAPHNTAYHNTDSHKKAPYNTASHKTASHNTVTHNTASHNTAPQKQLHITQPPHNTAADNTAPRNTASHNTAAHNTPSHNKSSYNTASHNRAPHNTAAHKTPHITQTHGTQTHITQLHIKQPHITQPHITLLHIILPHNITSHNIAPHNTAPHNTASHSTATHNTAPYNTAPYNTASHNTPHNIASHYTAPHKRAPHNIASHNTAHLTELLHNTIIYSPKTAPHNTASHRTAPRTTASHNTASNNTAPHNTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2Z7</accession>
    <name>A0A8J5K2Z7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retinol dehydrogenase 14-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RDH14-L</name>
        <name evidence="2" type="ORF">Hamer_G017203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2Z7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF66">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="270" mass="29586" checksum="8E78B62EF01ED1BA" modified="2022-05-25" version="1">MWIEVLVTVVAVLFGLRILYRKTSGRCHSQRSLTGKTAIVTGGSAGLGKFTAKDLVRRGARVILACRNLEKACKVAAWIREAEGSVGEVVVRELDTSDLASVRQFANEILLTEKSLHILVNNAGIIGFKDKRMTKDDLELTMATNHYGHFLLTNLLLGNHWFIKSLDVTSAALNFKTEPYNRIRAYGKSKVCNILFTLELASKLSGTGVTANSLHPGVIHTDLINPHPLILLTGRGGTQTTIHLAVSEEVKRVRKILRGLQGGKDIGFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K327</accession>
    <name>A0A8J5K327_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022339">
        <property type="protein sequence ID" value="KAG7166593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K327"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053729">
        <property type="entry name" value="MAD2L1BP_domain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="392" mass="43241" checksum="2222422359CE8604" modified="2022-05-25" version="1" fragment="single">MPRVAIYPRVAIYSTVATYTHTTEATHPTVATYTHPTEATHPTVATYTHTTEATHPTVATYTHTTEATHPTVATYTHTTEATHPTVATYTHPTEATHPTVATYTHTTEATHPTVATYTHTTEATHPTVATYTPNRGHTPNSGHNTKQLTISHILSSGCGAGGLAVVQEVWRWCRRWWRRCGGGAGGVAVVEMRNQIPVQFGALVREVAKTEDTTSHHGEAPTQQEHTANKVYSRKEEIARCTLRSKRQRWLTKVNNCLEDFNIIMQTLRTELNDGHVMAVNVILGSSIISGQEVFSIIFPRDCSSAPAECEVSNGRQTVMQFFRPTLESPINASKRIEPIVETPTVSSYVCENQFTPSKFLTTQLGKFTHSESCLEDAGCGGDNVAWYQIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4A1</accession>
    <name>A0A8J5K4A1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017989">
        <property type="protein sequence ID" value="KAG7169201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4A1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="242" mass="26862" checksum="FE43BCD2C2B29B0A" modified="2022-05-25" version="1" fragment="single">MESTRSKTEVLLIGQHITEITGAQLPSRGDVLHLFFHGHNEHKKTVNDSASEVAASVISFWNKARIPTITEKSIGRKVVDLFLMWKGLKKNCTRTTDTQRKKEETFCDELEDLFDVAHPKAMQLLTIKEDRAFLAAQREKGRRGVMAGVDKKIACSIKRREESKSKQSLQQNQASSALEYDELGSSSETESQSSSSSSTSSLAISPVVSSSNRKRATLKVITPELSSTLDRTGISHRSALRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5I6</accession>
    <name>A0A8J5K5I6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclear pore complex protein Nup205-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NUP205-L</name>
        <name evidence="6" type="ORF">Hamer_G012884</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7167425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1900" mass="208463" checksum="A6BF6DDA78449218" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8G7</accession>
    <name>A0A8J5K8G7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Pzh1-L1</name>
        <name evidence="3" type="ORF">Hamer_G028014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010017109">
        <property type="protein sequence ID" value="KAG7169364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8G7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF496">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="2">
        <location>
            <begin position="271"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7169364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="303" mass="33996" checksum="248D6D162810C561" modified="2022-05-25" version="1" fragment="single">KDGSSRNKRLQSPVRSLVSSGLECPASAGLQNKKLKKNHIMDYKNDLFSVGVSENAPVSNIGNDSQDVAGSIPLSARALVTPASNTYTLAHRTVKARRSGQITDIRLLHDMERDGEVCDTGFRADGVRHRVCDAFESVKAFIRNSLPNEMFTALRYFEHERNDKAPLHWGEVDMTKLAHFISSLCSSVKDLFENEARLLRLASPCYIVGDLHGNYRDLICFEKVLWREGPGLTPANFLFLGDYVDRGDYGIEVVSYPFSQKLLNPTTFFLLRGNHEVREILKAFTFQKTTRSECLLASAMTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJF3</accession>
    <name>A0A8J5MJF3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046918">
        <property type="protein sequence ID" value="KAG7153442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJF3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="133" mass="14910" checksum="A45053A8EF1CC03D" modified="2022-05-25" version="1" fragment="single">MSPSLTPTPHYKSFPHSYTALQVLPSLIHNPICPSLTPTQHCKSIPHFYTILQVLPSLIQSSPSLTSTPYYKSFSHSYTTLQVLPSLIHNTTSPSLTPTPHYKSFTHSYITLQVLLSLLHDPIYPSLTPTPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK18</accession>
    <name>A0A8J5MK18_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glass-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gl-L4</name>
        <name evidence="1" type="ORF">Hamer_G022137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044612">
        <property type="protein sequence ID" value="KAG7154294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MK18"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="224" mass="24031" checksum="5646DFFC011A1E67" modified="2022-05-25" version="1" fragment="single">TLPSMMGSMSAGSCYATGSYQDAASAYSSPAPPHVFPAMSVNVSMNMTMGVSNVNMGYSPEQSLQHQWSTSCSGPQGSSISPVGGVGYPQHSAPGLVSPLPMSYSITITLLPTQPPSLSLSVSGSCSQGYGVGSYSWSGDLRPDHHTMPSFDRDLCLRSPPIRPRPGSPCIPPYHNTTPTSQSPFSPHWLLHVVSFRRAIITYAERLTKTTQCRGRDDHVQRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK62</accession>
    <name>A0A8J5MK62_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044460">
        <property type="protein sequence ID" value="KAG7154493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MK62"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="197" mass="22091" checksum="DE9E0861B0376106" modified="2022-05-25" version="1" fragment="single">MSMGRNLRAARCLDFTDKDDDDGLYQPSDSDTEATKKKGETVDEENNNTTSGNNIKAKHRRGTVSGIIGALGGSTTSAGGVLRRTSVSVKRPLDIVLPCQEIQYLDISYQKVGRVMLLIPQVQYSPIPRKKIAYHHVPYNPIPYCEVPYCGTGERPIKRKPLQRSHSIAIADLREPEDCEWTSYKLRYISFSQTLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKD7</accession>
    <name>A0A8J5MKD7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase/reductase SDR family member 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">DHRS4-L</name>
        <name evidence="2" type="ORF">Hamer_G014988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKD7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43943">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE (SDR FAMILY) MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43943:SF2">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="153" mass="16131" checksum="7ADBB88F0F29224C" modified="2022-05-25" version="1" fragment="single">TLEKFGGIDILVSNAAVNPTIGGVLDCPETAWDKIFEVNVKNALQLSQLVVPHMQQRGGGSIVYVSSVAGFQPFNVAPDNIRVNCVAPGIVNTKFSSVLIENPAAAEKLQENILLGRFAEPKEMAGLVSFLCSSDASYITGETIVVAGGLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMB4</accession>
    <name>A0A8J5MMB4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Transposable element Tc1 transposase-like 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tc1a-L29</name>
        <name evidence="5" type="ORF">Hamer_G006184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMB4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="4">
        <location>
            <begin position="42"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Transposase Tc1-like" evidence="3">
        <location>
            <begin position="103"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7156427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="223" mass="25516" checksum="A2F09B228F9E7C0E" modified="2022-05-25" version="1" fragment="single">MGAVCKLLSRGLVVFLRFVLCFCLNISVMGSGTELGRDTIVAIITLYKEGYKCKDIATRVGIGVRQVQKWIKKFRDGGGEDILTPKPRSGRPRKIQNRTSKVIKRQLDKNPTLTARKLKENNPALLQDVSVRCISDHLLKDLQYRSCCAKVLPLLSAKNVRDRIAFSKKYKDWTLEDWEQVLWSDESTFVVSSGCRSKRKNWQDASHNVWRRSSSLEENRLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MML3</accession>
    <name>A0A8J5MML3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038254">
        <property type="protein sequence ID" value="KAG7157011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MML3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="108" mass="11823" checksum="694C54DB8A432EF8" modified="2022-05-25" version="1">MTLCNAKVKRPSFNLAVWSDRQGYQARLLLHTFTSRGAEGKKGKNHSYHPLRNKKKPTISTESSASQPESKGKTIFRTSAAGGREGILTSSLNRPTAYRSGVPGIPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNC4</accession>
    <name>A0A8J5MNC4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tigger transposable element-derived protein 1-like 142</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TIGD1-L142</name>
        <name evidence="2" type="ORF">Hamer_G018835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036987">
        <property type="protein sequence ID" value="KAG7157759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNC4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="297" mass="33157" checksum="5D41E492C2870B34" modified="2022-05-25" version="1">MTWKEVTVRCLCAAWRPLWPECVLQRDFEGFEESEEEAVVHEIVALGNSMGLEVDDDDVEELVEEHSKELSTEELLELHKEENETLKRSLTSEESGEEEDKEESRIIPAKDLKDAFFCWSKLSKLAEDYHPDVGSVQKAISVFNDNVMNYFWKVQKSSVKFPLTTPNPQTQTSPPNPQTQTSPPNPQTQTSPPNPNIVTEPSTPNSRGGRGAGAAGGAGCAGLFGSRMFPHCARQTLSRKISSRPNLERSSKQLTFKVWHCAPEEVQVHSVQGVGVRVSPMPTAWLPMTQVLESRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNG7</accession>
    <name>A0A8J5MNG7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036054">
        <property type="protein sequence ID" value="KAG7157941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNG7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="550" mass="63181" checksum="D0CA498C6321F27E" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNY1</accession>
    <name>A0A8J5MNY1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hemocyanin B chain-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HcyB-L3</name>
        <name evidence="4" type="ORF">Hamer_G014916</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tyrosinase family. Hemocyanin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035946">
        <property type="protein sequence ID" value="KAG7158032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNY1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF5">
        <property type="entry name" value="FAT-BODY PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00209">
        <property type="entry name" value="HEMOCYANIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7158032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="655" mass="75498" checksum="BFB390E690A716A0" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MP95</accession>
    <name>A0A8J5MP95_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G029690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035345">
        <property type="protein sequence ID" value="KAG7158392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MP95"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="70" mass="7884" checksum="555F8A1E82D4F207" modified="2022-05-25" version="1" fragment="single">GFFLEVIGLTGGCLFVQWFQESGSLGENLGPRTWSRDIRCCAVLLQDQTSPPVSSTTYYRNIKIHHMYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPA2</accession>
    <name>A0A8J5MPA2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035124">
        <property type="protein sequence ID" value="KAG7158422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPA2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="49" mass="5571" checksum="ABBA4251227586C7" modified="2022-05-25" version="1">MKTRRKAASFQPKISRMCSGAGANCLSVWRIIIVMLVLWKRASVFLMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQB2</accession>
    <name>A0A8J5MQB2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription elongation factor SPT5-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Spt5-L6</name>
        <name evidence="2" type="ORF">Hamer_G024077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032181">
        <property type="protein sequence ID" value="KAG7159784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQB2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="901" mass="95883" checksum="819912B46F2782B2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQS4</accession>
    <name>A0A8J5MQS4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Hamer_G001574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQS4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7160355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="306" mass="34230" checksum="DAC91F4439CE5378" modified="2022-05-25" version="1">MAEPVLFLHYAADCTQFIITENLRLDRFCQVTLNKTAEECAVMNDKYHTDLQLCDSDEVGRYMSLLAIIQVLWPLVDSAIFTAIYTSTLSFYPSYEHLVAAVFSFYALCGFLGLRLSLASEERRPPTLPEQGVSPSVPEDKEEHLTQTSSQHSVSPNYQDHNSSPVDLKATYSSVRSLDPSQSEDTRFSGGSSSRVDDISEKLEFWTIKRGQPVLCDNDEVGRYMSLLAILEVLWPLMDSAIFTAVYTSTLSFYPSYEHLVAAVFSSYVFSGFLGLRLSLAIEEGRPPTLPEQGVSSSVPEDKEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQX5</accession>
    <name>A0A8J5MQX5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQX5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="121" mass="13529" checksum="09630B335FD4CDE1" modified="2022-05-25" version="1">MALGLEQAKQEDHGSEEVQLCLVTPTPKVQCSGRKWTNALDGSDRCSIDFRGIEFLEEDICQNVIPSPKVPAVEVEFLGKESSMKNWPVDELTLLTEIMKNNIPWRQGNEETGTKVSFSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MS87</accession>
    <name>A0A8J5MS87_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Cnot11-L</name>
        <name evidence="10" type="ORF">Hamer_G014166</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MS87"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7161602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="441" mass="49459" checksum="247222A457D25E37" modified="2022-05-25" version="1">MSPCSALETFWISDDSTHVGQRILSEESADSSTLEQITHQIFQNFTKEDYFKLGSALVFLLQQPDLLPSPAQRLSAITILHELYRGEPPPNNPFLPIFVNILHPPDDVAKGTGKKLEYAGQLPKISPPEIVFLSTLITDKNSKELLKRTAAQIMSLDVTNHPPIDTTALRLSLAELLAERPDIAKSAVPIVYSHPQPSPSSGLLSEVGQVKRTCEALLCGPVPTLAQQYFTPEIIRLTPPLHIAEDELVWITSVDRAEYKIMYDSSMCVLSGGDAEAKRLMAKAFKETLSLPQQQHLLAELDKDPRMVYHTGLTPPKSSQITEYFSVLVNMEMSLHSMEVVNRLTTAVELPSEFVHLYISNCISTCETIKDRYMQNRLVRLVCVFLQSLIRNKIINVQELFIEVQAFCIEFSRIREAAALFRLLKQLDSGDTQTTQEPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSC2</accession>
    <name>A0A8J5MSC2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Proteasome subunit alpha type-2-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Psma2-L6</name>
        <name evidence="2" type="ORF">Hamer_G007866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSC2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035320760" evidence="1">
        <location>
            <begin position="25"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="187" mass="20749" checksum="A2AA8C1654F9DF83" modified="2022-05-25" version="1">MMASLGHRLLVLAGTVMTISSVASQDMVGPVEQVGVMVGQVVEHHLTDCHLVLMTTTQHSHVFSSIIRLAEVAGLWKMPETRVVVVGRMAGVKDVLLHHSLRNTVHGLYLALHDLTLHTPPRIGSSRLRKALPREGFTLDVYPYDMKKLLSLSDHYHLTTLDNVHASLLIIIFSPCVLRTDSLPNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSC5</accession>
    <name>A0A8J5MSC5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RYamide receptor-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RYa-R-L2</name>
        <name evidence="13" type="ORF">Hamer_G014115</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSC5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF73">
        <property type="entry name" value="RYAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="88"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7161556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="360" mass="41308" checksum="AB8FE631F3D66E99" modified="2022-05-25" version="1">MATLDYRMNNFLALEEGARNESDYILYLCSPNDSTSIHLKLEFACDYCNESEVVVLWDKGVCDFPPTPGFNTSIYVFYIAILVFAVLGNSIVVYVVCSSAKMRTVTNYFIANLAVGDLWMAIFCVPFSFMSTLILKYWPFGGHLCVAVNYLQAVSVFVSAYTLVAISLDRYLAIIYPLRPRMTRFQAKMIIAMVWILSLVTTLPVAIYSKLLTPNFNFYKLFSRQVCMEDWGESQAENESRMAYSVALMLLQYFLPLAVLIFTYSRIAMVVWGKKNLGETPARMDRIARSKRKVRCYARFQIGVSVSSQIHHKAKYLFQMRQILVPCIYCGLLLNIWNPNQILFILQEKVDLVKLKKNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSF3</accession>
    <name>A0A8J5MSF3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative variant ionotropic glutamate receptor-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">viGluR-L8</name>
        <name evidence="1" type="ORF">Hamer_G007980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSF3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="113" mass="12982" checksum="1C739D29726D9A9D" modified="2022-05-25" version="1">MVVVASNDPTFLTAYAQKSLKGRLLVWETRQLLVTSYTSRELRAALTSHWTFSMTNTMLMNVEYGFHMLRCGVYVYLPYSPRGAKVVEVAYWTFPQGLVYIASLPLFPEKFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MT08</accession>
    <name>A0A8J5MT08_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger protein 513-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Znf513-L8</name>
        <name evidence="7" type="ORF">Hamer_G018299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027102">
        <property type="protein sequence ID" value="KAG7162773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MT08"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7162773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="74" mass="8736" checksum="E677E0E33314E293" modified="2022-05-25" version="1">MESRGEKSVAGVKTFKTHQCQYCSYSTYFHYLLVRHTRTHTGERPYSCPHCPYRSSRKDYLKHHINTHASVTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MT65</accession>
    <name>A0A8J5MT65_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Chst11-L4</name>
        <name evidence="11" type="ORF">Hamer_G008020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MT65"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF63">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7162471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="380" mass="44916" checksum="9FED8D09843837E8" modified="2022-05-25" version="1">MLFIKYRRVWWRVKTVLVILLTVVIVSLTFVSLASIISHHYWVVVMMQRMAERTKLVDHTCHKYSNFLLQQYAGSLNADPTRWSTVNKTLLANPDVLVDRQHRLAWCKVPKVASTSLVHGLLRVLGQEHLINEIPRGQLHTRLRHLMPHPALQEDVSFCTTFMVVRHPFQRILSAYRDKLQNKWEYHQFKKFRDLYGMPIIQHYRNKPQPPEYIDVPTFWEFVEYLVSTPASDYNEHWRPYYLVCTPCHHHYSVILHLEAMDEETQYLVHITNLEGLKPLYVHTTNLSGPIPHFHKVPDNHRAKTHDHIHSKKASSGNLDRMTHSKRDQDHKSAQNIEALLFSQIDRTQLVKLYEIYKVDFEMFGYDLSPYNTYVNATSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTF6</accession>
    <name>A0A8J5MTF6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027066">
        <property type="protein sequence ID" value="KAG7162801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTF6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="247" mass="28350" checksum="7B4ADAA1593A4C9B" modified="2022-05-25" version="1" fragment="single">PLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLSSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTH9</accession>
    <name>A0A8J5MTH9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTH9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="228" mass="25692" checksum="60BADBB1F3B28F54" modified="2022-05-25" version="1">MTNGRVVRLTVVPCAVPVGSLLMGYTAITHPLIYQKLLCDLLVARDRCFGHHLFRLIVRSSTIFPHLHGRPARAGQVFQEAVILWRESSYRRYETTPSNLYKRQNTDDATINKRRGDVTMSSPSTRSNSSCHLSNLVGPGRQLLVSELPTFRDLLWLGLLKRKGSDADRRNYKVKDLNLMNQASVGIGPTETHQPPLESPSITIPPLPPPTIHHTDHITFLHNAHGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTK9</accession>
    <name>A0A8J5MTK9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sodium/potassium/calcium exchanger Nckx30C-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Nckx30C-L2</name>
        <name evidence="2" type="ORF">Hamer_G002676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTK9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="145" mass="15773" checksum="73870628BCC31F30" modified="2022-05-25" version="1">MGKVDEKATQLHAIASLKVLLDATKPQNGRVETYRSDGLAPDPRPDNQSHPNGSVLEEITLTNAHPLISMAAIRDAAVWDDIEPENALTPVETLPHGDKLNGAQQQSWTTSNSDAVTDTGVMPHDWLEGSGDAGVERWWHGRHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTL2</accession>
    <name>A0A8J5MTL2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7162937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTL2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="73" mass="8485" checksum="C1D308716A21612B" modified="2022-05-25" version="1" fragment="single">SFLLFAGKTVYRYRRYPERHQVIGQVFSHTAPILDLDLSPYNEYLITAGKDNMVGLLHLGAPNHGWTQRYEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTX8</accession>
    <name>A0A8J5MTX8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="5">eIF3e</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Eif3eb-L</name>
        <name evidence="8" type="ORF">Hamer_G019619</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with mxt.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025477">
        <property type="protein sequence ID" value="KAG7164255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTX8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="241"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7164255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="458" mass="53260" checksum="7E869A02DBF253FC" modified="2022-05-25" version="1">MAEYDLTWKLGPFLDRHLVFPLMEFLSVKGVSEFCMELVPIADVTLIFQIYDETDLQRAKLELLSSTNMVDFAMDIHTSLYPDQPATTELPDRRSRVVSELKRLQTETEPIFKIFSDNEVQKQLQASRDHRTLMQFLVDNYDFRPEMLDTLYSFAKFQYECGNYSGAADYLYLHRGLVPGSDKNFLNGLWGKLASEILTQHWENALEDLNRLKEFIEANLTTSPLQALQQRTWLIHWSLFVFFNHPKGRELIIEMFLYQQPYLNALQTMCPHVLRYLATAVVINKNSRRAAMKDLVRVIQQESYTYKDPITEFLAHLYVDFDFDAAQEKLQQCAAVLENDFFLVACQNDFIENARLMIFELFCRIHQCISINMLAEKLNMTPKDAERWIVNLIRQAKLDAKIDSQQGHVVMGTQAVSPYQQLIEKTKTLSFRTQMLSINVEKKATARYSEGPSWAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MV75</accession>
    <name>A0A8J5MV75_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Semaphorin-1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SEMA-1A-L</name>
        <name evidence="9" type="ORF">Hamer_G017249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MV75"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000346">
        <property type="entry name" value="Sema-1a, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF127">
        <property type="entry name" value="SEMAPHORIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="8">
        <location>
            <begin position="1"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7164856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="727" mass="79955" checksum="70873F490902B286" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVN2</accession>
    <name>A0A8J5MVN2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024174">
        <property type="protein sequence ID" value="KAG7165533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVN2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="65" mass="7347" checksum="B61CC0EA37D02F2E" modified="2022-05-25" version="1" fragment="single">TQIQNIIDLHQKELFRVSVKKKAAQDKNYVGGTEEERAQTPGPSGARFTAIHSSEESMFRTVQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWL0</accession>
    <name>A0A8J5MWL0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Electron transfer flavoprotein subunit alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Etfa-L</name>
        <name evidence="5" type="ORF">Hamer_G017084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWL0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7167180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="188" mass="19968" checksum="1A91E687E07F06CA" modified="2022-05-25" version="1">MKAAGRRLQSTLVVAEHDNKTVTPITLNAISASKKLGGDVTCLVVAELSKTSGVSKILVADSEALVGFMPEYLTPLILATQDQFKFTHIVAGASAQGKSLLPRVAAKLDVSPISDIIEIKAPDTFVRSIYAGNALLTLKSKDPIKVITVRGTSFEAVSLDGGNAASDEVAMPDVPADRYQRRSGDEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYI7</accession>
    <name>A0A8J5MYI7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative immunoglobulin-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G010243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYI7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF15">
        <property type="entry name" value="BEATEN PATH IIIA, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="166" mass="18031" checksum="0A5E93A1B8B9576D" modified="2022-05-25" version="1">MAQRDKSWGGKVRVVNVSLAAEGPFHYLPDGRPVITGIKSQYLVMDWVDLTCTSRRSRPPPTLTFTINKQPVNQHDHDGLSTSSLRLRFSLLPRLLQEGDAVVLCISKIPGIYEQMVQEVLTTNPPYHASVLGGGAAPGQATTVASTATLVISLLLTLCVFLSPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZF5</accession>
    <name>A0A8J5MZF5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Xenotropic and polytropic retrovirus receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">XPR1-L</name>
        <name evidence="10" type="ORF">Hamer_G011740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7169041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZF5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14477">
        <property type="entry name" value="SPX_XPR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="8">
        <location>
            <begin position="391"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="607"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7169041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="669" mass="77718" checksum="897BB94734C0885A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZI2</accession>
    <name>A0A8J5MZI2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methanethiol oxidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G022735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the selenium-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018399">
        <property type="protein sequence ID" value="KAG7169116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZI2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008430">
        <property type="term" value="F:selenium binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008826">
        <property type="entry name" value="Se-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300:SF0">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05694">
        <property type="entry name" value="SBP56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0711">Selenium</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7169116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="458" mass="51386" checksum="B9CC1C86DCFCAF40" modified="2022-05-25" version="1" fragment="single">MAGPGYASPLEAMKGPREKLVWVPCIKTKTGKPDYLATIDIDPQSPNYCKVIHRLYLPYLDDEIHHTGWNTCSSCYDDPSRVRNRLVLPAIGSSRVYVVDISEETQPKLFKVMISTLGDAQGKAKGSFITFDSFTFEHTGPWTDMDSEYGYDYWYQPTHDVLVSSEWGCPTAFFKGFDPKDVEAGNYGSHINVYSWSSHRLLQSIDLGLEGIMPLEIRFLHNPLATQGFVGCALYANVFRGTGLMGPKVISIPIKKVEGWALPEMPGIMTDILISLDDRFLYFSNWAHGDIRQYDITDPEHPKLVGQIFLGGSIVKGGPVKEQPDPVHIQGRLIEGSPQMLQLSLDGKRLYVTDSLFSPWDKQFYPKLAKNGSLMLQIDVDVENGGLALNQNFLGMPEVTGECLRSTREARGHQGKPEVTRGWTECTRKCLKSPWEARDRQGFPEVTRKCPRSPGDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1V5</accession>
    <name>A0A8J5N1V5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G014774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1V5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="173" mass="19947" checksum="9A8ADC51D54FEEC5" modified="2022-05-25" version="1">MVWVCRLELWYAVYRGWSYYSMQPARLGYYSMQSLQSWATMVMQPAGWSCYGMESGLELLSMLRPAEAGAALVCSLQSWSCYGVQSAELELLWYAAYRAGATIVCSLSWSYYSMQRPTGWSYYSMQPLQSWSCYSVHGLQSWSYYSMESAGWSCIVCGLQAELWYAVYRLELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N310</accession>
    <name>A0A8J5N310_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Rpl3-L</name>
        <name evidence="7" type="ORF">Hamer_G001155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The L3 protein is a component of the large subunit of cytoplasmic ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N310"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7172149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="402" mass="45725" checksum="B6BDDAC201A90C92" modified="2022-05-25" version="1">MSHRKFSAPRHGSMGFYPKKRSKRHRPKVKAFPKDDKNKPVHLTAFLGYKAGMTHIVRVADKPGSKINRKEVVEGVTILETPPMICVGVIGYIETPRGMRALKTVWAEHLSEECKRRFYKNWHKSKKKAFTNASQKWQDQVGKKVIEKDLAKIKKYCSSVRIIAHTQIKILKKRQKKAHIMEIQLNGGTVPEKVDWAVSHFEKQVPVSNVFAQDEMVDVIGVTKGKGVKGVTSRWHTKKLPRKTHKGLRKVACIGAWHPSRVQFTVARAGQKGYHHRTEMNKKIYRIGQGVHTKDGKVVKNNASTEYDFTEKTITPMGGFPHYGEVNQDFVMIKGCCAGPKKRVICLRKSLVVQTKRIALEKISLHFIDTSSKMGHGRFQTSAEKAAFMGVLKKDKKKKLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3G4</accession>
    <name>A0A8J5N3G4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011474">
        <property type="protein sequence ID" value="KAG7172374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3G4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="215" mass="24074" checksum="98AB8948AB64331B" modified="2022-05-25" version="1">MLTNSFICKENALKQVCPIGDTIKLNKLTAFTSMIKSQLELATSLHKDDWTLLQALHSLSNKKALSSNGKLTSLRDDLLHLRQLAEQDTNIHMSPHPYSIGLRYGNVQSGAGHSKTRHCLWSSPPGNRQLCRLMAARGTLRFLSTGYAVGCNQKNRYSGYGRLPTWHPCNHEEADTGMMVHALMPWNVVWRILIRTVIRCCHPYVGLPIDGGVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3U7</accession>
    <name>A0A8J5N3U7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3U7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="83" mass="9185" checksum="CC454E147D66F148" modified="2022-05-25" version="1">MQALARDHHMPPSVKDHKLKGVDPNPRLSLVEERNRRRPLPDPLLHPDVVCQGYVLAIVKTGALGLHLYTITSKKSGNQTGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5M2</accession>
    <name>A0A8J5N5M2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G025664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009683">
        <property type="protein sequence ID" value="KAG7173494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5M2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="95" mass="10360" checksum="3770458F3C500E9B" modified="2022-05-25" version="1">MASRSMDDDIRNECCLRLASLGGRQHCPKDQLYLGKLLVTDPGIEVGDGRRIELTSLLTLARVDGVTARSWLVLGESGEIWSALSSLQAETTEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5N4</accession>
    <name>A0A8J5N5N4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sodium-independent sulfate anion transporter-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Hamer_G020018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008712">
        <property type="protein sequence ID" value="KAG7173870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5N4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="5">
        <location>
            <begin position="60"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7173870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="146" mass="16001" checksum="81D2DD150CED371B" modified="2022-05-25" version="1">MTGRQQQWVRTHANATCLKIVLEATNLIKRGARRTFSKETLLKRIPITKWLPNYKLEYLGGDVMAGFTVGLTVIPQGIAYAAVAGLPANLNLYGLYRLMGCFVYMIFGSCKDITIGPTAIMAIMTHEYSGSAVLKMLCCCVSSVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7B3</accession>
    <name>A0A8J5N7B3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Ano8-L1</name>
        <name evidence="9" type="ORF">Hamer_G015275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7175056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7B3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF74">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="8">
        <location>
            <begin position="64"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7175056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="250" mass="28913" checksum="9DEBEE886652FC60" modified="2022-05-25" version="1" fragment="single">CSHSLSCTHSLSCTHSLDYFTQFAEQVMTVLRNHSLTEKFFVEVVRPVHTAPLEEEPVPVLALDPKDPRITQAKEEASLDPYEDAYDDYLEMFMQFGYVFLFSSVYPMAAFWAVLNNVLELKTDAFKLCRVYQRPRVKKVGSIGVWQASPVEWVLLFVLLEHLILVAKMGLMWLVPNQPLWVRQALEKITYQSKLALKNERGKKTRRHLSRRFRSVHGMPRSGSRSRGTTPVAQNGGVRHRSPPRDYRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8V2</accession>
    <name>A0A8J5N8V2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Bifunctional coenzyme A synthase</fullName>
            <ecNumber evidence="20">2.7.1.24</ecNumber>
            <ecNumber evidence="4">2.7.7.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">COASY-L</name>
        <name evidence="24" type="ORF">Hamer_G020692</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19802"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:18246"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="17">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="18">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">In the central section; belongs to the eukaryotic CoaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="20"/>
    <dbReference type="EC" id="2.7.7.3" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010004953">
        <property type="protein sequence ID" value="KAG7175645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8V2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02164">
        <property type="entry name" value="PPAT_CoAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000899">
        <property type="entry name" value="Bifunctional coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000089">
        <property type="entry name" value="Bifunctional coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="23">
        <location>
            <begin position="192"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00061673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00066359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00067394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAG7175645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="565" mass="63359" checksum="AB14416E7038D23B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N950</accession>
    <name>A0A8J5N950_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Trypsin domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G009033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N950"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="234"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7176255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="541" mass="59750" checksum="AB7A215FDE8C09A0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N981</accession>
    <name>A0A8J5N981_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Basement membrane-specific heparan sulfate proteoglycan core protein-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Hspg2-L1</name>
        <name evidence="3" type="ORF">Hamer_G001195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N981"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="59"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="140"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="302" mass="33576" checksum="7BA5F669B8F25CB5" modified="2022-05-25" version="1">MVRGPPFAIFWCAAILAGYEFPWVMTLGSPASDTFPASGYDISAALADLNKPKAVPEGPRLVSRTYSRLIVSRGSSVTLNCTVEDASDVSVTWTRDKEVLTVDKFSLRFSQVMPEDSGIFQCHVGTDPEQVARVKLVVIDAYSVIFGSSEVSVAVGGTLYLLCLVLQVTDIPEYILWYHNQKVIDYSRSSISVKTDEETRSSELRVWDINYTDAGNYTCEPSNAAPAFVSITVFKDTNKKSGRTEKCDECVLYIQLGATFAFFTLSFLIAFCIHSRDNTSRPWLEHSLSEDLYVPPDYDKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA96</accession>
    <name>A0A8J5NA96_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">Hamer_G016898</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Photoreceptor required for image-forming vision at low light intensity. Can use both retinal and 3-dehydroretinal as visual pigment. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Signaling via GNAQ probably mediates the activation of phospholipase C.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Interacts with GNAQ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Cell projection</location>
            <location evidence="18">Rhabdomere membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7175957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA96"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15079">
        <property type="entry name" value="7tmA_photoreceptors_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000044">
        <property type="entry name" value="Opsin, ultraviolet-sensitive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001391">
        <property type="entry name" value="Opsin_lateye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00238">
        <property type="entry name" value="OPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00578">
        <property type="entry name" value="OPSINLTRLEYE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10 20" id="KW-0157">Chromophore</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11 20" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4 20" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="6 20" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="15 20" id="KW-0807">Transducer</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="22">
        <location>
            <begin position="72"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG7175957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="380" mass="42662" checksum="F8C854EACC28460A" modified="2022-05-25" version="1">MSQYHLSCVNATYHEQGISFGYPEGLTIVDFVPDTIKHMVHEHWYSFPPVNPMWHYLLGAIYIILGFFSITGNGIVIYLFIKATGLRTPANLLVVNLALSDLIMLTTNFPPFAYNCFSGGQWMFNAFFCELYAALGAITGVCSIWTLGMISWDRYNIICNGFNGPKMTMTKAVVMCLFCWAMAIGWALPPFFGWGKYIPEGILDSCSYDYLTQDWNTKSYNIAIFIFDFFLPASIIICSYVFIVKAICAHEAGMRAQAKKMNVSNLRSNEADNQRAEIRIAKTAIANVSLWLTCWTPYAAITIQGVLGHHENITPLVTMLPALLAKSASCYNPFVYAISHPKFRQALTVHLPWFCVHETQPKNDDSKSVTSNTTANDEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAR8</accession>
    <name>A0A8J5NAR8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7176049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAR8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="179" mass="19665" checksum="7BFF66030AD68377" modified="2022-05-25" version="1">MEAAVNNLEEAPKLMPGNVRYGGQNPPHPTPTRAMSLDSLHDKNANLDSKAHEYIPSRITRTTPKINEAAMQFVKTGPAVLYKSATEQIKKAEAVKAMRQHLIAEEADWQEVGISMWSSLFTNQGLLQGVPLGLPHGFFPLVVSVGAFMTCLMVESSQGILWNIFSKHNNSFSSVSKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ND39</accession>
    <name>A0A8J5ND39_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate sulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000685">
        <property type="protein sequence ID" value="KAG7178220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ND39"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="46183" checksum="6EA18D2033318D29" modified="2022-05-25" version="1">MEILHESSVYKDSRQPTRPKDSGCEASSWSSGFSLQYLTTLKKVSQAYGFLTGKRFGTFSRHRLNETKKASSNPERKFITLAKKMLTVGKHVGVVAAVNIGYSATEQSKLKKYFSNASFTMAEFLEHVLWTRDVDLLDHHWTPISQLCGPCTADYKYIVRHENPKEAEYLLGLLHLQENTIPRKHKSIGALHDNGSATAPPPPLLLRHLTTPPPLLRHLPTTTTAPPLLRYHCTATTTAAPPPLTHHRCPTAATAPPPPHHSHFYSTAPPPPMLRQCPATTTAPPPPPPLLRHHRATTTAPRQPRQPLTPHHSHCSATTPSPPHHHHRCPTTATDLPPPLTHHSQCFTTTTAPPPPLQLPHHHHYPLPHHHHHTTATPLTRHRATTTATDPPTATDPPPPLTDPPQPLPTPPPLLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ND65</accession>
    <name>A0A8J5ND65_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inner centromere protein A-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G028551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002012">
        <property type="protein sequence ID" value="KAG7177503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ND65"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990385">
        <property type="term" value="C:meiotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051257">
        <property type="term" value="P:meiotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051310">
        <property type="term" value="P:metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="586"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="819"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="590"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="681"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="819"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7177503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="914" mass="103947" checksum="D8E0F81AEAA6C511" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDE5</accession>
    <name>A0A8J5NDE5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Dctn1-L</name>
        <name evidence="15" type="ORF">Hamer_G008401</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="14">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="79"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="207"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1232"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="382"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1127"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1234"/>
            <end position="1256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7177732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1473" mass="163335" checksum="FCB39288EF0F9FAF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NE85</accession>
    <name>A0A8J5NE85_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NE85"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7178012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="82" mass="9363" checksum="0F39FF6CD75D094E" modified="2022-05-25" version="1">MDYGSRNKMEGKPPHLFFFAMVKGELVVNSGALDVFYQVKGGDDYTVNWVVTIAVSWMSFYQVNGVVNSEVLDVFYQFYNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NEC6</accession>
    <name>A0A8J5NEC6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress protein DDR48-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">DDR48-L3</name>
        <name evidence="2" type="ORF">Hamer_G028741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000176">
        <property type="protein sequence ID" value="KAG7178287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NEC6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="867" mass="104991" checksum="1AFC9130E93764EA" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NEJ5</accession>
    <name>A0A8J5NEJ5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Epididymal sperm-binding protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ELSPBP1-L</name>
        <name evidence="9" type="ORF">Hamer_G008202</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the seminal plasma protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NEJ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051666">
        <property type="entry name" value="SP_Capacitation_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22918:SF6">
        <property type="entry name" value="EG:8D8.1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22918">
        <property type="entry name" value="SEMINAL PLASMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Fibronectin type-II" evidence="8">
        <location>
            <begin position="92"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="8">
        <location>
            <begin position="168"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="8">
        <location>
            <begin position="352"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7177566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="417" mass="45616" checksum="64D5F2FB71F66F05" modified="2022-05-25" version="1" fragment="single">ITTSPSSELLTSSLPPDYFNESPSLLKSPAQPIQFNEIPLMSPLLTTTPHTPTSPPPTSIVSSPSLPPTPTPPSGPQVPSAEWVTGGGNVTVSGKPCIFPFVYKGQEYEQCIQEDAKGPWCPTLLNKHKQPIASEFCKGNDASVKPPLTGNDTSVKPLHVSSQRQFTKDGVECIFPFTYKGIQYWNCSSTERPALWCATLVNAKLQPLQSGYCANNIASIPFQPPPTVIGMAMTIQRGPCIFPFLYRGIVYEQCACVDAPACWCPTSLTRNNEPAVSDYCRDDSECFPKSPTTFMQVRFVCISDTHNRTDCLHYSIPDGDVLLHGGDFTIRGDPHNAHVFNQWLGLGAPVTVDGWACHFPFRYKGRTYTKCTSEDSNHPWCATIVNDSDQPTESGYCKGSNQPPPSKPPVRVPQPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TC69</accession>
    <name>A0A8J5TC69_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pseudohemocyanin-2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Phc2-L2</name>
        <name evidence="4" type="ORF">Hamer_G014669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tyrosinase family. Hemocyanin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TC69"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF5">
        <property type="entry name" value="FAT-BODY PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035316610" evidence="2">
        <location>
            <begin position="16"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7171543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="684" mass="79510" checksum="E9EB41190254CBCD" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TCR4</accession>
    <name>A0A8J5TCR4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin-Q</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cyclin-related protein FAM58A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CCNQ-L</name>
        <name evidence="7" type="ORF">Hamer_G014772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin-like FAM58 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TCR4"/>
    <dbReference type="OrthoDB" id="6349934at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20534">
        <property type="entry name" value="CYCLIN_CCNM_CCNQ_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20535">
        <property type="entry name" value="CYCLIN_CCNM_CCNQ_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048055">
        <property type="entry name" value="Cyclin-Q_first_cyclin_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048053">
        <property type="entry name" value="Cyclin-Q_second_cyclin_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="46"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7171633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="267" mass="30468" checksum="F6D83CF98501DDBD" modified="2022-05-25" version="1">MNSSAKSHEDGKDKRASLLQINLMPKEFQNPPVDYTKNYNHFSGARFIIECGIKLKASVLTTATAATYYHKFFTVATLEEYDPYLIGSTCIYLASKVEDDDIKIRDIINVGISNVRRGDAPLSLDPYFSLRDSLIQAELLLMRVLGFKMRVELPHKFILHYLLSLKEWLGEETFKNIPIVHMAWTITQDIYHSPIVLKHSPQLLAVTVLNIVIQVYGIVVPGDDELSDRSWFTVLQPDCTTQAVWNLTSKILLMYQEEEDLVLSIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TG49</accession>
    <name>A0A8J5TG49_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 21">Cytochrome c oxidase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">Cox2-L2</name>
        <name evidence="25" type="ORF">Hamer_G009528</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="21">Binds a copper A center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Mitochondrion inner membrane</location>
            <topology evidence="21">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TG49"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00310">
        <property type="entry name" value="ATP-synt_Fo_a_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="entry name" value="ATP synthase, F0 complex, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="entry name" value="Cytochrome c oxidase, subunit III, four-helix bundle"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="entry name" value="NADH:ubiquinone/plastoquinone oxidoreductase, chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011759">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403:SF7">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02790">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="Cytochrome c oxidase subunit II-like, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="Cytochrome c oxidase subunit III-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="F1F0 ATP synthase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50999">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8" id="KW-0138">CF(0)</keyword>
    <keyword evidence="21" id="KW-0186">Copper</keyword>
    <keyword evidence="14 21" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 21 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 21" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="10 21 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 21" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit II transmembrane region profile" evidence="24">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="23">
        <location>
            <begin position="253"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="25">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAG7172187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="412" mass="46261" checksum="B4F94C3599D661C6" modified="2022-05-25" version="1" fragment="single">MSASPLIEQLIFYHDHTMVVLILITTFVGYMIAAIFPNAFVNRFLLENQTIEMKLITLESLLKQLGTNDIEDFLQVEFDSYMTPSNELDLSGFRLLDVDNRTVLPINTQVRMLVTAADNLFIINQLIINFCWVTFYSLPLLSGSFTLSTIPQGTPGLLIPFIVLVETLRNIIRPGTLAVRLTANIIAGHLLLTLLGNMGPSLSLTLVSFLMLAHILLLILESAVAIIQSLAPAKIFSYYFNNNSMMTRCNTSVVLFFFFGAFFHGRLSSTIEIGICWPPVGIQPFNPFQIPLLNTTILLSSSSFRICRSFFYNCNSVYGSTFFVATGFHGLHVIIGTSFLTVCFYRLYKCHFSSDHHYVSTTFVIRSVVIILASILSKKLVTDREKNSPFECGFDPKGSARLPFPLRFFLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIE2</accession>
    <name>A0A8J5TIE2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DAZ-associated protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Deleted in azoospermia-associated protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proline-rich transcript in brain protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Dazap2-L</name>
        <name evidence="11" type="ORF">Hamer_G006850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1. In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters. This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death. Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes. Plays a role in stress granule formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIE2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022730">
        <property type="entry name" value="DAZ_assoc-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31638">
        <property type="entry name" value="DAZ-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31638:SF3">
        <property type="entry name" value="DAZ-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11029">
        <property type="entry name" value="DAZAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7172637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="125" mass="13053" checksum="0488EA0AD903CF81" modified="2022-05-25" version="1">MAAAQQAQKLAYSQQAYQQQQTALYMQQQQQLYLQQLQGYYQPHPPPGSAAAAAGFQPGQNVLVMNGYDSGARFDGIAQPSIPPPPPGIAPNAAQLAGASGAQVSMTQKKGSFLTGGSGGGYTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TL55</accession>
    <name>A0A8J5TL55_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Immt-L</name>
        <name evidence="9" type="ORF">Hamer_G016429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TL55"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7174528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="707" mass="78211" checksum="69F49C148E69B923" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLG8</accession>
    <name>A0A8J5TLG8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G008355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLG8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="141" mass="15776" checksum="A44491473F08FBE3" modified="2022-05-25" version="1">MINSAVGDLHNCWCGMFIELDEEVHMVYSLDSATVNSCDDVSTCKTTCASEFNTYTAGGDLNHVLGDGYSVGQEICLRMVERHGIHNIYHATVYGYGNVCNGPWVYDGVSSINSLCCHKGFYRPCEYYSLKKEKMDEKKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TMS0</accession>
    <name>A0A8J5TMS0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Glutamate receptor-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Glrk-L1</name>
        <name evidence="18" type="ORF">Hamer_G001457</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TMS0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000078">
        <property type="entry name" value="glutamate receptor ionotropic, NMDA 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="16">
        <location>
            <begin position="94"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="17">
        <location>
            <begin position="106"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7175382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="488" mass="55295" checksum="870E58C842086254" modified="2022-05-25" version="1">MKVLEVSSPTVNTFDLHEVWSSGPERDLRQDLLATWSANVLLGTAELENNERQDGQLTDGGGSSHEPEKWITTGRLTISNTPKYERRRDLTGIHFVITSINDSRAHNSHYSKDLGRDVLNGFFGDVWELLKLEMNFTYLVMTPADGEFGSLNNNGSWTGMIGDVLSGRAHVVVAFLSQTYSRAQVIDYSSVLIKFSYRIFARPPKLSTLSWTSYTRPFSTGLWIGLLLLLMIMAMVCWGVSHCYHQMLLPTSVGDQLPKEIMGYQKWKKDAPLLVWAAFTQQGWPTAPEVGPLRAVFWTMYVVGVVVVAAYSATLVAFMTVVDDELQFDSLEDLKMLPKYRLGIQKGSMLEEYFKNKNFLEYWETLIKPYSDTPLKSFNDIRAIAQKDPQYAYVGTYEIQRLDPVGACIFKSARQHLLFNDGALGWPRGSSYVQLFDHFINKFRESGLLQKLMTKWYPRPYTCPDQPVVALGFQQDGTPISKGDQSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TQ21</accession>
    <name>A0A8J5TQ21_HOMAM</name>
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        <submittedName>
            <fullName evidence="6">C-myc promoter-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DENND4A-L</name>
        <name evidence="6" type="ORF">Hamer_G015351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
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        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
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        <property type="entry name" value="DENN_Domain_GEFs"/>
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        <property type="entry name" value="MABP"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
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    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF30">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN CRAG"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <end position="195"/>
        </location>
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            <end position="837"/>
        </location>
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        </location>
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            <begin position="937"/>
            <end position="947"/>
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            <begin position="1493"/>
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            <begin position="1954"/>
            <end position="1975"/>
        </location>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JBI4</accession>
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        </submittedName>
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        <name evidence="1" type="ORF">Hamer_G030165</name>
    </gene>
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        <name type="common">American lobster</name>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Kohn A.B."/>
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                <person name="Timp W."/>
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                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
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                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
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            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039841">
        <property type="protein sequence ID" value="KAG7156150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JE93"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="194" mass="22581" checksum="83C9F55266A79584" modified="2022-05-25" version="1" fragment="single">VELYQHRSYGKVYSSKSVARYPSSVGHDLVAVTDKENYVLTEEEKEIIIHLKEWWAKHCSEFTPQGEDNLYAKLNAADIEERIHIMMILKLQPLSTDQEIIQKENCSEESVTTKLKKRYLGLLQKRASIEPVIKFVEQNHSFSLQTPSTNMAEVNLVTKKYKVVNKVIYEKSSVKQQQMQKLQVFHPKQQVKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFB8</accession>
    <name>A0A8J5JFB8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative E3 SUMO-protein ligase RanBP2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RanBP2-L2</name>
        <name evidence="2" type="ORF">Hamer_G006579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFB8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="170" mass="18941" checksum="B91DDE45BD73324F" modified="2022-05-25" version="1">MKLRLHDDLSCSSNSVKPTGVDEEDGADDDDDEDDDEDDEEDDGVDDKNEEKEDVEHEDEDTVIFKKNCTMYIQENESWQELAVGDLCITCPNNNGDGGARIIMTTDSGDFVVEDTLTRHSTMKKECYAATWTSPKSELVVATSYQVVFSSSSDLDEFETAFSKASAYCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFI4</accession>
    <name>A0A8J5JFI4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative SCAN domain-containing protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFI4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCAN box" evidence="1">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="88" mass="10577" checksum="8CF33E7C26B2AC36" modified="2022-05-25" version="1">MSESVDYETVKEAVLKTVEMDPEVYRRRFRDIRKMSGQTHLEVARECGMRFDRWCKSEEVKTVDDIRQLVLLEHFKSLVHPEIKYEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFJ8</accession>
    <name>A0A8J5JFJ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gypsy retrotransposon integrase-like protein 1-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GIN1-L7</name>
        <name evidence="1" type="ORF">Hamer_G024164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040771">
        <property type="protein sequence ID" value="KAG7155729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFJ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029309">
        <property type="entry name" value="CaRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47456">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47456:SF1">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15299">
        <property type="entry name" value="ALS2CR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="232" mass="26471" checksum="EDE2FAC91F8203CC" modified="2022-05-25" version="1" fragment="single">YSVSVGTKGRGFDPVPVEYTGVPFIEAGTYVLECHLGNDSGAWNKRRYAANRDQMEEKKLMVTKRRILTQSTKKVGCPAKVHIKRILRMPDFKVKNNTTAERSRNRVRIIQALREDIESVNFQTVYYILLPQLESHKFHSVDIVAGVMVSKGEAGLLHLQQVRHYLETGTYLPSVPSKKKNGIRKSSKEFIIDGKTMYYIGKDGSQKRIVPLSENERQRAFQKCHALTSGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFM3</accession>
    <name>A0A8J5JFM3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-binding protein NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NOB1-L</name>
        <name evidence="12" type="ORF">Hamer_G015052</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May play a role in mRNA degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NOB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFM3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="11">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="10">
        <location>
            <begin position="404"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="299"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7154690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="541" mass="60935" checksum="E9E61FF369B6EA2C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJG4</accession>
    <name>A0A8J5JJG4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Caspase Dronc-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dronc-L2</name>
        <name evidence="4" type="ORF">Hamer_G021839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035368">
        <property type="protein sequence ID" value="KAG7158386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJG4"/>
    <dbReference type="OrthoDB" id="6097640at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097169">
        <property type="term" value="C:AIM2 inflammasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072557">
        <property type="term" value="C:IPAF inflammasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072559">
        <property type="term" value="C:NLRP3 inflammasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF3">
        <property type="entry name" value="CASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="3">
        <location>
            <begin position="353"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="2">
        <location>
            <begin position="495"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7158386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="575" mass="65121" checksum="2D12768F5F10B75F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJK4</accession>
    <name>A0A8J5JJK4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032840">
        <property type="protein sequence ID" value="KAG7159692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJK4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="101" mass="10621" checksum="626395959B84F876" modified="2022-05-25" version="1">MEGGVVVGSAVTRLDYYMYGAVQWTVLRRRSSSSSGGSRIGVVSGSDGGRASGYSATEMGAKGGASGVGYVPRGKSKEGDDQVLCIYLGGYEEARRRRSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJU7</accession>
    <name>A0A8J5JJU7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Slc16A3-L</name>
        <name evidence="5" type="ORF">Hamer_G016064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041065">
        <property type="protein sequence ID" value="KAG7155683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJU7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="95"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7155683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="526" mass="57451" checksum="5A782A06A3C40F6D" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKK5</accession>
    <name>A0A8J5JKK5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 94-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Tmem94-L9</name>
        <name evidence="3" type="ORF">Hamer_G029191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036631">
        <property type="protein sequence ID" value="KAG7157863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKK5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="2">
        <location>
            <begin position="156"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7157863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="200" mass="22794" checksum="CBC915243E273B11" modified="2022-05-25" version="1" fragment="single">MACSADGLPTSEALSLLHEDISIALDEYQKTEAEKNKGFGPKSVLYEAFHHKSSLSVFHWTSVIALIVEGIVLLVAFAACNDPRYQHLPAESFFIFLAVILNVYLVWWDTQLRHKEVPRLTHNVLKDLKEYHGNVLWSAENYPHLHSPCITLQWTRRDGNTVNLPWSLLVRGDIILMKPGQKVPARCRPMQVSSIIFIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKV7</accession>
    <name>A0A8J5JKV7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G030735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036114">
        <property type="protein sequence ID" value="KAG7157901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKV7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF9">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="240" mass="26516" checksum="B8FEF05209B42F3E" modified="2022-05-25" version="1">MQLVVKESKQLVVTDKKQVLTVPPRKDTANLAPCNHEVADTRMMVHAADALESGHRRILIRTVDTDVVILRVALANEQSEVLDELWLTFGTGKNRRYIAAHQIAKALGPEKSIALPVFHAITGCDTVSAFAGHSKKAAWATWNAFPEVTTAFLSLASTPSELPDGVLSTMERFIVLFYDRTSTCCDVNVLRKKLFSRKSRSLEHLPPTRAVLEQHKERCLSGWTYLGTGGNSVCQSAITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JL30</accession>
    <name>A0A8J5JL30_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Epsin-1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Epn1-L2</name>
        <name evidence="2" type="ORF">Hamer_G024851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043144">
        <property type="protein sequence ID" value="KAG7155109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JL30"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="245" mass="27366" checksum="7D9FAB05D51DEBA8" modified="2022-05-25" version="1" fragment="single">VARESDLSTQTRFLISLQHVVVCVPRSWRRELFNWMYGAHIHVVVCGSLQQMYMMCGSLHQLYIVCGSLHQLYIVCGSLHQLYIVCGSLHQLYIVCGSLHQLYIVCGSLHQLYIVCGSLHQLYICVAPCTSCPHSVWLLHKLYTKCVAPAQAVYILCIMCGSLHQLYIMCGSLHQLYIMCGSLHQLYIMCGSLHQLYIICGSLYNCTVALVSLQFFLDSLSPPPPPHTPRLTCLCVVGVRKGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JML6</accession>
    <name>A0A8J5JML6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor Sox-8-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Sox8-L2</name>
        <name evidence="9" type="ORF">Hamer_G024481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029889">
        <property type="protein sequence ID" value="KAG7161117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JML6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050917">
        <property type="entry name" value="SOX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803:SF5">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7161117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="246" mass="29137" checksum="3BCE882AAA0C7700" modified="2022-05-25" version="1">MIRDGTGDSERRKVHVKRPMNAFMVWAQEARRKLSCSHRQVHNAELSKSLGRIWRQTTGHLAKMHSQPGCVVASRGRLHHQHQDQFTRLTVLYCHKRYYNIHSRKIQSHQHNTGINSLSPPRHHPHVTRPQKKRMDGCRHLWQVQLIKRRRKEEEEERGGGGEGEEKEGRNRREEEGGGDRREKRGREKRGEGRRKWQGWKRQKIEEEEERIRIISTPMRVILHILRKQTHPTPPSSVFLNPPPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPC9</accession>
    <name>A0A8J5JPC9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-galactose transporter senju-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">senju-L</name>
        <name evidence="7" type="ORF">Hamer_G010832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPC9"/>
    <dbReference type="OrthoDB" id="419167at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7162167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="368" mass="41020" checksum="F4179482165775FC" modified="2022-05-25" version="1">MSANRYEHGKRFDKLFPTTCSFIVFLAYMALFINQGIVVTASQRADNSYSYNTVTVVLLTEATKLVASLLIYLKDNKLSTLFTDIRTNIRVLGLYMVPALLYCLYNNLAFVNLAVFDPTTYFLLLQLRVVVTGVIFQVIFKKQLSKRQWVSLIILTIGCIVKQLSTSKKTDLSPTESDVPFSVMLSNLVSLHTGLLLVQVFCSCLAGVYNEKLLKDTGAEVHIMVQNVFMNINSIICNAVVLLYRGELISAFSTTSLSQVWQPVVVVIILNNAAVGIVTCFFLRNLNSILKTFASALELMFTAVLSWVIFGIAVNWWTAVAIALVIFATYMYAQNPVVNRGRLDELEKDTSSEPEGLTLIKNVPPTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ61</accession>
    <name>A0A8J5JQ61_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative NFX1-type zinc finger-containing protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ZNFX1-L2</name>
        <name evidence="3" type="ORF">Hamer_G011464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQ61"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035329424" evidence="2">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="113" mass="13202" checksum="5D7E6CDC0148C565" modified="2022-05-25" version="1" fragment="single">GNNYLKRVWWWILMMCGAKRGYKNDHHIDENYDNKEFFGDFYEYSYHDSNGDDHSSFHADEGHHHAKDDHAKDDHSKGHHAKDDHYKGHHSKDDHYKSQHGHTAGGYGHGDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQD0</accession>
    <name>A0A8J5JQD0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose transporter type 1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Glut1-L1</name>
        <name evidence="7" type="ORF">Hamer_G016567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQD0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF128">
        <property type="entry name" value="GLUCOSE TRANSPORTER TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="9"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7159179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="127" mass="13607" checksum="E305C2869B2C67BA" modified="2022-05-25" version="1" fragment="single">GLTCFLCYAIFAAVLGMFQFGYNTGVINAPQSVIENFIGDCWKERFNKNIEGSKQDLLWSIAVSIFAIGGMIGGICGGSVGNKFGRKKGLLLNNLLGVGGACLMGFSQMSYSYEMLILGRLVIGINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQJ9</accession>
    <name>A0A8J5JQJ9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G025042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027733">
        <property type="protein sequence ID" value="KAG7162286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQJ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7162286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="201" mass="21606" checksum="4D4A11E10B808C06" modified="2022-05-25" version="1">MVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVWMVVVVVVVVVVVVVVWWLVVVVVVVVVVVVVVVEVVVVGEAVVVVVVVVVVMVVVVVVVLKVVVVMVMIVKSGDDTQVSERTQVSERTQVSERTQVSERRYTCKRETYTGLTDKRVTSRRGPGITAGLHNIASQECQARLTPAFITYPRPPPPPPTPPDALPVSDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQK1</accession>
    <name>A0A8J5JQK1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Srp54-L</name>
        <name evidence="18" type="ORF">Hamer_G008078</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="16">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQK1"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000002">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11 16" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="17">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG7162522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="502" mass="55966" checksum="0E4B37F0FEB5089F" modified="2022-05-25" version="1">MVLADLGRKITSALKSLNNATIINEDVLNDLLKEICAALLESDVNIRLVKQLRENVRSAIDFDEMAGGLNKRRMIQTTVFKELVKLVDPGTKPYVPVKGRPNIIMFVGLQGSGKTTTCTKLAYYYMRKGWKTCLVCADTFRAGAFDQVKQNCTKARIPFYGSYTEVDPVVIAMDGVDQFRKEGFEIIIIDTSGRHKQEDSLFEEMLQISNVCKPENIIFVMDASIGQACESQARAFKEKVDVGSVIITKLDGHAKGGGALSAVAATQSPIIFIGTGEHIDNFEEFKTKPFISKLLGMGDIEGLIEKVNDLKLEDNEALIKKLQHGHFTLRDMYEQFQNVRKMGPMSQIMGMLPGFSTDFLTKGGEQESMARLKRLMTIMDSMTDEELDSLDGNKLFQKQLNRISRVARGAGVMEIEVKDLLNQYAKFAQMVKKMGGMKGLFKGGDMSKNVNQMQMNQLNQQMAKMMDPRVLQQMGGFKGLESMMKQLQQGGGPMGMGKNPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQX9</accession>
    <name>A0A8J5JQX9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative CENP-B N-terminal DNA-binding domain-containing protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G025688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027338">
        <property type="protein sequence ID" value="KAG7162707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQX9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7162707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="214" mass="23765" checksum="7FD8635DFAC9321E" modified="2022-05-25" version="1">MPPKRPAAPSGSTPKRARRVLTLNEKNEVLKQLDSGMSYAAVGRHFGLNESSVRFPTAEPQLRNIITMANEVGGEGFSDLTAEEVQEELLGNVGDPFTSDELEQLVELQDETDDEVSDDENKNLTLDNLGEVIRMSKALSARLYDIDPSLDRSLKAKRAIENVMLPYIELQREMRSKKAQTTITNFFSRRVPVIAEPADTSQQQDVEAAGTSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQY7</accession>
    <name>A0A8J5JQY7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031667">
        <property type="protein sequence ID" value="KAG7160075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQY7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="66" mass="7188" checksum="CECB839C421B94D6" modified="2022-05-25" version="1" fragment="single">MLEKSFAKDPDVGTFRPFLSQGTVEVDGVETPVTILRDSGCLQTLIKEGVVAARKTNKTSFWAPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRU3</accession>
    <name>A0A8J5JRU3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ryanodine receptor-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RyR-L2</name>
        <name evidence="3" type="ORF">Hamer_G014918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035946">
        <property type="protein sequence ID" value="KAG7158034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRU3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005790">
        <property type="term" value="C:smooth endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014808">
        <property type="term" value="P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006941">
        <property type="term" value="P:striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009460">
        <property type="entry name" value="Ryanrecept_TM4-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF8">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06459">
        <property type="entry name" value="RR_TM4-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ryanodine Receptor TM 4-6" evidence="2">
        <location>
            <begin position="507"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="613" mass="64605" checksum="0A97D9C6F25EE4E1" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSJ0</accession>
    <name>A0A8J5JSJ0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pogo transposable element-like 82</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Pogo-L82</name>
        <name evidence="2" type="ORF">Hamer_G004484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSJ0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018586">
        <property type="entry name" value="Brinker_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09607">
        <property type="entry name" value="BrkDBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brinker DNA-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="173" mass="20114" checksum="3DB2AFF5368D3599" modified="2022-05-25" version="1">MAPIVKRRRYEACFKLKVIAYAQSHNNCAASREYGVTEKMVRDWNSKEHLLRSMPRNKCAMRRGTAHWPILEKHAVDMVHEQRQNGYIVSSKHDTYLGTKWAKQNQEHSKDFKATASWCSRFMERSNLDETEAEATSSDLEFDLYDEAAINVSQDVLEELMISDVDDVDFEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTW9</accession>
    <name>A0A8J5JTW9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025502">
        <property type="protein sequence ID" value="KAG7164237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTW9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035235175" evidence="1">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="97" mass="10798" checksum="25119E1B32B047FE" modified="2022-05-25" version="1">MLAVMKCVVVLLAFVSLAWGQEQHCHCASIITTEEGAGLAYDLPPTEVQDCNNLEACELRCIDEVFLYYNLCLGPWYYTGFKSQQKLCCVGGEHTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JU37</accession>
    <name>A0A8J5JU37_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CGG triplet repeat-binding protein 1-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Cggbp1-L5</name>
        <name evidence="1" type="ORF">Hamer_G007800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7161008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JU37"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033375">
        <property type="entry name" value="Cggbp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32344">
        <property type="entry name" value="U1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32344:SF1">
        <property type="entry name" value="U1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="311" mass="34917" checksum="A851BCEACD258A8E" modified="2022-05-25" version="1" fragment="single">EFDTFTTDGSVLFCKYCEAPGTASKKFQVQQHLKTSKHIQLEAVKSNSAQKEQQLLLACSSKSGPDRSQFNADLCKAFVSTDIPLHKLNNKCLKSFLEQYTGKKGTFSNCEIFRNRSKCTTSSFTCGDKMGKLDRCCNVLWVKLRPVIATFDPEEAQSIQESKILLETEGIKESLLFIATNFACISSTITRLEERGLLLSSAISLVNGVLDELKSLQSDAYYGKLSNVLYKNKGFEKLKKVSQIMSNGAIIDETVQPLTMSDLLCMKHAPIVSCDVEMVFSEYKAMLTDNRRGFNFENLRHHVIIKCNHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JU60</accession>
    <name>A0A8J5JU60_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heme-binding protein 2-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Hebp2-L4</name>
        <name evidence="1" type="ORF">Hamer_G020744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025502">
        <property type="protein sequence ID" value="KAG7164232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JU60"/>
    <dbReference type="OrthoDB" id="6424451at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.80.10:FF:000002">
        <property type="entry name" value="Heme-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF1">
        <property type="entry name" value="HEME-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="238" mass="27299" checksum="064E50356622E5EE" modified="2022-05-25" version="1">MSAILKGIRAAFGDVEMTPYTVMVERDGYEERLYPARKWACTTMKGTSQQELVSPMFRALFNYISGKNDPNIRIDMTSPVTTYVEPGAGPTCESTFTMAFLVPEEHQLTPPLSVDKTIFIEDRPELTVLTRRFGGYTSDEIIIKEAKELAEAIKKNGETGVNFDQYYVVGYDPPFKLFSRRNEIWFVKTKESVKNQEMNEMIEKVIEIDLKEECKSVVKESEEEDKVKEEEKVQQDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUP5</accession>
    <name>A0A8J5JUP5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G003697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUP5"/>
    <dbReference type="OrthoDB" id="6378528at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="762"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7164487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="814" mass="89922" checksum="B2791F05F9B17DD9" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVN5</accession>
    <name>A0A8J5JVN5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative histidine-rich glycoprotein-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G010744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVN5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7162089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="839" mass="90078" checksum="B8620D80318F0A4C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVU6</accession>
    <name>A0A8J5JVU6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PTB domain-containing engulfment adapter protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GULP1-L</name>
        <name evidence="8" type="ORF">Hamer_G010848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ced-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVU6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043277">
        <property type="term" value="P:apoptotic cell clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01273">
        <property type="entry name" value="PTB_CED-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000118">
        <property type="entry name" value="GULP PTB domain containing engulfment adaptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF77">
        <property type="entry name" value="GULP PTB DOMAIN CONTAINING ENGULFMENT ADAPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="7">
        <location>
            <begin position="38"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7162179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="385" mass="42511" checksum="4291236B720B568C" modified="2022-05-25" version="1">MGKLTQRLKEKDNNTAAAAPATNKNWLHPPEALQKGHIAYLVKFLGSTEVDQPKGIEVVKEGIRKLKFNQQLKKAEGSKTPKVELTVSIDGVAIHEPKTKRNLHQYPLHRISYCADDKAEKRFFSFIAKEADSDKHTCFVFVSDKLAEEITLTIGQAFDLAYRRFVETSGREVEMRRQLLLLQKRVQGLEDENQTLKTRITQLATLKNRPDVEDYMKENNISDLLTLNGESSTDPEPSFEPLASSSALGPPPIPPRNTPKQDDDTALIQDILSSPLTSNGADEDDFNPRAEETLLSKVGGTNSFSSNVPPPRPVRAHEQALNNGLSDDIFDTSGDPFGSVAFSPPSNSGDALAQFIEMKAGFSRGLSFGTADDDFTLESLDPLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW17</accession>
    <name>A0A8J5JW17_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW17"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="103" mass="11518" checksum="C1A9BCDFDDBABDF1" modified="2022-05-25" version="1">MNGESSCGMSGEAAVAVRSGEQNKNAPTVLTPDFYLARAQCKHHSHQSMSSASPLCQLIEEEAEVWIIYIVIPVILMRKTLKSHYLNHRNTRQNLSLKPQVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWG3</accession>
    <name>A0A8J5JWG3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Gastrula zinc finger protein XlCGF57.1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Zg57-L1</name>
        <name evidence="12" type="ORF">Hamer_G008027</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWG3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000450">
        <property type="entry name" value="PR domain zinc finger protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056438">
        <property type="entry name" value="Znf-C2H2_CTCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23611">
        <property type="entry name" value="zf-C2H2_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7162478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="201" mass="22979" checksum="E34B955B20CA0CE7" modified="2022-05-25" version="1" fragment="single">VPQTPNRGEASSKRHQCTFCNYSTALKIDLTKHIRIHTGERPYACPYCSARFTQKESLKPHIRTHTGEKPYACFRCPYRATRKSSLRSHVFSRHNAENFKVESKKVHQNTDGSGTSNKIHRCSYCDYSTSKKINVINHTRIHTGEKPFVCAHCPAAFSQKGNLKSHIRTHTGEKPYACTKCPYRAAQRNTLMSHFISIHTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWJ4</accession>
    <name>A0A8J5JWJ4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G013099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024020">
        <property type="protein sequence ID" value="KAG7165600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWJ4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="114" mass="13056" checksum="3AEB831E92681FE9" modified="2022-05-25" version="1">MFHSTQICARHLFQADIPLHKLNNKCPKVIPGTVYWKKCLTNPTHLLELRVLKSLQVHHFLPSPVVTRWEAGSMLQRTMGKNFDVIEAVIATFDLRAQSIQESKILLETITPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXW0</accession>
    <name>A0A8J5JXW0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc finger BED domain-containing protein 5-like 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Zbed5-L27</name>
        <name evidence="1" type="ORF">Hamer_G030268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022507">
        <property type="protein sequence ID" value="KAG7166562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXW0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF19">
        <property type="entry name" value="LOW QUALITY PROTEIN: ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="107" mass="12004" checksum="57599A8A2E4D7C81" modified="2022-05-25" version="1">MAGDECFVLSPPGGLVYYEPKTISLLSLAYLVDIFEALNALNLKLQGKNINIIMHHDTIRTFMAKLDLWKCRIQQGNTASFSNLDSALIHSNLDSELKKQIITHLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYG4</accession>
    <name>A0A8J5JYG4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Usp8-L2</name>
        <name evidence="11" type="ORF">Hamer_G010464</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYG4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF46">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="689"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="519"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7166800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="960" mass="109116" checksum="493E3DBE2E11BED1" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZA2</accession>
    <name>A0A8J5JZA2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Annexin-B12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ANXB12-L</name>
        <name evidence="6" type="ORF">Hamer_G010822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZA2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF233">
        <property type="entry name" value="ANNEXIN B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0041">Annexin</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7162159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="238" mass="26538" checksum="F6CF3BAB73013FA5" modified="2022-05-25" version="1">MDTHEGTIKLKEDFDPEKPCVRFRKAMKGMGTDTNVIIKMLVTHQNIQRQEYIEKYKAMYGRDLKEDLKEELGGTFEEAVLALLEGPYDLLYGISLDEHLVSELSGDFKNLMCALVAAGRDENQTVDTPSAISDAQLLYDAGVGMNSETDEEEFIRILNTRSFPQLKEVFNQYETLAAAPIEDALGEEFSGDMKNGLLAIGEFLFMIWPEAYSTAAGEAIILYYCRSSAGEGSTGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K137</accession>
    <name>A0A8J5K137_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K137"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035293224" evidence="1">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="94" mass="10442" checksum="5CFBF73792E0E323" modified="2022-05-25" version="1">MLSVRVAFVLLVSFASLATLTDALVFCPKFPSCCYPYDTCHALCPSCREARFFRNGIRKFPKYSRPCSIGGTFINPDPFLFPGSVPFPNPPICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1J9</accession>
    <name>A0A8J5K1J9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cuticle protein 6-like 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Cu6-L14</name>
        <name evidence="4" type="ORF">Hamer_G026178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021086">
        <property type="protein sequence ID" value="KAG7167907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1J9"/>
    <dbReference type="OrthoDB" id="6376947at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF196">
        <property type="entry name" value="CUTICULAR PROTEIN 72EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035290388" evidence="3">
        <location>
            <begin position="19"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7167907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="310" mass="31977" checksum="45903B7ABDB8E1F0" modified="2022-05-25" version="1">MNPLTVVCIAAVAACSSGQLIGYPGMYGAYPGLLRAATPITLKSGTPTPIAYNMAPFAPVMPIQTKHHSQDEFGQYSFGFAGGPSSRAETRDAFGIVRGSYNYIDSDGKVQTQHYVADALGFRVSGTNLPVAPEVPEAAALAAPGPLPEPVKDTAEVAAAKVAFKSAYYEAAAASAAAPDTRAKRSVPAATTHLTPYPNMRFSYGFSAPLNYANPAIFGSAITPYAAGIPAINHAASIPSINYAAGIPATNYATGINAINYAAGIPAITSYAAGIPAITTYAAPSTATPLDAEMLRVINTPNHAVSYRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K223</accession>
    <name>A0A8J5K223_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate synthase</fullName>
            <ecNumber evidence="3">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Tyms-L</name>
        <name evidence="11" type="ORF">Hamer_G011609</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K223"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000002">
        <property type="entry name" value="Possible thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002497">
        <property type="entry name" value="PRK01827.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7168932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="252" mass="28956" checksum="450C37BEEFBD9EC1" modified="2022-05-25" version="1">MRFSLRNGDFPLLTTKRVFWRGVAEELIWFIKGSTNAKELQEKKVHIWDGNSSREFLDKSGFAKREEGDLGPVYGFQWRHFGAQYTDMHADYTGQGVDQLQQVIDTIRKNPNDRRIIMCAWNPLDLPKMALPPCHCLCQFYVANGELSCQLYQRSADMGLGVPFNIASYALLTYMVAHVTNLKPGEFVHTLGDAHVYSNHISGLNVQLKREPKPFPKLNFKRKVESINDFKYEDLELIGYNPHAKIQLDMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3Y3</accession>
    <name>A0A8J5K3Y3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SCAN domain-containing protein 3-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ZBED9-L4</name>
        <name evidence="1" type="ORF">Hamer_G005439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3Y3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF19">
        <property type="entry name" value="LOW QUALITY PROTEIN: ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="432" mass="49657" checksum="F9AC47189A382A90" modified="2022-05-25" version="1" fragment="single">MIHRQALTVKVLQADLKEVMSDVKVVDYIKDGFDLCVRRLGLNISLCCTLLSRGNVLERVFQLRTEIEIFLEEKEHNLAGKFRDSVWIALLCYLVDIFSYLKAWNTLLQGPGELVISLSEKIQAFRSKLNLLGTKLETERVAEFPNDVQDIIGQHLRSLRLRMEQYFPDIDPVSYVWVWNPFRCSTEHLPEESNGIAEEILEMKSIYAPRDMYAKIVYPENFSMNTKLRWLTDTHHTSCYNAEPDTGRNKSYAAGVRGLMTLASDWPRTPSRPQTFPSTASFLILRNGSAPTLFKLARTNSDEVTHYQLLQLNVAGSHIHLCNVHGHGQTMKHDYLLKPTDKSILYLGDFNARHPYLHDPLGRSNLNGIHTVGGTLDHVLQPNRHRRFVLGSQRGHTPLRQPRYLVSDHYVEAFVSYYDKIQFNDDLTDTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5T8</accession>
    <name>A0A8J5K5T8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Broad-complex core protein-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">br-L8</name>
        <name evidence="6" type="ORF">Hamer_G013019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5T8"/>
    <dbReference type="OrthoDB" id="6365037at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF111">
        <property type="entry name" value="LONGITUDINALS LACKING PROTEIN, ISOFORMS F_I_K_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="473"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7167545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="526" mass="57627" checksum="F075B4EDCF60AB84" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6E1</accession>
    <name>A0A8J5K6E1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multiple C2 and transmembrane domain-containing protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Mctp-L2</name>
        <name evidence="5" type="ORF">Hamer_G023390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013474">
        <property type="protein sequence ID" value="KAG7170820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6E1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04042">
        <property type="entry name" value="C2A_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF4">
        <property type="entry name" value="MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="107"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7170820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="235" mass="25777" checksum="6390078333FFCFE8" modified="2022-05-25" version="1">MMITDVSVDRQDSTTDYAADNSSAEQSSTGTPLTMSPRRGVLLASRHTSHDTSGGGTFPGGESGDQGSVPSGAHLSSLTPPTPARFRHNSQDARSHSPESETSHQQNQDPSVLRQRALRQHSFFQLHVHLKRGENLVARDACGKLLPQYSSYQSGDTARAGTSDPYVKFKVQGKLVHKSKTVYKDLNPIWDESFTVAIEDPFEPVVVKVFDYDWGLQDDFMGLASIDLATLELDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7Q1</accession>
    <name>A0A8J5K7Q1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Organic cation transporter protein-like 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Orct-L29</name>
        <name evidence="1" type="ORF">Hamer_G031117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020717">
        <property type="protein sequence ID" value="KAG7168088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7Q1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="227" mass="25385" checksum="D22FD8F67A2DB826" modified="2022-05-25" version="1" fragment="single">LTSLQTRAERLTACFATKLITRARESDVKNGLLRAVNLNRDVFNKKTRLLCAADAVSRLKLKDTILSKGLDTMSPDFSTPAPWESLPTVFNILQTGTRKADCIQNLDTVNGVGVESPDVIAANWKKKVKEESVDVRNSKQDSRNDSTFVSPFQAISYQFLGATPNYWCHVVPLVDANWTNEEILDFAIPSSSCRRKFVFIDSKVSVTALEWKTNSLPICACRGIEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8J2</accession>
    <name>A0A8J5K8J2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Malonate-semialdehyde dehydrogenase [acylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Aldh6a1-L</name>
        <name evidence="11" type="ORF">Hamer_G025696</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probable malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20804"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:20805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-oxopropanoate + NAD(+) + CoA + H2O = hydrogencarbonate + acetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76615"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:76616"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010019684">
        <property type="protein sequence ID" value="KAG7168655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8J2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="10">
        <location>
            <begin position="126"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7168655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="351" mass="38268" checksum="89F46984885664CA" modified="2022-05-25" version="1" fragment="single">LCGNVAAPTTTAPWTNSRRSLSHQLAYEEVIMATARLLHSFKGVRGLNLYRPYSSAAPNTKLLINGQFVESKTTDFIDVNNPATNEHDLAKATYQQGKTLVDAEGDVMRGLQSHETWMPTHSASRRGVCAGIAPFNFPAMIPLWMFPVALVCGNTYVFKPSERVPGATMMLTEMLMDAGCPKGVVNAIHGQHEAVNFICDHPDIRAISFGRYIYEKGSLNGKRVQSNMGAKNHGVIMPDANKESTLTQLVGAAFGAAGQRCMALSTAVFVGEANNWLPELVEKSKKLRVNADTHSQSRFGTRDIPRGSERICGLVQTGIDEGANCILDGRDIVVPGYERTEFRGADHSLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8N6</accession>
    <name>A0A8J5K8N6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger BED domain-containing protein 4-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Zbed4-L10</name>
        <name evidence="7" type="ORF">Hamer_G023581</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016606">
        <property type="protein sequence ID" value="KAG7169436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8N6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="104"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7169436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="184" mass="20537" checksum="39DD233A06CC1FFF" modified="2022-05-25" version="1">MKCIIASVFQSSTETRLNKFESMEAFHLAATLDPCYKLGWCHDYDNEVQDISDLLTVKYNMAGSVDPTATDTSPAEPPPMKRNKFVALANRSSTPRPTPPETEASLYLNQPCLQEDGDPLGNWKAKQPEFPVLARLAAKYLAIPATSSPVERLFSIAGKLFRPERCNLSDKRLGQLMMIRCNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KAK4</accession>
    <name>A0A8J5KAK4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021696">
        <property type="protein sequence ID" value="KAG7167334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KAK4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="76" mass="7970" checksum="28486601D801B539" modified="2022-05-25" version="1">MVAIQRWGRSRCWKGAKCCNQSPCAACAKRFEDGVVVGSAVTRLDYYMYGAVQWTVLGEEAAAAGAVAVAAVAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KDP8</accession>
    <name>A0A8J5KDP8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Insect cuticle protein domain-containing protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G024001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013974">
        <property type="protein sequence ID" value="KAG7170534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KDP8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035229441" evidence="3">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7170534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="96" mass="10385" checksum="E083459DAA93CD42" modified="2022-05-25" version="1">MYVLVLLAMAALVAGRPDNVLDLDLDDLHHDQSIDDDATITGTYRWTSPEGEEFFVSYIADDKGYRVVESNAVPVTADGMAANGAQGSLSSEEFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KE53</accession>
    <name>A0A8J5KE53_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proclotting enzyme-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Pce-L7</name>
        <name evidence="8" type="ORF">Hamer_G013547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KE53"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="220"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7170718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="455" mass="48469" checksum="12D9D13903F9CEE9" modified="2022-05-25" version="1">MGLDMQERLFVPGGGGVLIWAVVVMGAVSVWAESYGGMGVRLPQPLNDTVPMPVKAAGVDGRTASRDFGVITKLGEDFLRCSDRRRVEGESRKTSNKRLNTSPCGRTTTYTIVSPRTTTVGECGLSYEMGKGDAVKFILPRFTTSCEMVFKAKEGYKLSFTCSKFRASSCRNEYLFITDGVNPPIDDGGPTGTTSAEGSQIPNCSSMCGAAPSGAGATRIVGGSEADKGEYPWMVMLTIDDGGPLKGCGGAIISKRHVLTAAHCVNFRNLKLTATVGLHDMKNLNTGVSKVFKVVDFIAHPDFNSDTLANDIAVLTLEGDVNWSRRVGAVCLSPEKDYEGQMGVVSGWGTLSFQGSQPSKLQEVGVQVTNQAKCVKNYLESDIDVLDTNVCAASPGKDACQGDSGGPLVILNNGIWYQMGVVSYGVGCARPDYPGVYTRVSSYVPWILDQVSSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJP0</accession>
    <name>A0A8J5MJP0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045868">
        <property type="protein sequence ID" value="KAG7153968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJP0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="92" mass="11137" checksum="208A280997133C82" modified="2022-05-25" version="1">MKRNTLRWYEHVPRMHEDRLTKKVYDSKREENVGRGRPIATWEKRVREFFEERAGREGRVFEKASEVCKDKMAWRHFCWGVPGREQGVGNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKU1</accession>
    <name>A0A8J5MKU1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042567">
        <property type="protein sequence ID" value="KAG7155213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKU1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="465" mass="52746" checksum="390D167194BC9736" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVLKWPSHTQSVERCVKMVTEAAGHVYSHERREVITTSHHQYTSHHHKSLPTHQSSPIHLSSPQVITNIPVIMTSHHQYTSHHHKSSPQVIINTPVITASHHQRKAPRGRPTYTFSSGLQGFKSSVVQGFGGSRVRCFNGSVGQGFASGSVYKVASDRQEKVWNVLTVSDKCWQVLTTADKCWQVLTAADKCWQVLTASDKCWQVLTASDKCWQVLTTADKCWQVLTTADKCWQVLTADKCWVLTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLE2</accession>
    <name>A0A8J5MLE2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041414">
        <property type="protein sequence ID" value="KAG7155512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLE2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="61" mass="7101" checksum="7E650288553ADBBB" modified="2022-05-25" version="1">METPITERHARITVDSAYPKLLPDILWQRPITTHHNGFNVDSAHQEPITARHARIWVDYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMT8</accession>
    <name>A0A8J5MMT8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G010016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMT8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF9">
        <property type="entry name" value="ZINC FINGER PROTEIN 862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19962" checksum="ADC28E7B7B541725" modified="2022-05-25" version="1">MLTSLISSLNKRFIDMASAILQKTWILNFKLWPAEYSGNEDFGDSAVKALAQALEKTLMEAEVNPTLVEDEWTVLKSYIYKTSSADAERGFSQVKLIKTDWRSRLTDDHLTDLMVVQLQTECVGNFNPDKAIARFLTTGARHVDGCTHTAGCSTVEDLDNNNELNEEHVQEMLVQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MN48</accession>
    <name>A0A8J5MN48_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Chromodomain-helicase-DNA-binding protein Mi-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Mi-2-L</name>
        <name evidence="14" type="ORF">Hamer_G031345</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
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    </reference>
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        </subcellularLocation>
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        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="651"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="651" mass="75108" checksum="61CE1AC9A8D780A1" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNP0</accession>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
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                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7157970.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Kohn A.B."/>
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                <person name="Timp W."/>
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                <person name="Khanna P."/>
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                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160039.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRJ7</accession>
    <name>A0A8J5MRJ7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LIM domain-containing protein PLIM2a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PLIM2A-L</name>
        <name evidence="7" type="ORF">Hamer_G007741</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRJ7"/>
    <dbReference type="OrthoDB" id="25654at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09358">
        <property type="entry name" value="LIM_Mical_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="276"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7160956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="359" mass="41351" checksum="5899A0D1B1178C31" modified="2022-05-25" version="1">MEGHDNVGDMKGDAQQPQQEQLGEGSVSCIVSDQSKWEVQEENTEEQPAEEQVNQEQQAEEQVNQEHQAEEQETEVVQVKEEVEVKDQVHNKEEVNQADQEVEEQTSEGKEVAEQVDEREEVEEVDQGEELIEEVDEGEEVEVIEESELDTEDLNQIEEDQEETEKEVNHNIKDVVEEEGKQKETEERYKNWERKEQAEQKQNIKQVIPAYSTEGINDAKQKWKALEKQEDQSEVDNNKNYKIKIGQKPKDIEREPNTARAMADATKTSRFGGTSEKCAQCNRTVYAMEKMEVAGRLMHKTCFRCCKCNSPLSVGRFSVGGGHLYCLTHYKQAFREKGTYDVFTPDNPCKGKWQPKAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSC7</accession>
    <name>A0A8J5MSC7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ionotropic receptor 93a-like 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Ir93a-L15</name>
        <name evidence="11" type="ORF">Hamer_G007883</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSC7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF39">
        <property type="entry name" value="IONOTROPIC RECEPTOR 56A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="338"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7162365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="683" mass="75321" checksum="9CD9594A7C3CC8BE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTN4</accession>
    <name>A0A8J5MTN4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTN4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="221" mass="22763" checksum="06103AE9503FF33E" modified="2022-05-25" version="1">MYTTQDEGPGTTAGPGGPHTRRTTTQNTVQSLLVKSPHSPTPFCSFTPPVSSQAYNAFKVALSGRIPVALYSAKRSYRGYGDESDGVVVINFPGLGNQAGAYSADSDDFGVAVGRTSSSPIDTPSASPTASLPAVRLDDDDLADAIEDAVEDAIDTAEDAAQLTTRNAALNAFDNTAAIAAIAPRTGAGSPQLAISTEDLIDAIEDAAEEAVEGRTRSKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUD5</accession>
    <name>A0A8J5MUD5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UPF0449 protein C19orf25-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G014428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0449 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026055">
        <property type="protein sequence ID" value="KAG7163971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUD5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028227">
        <property type="entry name" value="UPF0449"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34766">
        <property type="entry name" value="UPF0449 PROTEIN C19ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34766:SF1">
        <property type="entry name" value="UPF0449 PROTEIN C19ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15136">
        <property type="entry name" value="UPF0449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7163971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="161" mass="18459" checksum="590FA652D4FE0F34" modified="2022-05-25" version="1">MILIVRFRTSEFSGAGTDIWLHCYIQSLDNISKTEKPAIMFRTKKTDFPARPQPPSWEQMEEDLKAATESDIIFTLSAGGKNTTDQPEKSATGSDAETLKDYMDDEELFQQAVEFVEKNDKLLNNIHRLTDEREELQQVSNNLKLTLENVKKQALVAIDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MV93</accession>
    <name>A0A8J5MV93_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gustavus-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gus-L</name>
        <name evidence="7" type="ORF">Hamer_G021929</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPSB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024550">
        <property type="protein sequence ID" value="KAG7165203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MV93"/>
    <dbReference type="OrthoDB" id="5547302at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03718">
        <property type="entry name" value="SOCS_SSB1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12906">
        <property type="entry name" value="SPRY_SOCS1-2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000007">
        <property type="entry name" value="SPRY domain-containing SOCS box protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF11">
        <property type="entry name" value="PROTEIN GUSTAVUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="353"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="6">
        <location>
            <begin position="541"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7165203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="596" mass="65489" checksum="43EB80A64BC5F051" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVG1</accession>
    <name>A0A8J5MVG1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SPAN-L2</name>
        <name evidence="9" type="ORF">Hamer_G004910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6 7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVG1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035336852" description="Metalloendopeptidase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="8">
        <location>
            <begin position="112"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7165126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="310" mass="34938" checksum="13F55BDD06FEFEB3" modified="2022-05-25" version="1" fragment="single">MAGKDGSHVPITNTNTLRLILTVLLLQSILTLVRARAVESVETAAAHMPLCPAHVSEDDDPKMKTLINTLPLELLNPPKIDDDKHLFEGDIVMDGQEWHYLERDNSSATTRKAIKNVARLWPVDATSGWPTIHYVMTYSVLDPLKVRDAMDVWEKSTCVKFVKISDGIHTRPFIKVKSGSGCYSFVGNMRSNAQVISLGQGCYNLGTILHELGHVLGLYHEQSRADRNDYIGINFTNVQSNMEKNFLKEKTKHYGVEYDFTSIMHYHSTAFSKNGRSTIVTKDPTKQIYLGQRSSLTFRDVNVVNQMYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW05</accession>
    <name>A0A8J5MW05_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">COP9 signalosome complex subunit 7a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Cops7a-L</name>
        <name evidence="9" type="ORF">Hamer_G005635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022531">
        <property type="protein sequence ID" value="KAG7166520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW05"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041481">
        <property type="entry name" value="CSN7_helixI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18392">
        <property type="entry name" value="CSN7a_helixI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="3"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="229"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7166520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="267" mass="29673" checksum="FEEE597D8B7D6ABA" modified="2022-05-25" version="1">MSAANMTTSDNNKTMGEKPNQTNPVEQYILLAKQAKGAAAVQLVKQVLEAPEVYVFGELLDMPNITNLKNNPQHAPYYELLQLFAYGVYGDFSRESSKFPTLTPTMLTKLRHLTIVSMATGQKSIPLVTLGTQLGLTSTRELEDLIIEAMYTGNKNGILELDHAIGRDIKPEDLPNIVATLQSWCDTCDTMLTNIDQLITRANSDKEKHLKHRNSLETEVLNIKASLKTQAQEGDEALVSDSRDHDKKRPAKKGIRASSSKFWPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWS7</accession>
    <name>A0A8J5MWS7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G011013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWS7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="86" mass="9634" checksum="C0D5284F48709D6C" modified="2022-05-25" version="1">MLGQLDERKMLRDITSVLVGGSRGLPPTLAFLFKLAWASRVRLPLLIAIGFMVTNIHLRLEINVNIEVGEEEAQPEQQPQQGEQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXI8</accession>
    <name>A0A8J5MXI8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G005408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXI8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1112" mass="124356" checksum="5F5A639CF8E49C81" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXP7</accession>
    <name>A0A8J5MXP7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Reticulocalbin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Rcn2v-L</name>
        <name evidence="15" type="ORF">Hamer_G010523</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PCSK6 (immature form including the propeptide); probably involved in the maturation and the secretion of PCSK6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXP7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000104">
        <property type="entry name" value="calumenin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF95">
        <property type="entry name" value="LD34388P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035191967" description="Reticulocalbin-3" evidence="13">
        <location>
            <begin position="23"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7166849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="383" mass="44301" checksum="E213D5EFB019237A" modified="2022-05-25" version="1">MYAWRVGLLVLVCALVWGIASAHTHHLHNAQKEREADGARSPRDHGHYVDGEHNTDFDHEAILGSAKDAEEYDQLPVSESKRRLEILLLKMDRNNDKLIERTELHSWILRSFRMLSEEESSERMDEVDEDEDGYVTWSEYISETYGITEPDDQQLLEKEDQAEEQRLLSEDRQLFNAADKNIDGRLDDKEFLAFTHPEEHPDMLPVVLQQALDEKDTNSDGVIDFQEYIGDKEQDAATDVITDREFVRDHKPKFKEMDVNNSGVLEREELGPLSSTNKHVEKFTQGKEQDREWLLTEKDKFDQEHDKDGDGILDRNEILAWVVPTNEDIAEDEVDHLFGAADDDGDDLLSFLEVLDHHDVFVGSEATDYGDHLHNLDRFEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY06</accession>
    <name>A0A8J5MY06_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G030244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020664">
        <property type="protein sequence ID" value="KAG7168098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY06"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="145" mass="16061" checksum="19B8A5984054EB09" modified="2022-05-25" version="1" fragment="single">PRFGWYDVTTRKAFSTKHSCKSSIPSPDLLATGNTMYYLHSVFFFMRGGNKVYTVLVEAVSTCLRMIGEHEFSGEVDYCLRCVVYCNQQTGILVSCGYPGSAAPWSCRRRTLLLPPSDHLCTVFLDAPMASADALLQPDYSAPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY94</accession>
    <name>A0A8J5MY94_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo-keto reductase family 1 member B1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Akr1B1-L2</name>
        <name evidence="5" type="ORF">Hamer_G012926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY94"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000006">
        <property type="entry name" value="Aldo-keto reductase family 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="52"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7167464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="350" mass="39519" checksum="0CD6E47A3D4B202E" modified="2022-05-25" version="1">MLSAASLTIGRVCYLCARLYHLSYLPQICRFSTMAPSAPSVTLNNGQTMPIIGLGTWKSKPGEVTQAVKDAIACGYRHIDGALVYGNECEVGAAIKAKIEDGTVKREDLFITSKLWNTFHSKSLVIPSLKESLSNLGLDYLDLYLIHWPLGYKENAELFPKNEDGEILYSDVDYLETWAAVEEAVDKGLVRSIGVSNFNKDQVQRILNNCRIKPAVNQVECHPYLNQTKLIEYSKSKNIYITAYSPLGSPDRPWAKPDDPLLMDDPKVVALADKYKKTSAQILIRYQIQRDVIVIPKSVTKSRIESNFQVFDFSLSDEDMKTIDTIDCNGRALHLNWVKDHKDWPFNTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYH5</accession>
    <name>A0A8J5MYH5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAAL1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SAAL1-L</name>
        <name evidence="5" type="ORF">Hamer_G002583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SAAL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYH5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052464">
        <property type="entry name" value="Synovial_Prolif_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23424:SF23">
        <property type="entry name" value="PROTEIN SAAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23424">
        <property type="entry name" value="SERUM AMYLOID A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7168503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="338" mass="37531" checksum="8849B505292880E7" modified="2022-05-25" version="1">MESQTTSLVNYNSPAGSPGVHNQLPQSTSLQPSPHINTEQIELSPRTVGILSEVPEETLKTKNPLEPVEEDTAEKSDSILELAEDVENAACQLWDMTAEPDVVDYLLGLSVVDILHLAKDIITLSRAPRLTEVVVGVVANLCCQSVGCEKVIGHRLLLNSCLTLMHTTDDVPTLIEAFRFLRLLIWHLTYRMAPQDRSQCPIMIALKSLVEGVVEVIRHFLKQWEKSSGQELPKIVHRGVLILYSFVATPAVDIISSFDRYESLLEPILVSYVEHLAKVESVDELLEGESAERLTYALGLSELLVPTMRHPNILLTVGKLLALTQEASHHYTAIHNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYZ4</accession>
    <name>A0A8J5MYZ4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G002487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYZ4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF3">
        <property type="entry name" value="MYCBP-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="201" mass="23162" checksum="4BB016C2A323F02E" modified="2022-05-25" version="1">MVDQVEETYSFLVAKETTLESAVASDMLIQIKDMINTKKAELSTRSKTSQLWINYQRMLRTARMVIRADRTGSWMMHLRAVSDCLPIFAAAGHYNYLNSAYLYVQEMCQLEARHPDVYDKFSRGFHVIRRSNQCWAGLSSDLMIEQTLMRSLKSSGGLTHGSGMTEEMRALWTMSIPITSEYNNAMQEFNDLTYTTSEQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZW4</accession>
    <name>A0A8J5MZW4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015512">
        <property type="protein sequence ID" value="KAG7169789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZW4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF1">
        <property type="entry name" value="TESMIN_TSO1-LIKE CXC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="684" mass="75956" checksum="92466D4FB4A43056" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0H7</accession>
    <name>A0A8J5N0H7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G021173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013493">
        <property type="protein sequence ID" value="KAG7170795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0H7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="160" mass="17896" checksum="DF7A3B7E96F99497" modified="2022-05-25" version="1" fragment="single">MGRCWEDVKLLCEPEVSVKEHKCVDKYDMGGLVKVAVLVTCVMGVALSLPMLQFHLGASERDSAVSLKVLRQPEKDHHTQGGADLPQEKKDYIYQEIVQTIHDQLKEEVTQDYNQVGEVDQMEYSDEVKGLLDTVGTDPADPDAVAFLLPLRGHTRYLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0K5</accession>
    <name>A0A8J5N0K5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuronal pentraxin-2-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Nptx2-L5</name>
        <name evidence="12" type="ORF">Hamer_G012504</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0K5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051360">
        <property type="entry name" value="Neuronal_Pentraxin_Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277:SF161">
        <property type="entry name" value="LAMININ G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277">
        <property type="entry name" value="PENTRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="705"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="859"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="11">
        <location>
            <begin position="25"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="10">
        <location>
            <begin position="232"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="484"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7170933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="890" mass="100665" checksum="A33EC97C6020CED8" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0M4</accession>
    <name>A0A8J5N0M4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide synthase PksN-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pksN-L</name>
        <name evidence="2" type="ORF">Hamer_G022968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014835">
        <property type="protein sequence ID" value="KAG7170212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0M4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="692" mass="77702" checksum="AB9A6B1C7CA690FF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0S7</accession>
    <name>A0A8J5N0S7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013549">
        <property type="protein sequence ID" value="KAG7170779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0S7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="377" mass="42518" checksum="3B03D47BCF7BB037" modified="2022-05-25" version="1" fragment="single">SSSVYIHTIMEESESQSGENAKGTVRPTSSTTRSATEIYLVGQPASSIRGSKLPTMRQVLKFFFHTVNESGDRQETFKETVRNVLTFWNLARIKTISERGCREKLTRLWEHWRSLQKSRDRAAKDKDIGAPDAVEDIEKNRLLTPADKQQDIAFYQDQRGERKAFMSGNDKIFAAKKRKQEERVEKQRSKQGRFAACEPSSSDSRPQTSVVADTPTEVEMEKKDTAIQPGRYTSKHPYVTVQLPRRILQEPALKELADRLRISNNEIVLVVAAVLRSANPPGDLSEFRISRETARRARASHRRQVAAAQREAFTPPPHAVVHWDGKLVKNVVGEEEHRQAIFISGRGHEEGKLLAVLPVKDGTGLTQARATARAIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1W6</accession>
    <name>A0A8J5N1W6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Box C/D snoRNA protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Zinc finger HIT domain-containing protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ZNHIT6-L</name>
        <name evidence="15" type="ORF">Hamer_G014798</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1W6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.190:FF:000001">
        <property type="entry name" value="box C/D snoRNA protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="14">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7171654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="292" mass="33505" checksum="953F98A36B4F41AA" modified="2022-05-25" version="1">MEAETLPKQQTASSKVDMCSVCGVNKAKYRCPACTVRSCSLSCVKTHKRCEGCNGVRDRAAMVLKDDMDNLSLLSDYRLLEEIDNKLEDNLRNPLRRHVMRSLKDKPSLPRFLHCLKNEAWNRGTTLKFMPSHFTSRRENTTRWHIRWVFHQADVSFTDTGVDENTPIIKLLNRYLEPKNDLSPEDNEKLEYYQSASYGKIAVLIKTDVPGSGTTFQELFVNKSLRLNLANKTVLEYPVFYVVLKDHIDAYLDYQPEGHDDLFSELPKVKGMATQKSDSLSYFDATSDMEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1Y9</accession>
    <name>A0A8J5N1Y9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger protein 768-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Znf768-L2</name>
        <name evidence="2" type="ORF">Hamer_G014814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1Y9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="164" mass="19610" checksum="19AE90A2AB75C93A" modified="2022-05-25" version="1">MEDKSDTYEDKSNTYVDKSTYEDKSNTYEDKTSLTHMKTYEDKSDTYEDKSNTYEDKSNTYEDKSTHMEDKSNIMKTRHMKTSPTHMKTNKSDTYEDKSNTYEDKSNTYEDKSDTYEDKSDTYEDKFNTYEDKSDTYEDKSDTYEDKSDTYEDKSDTYEDKSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2K5</accession>
    <name>A0A8J5N2K5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011566">
        <property type="protein sequence ID" value="KAG7172168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2K5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="418" mass="46845" checksum="82626129551B5F40" modified="2022-05-25" version="1" fragment="single">MANVGSEEGLFWSHRVLLSLQNHGERRVGGEGNLIISTLLPQCCLRSTFPLMPPFHLPTGASTPPPHWCLHSTSPLVPPLHLPTGASTPPPCFSPLALLPSSIRARRSLLLFFYNSSCPSQVPSLPSSFPPFLLPSPPLPYPPTHFSIYPPFPPSTPSINRCSSFTPPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLVTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKREEAIQREEELCQDVYHFFDSSSDEQEATSDDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGYVYSHERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N344</accession>
    <name>A0A8J5N344_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G009672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N344"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24870" checksum="E3424DD938CD5394" modified="2022-05-25" version="1">MVDNLTPGTSPPHNHKVLSVCEFWKKYIIKNAVDRTVEAWRKINVATVLHAWKSLFANSEISGAEQTVASGESQSVAATLMDTVEAARSVPAPGFSDVQVEDLQEIVGQHQQQPTTKDMLEKDEEQEVHQPTQEDYVKPGEPTARQLSELLTNIARLSEQLKEYDTRPHPWNLTCSALVKGGDDGTTNDDSELLGNFLVEELPQDFEGFDAEVRGGVDEGAGRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N366</accession>
    <name>A0A8J5N366_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription elongation factor SPT5-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Spt5-L7</name>
        <name evidence="2" type="ORF">Hamer_G025681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010984">
        <property type="protein sequence ID" value="KAG7172477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N366"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="347" mass="37999" checksum="1EBCDECE98AA7935" modified="2022-05-25" version="1">MTGDIVRVLIDERSVALKCPTPPSLRTTPPSLQCHNTTPSLQCYNTTPSLQCYNTTPSLQCYNTTPSLQCYNTTPSLQCYNTTPSLQCYNTTPSLQSTPTTPSATHTSLQCHNTTPSLQHNTTHQCYNTTPAYSAHTSLQCPHHTQPTVPQHHTQPTVHNTTPSLQCHNTTPSLQCHHTQPTVPQHHTQPTVPQHHPAYSATTPHPAYSAQHHTQPTVPQHHTQPTVPTTPPSLQCHNTTPSLQCHNTTPSLQYHNTPSLQCHNTTQPTVPQHHTQPTVPNTTQSTVPQHHPAYSPTTPHPAYSATTPHPAYSATPHPAYSAPTPHSAYSATAPHPAYSATTPHIWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3H5</accession>
    <name>A0A8J5N3H5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Alcohol dehydrogenase transcription factor Myb/SANT-like-containing protein 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G020106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010583">
        <property type="protein sequence ID" value="KAG7172551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3H5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF8">
        <property type="entry name" value="DPT-YFP REPRESSOR BY OVEREXPRESSION, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="16"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="296" mass="33437" checksum="5FE164C9A81A9C69" modified="2022-05-25" version="1" fragment="single">MSQPTKLQWRREDVMQLIELYKENNCLWQVKSEKYKDRNARDIALLKIVEHLKDNLPQVTVFDVKTKLHTLRSQFCRELRLIREFKKSGSEGTEKKSKTKLWCFNDMMFLHDGEETLESVSTLGVQPDEIPVDDDDDDDDGDDDDDDLPPQNPTTTTEPSSSHTTTPAPTLSPPLPMISHSRSPSPTPSTSDKPAKRKRKVDKTDELIAMAVSRLSESVKEPDEFKAFGIVVGSQLKTMDKYQAIVARKLINDILFTGSLNKLEATSQIVSACSNINVPVTQLNHIKVVPRSGCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N517</accession>
    <name>A0A8J5N517_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G020135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009549">
        <property type="protein sequence ID" value="KAG7173512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N517"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="94" mass="10917" checksum="98FE34842ACCE623" modified="2022-05-25" version="1">MDTFRQNDLIPYRNIHNLMRKFLDQDLNPASMDELEVPSCPSRHCGRPGNVVECKWSLFQITIWSAAEDFTLARTSFDPFHLTIQKLSVLSHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5V3</accession>
    <name>A0A8J5N5V3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Serine/threonine-protein kinase Genghis Khan-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gek-L2</name>
        <name evidence="2" type="ORF">Hamer_G017974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009070">
        <property type="protein sequence ID" value="KAG7173689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5V3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="216" mass="24367" checksum="A9C48B4CF9C3C8D7" modified="2022-05-25" version="1">MGPGDSIEIQRLVDLPSRISTAADQRTQHTQSIHRVRSMLQTSGKLAPPRLPQGPEPPRRSFSHQPLPQPHYSNVHNGPMEPNFSIPIVEISRVSILPLLHIAPVVDLHQCLALYVGQECLPYRPPQLHSTCLHNAHQKNLVIRLFINYKSKSVEIPHHVTPLPPTPVVISPLHLHLVDPPTTTHRPMTHRDTSGLVRDYEQVPHRLADMGCQFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6F9</accession>
    <name>A0A8J5N6F9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G021545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008528">
        <property type="protein sequence ID" value="KAG7173929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6F9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="89" mass="9886" checksum="A31071E6E3552770" modified="2022-05-25" version="1">MSHTKITGQGLSDRRITKNISQRITTTLGEGRCLYTLPQAPHTTTHTLYGTIRTARGENSCRTVDESRMRVLLTAREGRNPVCGRTVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N914</accession>
    <name>A0A8J5N914_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative pol-like 38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pol-L38</name>
        <name evidence="1" type="ORF">Hamer_G026276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003812">
        <property type="protein sequence ID" value="KAG7176196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N914"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="404" mass="45895" checksum="556F3CC32B0F86BA" modified="2022-05-25" version="1" fragment="single">EDIDQLNQDLTGAIQHAGEKAIPKTNPTNRHHKDYWFYNDEVREQNHRINTFRRHLRQYPSPEGVKLLRAAVQHACQITQKIREDKWLEWFATFNAHTSLSELWRKLRIATGKLPRSPAHPQPLQEANRLAEHFAECSSSAQLPPEIRLHLQHVQMEREVVVRHAIEQVDITDCLFTIDEIRRSRKTRKDTASGSDGIIYSLLSNGGLSGELALITVINTSWSAGKLPSAWKGANIVPIRKPNYPRISDQYHQQHACKLDHFTTISLDSPKWAKLEVAQNNAMRAIVKAPMCTKIENLHMETGLTSLQTRAERLIACFATKLITRAQEGDIKNGLLRALNLNRDVFNKKKRLLCAADAVNRLKLKDTILSKGPDTMSPEYSTPAPWESPPAVFNILQTGTRKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N964</accession>
    <name>A0A8J5N964_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N964"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="64" mass="6982" checksum="2DABD7863C796546" modified="2022-05-25" version="1">MGEDGSAYTATHGVNGASDALQRQAFTLKLFKIDKMLMSWGSIPKRPTTKDPLLYGPPLPGFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9K2</accession>
    <name>A0A8J5N9K2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G029925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005377">
        <property type="protein sequence ID" value="KAG7175597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9K2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="82" mass="9527" checksum="C0B215FF9FEF2FEA" modified="2022-05-25" version="1">MIWAARRHLHIAPMLTSEDEALGRWMSRLSREIHTDVCHKVRRLMASWTPRLTKERVNKATQSASDRDGADIHSVSIQKLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9K4</accession>
    <name>A0A8J5N9K4_HOMAM</name>
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        <submittedName>
            <fullName evidence="4">U-scoloptoxin(01)-Er1a-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G001494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9K4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF40">
        <property type="entry name" value="CUTICULAR PROTEIN ANALOGOUS TO PERITROPHINS 1-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035232297" evidence="2">
        <location>
            <begin position="32"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="95"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="540"/>
        </location>
    </feature>
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        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
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            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
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            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7175408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="540" mass="61570" checksum="E276FD6ADCC9E0D3" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAG0</accession>
    <name>A0A8J5NAG0_HOMAM</name>
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        <submittedName>
            <fullName evidence="5">Transient receptor potential-gamma protein-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G023336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003299">
        <property type="protein sequence ID" value="KAG7176485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAG0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23650">
        <property type="entry name" value="TRP_CaM_bind1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
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        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
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        </location>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7176485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="423" mass="45474" checksum="798AAA7ACF4B320C" modified="2022-05-25" version="1">MKERADTEWKFARSKLWISFFEEGGTCPPPFNTIPTPKSLYYLLHWFYKKFCGQTKAAKKEHMRTIRSIMRNLVRRYVTVEQRKAENQGVTEDDVNEIKQDISAFRCELVEILKISGMNTSTATTSGQGIHPRGSSGGKKNRQKERRLMKGFNLGVNTLSTTQSLGATTVLPATAEVRAGSQKKVVEVAVKRSPQNKLARLARLAEARLGRPTNKKRWGTLVEAAKNAKVKKLLSRSRSDESLSSEPGNEITGNSEDALGGGGETPTPLQNLPPGILRGPDGSSEATRQERTGSGVSGTMHLDAAALVSQHEPVKRPPKSSVSFDQSALAGASSSSPSHSSTETEPPPPYPQWPRPVSTSSNVTEPTVTAASPSSGSGSLPPLAVSESSEPLVGAGPPANGSVQPPRLPGIQPVNRHMAAGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAH2</accession>
    <name>A0A8J5NAH2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cuticle protein AMP3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Cua3-L</name>
        <name evidence="3" type="ORF">Hamer_G009790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAH2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
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        <location>
            <position position="217"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="217" mass="24087" checksum="4E418D1A266462F9" modified="2022-05-25" version="1" fragment="single">SLRRFYINLRQQCIREASGIECPIVCVLSFVCGGGGIWEDVYKFIYCTIVTIVTIVTSPRHQRHHQHSSITVTHCKDTKKHVTREVVLVVVLVAGVLADKKPLVDPPVAILHSEQHHPDVTGAHSFDFEAENGIKLHVSGSQGENGGANSIGYWSYPLEDGSVASLKFVADEFGYQPQSDLLPVAPEFPHPIPDFVLRQIAFAEAQRAQQSREDYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAN3</accession>
    <name>A0A8J5NAN3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pro-resilin-like 107</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G017040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7176068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6346814at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
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    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
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    <keyword evidence="4" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035278849" evidence="4">
        <location>
            <begin position="18"/>
            <end position="140"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
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        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
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        <location>
            <begin position="47"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7176068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="140" mass="14086" checksum="10020C52BCDB0D32" modified="2022-05-25" version="1">MKTVILMLVVVSTAVWAGPQGYGSQGGGGGGGGGGGSGGQDFAPPQYNFQWDVNDSPSGNFYGHKEERDNDDTRGSYYVQLPDGRRLVVDYFVDQWGYHPTVTYEGEATFPSGGGGGGGGGGGGGGGGGGGGGSQQGYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAP1</accession>
    <name>A0A8J5NAP1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oleosin-B6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G009918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAP1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="358" mass="38785" checksum="3F6815396B8532B2" modified="2022-05-25" version="1" fragment="single">METEEASINAAQGVCQARTGLVLSTSRLGLFPPQWPYRRLSQLVLSELVGVSAPEDKGRDEDVRLPVGVDGVGWTLGSGLTPLSRWSRQAVHCQPGDDACKRCSSSCSSVEPSHLPECCEAYNSCCDEYFQACKKCSSLVSKDLFFPEYCCASFTDCCHLITTFTTAIKPPEPVKISTKNQLKVPTVAAPKPSVFPGLKPSQTADLKPLKASSSQSFFESQAPLPSAQDFSVLDTPGAPAFQPSDSRVPLFESPAPQTPVFQPQAPRAPVVQSPARGSRQRAPSPGRAQARPHQRQQGRRRPTEPSGFLAIAGIFFQLAFMYWLPETHLTSQVSPSSIPPVPSTDDVFRAAVQCTCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCK8</accession>
    <name>A0A8J5NCK8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCK8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="86" mass="8768" checksum="C096794C7BAFBF24" modified="2022-05-25" version="1">MPPILNPQTSLVVAEAHMGEAGTSHTPHLSSTSHPGTARISAKRNRGSSESLEMSAKAGASSSEMPTDPLPEVSGDETQTKIGAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NFN3</accession>
    <name>A0A8J5NFN3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027972</name>
        <name evidence="3" type="ORF">Hamer_G028618</name>
        <name evidence="4" type="ORF">Hamer_G029941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039699">
        <property type="protein sequence ID" value="KAG7156171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010026212">
        <property type="protein sequence ID" value="KAG7163810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010001032">
        <property type="protein sequence ID" value="KAG7177928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NFN3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7163810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7177928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="138" mass="16133" checksum="F726CC21F6943DAD" modified="2022-05-25" version="1">MMLMKKNEDRRRADDPGIMKFKSELSLTMKFYKNTVFKDMAAAKKGKTQAEQDAIDTDILFMKSMLSDRVATYSGVNKVLKEKVQERQKRQMREEKRQEREQCDHVENVQADIDSPISSDEDDDIDEASTAEPKRKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T5H9</accession>
    <name>A0A8J5T5H9_HOMAM</name>
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            <fullName evidence="5">Serine/arginine repetitive matrix protein 2</fullName>
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    </protein>
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        <name evidence="3" type="ORF">Hamer_G007063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="851"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1208"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="380"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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            <end position="574"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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    </feature>
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    </feature>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="1288"/>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1305" mass="143368" checksum="7E89A66409EF823E" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T6Z3</accession>
    <name>A0A8J5T6Z3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cuticle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G025913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009687">
        <property type="protein sequence ID" value="KAG7173489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF230">
        <property type="entry name" value="CUTICULAR PROTEIN 47EE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035197794" evidence="3">
        <location>
            <begin position="17"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7173489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="164" mass="17334" checksum="234E134B7AA5CA78" modified="2022-05-25" version="1">MFSKLVLCVLLAVVAAKPQEGYGAPQQSYTSSGSVVPIVKDERQGPDADGNYNFEFETGDGISRQEQGAPHGETGAVAAQGGWASPAEDSVSHTHFFFRFKFPDGSPGVFNFVADAAGYKVQSDLLPTPHPLPAHAIQQIEFARQQEAAGPGPQYGAPPSPGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TEY9</accession>
    <name>A0A8J5TEY9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposable element P transposase-like RNase H C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003057</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">American lobster</name>
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            <taxon>Pleocyemata</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TEY9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
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        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="119" mass="12942" checksum="FD6938576EECEF99" modified="2022-05-25" version="1">MGGCNNDPTARQFSAAYKKVLTRNDTEEVTRGNCLALESIPIPTAFSNYLKDLNVNAPLSKLINSSLDISRAFEQDNIYQYKESVVLSEEGNTNLVSSSVVSPCAEKIVAFIAGFVSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5THY3</accession>
    <name>A0A8J5THY3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Integrase zinc binding domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011388">
        <property type="protein sequence ID" value="KAG7172398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5THY3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="186" mass="21438" checksum="458EC21BBAA3F4A6" modified="2022-05-25" version="1">MHNNPASGHQGVKKTLSLLQQGFYWVGMRKDVPFMRRLLRQEGTKATHAKTTRRNHQLRQKPQERLAEVNHQVRGALEFSSGVMKCNYDVKASQVCYKDGDKDRLYNPLRKKDVIYRIRGGGKAQPKVDHANRLRQYHGLEQYTWEDSEEQLLTTDEDQTWGNPTIDQEEEHHSLLAKLGVTGEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJW2</accession>
    <name>A0A8J5TJW2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Troponin T-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Tnnt-L</name>
        <name evidence="4" type="ORF">Hamer_G024033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the troponin T family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009989">
        <property type="protein sequence ID" value="KAG7173342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJW2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.350:FF:000003">
        <property type="entry name" value="Troponin T isoform 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027707">
        <property type="entry name" value="TNNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521:SF1">
        <property type="entry name" value="TROPONIN T, SKELETAL MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7173342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="343" mass="40607" checksum="7EFFF5EF729AF016" modified="2022-05-25" version="1">METTKMSDDESAYSASEGEEGEEHQTQQVREEILRAEEEKKLTEQKRSEEDRKMREETERKQREQEEKRKRLEEAEKKRQSMMKGSSDGVKKFGSKGGDKLSNIQAAKGELGKTREQLAEEKKIALSIRVKPLNVDGIGSSSLRCKADEMWNLIIKLETEKYDMEERMKRQDYDFPFSSSLSLSHSLEVRIYKLKELRERQKQQLRQKALKKGLDPEALTGKHPPKIQTASKFERRTDRRTYDDKKKLFEGGWDVVHKEVLQKLWESKYEEYMSRNKSKLPKWFGERPGKKANEPESPQEEEVEEELEPPPPPEPEEEEEEEEEEEEEEEEEEEEEEEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TMJ3</accession>
    <name>A0A8J5TMJ3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF885 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TMJ3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361:SF2">
        <property type="entry name" value="DUF885 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="GLR0591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="63364" checksum="148CD85CB1C89B67" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TNJ4</accession>
    <name>A0A8J5TNJ4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Wnt inhibitory factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Wif1-L</name>
        <name evidence="7" type="ORF">Hamer_G016938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7175983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TNJ4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070697">
        <property type="term" value="F:activin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038100">
        <property type="term" value="F:nodal binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038092">
        <property type="term" value="P:nodal signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF54">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="228"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="495"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7175983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="670" mass="72668" checksum="B476FCF24DD6FAC3" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TNR9</accession>
    <name>A0A8J5TNR9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Homeodomain-like domain-containing protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G030704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004041">
        <property type="protein sequence ID" value="KAG7176148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TNR9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="2">
        <location>
            <begin position="11"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7176148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="8040" checksum="301F98916F7D2C33" modified="2022-05-25" version="1" fragment="single">GKELGRDTIVAIITPYKEGYKCKDIATRVGIGVRQVQKWIKKFRDGGEKLARCIPQRLEKVIKLRGKSLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J7A8</accession>
    <name>A0A8J5J7A8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Chitin binding Peritrophin-A domain-containing protein 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G010558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J7A8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF42">
        <property type="entry name" value="FI18455P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="118" mass="13566" checksum="0841A0F3B50BAADC" modified="2022-05-25" version="1">MQIKRNIISSLGNTSGCRRVLGTSEGLECWQGHRMPASLCYRGRPRRRRGGYYADPETRCQAFHICQFERDTKVLCPNGTLFDQEKFNCIWWNAVDCSLTESFYELNKNIGVVPPDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J7D4</accession>
    <name>A0A8J5J7D4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bestrophin-2-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Best2-L5</name>
        <name evidence="8" type="ORF">Hamer_G009305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J7D4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF0">
        <property type="entry name" value="BESTROPHIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="547"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="877"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="905"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7153646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="919" mass="103813" checksum="E8476DCB3E5B8340" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J8J2</accession>
    <name>A0A8J5J8J2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox protein aristaless-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">al-L</name>
        <name evidence="9" type="ORF">Hamer_G020495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045000">
        <property type="protein sequence ID" value="KAG7154186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J8J2"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="164"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="166"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="514"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7154186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="563" mass="61864" checksum="C74F38AEDAB2A79F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JC32</accession>
    <name>A0A8J5JC32_HOMAM</name>
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        <submittedName>
            <fullName evidence="5">Putative Tigger transposable element-derived protein 1-like 256</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIGD1-L256</name>
        <name evidence="5" type="ORF">Hamer_G028356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040361">
        <property type="protein sequence ID" value="KAG7155802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JC32"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035226502" evidence="3">
        <location>
            <begin position="23"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="HTH psq-type" evidence="4">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7155802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="202" mass="22355" checksum="5CB012C0A27080E1" modified="2022-05-25" version="1" fragment="single">TSAKPRGQQSLIFNFCWWFITSTYITMPPKRPAAPSGSTPKRARRVLTPNEKNEVLKQLDSGMSYAAVGRHFGLNESSALSARLYDIDPSLDRSLKAKRAIENVMLPYIELQREMRSKKAQTTITNFFSRRVPAIAEPAGILQQEAEAADTSQQQDVEAADTSQQQDVEAAGTSQQQDAVPAHTPQEDADLDSSYSSDWSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCT2</accession>
    <name>A0A8J5JCT2_HOMAM</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040175">
        <property type="protein sequence ID" value="KAG7156057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCT2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="56" mass="5925" checksum="06342A7C24890EB7" modified="2022-05-25" version="1" fragment="single">MFMHLTSQDPLYETLESLCLVITSKVTGLANSADVALSGGETLIHSIMADVDNGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCY1</accession>
    <name>A0A8J5JCY1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040031">
        <property type="protein sequence ID" value="KAG7156117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCY1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="120" mass="12945" checksum="871A1DDB00903879" modified="2022-05-25" version="1">MVAIQRWGRSRCCNQSPCAACAKRFEDGVVVGSAVTRLQKGWTTTCRIGVFGMVSGSDGGRASGYSATEMGAKGGASGVGYVPRGKSKEGDDQVLCIYLGGYEEDVLRRKEEARRRRSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDN6</accession>
    <name>A0A8J5JDN6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G030978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040920">
        <property type="protein sequence ID" value="KAG7155701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDN6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="94" mass="10296" checksum="80F738F2A90764B3" modified="2022-05-25" version="1" fragment="single">RTSKDRTVDVIDVVAERASILRPDTLKSSSEELRRSGTTCTSRCRVNARLLLRRRASSSEATPTGSPAPTVRSVSVRLGSLVCNRNERITPTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFJ6</accession>
    <name>A0A8J5JFJ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glutamate receptor-like 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Glrk-L17</name>
        <name evidence="15" type="ORF">Hamer_G006136</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFJ6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7156391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="459" mass="51003" checksum="DE33B52208249DE7" modified="2022-05-25" version="1">MSIPARALLRIAAEEWVPWTKIDVQENGTVGILGPMAHLLDIFADKLNFDYELVRPSDRVWGGPQSDGSWTGMLGMLQRQEVEFAIGPFGVTALRETVCDFSDPVYSENNAILMVRPTLQNDFTGFVKPFTIKTWVWTLVSLVTVVVMMALVVKAEARVFTSQTRHVLSKAAMWGVKTLTQESSEWLPKNDGGRLIVTTWLLASLVFMTSYGGILTAMLTVPRVTIPINSLADLVSQTDLPWRLEAGSMMFQYFKESQDEVRQKVFTEVAGTFPDCWAARKAIANGEFAAICDRTTMKKAMSWDFSTSGQCHLYISSENVYSNAIISMAFKNNSTYLSDANRIIRTVKESGILDKWLAAEITNTTQCLRPPTSDRGNAVAALNVDVMAGPFLVLVGGDTSDAEDTGDKEIQGYIDSVTTLSPPHSTTRRRNCFTKLLDPSEHRFKTSFPSDYETSFPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JH47</accession>
    <name>A0A8J5JH47_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing RING finger protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PDZRN4-L</name>
        <name evidence="3" type="ORF">Hamer_G025132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037353">
        <property type="protein sequence ID" value="KAG7157590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JH47"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051971">
        <property type="entry name" value="E3_ubiquitin-PDZ_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545">
        <property type="entry name" value="PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545:SF8">
        <property type="entry name" value="SLO-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="13"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7157590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="774" mass="86428" checksum="C2B4BEDCDE3ECF0E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHU7</accession>
    <name>A0A8J5JHU7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G020598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034522">
        <property type="protein sequence ID" value="KAG7158582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHU7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="231" mass="26157" checksum="938CCD9B6BA791A6" modified="2022-05-25" version="1">MVALLVVSCLAGCGYWRRRKIYESSASQTLGHAHAYATPTPSDDTPMYGPPLPFLPPTPYPAPPPYSEAARPSFDPLEQHLYDAMLAGHSVYDFYDRRHPNAYYDRYFLPDDTSSSETTSLLSYRLHRSCSAHLPRHHSLRKCDMLAPPPYSEVAAKPELYPVVVMRQGIAEVNSTKSMTEAAGLTHHHHAWHPPCHHYIYRSDSVLWIRVDSESVQWRRPARSSRGSGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JII5</accession>
    <name>A0A8J5JII5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolar complex protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Noc2l-L</name>
        <name evidence="5" type="ORF">Hamer_G009399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JII5"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="708"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="740"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="785"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="810"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7153729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="829" mass="95122" checksum="ED2604BCAE43E77B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ67</accession>
    <name>A0A8J5JJ67_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Sodium/calcium exchanger 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">Slc8a3-L</name>
        <name evidence="22" type="ORF">Hamer_G004080</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJ67"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032452">
        <property type="entry name" value="Na_Ca_Ex_C-exten"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF76">
        <property type="entry name" value="CALX-BETA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16494">
        <property type="entry name" value="Na_Ca_ex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01259">
        <property type="entry name" value="NACAEXCHNGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="21">
        <location>
            <begin position="147"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="21">
        <location>
            <begin position="251"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG7159452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="618" mass="67534" checksum="3C130F07BCDD901E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKK6</accession>
    <name>A0A8J5JKK6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G010061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKK6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="420" mass="47283" checksum="37B514B1B88E2711" modified="2022-05-25" version="1">MNMLKSLKVTLVVKDFLQCQKTARHHPQFKYWSLVLELELTVLMFVRSLKSSNFKLCVDALVQLMPWFFALDRTHHSRWLSVHVHDMQELPVKHPQLTREFEAGKFTLPKTKHAFSTIPLDQSHEQNNEMVKGEGGATGLTGNPQALRRWKIEGPQIATLVNEFEEKTHLNAEEQLHEQVPSFQRCQNHGGSLHDFFAHENQAYPPISAGGRLQTSSKSHLLKCFEKLCEARTGEPDISAVVIGGAGVVQMLKPGRTKIFKEADCSRVDKFVSKGKKIFLKAPSRCDVFKKIAPQLALPPQPILTRWGTWISAVLYYASNLDKFQDILTSLDDKDSSAIHIVKELLQDRLLCNDLAFIASNYGNLPEAINTLGKSNMPLIDALKCFETIVADITQVSGEKGKSVSEKCERVIAANRDLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKN1</accession>
    <name>A0A8J5JKN1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033121">
        <property type="protein sequence ID" value="KAG7159405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKN1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="275" mass="31245" checksum="BEC3DA481BEF9370" modified="2022-05-25" version="1" fragment="single">MTFYHVLLSSFLRPLDARLSEEPVCPLLYLEVVFVLDKELINDMIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLALEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKRTNPREGTKEENEEKVPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKN5</accession>
    <name>A0A8J5JKN5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tigger transposable element-derived protein 1-like 175</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TIGD1-L175</name>
        <name evidence="1" type="ORF">Hamer_G010081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKN5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="177" mass="19711" checksum="90FDCF744AE3DF4B" modified="2022-05-25" version="1">MEGSHAKLHECSVEESVAECVHDFSDFTDIIAIHPDIASISQEAGLQDVDEDNVAEVLDSHSEKLSTEDLLLLEQQQRGESTGEEENPAPMMLTMKVLSTSIGHLNTAMELLAENDPNINRSLSVRAVVEDMLCYKEVYSESINTCPEVHTQYNTCNQPRHYHKSVFGNVYSSKLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JL13</accession>
    <name>A0A8J5JL13_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G018792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036987">
        <property type="protein sequence ID" value="KAG7157724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JL13"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="87" mass="10271" checksum="B8593DEBB86C3E23" modified="2022-05-25" version="1" fragment="single">MERKDCPEKLEKRHWEMKKKKGERDRDCEIQGGMDKQAGREGCIIQEVHNAKMETFNKFICVSISQLAVVLGPVKQRYLKRDMTFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JM96</accession>
    <name>A0A8J5JM96_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2505"/>
            <end position="2542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2519"/>
            <end position="2538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="3031" mass="340119" checksum="131599680638024E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMD1</accession>
    <name>A0A8J5JMD1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative vegetative cell wall protein gp1-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040627">
        <property type="protein sequence ID" value="KAG7155769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMD1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="495" mass="55792" checksum="CB70DBBA35D48ACC" modified="2022-05-25" version="1">MTSSPVVCLIGETEPFTSPHSPSSLLHLTVSPSLPPTPHSESYPHSPPHSESFLSYTTHESFPHSYTSQQRPSLIPSHHTESFLHSYYLTSIRKSYTILQIFLSLLHNIPSPSLTPTQHTKSIPHSYPTYQVLPSIIHNTTSPSLTPTQYYKSFPHSYTILQVLPSLLHITTSPSFTPTQYYKSFLHSYTTYHVHPSRLHNTTSPSLTPTQHTKSIPHAYTILQVFPSLLHNTTSPSLTPTPHFKSFPHSYTTLQVLPSLIHNTTSPSLTRTPHYKSFPHSYTTLQVLPSLIHHTTSPSLTPTPHYKSFPNSYTTLQALPLLLHHTTSLSLTPTQHYKSFRHSYTTLQVLPSLIHNTRSPSLNPTQHYKSVPHSYTTLQVLFSLLHNFASPSLTHTPHYKSFPQSYTTLQVRPSLIHDATSPFLSPTQLCKSFPHSYTILQVFPSPLHNTASPSVTPTQHCKSFSHFYTTPQVLPSLIHNTTQPCKAFSLYFTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMK2</accession>
    <name>A0A8J5JMK2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase APD1-4 middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G006229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMK2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032010">
        <property type="entry name" value="APD1-4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032008">
        <property type="entry name" value="APD1-4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39077">
        <property type="entry name" value="DUF4793 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39077:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE APD1-4 MIDDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16041">
        <property type="entry name" value="APD1-4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16040">
        <property type="entry name" value="APD1-4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="775"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase APD1-4 N-terminal" evidence="3">
        <location>
            <begin position="290"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase APD1-4 middle" evidence="4">
        <location>
            <begin position="688"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7158861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="90677" checksum="14B7238500C860D6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNF0</accession>
    <name>A0A8J5JNF0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNF0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="359" mass="38738" checksum="616C4A177B704C8E" modified="2022-05-25" version="1">MNIVGRETGRGRNIIGVKDMSLGEGHGSWGRTWFVGKDMGRGDGHGSWGDTTTHPGAASVWWWSSREVLGSPHAPRHLTHTHSSPVTDTVAAAATSRRFFHWESASKPALNRCGYRSTSPHHPTAAAAVLPHLHHGHYPCPHHHHLRHHHRARRRHFTGESPPWPRRSSEVSPPSIASSWHTDTSSLLTSDSFSGGSSTLSADGTNITTDTLFVSHNALLSAARMSSTGAPRSTMEGNGGTSTAAAREVKQYLNRTLFPRPSSTLHGYASLYHRLKKLPGSHRKTRQQGKASPTSGSDSGSGGLRQDDQGGSDMDDVDIVEDKLHSPPRIEIHIYVPTAAATTAAATAPPHEEDSAIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNV3</accession>
    <name>A0A8J5JNV3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G014844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010035946">
        <property type="protein sequence ID" value="KAG7157978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNV3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="3">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7157978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="201" mass="22925" checksum="B3840A1053148B03" modified="2022-05-25" version="1">MVKTKALHRGKVWWPTINKDVEKAIRQCIPCASLETRKQANPVNLSEMKGPWEVIHVDICGPFPRGDYVLGIIAAGSRWPEAFVVKSNNTDTEHPSLDDGRDASQTPHGKEHQGETPQVNHDLEDTQVTCWDVARKRDKREKEKLKLRTDNRNKSKLAELRPTDQVLLKQTKKDKLSTNYDPKPWTVSERRGDSDTALHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPP9</accession>
    <name>A0A8J5JPP9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thymidine kinase 2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Tk2-L1</name>
        <name evidence="2" type="ORF">Hamer_G007400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPP9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF38">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="1">
        <location>
            <begin position="155"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="307" mass="34876" checksum="CDCF217F34E51141" modified="2022-05-25" version="1">MKWRDCWEVLVNMHNAGTQYLAGNIPKRRAPNRMCSKVLTESTIKVAVTEDSSMEFLEGCSLDESTTRKLLVDSHLSPPKRNFHSRSIMSSSKTGMSPLPASLILQKSFGFIASEMPSEMKMRSRPFTVSIEGNIGSGKSTFLQYFSATPGVATHQSYVQLTRLNIHLQQSSSPVKLIERSLQNNRYCFLESGHDCGHLKEPEYSVLCEYYDLLESKLDIGIDLIVYLRTTPEVVHSRMMKRGRSEEADVPLKYLKVVHSYYEKWLLNHLPCAPPAPVLVIDANQELEEVRKEYDLKKPVIMGEKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQF5</accession>
    <name>A0A8J5JQF5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G005724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQF5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="120" mass="13097" checksum="5CD4C4911F3758A2" modified="2022-05-25" version="1">MVLLAADGAHRGYRKIFTRAVDTNVVVLYIVFNTKIGCECLWVGFGTGWSCYLYVTRMAEVLGEESCSALPAFHALTSSFAEKVRTKVIPLHVQPSSASLTLLDTTADGLVALRPTFKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQG9</accession>
    <name>A0A8J5JQG9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G016639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQG9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="87" mass="9628" checksum="13E9C2745A6D9156" modified="2022-05-25" version="1" fragment="single">ASIVSGRHQLIGYLRQLIGYLRQLIGYLRQLIGYLRQLIADWLPASADWLPASADWLPASADWLPASADWLPASADWLPASSLPDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JS16</accession>
    <name>A0A8J5JS16_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G008754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JS16"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="491" mass="54179" checksum="CF3E07A47F095EE5" modified="2022-05-25" version="1">MLPWTTCHPPLSVMIFTTITTNTRTTRHNLTLVKSDDLPPPTPATPVDPGTPMAPPTPLSSSGGLEPTLQVLDQLPVSQGLPVSLSSSLSVGLDMSYKHYRHAELTPVSQEHCLPGQLDDSEASMGLDPMGESGHLSPRNDHLADQLPLPELQPHDFRRLPALRSPEPPRSPYLSPSPTPDALRSYLVTTDGLRSPVPLDQCVDMTRANLFLRPADLASLQQRYHGEVGHQSGRAQLYELERVPSHSVDLSVTGRTLTYTSEALRPGSVCTTVYVADSHPDDRHSLDLTLPRHDPDLHRLNSPIHNHPANRGMSPHSQLSPHNQLSPNNQLSPHNQLSPHNQLSPHNQLSPHTQLPPYSQLSPHGQMSPLVNLGMVERGGMCSPHSPQLTPHYLPLAASWLLHLTHHYLPRDKCLQYQDLSCHHPSPPTPMGRCLLQGVLCPFNPVPQGPRSPQPLRVARIDPLPTHSTLPPHTLVIITIPPTPTYHYQYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JT72</accession>
    <name>A0A8J5JT72_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cuticle protein 18.6-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Cu186-L1</name>
        <name evidence="3" type="ORF">Hamer_G030650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026262">
        <property type="protein sequence ID" value="KAG7163801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JT72"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7163801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="215" mass="24206" checksum="C3B2FED1E9C74CCD" modified="2022-05-25" version="1" fragment="single">DPENMWAYEVDARSTGDKKSAREERRGDVVVGQYSAMDPDGSLCVVDYSVAPDTDFQATPKPIAPAKAQPVPESTDPPRPVPEPTEQPQPVSEPTEPPQPVAEPTEPPRPVPETTELPRPAQNQQSQLRGQFQNQLSTLSRPIPEPNPSTPTVPNPQSRPDQFQNQLSTSDQFQNQQSRRDQFQNQQSRPDQFQSQQNRPDQFQNQLSTRDQFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTA0</accession>
    <name>A0A8J5JTA0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Armadillo repeat-containing protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Armc7-L</name>
        <name evidence="1" type="ORF">Hamer_G011477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTA0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042462">
        <property type="entry name" value="ARMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263:SF1">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="155" mass="17031" checksum="AD023F862020BA75" modified="2022-05-25" version="1">MPISLFSEAREEVLANLANFAYDPINYEWLRKLKIIDIFLNQLSEGTPTLCSFAVSGLCNLSLDQENKSYIIKNDGVALIRGCLSSPEESTVISAIVTLMFLVTPQSKAVVGNCFGTPRKSHTIQGDPDPYSNNTSLGFTSTVEYFLSRVISAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTV0</accession>
    <name>A0A8J5JTV0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leukocyte receptor cluster member 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Leng9-L</name>
        <name evidence="4" type="ORF">Hamer_G007345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTV0"/>
    <dbReference type="OrthoDB" id="10263155at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042653">
        <property type="entry name" value="Leng9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46729">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46729:SF1">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7161710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="448" mass="51071" checksum="9C3F75B2BA51244D" modified="2022-05-25" version="1">MSFEDLVTDPCRAVNKLETEEATTATCDENTVMENVCSHYLEGKCRFGDDCFNLHPPNVEVKKVTTTKHSTQNQNKSAKNTRKVPPEVENEKKKPLKTAGDVRKRIQWDPELQKEYFTVGYLDRFIGVVEKPYTAFSWEHLSMVDLDQLAVPQHRIQYYKYKGTKVWDKNERLDHVFGSAGNGITIQQVIREVDAEIEKNTQTFDSDEDSSDDELIVLGGVSNSGRGLISNICEGQGPKEVFLRATHFFCIKVKNDQVKSTAAKVQEYVVQGEPVLRSCVMPNELLHVTLAMVRIETPEAMTEAVNILNDLQGRIEKLLGPTPEDVEENPERIIRVRGLSTFGARVLYTKLQVPSSFTVIVDMLYEALRRVDGITVTNHFGFVPHMTLLKINRPTARERRSKYFNSSLYSDYLECDFGTIVFNNVHFCCIEDLRGPDGFYVTCRKIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUB0</accession>
    <name>A0A8J5JUB0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027662">
        <property type="protein sequence ID" value="KAG7162596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUB0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="259" mass="29319" checksum="0D13884D3D9E561D" modified="2022-05-25" version="1">MATQGDIVTMEPNVQAIMVAELSLGEIRDHLPPNRVHTELKKGKQPTNTAVFIGWLISTGSYKVVDGTPQLKVMLREVNPTEEMGSALEVMFHEDLALGVDEHLKKIQEDQWLMIWGYRQESSLYVGMEGSVRIFYVPSHTSPLPYRNIITIWECRLEMKKRMLYGVVREVVKHPQITKIGSHHTLLSLVDPTCLHPGADQDDIILHIFINDPGKVKLRGTVERGQIIRTLLTLALKNAYAFGICKKYQRKGPVEEATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUQ8</accession>
    <name>A0A8J5JUQ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045600">
        <property type="term" value="P:positive regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034450">
        <property type="entry name" value="ADIRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39227">
        <property type="entry name" value="ADIPOGENESIS REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39227:SF1">
        <property type="entry name" value="ADIPOGENESIS REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1521" mass="166317" checksum="35BBBA00587E16B1" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUS0</accession>
    <name>A0A8J5JUS0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab GTPase-activating protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Rabgap1-L</name>
        <name evidence="4" type="ORF">Hamer_G004981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUS0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="195"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="761"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="531"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="762"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7164596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="789" mass="89552" checksum="95082E916E512B1D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWH2</accession>
    <name>A0A8J5JWH2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Hamer_G020874</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023275">
        <property type="protein sequence ID" value="KAG7165842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWH2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7165842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="230" mass="24506" checksum="EE241630F2C16AA0" modified="2022-05-25" version="1">MSGGMEGHESPVSSILDTIIGSQQTELLEMLHVPVLHTGVNEVLLLSSFTTNSPGALAFACFLLVIFAILLEVLRLLLWWAENKFMTGGETARASCDCKHCTSLTVSLPGAGDRKNYSAIHDTQDSTESSNTLTTQPSPMSSSIRHMFLGTAGLLQFVIHVASLLFMLIAMTMNVYIILSLGVGSALGKVITIIARKILLEKCQAVGSGDDNGHGAPAGPMLTRSCDKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXE7</accession>
    <name>A0A8J5JXE7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NPC1-like intracellular cholesterol transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Npc1l1-L</name>
        <name evidence="4" type="ORF">Hamer_G014237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025553">
        <property type="protein sequence ID" value="KAG7164111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXE7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF130">
        <property type="entry name" value="PATCHED DOMAIN-CONTAINING PROTEIN 3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="529"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="3">
        <location>
            <begin position="326"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7164111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="640" mass="72623" checksum="BEC3705DAECED361" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXI0</accession>
    <name>A0A8J5JXI0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Negative elongation factor D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TH1-L</name>
        <name evidence="8" type="ORF">Hamer_G020824</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NELF-D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026066">
        <property type="protein sequence ID" value="KAG7163908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXI0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006942">
        <property type="entry name" value="TH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04858">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7163908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="571" mass="64630" checksum="DCF6CE8D641618ED" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JY70</accession>
    <name>A0A8J5JY70_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G004382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JY70"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="156" mass="17673" checksum="6A85069A09CB54B6" modified="2022-05-25" version="1" fragment="single">LLAATFGLKRIPVSRGINGRAKFTNALFSFKCTKVTSKVTSHMRPKRRRMPLDSKFIRQKEAKELYDKVSKGDDHGVEFPTAEPQLRNIITIAKMKLEVKGFSDDLTADREDEVSDDENKNLTLDNLGEIIRMVKGPLCFRLYDIDPSRGSLKAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYE0</accession>
    <name>A0A8J5JYE0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7165886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYE0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="767" mass="87362" checksum="1497D83AAE555FB2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZD6</accession>
    <name>A0A8J5JZD6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G010461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZD6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="154" mass="18007" checksum="11AF91164953592C" modified="2022-05-25" version="1" fragment="single">MNRQLVELRPVTPDPTVGWHINLLRFVYINLLRFVYINLLRFVYFNQVRFVCIMKVVYISTWYINQLGFAKIKQLCCDKINQLTFVHVNRGRSLYLNGSSFLLQKSSSSFLLQKSSWSFLFQGSSSFLLQKSSSSFLLQKSSRSFLLQGSCCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0R2</accession>
    <name>A0A8J5K0R2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fantom-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RPGRIP1L-L</name>
        <name evidence="3" type="ORF">Hamer_G019654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024921">
        <property type="protein sequence ID" value="KAG7164815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0R2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031139">
        <property type="entry name" value="RPGRIP1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240:SF1">
        <property type="entry name" value="PROTEIN FANTOM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240">
        <property type="entry name" value="RETINITIS PIGMENTOSA GTPASE REGULATOR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7164815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="484" mass="56233" checksum="4082A4272D37A715" modified="2022-05-25" version="1" fragment="single">MSTSDDYQVPVRDGHAIHPKYTAPEEMYWLSHLNQEDLCEKYVGLRDDFYTLKKFSCKQEDKIKKLQTKLRKFIADRKKVDMTKGSTSFSTQEIEYQDALETHRHSIRDLQLKNDHLEKKLKLASIQLSTAKKNKPLLFRHVGPRVDSGRKQIRTSVTPQVRQPPQPSSSPSKPVHQPDPVLPEKIREILEEARGRILSLEAERDDLQEELIEKQQAYEDAEYDLQQEIAMMKDELQDRGVREENDSVAVVCAERKTRTLSARNTALHEQLVITEEKVEAERTRKEALQNELERITGKLLLIENQLRELQQEHQNTNENSHLQKENERLTSLNLTFEKRGLASENESLKSQIAQLESALQSDLIERGTFLEHMNSDKEALAKVEVEVKTLRERNIKLQEDLEETSRKLNIFSKAGLLDLTEEDLTSSLKKQKEDASHNISLKEFEEAKHKHSELQLLYREKTLELERITATLTTHSETYKALQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0W1</accession>
    <name>A0A8J5K0W1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TCF3 fusion partner-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TFPT-L</name>
        <name evidence="6" type="ORF">Hamer_G023243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021789">
        <property type="protein sequence ID" value="KAG7167311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0W1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097190">
        <property type="term" value="P:apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033555">
        <property type="entry name" value="TFPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35084">
        <property type="entry name" value="TCF3 FUSION PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35084:SF1">
        <property type="entry name" value="TCF3 FUSION PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="144"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="144"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7167311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="210" mass="24237" checksum="4CF85FE69C15752E" modified="2022-05-25" version="1" fragment="single">MMFSGAGEDVDNTAHEGNIMPAFTLVENGTEDKYYKKYNAILRRCSSIQKENEMLVNRVYQVKKIVRRLRKERKFLMEELDKRGDNYRSLPLTIAIEEEEKSFALPQTSSLPALGRPRSTSSSSSVKRQLQVKREKPERDPTAPKRPSNAFLQFCQEQRDTTTAQYLQQTGRPLDKKHLTKLLAARWSSLSEDDKKVRNSLSNISCPHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0X9</accession>
    <name>A0A8J5K0X9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0X9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="969" mass="110408" checksum="04824C3E2A066CBA" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K129</accession>
    <name>A0A8J5K129_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Acid ceramidase</fullName>
            <ecNumber evidence="6">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ASAH1-L2</name>
        <name evidence="21" type="ORF">Hamer_G011100</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the acid ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="6"/>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K129"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016699">
        <property type="entry name" value="Acid_ceramidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029130">
        <property type="entry name" value="Acid_ceramidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583">
        <property type="entry name" value="ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583:SF1">
        <property type="entry name" value="ACID CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15508">
        <property type="entry name" value="NAAA-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017632">
        <property type="entry name" value="Acid_ceramidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0458">Lysosome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035317882" description="Acid ceramidase" evidence="18">
        <location>
            <begin position="18"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Acid ceramidase N-terminal" evidence="20">
        <location>
            <begin position="40"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Choloylglycine hydrolase/NAAA C-terminal" evidence="19">
        <location>
            <begin position="136"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017632-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF15508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG7166271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="362" mass="41329" checksum="97C5DDE3108A50D8" modified="2022-05-25" version="1">MNLQTFIFFVLLSYTHAKFSFTDPFESCETNAFPPKQSDAAPRYIINLDLPPQERWTKLVTEKKNDVLALIGDIRNLTLSLVGEKVFKVIIDNLDKIATTLPYPFNEEIIGISKASGLNISEATLYNIFYEVFTFCTSIVAQDTSGHLYHGRNLDFGLFMGWNPKTHTWTIAELLKPLVVQLEWQKGGKTGLFTFSLDERFGLNGGFVGLLEWVSFLTREVMEEAKTYKEAKFMLSHTRLLAPVYFILGGVKSGEGSIITRWRDNFHTDDLLDRMSGSGSWFLVETNYDQWKTPPFFDDRRTPAVHCLNKGGQKNASPKLLYNVLSTRPVLNKLTTYTSLMDVNRGTLGAWLRKCEDPCWPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K166</accession>
    <name>A0A8J5K166_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cuticle protein 6-like 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Cu6-L11</name>
        <name evidence="5" type="ORF">Hamer_G019067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021370">
        <property type="protein sequence ID" value="KAG7167667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K166"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF196">
        <property type="entry name" value="CUTICULAR PROTEIN 72EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035302034" evidence="4">
        <location>
            <begin position="17"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7167667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="393" mass="41344" checksum="92490AFD68097E1C" modified="2022-05-25" version="1">MTCVLVLLLVWCACWCQPTTVVSFSPVGYSPGVAPGFAYAFRAPAPLYSPAATPTGRSLLSRAFSNSIGAPAPVPTIIKTQYHSQDELGQYAFGYVGDASTAHEVRTMDGAVRGSYTYVDSDGELQTANYVADRNGFRVEASNLPQVPVAPTVAVVPLPEPVKHTPEVEAATAAHLRAFAEVKAARAKRAIPSTSYLPPPPPPVHLSSGEPVEEEPRHVPALTNVLVPPTYTVKASGPPVPVAISTPAVHHPHPLPTPSAPVFIPPPSLPAPSHIANTHAVFIKADPQDLHHVARVPLPTSLAAALASPGPVVAPQVLTQFHSQNELGGFEYGYGGGPSSKHEIHTPDGVTRGSYSYIDANGALQTVSYVADDVYGFRVLASNLPEAPADPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2Q8</accession>
    <name>A0A8J5K2Q8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hemocyte protein-glutamine gamma-glutamyltransferase-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Tgmh-L2</name>
        <name evidence="5" type="ORF">Hamer_G011231</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="3">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2Q8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.260.10:FF:000002">
        <property type="entry name" value="Erythrocyte membrane protein band 4.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000090">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050779">
        <property type="entry name" value="Transglutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023608">
        <property type="entry name" value="Transglutaminase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008958">
        <property type="entry name" value="Transglutaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590:SF40">
        <property type="entry name" value="HEMOCYTE PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00927">
        <property type="entry name" value="Transglut_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000459">
        <property type="entry name" value="TGM_EBP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="4">
        <location>
            <begin position="301"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7166394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="725" mass="82439" checksum="BDE130872B8E2A30" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K369</accession>
    <name>A0A8J5K369_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transposable element Hobo transposase-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HOBOT-L2</name>
        <name evidence="6" type="ORF">Hamer_G002420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K369"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7168391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="241" mass="26942" checksum="BA89F658D0C98812" modified="2022-05-25" version="1" fragment="single">STQVTEDYSGLPAQHIPCFAHMLQLVIKDGLKNATQLNRILDKTAKIVSYVRRSTVATELLEGENRVEAANVTRWNSQVKMVRSVLALPEDKFSLLKEDVTLLGAYEKNMLQDIVQEATDYAQRQNTVSASKVVTRVRGPRQRLEQRKSKYNNNFVAALKSSPGKRLTQYEASKQFGVAAVPDPHFKARWCQDHMEKTDLTAEFTAQITANCGMLAAPVNASSPPKKRCKIASFMEDPDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4F4</accession>
    <name>A0A8J5K4F4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022112">
        <property type="protein sequence ID" value="KAG7166885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4F4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="243" mass="27153" checksum="053B6591DEFCFFA8" modified="2022-05-25" version="1" fragment="single">SMESTRSKTEVWLIGQHITEITVAQLPSRGDVLRLFFHGHNEHKKTVNDSAREVAASVISFWNKARIPTITEKSIGRKVVDLFLMWKGLKKNCTRTTDTQRKKEETFCDELEDLFDVAHPKAMQLLTIKEDRAFLAAQREKGRRGVMAGVDKKIACSIKRREESKSKQSLQQNQASSALEYDELGSSSETESQSSSSSSTSSLAISPVVSSSNRKRATLKVITPELSSTLDRTGISHRSALRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K590</accession>
    <name>A0A8J5K590_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeobox protein XHOX-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">xhox3-L</name>
        <name evidence="7" type="ORF">Hamer_G020869</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015974">
        <property type="protein sequence ID" value="KAG7169557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K590"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052002">
        <property type="entry name" value="Even-skipped_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46294">
        <property type="entry name" value="SEGMENTATION PROTEIN EVEN-SKIPPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46294:SF4">
        <property type="entry name" value="SEGMENTATION PROTEIN EVEN-SKIPPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="3">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7169557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="349" mass="37714" checksum="1577EF1E30E6D662" modified="2022-05-25" version="1">MQPFRVSPEMLDGLEDKLQLLGGHRVPVSPPCSPPAPSITPPSPTPSPAIQDENSNIKKDIPIGATTPIISEPQQKIQQPEASSCSGGQSAAELRRYRTAFTREQIGRLEKDFLRENYISRPRRCELAQELGLPEATIKVWFQNRRMKDKRQRLALTWPYADPALTAYLLHAAAASGVYPPYLSPSFTPVSPWAAAAAQFGGPPPPAYTSSQLRFTPYPRPHPASILSPPYAMPSDVPIPPTSVMAPSPVMPRPSGHLPSCPARDSPKLGGDGCLCGLFYPSLAHSLTPTLPSPPAHLPSTASDSVHSPVPVNNDTAGRCSPVNRPATSPQRKAPPRSLFKPYRDDLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5N6</accession>
    <name>A0A8J5K5N6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inactive serine/threonine-protein kinase TEX14-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TEX14-L</name>
        <name evidence="4" type="ORF">Hamer_G016845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020459">
        <property type="protein sequence ID" value="KAG7168206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5N6"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043063">
        <property type="term" value="P:intercellular bridge organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mitotic sister chromatid separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039339">
        <property type="entry name" value="Tex14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23060:SF3">
        <property type="entry name" value="TESTIS EXPRESSED 14, INTERCELLULAR BRIDGE FORMING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23060">
        <property type="entry name" value="TESTIS EXPRESSED GENE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="217"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="736"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="787"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="836"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="886"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="840"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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            <begin position="1039"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7168206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1051" mass="113673" checksum="CB66AE7843365701" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6C2</accession>
    <name>A0A8J5K6C2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Shootin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SHTN1-L</name>
        <name evidence="3" type="ORF">Hamer_G016172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014436">
        <property type="protein sequence ID" value="KAG7170356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6C2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044295">
        <property type="term" value="C:axonal growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031252">
        <property type="term" value="C:cell leading edge"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001224">
        <property type="term" value="P:positive regulation of neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024849">
        <property type="entry name" value="Shootin-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46606">
        <property type="entry name" value="SHOOTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46606:SF5">
        <property type="entry name" value="SHOOTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        <location>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
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            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <end position="280"/>
        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="374"/>
        </location>
    </feature>
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            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="527"/>
        </location>
    </feature>
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        <location>
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            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="657" mass="72448" checksum="B18000B6595F4104" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6F3</accession>
    <name>A0A8J5K6F3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028113</name>
        <name evidence="3" type="ORF">Hamer_G030458</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019764">
        <property type="protein sequence ID" value="KAG7168641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010015340">
        <property type="protein sequence ID" value="KAG7169826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6F3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7169826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="112" mass="12788" checksum="EBF16C2F392AC602" modified="2022-05-25" version="1">MTYKEVLDVVAYANSSLSWLELVDLDEKERNKPTQVTKQPQPKPQNGPVMSYSHLLKDKVQPQTTTQEEPKVVEAIKGPQLAPKPQRIPRKRGNRGSVVRKPRSHNYTTREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KF15</accession>
    <name>A0A8J5KF15_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G012558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KF15"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="120" mass="12842" checksum="6F530D8069A77667" modified="2022-05-25" version="1">MAAADEYSTTSHVLQLCLALQDRLEKVEKEVQSLKGENLALKLVLEEKKTLASVVKDGEVEVDSWKVVAASATKCTIKRHSAVDLNNRFSTLSDECEEGASNTTSATPSVSVERGSSAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KH08</accession>
    <name>A0A8J5KH08_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trypsin-1-like 11</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Trypsin-1-like 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Tryp1-L13</name>
        <name evidence="7" type="synonym">Tryp1-L11</name>
        <name evidence="7" type="ORF">Hamer_G018127</name>
        <name evidence="6" type="ORF">Hamer_G027686</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014214">
        <property type="protein sequence ID" value="KAG7170425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010008733">
        <property type="protein sequence ID" value="KAG7173850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KH08"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000118">
        <property type="entry name" value="Chymotrypsinogen A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="81"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7170425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7173850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="420" mass="44111" checksum="6D0F8630F9B1805A" modified="2022-05-25" version="1">MRTQYSLGRSPCYFVSCGEHTLEPGTSVGIQSKNFPNNTPTAIIVCGPSGKVQTITQVTTDVTDISVDNAKCGTVNRVTRIVGGVATEVNEYPWQAALVVKGTNQVFCGASLYNDGYVVTAAHCGSVLLGAHELTSSTSAQQRISVERIINHESYDSSTQDNDIAVLKLATKASLNENVKPACLPSVSEDYTGFTATVSGWGTLSSGGSQPDVLQEVQVPVVSNSECQQSYGNSISDMLCAGYDAGGKDSCQGDSGGLAVRRMASGCWQVWCHGAMGVLCPTTQESTFGSLVKYLDWLKAKTSEGSNDLCFSGQGSGSTTKTPAATTVPSATSCKCGQATDRLVSWVVSQLRYTSIPDKWLSSVLPAQHHSVAPPSSVTSGSSLLLTALPCKSPGLSILCWVTTLIKTSFLVISNILIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MF41</accession>
    <name>A0A8J5MF41_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047204">
        <property type="protein sequence ID" value="KAG7153261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MF41"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="281" mass="31252" checksum="E9E7A6CD99D23140" modified="2022-05-25" version="1">MASTSGSGTKPKTRKDNEVWLIGPTAHALTALAQKTKEDEKQGMNPPFSSSSESEEQVNSSASECSPPKKSKPGKPRAKNIMSPVLAKALDRTKISDRDAVHLIAAAAQTLGHNVEDIAVNRKTIRQSRMKLRVQSFKSAKEQFILNLDPTIPLVVHWDGKLLPETAGGKETYDRLPIIVSYEENEQLLNVSKLPNGTVVPIFWQTNAGYCKAQKKLKTMKVVNDVAERGVALIQDYIHVITKDEEQRQFLLQVVSDHRKNFPNSLKRTVIEALKKNDLCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMK4</accession>
    <name>A0A8J5MMK4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Inner centromere protein B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">incenp-b-L</name>
        <name evidence="10" type="ORF">Hamer_G030665</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038829">
        <property type="protein sequence ID" value="KAG7156785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMK4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990385">
        <property type="term" value="C:meiotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051257">
        <property type="term" value="P:meiotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051310">
        <property type="term" value="P:metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7156785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="221" mass="24863" checksum="DB9B36589C1BBC3B" modified="2022-05-25" version="1" fragment="single">EQNKEHAGGVCHLWCLVAQAIKIAEVERIAREKKELEYLKLLEAQRIAELQQAKLTSSAVKKIALADNKETGLNHTFTLSDNKENGLNTTFSKTTGPSQSSSTGKNKDSYDITPNSKKYKKNINNYDINDIESDDSTDEDSAPKRKIPPWAMIAALGHNDYNAERSRIAVRGVKSFLAPYEQLLCERRKTAKQQTLDVFFKSTSKKQTEDTEPQPSTSEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNA9</accession>
    <name>A0A8J5MNA9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DPH3-L</name>
        <name evidence="9" type="ORF">Hamer_G020366</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036764">
        <property type="protein sequence ID" value="KAG7157823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNA9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="8">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7157823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="83" mass="9579" checksum="BBCC80AB6C68A278" modified="2022-05-25" version="1">MSVYHDEIEIEDFDFDEETETYYYPCPCGDRFQITKEELTSGEDAATCPSCSLIVRVIYNVEDFAEYEEESVTVSQEKPLATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNB3</accession>
    <name>A0A8J5MNB3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sperm acrosomal protein-1-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Spaca1-L7</name>
        <name evidence="2" type="ORF">Hamer_G027469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036737">
        <property type="protein sequence ID" value="KAG7157838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNB3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="127" mass="13804" checksum="0692DAA670DB5BCB" modified="2022-05-25" version="1">MAQHNTAQHNTAQHNTAQHSTTQHSTAQHSTAQTTAQHNTTQHITGQHSSIQDNTAQHSTTQHSTAQQSTAQHNTAQQSTAQHNTAQHSIAQHSTAQHSTAQHSTTQHNTDHRRLLVLAVMNMPAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MP25</accession>
    <name>A0A8J5MP25_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeotic protein empty spiracles-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ems-L</name>
        <name evidence="10" type="ORF">Hamer_G021112</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMX homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034714">
        <property type="protein sequence ID" value="KAG7158539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MP25"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000081">
        <property type="entry name" value="Empty spiracles homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050877">
        <property type="entry name" value="EMX-VAX-Noto_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339:SF28">
        <property type="entry name" value="E5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="222"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="224"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7158539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="325" mass="36583" checksum="969A37E4369EA6A3" modified="2022-05-25" version="1">MMPQAPTPVVPTRPRLGFSIESLVGCGDEKRRSASPPAPGFTKLPESPPHHSPREVGSLALPREFLLVREQQLREQLRDQLLKEQLFRVQQARQEPYQPPSPLTSPVRAHSPNTQVDEDKKESSPLTSPVSLPPPSFLQGSGVHLPPHLLSLGGHTMPHLPAPLMPHPLLAQGQVPQLGTPLPPSPRDYPLYPWLLSPRHGRIFPPGFPGGHDFPTFLLPFRKPKRIRTAFSPSQLLKLEQAFEKNQYVVGAERKQLAQTLNLSETQVKVWFQNRRTKHKRQQQEDEGGEGGERKSEDKQSEEEGLVLEHEEDEELDVENEAETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPG2</accession>
    <name>A0A8J5MPG2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPG2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="119" mass="12986" checksum="FCF57A9962C5A703" modified="2022-05-25" version="1">MCSALDKGMEEYNALYMSLVNAHQQALITRYLCKAQPVHALTNITLGDDDGTTDDDIKVLGDLLVEELPQVFEGFDAEVREDVEEGAGGSSNHPSLPWNPSTSPVKHFTDSINVSYSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPL7</accession>
    <name>A0A8J5MPL7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication termination factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Replication termination factor 2 domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RTF2-L</name>
        <name evidence="5" type="ORF">Hamer_G023168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033882">
        <property type="protein sequence ID" value="KAG7159081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPL7"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7159081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="299" mass="33218" checksum="43A4A1F1550D7974" modified="2022-05-25" version="1">MGCDGGTIPRRDELVKTKKKPEQKDKNSERLYRWRHCSISQTPLKKPIVACEIGRMYNKEEVLTRLLDRSAEPGMSHIKGLKDIKELNLTPNPGYIHEGANKGDAYTDHQAAEFICPVTSLEMNGKYHFSFVWRCGCVVSERALKEVKSDVCHKCGQPYQEEDVIPLNPSEEEHDAVKARMLSRRALAKAAKKAKKEGKRSADGEDNDASTSSSSKGKKAVKLSDGASSSSDCSKSSLRVNGMASAVLRDKDFKNVRSAGFSVASDPKASEVYKSLFDTHKTAQKKQSAHWVTCNPQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPR7</accession>
    <name>A0A8J5MPR7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPR7"/>
    <dbReference type="OrthoDB" id="6373200at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035296134" evidence="1">
        <location>
            <begin position="28"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="146" mass="16411" checksum="EC09BCDC5773ED2D" modified="2022-05-25" version="1">MLVLILLLTSKMKFLVILCSLTVLTWAQEVPECDCGAFITESAEEEEVFPMEAFDVENCEDQKDCHDRCRTEWNEITSEGDLNFELPDGKTVGQSMCDDLAEEGKDVVGPTEVFLYVRLCDGPWEDDGEATKEMLCCDAGQHEPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQH1</accession>
    <name>A0A8J5MQH1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">thioredoxin-disulfide reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TXNRD1-L</name>
        <name evidence="17" type="ORF">Hamer_G017480</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7160028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQH1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000093">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000004">
        <property type="entry name" value="Thioredoxin reductase 1, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000012">
        <property type="entry name" value="Thioredoxin reductase 1, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006338">
        <property type="entry name" value="Thioredoxin/glutathione_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01438">
        <property type="entry name" value="TGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF8">
        <property type="entry name" value="THIOREDOXIN-DISULFIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="14">
        <location>
            <begin position="107"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="16">
        <location>
            <begin position="213"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="15">
        <location>
            <begin position="486"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7160028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="613" mass="67314" checksum="7E97A9C78F922D1F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQZ9</accession>
    <name>A0A8J5MQZ9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Circumsporozoite-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CS-L8</name>
        <name evidence="3" type="ORF">Hamer_G023002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030986">
        <property type="protein sequence ID" value="KAG7160703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQZ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7160703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="517" mass="51379" checksum="BC9D3D511C87E286" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSI3</accession>
    <name>A0A8J5MSI3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSI3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="145" mass="16324" checksum="8F025193ADE84FBA" modified="2022-05-25" version="1">MDKGRLPCGVSSPQGHVKRSLMGGPSLTFYTCRVSTEPQYKSRHRNIKENPFVSFHHMRWNHDPHTANFVWKCTATVTLSLETTVTLEPRCIDIGGTNRAGVVLLWLVLTATEATLSQLGNLYIVTPVHYETDPHAAYRFNNVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MT24</accession>
    <name>A0A8J5MT24_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytosolic Fe-S cluster assembly factor CFD1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CFD1-L</name>
        <name evidence="7" type="ORF">Hamer_G029846</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027010">
        <property type="protein sequence ID" value="KAG7162818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MT24"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF21">
        <property type="entry name" value="NUCLEOTIDE BINDING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7162818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="195" mass="21154" checksum="C65C3BFA6A1AD617" modified="2022-05-25" version="1" fragment="single">GGILPYFAAESYRLLGQNPTVFWGRILPSSGAESYRLLAQNPTVFWGRILPYSGADSYLILGGILPYSGVDSYLILGGILPYSGIESYHLLWRNPTVFWGEILPSGTESSPHGNIKTLSVGSLLSSGAQAIVWRGPRKTALIRRMIKDTLWGRLDDLIIDTPPGTSDEHLTVIKLLATTKPDGAVIVTSPQMLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTB1</accession>
    <name>A0A8J5MTB1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proton-coupled folate transporter-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Slc46a1-L2</name>
        <name evidence="6" type="ORF">Hamer_G002194</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTB1"/>
    <dbReference type="OrthoDB" id="419734at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7163118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="541" mass="60075" checksum="89969F86CE455026" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTE3</accession>
    <name>A0A8J5MTE3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate--CoA ligase [ADP/GDP-forming] subunit alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Hamer_G004342</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTE3"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="8">
        <location>
            <begin position="22"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7163238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="292" mass="30158" checksum="FB71E22D852501D4" modified="2022-05-25" version="1" fragment="single">SFTGVAPIGTRSCYAVSRPNLAINEHTKVICQGFTGKQGTFHSRQAIEYGTLMVGGVSPGKGGKKHLNLPVFNSVAEAKANTGADASVIYVPPPGAAKAILEAVEAEIGLIVCITEGIPQQDMVKCKIGIMPGHIHKKGCIGIVSRSGTLTYEAVHQTTQVGLGQTLCVGIGGDPFNGTNFVDCLETFLRCPDTKGIIVIGEIGGGAEEAAAEYLKTHNTGDGAKPVVSFIAGLTAPPGRRMGHAGAIISGGKGGAEDKIKALENAGVIVSRSPAQMGSMLLEEMKRMHLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTN1</accession>
    <name>A0A8J5MTN1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein light chain 1- cytoplasmic-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ctp-L</name>
        <name evidence="2" type="ORF">Hamer_G002138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTN1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="125" mass="13823" checksum="2D4A1689F74C1294" modified="2022-05-25" version="1">MSKPCWNDTNTYCLRMSSDRKAVVKNADMSEEMQQDAVDCATQAIEKFNIEKVRSWSCGLLYQGGKCLIILHMGKRIGVWLSSGFTLAFCSLALPVHPFVNGYQCLQLLGSAALALLPPCVLKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU07</accession>
    <name>A0A8J5MU07_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Chst11-L2</name>
        <name evidence="10" type="ORF">Hamer_G002057</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU07"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7163009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="210" mass="25299" checksum="50FD493F15E63F37" modified="2022-05-25" version="1">MSSSTTRFMVVRHPFERVLSCYRDKYLNGTKSYYYLNIGEKIVRRYRKFPPEFNRQQGQVRNKIKKNLPVVLKDNPYANPVGPTFSEFVQYIIYAHYDDEHWRTYNAHCSPCYVPYEFILRFESLKEEGKLFLDYLNRTSDIKPRWENPTYGSSTSEVACSYFNQISVKLLQNLYQKYEKDFKLYEYMPDAYFKCAQDYNHVNNNTVLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUT1</accession>
    <name>A0A8J5MUT1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HAUS augmin-like complex subunit 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HAUS6-L</name>
        <name evidence="4" type="ORF">Hamer_G014248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025553">
        <property type="protein sequence ID" value="KAG7164122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUT1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026797">
        <property type="entry name" value="HAUS_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028163">
        <property type="entry name" value="HAUS_6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16151">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16151:SF2">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14661">
        <property type="entry name" value="HAUS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035300448" evidence="2">
        <location>
            <begin position="30"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="domain" description="HAUS augmin-like complex subunit 6 N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7164122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1118" mass="124294" checksum="3F414B16A458EAC9" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW12</accession>
    <name>A0A8J5MW12_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G011792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7165893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW12"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="122" mass="13733" checksum="E90E576CAA74C35F" modified="2022-05-25" version="1">MLKAMTGPKVGAGHVVLSTLYIHAIRSLTYFATPALNTLSEWQWEKLEVAPNNAERVNVKAPLRTKIKDLHMETGFTSLQTRTERLTACFATKLISRARESDIKNGLLRALKLNRDVLNKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW55</accession>
    <name>A0A8J5MW55_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G011772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7165876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW55"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF1">
        <property type="entry name" value="TESMIN_TSO1-LIKE CXC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="208" mass="23192" checksum="1849A8ABE19C2BCC" modified="2022-05-25" version="1" fragment="single">HSEEATEFKAGKFTAQKTKKVFFSIPNDKANEHNDALIKGDVGVVCLTDNSSAICRWMIAGPEVSRVIEEFQDGNRHRERRADTCNHDQTASVENAFDKDVHSFANLIEDLRNPIEEGYVDLVSSSQEITGPVAIKAIRKPYAPATTSIFLDGAAIIQMLKPAADKNFNEYASQIFIPYLSRMLQNLHRLEIVSVGVLQMQEGFCDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWT8</accession>
    <name>A0A8J5MWT8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tumor suppressor candidate 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Tusc2-L</name>
        <name evidence="1" type="ORF">Hamer_G010479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWT8"/>
    <dbReference type="OrthoDB" id="9025707at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051881">
        <property type="term" value="P:regulation of mitochondrial membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029393">
        <property type="entry name" value="FUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15453">
        <property type="entry name" value="TUMOR SUPPRESSOR CANDIDATE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15453:SF8">
        <property type="entry name" value="TUMOR SUPPRESSOR CANDIDATE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15000">
        <property type="entry name" value="TUSC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="100" mass="11465" checksum="B5CBD8C14AF84FF0" modified="2022-05-25" version="1">MGGSTSKLKRWMSNGTEDPEQCERAVKKLASPFVYTRRGSMYFDEDGDVAHEFYEEVPPLKRGVKATMKRILINLTPQGEVRLPFPCLHVDFPIILYQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYM4</accession>
    <name>A0A8J5MYM4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G018389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7167959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYM4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7167959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="323" mass="34313" checksum="3FAFD1D36B265F08" modified="2022-05-25" version="1" fragment="single">VDVDPSVGVDPSVGVDPSVGVDLSVGVDPSVDVDLSVGVDPSVDVDPSVDVDPSVDPSVDVDLSVDPSVDVDPSVGVDPSVGVDPSVGVGLRVEVNTMRVINSGQPQTNVDPVDEGHGELWDGRATRFNNRDERTNVQTVNSDRPPPAYPCQEVCIQCGKKVTEADNDADVTITQRGPESGPGCPCECHKQLQSDKLTEAVDQVSQGHIPPAGPRCLPGCGYSGLPCYNCSLLQEHLEPEGTTTSSQSQTFSPQIYTIELMEPPSGSNTQGSGSRHRDNATENTMLARNRKRTCFSIVAFVIAINVVVGIFRMLMGTRNHYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZ88</accession>
    <name>A0A8J5MZ88_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">V-type proton ATPase subunit S1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Vas1-L1</name>
        <name evidence="8" type="ORF">Hamer_G011596</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vacuolar ATPase subunit S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZ88"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033176">
        <property type="term" value="C:proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030641">
        <property type="term" value="P:regulation of cellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008388">
        <property type="entry name" value="Ac45_acc_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471:SF7">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="7">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7168919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="116" mass="12894" checksum="57028D405E00F005" modified="2022-05-25" version="1">MSYACTQNVTFTAAVNNNTGSSNGLVKLVLSGVQMQPFTVKGKFGGAWDCVGFFTVSIWVSLLATLPMVTILRVGTYMHSDIKTMDRFDDPEGQPLWYQTLIKMKLDTDLRSCCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N225</accession>
    <name>A0A8J5N225_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N225"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28383" checksum="F0473FCEB69CAF07" modified="2022-05-25" version="1" fragment="single">MSSSDHTMKYTSPPPKYEDVVFGAPAGVHGQEGAATAPRLPQNYTHEPLPYVLIPREQLQPVVPGQLTDTFCPAGFECLLTAQEIKVYPSQSRVIKIKNPQKELVFTAKYEYEGDCLTCCCEAGGQMGFTIRTPDKRPLAYMKKFNDSGFFTDIKYMDVSVIPDVPLGRIQCKNNTKFTISNTSGDQLFIIRRKTSFLSNTIYEINRPDGPVFALIEVAGIKHKLKVPPDMQWILWVSGCGTALTYVNKQRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2U3</accession>
    <name>A0A8J5N2U3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2U3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035206356" evidence="1">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="120" mass="13448" checksum="A4B8643A55421DDC" modified="2022-05-25" version="1">MEWHFSLLLLALTSLAASMSQTKDYLPNVAYISSKELGDFLVADKTTLAYWEESLNTANVRTLCGCRTACWSSRWCVAASLDTTSDGVLCRLARLTETNLPQTTKQTNSTYIFFLSKSWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N320</accession>
    <name>A0A8J5N320_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G009621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N320"/>
    <dbReference type="OrthoDB" id="6354475at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="515" mass="56932" checksum="C2AB951AA2C49349" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3E5</accession>
    <name>A0A8J5N3E5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">E4 ubiquitin-protein ligase UFD2-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">UFD2-L7</name>
        <name evidence="2" type="ORF">Hamer_G020345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011048">
        <property type="protein sequence ID" value="KAG7172463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3E5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U-box" evidence="1">
        <location>
            <begin position="387"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="461" mass="52048" checksum="DF4161D825C9F832" modified="2022-05-25" version="1">MDTSSVVPASVGHVNQKHNEDWVRKYEKATALLKVRTLCADHFLFMIQEADKALDAIFSGNLQLLALNKTSLGLFLANCMVQLREGPPAPITHTWETILWAVMYLVKFWRPEFRKCITIFQSKASKLWILRVFNDTEMCPNFRLRLELLFFFGMWPEEDLRSKRVGDQVAIGLVSTTSRLELHHVLPDEMHLSFVYSLTRALHNCFKSGQLVTIASAAIGQVKNLLVGPEVQCLARLVEVASQTVVQLVEWFQEGSLGASLIIEVIEIIFILFRLLLTGSPTKAAYECPGLVQTAAASFFTATSSIVNAATALQVQDAKSYRWLLTDMDDLFGTMAVQEEPQSVMAVMRRNHGQCFSAINQQAADSGYPLYHLPRPCEEQTDNCPEMYIDSVTQQVMEAPVLLKSSKMIVDESTLVHLLLVSPTDPFTRCPLYPGSYTRLPHLRDDIVVWRNRSLFDDITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4F7</accession>
    <name>A0A8J5N4F7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase 1-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GstD1-L4</name>
        <name evidence="3" type="ORF">Hamer_G008613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4F7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="44"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7173090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="139" mass="15836" checksum="6F3FC13D8CD4AB88" modified="2022-05-25" version="1" fragment="single">CGQPLHDAGETSGRPSQPVTRLNSSLSSHSLQCLVPRAPKMAWLSTEFYFYKGSAPCRAVWMTLKVLKVDHEEKIVDLLKAENKRPWFIRLNPQHTVPTVSDQGLVLWERYVPSLPSPPFSHPSWLLYRPVPKCCPLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4L6</accession>
    <name>A0A8J5N4L6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010216">
        <property type="protein sequence ID" value="KAG7172909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4L6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="110" mass="12397" checksum="F16BABC02184AEA6" modified="2022-05-25" version="1">MSILPILCPKVILGVEASKRTRRSTCVTLALHHPPTPTLPTHAQPTYAQPTLPTPVASLLPTLSRPQRLRTPIPREDIHRMIFLLTGKRKPQRKSTIPCWDLYVCTDDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4Q8</accession>
    <name>A0A8J5N4Q8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Enhancer of split mgamma protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Hamer_G018677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009960">
        <property type="protein sequence ID" value="KAG7173392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4Q8"/>
    <dbReference type="OrthoDB" id="6371181at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19741">
        <property type="entry name" value="bHLH-O_ESMB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000009">
        <property type="entry name" value="Transcription factor HES-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="8">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7173392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="236" mass="25801" checksum="AA286DE9A8036C45" modified="2022-05-25" version="1">MVSSVHVEPVSRTDQYKRVMKPMLERKRRARINRCLDELRDLLVAALQAEGETVTRLEKADILELTVRHVRRLNQRRCLTLPPGGHDPRHDALKFQQGFVAAAQQVQSFLIASPSLEPSVSSRLITHLTSCASAISGVPSSNPATSASATPSPGSPSAPPMVIAAPRPAPPRPVMIPAASPPMSPPPLMDLSMKPKLVAPTPIREASNMPQDLSMRRSVPREQDLCPDGKTSWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N684</accession>
    <name>A0A8J5N684_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleolar transcription factor 1-A-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ubtf-a-L1</name>
        <name evidence="6" type="ORF">Hamer_G026496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008311">
        <property type="protein sequence ID" value="KAG7173977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N684"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051762">
        <property type="entry name" value="UBF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46318">
        <property type="entry name" value="UPSTREAM BINDING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46318:SF3">
        <property type="entry name" value="UPSTREAM BINDING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="68"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7173977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="244" mass="28073" checksum="CEC919CA7709FE75" modified="2022-05-25" version="1" fragment="single">QKSQENVSSMSPVKVPADNVLKTSMKRQLKKDSESPSSPSKMENKKQRSNSEKVVSVEDEDLEVECQNWTMEEELELLEKMKALAPKKDTKNCRVRLKNFNWDEVAFGDHSGENCKKRFMEIYSRISSMKTLATIIKEAEEKVSSFASRKKEIRQPISRFSKDFLSKSSVKGPSVFALALEAWKNLPAEQKDMYQAQYQEDLKKLISQPPRKEFKDANLFAMPRKPYHVSTVIVDVAWRTPCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6L0</accession>
    <name>A0A8J5N6L0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Sf1-L2</name>
        <name evidence="14" type="ORF">Hamer_G015731</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BBP/SF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007499">
        <property type="protein sequence ID" value="KAG7174606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6L0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="13">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="229"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="312"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="473"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7174606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="574" mass="60982" checksum="0D54778C1331B1AB" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6P3</accession>
    <name>A0A8J5N6P3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Zinc knuckle-containing protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G015786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007499">
        <property type="protein sequence ID" value="KAG7174651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6P3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7174651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="116" mass="12681" checksum="A0844FD9ADC7D979" modified="2022-05-25" version="1">MGNEIILNIISKYGKVEGMRLNKYTKGPAAGLLNGTRTFKVNLKNNIPSSVTVGGHSLTFLYAGQRKTCYKCGHEGHLAIDCHTEEVDKVNIFNEDDFPAIQLSGESHSSRAGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6W8</accession>
    <name>A0A8J5N6W8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6W8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="117" mass="13166" checksum="C0FCF5AFBBE3C759" modified="2022-05-25" version="1" fragment="single">AERLTACCSKLITRAPRKVTSGARYLRALNPLNHSYCARRNAVNRLKFKDTILSKGPDAMRPDYSIPAPWESPPAVINIHHKLGQERLTANPHELRQMAEKHEGSNTHSSTVYYTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N923</accession>
    <name>A0A8J5N923_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GPI-anchored adhesin-like protein PGA18-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PGA18-L</name>
        <name evidence="4" type="ORF">Hamer_G022452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006308">
        <property type="protein sequence ID" value="KAG7175108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N923"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151:SF2">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035220675" evidence="3">
        <location>
            <begin position="36"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7175108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="851" mass="93594" checksum="831AFD4D798C7737" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N941</accession>
    <name>A0A8J5N941_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formylglycine-generating enzyme-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Sumf1-L</name>
        <name evidence="3" type="ORF">Hamer_G001386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase-modifying factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N941"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120147">
        <property type="term" value="F:formylglycine-generating oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051043">
        <property type="entry name" value="Sulfatase_Mod_Factor_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23150:SF19">
        <property type="entry name" value="FORMYLGLYCINE-GENERATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23150">
        <property type="entry name" value="SULFATASE MODIFYING FACTOR 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="2">
        <location>
            <begin position="95"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="350" mass="39323" checksum="9B021727FF688848" modified="2022-05-25" version="1">MYCADVEKVITMKENKLWFIVYMGLCLFTLCVSSDQCGAPQESESTCGCASTSRKSSGNAFQSDELGDGIEDISKEAPNFKYSQDANAVKDSLQTHQMVEIPGGKFIMGTNNPVFHADGEHPARWVEIRAFFMDIYEVTNAEFERFVKANSYKTEAEKFGDSFVLDGELSEAVKATVENAVAAAPWWVPVKGADWKHPEGPNSDIADRMDHPVVHVSWNDAAKFCKWMGKRLPTEAEWERACRAGKQERLFSWGNKFTPNNVYRANIWQGSFPEQDTGEDGWAGRCPVTAFPPNGYGLHNILGNVWEWTADWWEVSHSPSLQTNPQGPRSGDDKVKKGGSYMCTKEYCYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9I7</accession>
    <name>A0A8J5N9I7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9I7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="104" mass="11511" checksum="4E4A65CB5EFFCB91" modified="2022-05-25" version="1">MKWVEVTGMTGDSVRVKLVEQTILLNTTAEIEGLVIFSGPLVVGSLSTTTGIVNGVNLLDLYYNAWFVDEASQLSRKLVFQARIILKELLPCCCFALTYIKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9P0</accession>
    <name>A0A8J5N9P0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G027911</name>
        <name evidence="2" type="ORF">Hamer_G029822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043522">
        <property type="protein sequence ID" value="KAG7154904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010003955">
        <property type="protein sequence ID" value="KAG7176170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9P0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7176170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="263" mass="30095" checksum="4B4EAEE772BFD335" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIVCGCPHEKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEVIQREEELCQDVYHFFDSSSDEQEATSDDIPPINVNATKLSELVDLSLEILEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA44</accession>
    <name>A0A8J5NA44_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arylsulfatase B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Arsb-L</name>
        <name evidence="9" type="ORF">Hamer_G024301</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004850">
        <property type="protein sequence ID" value="KAG7175674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA44"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF274">
        <property type="entry name" value="ARYLSULFATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="410"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="621"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="466"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="524"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="626"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7175674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="770" mass="85317" checksum="F40359E5F204DF63" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAY9</accession>
    <name>A0A8J5NAY9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003587">
        <property type="protein sequence ID" value="KAG7176216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAY9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="251" mass="28880" checksum="B8824B0138C7ED16" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIEYSETKKQIANAKKREQIREREQKKKMKSEEVIQREEELCQDVYHFFDIPLINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAGGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBF2</accession>
    <name>A0A8J5NBF2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cryptochrome-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Cry1-L2</name>
        <name evidence="16" type="ORF">Hamer_G021928</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003350">
        <property type="protein sequence ID" value="KAG7176479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBF2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF17">
        <property type="entry name" value="CRYPTOCHROME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0274">FAD</keyword>
    <keyword evidence="7 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="15">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="294"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="392"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="14">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="14">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="14">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7176479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="521" mass="60300" checksum="03A0907956A9CEE5" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NES2</accession>
    <name>A0A8J5NES2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001057">
        <property type="protein sequence ID" value="KAG7177924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NES2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="143" mass="15915" checksum="27FE9270DD0D5078" modified="2022-05-25" version="1" fragment="single">TMRHRLLTHCLSGIGLAQNNAIRVIVKAPTWTKIENLHMETGLTSLQTRAERLTACFATKLITRARESDVKNGLLRAVNLNRDVFNKKTRLLCAADAVSRLKLKDTILSKGLDTMSPDFSTPAPWESLPTVFNILQTGTRKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NG52</accession>
    <name>A0A8J5NG52_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RxLR effector protein Htp1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Htp1-L2</name>
        <name evidence="3" type="ORF">Hamer_G003820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NG52"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="262"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7178063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="429" mass="46059" checksum="F2CDF9C1753B9106" modified="2022-05-25" version="1" fragment="single">PTEAPTVAPTVAPTETPTEAPTEAPTVAPTEAPTVAPTVAPTEAPTETPTEAPTEAPTVAPTVAPTEAPTEAPTVAPTNPPTAPPTTAPTTQAPAGPLVYDFQDGMDEWALINMNSASFRRVQFENTRVGAPPEGPWVLQVFQDNVQSGSVVGTGPLMEATDSQISVSVIFWMDGSVNFPAQLKIRRRFSFSDLGETPVLNLDGFGNQDNQMWLLYTGTASAIVGQRFSLLVEASLGGDRNNSVAVNKLVVNGAKAIHSNVTTMNFENGLLGWSLGQMQGGMWELKNQSHIDPALKVPKPPSGDMILVASRQHILSGIMTIESPILSAAAKTSKKLYLRFWVRGSSTYPVSLSIRKKSPDGVYDELPFVNLRRYGNVDSQNWLSLDKTIYVPLNDGEMFYQLVIEVDLGSRLENLVAVDDLSITTLTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T1A8</accession>
    <name>A0A8J5T1A8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011683">
        <property type="protein sequence ID" value="KAG7171750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T1A8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="441" mass="47168" checksum="2C9C54D6BFF1824D" modified="2022-05-25" version="1">MPRRYSWGRYCLVSSPLPPSPTSNTTTLMDPTAQKAPAEAKAEGEQKEEVKKEEEAAAAPVVEEKKEEAVPAPEEKKEEAPAPVVEAPKEDPAPAPAQEVSESNQECLLSNPPTEEEINLAPESQELFESTPLVAEPLTLVESQVCEANLEQSTSHVEDNLEDNYNDAPVLEETCEVLEQHSEFVTLTEKTTSSVIESTVCAISEPVEVSEVVCILCGALTRVTSADGTCDNCHHASEQEQKEEAPAAEETAQKVEEAPAPVEEAAAEPEVKEETVKEEAAPVAESALVEETPVETPAAEPVQEEKKTEEESAPVVEEVPAQESASAQEEVPVQESAPISEKAPAQESTPVEEVAQTTQAAAEPTQQSEVIQTSESTPEQSAEQDTTQQVSEAAAKPATDDIVKKLDSDVEAMLTLAGSAEASVEVKLPKKTEGEGEKVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T4B7</accession>
    <name>A0A8J5T4B7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010428">
        <property type="protein sequence ID" value="KAG7172829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T4B7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="261" mass="29964" checksum="2B2CD2F3D5054650" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLLHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIGRLFVSFKKSSPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERYVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TCY1</accession>
    <name>A0A8J5TCY1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Jerky protein-like 76</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">jrk-L76</name>
        <name evidence="2" type="ORF">Hamer_G014809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TCY1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="176" mass="20496" checksum="170775D1DA1FC7A0" modified="2022-05-25" version="1">MFTSHSNEDTENDFARFRVSKEKQLIHELLAYVKYVTNPDAKKLSSRINEDVLTEWLDVDDNVPTVHHYTDSEFVDMVKSPERNACTGSDEDESSEENEEDVRDRISIDRLIALTTELLAGLEQRSFVSEQEIMNVFLIQDKLIRERPKYMKQQTLPDIFKKIARKQEEATAVSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TFV2</accession>
    <name>A0A8J5TFV2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TFV2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="117" mass="11584" checksum="2B1F98CE70C1E222" modified="2022-05-25" version="1">MGLLTTAVLTAALRLLTVAMGLLTTAVLTAALGLLTVAMGLLTTAVLTAALGLLTVAMGLLTTAVLTAALGLLTVAMELLTTAVPRAALGLLTVAMGLLTTAVLTDALGLLTLPWDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TH64</accession>
    <name>A0A8J5TH64_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CWC15 A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cwc15-a-L</name>
        <name evidence="5" type="ORF">Hamer_G003363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TH64"/>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7174420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="234" mass="26592" checksum="D29C32E506A32856" modified="2022-05-25" version="1">MTTAARPTFEPAKGGMGRGERDLSALSKQYSARDLPSHTRLKYRDHGQSTTEELRSRDFRRELEDRERAVRDKRTSGSSSGGSSSSATRESGISSSSSSSKKPRLDQIAPANLDADDPQDDDDDASDTDDSDDEAVLFGELERIRRERLEEEARKQQERQEQEERIRMENIISGNPLLNLAAVPKSDMKVKRRWDDDVVFKNCAASEPDKSEKAFINDSLRSDFHKRFMEKYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJ58</accession>
    <name>A0A8J5TJ58_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Insulin enhancer protein isl-2b-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">isl2b-L2</name>
        <name evidence="2" type="ORF">Hamer_G021418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003526">
        <property type="protein sequence ID" value="KAG7176444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJ58"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="173" mass="18425" checksum="74902340370E755B" modified="2022-05-25" version="1">MADLCCLRYQQHLALRFCVGDRFYLCDNKILCEYDYEERMVFANMSYSSDSLAHIKRQVSDLQQPPEESGLAQRGNSSTHGTTLPQQPNQQHQLGMNGMSLGGGAGNGPGTSGMLLPTPLGDRSGLGDHHLGGADGVLKAPAAPPQPNSSNQAVADDASSGYGSPDSLTMEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLU5</accession>
    <name>A0A8J5TLU5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FucTC-L3</name>
        <name evidence="15" type="ORF">Hamer_G003754</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLU5"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000004">
        <property type="entry name" value="Glycoprotein 3-alpha-L-fucosyltransferase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="97"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="231"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7178006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="366" mass="42528" checksum="E9AA3377A39D2E67" modified="2022-05-25" version="1" fragment="single">MRKEARVGVLVAGTLILLSSYYKLYGRPLLFQPRNPVNDSWTINDDQDHVEEEFSSRGSTDDLLTWPGDHNLTREKVMPEYLKMETPDSPPDDPPLKKILLWNDMYGKPHYFFGLGREPFVRAGCRVNTCYTTADRLRFPLDQLDAVAWHFRAQDQTLPSQRSTHTRYVFVMQESPMNLFGDLHHYDGVFNWTLTYRLDSDFPSPHGFVTQRSQHSSHDGDGRVDVAELVANKTKLAAWFVSNCHSSSGRESLARTLQNYFPLDIYGKCGVLECPRVHQNQCYTMLQKDYKFYMAFENSLCRDYITEKFFGVLEYYVVPVVWGSGNYTTQAPPHSFIDASRFPSVYDLAQYLLYLHHNDTAYMEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5IZ96</accession>
    <name>A0A8J5IZ96_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G019526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046868">
        <property type="protein sequence ID" value="KAG7153467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5IZ96"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="80" mass="8843" checksum="7834AC614CF294AA" modified="2022-05-25" version="1">MINKGTVGLMNTRVRRVSSLEKTDAVFEVTRPMAKTEKVTSLGWMGLRKPHETVDVIGRSDDRARNLIGSQFKIVGEGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J8Y1</accession>
    <name>A0A8J5J8Y1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heparan sulfate glucosamine 3-O-sulfotransferase 3A1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G018495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043933">
        <property type="protein sequence ID" value="KAG7154767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J8Y1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF7">
        <property type="entry name" value="HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 3B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7154767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="79" mass="9364" checksum="7A0FE4B3FA91DADF" modified="2022-05-25" version="1">MVEFLGLRRVITDKHFFFNATKGFPCLVKREKAGRPHCLGSSKGRSHPPVSQATYNILRDFYRPFNFKFYKMVGHNFHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCK3</accession>
    <name>A0A8J5JCK3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger protein 177-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Znf177-L</name>
        <name evidence="7" type="ORF">Hamer_G010606</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCK3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF161">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7153310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="298" mass="33644" checksum="F0964B7794342BC1" modified="2022-05-25" version="1">MTMSLPQQVSVPSMSVAVTVSVAVPGVHVSVPALNVAGKDDQMNVYFWNKSQENQDAKPQVTGEVYEKRTPFDLHMMQHRGEKPLECDVCGKLFQYRSTLDLHRKTHFKEKVFKCDICGEEFTGKVLLRKHIKHVHTERYFAKRFAGWMGENKNTKSHGDSKPLRCDQCSLLFKDNSKFLLHQKVHRPEKNFKCEVCGMAFAKSYTLEVHQQMHPHVAPLVGTATLTEIPCQGIPTTSTGVMTLTPLYPVTHQAPVVTSETPLVQPPPVVMPGTSKLPTYVKVPMRPIVVKGKRNKQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHK9</accession>
    <name>A0A8J5JHK9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tigger transposable element-derived protein 1-like 155</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TIGD1-L155</name>
        <name evidence="2" type="ORF">Hamer_G022200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040800">
        <property type="protein sequence ID" value="KAG7155725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHK9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="234" mass="26197" checksum="354E108E544FF423" modified="2022-05-25" version="1">MVVVECGCDGGISVVVLVECGCDGGMSVVVECGGGGGGQTPSVRAIVRHTAPHQVWREVDEDVILSPPEYNEQAWKEVTVRCLCAAWRPLWPECVLQRDFEGFEESEEEAVVHEIVALGNSMGLEVDDDDVEELVEEHSKELSTEELLELHKEENETLKRSLTSEESGEEEDKEESRIIPAKDLKDAFFCWSKLSKLAEDYHPDVGSVQKAISVFNDNVMNYFWKIFDQSFPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHW6</accession>
    <name>A0A8J5JHW6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Facilitated trehalose transporter Tret1-like 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Tret1-L30</name>
        <name evidence="6" type="ORF">Hamer_G032151</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047018">
        <property type="protein sequence ID" value="KAG7153429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHW6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7153429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="157" mass="17691" checksum="45860FD525301E00" modified="2022-05-25" version="1">MTLVTFLPAYVGLLVSPESPIWLMKKDRKEEAFQVLSKLRCSDAEKIEELRVVSQNAQPATSCSDIFKTLRKKSNLRAVVSAFILILKEMGGWSVVFGFMIKIFQESGVRLDPSLSSCIATAIFAAVRGVSIFFIFHVPRKPILLVETFSMLWVQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JI96</accession>
    <name>A0A8J5JI96_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein heavy chain 2 axonemal-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Dnah2-L2</name>
        <name evidence="2" type="ORF">Hamer_G022596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039966">
        <property type="protein sequence ID" value="KAG7156130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JI96"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="1">
        <location>
            <begin position="92"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="605" mass="69111" checksum="EC8E342D8EF8C2B6" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JII4</accession>
    <name>A0A8J5JII4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amine sulfotransferase-like 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Amine sulfotransferase-like 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Amine sulfotransferase-like 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Amine sulfotransferase-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Sult3a1-L5</name>
        <name evidence="5" type="synonym">Sult3a1-L1</name>
        <name evidence="3" type="synonym">Sult3a1-L2</name>
        <name evidence="4" type="synonym">Sult3a1-L3</name>
        <name evidence="5" type="ORF">Hamer_G027707</name>
        <name evidence="3" type="ORF">Hamer_G027934</name>
        <name evidence="4" type="ORF">Hamer_G028627</name>
        <name evidence="2" type="ORF">Hamer_G029325</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034207">
        <property type="protein sequence ID" value="KAG7159032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010022221">
        <property type="protein sequence ID" value="KAG7166673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010014420">
        <property type="protein sequence ID" value="KAG7170393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010005106">
        <property type="protein sequence ID" value="KAG7175627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JII4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7170393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7175627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="86" mass="10112" checksum="08C4E7CB36051548" modified="2022-05-25" version="1">MAKLEKLNEFLSTNLSQKQLLYVAKYTEFNEMAGRDSLVGPKTEDNPQYSQEVVRQEGCFFRKGEVGNWKEKLTLDQVHKIDKWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIV8</accession>
    <name>A0A8J5JIV8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Twisted gastrulation-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tsg-L</name>
        <name evidence="2" type="ORF">Hamer_G015925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038275">
        <property type="protein sequence ID" value="KAG7156986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIV8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030510">
        <property type="term" value="P:regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006761">
        <property type="entry name" value="Tsg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057726">
        <property type="entry name" value="Tsg_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12312">
        <property type="entry name" value="TWISTED GASTRULATION PROTEIN HOMOLOG 1-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12312:SF16">
        <property type="entry name" value="TWISTED GASTRULATION PROTEIN HOMOLOG 1-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04668">
        <property type="entry name" value="Tsg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tsg C-terminal" evidence="1">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="131" mass="14499" checksum="91E08E4D6BD1A62A" modified="2022-05-25" version="1">MKSNYATCLPTQDPASQSLMKFISKCLFFMVTVNCTVMYMSQCMSGSKCKATCTTTGATAYRWFFDGCCECVGSPCINYGVNESRCIQCPMVDEDEYDEVLTDQYLAGNSADNFDEVAAQRDIISENDPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKB9</accession>
    <name>A0A8J5JKB9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative MULE transposase domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G024649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037054">
        <property type="protein sequence ID" value="KAG7157646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKB9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF10">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="256"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7157646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="478" mass="53962" checksum="8CCD0291B8AB84D9" modified="2022-05-25" version="1">MKGNVGKFQCLCRGLEGSATLRQPGRLTLPLTSTWIQRWEETGNLADQARRPRSRVTTLQEEESIRQAAEENPFMNPVAIGDELQLNVSNEAVQRRLHEAEIHHRYDRRHIFEEALNETQIRLAKVRNWMKDQATNTRDKPAQIFSHGVSQCDDDVRSLISSADICKRTLRNQRPTPPIPRLLKDLGELPTEFSQTVGPNPEEFLLYDTGPSANNRLLVFGTSDGLRLLACAETLYMDGNFAMAPNIFKQIYVIRVPFGDTAVTSVYALLSNKTRATYEELLQAIVDKCADLNYSITVKTVVTDFEDGVLRAVLAVFGRDVESKGCFYHLTQSTWRKIQELGLGTHYNTNAEFRLFCGMIDALAFLPLDNVDEGMRYLKTVIPQDPPEAEELLMYFDCTYVSGSFRPIQQPVAMSSDALMPLRMRRIPPMFAPHLWKVHDATMNNNAKGGIINSSTSLVTTILQSGVSLNGFNVKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLZ1</accession>
    <name>A0A8J5JLZ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epidermal growth factor receptor kinase substrate 8-like protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EPS8L2-L</name>
        <name evidence="4" type="ORF">Hamer_G024059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038600">
        <property type="protein sequence ID" value="KAG7156838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLZ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039801">
        <property type="entry name" value="EPS8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055093">
        <property type="entry name" value="EPS8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041418">
        <property type="entry name" value="SAM_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287:SF23">
        <property type="entry name" value="AROUSER, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22975">
        <property type="entry name" value="EPS8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18016">
        <property type="entry name" value="SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPS8 spectrin-like" evidence="3">
        <location>
            <begin position="39"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="468"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7156838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="627" mass="72111" checksum="6430BCBED729E2F8" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMV2</accession>
    <name>A0A8J5JMV2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034178">
        <property type="protein sequence ID" value="KAG7159041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMV2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="169" mass="18635" checksum="BFE47C607D570064" modified="2022-05-25" version="1">MSLLVVCLGFCLKKRQQAGAKNRFSLQQNTNETSVKYHSSAGSSSCSIHMGNTSGGLPRSCNPPSRPSLPPPCVPPPLSTSQGKPQLQLPPGVTEGGVQHKDNVKRGVTDENDYCNAFFDLDAGNQLEKEKEEGMKKTREWEKEEGEGNLFNYKSDNSLCKRFNENEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JN07</accession>
    <name>A0A8J5JN07_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G005926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JN07"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="67" mass="7237" checksum="9ED794D58B552689" modified="2022-05-25" version="1">MSKRPATTSLTTAKTKKSRQAITLEQKNKVLEALQHGNGVSCVSDTSKTTPLDSDVDDELVELVSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JP20</accession>
    <name>A0A8J5JP20_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline- and glutamic acid- and leucine-rich protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PELP1-L</name>
        <name evidence="2" type="ORF">Hamer_G013953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JP20"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="724" mass="80550" checksum="A5A0FE0AFACC5F38" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPX7</accession>
    <name>A0A8J5JPX7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps24-L</name>
        <name evidence="7" type="ORF">Hamer_G006287</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPX7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7158909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="138" mass="15813" checksum="1B583E77E13EDFEA" modified="2022-05-25" version="1">MGKESEATATIRTRKFLTNRLLNRKQMVVDVLHPDRATVPKTEIREKLAKMYKTTGDVIFCFGFRTAFGGGKSTGFALVYDTLDYAKKIEPKYRLARQGLIEVKRTARKQRKERKNRMKKARGTAKAKMAAATKKKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ60</accession>
    <name>A0A8J5JQ60_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Alcohol dehydrogenase transcription factor Myb/SANT-like-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G004251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQ60"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="90" mass="10709" checksum="8A5636883EE95ECA" modified="2022-05-25" version="1">MSVPPSATDQGNIHWSREETMVLIELYRQHPCLWNVKVDMCRDRDKRTAALRQITEDMNRSGTTVTTSDVKRKIESLRNQHRRELRKMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQN1</accession>
    <name>A0A8J5JQN1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027477">
        <property type="protein sequence ID" value="KAG7162632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQN1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="110" mass="13109" checksum="687D298C025899E0" modified="2022-05-25" version="1">MNQSSFIDIIIDKSHTRIWIPDNTDDDDTRQPRRHPTTPTTIPDNPDDTRQHRRRYPITPTTPDNTDDNRQHRRRHPTTPTTPDNPDDTRQHRRRYPTTPTIQKEINKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQS9</accession>
    <name>A0A8J5JQS9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pro-resilin-like 82</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G016546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQS9"/>
    <dbReference type="OrthoDB" id="6884310at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035300427" evidence="4">
        <location>
            <begin position="18"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7159163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="144" mass="15662" checksum="1C88A69A3BF7BD0F" modified="2022-05-25" version="1">MTTKVMLLAALVAAALAKPDPQYSPPTPAYNPPAPSYSVPAHPRPSYSAAPAYPDTPPQYNSQYVVRDDYSGNDFGHEESRDGYNTQGTYFVLLPDGRVQRVTYYVDGDSGYVAEVTYEGEAQYPAYQPAPAPSYRPAPAPSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRE5</accession>
    <name>A0A8J5JRE5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G004178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRE5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="78" mass="8554" checksum="5C5DA53E693AB85D" modified="2022-05-25" version="1">MVALRMAGSWLQGSRWAETLVQADIASPGTANSFLKAAHVTRTRRGHQITAATLNILQHKAYGKYSTLKMPKVMVMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWP8</accession>
    <name>A0A8J5JWP8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G023728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030867">
        <property type="protein sequence ID" value="KAG7160734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWP8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7160734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="241" mass="25963" checksum="EA985EA2FC1149C4" modified="2022-05-25" version="1">MVMLVVVFSCCCLVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVAVVIIIGVVQELLSAVQTGEKLALRERLVNTAQANVEYGGLTTRQQQQRLVRHLEHYSGIGCHCVHRYVFLGAKFSYCGPGAAVLWRSPESDLTEVSHTTSQIDPRNTTQDHASSTPHPVPVHIQTVVTSVPPIQASVNTLTEFGNSLYYDPSSRHAQSLSNIADPPPYEVALAGMDEGTLRKLKSENCLPLAPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JX60</accession>
    <name>A0A8J5JX60_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026430">
        <property type="protein sequence ID" value="KAG7163788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JX60"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="102" mass="11863" checksum="190E3E702D021EC7" modified="2022-05-25" version="1" fragment="single">MYTFRIPVTTNSKIIPEACKALYEVLKEDYLKFGHSCTYSESTSPTVNPTIEKPKLKMADSIQEWASVTMMGRDPEFPIHRIRLRTYATGQDVRIRYPAYMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXL7</accession>
    <name>A0A8J5JXL7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable oligoribonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">REXO2-L</name>
        <name evidence="7" type="ORF">Hamer_G004345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXL7"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="37"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7163240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="211" mass="24182" checksum="A16794B9CB520E39" modified="2022-05-25" version="1">MVAGCWRSLLRPHVKLLPRTMSSHTDIPTKIPRLSERLVWVDLEMTGLDVEKEEIMEAAVIITDSELNVVSEGPNIILKVEDKVLDNMNDWCRQHHGKSGLTEGCRKSIISLSAAEDQLLQFVTQHTEKGKAPLAGNSVHADKKFLDKYMPKLMKHLHYRIVDVSTVKELCRRWYPEDFTAAPSKKVSHRALDDIKESIEELKYYKSSIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JY11</accession>
    <name>A0A8J5JY11_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline dehydrogenase</fullName>
            <ecNumber evidence="8">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">prodh2-L</name>
        <name evidence="10" type="ORF">Hamer_G003695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52512"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:58375"/>
            <dbReference type="ChEBI" id="CHEBI:62612"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="8"/>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JY11"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF29">
        <property type="entry name" value="HYDROXYPROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 8" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="9">
        <location>
            <begin position="201"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7164486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="468" mass="50803" checksum="071487E4E7E626B4" modified="2022-05-25" version="1">MLVTSCRLAFSLLRRLPSLRGVGVYGVGVCNLGTVAGGKYQQAHVSVTASADPSTTHPGQDEVKKSAALQLNFGNHKTAFKHKTTRELLRGLVVLHSCAVDTLVNHSHKLLSLGERLLGERLLGYMVAPFYNQFVAGDSGQELGVVSQRLASVGVRLMVAPMLETDVGEGHDARVSTAYQSLSMAERVEAVRVVAALLVEVGSDGHTTTSSHLLHPLQLKESDALELIDSLPRLYKLGAQCVLQDVVLAVDAEYTYTNPAINLLSLAMMKVFNNPTPIIWNTYQGYLKAGRENLEHDLGVVRALGGNVGFGAKLVRGAYLERERSLAQEKGYPDPVNNTYEDTAAVYTSMVEVMLQEVAAEAESRAVVVATHNEASVKHAAGRLEQLRLDPQAGNVVFGQVYGMAENISVPLAASGFLVFKSVPSGSMSEVMPYLSRRANENRAVLRGARRERQLLTRELLSRLPFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYB5</accession>
    <name>A0A8J5JYB5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G031624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026281">
        <property type="protein sequence ID" value="KAG7163799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYB5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7163799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="222" mass="25298" checksum="6F38DE56A9EAE257" modified="2022-05-25" version="1" fragment="single">PLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPRTKAEGHGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDLGDCSFHSRKVPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYP3</accession>
    <name>A0A8J5JYP3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026025">
        <property type="protein sequence ID" value="KAG7164039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYP3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="228" mass="25862" checksum="1D6ADBA36FF0BF73" modified="2022-05-25" version="1" fragment="single">PLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGLIDYSETKKQIANAKKRTNPREGTKEENEEKVPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGYVYSHERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZX0</accession>
    <name>A0A8J5JZX0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell division cycle 40 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PRP17 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Cdc40-L</name>
        <name evidence="13" type="ORF">Hamer_G017321</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZX0"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="275"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="405"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076678"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7164913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="570" mass="65673" checksum="B515A92ADA58ACB2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K073</accession>
    <name>A0A8J5K073_HOMAM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G004678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Malacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7164954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K073"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="79" mass="8780" checksum="BB3B82BCFF0FDFB8" modified="2022-05-25" version="1">MTFRKLPNVDHRHYKLGSLKPAGNTRTICTTWAPPGGITTWAPPGGITTWAPPGDITTWDRLPPVHHLEAFHPAHHLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1N2</accession>
    <name>A0A8J5K1N2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Obstructor-E-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">obst-E-L7</name>
        <name evidence="9" type="ORF">Hamer_G024752</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019942">
        <property type="protein sequence ID" value="KAG7168617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1N2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF107">
        <property type="entry name" value="LD20793P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        </location>
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            <end position="105"/>
        </location>
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        </location>
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            <end position="243"/>
        </location>
    </feature>
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            <end position="462"/>
        </location>
    </feature>
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        <location>
            <begin position="474"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
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            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7168617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="532" mass="58700" checksum="72330082F808D84A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1N9</accession>
    <name>A0A8J5K1N9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nicotinamide riboside kinase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Nmrk1-L</name>
        <name evidence="1" type="ORF">Hamer_G013654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022272">
        <property type="protein sequence ID" value="KAG7166631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1N9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="252" mass="28571" checksum="DA9E73AAEA92B574" modified="2022-05-25" version="1">MREPMASRTVPSSQNQPVKSGGCKWLVIGLSGVTGGGKTTLATQLIASLPTTTVYLCQDEYILPDHHQAHLKVPEPLQGPNKNSLCSVDMTKMIADIKHILLTDSADINLVDFIGLEDRGKVIGQGLNTPRPPFRGHKQRSHWPSLLLLDGFLLFNHPEVPLMCDLLYFITLTKRQCLERRKMKVFTSSSLSTQQYFELCAWPQYERHFTDMCESVKGIHFIDGESPRHAVYKRVFTDIMNMLDRDDCQKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1P1</accession>
    <name>A0A8J5K1P1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DDE superfamily endonuclease domain-containing protein 68</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1P1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="136" mass="15226" checksum="AF8108451986070F" modified="2022-05-25" version="1">MKAACVAFAQYMYEDGIHKQRVYVDEAGYNLYTYRTYGRVPRGQFVNRIVVGQLGSNVTLIVAISNLAGLFHYEIHITSVTKEVFKNFMTSLDSVLGPEAAVILMDNAPCPAGIEQEFEDRVIKNLPPHSPFLNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1Q6</accession>
    <name>A0A8J5K1Q6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neuroligin-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Nlgn3-L</name>
        <name evidence="6" type="ORF">Hamer_G020843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019607">
        <property type="protein sequence ID" value="KAG7168677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1Q6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="243"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7168677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="606" mass="66424" checksum="71DA80DAB613538F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3L8</accession>
    <name>A0A8J5K3L8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Ecdysteroid kinase-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3L8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="134"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="417" mass="47929" checksum="C1FC730FF5354AFA" modified="2022-05-25" version="1">MKGQGTHATSKSQIKEEYVKTALKVDKGSDAQLISWVTEDFTQKGEHFACIVTSIKVKYRQGGIENNITYVVKLNPQRNMKELREYVRLNFIKEVGYYQDLVPLFNAELQNFGIEPLRMPTCLFVHMTEGEEVMILGDLRPEGFKVLDRKKGMEKEHTIMVMKEMSKIHAASTLVEKKAEEALELKHKYLLVDMSSMKQFDKFFTGSMRSAADLAEKVGGYERHAAWFRNFAPKCGDAFKEQLKRSPPFDVVCHGDCWTTNVLFRYDESGAPVDLRLLDFQVCRKASLATDLNFFMYTSLTGDQRKENLHVFLKAYHDSFRQVMEGAGFPMPFSTEELLQEYHKRNLFGFIMGLIAVPILLTMSKEALDLNSVKDENIENFVSDQKNKNLKQLDSNPLLRPRLLSLFDDMVEFGIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3N0</accession>
    <name>A0A8J5K3N0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein 64-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Zfp64-L2</name>
        <name evidence="11" type="ORF">Hamer_G011931</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7166003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3N0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000130">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7166003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="103" mass="11775" checksum="8445468C3D70FFFA" modified="2022-05-25" version="1">MVGCSSSNTTFAKLNQCLYCLYSTPIITNLKNHMLTHTDEKPFACTWCPYRCKQKGNLKRHIVTNHSAEMLMLSKTGNEYGARDLSDPSAIILPRNQYMDELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3U2</accession>
    <name>A0A8J5K3U2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pro-resilin-like 161</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G026958</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022469">
        <property type="protein sequence ID" value="KAG7166570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3U2"/>
    <dbReference type="OrthoDB" id="6342716at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035326493" evidence="4">
        <location>
            <begin position="16"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7166570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="131" mass="14021" checksum="EC3D59E9B2BB2F9B" modified="2022-05-25" version="1">MKVVLALTLVAAAMAAPSRRGYGFSPAPVPAPAPSYRPAPSYRPTYGPAQYSFDWAVNDAPSGNDFGHEETRNGDNTQGSYYVQLPDGRLQRVTYTVNGGSGYVAEVTYQGEAQFPTYSAGPSYRPTPAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K487</accession>
    <name>A0A8J5K487_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K487"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="134" mass="14683" checksum="B7B15D5FCE7B4D04" modified="2022-05-25" version="1" fragment="single">CRMGIFLSCCGGGGSGDSSNYNNIHEPPEPADPVRSLERQIRSKAEAIKGWCEGPRGSKVQQKRKEELELRQEAEGKPDGGLRVCSEILASELDSRILIVCTSSEDLPGMSDHFIGNLSYTKTPFIIMNFTGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5D8</accession>
    <name>A0A8J5K5D8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G022976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014835">
        <property type="protein sequence ID" value="KAG7170220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5D8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035291688" evidence="2">
        <location>
            <begin position="20"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="237" mass="26041" checksum="C60325063C1D5FDE" modified="2022-05-25" version="1">MRFLLVVLLVAALGLSVLAAPAELETHHREARGVDLVSKFIGGLKLGLLAGTNARPLAEAGLLAESFAQLGDMRQSLAAIKVRRGRKSKLHKNTNHYTYTVTFDVIASAHPTAHTITHIIYTTAQIAHATAHITHTTAHIAHTTAHAIYTTTHTTHLTASPTPPPATAHAIYTTTHTTTHITHTTRLDRLFNPAMVLFLFLAINFLCLWREQWNKALCWRGQWNKALTSDHLPAVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5S7</accession>
    <name>A0A8J5K5S7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dipeptidyl peptidase 1</fullName>
            <ecNumber evidence="5">3.4.14.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cathepsin C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Cathepsin J</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Dipeptidyl peptidase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Dipeptidyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Ctsc-L7</name>
        <name evidence="19" type="ORF">Hamer_G023430</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.</text>
            <dbReference type="EC" id="3.4.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.1" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010012711">
        <property type="protein sequence ID" value="KAG7171212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5S7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.80:FF:000003">
        <property type="entry name" value="Cathepsin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.80">
        <property type="entry name" value="Cathepsin C, exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014882">
        <property type="entry name" value="CathepsinC_exc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036496">
        <property type="entry name" value="CathepsinC_exc_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08773">
        <property type="entry name" value="CathepsinC_exc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75001">
        <property type="entry name" value="Dipeptidyl peptidase I (cathepsin C), exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0868">Chloride</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035304978" description="Dipeptidyl peptidase 1" evidence="17">
        <location>
            <begin position="19"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="18">
        <location>
            <begin position="220"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG7171212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="409" mass="45816" checksum="FF4BA1EAAC845AC2" modified="2022-05-25" version="1">MLMLVFIVLAGATALVTADTPANCLYEDIRGTWTFSETERTGDHTINCDELGPIVHAKNFTLSFPNTATDELGNEGTWTLIYNQGFEVNINERSYFAFSYYEGDLNAVVSYCDRTFNGWSRDKTIRNWSCYTAQKTTPVNPRVDARPAQRELDRPFRNDQSFIDKINAAQSSWTAKAYPEFTKYTVKEMQRRAGGPKPAISSRPRPAPATAEQKAQTALLPEHFDWRDVEGENYVSPVRDQGGCGSCYAFASMANLEAQVRIATRNQRQDVFSPQDTSCATDNSCSRTYVSDYQHVGGYYGACNEEVMLEALVTTGPISVSFEVYSDFSSYNGGIYHHTGLESDFNPFELTNHVVLIVGYGVEEDTGEKFWIVKNSWGGSWGEDGFFRIRRGTDECAIESMAVQVTIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5U2</accession>
    <name>A0A8J5K5U2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020877">
        <property type="protein sequence ID" value="KAG7168074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5U2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="458" mass="50132" checksum="49D8FE19382E3D09" modified="2022-05-25" version="1">MDYDNICFIIITIIITIIIITIIIIIIITITIIIIIILKSDEREKSQCHLRHLGATYVTWVPPTSPGCHLRHLGATYVTWVPPTSPGCHIRPWVPLRHRGATYVTWVPPTSPGCHLRHLVPPTSPGCHLRHLCHLRHLGATYVTWVPPTSPVPPTSPGCHLRHLGATYVTWVPPTSPGCHHVTWVPPPHLGATYVTWVPPTSPRCYLRHLGATYVTWVPPRHLGAISPVPRHLVPLRHLVLVTWVPPTSPGCHLRHLGATCVTWVPPTSPGCQLTSPGCHLRHLGATYVTWVPPTSPGCHLTSPGATYVTWVPPTSPGCHLRHLGATYVTWATTSPGSRHLLTGCHLRHLGATSSPGCHLRHLGATYVTWVPLRHLGATSSPGATSHLVPRHLGATYVTWVPPRTWATYSPVGAPTSPGCHLRHLGATYVTWVPPTSPGCHLRHLGATYVTWVPGKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6R1</accession>
    <name>A0A8J5K6R1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G030775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013928">
        <property type="protein sequence ID" value="KAG7170551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6R1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7170551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="120" mass="13733" checksum="C6AE5D6F7669D513" modified="2022-05-25" version="1">MEKEDIVAARNKYLRYIQKNRESSNPRPEVYLDETWINQNQCVERCWTVNDGSAGPKLKSGRGARFIVAHAGGRQGFIPGALLMFRSKNGAKGDYHDSMDHERFKAWFKEQLLQNIQGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7P6</accession>
    <name>A0A8J5K7P6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018457">
        <property type="protein sequence ID" value="KAG7169106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7P6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="400" mass="44567" checksum="AA885E8A3055D302" modified="2022-05-25" version="1">MVVEQTHRAMTSSPVMVCLIGETRSPSFTSHEPFPHSCTSQRVLSSPLHITVGPSLTPTHHSESVPYPTQHCISFPHSYKTLQILLSLLRSHTKSFPHSLHNIPSPSSLPTQHTKSFLTPTQHTKSFPPSYKSIPHSYHNIPSPSLTHHHTASPSYTAIPSPSSLYTVLQDNPSLLHNIPSPSLTPTQHTKSIPHSPTQHTNPSHSTQHTIISSYQHTNPSLNPTKHTSPSLTPRQHTKSFPHSHTPCQVLPSLYNIPSHSLTYNIPIPFLTLHNIPSHSSLLHNIPSPSLFTTPYQSFPHSTQHTVIPHSTQLTKSFPHPTQHTKSIPHFYTTYQVHPSLLHNIPSHSSLYNLPSPFSLLHNIPSPSPPPYTTLRVHPHSLHNTTSPFPHAYTKLQVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K826</accession>
    <name>A0A8J5K826_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prostasin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Prss8-L</name>
        <name evidence="5" type="ORF">Hamer_G023150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020272">
        <property type="protein sequence ID" value="KAG7168268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K826"/>
    <dbReference type="OrthoDB" id="10037376at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035174489" evidence="3">
        <location>
            <begin position="18"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="51"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="333"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7168268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="539" mass="58276" checksum="C174C2C7107153AE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8I4</accession>
    <name>A0A8J5K8I4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-related protein Rab-27A-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Rab27a-L2</name>
        <name evidence="6" type="ORF">Hamer_G021999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017059">
        <property type="protein sequence ID" value="KAG7169376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8I4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7169376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="138" mass="15855" checksum="E0634CEFA50DAA14" modified="2022-05-25" version="1">MESTTSSGKDYDYLIKFLALGDSGVGKTSFLYQYTENVFQQQFISTVGIDFREKRLIYRGDGTGRPQGVHLQLWDTAGQEKFRSLTTAFYRDAMGFLLLFDLTNEQSFLDIRSWLEQLKVGLEYNFIAGYSSELSIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KDR2</accession>
    <name>A0A8J5KDR2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholysine phosphohistidine inorganic pyrophosphate phosphatase-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Lhpp-L2</name>
        <name evidence="2" type="ORF">Hamer_G028856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013941">
        <property type="protein sequence ID" value="KAG7170549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KDR2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF44">
        <property type="entry name" value="PHOSPHOLYSINE PHOSPHOHISTIDINE INORGANIC PYROPHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="235" mass="26392" checksum="5D0B24EAEE9E628D" modified="2022-05-25" version="1" fragment="single">WKEVTVRCLCAAWRPLWPECVLQRDFEGFEELEEEAVVHEIVSLGNSMGLEVDDDDVEELVEEHSKELSTEELLELHKEENETLKRSLTSEESGEEDKEESRIIPAKDLKDAFFCWSKLSKLAEDYHPDVVVIMSGWLSEPIKGVLLDITGVLYESGEGFGTVIPGSVEAVERLREAGIPVRFVTNETCASRAAVVVKLRHHNFSLSEADVFSPVPAVISVLRERGLTPHTLVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KHQ3</accession>
    <name>A0A8J5KHQ3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KHQ3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="135" mass="14686" checksum="5198F4E326DC0B3A" modified="2022-05-25" version="1">MDVGMVVSAAVCSTDTHSNNSSNAATVDRIFAVAWYMVVTCCIKTLLGFLSPSAAPVTLRQSPVNGRSDNTHSGTIEASCPSCAERRWSPWTLFGWFMPLIFSIENSELAGCNTCYVIVLAIDIVMILIIILFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ML69</accession>
    <name>A0A8J5ML69_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ETSous factor-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Ehf-L7</name>
        <name evidence="5" type="ORF">Hamer_G024546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041629">
        <property type="protein sequence ID" value="KAG7155451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ML69"/>
    <dbReference type="OrthoDB" id="5975550at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF190">
        <property type="entry name" value="ETS-DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="4">
        <location>
            <begin position="158"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7155451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="254" mass="28908" checksum="3A8B72DADF4671C4" modified="2022-05-25" version="1">MLYSSPKPTACGKRTWWEIENGLSPEASPTRITRRGRMCNDHGAQQEDGYQRVISNFLETLHLPDVEAPYEPVIESINPDDDVRPLNISHSLPTPCGKVTPFIVAPLPVVQINTMASDQITGSLSQEVAGPQPQQPPAKRRPGRPPKPKQQLQPKKIPKIWEFVHDMLQDPATCPSVVRWEDEKNGIFRFIDPKKAASLWGDLKENPKMSYEKMSRALRYHYTSEALDVVRNRRLVYKFGKKAHKNNKKLTPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLF9</accession>
    <name>A0A8J5MLF9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027995</name>
        <name evidence="5" type="ORF">Hamer_G029820</name>
        <name evidence="6" type="ORF">Hamer_G030627</name>
        <name evidence="3" type="ORF">Hamer_G031045</name>
        <name evidence="2" type="ORF">Hamer_G031056</name>
        <name evidence="4" type="ORF">Hamer_G031120</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040658">
        <property type="protein sequence ID" value="KAG7155764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010015250">
        <property type="protein sequence ID" value="KAG7169838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010010572">
        <property type="protein sequence ID" value="KAG7172569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010009872">
        <property type="protein sequence ID" value="KAG7173446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010004778">
        <property type="protein sequence ID" value="KAG7175694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010002298">
        <property type="protein sequence ID" value="KAG7177466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLF9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7173446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7175694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7177466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="70" mass="7929" checksum="ED666DA4C0A6057D" modified="2022-05-25" version="1" fragment="single">PSTKTREEGKGSVDRFFQVTEYLKLPQRGMVVFSRAEGLEGRTLTDGQNNREWTTVSHAWSCEGSEHPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLK9</accession>
    <name>A0A8J5MLK9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glutamate-gated chloride channel-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GluCa-L4</name>
        <name evidence="10" type="ORF">Hamer_G012163</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7156008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLK9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="682"/>
            <end position="704"/>
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        <location>
            <begin position="711"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="748"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="202"/>
            <end position="313"/>
        </location>
    </feature>
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        <location>
            <begin position="858"/>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
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        <location>
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    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
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            <position position="1"/>
        </location>
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    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="961"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7156008.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="961" mass="109128" checksum="5867FAAE57503B1A" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLR9</accession>
    <name>A0A8J5MLR9_HOMAM</name>
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        <submittedName>
            <fullName evidence="5">Pro-resilin-like 151</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">Hamer_G023560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040175">
        <property type="protein sequence ID" value="KAG7156066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
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        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="19"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7156066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="402" mass="43530" checksum="5DFDFBBA7462467D" modified="2022-05-25" version="1">MKTVAVVVVVSVVVAAWATPQFTNAPTQYSFEWGVSDENSGNFYGHREQRDGAGTQGSYYAKLPNGLSMKVQYTVDKSGFRPSTVTTEGQTQRRSVKVQRPTAPRSHPLSLTKDPITARQAISSVPNPATLPDRRPQPPVRPIVVPGSVTGPFTSQHQPSSSPGVVSSYATVPPLTVGQGVVPTGSRPPAKSLSNTKTGSFSPSGSKILRDADNINRVPSSLIQPTIHSILKPKLVPSLSFPTISVSLHKPKGFIPSPHPPKDHTVHKLSAHLPERGVSTSLSTSVPPATLSPRREVRPQLNSLDLGKFSKHEEILLPESFTASQPRTLQPSQIPTASHFTHEKGELRPIRVSKESKSGFKWIDSPFHRPREVNIITAAPPLPNYDFLLLAEAMKVSDGRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPN3</accession>
    <name>A0A8J5MPN3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pro-resilin-like 67</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G016521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPN3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035204807" evidence="3">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7159141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="124" mass="13524" checksum="19DE7CA92B353C8F" modified="2022-05-25" version="1">MSVSTNYHLLHTQVLVLAVLVASVIALPSSHPSYGAPSVPAQYDFTYAVKDSYSGNDFGHQENRNGYNTQGVYFVQLPDGRVQRVTYTVNGDEGFVAQVGYQGEAQYPAYHPSPSYNPGPSYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQ89</accession>
    <name>A0A8J5MQ89_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032177">
        <property type="protein sequence ID" value="KAG7159788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQ89"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035299153" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10861" checksum="DCB20A7BABF373B5" modified="2022-05-25" version="1" fragment="single">MFSSGSVVAVVVAVVVAVVVGDSGYFPSPASARCYPEINYVTKYQTEYQQVPVYTSIYKQQVVPTTLTEPSTKLTTRPSTRPNSSKYETEIVFRTQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRH6</accession>
    <name>A0A8J5MRH6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase type-2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">scu-L2</name>
        <name evidence="4" type="ORF">Hamer_G016279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRH6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008209">
        <property type="term" value="P:androgen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008210">
        <property type="term" value="P:estrogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05371">
        <property type="entry name" value="HSD10-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7161225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="299" mass="31732" checksum="61E490C4775381D4" modified="2022-05-25" version="1">MLKGLVSVVTGGASGLGRATVERIVREGGRAVICDLPTSQGAKVAEEIGDSVIFVPTDVSSAGDVEAALALCKDKFGGLHVAVNCAGIGLAVKTYNHNKKVSHSLDDFMRVQKVDVGDFTLLMLMITMITTTTTTTTTTTILIIIIIIIIIRRQFPQVNLGGAFNMIRLSAALIAENEPNVDGERGVIINTASIAAFDGRIGQAAYAASKGAIIGMTLPIARDLSPLGIRVCTIAPGLFRTPLMLALPQKVLSFLEKMTPFPQRLGDPDEYAKMVQEIITNPMMNGSTIRLDGAIRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU30</accession>
    <name>A0A8J5MU30_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tigger transposable element-derived protein 1-like 169</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TIGD1-L169</name>
        <name evidence="2" type="ORF">Hamer_G002136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU30"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="457" mass="50495" checksum="FDE178A65764FB35" modified="2022-05-25" version="1">MTWKEVTVRCLCAAWRPLWPECVLQRDFEGFEESEEEAVVHEIVALGNSMGLEVDDDDVEELVEKHSKELSTEELLELHKEENETLKRSLTSEESGEEEDKEESRIIPAKDLKDAFFCWSKLSKLAEDYHPDVGSVQKAISKGLSDMQVNYIEEFLGSHMEGLTKDDLQGKPVATDVTTVSIIDPQLCTRDYTTATTNNSPPAKLPLRHLPHQTLTNLKRYKKRVGLCAPLVTTTSPFTSATSTIIINVVKDPPLAASAALPGSLTASASTPPPGSPATPATPAPPGVPSTSTMTVTAFWKNYNICQAVNFFVKAWGNTTKATVRHAWSALLPQLKSVETKRQQPAELMNQVLETVRSIPAPGFQEVTREDLEELMQEVNTNDVEDLLEDEEGGASGDAVSDAGETEQRKVMTQKLSLLLGVCTSLQEMIQDIESESGEREQMIGFVESISRKYQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU83</accession>
    <name>A0A8J5MU83_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase p58-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU83"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase p58-like C-terminal" evidence="1">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="122" mass="14298" checksum="0A2AD8AFE17BD533" modified="2022-05-25" version="1">MSGPDEELPEETTSYVKSLQERVTEVHHQVRGTLEFSGEVMKLNYYVKAGQVCYKDGDKIWLYNPLQKKGHSPQLHIPWEGPYTVVERLSDVTYRIIGRRKAQPKVVHVNRLWQYHEPGQYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUJ4</accession>
    <name>A0A8J5MUJ4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tramtrack-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ttk-L4</name>
        <name evidence="4" type="ORF">Hamer_G019122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026149">
        <property type="protein sequence ID" value="KAG7163852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUJ4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF109">
        <property type="entry name" value="FI07618P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="381"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="525"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7163852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="720" mass="80183" checksum="F8AE196CDFD448B7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MV90</accession>
    <name>A0A8J5MV90_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Smpd3-L</name>
        <name evidence="5" type="ORF">Hamer_G005002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MV90"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF1">
        <property type="entry name" value="SPHINGOMYELINASE DDB_G0288017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="4">
        <location>
            <begin position="165"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7164617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="456" mass="51510" checksum="CB30893EB5F5986C" modified="2022-05-25" version="1">MPPPRPSRYDSWVLEVIDAVTCILMYPFLQITSLGASHCVLITADNASLPYHILRCLVMGPISLVLAFVFAPLVFIGYVLWVLLNKFADVQPFYYVSPSCQQPSVYKEGSECASKFTFCSANVLLSSKIVECINNVRCGSGRVHKIARGLLQQDPSLNDSRNLHPPTKRENIVQSKLPEVDVIILQEVLERSRAKQLIKYFESKYPYCIYDVSVHSMTTNLCAVGSGLFLASRYPVLEATFHPFTYKTHYGIFLDLGILTENSEAVRGVGYVTNIHTQLEEVRQRVKSYISNTHNPQNEVVVFSVIGGDFNCDNMSPGDAGTQDLPLWDEYKDPCRECAGTDKPWTVGTEHRQRRLHDPVLEKPEIFRDILLDDVQRRIFMLDANIKEQTLELMWVNPKPGPSGMVEAIKEGGRRRIDHLILRNGDMVKPTAFWFSTVIGGLSDHMPVALTVERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVD9</accession>
    <name>A0A8J5MVD9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hAT family C-terminal dimerization region-containing protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVD9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF35">
        <property type="entry name" value="AC-LIKE TRANSPOSASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="149"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="252" mass="28521" checksum="232F448E18CBD13E" modified="2022-05-25" version="1">MQLDVAMGLLKNTKASLVSYCENGFVSAQASAKNMCKEMNMEAVLKKKKLGMTKIHFGYEAPDEPISDASKRLEVSFVNTVVDSAITSLNERFQSLGEVRDKFRVLFHFKELSFDSLTRQYEELSDSLSYGGELDIDGKELAFDMRNLPKLPSDSTTALELLKYIHEKEIKELYPNMWTAIRVAVTFHVTLAAAERNFSELKLIKTYLRSMIAQDRLTGLAVISINNAVGRQMSYGDIKDNFASKKTKKQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW18</accession>
    <name>A0A8J5MW18_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G004939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW18"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="336" mass="38028" checksum="DD485081DFDC1C7B" modified="2022-05-25" version="1">MRSTTTTMEEIIQEANKAVLEATPPAGQEKSAAALHFPGVRFADENITTKPQQETQVVVESLRNNTMEDVRPPEKEEVEVVEVDWLGVPLASSTLPDYTSMYRHHYPDYTRGDILAHQREYQPVTSVNRRTEGRELHEQFEGVGWVSRDTVPTGQVGGYVKKGGQVGRALLHPQGDRWTTPPPVVDRLRRTDPMEYLNLCEPLNKLPVERLVYQWVVQDQAALDERATVGRSCRTSGFTANSSPHLPPPEDRNFFSVYAHSYNVQVPCDDVEGLHPSLQPPAAALEYPGYGGTHTMDDTPSAFLRLTPHQLRTKPDLLQRSRSHRLRQEHKEFTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW20</accession>
    <name>A0A8J5MW20_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022487">
        <property type="protein sequence ID" value="KAG7166565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW20"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="109" mass="11746" checksum="27E0AE23EF1A9091" modified="2022-05-25" version="1">MDALERQKAALAFSTMAGLAQFGSSLKALADSSNSLHPDSASGVYEALSTLASGLASASVFNLRLQLDKSVGAQLNLRWQSFRHRDEEVRQSLLRLAPFAPSLIPEETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXX8</accession>
    <name>A0A8J5MXX8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027402</name>
        <name evidence="5" type="ORF">Hamer_G027753</name>
        <name evidence="3" type="ORF">Hamer_G027924</name>
        <name evidence="4" type="ORF">Hamer_G028687</name>
        <name evidence="6" type="ORF">Hamer_G031251</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035205">
        <property type="protein sequence ID" value="KAG7158410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010028256">
        <property type="protein sequence ID" value="KAG7162015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010024569">
        <property type="protein sequence ID" value="KAG7165200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010021365">
        <property type="protein sequence ID" value="KAG7167676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010001363">
        <property type="protein sequence ID" value="KAG7177883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXX8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7162015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7165200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7167676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7177883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="147" mass="16609" checksum="1E1230B50B3EEF6D" modified="2022-05-25" version="1">MTASGLGPNPTPPETRSSEASVSVLADRRNIIPIKTLHCMASLPYNESPNLLYQTFTCLKRLAQTHPPRQKRGLQSTTLVTAEEPRARSVGVKPERSFNRGLWFRRKMPFLSFCNVKARPPNFSHGNRRTRPPADALWVPRHPNKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYM8</accession>
    <name>A0A8J5MYM8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myb-related protein A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MybA-L</name>
        <name evidence="7" type="ORF">Hamer_G018404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7167974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYM8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000010">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015395">
        <property type="entry name" value="C-myb_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF25">
        <property type="entry name" value="MYB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09316">
        <property type="entry name" value="Cmyb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="48"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="489"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="588"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7167974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="815" mass="88832" checksum="8D5BAD4A2E5433D9" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZS6</accession>
    <name>A0A8J5MZS6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018083">
        <property type="protein sequence ID" value="KAG7169177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZS6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="179" mass="20675" checksum="55E9A8CA9D97C113" modified="2022-05-25" version="1" fragment="single">LFQVKMVLANRGQLRSESNKPQLTNLVTVAAAAVLRLLTAAARRRTWKKDKMQLIIIVQTHIPSHLRQRLQERVLYDWRLYDTVSLRLLELVFSSTTSSLRLHHVRAFFRDDLTRLLVRLSGLQELMIQDPTWSLSTHQLTLVADALTKMTCLRVLTLQYCTHNKLLAALADTCTSLQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N008</accession>
    <name>A0A8J5N008_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Nephrin-like 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Nphs1-L33</name>
        <name evidence="3" type="ORF">Hamer_G021980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016826">
        <property type="protein sequence ID" value="KAG7169417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N008"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7169417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="573" mass="63562" checksum="9105D88B1235FC01" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0I8</accession>
    <name>A0A8J5N0I8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G025126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013425">
        <property type="protein sequence ID" value="KAG7170825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0I8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7170825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="143" mass="14676" checksum="F592660D4D4BAD2C" modified="2022-05-25" version="1">MRRVVVTRGHPAGAGGVAPTPGWWGLVTRPPPRYFTPLPHTTQLHMSVWCGTRATLGLCAYTGHHLPAGGVAPPGYTHTQTLGASPETRDGGNTIATLRRGGSTNSVCLKPLTDTSLATVAPPGLTTACCTSEGPAGAVRPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0L3</accession>
    <name>A0A8J5N0L3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G012470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0L3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7170900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="368" mass="41860" checksum="C622B75181186CE4" modified="2022-05-25" version="1" fragment="single">ASGLGQAAETDQNHFLQDEPLLLHWDGKLLPDVQNTTASRIAIVVTFNGQEKLLGVPKKERETGEAQAEACLEAIKSWNVEKLVKGLVFDTTASNTGLHRGACVRIEDELEQELVWIACRHHVLEIMLSDVFSLICGSTGSPETILFKRFKKQWRSISLNDFIPAPESIFWHEAPMAVRAPFNDLQLMKVLKEYPHEKVAHAAQAAISRHLWYLSEHLIGLSLFDDRIDTETKKNMVQNFQCPKKQDFSRRIVLSDETPISNVASFVTERTLDIFDVLTLDGKERAQLFLSKDPKTWKDDEVFITMRDRAINMKVVNDSAERAIALIERYNESITQNEDQKQYLLQVVAAHRKKLPTASKAAMMKGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0M1</accession>
    <name>A0A8J5N0M1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial import receptor subunit TOM40 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Tom40-L</name>
        <name evidence="12" type="ORF">Hamer_G012552</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0M1"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000005">
        <property type="entry name" value="mitochondrial import receptor subunit TOM40 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7170978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="327" mass="35226" checksum="C51001B105E9FBE4" modified="2022-05-25" version="1">MGNIQAAGPGVLAPPPPQPAPLTVTPTPEEKKTEVVEGGTENPGTMEDLHKKCKDVFPVMFEGGKFMLNKGLSNHFQVSHTINFSTVQPPGYRFGATFVGTQQVSPSEAYPVMLGDVDPSGNLNANIIHQLLPNLRGKFVAQIQQSKWQATQVTMDWRGADYTASLTLGNIDIINGSGVAVTHYLQQVTKKLALGTELAYQYGSQVPGGHIAVHSIAGRYTGDSFTASGTLGGAGIHLCYYQKATEQLQFGVELETSLRMQESVASMAYQLEIPKANTVFRGTLDSNWTVGAVMEKKLMPLPFTLALSAMLNHPKNQFKIGCGFIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N110</accession>
    <name>A0A8J5N110_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-dependent helicase brm-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">brm-L</name>
        <name evidence="12" type="ORF">Hamer_G013498</name>
    </gene>
    <organism evidence="12 13">
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7172295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1015" mass="112722" checksum="01CC2EE122FB9F24" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3P4</accession>
    <name>A0A8J5N3P4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Down syndrome cell adhesion molecule-like protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Dscam1-L2</name>
        <name evidence="3" type="ORF">Hamer_G026058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010997">
        <property type="protein sequence ID" value="KAG7172474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3P4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF104">
        <property type="entry name" value="BASIGIN, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="167"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="254"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="495"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="585" mass="62533" checksum="C6F5BB0FDCA3F4B5" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N468</accession>
    <name>A0A8J5N468_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
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            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N468"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="107" mass="11656" checksum="DE35472E5583F81F" modified="2022-05-25" version="1">MELSSPQGEHHHGVIITTGGALPQREHYHKGALTWREHHHGVIITTGSITTEGESTWREHQTSPQGEHHHGGEHHQGASPQGEHHHGEASPHGSITTGEHHHRGASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4F3</accession>
    <name>A0A8J5N4F3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neurotactin-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Nrt-L1</name>
        <name evidence="3" type="ORF">Hamer_G008653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4F3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7173126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="230" mass="24930" checksum="C558AE3078B0AB0F" modified="2022-05-25" version="1" fragment="single">GAVVEGSEDCLLIDVSTPQLGYDSPLPVIVYVGGASLGGDTQRPWLLTKAAGLAKTKHVRQGLLGFFPHPKLAASTYPHTAGNQGVSDLLTALTWVQHNVEHFGGDPEQSIPARTVMEAPPLEWCHPQGHPWLLADGVIVPFIPSMPQVPLMIGSTEQAATHFLCSWQERLGISHQQLLVAAVDGLRLNEVNYGQPVWSGSPAYGHVNWPADKGVQNVWPSRTEMMRVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4T7</accession>
    <name>A0A8J5N4T7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010077">
        <property type="protein sequence ID" value="KAG7173330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4T7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="8654" checksum="E1AED97C3EFE49E4" modified="2022-05-25" version="1">MDRSPRRDRYSRRTISDQGPQQHLWAHGWWSKRTVKRTSAPTVSNLGCSMRRAVFLRTRRSWPVEPRYKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5R1</accession>
    <name>A0A8J5N5R1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008238">
        <property type="protein sequence ID" value="KAG7173991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5R1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035241056" evidence="1">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="45" mass="4866" checksum="B45EA8CFD2248753" modified="2022-05-25" version="1">MSLSWFLSLTVCPLEAQTNLLVGCARWTTGGRLPDTPAPAHILNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6E9</accession>
    <name>A0A8J5N6E9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G016398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6E9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="27" mass="3099" checksum="5E13E3D356F14774" modified="2022-05-25" version="1">MVPWWVRTLMATNTTKTENLHLVEIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6I4</accession>
    <name>A0A8J5N6I4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G016466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6I4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="143" mass="16207" checksum="6B15DF80C24F78E4" modified="2022-05-25" version="1">MTRPPSTSPPHNHEVLSVCEFWKKYNIKNAVDRIVEAWHKINVATVLHAWKPLFANSEVSEWSRADRGKRGEAVCGGNANEHSGDGAAVPAPRFSDVQVEDLQEIVGQHQQQLKKCWRRMKNNQNHKQHKGMTLSLVNLQHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6P5</accession>
    <name>A0A8J5N6P5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bardet-Biedl syndrome 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BBS4-L</name>
        <name evidence="6" type="ORF">Hamer_G015713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the BBS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007499">
        <property type="protein sequence ID" value="KAG7174590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6P5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186:SF1">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7174590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="441" mass="49403" checksum="60C0E741B9F3C523" modified="2022-05-25" version="1" fragment="single">VDVPVSLMNPVTETPESHVNGMTTSAVPPGSAQRSKIRPRKAPELQTVERRNWLIHLHYVRKEFDLCKQLIREQLEETRGMCEYANYVQNLKLQCKFRNMFHLMDCLQAFLAKLQIDKRKYFPENGDLHTALGLLYMQTGKHQQAFEHLGTTLTFDANNTRAILAAGSMMQSHQDFDVALAKYRVAAQSIAESPPLWNNISMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYTSAFHFLSAAVNLRPTKGHIFMLLAISLTYLDDEENARQAYEQAITLEERDPSVIENGAKLASLLGVDGSAFRKKASRTRLDALDETMHLEKMATTTDTLKPVEEVPRQSPPPAPEELNLPETSTGADDADLVSATQNLNINEPPAFDSNGNGVRGELLASAHLQFQEEKPKEPASDDIIADTAKSGDTDDSDNIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7K3</accession>
    <name>A0A8J5N7K3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007950">
        <property type="protein sequence ID" value="KAG7174083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7K3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="99" mass="10492" checksum="284A22BE0AB90542" modified="2022-05-25" version="1">MVGRVTLLTFHSRAESSVTWTAPGEHLTPSTTGEGGREGRPRHQQLPRLRIVVLGAEGVGKSGKDITPAAGAESRRDDESLLIMGGAPEVYVPNTCLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7Y3</accession>
    <name>A0A8J5N7Y3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">LIM domain kinase 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Limk1-L2</name>
        <name evidence="12" type="ORF">Hamer_G021255</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006462">
        <property type="protein sequence ID" value="KAG7174877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7Y3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000082">
        <property type="entry name" value="LIM domain kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF166">
        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1 ALPHA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="11">
        <location>
            <begin position="141"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7174877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="548" mass="62008" checksum="537B976D3A49E068" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N810</accession>
    <name>A0A8J5N810_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Coagulation factor V-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">F5-L9</name>
        <name evidence="1" type="ORF">Hamer_G023047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006389">
        <property type="protein sequence ID" value="KAG7174907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N810"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="147" mass="16301" checksum="CC0297446E2C9AF3" modified="2022-05-25" version="1">MFITGRKLSGFDWLGEAVSANFGEIEVSADFGEVEVSADFGEVEVSADFGEVEVSADFGEVEVSADFGEVEVSADFGEVEVSADLEVEVSADFGEELKCQQTLEEKLKCQQTLEEKLKCQQTLEEKLKCQQTLEEKLKCQQTLEEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8P3</accession>
    <name>A0A8J5N8P3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myeloid differentiation primary response protein MyD88-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">myd88-L</name>
        <name evidence="6" type="ORF">Hamer_G001253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8P3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070976">
        <property type="term" value="F:TIR domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035325">
        <property type="term" value="F:Toll-like receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002755">
        <property type="term" value="P:MyD88-dependent toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008063">
        <property type="term" value="P:Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017281">
        <property type="entry name" value="Myelin_different_resp_MyD88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15079">
        <property type="entry name" value="MYD88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15079:SF3">
        <property type="entry name" value="MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="5">
        <location>
            <begin position="156"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="415"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7175226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="467" mass="51786" checksum="B0366BBC7202C295" modified="2022-05-25" version="1">MPLRRKEVAEGPIRLLSFVTRQHMATRLDSRKVLLAAQGVHRDWRGVAEQANLDVSSISCWGKISPTEHCLHIWGQKCGTVQQLWNFLEAMDRFDVIDDTLEMIYADYDKCMSQGGGALAALPPPMDQLVSDVATYDSNVLTVDDHRNLSMGLGLQQYTALVLFADEDIDFVQEMVEKLEGDYGLKLCLKDRDLVGGLQFESDSIVRLIIERCTRVIVILSPEFLASSANNFFILFAHALSVDQRRRIVIPCLHKPCVKPAVISFCHSLDYYRAKGYWNYWEKLRDSLTFQPHVGSSITSGESRVRIREVSGSSTSSQVSANSLSVTTPSPSQSPNFFSKFLRRSDAKIGKSSLSESETNPLEASDQKTSAGSNGYPCSPSIPIREMSARPVLHLGPSSASGESSDYTAIFQSLPDVPETSPYNSPMNTTSSTAHLIPEESSANSRSPSKFFDKIFKGKPKKHRVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N987</accession>
    <name>A0A8J5N987_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006067">
        <property type="protein sequence ID" value="KAG7175451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N987"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="9658" checksum="77991373F70E3452" modified="2022-05-25" version="1">MRSLASGLTDSEGDGINCDETEKMGLDIQRSVDNQPNWPDHFMKKIDKYELASTIQMDLTNLIPKAEVQQLKREMPVIDGGWLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9H4</accession>
    <name>A0A8J5N9H4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Transposable element Tc1 transposase-like 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tc1a-L16</name>
        <name evidence="2" type="ORF">Hamer_G001410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9H4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="134" mass="15654" checksum="F8721AB5FC3180A8" modified="2022-05-25" version="1">MALWIKRHDDTGQTLHQLGAKQPRCTMPTLDRAIAAIIQNRPFTTAPSIRQELGLAYTSQTIRNRHYSNDLHAHMPSKKPHLTEVDMERLLDYALVYAEKPACFWEDVYCDEKTFSTDEMNSCTTRVWRRGNEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9M9</accession>
    <name>A0A8J5N9M9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutamate receptor ionotropic, delta-1-like 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Grid1-L33</name>
        <name evidence="9" type="ORF">Hamer_G025352</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003283">
        <property type="protein sequence ID" value="KAG7176495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9M9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7176495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="290" mass="32474" checksum="CC89C39AB00F17BD" modified="2022-05-25" version="1">MWKWSQVEVVSGGSGLRWKWSQVEVVPGRVRTHFNHLLPPSCPPFSLPTILLPTVLLPTIITLYPPSPLAHTAPLLPTVMRGLVQYVTLGVCWNMVGKLHDSSLPLAMAHLPTPGESDQQYLKSYLTRMESRNMVSHNLQGRDVPIALTNYPPFLHIIRERGGNKVMGRGMSWELMMTLANYFNFTPVPLVAEDDVIGLRSESGEWKGAMQLLDSKVLDFSLLLGTTTFGILAKRPKDSPKPDALLKPFSLEVWWLILAATAVMGPLIYFIIVVRVRLCKGDPRLTRVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9P7</accession>
    <name>A0A8J5N9P7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Angiogenic factor with G patch and FHA domains 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Aggf1-L</name>
        <name evidence="4" type="ORF">Hamer_G024761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005322">
        <property type="protein sequence ID" value="KAG7175602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9P7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16164">
        <property type="entry name" value="OCRE_VG5Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053027">
        <property type="entry name" value="AGGF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035624">
        <property type="entry name" value="AGGF1_OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17780">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="704"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="896"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7175602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="967" mass="108488" checksum="1BDBC3583522B48D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NB63</accession>
    <name>A0A8J5NB63_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NB63"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="68" mass="7689" checksum="BAAB052B72DDA622" modified="2022-05-25" version="1" fragment="single">KHGKVEGVWLNNYIKGPAAGLLNETRTFKKAAIVSFRLDRGKLVINADMKVICKLIVTSRKISRLFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NB67</accession>
    <name>A0A8J5NB67_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like-conjugating enzyme ATG3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Atg3-L1</name>
        <name evidence="10" type="ORF">Hamer_G016719</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002318">
        <property type="protein sequence ID" value="KAG7177426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NB67"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7177426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="102" mass="11447" checksum="0BED76671578FE39" modified="2022-05-25" version="1">MVMAASAPGFNRQPLTVEEMYEDFSQDHANKTVTMETHPHLSGPPMASVHPCRHAETMKKICETVLEGGGELGVHLYLIVFLKFVQAIIPTIEYDYTHNFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCB1</accession>
    <name>A0A8J5NCB1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCB1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12840" checksum="6ED9118F54AB261D" modified="2022-05-25" version="1">MDALLIHFIWIPSHIGLHKHDYVDNLAKSSCTLPIPDDASTITTGRVKTLLTQGSRSSIINKERSEQRGASVSVHHHDKHYDTKYKYGRNNCLTRLSDVVAARIKLGYRPSWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCE2</accession>
    <name>A0A8J5NCE2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">limulus clotting factor C</fullName>
            <ecNumber evidence="9">3.4.21.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Cfb-L1</name>
        <name evidence="14" type="ORF">Hamer_G008429</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds in Limulus clotting factor B to form activated factor B. Cleavage of -Pro-Arg-|-Xaa- bonds in synthetic substrates.</text>
            <dbReference type="EC" id="3.4.21.84"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.84" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCE2"/>
    <dbReference type="OrthoDB" id="6339870at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042381">
        <property type="term" value="P:hemolymph coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF54">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0353">Hemolymph clotting</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035243890" description="limulus clotting factor C" evidence="11">
        <location>
            <begin position="21"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="13">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="186"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7177755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="437" mass="47598" checksum="7EC69FF109D00B18" modified="2022-05-25" version="1">MNVCLLLLAVVSATVVQTWAEGVLFEPRSNTDTCTLDTGGTGRCVDVRECPPVAETIGVKMPVLCGFNDKYPIVCCPIPVDVVAEPSLDYSPPHVSFDCGVTFDRTVPLSYALGFTSDSNGKILRPGHNLTGLSFPGLLTGLTPGVIPTGVIPSRLPTGLTPGGRFQKRSLAPVNTRPPIDPDRPVVGGKTSNINAWPWMALLGEKKKNETITWFCAGALINEYWVLTAYHCFLFEDINIVRLGEHDYNTASDEAVPKDYTIDKVVLHPEFKFPASYHDLALVKLDRQVIIQGHIRPVCLPWGEDTKTQLEGQKVTLTGWGNTAYGGSRSSALQEVEVTVFPTPECEKSYSDLRDYPFNWPRGLGDEVMCAGDKAGGRDACQGDSGGPIVTKDSSNSYTLAGIVSYGYGCGKKKYPGLYVNVRHLPYLSWIKSIAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCM7</accession>
    <name>A0A8J5NCM7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Ionotropic receptor 21a-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Ir21a-L1</name>
        <name evidence="16" type="ORF">Hamer_G000386</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCM7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035265728" evidence="14">
        <location>
            <begin position="22"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="240"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7177143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="747" mass="84442" checksum="45A69419A9BB64DC" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCM9</accession>
    <name>A0A8J5NCM9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small nuclear ribonucleoprotein F-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SmF-L</name>
        <name evidence="2" type="ORF">Hamer_G000124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCM9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF22">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="116" mass="12633" checksum="0C04B46A6B86568A" modified="2022-05-25" version="1" fragment="single">MEQLIQEIKSSPTDMFAIQLDETMDVSSCAQLLLLANGITWENCCGVCSDGAPAMLGLKSGLQKHADENFLQLANTEEYIDGQSTGSLGEVLIRCNNVLYIRGVDDDDEEGGQMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ND55</accession>
    <name>A0A8J5ND55_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ND55"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="76" mass="8605" checksum="27B5F849010E46D5" modified="2022-05-25" version="1">MGEQRISIPTFNHNVEDWLSHVERSLIGSTATDLQKYTALICALPTDVATQVLEVISNPPAQDKFTTQWTALQNWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5SZM2</accession>
    <name>A0A8J5SZM2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C-1-tetrahydrofolate synthase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MIS1-L</name>
        <name evidence="1" type="ORF">Hamer_G018601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012106">
        <property type="protein sequence ID" value="KAG7171480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5SZM2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="102" mass="10726" checksum="92F5EE41D9B77CDE" modified="2022-05-25" version="1">MAGFSDLPICMAETRLPLMSDPRRRERPRAYTPVRDVGASVGELIVVMSATAVVLVEAAVVRKYGVAAVVAAAAEEEVYTNDTSLIFYRSCGGGGSRGGGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T6S1</accession>
    <name>A0A8J5T6S1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009918">
        <property type="protein sequence ID" value="KAG7173429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T6S1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="52" mass="5507" checksum="FC54C09DBB2EE6E3" modified="2022-05-25" version="1">MSGKEGVVWGIVWCVRLCGVGDCVVWGIVWCGSSVGDVSVCCEDAVRVVCED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIP1</accession>
    <name>A0A8J5TIP1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ras-related protein Rab-36</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Rab34-L2</name>
        <name evidence="19" type="ORF">Hamer_G022828</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Golgi apparatus membrane</location>
            <topology evidence="15">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010010410">
        <property type="protein sequence ID" value="KAG7172833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIP1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000707">
        <property type="entry name" value="RAB36, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00067830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG7172833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="247" mass="27511" checksum="3F9B481800AC0F9D" modified="2022-05-25" version="1">MQLSRSAVYTMLQTHAEKDRIIISLPPPFIRQASPHTNDDFDESVKNAALLNIDLSSRLCHQVFDANYKATIGVDFEVERFDILGIPFNLQIWDTAGQERFKCIAASYYRGAHAVMVVFDVTNIVTLAHTAQWLEEARQANLNSNPLVFLVGTKRDLMSEGAYNQIEAQAKRVAQGLGAEYWAVSSKTGDNVEALFLRVAALTFNRAVLQEVQGYDLQKFGDSFKIGEKLDNASEARKKSKCAACGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIW3</accession>
    <name>A0A8J5TIW3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyrosine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="4">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">yars-L1</name>
        <name evidence="20" type="synonym">yars-L3</name>
        <name evidence="21" type="ORF">Hamer_G001453</name>
        <name evidence="20" type="ORF">Hamer_G027167</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:10221"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010014373">
        <property type="protein sequence ID" value="KAG7170400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIW3"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000047">
        <property type="entry name" value="tyrosine--tRNA ligase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 17" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="19">
        <location>
            <begin position="808"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="778"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG7170400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG7175380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="971" mass="108063" checksum="E53F6216C33D97A0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJ60</accession>
    <name>A0A8J5TJ60_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G026330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004582">
        <property type="protein sequence ID" value="KAG7175921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJ60"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="423" mass="46827" checksum="76E94DA545015BDE" modified="2022-05-25" version="1" fragment="single">MVLAKFMSWQKKGERGVVWARVIVQLIMLLILVVEKTATTTTLSSRLVVGPKSPYCHSQKSDLVCNFTGTQEPVYVEESLFLEDKVKASQTVKIIDPSVLHLSHVMSLKNMIIYEAGKVLVSTVSKSTHTDNCTLRNLQIFKSTVTNIPSNVMHLTVISSKVTYMELQPCIQHVSLVNSHIKFFRTIAPLHDSAILKVASSTIDHIEEVWTSANANLHFLTSTIICIRMEKVRLGQNTSVFIRETMITPMNSTDLRISPGTKVTLQKVNGTLTMAAATEEEFSGSSTCQQPTAPTPPSLPPETTTIIYWNQFMTYLILTFTLSIIVILILLLGRSVSYNIQPSSREALRDMEDNDSLREPILPGGGGADRQEGTYQDRARHCHLSDDNLLSSAATHLDTETATHLDTEAATHLDTEAATPTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJX9</accession>
    <name>A0A8J5TJX9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009960">
        <property type="protein sequence ID" value="KAG7173387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJX9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="356" mass="39277" checksum="FA0242A3D2B6B7D4" modified="2022-05-25" version="1">MWEDGVEVKEELPKKVRAEEVPPSTAPNPYAPYDHLLYMWRCAAMAPSWTATPLVTRDGKVLPPPPPAIVRDSVPAPVPAYLSQGPPVLADPGRVVPLSDSLKFERHYQPNVALAPPKVRDKAFRESLPTKDISPGELIHDAHDNKLAVFLQIGKPVEVECIKRETSPVPPLCHQPSSPTTTHSVNRPTQTHQHTQHHQPRKICSPDTSGRHPELELSTTDSDTDSVGSVGNHSETVEEAEGLLRGWSDRAAAGKVAQLVADLVARLAASDRQKAALRQRLDAQTRDHNHTVATLRNQLMVTTQHNKDEDQLREKVCEMEGELRALREELRPRPPPSVIAPTSPVKTEPSDVTDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TM00</accession>
    <name>A0A8J5TM00_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Keratin-associated protein 12-2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G028445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002347">
        <property type="protein sequence ID" value="KAG7177375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TM00"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="274" mass="28766" checksum="F7374D3146117115" modified="2022-05-25" version="1" fragment="single">MEKSQLSAIHHQPLSSLSQLSACPASPCRCQPILSTPCPAVSNSANHVSCQLILPTRRLSSLLCQPASCQPALPASQLSGLPSQPVICQPGLLAPVGCPASPAPTPVSCQPTLPTPVSCQPTLLTPVSCQPTLPTPVSCQPTLPTPVSCQPTLPTPVSCQPTLPTPVSCQPTLPTPVSCQPILSTPVTPCYLLSPTVTPRHLTPLYTLYLSLTVTHRHYGSYLSSSVTYRHSPSLSVTLCHVGRSGEVGRWGVRKGQEIRGEEVRIMGVSVGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TM12</accession>
    <name>A0A8J5TM12_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TM12"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="81" mass="8888" checksum="AB801F5EEA6ED7C0" modified="2022-05-25" version="1">MIEQTTRAMTSSPVVCHIGETEALHLTPHSQSFPHSYTSQRVNPSLLHLTGSPSLILHITASPCLTPTHHSESFPHSYTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TMQ6</accession>
    <name>A0A8J5TMQ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TMQ6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="78" mass="9117" checksum="B267DD6E5711E649" modified="2022-05-25" version="1">MDMNPEQQVMGRRMKMLVPTNDALLKPKQCSLDKERWLMQNKRSTVAERHQDHILLRPFSVGEVVRMEPIDNKSGRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TN82</accession>
    <name>A0A8J5TN82_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004742">
        <property type="protein sequence ID" value="KAG7175697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TN82"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="127" mass="14803" checksum="24E79C5DC4D71F91" modified="2022-05-25" version="1">MPKLTATRCERKPHLLQRRKGVPRPSQSTQYSDSGRTCRCPRMGQPVRTCLSEHLGARERLKTNKYAKKRGGPTQVKNRQIWKTGRRREDRRGGKKPPLLPRTCPTLNREKKRPSPIQEHTEVGRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TNW2</accession>
    <name>A0A8J5TNW2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nucleolar protein dao-5-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Doa5-L1</name>
        <name evidence="3" type="ORF">Hamer_G008990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TNW2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7176223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="678" mass="74137" checksum="1AFBAB175023553F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JAY2</accession>
    <name>A0A8J5JAY2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative spidroin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G020064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045843">
        <property type="protein sequence ID" value="KAG7154004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JAY2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035194864" evidence="2">
        <location>
            <begin position="39"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="478" mass="48650" checksum="8E96024DBD202792" modified="2022-05-25" version="1">MSLEAEEETTQLQRQWTTRGSMREKLAILLVVVGVTWASGEEPETDRLPRQTSGYVISQPFGKLILGSGAGLLGSHVRLGGHVGGHGGHGGGHGGGHGELGGGHGGHGGGHGELGGGHGGGQGGGHGGGQGGGHGGGQGGGHGGGQGGGHGGGQGGGHGGGQGGGGQGGGMEEDKVAGMEEDKVAGMEEDKVAGMEEDKVAGMEEDMAAVALEAAAAVVNHLSRLRVHQKTRVEFMLNGQLQGSYSVLSSDGIVRTTVYSDDGTSGFKVSVHEDPIDVVAVGSGLPGDPGVGGQGGGGGVVLVGGRGGFGGGQGGGGQGGGGQGGGGQGGGGTRRRRTRRRRTGQGGGGQGGGYRRRQDKEEEDRRRRGDKEGGGQGGRRTWREEDKEEEDKGGGRTWRRRQLGGGHGGGHGGGDMEGGHIGGGQRREEDKEEEDKEEDMEEEENRRRTGGGGGIGGRRRNRRRRRRTWRRNRRREEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JBG9</accession>
    <name>A0A8J5JBG9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041065">
        <property type="protein sequence ID" value="KAG7155577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JBG9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="564" mass="62152" checksum="B62A996D88E190AC" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCU7</accession>
    <name>A0A8J5JCU7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA recognition motif-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G030709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047013">
        <property type="protein sequence ID" value="KAG7153430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCU7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="89"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7153430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="153" mass="17646" checksum="179CF7DE7ED38C2A" modified="2022-05-25" version="1" fragment="single">TEHSLINTAQHGFIERKFCLTNLITFLETLTVTDYVTKAHHYRLRDQGSPVDVLYINFSKTFDKDPHARLASKILAYGITGKILLFDQYGLFIKHIPSEVTYRKMRSLFSHCGGLVNFFMPCDHQTGLHRGTAIARYCSEFYREEALRLNGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCZ3</accession>
    <name>A0A8J5JCZ3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Interleukin-17-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039966">
        <property type="protein sequence ID" value="KAG7156132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCZ3"/>
    <dbReference type="OrthoDB" id="6368205at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035307719" evidence="1">
        <location>
            <begin position="28"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="223" mass="24809" checksum="44960F0C03FCBFEE" modified="2022-05-25" version="1">MVVQRVLYRQPAVTSITLACLIHAVLATPTANSPHNLTINSLAGNVLTVHSPAAFMEHFDSQMPINWLQPEMICSPAELMNDHFSRYTAFPLSVITFNLVNACQNLQENREVVVLEDRHQLSPEWLAHATVLGECPWELVRKDFIPGIVPPSIIELGCLCNDHRCSLVGNFKCIPVSRSVRIWNRGPHSCGSYHPQTVKVTVACVCAQPHSPRGGEAQPFLWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDM7</accession>
    <name>A0A8J5JDM7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">KRAB-A domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">KRBA2-L</name>
        <name evidence="1" type="ORF">Hamer_G018510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043933">
        <property type="protein sequence ID" value="KAG7154781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDM7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="129" mass="14848" checksum="1E09CF90C17A24B5" modified="2022-05-25" version="1">MDGRKERFDLVLAQAEKEKSYNASSLLPRREYESNVDRLMELEKPEVKRTQMDYRLLNKYAVMEISVEGTTVQKLIKKGTALQYVCAEALFDTIQTAHLANGHVGRNTLYKATSEKYANITIAQIRLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFQ9</accession>
    <name>A0A8J5JFQ9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BRSK2-L</name>
        <name evidence="16" type="ORF">Hamer_G020563</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010039068">
        <property type="protein sequence ID" value="KAG7156481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFQ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048622">
        <property type="entry name" value="BRSK1_2-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF36">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BRSK1 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21122">
        <property type="entry name" value="KA1_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21115">
        <property type="entry name" value="UBA_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035275909" description="non-specific serine/threonine protein kinase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="118"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="373"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="170"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="427"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7156481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="465" mass="51251" checksum="027E0E5DB47CD12E" modified="2022-05-25" version="1">MLSIVVILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQDLLRGMIEVNPEKRFTGELELEKPMMEVVQTHIIPTKDSIDPDVIRNMASLGCFKDKDKVMLDLLDPWSSHTLPCSRRRSGNNNSGSHSPLHSNNVTPTASPLSSPRTSRHHHSQPHYHHHHSSTTSSTSTSGVSTVVSSTSSHQQSGTITSGDDSNPPSAPGSPYSAPYWKSRLNTIKNSFLGSPRFHRRKLQVPTDEVHLTPESSPELTKKSWFGSLMSTERDETYTILVKDKALATVKADLIHAFLSVAELSHSVTSPMSFRVEYKRGSTGPAMFQRHVRFQVDITPVCSPNDPNPLYAINFILLSGNIRRFRRICEHIQAQVCSRRPPASPRVGRKFTTELSESSSCGSDTSERLSPFPPGKQTESDVESDVSQSEGKNLSSGRGGTDSPQPNVSNGRSTSDPETQQLGSSELAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JG88</accession>
    <name>A0A8J5JG88_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Actin-like 38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Act-L38</name>
        <name evidence="12" type="ORF">Hamer_G006715</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JG88"/>
    <dbReference type="OrthoDB" id="6329464at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0558">Oxidation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7156721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="376" mass="41632" checksum="6E7702DC9A411951" modified="2022-05-25" version="1">MCDDDATALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEESPTLLTEAPLNPKANREKMTQIMFETFSCPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFENEMAQAAASTSLDKSYELPDGQVITIGNERFRAPEALFQPSFLGMESVGVHETVHCSIMRCDIDIRKDLFANTVMSGGTTMYPGIADRMQKEITNLAPSTIKIKIIAPPERKYSVWIGGSILASLSTFQAMWVTKEEYDESGPGIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JH81</accession>
    <name>A0A8J5JH81_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peroxidasin-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Pxdn-L5</name>
        <name evidence="8" type="ORF">Hamer_G021012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037948">
        <property type="protein sequence ID" value="KAG7157126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JH81"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000003">
        <property type="entry name" value="chorion peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF106">
        <property type="entry name" value="CURLY SU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035281759" evidence="7">
        <location>
            <begin position="19"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7157126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="756" mass="85137" checksum="143D677E2A2E4F2E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHP4</accession>
    <name>A0A8J5JHP4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G008955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHP4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="118" mass="12866" checksum="12B8830085D84DA0" modified="2022-05-25" version="1">MGGRCLVQPSSSSSSSFPFSSSSPGFGLNTTDLVHDAVEHKVAEDEVTTPARLRRRVEHFILCSPQEEEGASLNLKEHPLTCTLDKLTWSADKETFSDVYVTGNTHLTRTQGDVKVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIE0</accession>
    <name>A0A8J5JIE0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Transposable element Tc1 transposase-like 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tc1a-L32</name>
        <name evidence="1" type="ORF">Hamer_G006746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIE0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="61" mass="7436" checksum="3AB6AADBD6C9ACAB" modified="2022-05-25" version="1" fragment="single">MSERLTEQQFAQQYVGEDLESLSRIVFTYEKTFVSTYHGKIHLWRPNRTRYDRAHIFEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIE2</accession>
    <name>A0A8J5JIE2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G006600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIE2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="138" mass="15364" checksum="5B7A5BD3F1EFCE57" modified="2022-05-25" version="1">MRKQHNNHTFPETSPYSTLSTTAATKSGSYSQPRSTYRYWEGAGLYAGGLTSYLHLLLWMARLRCGQTFAENTDQRCLDEVVVMTMDSALSGFDHWQKSQKPYESHESSPAGIVAESHCSLTSPFTSLLTSPFTSQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JL00</accession>
    <name>A0A8J5JL00_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JL00"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="291" mass="32634" checksum="73BC545055BC2AF1" modified="2022-05-25" version="1" fragment="single">MMLQGKSVLLNFRANCQRSDDTIDAVDRDSNGSYAVKVIKAQAFNELLDYIEEHRGSGIVLSMAKLTALYDKRLLSLGCPHNHAIEKSSGCRELAFNEDLSKVDKEMKDTTSTDMRILAQAAKIRRRDVIVLSLAQTIMHNSVGKKSPHPQSVSRHRRERETPVSLMLAKKVHMKTGHQRSLRDRGIENIDYNPSSITASSQSMLHGTSISILQHFSSDQGEKHQDAILKAAEMGQKTVRPHPVSYTTLENVSLSKDEIVHAPPLHDINSHPDHASRSLQQILQDGYQWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLG5</accession>
    <name>A0A8J5JLG5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Matrix metalloproteinase-24-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MMP24-L</name>
        <name evidence="15" type="ORF">Hamer_G026795</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032692">
        <property type="protein sequence ID" value="KAG7159706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLG5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF294">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="14">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="12">
        <location>
            <begin position="208"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="12">
        <location>
            <begin position="306"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="12">
        <location>
            <begin position="353"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="130"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7159706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="437" mass="49729" checksum="8AFA69F5567FC0FE" modified="2022-05-25" version="1">MKMMNKLGSDGYIFDGPGRVLAHAFYPGPRIGGDLHFDDSENFVAHHLREKYKGKSLLITAAHELGHSLGLRHSDVENALMAPYYQDFPEDLKLPFDDKYGIQTLYGRPQSHYTTATLRPPTTPYITPFLPRTTPYKPQTLPPVTLPTNPHFPPTKPTTTPTTKPTTTPATKPTTTPTTKPTTTPTKPIKPSDDVPCPAGDPPQDGPPDTCDTDFDAVIKFHGEFYFFKDGYYWRISRKGYMYKNESPNRIWNRFPGLPTSMRRVDAVYVSRENTLIFFGGSSYYELGRSLRLKTTGKLTDLGVNVSYLDTAMVWGHNGRIYLFSGDHYWRLGTDGRAEPDYPRDVTVWRGLPRNYSAAFTVRSSTYFLSGHVFWSFDSLKMRISEPPSLIAPYWFSCPYYKQNKLRHCFPSSAPMTHPNHLLHLYIWIAILCLTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMF5</accession>
    <name>A0A8J5JMF5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040383">
        <property type="protein sequence ID" value="KAG7155799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMF5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="109" mass="11915" checksum="1534793BE22683EE" modified="2022-05-25" version="1" fragment="single">NPASGSVLQASRLTNPDAPQETDNAEEKGVTEQTPAATVHETNEADKAKSQMIETSTQSTIERQELQNNIQRETGTVRKKVTTATMDIQGEETLLTLECADDCELQLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMS4</accession>
    <name>A0A8J5JMS4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G016259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMS4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="217" mass="23962" checksum="147ACE36FD73BE4F" modified="2022-05-25" version="1">MADAILPWVSYMNNKEKKVDSSLLLTTYTQQYLEIRTSDAEDGPVDGEDGSLEHQVNICAVLVVEEVTQVLFVGRGRWSSEFHLLPRPWFSVASPTQQSSTGAENDFSCPSAASTPSATALAGYSYSQGLTTPLGYLQYNLTYFSPVITRTAGPPLLPRGPSDLNFCYISQYYTHHVRLKMEPRFLRCGCIPAIMSHHQRRGDTGGGGGGAWCSRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JN57</accession>
    <name>A0A8J5JN57_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JN57"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="164" mass="18768" checksum="E025E5076B6EB428" modified="2022-05-25" version="1">MWRFSEDDGDVRSKKRLEGMGSGGPEENRQGTDDIQQQETKKLDYVEAIKKPSITDSCRWINKFLITINTPRTGLWRFSHNVMDTVRLWVKRYKEEGHAAHRAPTRKTKSHHTSGRSTDSKGSRASTTVNCHAYNEGNRSSVSPNNYQEANTGDWPTMFHPSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNJ0</accession>
    <name>A0A8J5JNJ0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036894">
        <property type="protein sequence ID" value="KAG7157783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNJ0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="114" mass="12146" checksum="D3DC17232395BCCE" modified="2022-05-25" version="1">MTAALARPHLPSAHATQNTHASSFQKVGVGLELSEDHLWASFHTTSEMTVCIAECAIIAIRASIHTFSSRQVETGEGVMCHLARPSSDPQLLLQVASGGDLAVWSTHVSTVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JP01</accession>
    <name>A0A8J5JP01_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G020672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035785">
        <property type="protein sequence ID" value="KAG7158068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JP01"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="181" mass="20008" checksum="7FB3D7742CF8B9E9" modified="2022-05-25" version="1" fragment="single">STTGHKEPFVSTLPSVKLFPPIDTVPTRPQRFSRGSSSLLPQTLRDVTLRSSATDGILRVKLVDLGRMEYKIVSWIFIPSIFTFNSYNEVRSLSPPQFIFWYHNNKMINYDQSRGGITVTMDHQDLTTSRLTISDKTAAIQRLGSGSQGLANATGATLVSLLLSLQLLLLCFTNLVVSTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ30</accession>
    <name>A0A8J5JQ30_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G025657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031515">
        <property type="protein sequence ID" value="KAG7160248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQ30"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="112" mass="12660" checksum="B1C4BE076C8EAE0F" modified="2022-05-25" version="1">MAVTGNKKTSVFSIHSLKKAVKKLIKKTRPTKEVKKVEEVKTVYRVDFEAEIEDNLANEALEARFIQIIEASPAVLDLNMSLKGTLMVKTAPELDVQFGTFWTTDDDESWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ34</accession>
    <name>A0A8J5JQ34_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028443">
        <property type="protein sequence ID" value="KAG7161986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQ34"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="310" mass="34256" checksum="E9525851A0797155" modified="2022-05-25" version="1">MLPPTLSHAPSLSPRSLSPAPPLSHTPSPPSPHAPLTSPRSLPPLTPLPHPPVAGVVRGDGVLSYFIALSNSALNPIIYCGFNDNFRKGHVSPHLQTLSTGRIHHRREYNCVQTAGYTTVVSITGQTAGYTTVVSITVSDGRIHHRREYNCVRRQDTPLVSNCVRRQDTTVVSITMSDGRIHHHRYTVVSITVSDGRIHHRREYNCRQTAGYTTVVSITVCQTAGYTTVVSITVTDGRIHHRREYNCVRRQDTPPSSGQKCSLTSTHSGRVLRTSLEKDLDHNNLKDDALDPTCEVLLRSLLTHVYISQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQM2</accession>
    <name>A0A8J5JQM2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Synaptogenesis protein syg-2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Syg2-L2</name>
        <name evidence="8" type="ORF">Hamer_G008116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQM2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="6"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="133"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="235"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="339"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7162552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="506" mass="54090" checksum="9CFCD64A7A691E93" modified="2022-05-25" version="1" fragment="single">MDRPVPAGLLGPLTEGEPLTLYCVATGGWPVPEVTWWRGSTLLANHSLILGHNGPISTSSSSSSSSSHASSPSHASSHAPSMVGAGVRQVRTEVSVPALSRDYVHANLTCRATNNNITEPLSTTLALLLYLRPKSVSIRSPQSPLVEGQEARLECVAEGAYPAATLSWTLTSPNHDVTTALASTSRHLGDRTSSFVKVKPAAEDHLATLTCTAFNPNITAPGITTTTVIRVVFAPRVRLELGANLGNEPITEGKDVYFECEVDANPPTWDVIWRRNMVRRSSAGNYTCTAANALGSTISNPVNLDVRSPRDYGTLSCWATNAVGTQADPCRFTVIEAGPPERVDKCVLVNLTSGSLEVGCTPGNDGGLKQRFVARVYAAPTHALLATLEEDTPRFHVGGLTPGQDYLITVTAVNAKGASLPQQIDAVRLKVAEKRMVEVGGSSPPVSPLVGVFLGLVGGFVLLLLAGVLLTRARSNRLMKRKMSRKCRIIDERCIKLPENDRKTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQT8</accession>
    <name>A0A8J5JQT8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative olfactory ionotropic receptor IR4-like 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ir4-L11</name>
        <name evidence="2" type="ORF">Hamer_G007956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQT8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035258366" evidence="1">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="179" mass="19989" checksum="9C2554FA005605A3" modified="2022-05-25" version="1">MVSVLTPLFILVFIAILTMAQLKAPKMESESLSLANEVVEAVMSRVSMLHCTVLFFTDATTSSTTFFNVINHLRASRGVGVFEAASNGHDKNKTLFRLMSEARRLRQISLCVTVAVVSDDSAFLAAFAEWSLKGRLLQWSTRLLAVTRLPLSDLHHLHEFFSINNAMLLIMENNFGKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JS55</accession>
    <name>A0A8J5JS55_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JS55"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="137" mass="15467" checksum="5E8E38C50BB0478D" modified="2022-05-25" version="1">MLEEDEEQEQQPTQEDDVKPGEPTTLQLTELLTNIARLGEQLEEYDTGPHPRNLMCSALDKGMEEYKALYMSRVNASQQALITLYLCKAQPVINALANITLGDDDGTTDDDIEVLGDLLEEEMPKTLRDLMLRLEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSN4</accession>
    <name>A0A8J5JSN4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Paired domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030192">
        <property type="protein sequence ID" value="KAG7161065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSN4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11978" checksum="B6032842103A00DD" modified="2022-05-25" version="1">MSRRVITRGNIATVIALYKGNNELREISAQTGVGLRVVQKIVKRYRELGEDMLPAPLPKSGRPEFLSSLTLEVISRQVKSNPALTAREVKERNPRLLSHISLRCVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JT97</accession>
    <name>A0A8J5JT97_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vigilin-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">vgl-L4</name>
        <name evidence="3" type="ORF">Hamer_G003019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JT97"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7163767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="88" mass="9946" checksum="B03A408545A3C0C0" modified="2022-05-25" version="1">MIDEEKERRRVTTPVSRTLSIPKSQHGKIIGHHGQNIRPFIQSLKINIRFPNKNDNNDKVIITGLPNQVDQGINHLLSLVTSFPPCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JU17</accession>
    <name>A0A8J5JU17_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030141">
        <property type="protein sequence ID" value="KAG7161069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JU17"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="116" mass="11903" checksum="23A8AF9D012E18B9" modified="2022-05-25" version="1" fragment="single">IVRLRGERLTEVNVWLVENSSKQVKYISDGEAVTLPAVVDFSIQPLYCRLHISASASTSASASTTTNASTTTNASPGANASPGANASPGTNASPGTNASPPVQTPSLNKPPEAFPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUL2</accession>
    <name>A0A8J5JUL2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUL2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="574" mass="62466" checksum="6F335017B2DA36BC" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUN2</accession>
    <name>A0A8J5JUN2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G014039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUN2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="107" mass="11430" checksum="8BC15BE4F5DB500D" modified="2022-05-25" version="1" fragment="single">DINKLFIYQYKEININELLSEYQEIETSNVSIANPDRLQQLQEEIALDAAKTAAAAAAIDAGAVGGVPDGAVGGADAAAVDIDEELFDGDDEDLDELDEQLEEMTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV01</accession>
    <name>A0A8J5JV01_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CD209 antigen-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Cd209-L7</name>
        <name evidence="2" type="ORF">Hamer_G014157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JV01"/>
    <dbReference type="OrthoDB" id="8950604at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21407:SF1">
        <property type="entry name" value="RE43931P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21407">
        <property type="entry name" value="RE43931P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="87"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="264" mass="29938" checksum="8BF41806126DD4D2" modified="2022-05-25" version="1">MGVMVAHPLPTTPWPGSALRQRVRRLSPVTQRSSSRQVVDPTALLARMLRVCVVLALLVVMVMGQGRELIRPDPKACKNRIKHAATFRNGHYYFFSWLHGPTQKHERDWLDARNICRKHCQDLVSIETQEENTFVKNALGEGNVKYIWTSGRKCNFDGCDRPDLKPTIINGWFWSGSNGRIPPTNSTFGWNGDWSRTGGGNQPQPDNREFGENGTDEACIAILNNFYNDGIVWHDVACHHVKPWICEDSEELLGFARSLDRSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV18</accession>
    <name>A0A8J5JV18_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neuroblastoma-amplified sequence-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nbas-L1</name>
        <name evidence="2" type="ORF">Hamer_G014191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JV18"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029145">
        <property type="entry name" value="NBAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15492">
        <property type="entry name" value="Nbas_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neuroblastoma-amplified sequence N-terminal" evidence="1">
        <location>
            <begin position="84"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1061" mass="120214" checksum="EE8D3BF4219DE1CB" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXH4</accession>
    <name>A0A8J5JXH4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein timeless-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G011089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the timeless family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXH4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009649">
        <property type="term" value="P:entrainment of circadian clock"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007725">
        <property type="entry name" value="TIMELESS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF5">
        <property type="entry name" value="PROTEIN TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05029">
        <property type="entry name" value="TIMELESS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless C-terminal" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="977"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7166260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1264" mass="143176" checksum="BE32A0667581BC30" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JY20</accession>
    <name>A0A8J5JY20_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Titin-like 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ttn-L17</name>
        <name evidence="2" type="ORF">Hamer_G014314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025553">
        <property type="protein sequence ID" value="KAG7164178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JY20"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="342" mass="37727" checksum="38B94DB17FF93745" modified="2022-05-25" version="1" fragment="single">VLVVMVMAVAVTSALGPHTGYQQARSYALGPFRSQQVRYYARGPNISRNYRRKWRCPRQISCPASNPYYNPCCRPPPPLPPWYPTYPPTLPPTPPPTLPPTLPPTLPPTPPPTLPPTPPPTLPPTLPPTLPPTPPPTLPPTPPPTLPPTLPPTLPPTPPPALPPTPPPTWYPTYPSTYPPTPPPTWYPTYPPTYPPTPPPTYVPLPPVYPPQPPLPDTINFFKNYLLPATTALNNSLHVELIPYGKLNQCANSHPDKIDALHRCSVGMEGYQLFQDAGKRQQQLAPVLKQLPMVALDEVLVIRSPEELQNFHQLLCDRLQGETEAQAFCRGVLARRQNLGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZ70</accession>
    <name>A0A8J5JZ70_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">F-box only protein 43-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Fbxo43-L</name>
        <name evidence="8" type="ORF">Hamer_G011136</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZ70"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045835">
        <property type="term" value="P:negative regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007088">
        <property type="term" value="P:regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20348">
        <property type="entry name" value="BRcat_RBR_EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047147">
        <property type="entry name" value="FBX5_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044064">
        <property type="entry name" value="ZF_ZBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15493">
        <property type="entry name" value="F-BOX ONLY PROTEIN 5 AND 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15493:SF9">
        <property type="entry name" value="GH14043P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51872">
        <property type="entry name" value="ZF_ZBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZBR-type" evidence="7">
        <location>
            <begin position="478"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7166306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="549" mass="61087" checksum="99661D7F4A06100E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K089</accession>
    <name>A0A8J5K089_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G010131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K089"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="165" mass="18355" checksum="3B57DF99A87AEFA2" modified="2022-05-25" version="1" fragment="single">QHSHNKLNPQKKSPRATAAEARSGRRTRRTTVDRRSGDGSASAALRRKTIVENISRVGVARRESETSFLCGPATRRNPAEDAARNAGVAVADESADTSPRRIVRSARRSGLDEDIRELRTKTLVDRGRRRRSTREEDAPEHGKNTTLAIAGRYSSTQKRMRITIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5B9</accession>
    <name>A0A8J5K5B9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Jerky protein-like 44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">jrk-L44</name>
        <name evidence="5" type="ORF">Hamer_G013358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015640">
        <property type="protein sequence ID" value="KAG7169726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5B9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7169726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="7796" checksum="BB6521DD080882DF" modified="2022-05-25" version="1">MAEAPPNMPPPPAPMPGPATQRQIKKRKSLTYAEKLEVVKQIDGGKSKRAVALTYGINESTIRGIYKMKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K614</accession>
    <name>A0A8J5K614_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tigger transposable element-derived protein 2-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIGD2-L5</name>
        <name evidence="5" type="ORF">Hamer_G002340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K614"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="56"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7168318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="275" mass="31591" checksum="FEF96783B7D1FEEC" modified="2022-05-25" version="1">MKREMLEMIKSGDRTYKIMRRFNCPESTTRFLKKNKEALTASVNVFSRFSRNRTFFDTSQRNLLLVITEHYLHKWVERRNCDQGDLSGPQIKHQARVYYAAIAQKKCVNSPPPFNASVGWLAAFKKRYEVKFAHYHGERASADVIAVLFTANASGDFLMKPLVVNRAARPRSYRLANMSQLNVYWIIVEAWHKINVATVLHVWKPLFANSKIIEAEQTEASVERQSVAATLMDTVEAARSVPAPGFSDVQVEDLREVVGQHQQQPTIEEMLEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6V9</accession>
    <name>A0A8J5K6V9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GILT-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GILT1-L1</name>
        <name evidence="6" type="ORF">Hamer_G010096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6V9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7167713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="189" mass="21152" checksum="44F4E4F2D09A4F3F" modified="2022-05-25" version="1" fragment="single">VSGGGRGRVKVTVYFESLCSDSMKFFKDQLYPTWRDLQDIMDLEFVPFGKATATPTGTGDYEMECQHGPNECYGNKVMTCAQNSLTIATQMELFHCMMTKPYPAFTGEQCSREVGVDWAPIDECSKSTVGSGLLYKNGVRTSSLKPRVYFIPTVTIDGHYNRNQLRTSLGDLKTQICEVYQGPPHQNCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K753</accession>
    <name>A0A8J5K753_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Facilitated trehalose transporter Tret1-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Tret1-L12</name>
        <name evidence="10" type="ORF">Hamer_G016823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020459">
        <property type="protein sequence ID" value="KAG7168190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K753"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="88"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7168190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="554" mass="59781" checksum="E392B1B8AEE002B9" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K828</accession>
    <name>A0A8J5K828_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G026202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018170">
        <property type="protein sequence ID" value="KAG7169154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K828"/>
    <dbReference type="OrthoDB" id="6377918at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035246752" evidence="2">
        <location>
            <begin position="21"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7169154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="215" mass="23735" checksum="453C8ED94BE1F46C" modified="2022-05-25" version="1">MVALVNLLVLLPLLGHAALGLPLLADTNEPGRRGWPLTMQPSPRASFNNDSLQTLQWLRALLGDRPESSAFIDGDDTLSERPYTPPMPLSRTHHNPSLAKRDQPAKIPTMGLGKRSPPYVQYVSLAGPAGVLSDMRNFFNELRTNLDSVEEVARSQENIGLLDRQQFLNLLAKYEAHMQTNDKGKGHPPPSANTRGRVFGYSNYDQPYAHSGLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8J6</accession>
    <name>A0A8J5K8J6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tigger transposable element-derived protein 1-like 194</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TIGD1-L194</name>
        <name evidence="2" type="ORF">Hamer_G029527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016928">
        <property type="protein sequence ID" value="KAG7169391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8J6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="158" mass="18107" checksum="CE25ED41C916FA3E" modified="2022-05-25" version="1" fragment="single">WKEVTVRCLCAAWSQLWPECVLQRDFEGFEELEEEAVVHEIVSLGNSMGLEVDDDDVEELVEEHSKELSTKELLELHKEQNETLKRSLTSEESGEEDKEESRIIPAKDLKDAFFCWSKLSKLAEDYHPDIGSVQKAISEWQVRRTPTGLNCGPEPTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8N0</accession>
    <name>A0A8J5K8N0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein Dr1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Down-regulator of transcription 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Negative cofactor 2-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NC2beta-L</name>
        <name evidence="8" type="ORF">Hamer_G002624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NC2 beta/DR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8N0"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7168538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="169" mass="19374" checksum="CAAFD83F36E11128" modified="2022-05-25" version="1">MSVPADQPDDELTIPRAAMNKMIKEILPNVRVANEARELILNCCTEFIHLLSSEANEICNQQQKKTINAEHILKSLDTLGFGDYRAEAEAVLKDCKAMAAKKRRKSTRLENLGIPEEELLRQQQELFAKARQEQMLMQQQEWQMVQAQAAAAQQQQQEQQTIDDDEDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8T7</accession>
    <name>A0A8J5K8T7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Hamer_G020517</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Photoreceptor required for image-forming vision at low light intensity. Can use both retinal and 3-dehydroretinal as visual pigment. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Signaling via GNAQ probably mediates the activation of phospholipase C.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Interacts with GNAQ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Cell projection</location>
            <location evidence="18">Rhabdomere membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019403">
        <property type="protein sequence ID" value="KAG7168715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8T7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15079">
        <property type="entry name" value="7tmA_photoreceptors_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000044">
        <property type="entry name" value="Opsin, ultraviolet-sensitive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00238">
        <property type="entry name" value="OPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00577">
        <property type="entry name" value="OPSINRH3RH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10 20" id="KW-0157">Chromophore</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11 20" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4 20" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="6 20" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="15 20" id="KW-0807">Transducer</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="21">
        <location>
            <begin position="73"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG7168715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="377" mass="41871" checksum="57E770C646AA3E95" modified="2022-05-25" version="1">MAAGTVNVSGVLAYRAGGVAFGYPEGFTLMDMVPDDVKPLIHSHWNKFPPVNPMWHYLLAGIFIILGILSFFGNGMVIYLFSCKKSLRSPANMFVVNLAFSDFMMMVSQFPMYVMNCFGGGYWILGAFACQVHAFTGAIFGLTSLLTLAAIGYDRYCVIVKAFDGGHISSGKAFFIILLCWGYSIAIAIWPFFGWNSYIPEGILTSCSFDYISQDWGTKSFALFLFIMCYCIPLTTIIFVYSQIVSAIRQHEKALRAQAKKMNVENLRSNVDANKQSAEVRIAKVAVANVFLWVLTWTPYAYVVMMSLFGDQSKVTPLVSALPGLICKTASVYNPIMFAISHPKFRLALQETLPWFCINEPKVDSISTDGESTVSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K9M3</accession>
    <name>A0A8J5K9M3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013566">
        <property type="protein sequence ID" value="KAG7170772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K9M3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="170" mass="19292" checksum="2BFBB6D573B544AD" modified="2022-05-25" version="1">MMIRELERGGDLVAASGDTSDRLTLVGLSKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDIDSPSRVTSSSLSPRGHSSARGDADHCKQIYRLFSHSVFYLPPTLKRRVRTIGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KA39</accession>
    <name>A0A8J5KA39_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cationic amino acid transporter 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Slc7A2-L</name>
        <name evidence="4" type="ORF">Hamer_G018053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015512">
        <property type="protein sequence ID" value="KAG7169796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KA39"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF17">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7169796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="151" mass="16318" checksum="0A2E03ADA6F83051" modified="2022-05-25" version="1">MGRSLPFLAPGLPWVPAVAIIINVYLIFKLSILTLIRFVFWMTIGFIIYFYYGIKKSTVGTGDDGEIELHVTSDPSTQPGTNTVTPPTAHSLSPATAQPVTVPTADFLASPTGTSRGEPTPNRPSTNNAPQQPAPANNKIYISSNPYNPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KG64</accession>
    <name>A0A8J5KG64_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Erbin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ERBIN-L</name>
        <name evidence="4" type="ORF">Hamer_G022950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014835">
        <property type="protein sequence ID" value="KAG7170200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="66"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="177" mass="20511" checksum="B3834454E8A4D949" modified="2022-05-25" version="1">MKPLLNRIVLSGCGLSTEQTRILDNLAKELRARMVTDFRAMDHIHRCCSEAKMKLQLHQIWCFYYKRPGLFNGCHMFLWGNFSDPYPSRKELETLIKAGGGIVLAREPNPESIPEKEQTVPFHSNVDDPLGNCSHYILYQEGNSEPQIKYDMAHIKSLPLIWLYSCIERFQLLPPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKM2</accession>
    <name>A0A8J5MKM2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposable element Tcb2 transposase-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Tcb2-L8</name>
        <name evidence="2" type="ORF">Hamer_G015064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKM2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035328111" evidence="1">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="104" mass="11888" checksum="69FAE26A3E8B70E7" modified="2022-05-25" version="1">MSVTLAGLSGGLLLTARSIIQWLEDCGVDYFKKWPGNSPDLNPIKHVWHIIRKELQDRGADSSEAKIEIQDIWDNIISPTREKLARCIQRLEKVIKLRGKYACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ML13</accession>
    <name>A0A8J5ML13_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042093">
        <property type="protein sequence ID" value="KAG7155301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ML13"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="132" mass="12697" checksum="BA44B921FDC461F2" modified="2022-05-25" version="1">MYGAVQWTVLRRRSSSGGGGGGGGGGGGGGSSSSSSGGGSSSGSGGSSSRGGGGSSSGGSCRIGVVSGSDGGRASGYSATEMGAKGGASGVGYVPRGKSKEGDDQVLCIYLGGYEEDVLRRKEEARRRRSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLN0</accession>
    <name>A0A8J5MLN0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-xylulose reductase-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DCXR-L2</name>
        <name evidence="5" type="ORF">Hamer_G023562</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040175">
        <property type="protein sequence ID" value="KAG7156068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLN0"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050038">
        <property type="term" value="F:L-xylulose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000214">
        <property type="entry name" value="L-xylulose reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051737">
        <property type="entry name" value="L-xylulose/Carbonyl_redctase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44252">
        <property type="entry name" value="D-ERYTHRULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44252:SF3">
        <property type="entry name" value="D-ERYTHRULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7156068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="243" mass="25528" checksum="39D68DDC764AC752" modified="2022-05-25" version="1">MGKFAGRRALVTGAGAGIGRALVIKLVEMGAEVFALSKTAANLESLKAECPGVKTICVDLSDWTKTREAVQKIIPIHLLVNNAAFASVGPFLTASPEVFDHMFSVNVKAVMNVSQVVTGDLVARKQRGTVVNVSSQAGQRALVDHAIYCPTKGALDMLTKVMALELGPKGIRVNAVAPTVVLTALGRIGWSDPAKAGPMLARIPQGRFAEVEDVVNAIVYLLSDESDMVNGHILPVDGGFLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMQ6</accession>
    <name>A0A8J5MMQ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Transposon Tf2-6 polyprotein-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Tf2-6-L4</name>
        <name evidence="1" type="ORF">Hamer_G009976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMQ6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="360" mass="40061" checksum="60F48A9FC339F0DD" modified="2022-05-25" version="1">MEKQLEKLTAFLMQQAEMAKQAQLESQPREERWSQILERVVSQQAPSHHSTTTTSGVAAASKWCATPGQVSPNQRAALVSVLDDKRIRILRYRVGVADDTELEAYLRGQGNVIVDWRDFYSRVQELGVYTNRVSVRPAPQVVVDATHPAGRDTVVRTPFSVAEATVMGFDIVKSLVIYQSILDPSASAGLLSAEDFPAQIQPVKQSKLTSDRSSLPPGVIRASSPTLLVVLPRPTYPVRSPHDVVASIGSGACLITTMESKMGYFQVKIEDEDQDFTCFITPWGRFKFKRAVMGIVSSGDEYNRHLRRRDEKMNQDIVDPQVVPNVLGEVRDVYVMRTSRASEPLCGMNERVHECCPLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNH7</accession>
    <name>A0A8J5MNH7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amyloid protein-binding protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">APPBP2-L</name>
        <name evidence="1" type="ORF">Hamer_G018836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036987">
        <property type="protein sequence ID" value="KAG7157760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNH7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042476">
        <property type="entry name" value="APPBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46575">
        <property type="entry name" value="AMYLOID PROTEIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46575:SF1">
        <property type="entry name" value="AMYLOID PROTEIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="526" mass="59757" checksum="6DBD83404B5F2459" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MP22</accession>
    <name>A0A8J5MP22_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neural-cadherin-like 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CadN-L23</name>
        <name evidence="6" type="ORF">Hamer_G024846</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034664">
        <property type="protein sequence ID" value="KAG7158558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MP22"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="4">
        <location>
            <begin position="169"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7158558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="371" mass="39071" checksum="F681D34149504DC3" modified="2022-05-25" version="1" fragment="single">MLGVTVQDVGVGTCAEAAHDTHEAARNTHRPAHTTQRNTHTTTHKTTHTTHQSAHQSTRCVGGCRAWAVLGDGFSVVDAKAWAVVGPRMGVETKCGCGNLPPPAYAHTCTPQTCLNGGRCLPTPTGTRCVCPHGTWGFRCKILMRHFEGSSEVVKDSRDAAASSVPRDHVVGGGNPVGGWAWVASIPACPEVHISLEILTTSENATLLYSGPDDLAPPPGTSSGEVVVLEVRGGRPYLLLDLGGGPVTLALTASYSLADSAWHRIDLIWKDELVEMIVDLCSGGSIDGPPTPPTRPAHNQSAPPIPPPPIPPDAHTCRGAARLPRAARVLNTPQPLQVGGLAHPPPAHTVYGWPEPPTARPLHGCVRNLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPI8</accession>
    <name>A0A8J5MPI8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPI8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="180" mass="19865" checksum="207E64E7F2439B74" modified="2022-05-25" version="1" fragment="single">VLRRWVWSSIHVLNIGSILSISASWNLVTFVAVSGIADPAIFLILLALLTIECTIEGAKPCMRPFTDVPSPCSCLFTISNFTSNVTATLDFLATLLGVLVAGCLGIARSHKTQLRDHTKHTPAYCRRTRAEGKNRFGLYEEKSTYPANKQVSALSILPLKISTELLCLVSDYEKMLFPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQ80</accession>
    <name>A0A8J5MQ80_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQ80"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="114" mass="9901" checksum="656041EC8C5970E2" modified="2022-05-25" version="1">MAECGSGGSGGGSGGSGGGSGGGGSRWWWCGGGGGGGGGGGGGGGGGGGGGGGGDGGGGGDRAELLVLYLQKEGREGTREGRGGCLTGDNVLTGAGEGGASGRGTGVVPIIENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRH1</accession>
    <name>A0A8J5MRH1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase GLYR1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G021300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031136">
        <property type="protein sequence ID" value="KAG7160642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRH1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="2">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="3">
        <location>
            <begin position="118"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7160642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="240" mass="25746" checksum="8057D65F3ABF8894" modified="2022-05-25" version="1">MMTPSDVIAAADITFSCVSDPQVAKNMVFGNCGVLQEISADKGYVEMTGIDADTSQDIAEAISSRGGRYLEAQVQGSKVQAEEGTLVILAAGDRSLFDDCQSCFQAMGKNSFYLGEVGNASKMNLVLQVMAGVTLAGLAEGMALADRAGLQQKDVMEIMELTSLACPLMIEKGKAIIEGGFPTHLPLQHMQKDLRLGMLMGDTLELPLPLTAATNEVFKHAKRLGYGEHDVSSVYIRTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTA9</accession>
    <name>A0A8J5MTA9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SmB-L2</name>
        <name evidence="13" type="ORF">Hamer_G025347</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027520">
        <property type="protein sequence ID" value="KAG7162621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTA9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="28"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="105"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7162621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="199" mass="21437" checksum="3641C7C75BAB4549" modified="2022-05-25" version="1" fragment="single">MRLVWVTIKRFKVQSTSGSTHFCIVTFSKNNKMLSHIGYRMKITMQDSRTFIGIFKAVDKHMNVILSDCEEFRCVRGKKTKEEKQEKRTMGLLLLRGETIVTMTLRPPPTEQDGPRVNLPGSSPGPGVGRPAGRGMPGTGGSGLQGPQMMQPAACGPQLNVSPRGGPPGGMPPHMMGGMPPHMGRGGPMAPPTGSIMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTX3</accession>
    <name>A0A8J5MTX3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of nonsense transcripts 3B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">UPF3B-L</name>
        <name evidence="5" type="ORF">Hamer_G020752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025502">
        <property type="protein sequence ID" value="KAG7164240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTX3"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000717">
        <property type="entry name" value="regulator of nonsense transcripts 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="44"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="518"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="608"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7164240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="656" mass="77607" checksum="BEB9F9D8D8E8F9B2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU71</accession>
    <name>A0A8J5MU71_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Hamer_G024863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025126">
        <property type="protein sequence ID" value="KAG7164555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="154" mass="16702" checksum="19A93C72612C7485" modified="2022-05-25" version="1">MAAADEYSTTSHVLQLCLALQDRLEKVEKEVQSLKGENLALKLVLEEKKTFASVVKDGEVEVDSWKVVAASATKCTLKRHSAVDLNNRFSTLSDECEEGASNTTSATPSVSVERGSSAVELLPTSLPYLPYHHPTTCFISSPLPLQRPSPSPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5MUD0_HOMAM</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Zimin A.V."/>
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                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="54" mass="6258" checksum="0391D5C64278A447" modified="2022-05-25" version="1">MMFQSLSSLNLLPLNLTVNMTLRSQRSQLTEIVTQILQAYQHNRKHLGKQNSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVB3</accession>
    <name>A0A8J5MVB3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Lytic polysaccharide mono-oxygenase, cellulose-degrading-containing protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G005089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035189015" evidence="1">
        <location>
            <begin position="18"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="490" mass="53847" checksum="A08ECA3383CA2A8C" modified="2022-05-25" version="1">MNPGLLLFVLAVGTVSAQQLISPPSRACRELGAMNSGVNDGTSVPKYSAGQTITVTAQVPNMKSGAFEFDLCPRADVQDEDCLFKYPLELAEGGGHQFKIESENPGGQYEVSLLLPQGVTCETCTIMVVNHKFRFSSQLTKACVELVDLILTQWTLITKQCAQDSSCSNQRTDLCADISITDENHLLKNTKDKILGQAGQRRSVIIFSISRLEKKNGTMAVLTNNDSDSKVQILEEICCLWRKTMISGIVLLGAHDKRASCRYEIVYKQEDFISLHSLFISGPEHNALEMNPGLLLFVLAVGTVSAQQLISPPSRACRELGAMNSGVNDGTSVPKYSAGQTIRVTAQVPNMKSGAFEFDLCPRADAQDEDCLFKYPLELAEGGGHQFKIESENPGGQYEVSLLLPQGLTCETCTIMVVNHKFRFSSQLNKACVELVDLILTQWTLITKQCAQDPSCSSNQRTDLCADISITEEKTRKTRFWGMIKKILFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWH8</accession>
    <name>A0A8J5MWH8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial genome maintenance exonuclease 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mgme1-L</name>
        <name evidence="2" type="ORF">Hamer_G013138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024020">
        <property type="protein sequence ID" value="KAG7165634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWH8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008297">
        <property type="term" value="F:single-stranded DNA exodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340:SF3">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="667" mass="75875" checksum="5455AAE44C8F737E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWZ6</accession>
    <name>A0A8J5MWZ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G010401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWZ6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061343">
        <property type="term" value="P:cell adhesion involved in heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007508">
        <property type="term" value="P:larval heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF21">
        <property type="entry name" value="PERICARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="80" mass="9220" checksum="7D131219769B5E6B" modified="2022-05-25" version="1">MGDFNQETLDWVNLTTHAKGEEFLYLIQDLFLTQHMSEPTRGDIILDLVLMTEEAMVDEVHTGKPNSGQQPLHTKMEYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY51</accession>
    <name>A0A8J5MY51_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Striated muscle preferentially expressed protein kinase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">speg-L</name>
        <name evidence="2" type="ORF">Hamer_G010123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY51"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="83"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="190" mass="21087" checksum="9C48299DA8315EA3" modified="2022-05-25" version="1">MKKPWMKFRKPSFSKRDHHHMLRREETVHELPSVRSSPSRPLVPTRQMTVSLINPYHSESDNHCVQHLEKPSSGCIPASPESPVRILSPLRNVTVCPGEPAEMVCVITGAGFWAESTTVTWAGPHGPLTDPRFEMEQHRDGTLRLHLGSCRVTDAGEYTCTITCAGHSIACSARINLAQGKDHSYSNGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY98</accession>
    <name>A0A8J5MY98_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Activating transcription factor 7-interacting protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ATF7IP-L2</name>
        <name evidence="2" type="ORF">Hamer_G018458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7168021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY98"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026085">
        <property type="entry name" value="ATF7-int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056565">
        <property type="entry name" value="Fn3_ATF7IP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23210">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 7 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23210:SF26">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 7-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16794">
        <property type="entry name" value="fn3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activating transcription factor 7-interacting protein Fn3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="130" mass="14612" checksum="F298CE90239E1BD9" modified="2022-05-25" version="1">MGKTEDHEAIASYQLYAYQEGAAPPSPNLWKKVGSVKALELPMACTLTQVWEVLWVFEVGDLSWVLTARKEVKVNPNIQVVHARTRLSLRGESSRHQKSSGAFLRTPKHQAGQEIDTWCKKPHPTTYAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZK8</accession>
    <name>A0A8J5MZK8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015125">
        <property type="protein sequence ID" value="KAG7169853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZK8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="215" mass="23960" checksum="96CBA5091AE05AD3" modified="2022-05-25" version="1">MLKEFKLVDVSSLDTPRTPASVNWEICVICQDRKSEPLICPAASKRHDGGAGYKSLADNLLAFNELGEVVGAKWHKSCRVRYDNLKLQRAQKRKESSGQEAGSGTSASSTKRTRSNTTCVDSMRNALCFFCHQDLGQQYHQIQTLGVGKHVRQAAELLENTALLAQLSEGDMVAREAKYHKRCLTFLYNRARAVSDTEKQETTYEMVVSSVVLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N159</accession>
    <name>A0A8J5N159_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hsc70-interacting protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ST13-L</name>
        <name evidence="10" type="ORF">Hamer_G013431</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Interacts with Hsc70 as well as DNAJ homologs and Hsp90.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N159"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14438">
        <property type="entry name" value="Hip_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000112">
        <property type="entry name" value="FAM10 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3420:FF:000001">
        <property type="entry name" value="Hsc70-interacting protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034649">
        <property type="entry name" value="Hip_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45883">
        <property type="entry name" value="HSC70-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45883:SF2">
        <property type="entry name" value="HSC70-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18253">
        <property type="entry name" value="HipN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="9">
        <location>
            <begin position="586"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="642"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00064040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7170616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="682" mass="75131" checksum="F87C466D405FD339" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N163</accession>
    <name>A0A8J5N163_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lachesin-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Lac-L7</name>
        <name evidence="6" type="ORF">Hamer_G013875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012946">
        <property type="protein sequence ID" value="KAG7171082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N163"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="75"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7171082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="211" mass="24695" checksum="51ACDE0E15479EE5" modified="2022-05-25" version="1">MESVAWVQVDTQTILTIHKQVITRNPRIALLHNDHRTWHLELKNVREKDRGWYMCQVNTDPMRYRQGYVDVVVPPDIIDRESSDDMTIREGQDVTLTCRAKGHPTPSIVWRREDNEDIVLDNEKTVPPVAWVPQQLEGAYIGQELTIECHTEAFPKSINYWTNTNGDMIVADERYEPIVTENSYKVYMKLRIRRVEPQDIGTFKCIAKNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1F8</accession>
    <name>A0A8J5N1F8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative CD80-like C2-set immunoglobulin domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G018556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012106">
        <property type="protein sequence ID" value="KAG7171441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1F8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF15">
        <property type="entry name" value="BEATEN PATH IIIA, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CD80-like immunoglobulin C2-set" evidence="3">
        <location>
            <begin position="63"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7171441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="223" mass="25790" checksum="1DE34DDF5B17F9B9" modified="2022-05-25" version="1" fragment="single">QVGSSTGEMVVLQDLELATSGTYRCEVITEAPLFITRFGQGNMTVIDLPESAPVLDGARTSYQLGERVVVNCTSLYSKPAATLQWYINDHLVTQANLLKRYKLQKERDGLETAVLGLTFVTARSHFPRGEMRLKCVAKIATVYFQSQETSVIETGYMLHTQPEERRHNENSYFFEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKTFDPLDVAEEDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1X6</accession>
    <name>A0A8J5N1X6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011989">
        <property type="protein sequence ID" value="KAG7171681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1X6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="146" mass="15657" checksum="7A7D99D6853DC0D4" modified="2022-05-25" version="1">MTEMVTFSSPPRLKNRKKKTPDLVMMAKIKVDVINSVMARFIARSSKKLLVSVVVVALIVGGQADVHSSSHFSSGGAHHGSSLSRSHDLMVGESPMALRLPDLMVGESPMALHLPDLMVGESPMALRLPDLMVGESLTAQPCPDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2M7</accession>
    <name>A0A8J5N2M7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen alpha-1(VI) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Col6a1-L</name>
        <name evidence="3" type="ORF">Hamer_G001086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2M7"/>
    <dbReference type="OrthoDB" id="6377893at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF4">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXIII) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035155189" evidence="2">
        <location>
            <begin position="21"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="308" mass="33320" checksum="E2C7E1A47FE3B91F" modified="2022-05-25" version="1">MLWVVVASVLLVVVPQRISSATSGTNNPDLSQLHKTPPPLEIRILDDALNSLKIPEARRLRHDYQRSSKDTQLDAEEVDEEDDDLVLGNFKTSPRFKRQYHPRQHSQFVNTRTQVHKQAIACPSVVPPSANISHWDHLKYVANAHVPGCVKSQCSHSCHRREPCAFDHETIMARLSLLEERLRGVTKIETRMKVHAALLLRVQTNPNFPGRRGDRGPQGPQGRKGMRGPLGSPGTPGSCTVSGSDSAPAGVEGPPGNKGYPGFIGDKLCGCNGDRGESGDPGKSQTGPPGPKGYKGAKGAKGPTPLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2S8</accession>
    <name>A0A8J5N2S8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Eif2b4-L</name>
        <name evidence="11" type="ORF">Hamer_G001077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2S8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="182"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="461"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7172084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="841" mass="90924" checksum="1FD4FA8A4581CD86" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3H8</accession>
    <name>A0A8J5N3H8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010657">
        <property type="protein sequence ID" value="KAG7172535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3H8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="98" mass="10989" checksum="A4DDE3C85E3CC070" modified="2022-05-25" version="1" fragment="single">MKRAKESGAVYRKKRKAREEVLNKNKGALFKYISRIETKSLSNSRDSSSTSSDSSTSTPSSDEEHEEENIPGPAVDRVDIKDVGLWPSKISNDTRIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4Y2</accession>
    <name>A0A8J5N4Y2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 26-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Tmem26-L</name>
        <name evidence="3" type="ORF">Hamer_G017911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010216">
        <property type="protein sequence ID" value="KAG7172928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4Y2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF8">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035156848" evidence="2">
        <location>
            <begin position="19"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="582" mass="66267" checksum="96769808440068DA" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5I7</accession>
    <name>A0A8J5N5I7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Transposable element Tc1 transposase-like 49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tc1a-L49</name>
        <name evidence="2" type="ORF">Hamer_G017996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009070">
        <property type="protein sequence ID" value="KAG7173707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5I7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="73"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="197" mass="23026" checksum="F6E51195C608EA60" modified="2022-05-25" version="1" fragment="single">ITSVTTNTTQQRLTTRGQIIALREEGLICHRRTTCCFDFNCEEVMSVCHSINGIPSYDTGDQKTLLCLFSERRPRPRLTTRDEDAAIREALHLDICAQTVRSHLHEAVIQNRVPAIKERLTYQHRNGRLQFAQQYVGEDLEFWSRVVFTDEKTFASTNHGKIHLWRPNRMRYNRAHIYEVARSGHVTLNMWGYISQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5N7</accession>
    <name>A0A8J5N5N7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Alcohol dehydrogenase transcription factor Myb/SANT-like-containing protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G031552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008597">
        <property type="protein sequence ID" value="KAG7173906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5N7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7173906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="90" mass="10748" checksum="994EDB704BB26ECA" modified="2022-05-25" version="1">MSVPPSATDLGNIHWSREETMVLIEHYRQHPCLWNVKVDMYRDRDKRAAALRQITEDMNRSGTTVTTSDVKRKIESLRNQHRRELRKMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5Z3</accession>
    <name>A0A8J5N5Z3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009370">
        <property type="protein sequence ID" value="KAG7173575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5Z3"/>
    <dbReference type="OrthoDB" id="6378520at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="357" mass="37956" checksum="2B45EA2DF2EFC3CE" modified="2022-05-25" version="1">MKSPGQAVATPKKAKKLAAETPELKKKAAKAQTPKVEVSQTQTPQTPKIKKGKAKNLDTPKVEVKTPKAEKVKTPQPQTPKVEKSETEPQAKKLKTPKTDTPAGNSSPEKIQTVVTEHSGGATRGQRGGGRGGFRGAMNGFRGRGGGFRGGRGSFRGGPGNFRGGRGGRGRGGRGRGGSVAEKNPCAVYMNFSSPIDGTAATEILKIGKAASAIHFGRNCFLTFGTEDEASTLIKKAAEIEFGGLKPFVDNAYKSSGQKEAEKRSSDGTTEPTPSKKMKVETSAKVETEKKDEEEKMEEGDGSEEEEDGAGEVEEEEGDDAVDEDDDAEEDDDAEEGDDKAEEEGSDEEEEEESDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6S2</accession>
    <name>A0A8J5N6S2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G032188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007854">
        <property type="protein sequence ID" value="KAG7174129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6S2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="328" mass="36908" checksum="EC91BB7A39110CD6" modified="2022-05-25" version="1">MNLVFLTLIWAEDPSTVKNMTTATQLYSKVKDMTTEKLVKRLIDKPDTVISASSVKSKVEKIFKVMCRESLVSLKYDSLNVSEEMKDNLEQTCRGVNILLKEVIGAFLITSNTYALCVGVKSCFSFPHKGVQDFYSALHIRDSLQGDRPNMSQGPRTIREVLQELHKDDPSSLTLTKYQNVLVHLTGILYVDGGGEVKEDKAEELVRLLHSSGMTDESQWEDLINDVKCDATLCKYVAKHIPHLVTGDIRVRDSSVSVYTTLLPLGRPDEITVRIDGDPDNIPHMVDLMKVVAACNNCEVNIHMNHHWKHPDTCSPSLDSALQDFFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N751</accession>
    <name>A0A8J5N751_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bric-a-brac 2-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bab2-L6</name>
        <name evidence="8" type="ORF">Hamer_G023043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006389">
        <property type="protein sequence ID" value="KAG7174905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N751"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016199">
        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008406">
        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035167">
        <property type="term" value="P:larval lymph gland hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007526">
        <property type="term" value="P:larval somatic muscle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045476">
        <property type="term" value="P:nurse cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007464">
        <property type="term" value="P:R3/R4 cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045467">
        <property type="term" value="P:R7 cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF111">
        <property type="entry name" value="LONGITUDINALS LACKING PROTEIN, ISOFORMS F_I_K_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="50"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7174905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="602" mass="64184" checksum="5FC60BE807C33C6A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7G5</accession>
    <name>A0A8J5N7G5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G015739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007499">
        <property type="protein sequence ID" value="KAG7174610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7G5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="104" mass="11255" checksum="2EFA5ADB1407CC75" modified="2022-05-25" version="1">MNLGTRLRILEELSGLLRGALLVPRAKQPGPCDASKRVGEPGPTFLYPTPSNPSWSCFTSSYKKRLLDPLVTFLLAPLGTKTVGVGRFYGSTQSHLAGLLLGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7K0</accession>
    <name>A0A8J5N7K0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WSCD family member-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G001209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WSCD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7K0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="2">
        <location>
            <begin position="74"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="245" mass="28169" checksum="2ED2A4621F018C0C" modified="2022-05-25" version="1">MKPPGTSTALVSFPGSGNTWVRYLLQQATGYYSGSVYKDYALMKNGFPAESVSNGSVVVVKTHEWGPEMRKTFGRAILVMRDPYLAIQAEFNRQSGGHIGHAQPDKYTRDGGRYWEKFVTNKALAWMNTTLDWLKFDRPLHLVFYEDLLDNLPEEMRRILEFLDLEVSDSNFDCMLRHQDGIYKRRRRPLNFDPFTPKLRKLVDKCKRLVDQAVREVLAGGDAKLVLHNLNYSNDSNGNQKSVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N837</accession>
    <name>A0A8J5N837_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neutral and basic amino acid transport protein rBAT-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Slc3a1-L1</name>
        <name evidence="2" type="ORF">Hamer_G003339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N837"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF225">
        <property type="entry name" value="MALTASE 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="1">
        <location>
            <begin position="118"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="397" mass="44385" checksum="E7D8665190DCBE02" modified="2022-05-25" version="1" fragment="single">QNLGIKAVRLNSIIEASDYLYSYTSITNYTAVDPLLGDSSHVELLAALLHQKGMYLLMDIPLSSLQTEVSDSSYGVSLAEVYPVLKYWLSLGVDGFFFPDITEYSDDPGLVEAMYKWRNVLDQFSSGSEHRVMMVPVALLEKLKSAEFTHLDHLLHLVDLIDVPVNLTGSAEMIPEVLKSATAWDSHASLPWINWNMGGIERERVAALTHHHPLGRSLLLLFFPGTITLYYGDELGLSQASQERGWSSIMHWNGGKHAGFSSVEPWQDLPEGWEDNNVEATNDTISSLTTMISARQKKVPIYINGIFDYQGDYHPIKSANYRVRHADHGLIIIDRFYPRRNQYAVVANLGPNTVNQDLSRFYFGGSVLASSHGQSGYVMFRNISLQPGEALACILDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8Z2</accession>
    <name>A0A8J5N8Z2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hormone-sensitive lipase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LIPE-L</name>
        <name evidence="4" type="ORF">Hamer_G020789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004696">
        <property type="protein sequence ID" value="KAG7175720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8Z2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010468">
        <property type="entry name" value="HSL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06350">
        <property type="entry name" value="HSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hormone-sensitive lipase N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="166"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="538"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7175720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="711" mass="77217" checksum="3DA886F8EE4357A5" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA54</accession>
    <name>A0A8J5NA54_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002849">
        <property type="protein sequence ID" value="KAG7176751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA54"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="329" mass="37348" checksum="C4B63F86CD8BEA0F" modified="2022-05-25" version="1" fragment="single">VKTRVPAALPTYTASRTPLAGNTLWSHNSLAGNTLWSHNPLAGNTLWSHNPLAGNTLWSRTPDKELINDMIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDALFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAESQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIGRLFVSFKKSSPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAL7</accession>
    <name>A0A8J5NAL7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Basic region leucine zipper-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G000257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAL7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="495"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="520"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7177036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="572" mass="63250" checksum="2A0C777AA3507AE2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBQ8</accession>
    <name>A0A8J5NBQ8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Chst11-L1</name>
        <name evidence="10" type="ORF">Hamer_G000296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBQ8"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7177070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="373" mass="43840" checksum="B5724AC8CE69C7C4" modified="2022-05-25" version="1">MFPRLAKFPRRIILTCVYMYCLLFIHRLNDVHEESKALKVAHLKTIHARAAQVEAGCASFPPSLTKLQQHANDAAKVSPNLAAHYTGLHLKAALKNIIYIKKHNISWCLVPKVASTSWAQALLALRGQLGNEYSDPPLQVVLREAFKMIDPTRVNQTINSSLKFLFVRHPFQRLVSAYRNKLEDSYTEQDGSYFYKNYGRSIVQKFRKSRKKITVATKLTPVGGKNQGDQNNDNEILDAENVMKTEEEEEYVEFKREPSFEEYVDYLINTDVESYDEHWKPIFLQCQVCDFHYDYIIKYENFKQEIDTFVEMLQETDRLPRRFILQWENRGGTDEKTTTEYLSQVSQHKVWLLYQKYRQDFLYFGYTMGNYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDR1</accession>
    <name>A0A8J5NDR1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcriptional repressor scratch 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Scratch homolog 1 zinc finger protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Scrt1-L2</name>
        <name evidence="15" type="ORF">Hamer_G016691</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002318">
        <property type="protein sequence ID" value="KAG7177403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDR1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055059">
        <property type="term" value="P:asymmetric neuroblast division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060562">
        <property type="term" value="P:epithelial tube morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000177">
        <property type="term" value="P:regulation of neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000043">
        <property type="entry name" value="Scratch family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000169">
        <property type="entry name" value="transcriptional repressor scratch 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000706">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000207">
        <property type="entry name" value="zinc finger protein SNAI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF38">
        <property type="entry name" value="PROTEIN SNAIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
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            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00064979"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00071743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7177403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="389" mass="42586" checksum="67FC2C7485E80BCC" modified="2022-05-25" version="1">MKLLPTGVYHELRAADPCFTCTFQYYPTTPDHAYAHVQPTTTTTFHQPCLPTSQSYLPTTRQQPTQSPCLRTGQQQACLGSSQQSCLSTSQQACLPASPQSCHQSSHQSSQQTSYPSSHTFTPLHLRPVEETEAAHDLLELARSAPAYTYQPPTPASSCDSLEAPSTSYSEATVCDGSEPLYEDSEASLITTPTPSPAGSSDAENVAPTCALGLDDGRSRVRVGRSEGVRLGRHKPRYTCSECGKHYATSSNLSRHKQTHRDLDSGNARRCHVCGKAYVSMPALAMHVLTHNLTHRCGVCGKAFSRPWLLQGHMRSHTGEKPFGCAHCGKSFADRSNLRAHMQTHSQLKNFRCKRCNKSFALKSYLNKHYESACYRDGACGEICTSPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NJ05</accession>
    <name>A0A8J5NJ05_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NJ05"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="193" mass="21693" checksum="8ED25405322E8262" modified="2022-05-25" version="1">MEYDKSLDDMEETNMTGTECEVARGENMDRMEEIVEVTCIMSPSRNKNGANKKDQNKPGKNELEINGSDDENQVKVKTDRGTNGDISKISGKKDRTKQNKNNENQSDLSGQVNSQTESGLECEKERKDDGKKMDPIGKDDSWWEKVEHVQSWTVRAVSGSKVMLSKRDGKEIAKKEANKGNNSTDEEGKRGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T3M9</accession>
    <name>A0A8J5T3M9_HOMAM</name>
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        <submittedName>
            <fullName evidence="7">Phenoloxidase-activating factor 2-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PPAF2-L8</name>
        <name evidence="7" type="ORF">Hamer_G020337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011048">
        <property type="protein sequence ID" value="KAG7172455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T3M9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF142">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035169940" evidence="5">
        <location>
            <begin position="20"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="638"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="549"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7172455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="893" mass="97325" checksum="333DABB010F8C939" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T6J6</accession>
    <name>A0A8J5T6J6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010179">
        <property type="protein sequence ID" value="KAG7172951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T6J6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="78" mass="9028" checksum="10E52F10A9A7914F" modified="2022-05-25" version="1">MQICALKRIEACKSGSINVEKRNYPRIVPLGSRRKWMAALENGRYVINWFEEATRSPKMYASHIDDNVGTDIANEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T8Q6</accession>
    <name>A0A8J5T8Q6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TRAF3-interacting protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Traf3ip1-L</name>
        <name evidence="4" type="ORF">Hamer_G017780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007950">
        <property type="protein sequence ID" value="KAG7174059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T8Q6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018799">
        <property type="entry name" value="TRAF3IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041476">
        <property type="entry name" value="TRAF3IP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31363">
        <property type="entry name" value="TRAF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31363:SF0">
        <property type="entry name" value="TRAF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17749">
        <property type="entry name" value="MIP-T3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAF3-interacting protein 1 C-terminal" evidence="3">
        <location>
            <begin position="239"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="320"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7174059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="405" mass="43719" checksum="46147343E885D827" modified="2022-05-25" version="1">MGQVKESGKENSPPHEIIDEGMIPNGHSPIEEVMESPPKLDSARPPSARPDGSEEPAEGIVEAIDEGIVTQEAPTDESEVPLPEPFADTLDDEGLHMPAEDGLVASTGPESLIQVDGGVEQETNEAEEPPVISHTPVGDNNDIDPAILKAMAPNNGLPHPEPPDSGVGSLDSPKHPPKEPESLPMAESLPMAPTPKPGPQPLRAMEQFGEGPAPTPPPLPLLPSQDDDGAAAAAAAVGEDGEGAGLLVAQILETKKELEDGRRKAFSPETPGHRRVPIEQSLLSDANRKKERELIQKDVQKLSGSIQSITRSVNPLAKMLDYLQEDLDSMQKELEMWRSENRQLSRTLKLEQSLTDQELEPLKSQLQEYETAVQDQRDKLSAIKSNILKNSDKISRLMAGINLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIL9</accession>
    <name>A0A8J5TIL9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7175979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIL9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="247" mass="27397" checksum="782B56CC7EA7F3FD" modified="2022-05-25" version="1" fragment="single">SREQFFEPSKKRGKSGSKCPSLVLFTHLREKRRMIHEQDKAIFSLYYLMGSDIVFEHGVSQLPFGGLIWCLLSDPADDNRITSSPPPPLPTMAEAVEVADGVVCNGPTTTKKKGPPLVPRDKFTRLAFPVETTEPEKALLKCVRCGQQGVPVWHHDCPRRPHPVIKDDDRSDTSSFCARSDSDNSSPRQASLAAIRNTHTLDAVRQALDECPEFIDAIIQKLTCRMTQVMNVSDPGKPTANKNVGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIM1</accession>
    <name>A0A8J5TIM1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006021">
        <property type="protein sequence ID" value="KAG7175471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIM1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="226" mass="24674" checksum="2A6A4152354B6536" modified="2022-05-25" version="1">MFNTSRCGGLQPRVTSTIPAVWRPTTSVTSTIPAVWRLTISVTSQYQQCGGLQPCVTSTIPAVWRPNHMLPPQYQQCGGLQPCVTSTIPAVWRPTTMCYLHNTSSVAAYNHVLPPQYQHGEAAYNHLLPPQYQQCGGLQPWVTSTHSSEAAYMCYLHTSSVAAYNHVLPPHIPAVGGLQPRVTSTIPGVAAYNHVLPPQYQQCGGLQPMLLHNTSSVAAYGQQKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKE5</accession>
    <name>A0A8J5TKE5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C-type lectin domain family 4 member M-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Clec4M-L</name>
        <name evidence="9" type="ORF">Hamer_G029175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003865">
        <property type="protein sequence ID" value="KAG7176190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKE5"/>
    <dbReference type="SMR" id="A0A8J5TKE5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF1">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 11 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035226607" evidence="7">
        <location>
            <begin position="21"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="8">
        <location>
            <begin position="158"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="106"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7176190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="281" mass="31519" checksum="BE49224F3149BB89" modified="2022-05-25" version="1">MAPLLLITLSLTLLLTPTTSLNTVDTVTPYIQPDGHEVRASLFVNQLAIMELVSQLKHGVGISTTSCQAVEENLVSILSTVNETSSIVLQLSQENTADSTSVREALAVVQQQQQQQQTDLHQLERVTSAMEGLQQQISQLQETTQPSLLTCPGEFFVLERQCLLVNREEKLKWVDARTWCRNKGGDLAIPQESRALISLLKSFKISDTFWMGASDLATEGVFLDVSSKPINLMSPLWKESDPNDYGGNEDCFFILDYSGVYNWYDARCTRHEYFICEHQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKL5</accession>
    <name>A0A8J5TKL5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Opsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Opn-L</name>
        <name evidence="17" type="ORF">Hamer_G009081</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKL5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7176295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="186" mass="21316" checksum="AA7776530D48825B" modified="2022-05-25" version="1" fragment="single">MFVFAYVLPLSVISCCYKLIFTSVARHNQQVIKENEMNSLNIQQRETQLARVVITTVGFWIMAWTPYAVVSLLGVFSWRGALTPVSTMLPAVFAKLSTVCNPFIYAVSHPRYRQELSHRLPWLCCRVEVLPRVVSSRQRPFTSNFSHTPSFRSSRKDKDLMDLPSPDDLAIFLEKKTVNRVTSTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLN9</accession>
    <name>A0A8J5TLN9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Band 7 protein-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Epb7-L4</name>
        <name evidence="2" type="ORF">Hamer_G018101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007025">
        <property type="protein sequence ID" value="KAG7174782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLN9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="96" mass="11060" checksum="A397531E130D27B1" modified="2022-05-25" version="1">MDMRSREGHVSTKEYMEAIRKLRGHSNAPACPRSRLPPLPPAPTPAYPLSVRPWPKADEKNEELRYLQTLNTISAEKNSTIIFPVPIDIIHHYMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLT1</accession>
    <name>A0A8J5TLT1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G023319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006456">
        <property type="protein sequence ID" value="KAG7174887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLT1"/>
    <dbReference type="OrthoDB" id="6370449at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7174887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33418" checksum="32F4A2873C4F11C2" modified="2022-05-25" version="1">MSIPKKRHYNGHQDTMVEASHRTSPDIMDVTYDEVSYDSYLSGVLNDFGIQFSPGRSSIVEIPEDDFEPLSKDENVSSPGGAPSPSDLDPSDLNREQFSSGSGATFLPLEYNGQFEESQAPSQSSVSSAGKKLRQKKPKVYDSLPFEDEEMERKRLNAITAKKNRDTKKMYMRTLEQTLKSMKTINKQCHKALKKTGTDVGMLHQKIRHLEETLERSTSQIRENNMEIRRKRERMNLLMAHLDIIISGFDDHNPAKRIITTLLKTFQTEDSSDEFQKEDSSYTSSRENSWYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TMR8</accession>
    <name>A0A8J5TMR8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G008327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TMR8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="82" mass="9372" checksum="EC7F5106E4F0438B" modified="2022-05-25" version="1">MTPPAELCDGWPLDPQTTLQGLCWVRKFLVKAQTWPAAAWAEAPCRLRTVMATTPKKSAIRNRINKNTWSKMMSAVGIMWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TNC3</accession>
    <name>A0A8J5TNC3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G009856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TNC3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="260" mass="29835" checksum="199FD038780B5454" modified="2022-05-25" version="1" fragment="single">DVRQTAVRAIEGVTPLHRSSVSVGTVNSRDLVDVPRHNAHVIILTKYFPPPSPQITQRIRESHLYSADCTPVKMTTMDEYFDRITEASLDNNSEFITVFSQKDWQLELHEPNYAPVTQMMSTLSIDRNLTRPSQAPDIPTTTFNLVSSSTHSYTAQTPQRHGNNIFQDQTQQGHWNSYQAQTQQGHGNNIYQDQTQQGHWNDMNQQQQMTRQEPGMTMNPAAHLEPEGSRQGRGHRRPRGDRLDLVARDDDHCWVSRNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J5S3</accession>
    <name>A0A8J5J5S3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Casein kinase II subunit alpha</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Csnk2a-L2</name>
        <name evidence="16" type="ORF">Hamer_G010612</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J5S3"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035314964" description="Casein kinase II subunit alpha" evidence="14">
        <location>
            <begin position="20"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="73"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7153316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="384" mass="45305" checksum="B60B3AEF7D34E79D" modified="2022-05-25" version="1">MCTVNLLIFACLVPLDVISQTELAGFGRTVYRGLHKMPLASRARVYADVNAHRPHEYWDYESHVIEWGQQDDYQLVRKLGRGKYSEVFEAVNINNNEKCVVKILKPVKKKKIKREIKILENLRGGTNIITLQAVVKDPVSRTPALVFEHVNNTDFKQLYQTLNDFDIRYYLYELIKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEELYEYVEKYQIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQERLTAHEAMEHPYFYPIVKEQGRHMSSPTPAPPALTGVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JD13</accession>
    <name>A0A8J5JD13_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine/arginine-rich splicing factor SR45-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SR45-L1</name>
        <name evidence="2" type="ORF">Hamer_G024561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041787">
        <property type="protein sequence ID" value="KAG7155386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JD13"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="238" mass="27453" checksum="406C8AF8931A9F93" modified="2022-05-25" version="1" fragment="single">APWINDVVPTSDDDDKNTEATTPNTSRNARRPYFYDSANGVEEDCDGDTDSSPWSQAPVRRWSKSPRQRRGRDRWAPWRGASPKSSPRGSKRHQARYSPRFSPNGARRYYDQSYHGRVAPQYDPYFYQQRGSGVGPHRTAPRWARQNQYEQTTQGRPRQYRGPRPYRSPAAHEEPPQVEEQQPKTPTGDKIHPSLPRTPYWSPEGPEGPKRHTLSPGAKDNVFSPVTPKRRSARWNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JD50</accession>
    <name>A0A8J5JD50_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039425">
        <property type="protein sequence ID" value="KAG7156207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JD50"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="106" mass="11352" checksum="B074F179A99ACFEF" modified="2022-05-25" version="1">MRSRPLSVSQAGGHLPSRPYYLLLTPPDTIPSGYTNSLQKEQQKDTLPHKSSATSSTVPPPPTAPPPPTAPPPQQRHHLNSATTSTVPPPQQRHHLNSATTSTVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDG6</accession>
    <name>A0A8J5JDG6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cysteine-rich with EGF-like domain protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">creld2-L</name>
        <name evidence="12" type="ORF">Hamer_G015053</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRELD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDG6"/>
    <dbReference type="OrthoDB" id="19903at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039">
        <property type="entry name" value="FIBRILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039:SF38">
        <property type="entry name" value="KUNITZ_BOVINE PANCREATIC TRYPSIN INHIBITOR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035264382" evidence="10">
        <location>
            <begin position="23"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="172"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7154691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="403" mass="44111" checksum="E14784AAD0AB140C" modified="2022-05-25" version="1">MQSQCRKEILLLLVVGLSCLVAQVIPDTSKSKEGSPGSSNDGDKSKNNNSKENLKSAKLPPCASCKTLTESFKKGIESTARGKFEGGDSAWEEEKMMSYKKSEVRLIEIQEKLCRDVERGQKQCEAGAEEHEGLLEDWWFREQETQPDLHTWLCIDTLRVCCPTNHYGPRCLPCKGGIENPCGGNGKCKGAGTRKGSGDCSCNPGYKGDMCDACTYGYYEAYKDDTKLLCEQCHKACNGPCSGPGQKSCAACKEGWLMDTEKGCLDINECAVDKTPCKRNQFCINNEGSYSCLECDKACDGCSGDGPDMCDKCAEGYKLDKDLCVDNSAQERDKHMTFARYVTYAGLTLATCIILQKNTIIAAIVGVSVAVYISFSEYYLKDTPAPPVTPQLPSSLFSQDIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JF30</accession>
    <name>A0A8J5JF30_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replicase polyprotein 1ab-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rep-L3</name>
        <name evidence="2" type="ORF">Hamer_G030518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042589">
        <property type="protein sequence ID" value="KAG7155208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JF30"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="331" mass="36385" checksum="2A5A5FB6D61CDBD9" modified="2022-05-25" version="1" fragment="single">EVVTDSDAPQEVVTDSDTPQEVVTDSDTPQEVVTDSDTPMEVITDSDTPMEVLSDGYTSQEVVTDSDTPQEVVTDSDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPLEVVTEADTPLGEDISLRWSLRTLPREVVTEEDTLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPLEVVTDSDTPQEVVTEEDTPQEVVTDSDTPQEVVTDSDTPQEVVTEEDTPLEVVTNSDTLQEVVTDSDTPMEVITDSDTPQEVVTDSDTPLEVVTEEDTPLEMVTEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFX9</accession>
    <name>A0A8J5JFX9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 22 member 6-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Slc22a6-L1</name>
        <name evidence="7" type="ORF">Hamer_G005872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFX9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7157437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="121" mass="13578" checksum="74C9C9DDFB25D809" modified="2022-05-25" version="1" fragment="single">DSCTYTVDRSSLAGLEEKHCTEWDFDTSVFTRTLTSEFGLVCQNSFLRPTFQSIYLFSTVFSSIITGYLADRYGRKIVVVVTLVVYSLVSLSISAVTNFNAILALRFIMGLLTNHCSYLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JG03</accession>
    <name>A0A8J5JG03_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041133">
        <property type="protein sequence ID" value="KAG7155568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JG03"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="243" mass="26831" checksum="3FD5E8FCF6621367" modified="2022-05-25" version="1">MEGPPAKMRRPNFSEAEVYALVTEVAKRKEMILGKSSLYTRIPGDVESEEPINEEEREPTPGPSGARFTATGSCFREEFMFRPVQEKDDSITLILNEDIQEHDITVPIVHLEPETSAPTNIPGISSSGTYEVETCSSSNTRQPIAATTEQRSRSSTPSATAVRSTVTGDSTDEMGSSPMPSTIRSGRRPRTSSARKDEDLLREMLRVQTQMRDSFLQLVANTECIASAMLCIARVMQSKNPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGU9</accession>
    <name>A0A8J5JGU9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc metalloproteinase nas-13-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">nas-13-L1</name>
        <name evidence="16" type="ORF">Hamer_G015860</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038275">
        <property type="protein sequence ID" value="KAG7156931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGU9"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 12" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035319437" evidence="13">
        <location>
            <begin position="23"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="15">
        <location>
            <begin position="100"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="14">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="14">
        <location>
            <begin position="347"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="14">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="347"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7156931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="445" mass="49802" checksum="BC246026E9E41F4B" modified="2022-05-25" version="1">MKYWWSVLLFLGLSVTSRLTWGQTILPDVIIGDPNDPSNDIIGEPISKEEEKASLSKVTEKLGPKEDPITRSGFFQGDIMIRSKDELYQIIEGDPLGQMSAVKNPQRTWPDADIPYVISSSFTSQERSTIARAIAEYHQRTCITFVPRTTHSDYVHILKGQGCSSAVGRSGGVQVVSLGNGCVYLGVIMHELMHAAGFWHEQSRFDRDDYVTIHWNNIQPQLTYNFDKKSSSVTTDLGLSYDYGSIMHYGPHAFAKDYRYPTIEPKQNGVTIGQRDGFSELDVKGLNLLYKCSGTGPTPKPTPEPEDCVNKNQYCAYWAASGFCFTNNAYMKINCKKSCNFCGTSDCEDQNRYCSSWAKNGQCQQNPKYMSLFCKKSCNLCGAASSSCVDHNSYCQDWSRRQECKRNQAYMSLYCSKSCGSCKDSPANEVADDHIPAIKPPYSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHZ2</accession>
    <name>A0A8J5JHZ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DDE superfamily endonuclease domain-containing protein 63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G006138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHZ2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="138"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="296" mass="33746" checksum="A8AA1A3EA9247DCA" modified="2022-05-25" version="1" fragment="single">MPRRRYRRVSDEDRDRIITRYEAGEAFLDTAAELRTPRSTAYEIIRKFVETGEIRGRHGGGRPPVLGDEAKDFLVMLVEATPTITIRELNHTLRALDGELITLKQVHNVSANRNSEDVKAARIAFAQYMYEDGIHQHRVYLDETGYNLYTCRTYGRAPQGQRVNRIVAGQRGSNLTLIAAISNLVGLFYYEIHVTSVTKEVFKNFMTSLDSVLGPEAALILMDNAPWHAGIEQEFEDRVIKKLPPHSPFLNPIENCFSVLKATVKRQLNNIADRCDARAARRHGVTCSMYRERLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ26</accession>
    <name>A0A8J5JJ26_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G008762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJ26"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="420" mass="46813" checksum="04067AF310486BA2" modified="2022-05-25" version="1" fragment="single">KTTVKFSQVNEVESRSVNDEVRLLEWQIKLREAEAIAKEADSEKLRLRIQLCQTIDGLTPRSSFSHFDPARAARLMPTFSEETVDEFFIAFERLATTLKWPIEFWPICSAGVCRLMPFVPGAYRQGFRGLRKKAEQTPPLNLSSKREVFSKWLHSKEVQRTSNPSLHRARQGNTNNSNFVHDRRSWTRLPPNGASKFSTNPVESQVIRQSFAEQGCSWNTGKPAMIITEETNTSPVGVMAGLSKADSMPIGLISTKGEFCEWPRRWYLSSLLSQGTVEVDGVETPVTILRDSGCLQTHQRGLRARAACCWSGSHTGNDLAGGQMGNVTPPPVLRKSRVYRSELQQLLKIICPKDVLLTRQLLPQDISSAVNAVTESCFNSCARARRFITALVSDSANNCAIPTRCFSQDGVLLAPLAPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJC0</accession>
    <name>A0A8J5JJC0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <ecNumber evidence="4">4.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PCK2-L1</name>
        <name evidence="16" type="ORF">Hamer_G008960</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJC0"/>
    <dbReference type="OrthoDB" id="5841594at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046327">
        <property type="term" value="P:glycerol biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019543">
        <property type="term" value="P:propionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.20:FF:000005">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [GTP], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000003">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase, cytosolic [GTP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003253">
        <property type="entry name" value="PRK04210.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal" evidence="15">
        <location>
            <begin position="61"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase C-terminal P-loop" evidence="14">
        <location>
            <begin position="292"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7158311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="657" mass="73141" checksum="EF0663AC55FAF038" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJR3</accession>
    <name>A0A8J5JJR3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G006357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJR3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="325" mass="35332" checksum="F45E44E9BA648B39" modified="2022-05-25" version="1">MSREFIVSPTASPNYVLPLPLETDICDAGVGMVILLPPKGLLTPPLLTSPLLTPYPGVLTPPPGLLTPPPGLLTNPKGLLTPPPGLLTPPPGLLIPPPGLITPPIGLLTPPPSIFTPPPSILTPHPSILTPPPSILTPPPSILTSPPSILTHPPSTLTASSKYIHISSKYTHTSSKYTHTSSKYTHTSSKYTHTSSMYNHISSKYNHISSMYTHIFSKYTHTSMYTHTSSMYNHTFKYAHTSCTYTHTSFMYTHTSSMYTQTSTVQQREIEKVFVLRPKGHQPGKKTSYLSFVTTSETKPGSALAKKGTDATKDRQLKLITSCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKT2</accession>
    <name>A0A8J5JKT2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Hamer_G021954</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043253">
        <property type="protein sequence ID" value="KAG7154944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKT2"/>
    <dbReference type="OrthoDB" id="6375364at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF55">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 75-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="44"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7154944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="351" mass="38734" checksum="9D22A4BA51FDEF26" modified="2022-05-25" version="1">MTNCSEGGNCDNCSDVLRGDSTPAPLLLFGVFHCYVVFILGTVCNVVAVWCVVTCNKIHPPVKLVLSSVFVTTFLMCLVVMPFAAQVSLSKLLCEPSRIPLAVSMSFGLLYTTLAEMELFYISAVAFLRAVAVWSPHRRSIGMKMAVGIVVSVFLYSITTTLGLLGPIWMRFVKEKSTAGMVVGLVYTFLHTLLPVLLTMACYCSMMLAVCRNKRRLAAHSQHSTNSVRVIDEATRAMMAVFVTNLLLALPHSVFHLFYDLPFTTYVIIHVLFFSHFLVDPMVFIWFNGGHRQRVWGKVLVGLERVRCWYSSSTAASISTSTSTLATVGTPASSTDDAKNHNQIHARSQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JM50</accession>
    <name>A0A8J5JM50_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Ryanodine receptor-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RyR-L3</name>
        <name evidence="17" type="ORF">Hamer_G014919</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035946">
        <property type="protein sequence ID" value="KAG7158035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JN47</accession>
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        <name evidence="3" type="primary">PGBD4-L14</name>
        <name evidence="3" type="ORF">Hamer_G014041</name>
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    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
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            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="923"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="974" mass="108666" checksum="5816A98B0A70076D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNE6</accession>
    <name>A0A8J5JNE6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pro-resilin-like 116</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G019678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029207">
        <property type="protein sequence ID" value="KAG7161487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNE6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035309148" evidence="3">
        <location>
            <begin position="20"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7161487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="92" mass="10123" checksum="6534E4AA698B95FC" modified="2022-05-25" version="1" fragment="single">LPQVLLLTATLAVLSCVLAVPQLRDPQANVPRYEFGYEVNAPDYGNDFAHAERRDGSDTSGQYRVLLPDGRMQIVSYTVNGDSGYVAQVSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNM2</accession>
    <name>A0A8J5JNM2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G019441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035076">
        <property type="protein sequence ID" value="KAG7158429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNM2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="351" mass="38190" checksum="8DE14BE46EF1D583" modified="2022-05-25" version="1">MVTSVVVWVGVVVWAGVVICGAVTVSPISLSSLPVAVHTFSSTNDGENVDGRRRGRRYLPIRLLGRPPSTTQTPVMFAQASDSQYQYMPVKDDGTIYELDPCPAPSPPSGGGGGSNVFSLLTFSIVTANVLINAVSNVNNNNNRNNNNNENNNNGNINNENVSNNLDTNNNDNTIMTGRALGNTTSSCVCRGQRRRRGAIENIPKEARKTGEMTSKETPHRNRSDRSIPTVEKPRKTPTEGLNLTIEAPNKHITHGSTTHEREAAWAKQWAVWVKVCVPWVVCETSRAAPHTTGLASFTTRFSGLASGLLGLRHIPTQLLEEARARGARGESCTQVFPCPPLARDFEMFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNY4</accession>
    <name>A0A8J5JNY4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small glutamine-rich tetratricopeptide repeat-containing protein alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SGTA-L</name>
        <name evidence="7" type="ORF">Hamer_G019926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028706">
        <property type="protein sequence ID" value="KAG7161912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNY4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032374">
        <property type="entry name" value="SGTA_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16546">
        <property type="entry name" value="SGTA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="SGTA homodimerisation" evidence="6">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7161912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="282" mass="30686" checksum="4E5743F2F6C72E07" modified="2022-05-25" version="1" fragment="single">MEKEVVNRLVYSMIQFLQSQLERGAGGGGLTEEGVESVEVAVQCLETAYGVSLSQSDLAVSKSLYQIFSDATIGEPIPESVTRSAAQKMETTPKEATPEEKAEAEQLKNEGNQLMRDDKFTEALDCYTKAISKDCLNAVYYCNRAAAHSKLNNHREAIEDCRRALEIEPQYSKAYGRMGLAYSSLNDQYQAKDCYKKALELEPDNESYRGNLAIAEEKIQSDPQQSRPNSIGGFGTAGGLPFGLGNLAGLGGPGGPDLTSMLNNPALMNMATQLMSDPNMQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ05</accession>
    <name>A0A8J5JQ05_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G006338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQ05"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="657"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="778" mass="85593" checksum="50EECDC163C4E5E9" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTE7</accession>
    <name>A0A8J5JTE7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPN-loop GTPase</fullName>
            <ecNumber evidence="9">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GPN1-L</name>
        <name evidence="11" type="ORF">Hamer_G019111</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010026149">
        <property type="protein sequence ID" value="KAG7163842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTE7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000888">
        <property type="entry name" value="GPN-loop GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7163842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="389" mass="43768" checksum="20DE55D93A9217AF" modified="2022-05-25" version="1" fragment="single">ETKRYKMETKTVEPTVMDVTGDSQLPGDSSEGASSDGAQTSSSSGARQRSYSPPGAPKKKEPMCIIVLGMAGSGKTTFVKRLDSHLNIRKPHHVINLDPAVDKLPYISYIDIRDTVNYKEVMKQYGLGPNGGIVTSLNLFSTMFDDVLKLIAKKEEELDYVIFDTPGQIEVFNWSASGPIIAGALAATYPTIIVYVLDSVRSTNPQTFMSNMLYACSILYKYKLPFIIAMNKIDIVDCKYAMNWLQDFDEFQDALSSESTYASNLTRSLSLALEEFYSTIKACGGMDAFMHLTDEAAIEFEDYRSEHEMLKMKKKSREEEREKGAGLEHKQLLKDTEIYLTHGSDSEGEGEVLDEEDTMEKKELESFQQFLSNQKAKREHQRYNVLPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTH6</accession>
    <name>A0A8J5JTH6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G014502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026055">
        <property type="protein sequence ID" value="KAG7164027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTH6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="216" mass="23906" checksum="B829BA7C469BF8CA" modified="2022-05-25" version="1">MGRGGGRREEVEEERRENGRLEGVALGLVFAGWPGGCAMPGGSLVLAEFPHEQRIGYAHTTPGVRPHYTQSTPTQHAIRLTPTSRQTLIRKHTHTFTGFPVRRATGQHLTCDGVEEQGHRHLYSPLSTVTPAHHPVMPKSQDHATRRGGAGRGWHCVEDLEVALEYEVPTQEGHDVPQQCQHRRAMGVYSNSANTEGHDAAPLTVPTHRRTMVLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUG1</accession>
    <name>A0A8J5JUG1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vigilin-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">vgl-L6</name>
        <name evidence="4" type="ORF">Hamer_G003636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUG1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="40"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="119"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7164431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="194" mass="21914" checksum="B5E6715DAF67D496" modified="2022-05-25" version="1">MSSRVNNNLRERRQVMKVNQERSRPLPPWMSRMRAQWVEETVSETVKADNCLFGVIIGPGGSTMKELQVKYNIRVLVPRKGSKDEPIIVEGKDKTLVKDAVLRIKALIAEEKERRRVTTPVSQTLCIPKALHGKVIGLKGQNIRPVTQALKIKIKFPNKNDNSDEVTLTGLPDQVDQGISRLLNLVTRFPPCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUQ0</accession>
    <name>A0A8J5JUQ0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch-like protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Klhl5-L</name>
        <name evidence="4" type="ORF">Hamer_G022258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027013">
        <property type="protein sequence ID" value="KAG7162806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUQ0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000017">
        <property type="entry name" value="kelch-like protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000021">
        <property type="entry name" value="kelch-like protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF17">
        <property type="entry name" value="KELCH-LIKE PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BACK" evidence="3">
        <location>
            <begin position="41"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7162806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="477" mass="52599" checksum="5DBDCD458A773A75" modified="2022-05-25" version="1" fragment="single">TLELHEDTVEVVLSTAHHLLLTEVVDVCCDFLTKQLHPANCLGIQLFADTQGCSDLHRLASTYTAEHFQEVMQHQEFVQLPTEEAARLLASEDLNVPSEELIFQALVVWLKHDLETRTKDMARLLGLVKLPLLSPQFLTDHIETNSLFKEDRECQELILEALKYHLLPERRSTLQSPRTKPRKSTVGDLYVVGGMDSNKGSTGIEKYNLRTNSWTTVGTMTGRRLQFGVAVLDGKLHVVGGRDGLKTLNTVESYEPSTRTWSQLPPMSTHRHGLGVGVLEGPLYAVGGHDGWSYLNTVERWDPQARQWSYVAPMSTSRSTVGVAVLNGRLYAVGGRDGSSCLRTVECYDPHTNKWTPCAPMARRRGGVGVGVVNGFLYAVGGHDAPASNPCASRFDCVERYDPATDTWTQVACLNVGCDSAGVSLLGDRLFCVGGYDGQTYLNLVHAYDPQTNEWMQMSPLATGRAGACVVVVKKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUX0</accession>
    <name>A0A8J5JUX0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Tigger transposable element-derived protein 1-like 223</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TIGD1-L223</name>
        <name evidence="1" type="ORF">Hamer_G003718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUX0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="109" mass="12509" checksum="EF22D2B898E9A021" modified="2022-05-25" version="1">MISTEVHIFFHTNRTYNDFAVNKDILSLAGQAGFDELESEDIEDVLASHTEELANEDLQLLTEHSPVEDDDEEEIAQRMLTTKKMAEAFNMIQHGMQILIDDDPNRERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV65</accession>
    <name>A0A8J5JV65_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Supervillin-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Svil-L1</name>
        <name evidence="3" type="ORF">Hamer_G007382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JV65"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="552" mass="62105" checksum="52D3DCD9AA935D62" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW21</accession>
    <name>A0A8J5JW21_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G016465</name>
        <name evidence="2" type="ORF">Hamer_G027724</name>
        <name evidence="1" type="ORF">Hamer_G028159</name>
        <name evidence="4" type="ORF">Hamer_G028582</name>
        <name evidence="6" type="ORF">Hamer_G029669</name>
        <name evidence="3" type="ORF">Hamer_G031567</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031703">
        <property type="protein sequence ID" value="KAG7160051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010024424">
        <property type="protein sequence ID" value="KAG7165255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010020298">
        <property type="protein sequence ID" value="KAG7168261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010015251">
        <property type="protein sequence ID" value="KAG7169837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010001948">
        <property type="protein sequence ID" value="KAG7177510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW21"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7168261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7169837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7174560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7177510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="186" mass="21412" checksum="E6C1C0D6EE0F4E2E" modified="2022-05-25" version="1">MDFRLVRILRDTDVQEILSGTPRRLGTHIRFANHYQILQDGPLAEGEGVLLGYDLPEDGVHCVSLYRCLDGRYLYHDSTPRPMHHLVRRFMQIHNIPQEQVTIVDAIVQGPVFHTCAYHALAFLDIVSSVVIEDSWLVVHHYKEAIRSFFPDELVVLRVFRMIGEFHNTINLTATSIYDSVLPPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXQ8</accession>
    <name>A0A8J5JXQ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G004439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXQ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="94" mass="10734" checksum="E6E1ACBC8160CA1B" modified="2022-05-25" version="1" fragment="single">RYEGPGELILIDGNLNLEEWINILEASLLPSVRAYSIPEPLPIRLAQNRFPIHSSQAIANRPEIRVNRLPPPTLNPTENFWGLMKKQKRIPDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JY16</accession>
    <name>A0A8J5JY16_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane emp24 domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Tmed1-L</name>
        <name evidence="12" type="ORF">Hamer_G002303</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JY16"/>
    <dbReference type="OrthoDB" id="5976732at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035310710" evidence="10">
        <location>
            <begin position="23"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="38"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7163213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="239" mass="27256" checksum="DDEBA0BE988B1E9C" modified="2022-05-25" version="1">MASHSQIYLVLLTMFLVHTSYSREIEREMTVEVKAGTEECFYEMVKAGETLDVEYQVIDGGQGELDINFYVAGPLGTVLVQDLRRGEGSHRTTMSEQGDYRICWDNTFSHFNTKTVFFGVMIENENDDDDDDLWDSGFEASVTAEDIYEMKIEDIKGAMDRIRGHLTKSRFMQDQLRAYEARDRNVAENNCSKVNTWSIVNVVIMLVTGIIQVVLLKSLFDDKSRLHGIWKKGAASTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0N7</accession>
    <name>A0A8J5K0N7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Hamer_G012917</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0N7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7167457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="278" mass="31821" checksum="3F180DE9B04CEDA3" modified="2022-05-25" version="1" fragment="single">MMCRGTGAGYDGRRGVMWRGTGAGYDGRRGVMWRGTGVMWPGGLVLEDTCKENTCLGNTITPVWINLCWGRCVRRQVVLVQVGLLALFVFLAQLIRPDQSSFGPSSSGPKERSEELRRRVKEICSVFNVSSEISPLQLNIHLKTQEYMLIQPKFEDVWPDMLASYRKFLFIRHPFHRVVSAYRDKMEVITEVEDLGISHFMKKKISEKFGSSSTDPEGVVKFEEFWLEVEEEMGQFPVPMKTTAASSLASTYLHKLNSTLRRAFVSRYILDYLSFNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1K0</accession>
    <name>A0A8J5K1K0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Embryonic gonad-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">eg-L2</name>
        <name evidence="11" type="ORF">Hamer_G004475</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1K0"/>
    <dbReference type="OrthoDB" id="6352325at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="370"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7163344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="435" mass="48190" checksum="7EC60A146E1ECE53" modified="2022-05-25" version="1">MSQLCKVCGEPAAGFHFGAFTCEGCKSFFGRTYNNLSSLNECKNSGRCVINKKTRTSCKSCRLRKCLMVGMSKSGSRYGRRSNWFKIHYLMQGNTTTSSASVTATTSSSSDMIFTSEQSTTTTASNPTSPSLLSPSPDGKTLSPDFRDFKDFKLSPDFKLSPEFKIGSDFKSSFECKGLNSPTPSSSESHNSDSSLELNEKSLFPPYPEHLYPKELLALYNLPTLTPHLPPYVAPTSLAHRYLYPYYPSLLSVYSRRQYLDSLLQKARQNEASTPPVEVEDEPRDLAASPNREFPPPPKFFKPNSTRPHPDLRVAVRNTSNRSPVRGILPLRQELPVLDIPPGYNPGHDLTPRGSPEIVPIAATAPQDLPIDLSVKNKSPSPPRLVSDDERSASNSPHGTDDEEREEKEEEDEDEGRKSKEEQEAPLDLSAARTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2R8</accession>
    <name>A0A8J5K2R8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020459">
        <property type="protein sequence ID" value="KAG7168136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2R8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="73" mass="8303" checksum="9029EB5C2AA6CFBC" modified="2022-05-25" version="1" fragment="single">MGKGRDLLDHLHHHHTEPQRVKLRTGSTSSVNSTSSDTNTPSSHKTKKQKKSDRKHHHLLLTNSLLSYLSVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3H2</accession>
    <name>A0A8J5K3H2_HOMAM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G011211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Homarus</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3H2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="90" mass="10045" checksum="AC9966E439664C2F" modified="2022-05-25" version="1">MGNHEWSQTLEVISAVLECLADRVHTAIQTRPISTTPSSLAACWTCLASFYVSRGMVTISILIGRHENSRVIFLSRDWSRYGHLGQRPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K546</accession>
    <name>A0A8J5K546_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zonadhesin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Pleocyemata</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7167215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43690" checksum="E3A76A12C63B3603" modified="2022-05-25" version="1">MWRLTATLLVAALASATPQGGYLPPRPDPVCPPVTSVVYDTRVQTSVYVQTVNQVNTQYITTTQVRQQVVPTTFYQTRVVTQVRYQTSVVQQTSVLYIDRVVTQTVPSPPIQQTIYVTSTRVVPQVSYVTRTQVQTQVVPVEVTRTQIQTIYQPVVSYFTQVVQQTRVVSIPGPDIVQTRYQTQYQTSVVRRQGPGNTRYVTSTQYRQQVQTSYVRGQNVYSTSYVQRQQVIPYTSVNTRYQTTYVTREQVVTRTNVVTQTQVQTQVVPQEVVRTQVVPTTIYTTRYETRVQPFTQVQTVVQTRYVTPAPVVKTQQQVQTSVVQVPGQNRVITKQVVRTQQQQQVVYQTVNQPRQVTVTQTITATCGKTGYNYNTPATPFNYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K586</accession>
    <name>A0A8J5K586_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="214" mass="24666" checksum="0B8E39CFE2B6F3D5" modified="2022-05-25" version="1">MDNPDDVGNSRSRRGTSHHWSQPCDKIAHDETNTVESLSTNILTPVSIANSYMQDVKVNYSKVLQNKSWDELANMYQGIGDQELAFLKTKSEAVPGDFNSQLQNSYEKMQRLAVGIEQVTLDQALYQGSFLEHFREIETHIVKILCLLHFAMVHRNLTPSVTINKEDMPQEYRDVEGQSAAREFRDFMILDNYFKSLQNLIQVFTEFENKRGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8J5K6N9_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G021793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019050">
        <property type="protein sequence ID" value="KAG7168776.1"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="247"/>
        </location>
    </feature>
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            <begin position="24"/>
            <end position="39"/>
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            <end position="103"/>
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            <end position="175"/>
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            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="490" mass="52545" checksum="05A6D93D5AB72414" modified="2022-05-25" version="1" fragment="single">ASVHLPQYAEPPPPPPPKRRQSSLPPPIREPPPPPPPNRRPSSSNTRRTSSSPNRRPSSSNTRRTSSSPNRRPSSSNTRRTSSSPNRRPSSSNTRRTSSSSPNKRQASSSPYAFQDSSSNSFQDSNSGGSQGSNTQQSQSASGSSSSASSSSSSASSSSSPSTSVLQVISSSSDGPPSNFTTTSVGSSVFLSYPRHFSHPLSPFSSTFNDLSSSSSVNLSPSSSSSGGPFPSSFPVSVTESSNNTNASPSTILSNASSFFSGLFSSPSSSSSSSLVDLFLDPVNLEKIKDAGLTAENEEEFLDHFLTVLTGEETRQGTALTLDPVTIISLLTLAAYMVRAVYQIMSVSNKSSSDTSRMLPFQLEERSIHHPLSTILTIPGNLAAIIKLQREGHQPCVRQFVCEQIKERAYPEVTVSDIFIAGLGYYFGEADLGTFIDGAVSGRYTCDFLPEGCSQRTLRDAHYLENLYSRASFKFFNLLSVFGNYLLPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K756</accession>
    <name>A0A8J5K756_HOMAM</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">Hamer_G011562</name>
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    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1059"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1145"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1198"/>
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        </location>
    </feature>
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            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1422"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1465"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1739"/>
            <end position="1758"/>
        </location>
    </feature>
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            <begin position="933"/>
            <end position="960"/>
        </location>
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            <begin position="1931"/>
            <end position="1958"/>
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            <begin position="21"/>
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        </location>
    </feature>
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            <end position="134"/>
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        <location>
            <begin position="1741"/>
            <end position="1757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7168888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1963" mass="219493" checksum="8D2BD91A415009FC" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7X1</accession>
    <name>A0A8J5K7X1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Techylectin-5B-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Tl5b-L3</name>
        <name evidence="9" type="ORF">Hamer_G012497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Malacostraca</taxon>
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            <taxon>Decapoda</taxon>
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            <taxon>Astacidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005577">
        <property type="term" value="C:fibrinogen complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:positive regulation of heterotypic cell-cell adhesion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF6">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="8">
        <location>
            <begin position="477"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="703"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="703"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7170926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="739" mass="85316" checksum="6086C5439A174D32" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KA82</accession>
    <name>A0A8J5KA82_HOMAM</name>
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        <recommendedName>
            <fullName evidence="3 17">Alkaline phosphatase</fullName>
            <ecNumber evidence="3 17">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Alpl-L4</name>
        <name evidence="19" type="ORF">Hamer_G011663</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3 17"/>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KA82"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000008">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15 17" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="551"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="14">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG7168973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="629" mass="68577" checksum="7B257557BA9C7794" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KA92</accession>
    <name>A0A8J5KA92_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Mucin-5AC-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MUC5AC-L9</name>
        <name evidence="1" type="ORF">Hamer_G025004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015240">
        <property type="protein sequence ID" value="KAG7169841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KA92"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF12">
        <property type="entry name" value="CHITIN DEACETYLASE-LIKE 5, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="126" mass="14968" checksum="E2AABE4C1F07E2A3" modified="2022-05-25" version="1">MGSKTDQHRRRYYSHQQSALRFVLPRRLVHDATPQGGIHRLPRHHRWHGRRLVHYQRLLQWMRNPTPLSSIKNFSFGCDYPDRKKCVSKKVCNVWHKGGVRYMRTCQCPETYPWTSNTGVASPLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KC24</accession>
    <name>A0A8J5KC24_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine proteinase stubble-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Sb-L6</name>
        <name evidence="6" type="ORF">Hamer_G022257</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018134">
        <property type="protein sequence ID" value="KAG7169165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KC24"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7169165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="139" mass="15499" checksum="5C6F0BAEF08D5A60" modified="2022-05-25" version="1">MTAAHCVEQSDHHFVRVGDADSEAFFSVEQKIIHENYDNHFEGYDIALLKMGISLDLSDNGLAPVCLPADTNHTYEGENAAVISWARTKIDQGKFASTLQEVDVVIRTNEACQKNKNEDIPDIFFCAETYDNVLCNVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KGD6</accession>
    <name>A0A8J5KGD6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Glutamate receptor ionotropic, delta-1-like 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Grid1-L27</name>
        <name evidence="14" type="ORF">Hamer_G016078</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014436">
        <property type="protein sequence ID" value="KAG7170275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KGD6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="13">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7170275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="177" mass="19675" checksum="4A1DDB343ECFD8FD" modified="2022-05-25" version="1" fragment="single">NNWPFFGLRYLPDGKPLADSGLDISVLNSLSHKFNFTYVVAEPEDGQWGGPQPDGSVTGIIGMVARHEAHLAINEITITASREKVVDFTHPYFLESTILVSRAPAPKNKAFAIFSPFTPLMWSLLAATTALMGPLVWILTTVLRSYTNHEEQHSLMNTPIPPRSSVQDLAFNMYRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MH29</accession>
    <name>A0A8J5MH29_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LIAT1-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">LIAT1-L3</name>
        <name evidence="1" type="ORF">Hamer_G010707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MH29"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="197" mass="21926" checksum="51947B71F158DEA8" modified="2022-05-25" version="1" fragment="single">ETQYDIWEKLEPYGFSNLGKLVLCQTLRSKDMRSDVLVGVVGGLGGGRRPPTEEYPPTGEDYPPRREMSAAWLYHVHDLTLKTLRAREHAVKNTLPHGLLHAFHAPPGVLLVFHAPPGVLHAFNTPPGVLHAFHAPLRLLHAFHVTPGFLRALHAPPQVLHAVHAPPRLLHAFHATPGLQHAFHTLPENLHAFHTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLR3</accession>
    <name>A0A8J5MLR3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLR3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="555" mass="62144" checksum="17F637F4D8A7DC06" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMM4</accession>
    <name>A0A8J5MMM4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cleavage and polyadenylation specificity factor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G019280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038152">
        <property type="protein sequence ID" value="KAG7157056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMM4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7157056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="404" mass="43062" checksum="2A2D23C682ABE048" modified="2022-05-25" version="1" fragment="single">WTTDNDIAAAVQNLGVNDFLDVKFFENRANGQSKGFCAISLGSDPSSRLVMEKLPRKEIHGMNPVVTFPSKQALNQVRISMLKPTAAVLSCDRFLILSLRAKLEQVLSINIVAALVVQVAIQVEAQGAPEDLECHHQVVACLHQGWNIDHQVRLGPTVHMEVHMAAHTEAPMGVPMVVLMVLMVHMVLLVDHMVLLVDHMVDHMAVPMVAPMVALMVAPMVAPMDPLDLMDLQVWVLIMDLTKVLHVDLHLTTCKVGRLWTNWGIEALVMEGPGPRAPPPPGHIQRPMHPGGPGGPPPGHGGPPPRGPPPNMGPPPGQHGPPPPRGPPPPMDPRAPPPRPDFIQGGFPATSSPPSVPHNLALPARPPITQGTLTTGLYGNGNALSTSVCAGLLVCGVGCPFSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMP8</accession>
    <name>A0A8J5MMP8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-GEF domain-containing family member 1B-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G025941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038618">
        <property type="protein sequence ID" value="KAG7156817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMP8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="3">
        <location>
            <begin position="40"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7156817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="192" mass="21543" checksum="92DE26FD97E0F00D" modified="2022-05-25" version="1" fragment="single">GLPQTPKSGAKSCPYNGVDRASHPPEWATAPDDDNSLVYEDGVLVSGSLQALVQHAVPTAVYYPDTAYLFAFLLSSRLFIKPHELLQRVCDEKLGRFVPHMVQLLGEWSETFPYDFRDERMMGGVRTMTHRCIALEPSLRRDVTQVLHNLLNKLTQLERYEEGLAKLSPPPPSDFIPQYVGVGQVLCVSMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMR9</accession>
    <name>A0A8J5MMR9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037867">
        <property type="protein sequence ID" value="KAG7157238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMR9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="47" mass="5593" checksum="E5B51BB0BB1531B1" modified="2022-05-25" version="1" fragment="single">MRQSQFDEIEDQARAFAEPVYTETTKRTKKRKHFFDESVGTETQLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMZ7</accession>
    <name>A0A8J5MMZ7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G005941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMZ7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="137" mass="15658" checksum="FA3D13150C0912FC" modified="2022-05-25" version="1">MESTRSKTEVWLIGQHITEITGAQLPSRGDVLRLFFHGHNEHKKTVNDSASEVAASVISFWNKARIPTITEKSIGRKVVDLFLMWKGLKKNCTRTTDTQRKKEETFCDELEDLFDVAHPKAMQLLTIKEDRAFLAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MN50</accession>
    <name>A0A8J5MN50_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolar transcription factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Ubtf-L</name>
        <name evidence="5" type="ORF">Hamer_G005790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MN50"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051762">
        <property type="entry name" value="UBF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46318">
        <property type="entry name" value="UPSTREAM BINDING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46318:SF3">
        <property type="entry name" value="UPSTREAM BINDING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7157370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="581" mass="68033" checksum="E246A568371B4BE8" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNJ7</accession>
    <name>A0A8J5MNJ7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CD81 antigen-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Cd81-L</name>
        <name evidence="7" type="ORF">Hamer_G014835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035946">
        <property type="protein sequence ID" value="KAG7157969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNJ7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF527">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7157969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="208" mass="23070" checksum="5E94F194EA9EBC0E" modified="2022-05-25" version="1">MSRGVEMTGCGKCIRFLMFAVNFVIWVASIAILVLGVWTVVDRPYLERLLGNDMYMTAAYILIATGCIVFFVSFLGCFGALREVKCMLLTYFIIVLLLFIILLIAGILGYVFKDKAETSVNHAMMNAMKEYRSGSNNTFTKAWDETQQALQECQTRPSESNSFTDGCFSMATDFVKQHALIIGGVGIAVAVIMVVGLMLSIILFKMIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPT1</accession>
    <name>A0A8J5MPT1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033595">
        <property type="protein sequence ID" value="KAG7159308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPT1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="93" mass="9803" checksum="6516AD31C48347B2" modified="2022-05-25" version="1">MVGSVNQLQPSSSTTTATCHHAPPTPATISLQNNYSDTKNKRLNGTYTCGLNSYSPGPGRDGTDVLRTGVNYVVSGYQYHLLPALSSSAGENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPV3</accession>
    <name>A0A8J5MPV3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly(U)-binding-splicing factor PUF60-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PUF60-L</name>
        <name evidence="2" type="ORF">Hamer_G016489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPV3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051974">
        <property type="entry name" value="PUF60_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330:SF1">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="249" mass="25122" checksum="F7D9BC43172679C9" modified="2022-05-25" version="1" fragment="single">AQTVIDEITEEANYYNRIYIASVHQDLSESDIKSVFEAFGKIKGPLSAPTQMPTAAAVAAAAATAKIQAMDALATNAIGLVQGLSSSPGSISQLPPVGVVGNVPPVGTVGNVSASVPSSPVAVLGGNSSSVPPVGVVTSLPNLGGPTSTATIPPPTVITSLPVPGTNSSSLAPPLPPSSNVGGAGSAGSNATVNSSSGGEDRKPTHQEELAKKLMEDNEPQTLQQQETMSIKGQSARHLVMQKLMRKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQQ9</accession>
    <name>A0A8J5MQQ9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Megakaryocyte-associated tyrosine-protein kinase-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Matk-L1</name>
        <name evidence="5" type="ORF">Hamer_G025658</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031515">
        <property type="protein sequence ID" value="KAG7160249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQQ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="147"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7160249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="372" mass="41362" checksum="8D7C1931352D1394" modified="2022-05-25" version="1">MKRLLCCKKPLTDSTSHSPQPTPLPTPTLTTPPLVSLTTPFLVSKSISIPPHTSFPTPCHSPPLTPHPFLPLTTSTRTALSRMSMSITTLPHCTPSTPPPSSTHTPLISPFPLSLIHSPSFSHPSHCSPHSNSPDYILLSLTEVQTMPVIRRLGEGTFGVVDLIKYNKDVKVLKKMKRVNYATFIEEVKIQRKLDGAGGAPRIHAVCQEDSSVIMDYTGITYDKYINYATTRQKVHTLVKIAEALCEIHQKNIFHNDLKIDNITITVEEKDSTVHIIDFGKATDHEKYINRGKISRYWIAPEFASGGVTSAASDTYSFGQLVRDVRDYITDNGLILELFDKIVDMTTCEDPLHRVPLTEVVRVMNECLPIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR48</accession>
    <name>A0A8J5MR48_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamate receptor ionotropic, delta-2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Grid2-L2</name>
        <name evidence="11" type="ORF">Hamer_G001782</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR48"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7160506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="259" mass="29057" checksum="3B6BA06D2FB4D395" modified="2022-05-25" version="1" fragment="single">LSMKTSSGRERLVVGGWMVVAMMLMWSYSGTLISLLAVRHVPQPLQSIRDVVQDSSVTVIMEPGIIDNDIISKIKSGDLKDLNDLKYVGRMKYQLAKENPQSMNTLVRHQRHVILGTTLSTNLLIANLFAKTEKCDFYKARQTFFITHHCMIGQRGNPIVPAISHRLRGLVESGMYEHWLFNSIPFVTSCRLSPSKITVKEALTLKNLWGTLVLLAAGLLLAFASFCLELFLANDVFVEFSLKVPSEREVMNGTLENSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR92</accession>
    <name>A0A8J5MR92_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR92"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="67" mass="6704" checksum="166208F834A91E36" modified="2022-05-25" version="1">MDSRVSRVGVGEATRKTGGGVGSSGFVDLKVMPPAAHTPVPNQSPLSDGQAAGGRQSKMLPALAIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRM2</accession>
    <name>A0A8J5MRM2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRM2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="35155" checksum="8C9C38C3524B898D" modified="2022-05-25" version="1">MPRKRKSSYANTPHAQRMRLRRQSESCDAREERLSRQRQRQTESRQNEYLGEHQERQEQDRFRHVVARRNESEEERQQRLIADRNRCICPRLESICKNPRSLMPPEDRRARYIQVYFLDTLEDQLRARGEHQNLNADILERITAWLNENNHYVRELKTALEEVRQGNINDKKIVIWENKRAQGEHARRFNAPTGAEVAILMSNEPTENRDIVLQLKQGGLRRISELHRSYDPLMYPLFFPYGTDGYHIYLQGRNGRKVTQLQFYSFHIMCREGNYLLLGRRLFQQFLVDDTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRX5</accession>
    <name>A0A8J5MRX5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029758">
        <property type="protein sequence ID" value="KAG7161151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRX5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035156842" evidence="1">
        <location>
            <begin position="27"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="314" mass="35692" checksum="D24BB33D6ED0E5F2" modified="2022-05-25" version="1">MATRRQCSVLAVWCWCLLARVTLVNTENTVERCVILKDGDLPTRFVPLPVNITTKPLTLGWRLDFTVHNKEEEEEEAPLVCVSIEVKDPDIRLSLFKGKCEGDVVDFHLWNLHEMKIGDWSTVQVTVNDSVINLQLGNNKPKSLTSRSVTLASDTLLQVSHKRSIDLAVGCPINCPAVRGSPASGNRLSTVKELKKRSEKFFFKPGREFARLNFEMKCETPLGHEVRFGDTTLTRDHIEELSPLSKWHYLFLQYDDEQNIFEIFINYRPAKTISVGLNICNTFRNFIVRAEGETFFSFTCDPTSGESQLLPPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSI4</accession>
    <name>A0A8J5MSI4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="13">GNT-I</shortName>
            <shortName evidence="13">GlcNAc-T I</shortName>
            <ecNumber evidence="13">2.4.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Hamer_G008103</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11456"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="2.4.1.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">The cofactor is mostly bound to the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.101" evidence="13"/>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSI4"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003827">
        <property type="term" value="F:alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047223">
        <property type="term" value="F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039477">
        <property type="entry name" value="ILEI/PANDER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052463">
        <property type="entry name" value="O-linked_mannose_GnT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396:SF2">
        <property type="entry name" value="ILEI_PANDER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15711">
        <property type="entry name" value="ILEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52031">
        <property type="entry name" value="GG_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ILEI/PANDER" evidence="15">
        <location>
            <begin position="153"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF15711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7162545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="680" mass="75582" checksum="8348544C9DFEB302" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSZ3</accession>
    <name>A0A8J5MSZ3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G025862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027183">
        <property type="protein sequence ID" value="KAG7162728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSZ3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="194" mass="19987" checksum="04A137868D1434BC" modified="2022-05-25" version="1" fragment="single">WGHVNTGWGHVNTAWGHVNTGWGYVNTTLTQAGVTLTQGWGHVNTQAGVTLTQPVVTLTQAGVMLTQAGVTLTQPGVTLTQAGSRWGYAPAWGRVTQAGVTLTQGWGHKLTQGIQPVVTLQHNLGVTLTQPGVTLTQAGVTLTQAGFTVTQPGVTLTQAGVTLTQAGVTLTQAGVTLTPAWGHVNTGWGHGNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTI2</accession>
    <name>A0A8J5MTI2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTI2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="143" mass="15075" checksum="D66A626CB856C69E" modified="2022-05-25" version="1">MAGIANVACVHELPVAGVDLILGNDLAGGQMGNVTPPPVLRERPESTTELQQLEDDMLGVFPLCAVTRSMSMTNDHNVTPDVDDSLSLEGLFANPIASQDISSEVNAVTGRVALIAAQEQDDSLRLLFDQVSDSANDSGPTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU52</accession>
    <name>A0A8J5MU52_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Meiotic recombination protein DMC1/LIM15-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Dmc1-L</name>
        <name evidence="12" type="ORF">Hamer_G003707</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. DMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU52"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19514">
        <property type="entry name" value="DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000239">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="25"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="11">
        <location>
            <begin position="217"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7164495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="280" mass="31097" checksum="9ED41396770B7A2E" modified="2022-05-25" version="1">MRVTAKLSGGEGFVTALVMCERRRHIFRVSTGSAELDTLLGGGIESMAITEVFGEFRTGKTQLSHTLCVTAQIPNDTGTYTGGKASHMYLFNFCKVIFIDTENTFRPDRLRAIADRFNLEQEAVLDNVLYTRAFTSEHQLEILDYVAAQFHEEPGIFKLLIVDSVMSLFRVDFSGRGELADRQQRLAQYLSRLQKISEEYNVSIFITNQMTADPGATMSFQADPKKPIGGHILAHASTTRVSLRKGRGETRIAKIYDSPELPENEATFAITAGGIADAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUI9</accession>
    <name>A0A8J5MUI9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Transmembrane protein 8A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Tmem8a-L</name>
        <name evidence="3" type="ORF">Hamer_G004653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7164930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUI9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7164930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="285" mass="32541" checksum="C8F66A45D853B9A5" modified="2022-05-25" version="1">MIRPKTILKASLSVIVIVSIADLLLRSYSTRLESDLHRVQVTCCRVFCDNKHTSRQRYDVPKCRSSLEELLRSLPLVGRLLKTTHPQLCPGELDGVWKLPVIHWIRKISEIRRQTLQVSTSCTGPIVPLSVIFLTAVFITVVVVAGLGCGLLVRRLWRRSSSEHEHNNKLKEKYKSVRARLYEPCRRTKLYRMQAQSDSSESSSSEEESSSSSYPDTKQKKRKKEKACSVSLVPEVSQEGLLQPYTTYADVTLFHFHIPDEVTRVTWEFAAFMDDPGCPVREVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MV09</accession>
    <name>A0A8J5MV09_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable imidazolonepropionase</fullName>
            <ecNumber evidence="5">3.5.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">amdhd1-L</name>
        <name evidence="13" type="ORF">Hamer_G003540</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MV09"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01296">
        <property type="entry name" value="Imidazolone-5PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000007">
        <property type="entry name" value="Imidazolonepropionase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752:SF1">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="35"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7164362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="383" mass="41102" checksum="2A5F408F9FB5F27B" modified="2022-05-25" version="1" fragment="single">IRDGLIAAVGFDKEVEEQFPGVSWAAVVEAHGRSVVPGLVDAHTHPVWAGDRVHEFAMKLAGATYMEVHAAGGGINFTVEHTRAASEEKLLQLLLPRLHRMSRAGTTLVECKSGYGLDVDTELKMLRVLEKARPHAHLTISSTFCGAHSVPRGLTAEEATRRVLEQQLPAVKSAKDAGELHVDSIDVFCEQGVFNVDQSRRILEAGQREGFFINFHADELHPLKGAEMGASLGAETMSHLEEVSEEGIAAMAKAGTVGVLLPTTAHILRLPSPPARAMINAGVPVALGTDFNPNAFCLSMPLAMHLACVIFKMSLNEALTAATLHAAHALRKAHAHGSIEPGKVADFVIVDAPRWEHLVYQLGGADHVISHVIKAGTVVHTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW02</accession>
    <name>A0A8J5MW02_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative PHD-finger-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Phf-L5</name>
        <name evidence="7" type="ORF">Hamer_G028994</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023231">
        <property type="protein sequence ID" value="KAG7165863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW02"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7165863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="272" mass="31241" checksum="5377B144E485BB17" modified="2022-05-25" version="1" fragment="single">MSETKDSGDRRKASVNKHGGKKNAEMCGECGLTVKDSDKAVSCDVCEVWFHIECEKLPEEVYNFMQDEEAEGVLMWYCSHCKKGCAKLHKLGTLEARTVGLEGKVDYNRATGSATEVKQEDNTGKPEPVDKLLELNAQLKGMENTPQVIAPQEVKPKHYRYERITAEYNREGYDIIEHNLLNKEGREQEIAKNVKANPKVFWKYSMYRQKQEHKLELRIFTANDQEKADVLSEQFSRVFIKEPDRGIPTANKKDGYHMYTAIKKTTVEKNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW26</accession>
    <name>A0A8J5MW26_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-lipopolysaccharide factor-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ALF-L8</name>
        <name evidence="3" type="ORF">Hamer_G024423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024722">
        <property type="protein sequence ID" value="KAG7165184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW26"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024509">
        <property type="entry name" value="Anti-LPS_factor/Scygonadin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038539">
        <property type="entry name" value="Anti-LPS_factor/Scygonadin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11630">
        <property type="entry name" value="Anti-LPS-SCYG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="1" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7165184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="303" mass="33085" checksum="6225A105521945BE" modified="2022-05-25" version="1">MVSGENVLPLSFISPITSFSLRLLTLLLLLLLLLTPFLPPSSYLQQICSKKATLPLQTTWAKPSCNTKNRPFSTRVSGPIPLDLASGTPHTCQRGNKDPASAVCLRDHWQASEDRILPGCWGGAAGVGEGLGGVSRGWVEGVGYEGEEGLGEWGGLGGVGRGWVEWGGLGVNTNSNHDCQDCQQKMQGRVLIGLVTVLLLAPQCHGKDWDELVPDVVKKLERMWQQGKGEVNLLGHPCILEVHLDDHKRHQATFTCPTLSDIQGRATSRNKFGVIQGIVHDYFKKAIKKEVITEVKVDHWLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW39</accession>
    <name>A0A8J5MW39_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023345">
        <property type="protein sequence ID" value="KAG7165831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW39"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="372" mass="41488" checksum="67B68F150A7A7B55" modified="2022-05-25" version="1">MVTRMLTKRPHTVEGLVLTSSPREGPVRLLILSSLCNPPTPNDSADPEPTHPPLTVVSTRRALCPHQLTTHILMCTTLTILTAQELCFVFCVAYMNRLAKAAVDRVNTLAFIHSRRNLWKNVNEGRQAGVPAAAPWTRPGGVGMGVHRRQAVSKKCSRTTVEEDSTVAREGLEKLQLEDQDLRPMVRYQVRGALEFSGEVMKRNHDVEASQVCYKDSDKVWLYNPQQKKGQSPKLQSPWEGPYTVMECLSDVTFRIIGRRKAQPKAPTTDDTRPYQTGDPGRTQDRIVPENPTMDQEEEHCCLLAELDVTEEGDRSEDVTEAAAPREDSVDIPKIMATVATGMTNALDSFQLWVTQKLKALEDKNSVSGEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW62</accession>
    <name>A0A8J5MW62_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pogo transposable element-like 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Pogo-L23</name>
        <name evidence="4" type="ORF">Hamer_G013123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024020">
        <property type="protein sequence ID" value="KAG7165622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW62"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018586">
        <property type="entry name" value="Brinker_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09607">
        <property type="entry name" value="BrkDBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="TrpR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="59"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7165622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="216" mass="25284" checksum="09859025F99E8E18" modified="2022-05-25" version="1">MAPIVKRRRYEACFKLKVIAYAQSHNNCAASREYGVTEKMVRDWRSKEHLLRSMPRNKCAMRRGTAHWPILEKHAVDMVHEQRQNGYIVSRNMIRMWALKWAKQNQEHSKDFKATASWCSRFMERSNLVLRQKTKIAQKLPADLNFIKSFKKCGISNSMDGMEDDMLWEDEDETEAEATSSDLEFDPYDEAAINVSQDVLEELMMSDVDDVDFEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW83</accession>
    <name>A0A8J5MW83_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Tigger transposable element-derived protein 1-like 280</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TIGD1-L280</name>
        <name evidence="3" type="ORF">Hamer_G010417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW83"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035165636" evidence="2">
        <location>
            <begin position="32"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="326" mass="37513" checksum="FA9A9C1DC848C403" modified="2022-05-25" version="1">MLMMMMMMMMMRMVMMMMMMMMVMMMGKTLGNKSPRVASNIPNKRPWTKRAAVGWRAGYPITPRILMMQSYENDNRATTDRISDAPPVHRPQTGGDKYAIWSAKKKRLVEIMHPAWREVTVRCLCAAWRPLWPECVLQRDFEGFEELEEEAVVHEIVSLGNSMGLEVDDDVEKLVEEHNKELSTEELLELHKEENETLKRSLTSEESGEEEDKEESRIIPAKDLKDAFFCWSKLSKLAEDYHPDVGSVQKAIKGPHTSSQQSQLSFHPLRHFPHRCLSPPPPAVITRSSVVIKIIITPRQQVIDTRSHEVLTYDTLTNDTLTSDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWL2</accession>
    <name>A0A8J5MWL2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Transposable element Tc1 transposase-like 53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tc1a-L53</name>
        <name evidence="2" type="ORF">Hamer_G020421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023767">
        <property type="protein sequence ID" value="KAG7165739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWL2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="131" mass="14979" checksum="855112773A26DE3D" modified="2022-05-25" version="1" fragment="single">RRPLPRLTTRDEDAAIKAAIQNNPFSNPVAIREAFLLDVCAQTVRSCLHEADIQHRVPAIKERLTDQHRTGRLQFAQQYVGEDPEFWSNTTGRTYTVRGGQKWACDAERVRLHIPARYGRCFPNSGEVYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXS3</accession>
    <name>A0A8J5MXS3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transient receptor potential cation channel subfamily A member 1-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Trpa1-L10</name>
        <name evidence="12" type="ORF">Hamer_G021742</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021942">
        <property type="protein sequence ID" value="KAG7166924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXS3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF3">
        <property type="entry name" value="PWWP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="11">
        <location>
            <begin position="12"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7166924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="265" mass="30985" checksum="DD42DBCD816C37D3" modified="2022-05-25" version="1" fragment="single">EWQWQTGAMAIFLAWMNLLLFIRVFPFFGIYVIMFTEILSTFSSFFLVFFFFIIAFALSFYTVLGEQYPFRTPAHSLLRTAVMMIGEIDYQDVFSNPENPIEYPEVTYILVMAFMVFMSILIMNLLVGLAVHDIKSVQEQAMLQKLAMQTKLVVEIEMVIPEYIRRRYVVKNLKVVEENKTNILRWLFAKFSFYQEKELSDVDNLRQEVLQLKSSVDDLLDIKASLHDLGEVKDSLRILSDLRSSKTDLVQLKNLVKEIHKKLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZ57</accession>
    <name>A0A8J5MZ57_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G029927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019124">
        <property type="protein sequence ID" value="KAG7168754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZ57"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="118" mass="13482" checksum="B079443BB529DF2E" modified="2022-05-25" version="1" fragment="single">MVKTKQSNGEQFFLLLFSFYCSSFTSNPLKTIGRNDIEALGSKSRCNSGKCNPELVCMVNRPGLFLGNAQKFVEQTIDLYQLILFLSSSSFRICKLLLQLQILFMDLLFCSNWFPWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZL6</accession>
    <name>A0A8J5MZL6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017704">
        <property type="protein sequence ID" value="KAG7169251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZL6"/>
    <dbReference type="OrthoDB" id="5946254at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38564">
        <property type="entry name" value="SI:CH73-250A16.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38564:SF2">
        <property type="entry name" value="WU:FC46H12 PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035197749" evidence="1">
        <location>
            <begin position="24"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="172" mass="18901" checksum="6E1978D73788473D" modified="2022-05-25" version="1">MGCCKCCCFTLLVIIIIVAISSGLLTAFFPYPSHASCRVDWIFGKPCSDVKSTLISQMKAWSHDDCSLKQQCNYEYLGEEGSTIRGLHVTPWISFVDKINFTFNAASGGNCYVQAASESAAAYAVIDFGVNYCNLRNLVIGSKLDENDSSYKENSTNAVCTMYSIAHCNLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0K2</accession>
    <name>A0A8J5N0K2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein heavy chain 3, axonemal-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Dnah3-L9</name>
        <name evidence="3" type="ORF">Hamer_G027366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013925">
        <property type="protein sequence ID" value="KAG7170554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0K2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF70">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 2, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="2">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="154" mass="17660" checksum="BCCE7B30FAB075BF" modified="2022-05-25" version="1">MDSSPMTLFGYFNERVRANLHLVVAMSPIGDTFRTRLRMFPSLINCCTIDWFTAWPDDALEMVATSLLQETKLEASLLAHCVTVCKYFHHSIDDLAHRYVTGLEKLKEAKLLITELQEELKLLQPCLVETSANTEALMIKIEQDTIQVERKQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0P0</accession>
    <name>A0A8J5N0P0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tubulin polyglutamylase TTLL4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Ttll4-L</name>
        <name evidence="7" type="ORF">Hamer_G016074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014436">
        <property type="protein sequence ID" value="KAG7170272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0P0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000009">
        <property type="entry name" value="tubulin polyglutamylase TTLL5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF162">
        <property type="entry name" value="TUBULIN MONOGLUTAMYLASE TTLL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="811"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7170272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="949" mass="106568" checksum="69CDD85F728718D5" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0T4</accession>
    <name>A0A8J5N0T4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaoptin-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">chp-L2</name>
        <name evidence="7" type="ORF">Hamer_G016162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014436">
        <property type="protein sequence ID" value="KAG7170346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617:SF178">
        <property type="entry name" value="ASTROCYTIC LEUCINE-RICH REPEAT MOLECULE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1240"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="6">
        <location>
            <begin position="1127"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1209"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1210"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1224"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7170346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1363" mass="152131" checksum="84106F314416145A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0Y3</accession>
    <name>A0A8J5N0Y3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Immunoglobulin domain-containing protein oig-4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">oig-4-L</name>
        <name evidence="3" type="ORF">Hamer_G013823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012455">
        <property type="protein sequence ID" value="KAG7171353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0Y3"/>
    <dbReference type="OrthoDB" id="6127080at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF4">
        <property type="entry name" value="MYOPALLADIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035248060" evidence="1">
        <location>
            <begin position="24"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="76"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7171353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="161" mass="18380" checksum="8DD19EA9FBF5F7C3" modified="2022-05-25" version="1">MKAYWAWVVLLLVLVVSVGVTEGKRGKGRGKKGRKNMSNRGSITKFKSEDSRAYYNHNGGAKITIWSHFESEYVLGRKIVFMCKAEGEPRPVITWFKDGIELYAHSFFQVHEWKEGKVSIKSKMEIDPATQMDAGYYECQADNKYAVDVKGFSADYSIEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1A8</accession>
    <name>A0A8J5N1A8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Disks large 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">DLG2-L</name>
        <name evidence="2" type="ORF">Hamer_G021160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012219">
        <property type="protein sequence ID" value="KAG7171409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1A8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="191" mass="21137" checksum="BDF280862B559AD2" modified="2022-05-25" version="1">MNVEPHLYKQQGWYVTPGHHLTPVTTLLQSPPYSSHHLTPVTTLLQSPPYSSHHLTPVTTLLQSPLSLPVTTLLQSPPYSSHHLTPPPYPVTTTSPPTQSPPYSSHHLTPVTTLLQSPPYSSHHLTPVTTLLQSPPYSSHHLTPVTTLHIKNERLSYCISTQCYSFNTSFTFEPFLEMFLSIGLKSGSLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N231</accession>
    <name>A0A8J5N231_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N231"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="98" mass="10788" checksum="8848B155F0B50C4F" modified="2022-05-25" version="1">MLQQLLGSALVAVQVLLSRDRARTRRNGEAGSVRSEVVAFLARIRFLAMTEEKFIHQVLPIGVLKCQESDAVLKVMGGIDGATQPLVAPCTNREERKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2P4</accession>
    <name>A0A8J5N2P4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N2P4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035302059" evidence="1">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="122" mass="12886" checksum="1D76801D1586EEC7" modified="2022-05-25" version="1">MVVMVLVLMVVVLMTATMASPVPDPSFRSYGYRSYGGYGGHGGYGGRSFGHGGFGHGFGRGFGHGFGNGFGHGFGGHRFGGFGYGKWCWTVLVADHALPAHCNDYLGGELYLAGVPLLNDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3W0</accession>
    <name>A0A8J5N3W0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G007004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3W0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035238150" evidence="2">
        <location>
            <begin position="17"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="170" mass="19008" checksum="42C0A0D57DDD2840" modified="2022-05-25" version="1">MVLTVMLVCLLVETCWKPFSNDPEHRESVDINGGTTGSSTTPRDPLVYTEAPPSYEEILAQEQLEPPSGNASDDLASTKCDNVTLYHLHTSILDMPDSPESATSNQHISLPRRYSPFITETRYSYTTANELQLSVDRLPSYEEAAITLQPLDSPQHQQNTTNDDDLMLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4J3</accession>
    <name>A0A8J5N4J3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010116">
        <property type="protein sequence ID" value="KAG7173201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4J3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="357" mass="40855" checksum="F5F0604C63074CFA" modified="2022-05-25" version="1">MKIYITTVGRSTSNFSKPLKSLPEITLTQLTPGQDANLPLSRAGWLVATPVRTFRLTLGFILAYMTIPRRLPEQQQDRRNYTDKELINDMIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDSSSDEQEATSDDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERREVVPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6I2</accession>
    <name>A0A8J5N6I2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-dependent RNA helicase DDX49-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Ddx49-L</name>
        <name evidence="9" type="ORF">Hamer_G020153</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009549">
        <property type="protein sequence ID" value="KAG7173528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6I2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="44"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="226"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="439"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7173528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="470" mass="53251" checksum="9BC9BE8906372F93" modified="2022-05-25" version="1">MADVVSQDTRGTTYADITGLQPWVIEQLNQLKIHQPTPIQYHCIQPALEGRDVIGAAKTGSGKTLAFVIPILQQLSIDPYGIYALVLTPTRELAFQIADQFRGLGSPVSLRLTVIIGGLDRVAQGAELNRSPHVVVATPGRLADILETSPEFTLKRIKFLVLDEADRLMDGRFDTQLRTIWAALPEKRQTLLFSATVTDRLQRMKQLATSEVFLWQSTNKQATVQQLDERYALVNPIVKDATMIATVLQHTEEKPRGLILIFTNTCKSTQKERLSALARFKSSQVKVLIATDVASRGLDIPLVELVINHTIPNLPKNYIHRVGRTARAGRAGQAVSFITPHEIKILLAIEAETRQKMTELKMDEAVVRKIMKQVNVTRREQEIKLNQTDFDERRNINKRKRLIMEGRDPDEEEKKKQKRVKKLRKAERKERIQLIEELEKKKKKRQAGKGSHISEGVADEKIKEPKSPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6R2</accession>
    <name>A0A8J5N6R2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adhesion G protein-coupled receptor B3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Adgrb3-L</name>
        <name evidence="10" type="ORF">Hamer_G022913</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007332">
        <property type="protein sequence ID" value="KAG7174696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6R2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="652"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="676"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="716"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="8">
        <location>
            <begin position="397"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="615"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="820"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="871"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="834"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7174696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="902" mass="100549" checksum="B577612230808776" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7X8</accession>
    <name>A0A8J5N7X8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bride of sevenless-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">boss-L</name>
        <name evidence="9" type="ORF">Hamer_G024779</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007296">
        <property type="protein sequence ID" value="KAG7174709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7X8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005118">
        <property type="term" value="F:sevenless binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002956">
        <property type="entry name" value="Bride_of_7less"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01223">
        <property type="entry name" value="BRIDEOF7LESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035259721" evidence="7">
        <location>
            <begin position="29"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="8">
        <location>
            <begin position="445"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7174709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="769" mass="83461" checksum="46AA5685D23C08A6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8C3</accession>
    <name>A0A8J5N8C3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-methoxy-6-polyprenyl-1-4-benzoquinol methylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">COQ5-L</name>
        <name evidence="6" type="ORF">Hamer_G015124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with PYURF; the interaction is direct, stabilizes COQ5 protein and associates PYURF with COQ enzyme complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7174927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8C3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7174927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="237" mass="26750" checksum="AA9495D61659E042" modified="2022-05-25" version="1">MTSLPARLFKFTPRITSVIPRYKSTASGYAKEEYSADKQTHFGFENVSQDQKAEKVHGVFENVASSYDLMNDLMSGGVHRVWKDYFMSRIDLIFPSGDIAFRFIQHVLHSHRGGKTLRNSWEEPDDATSPSGSQKADDSLPPYEITVCDISQNMLDVGQTRAKELGYKGITWVCGDALKLPFPNDEFDCYTIAFGIRNVVDVEKESFKEMIEDVGFRNTSYLNLTFGVSAIHSGFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8Q8</accession>
    <name>A0A8J5N8Q8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7175985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8Q8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="152" mass="16299" checksum="0CEE6EC6993E2514" modified="2022-05-25" version="1" fragment="single">SIGGALGICISGYEVSPGASEFLVPCIGNNWTLPTDQDGHPITCHPICFPSCRNEGVCVAPNKCKCPSTTRGTFCERLAGSECTGRPITPKGMNLSAWSENVYGLTCPDNYVLPGRGLGVSLRVTCIKGKWLYPDWKGHLPLTCEPYCLISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9M7</accession>
    <name>A0A8J5N9M7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartate--tRNA ligase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DARS2-L</name>
        <name evidence="8" type="ORF">Hamer_G024896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005082">
        <property type="protein sequence ID" value="KAG7175631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9M7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001750">
        <property type="entry name" value="PRK00476.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="GAD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="173"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7175631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="631" mass="71260" checksum="BEF1B933977F88E4" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA40</accession>
    <name>A0A8J5NA40_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G009902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA40"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="205" mass="23042" checksum="1A4795422E99B874" modified="2022-05-25" version="1">MSEIRTSPIQVPQKSEMWHLQPKPQDRNVHSKTQGRNHHDSEVPKLWKETSRLEHIMPREERADESCNGKNSTTKHNRSTSEHIRVGSTATENSQPNTHPTPTVRGFLPCTSFTRLQDKIEVTGTKSVHAGNHDKSVDSTTAAPELYNSKGTEHSSIGGEHHIAWDTITPSGDHPTEYTPACQSTSSIHRRTNKTDDHHYNSDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NB39</accession>
    <name>A0A8J5NB39_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gamma-aminobutyric acid receptor subunit beta-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Gabrb-L10</name>
        <name evidence="9" type="ORF">Hamer_G028653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002321">
        <property type="protein sequence ID" value="KAG7177381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NB39"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="755"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="783"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="813"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="890"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="8">
        <location>
            <begin position="286"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7177381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="912" mass="102705" checksum="5E6041BF0FC45C97" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBD2</accession>
    <name>A0A8J5NBD2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate receptor-like 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Glrk-L39</name>
        <name evidence="16" type="ORF">Hamer_G009147</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBD2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF38">
        <property type="entry name" value="IONOTROPIC RECEPTOR 100A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="344"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7176351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="712" mass="80472" checksum="AB607626D2EE9820" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBP9</accession>
    <name>A0A8J5NBP9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003232">
        <property type="protein sequence ID" value="KAG7176501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBP9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="89" mass="10276" checksum="BC2A75677848016D" modified="2022-05-25" version="1" fragment="single">IPSDRTGFSAFELLYGRAVRGPLSVLRDLWEDTSIEDDERTHYQYVLELRDKLSQCAKIAAQNADISNTKYKAYFDVKSQDRQFIPGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCW3</accession>
    <name>A0A8J5NCW3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein PLAG1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PLAG1-L</name>
        <name evidence="15" type="ORF">Hamer_G000146</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCW3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000425">
        <property type="entry name" value="PLAG1 like zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000231">
        <property type="entry name" value="PLAG1 like zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000256">
        <property type="entry name" value="PLAG1 like zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF35">
        <property type="entry name" value="FEZ FAMILY ZINC FINGER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="36"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="355"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7176938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="584" mass="63933" checksum="5CA1DA4948DC0013" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5SZT4</accession>
    <name>A0A8J5SZT4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="13">GNT-I</shortName>
            <shortName evidence="13">GlcNAc-T I</shortName>
            <ecNumber evidence="13">2.4.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Hamer_G014650</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11456"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="2.4.1.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">The cofactor is mostly bound to the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.101" evidence="13"/>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5SZT4"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003827">
        <property type="term" value="F:alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047223">
        <property type="term" value="F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039477">
        <property type="entry name" value="ILEI/PANDER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052463">
        <property type="entry name" value="O-linked_mannose_GnT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396:SF2">
        <property type="entry name" value="ILEI_PANDER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15711">
        <property type="entry name" value="ILEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ILEI/PANDER" evidence="15">
        <location>
            <begin position="127"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="217"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF15711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7171525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="616" mass="69394" checksum="09F864AA714F0DBC" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T640</accession>
    <name>A0A8J5T640_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009997">
        <property type="protein sequence ID" value="KAG7173339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T640"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="130" mass="13278" checksum="3BF1181E58F48E1E" modified="2022-05-25" version="1">MENQLKEKDAIPLQLSPTEIAADSVTTVEQSSDTGGDVTYSDTGATAAAEQSSEGDSGTGDKSSDTGGAVAAAEQSFEGGAVADLGTAEKNADIGGAVADSDIGVNYFTLPNSEFYDKIMEKRKKKKGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TCA5</accession>
    <name>A0A8J5TCA5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pro-resilin-like 118</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G020028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008712">
        <property type="protein sequence ID" value="KAG7173880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TCA5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7173880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="500" mass="55015" checksum="322ED5D561F4D84B" modified="2022-05-25" version="1">MAVRHSSSQQHLEDGEREMPQIFTQLEDINEIFGDNRRPSRRGGQDRRHSNPGGVGRRRSGGDGDLTPPVRHLPATVNTQVLLLLAGLTSSSVATDEGCCDDHCPLPIPTLEAEEGLHGDQHQDLKDDLHHDQFKDQDFFTFTSANFLPEDEEIENLKSEHIYTETDDDDSDDEDDDDNDGDGDSDSTTSAAAPPVLAPSQLPPPASTLSRRPTDAPPSTSCARYQFSYAVSHYQNQYGHQETRDGGHVSGVYHVLLPGGTRQVVRYYADDTGYHPTITYEDAYNIDPRSVTNPPPPPPSLSTTTRLALPLTNTPSSNTRPDRHYTKLPGLNSQDRQYITTESTAAQVYSSVSALYTVRLEENVFSKYSPYSHYLSTSSDFSHSLDTSVRNNSGISRSSSGFSRPSTAVRPDSQSPSGRTPSFFQRGLLVTPLRHITAESTPTRYFIPSQNVIHSGNNNIAGRRNFPLVPLRQVSQVHAEPRTTTVSVRLLVGASGEDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TID0</accession>
    <name>A0A8J5TID0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G001344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TID0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361:SF2">
        <property type="entry name" value="DUF885 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="GLR0591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="317" mass="35516" checksum="FC118B12040D0BC1" modified="2022-05-25" version="1">MAAADEYSTTSHVLQLCLALQDRLEKVEKEVQSLKGENLALKLVFEEKKTFASVVKDGEVEVDSWKVVAASATKCTLKRHSAVDLNNRFSTLSDECEEGTSNTTSATPSVSVERGSSAANVGGVPVSGSCARLQPAVQKLADDYFNWRMKNKPEFASFVGIHDYDDQLDDMSLEAYQGRYDQCQVFLDQAEALESNITDHDNLINIRALKNELITYMDGFPYQGFLVPLSYSEGIHVDFERLITWMVFKTSDDYENLLSRYKKLPEQLKQIQTLMEMGVTTGYVNHAISMMAEGHLANGRFTDGHLTERTSSRRTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKB2</accession>
    <name>A0A8J5TKB2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="5">eIF3f</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Eif3f1-L1</name>
        <name evidence="7" type="ORF">Hamer_G018926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009009">
        <property type="protein sequence ID" value="KAG7173777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKB2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000014">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7173777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="284" mass="31629" checksum="5E091632BE21BA94" modified="2022-05-25" version="1">MALNLVAKVHPVVFFTIVDSYERRNPDAHRVIGTLLVVVHPSGTIGVDKGAIEITNCFCVPHNESKEEVAVELDFAKDMYELHRKVNPGEVIVGWWATGHEITDHSLLIHDYYSRVTNNPIHLTVDTTLHGGRMNIKGYVSASMGVPGRTPGTMFAPIPVEVISYAPEIVGTNATQKSKYSRQRLVDPTTDLHQISEATQNMEATLETLISYVDDVLSGKVPADNYIGRELTRMVNQVPKMSAHDFEEMLNTNMKDLLMVIYLSQLTKVNVSLNEKLTMLVATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKH8</accession>
    <name>A0A8J5TKH8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="5">dUTPase</shortName>
            <ecNumber evidence="5">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Dut-L2</name>
        <name evidence="7" type="ORF">Hamer_G016744</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010002318">
        <property type="protein sequence ID" value="KAG7177449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKH8"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="6">
        <location>
            <begin position="113"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7177449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="205" mass="22770" checksum="C77ACFCF25E69DF4" modified="2022-05-25" version="1" fragment="single">LSVVVVGFLEANPLASAQFENFAVLLPTVSRLICAMDKRRRKKKEKKKVTFVSEPQIVYSQLDAAHSHSSFAESTNNNKVYLRRMNKKNVENVKEQQQNGHGCNKIRLAGKNAYNIVIPGQGKAPIKTDIQVELPEDCYGRVAPRSGLSWKNHIDIGAGVIDRDYRGNVGVVLFNHAKTDFEELVDTERGADGFGSTGRNKKSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLI6</accession>
    <name>A0A8J5TLI6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007499">
        <property type="protein sequence ID" value="KAG7174662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLI6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="170" mass="19677" checksum="40AE5C162EAEF916" modified="2022-05-25" version="1" fragment="single">MTSDYLYWRSPLLAITSTGDHLYWQSPVLANTSTGDHPAWRSPHWRSPLLAITSTGDHLYWRSPLLAITCTGEHFYWRSLLQYILRTIMRRKSIKVRERRSTFTPHYQSCVMTYRDGLAWAGDTVTKVTEKKRKKMRQEEKEEGRGGEKENDKEREGKKEGGEGGRGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TTP9</accession>
    <name>A0A8J5TTP9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="1">Heart &amp; testis</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TTP9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="117" mass="13311" checksum="9E3929BF345D1176" modified="2022-05-25" version="1" fragment="single">MTKPDLVFQKGSVLSHVDYHGEVDDHIYIQSEALPGVPFYIQIDGYLEKGKPFSRISPTLAIPVESQIELLVESSVLYATPGQSTKAYFRVHNYGPEAQFKYTATDEAKYIYHWNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TU52</accession>
    <name>A0A8J5TU52_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial import inner membrane translocase subunit Tim17-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Timm17b-L</name>
        <name evidence="13" type="ORF">Hamer_G000580</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCY8</accession>
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            <fullName evidence="4">MAP kinase-activating death domain protein</fullName>
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        <name type="scientific">Homarus americanus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="3">Belongs to the MADD family.</text>
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        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7154458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1472" mass="156537" checksum="ED6065E6BEF2EF8F" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDW0</accession>
    <name>A0A8J5JDW0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Death-associated inhibitor of apoptosis 2-like 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Diap2-L13</name>
        <name evidence="2" type="ORF">Hamer_G032128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040436">
        <property type="protein sequence ID" value="KAG7155791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDW0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043027">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF174">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="909" mass="96619" checksum="E7918E425469057C" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDW8</accession>
    <name>A0A8J5JDW8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vesicular acetylcholine transporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">VAChT-L</name>
        <name evidence="12" type="ORF">Hamer_G022366</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043579">
        <property type="protein sequence ID" value="KAG7154886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDW8"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005277">
        <property type="term" value="F:acetylcholine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17383">
        <property type="entry name" value="MFS_SLC18A3_VAChT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000109">
        <property type="entry name" value="Putative vesicular acetylcholine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00880">
        <property type="entry name" value="2_A_01_02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF13">
        <property type="entry name" value="VESICULAR ACETYLCHOLINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="40"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="542"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7154886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="584" mass="65016" checksum="35DDE3E527DDC04F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JH18</accession>
    <name>A0A8J5JH18_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006530</name>
        <name evidence="3" type="ORF">Hamer_G025756</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010028968">
        <property type="protein sequence ID" value="KAG7161533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JH18"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036271843" evidence="1">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="72" mass="7672" checksum="6342A314FC7A79DC" modified="2022-05-25" version="1">MKTPATLTSTLLVFILVIALAGHGVSSSPLPQPSNRQERFFLPFNFNLPKFTTTTAAPAVVAPGITITFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJQ9</accession>
    <name>A0A8J5JJQ9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine/threonine-protein kinase S6KL-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">S6KL-L</name>
        <name evidence="8" type="ORF">Hamer_G004058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJQ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="84"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7159432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="667" mass="74842" checksum="6806840C8B562D6B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JK46</accession>
    <name>A0A8J5JK46_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Programmed cell death protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Pdcd5-L</name>
        <name evidence="2" type="ORF">Hamer_G019157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037402">
        <property type="protein sequence ID" value="KAG7157526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JK46"/>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="123" mass="14023" checksum="2BFDB4F8589594CF" modified="2022-05-25" version="1">MSGDKELEAIRNKRMQELQSMQGQHQQQEEMQQQQQQAINGLLNQVLDQQARARLNTIMVAKPEKGRQMESIIVQMATSGQIGGRLSENDLISLVERVNAQTQKTTSVKFDRRRAALDDDGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JM82</accession>
    <name>A0A8J5JM82_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G032144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035713">
        <property type="protein sequence ID" value="KAG7158095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JM82"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="108" mass="12635" checksum="BD607EA850BB88B4" modified="2022-05-25" version="1" fragment="single">SEVETKAEIEKENAWAENKVDHVKIFTSKKGKWIIKIQFKSTEVAEKATNSGLLAFTYSIPYHQIQQEQYHHTRTCFRCYASDSVNCPKPKEYKTCSKCTSREHTWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMB9</accession>
    <name>A0A8J5JMB9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor A domain-containing protein 8-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Vwa8-L2</name>
        <name evidence="3" type="ORF">Hamer_G007737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000663">
        <property type="entry name" value="von Willebrand factor A domain containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039891">
        <property type="entry name" value="VWA8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610:SF9">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="1333"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7160952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1522" mass="168875" checksum="0BA65C5371895B31" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMU2</accession>
    <name>A0A8J5JMU2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMU2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="155" mass="15933" checksum="0024A06A18875ED8" modified="2022-05-25" version="1">MTCGVLGQVHMTCGVLGQVHMTCGVLGQVHMTCGVLGQVHMTCGVLGQVHMTCGVLGQVHMTCGVLGQVHMTCGVLGQVHMTCGVLGQVHMTCGVLGQVHMTCGVLGQVHMTCGVLGQVHMTCGVLGQVHMTCGVLGQVHMTCGVLGQVHMTCEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPD0</accession>
    <name>A0A8J5JPD0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Ankrd52-L1</name>
        <name evidence="4" type="ORF">Hamer_G026459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033584">
        <property type="protein sequence ID" value="KAG7159310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPD0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7159310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="371" mass="41012" checksum="66588C2A5EFB47A6" modified="2022-05-25" version="1">MSFHRLYPNVVTWAGETPADLARRAGHRDVLRNFSSNNNHRFKGHQMGCTTSCYLSSPKGRLQAGVSSVVFRSALESPSGSSTQPFWPLPAFLHVLEYERTNMTHFPEVEEGVGQLISTMRCDNSWRASWPSGGSVFHLTELMVQAVRSNCTLTCSFIHEAGGQSSLCTESGVSPLHAALEAGHWNLARQMLKNLGGCLYVTDFGGRLPTTMMSSHLRQQLEQNIYDKERIQLEDLHLKIKDKVEKQQVQELLRVQKNLFNTYWGTITGNTATTIGEEPFNKAKVLLTASQGGMLQLIYLLVKVGGVEVDTQVDPTNGTTAIHQAASHGKSGSVLLLLSLGADPLLDDLYKQTAPHLAAMFGHQKAFELFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPH2</accession>
    <name>A0A8J5JPH2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Elongation factor 1-alpha-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Eef1a-L1</name>
        <name evidence="11" type="ORF">Hamer_G014141</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPH2"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000090">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7161580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="461" mass="50775" checksum="47AC85B233F8FCDE" modified="2022-05-25" version="1">MGKEKVHISIVVVGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKESTEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETKRFYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKHGQTREHVLLCFTLGVKQLIVAVNKMDSTEPKFSEARFEEIKKELNAYVKKVGYNPAIVPILPISGFNGDNMLEQSDNMTWWKAKKIERKNGSYEYTTLYEALDNIDPPARPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILKPGMVVNFAPTGPTTEVKSVEMHHEALVEAVPGDNVGFNVKNVSVKDLKRGFVASDSKNDPAKEASDFTAQVIVLNHPGQINAGYTPVLDCHTAHIACKFYELLEKIDRRTGKVLENGPKTIKSGDSCTVKMVPSKPMCVETFQKYAPLGRFAVRDMKQTVAVGVIKEVTKKEGGGKTTKAAEKALKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQQ4</accession>
    <name>A0A8J5JQQ4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative olfactory ionotropic receptor IR4-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Ir4-L8</name>
        <name evidence="3" type="ORF">Hamer_G007897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQQ4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035161111" evidence="2">
        <location>
            <begin position="30"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7162375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="483" mass="53560" checksum="7D156C761DB37734" modified="2022-05-25" version="1" fragment="single">FFLQFDKVTIMARMLLLLMLLSVVSMGVSQLPLSGMETLSVAGKAVGDVLKQCHILTALSSSLTDGSIPTTTFSMKIAQARAPWGITARSNNESYNTNVTQAAISEVVKAPAAAVMELTVVVVSYDPAFLAAFAEWFLRAASSVVDEALVVTRLPLKGLNFLHATLSVTNSMLIIVEKPQNHQVVVYPTALQPPRWPTVESCSLDAPPRPLTSHLPLFPDKFSRLHTGPNFVAEEFEPHIALVKSQMEATCSIVHRTNGQLAGDTSQQDSGGSWEVEVCRDESLGLPYCPWHRWWVGILTAMLVVPAVVFFLWSITGLRNNDDTVSSSDMFFVTFKVLQQGCGILACSEKIADWNLKDALSIGRSTEFPSSIDIRQEWRPRLDSRGSIKAVTRQDCTPVDLENYMPNATFCAHPPTKITVNTSLTPQPLDVRSDPRRTRRQQPYIGARAPKMLDYFLPSECTITRRREMIFTLVSSITWQEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JR74</accession>
    <name>A0A8J5JR74_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JR74"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="66" mass="7047" checksum="DB1EE017815F234F" modified="2022-05-25" version="1" fragment="single">ANAAKIKASCVAGKTLRASKSSTPKKQTEDTEPQPSTSGIRRFFLPSHATKTAPDDDNTDDNNSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRB1</accession>
    <name>A0A8J5JRB1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative Cytochrome P450-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Hamer_G018291</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027102">
        <property type="protein sequence ID" value="KAG7162765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRB1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="167"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7162765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="411" mass="45632" checksum="ACE056C520EA6D11" modified="2022-05-25" version="1">MAAVGVVSLGTRLGCLHPDAHDHQGHHDLSSTRASRVITANQNILELLGESMFLPPFYKYFPSRMYRRLSHAQDTIAGIVQEELMLRQEERAQDPEAFSFHHPFLDSLFSNSQLPTMDVFLLLVEIFQGGIDATFVTSPPVVACHDPQVFPQPDVFWPERWLSTYSRTTSSTHTTPTQDPPPAHHNTPTQNPPPSHHNTSTQDPPPVHHNTPTQDPPPAHHNTPTQDPPPAQESQEDASGKRIHPYTIVAFGHGARMCPGRRLAELEIKFECVTYLNTFPPSDSVSSNTYAGGCPQSFQGCPQSFQGCPQSFQGCPHSFQGCPHSFQGCPQFFQGCPQSFQGCPQSFQGCPQSFQGCPQSFQGCPQSFQQYTLHTLRPPSVVLRSRTCLEHRDQSILPVSSVCCLTLDRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JS08</accession>
    <name>A0A8J5JS08_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thyrotropin-releasing hormone receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G017400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7159959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JS08"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF25">
        <property type="entry name" value="CNMAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="749" mass="82779" checksum="DD8ECA4E2716554F" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029851">
        <property type="protein sequence ID" value="KAG7161133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="103" mass="11740" checksum="24E0C7F448C4F225" modified="2022-05-25" version="1">MVMVHPYETPCTVWCTTYETPCTVWCTTYETPCTVGAPPMRHPVQYGAPPIDTLYSRGTTYETPCTVGAPPMRHPVHSEPTYKDINDWGRRKMKEEEGKKMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSY5</accession>
    <name>A0A8J5JSY5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="88" mass="10191" checksum="7981FE4358C92989" modified="2022-05-25" version="1">MSQGNTPEKTLKSSQLPPTRTRPEILEELRGIRPRTRKKTPFLLVELDATGEGNQSEDVTEVAVPREDSEEIPVRRRQQRERRRPTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTV1</accession>
    <name>A0A8J5JTV1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Decapoda</taxon>
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            <taxon>Homarus</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028396">
        <property type="protein sequence ID" value="KAG7161988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="273" mass="31230" checksum="1B21FAA35FB57F5B" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDSSSDEQEATSDDIGRLFVSFKKSSPNNVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUA4</accession>
    <name>A0A8J5JUA4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cuticle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G003637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUA4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012539">
        <property type="entry name" value="Cuticle_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08140">
        <property type="entry name" value="Cuticle_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7164432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="343" mass="35900" checksum="497A16145EB7C548" modified="2022-05-25" version="1">MKATICMLAVGVSAQVGYSGIVSPTGANTQFSHEFAANIVLIGPSGIVTANGENRQLTAGEAQLHAGAHPVPVPHYVAQNFVYGPSGYITPTGQNVQYTHEQAANIVLTGPSVTCCRGAPVWECRGTVRQGPAPGRLGGVKHKLGGAVLLGVALRFSREKLLRKTKKKLLVKFDNLQTVAKMSRQALADSKKISCVQHPITGPGSRDHLAGAATICMLAVGVSAQVGYSGIVSPTGANTQFSHEFAANIVLIGPSGIVTANGENRQLTAGEAQLHAGAHPVPVPHYVAQNFVYGPSGYITPTGQNVQYTHEQAANIILTGPSGIVSRDGKNIQFHGYTTNTYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUD0</accession>
    <name>A0A8J5JUD0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Tstd3-L1</name>
        <name evidence="2" type="ORF">Hamer_G003506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUD0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="50"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="133" mass="14704" checksum="2D8A95A8650FB426" modified="2022-05-25" version="1" fragment="single">MNWVAQLPRIVLKPGCKYCVPVGTKASRYFSSSPTLPPDVAFEELQQNLTDEKVMLIDVRTSKELNRYGKIPKSKNIGLFILGTHLLLPEVEFESQLGFKKPALDEPVIVSCLAGVRARTAQLAMIGAGYKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUJ2</accession>
    <name>A0A8J5JUJ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUJ2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="207" mass="23372" checksum="32921427AB060CE2" modified="2022-05-25" version="1">MERFVHKAVATSPIQEGTHERRPAHHHTHPPSQSPGGKAAQPGAQAAAVQHPKGSSHVRFQTQTQTEYRTPNLEKPRERPDQDSSESETENTTNDEEAHTTEKFLLLTDQLSVDTKKHLSIKDIGVILDRLSSKIVDVEKLDREAEEEDCFNWTIKATIRGDTLRELGVVYNGHYYSISEHPGYGQKKEEEEEEEVAEAKDAEKEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUK8</accession>
    <name>A0A8J5JUK8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">THAP domain-containing protein 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Thap10-L</name>
        <name evidence="10" type="ORF">Hamer_G016320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUK8"/>
    <dbReference type="OrthoDB" id="6627680at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7161263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="371" mass="41946" checksum="14C69BF2E8E770C6" modified="2022-05-25" version="1">MGYTCVLSGCGKKSAPGVQLFQFPKDPATRQEWTLFVSKTRHANWKGPSYYSRLCSDHFVASDYKNYMEWNTGWTTKLILLPYQVPTRYPKGITSNLVSSSRHGIKIARHSNDSCSEHTSPTLVVSTAKTGRKIVRQPSDSYPEHTSPLTVSTPVLGRDPLAPSNPSTCKRPRGRPRGRPRGRTRGRPRGRPKSAFRRREISRIQQNMQSLDHTSIISDQGWQMFGVPVKEEKESRDETPEQILECDVVVKEEEVDCDEILSKEKLNEDVLEREKNLGSCSDMKEANLDSDRFREGLIVECDVIMREGDGLGLYVKESGENSDLHVIEETNDSCADTKVYKIVNERTMRRGITSDTEKSDPLSTFVQDGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUT3</accession>
    <name>A0A8J5JUT3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit beta</fullName>
            <ecNumber evidence="12">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Atp5f1b-L1</name>
        <name evidence="16" type="ORF">Hamer_G014020</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="12"/>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUT3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="14">
        <location>
            <begin position="160"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="283"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="15">
        <location>
            <begin position="506"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7161383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="611" mass="63685" checksum="9E6B0F2090AA2DEA" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVN8</accession>
    <name>A0A8J5JVN8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Longitudinals lacking protein-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lola-L8</name>
        <name evidence="4" type="ORF">Hamer_G008076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVN8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF98">
        <property type="entry name" value="PRE-LOLA-G, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7162520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="338" mass="37360" checksum="80AFBC529CC8E7E7" modified="2022-05-25" version="1" fragment="single">ERYTDATVACEGKFYPVHKLVLSTCSQYFEDMFEHTLGKHPVVLLQDVRRDELEALLSYMYAGIVSVAQRDLARLIKVAELLQIKGLAVPDEIPIDKKNTANDRSLSSERTSPPSKVSQGIESSDDRSSPHPKRRRREESGTPSRGGSSPTHAPDSPKAPLHTKDSNQMQESSKNCYSVQEQVLDDVHQRVEDLEQQSGGDRREHTEKSNTNRTAQQRNDHQVNQRLNHQPTTQDSSRNQFKDGGEEAIIIKEEAWEDPGDNQINSMNASMGYGPSVEDSSAGGMDGIQEDHTKLLLPKDYESQGHPGQLPQALPEVVVEALAGPSSMHEGGPGFLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWD9</accession>
    <name>A0A8J5JWD9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWD9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="68" mass="7676" checksum="252E9D4C13000315" modified="2022-05-25" version="1" fragment="single">MKTKRLVHDQRSDVLCLLQEVQPIFCDVPQPSPVVTHGVMLVDDVALVKQVPYCRSFLKIGILNDEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZC7</accession>
    <name>A0A8J5JZC7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZC7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="217" mass="24123" checksum="2D90E7431FF10676" modified="2022-05-25" version="1">MVVPGKALSAGDFYGVYTLDNACTCRLACWSAKRCVAVAAVPDTSANTVQCHLSEKGPINHTLTDTPDATYYFWEASVPNNFYGIMKDNYLYLVTNHQRTFTHGKELCAKIPGHRLATIKTARQFETVTAMLNANSMSWGSCWPVWVDLEKPGVLATPLQWGDGTLYGDGTVTQLATVVTERDYAAVYRLEDQNFDDKSDPDLYYILCQANPLGLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZV4</accession>
    <name>A0A8J5JZV4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 15 member 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Slc15a4-L</name>
        <name evidence="10" type="ORF">Hamer_G005153</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZV4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="597"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7164744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="653" mass="73454" checksum="B7869BF7327D7C58" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K082</accession>
    <name>A0A8J5K082_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U5 small nuclear ribonucleoprotein 40 kDa protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">WD repeat-containing protein 57</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SNRNP40-L</name>
        <name evidence="12" type="ORF">Hamer_G004699</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the pre-catalytic and catalytic spliceosome complexes. Component of the postcatalytic spliceosome P complex. Part of the U5 snRNP complex. Interacts with PRPF8. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Component of the minor spliceosome, which splices U12-type introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7164969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K082"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000375">
        <property type="term" value="P:RNA splicing, via transesterification reactions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000229">
        <property type="entry name" value="Small nuclear ribonucleoprotein U5 subunit 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="135"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="219"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7164969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="345" mass="38440" checksum="A71FEE12EC156FA4" modified="2022-05-25" version="1">MDGKRKADYMAVVIQAKKPRHEMVLHSGEKGLVQSGPPRTSSLMSPIMQLSGHQGDILCGKFHPEGEVVATAGMDRQILFWNIYGDCDNFGMLTGHTNAITDMHFSTDGTVLYTASADKTVMCWDTTSGTRVKKLKGHSSFVNCVHSARRGPSLVVSGGDDCTILIWDVRKKRPATTLQNTFQVTAVTFNDTSEQVISGGVDNDMKVWDLRKNGLLYRMRGHNDTVTGLSLSPDGSYVLSNAMDNTVRIWDVRPFAPQERCVKIFQGHQHNFENILLRCSWSPDGRRISAGSSDRHAYIWDTTTRHILYKLPGHNGSVNTVEFHPKEPIIMSVSNDKQIFLGEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0D6</accession>
    <name>A0A8J5K0D6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023275">
        <property type="protein sequence ID" value="KAG7165851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0D6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="313" mass="31754" checksum="568871A60A800EA4" modified="2022-05-25" version="1">MGEPLSDYIDYNVDDSYGEPTYSYAAPVAAYSPPATSYGAPSPSYGAPSQSYGAPAQTYGHTEYHTTYQAVPIPVAYDDYEEEESFGGKLAKGWDKAKEQFYKWEEETSKKIKDFFSYDSYDEEPEYIYYETPVHYAPSYGAPAPTYHAPAPTYHAPAPVVSGKGKGSFGGKGGFGGGGKGGFGGGGKGGFGGGIGGGKGGFGGGIGGGKGGFGGGIGGGKGGFRGGKGKGGGGLGSSIGKGKGGSGFHAPAPQPIVVQPQPYVPPQPSYGPPPTSYGAPPPTSYSVPAVPVHHGSGPVVPHDISHETSSYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0T2</accession>
    <name>A0A8J5K0T2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7162924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0T2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="157" mass="18189" checksum="0DAE551EA6348A48" modified="2022-05-25" version="1" fragment="single">LLDSALSYCDNLARVLYEAVKWRLGPFLEIPDIVAASFSDPRFKFEWLLSQDKKKKSFDTSKQFLWNLTPSVNHLNPRKVYKRGLAFFPPCLLQLKDPMVYWRDSPPKIAPPEAPGQRCFGLHSHFSTAKKVQLGVASFRELLLIKSNKYILYDQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1U2</accession>
    <name>A0A8J5K1U2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Octopamine receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Ocr-L</name>
        <name evidence="14" type="ORF">Hamer_G011859</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7165944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1U2"/>
    <dbReference type="OrthoDB" id="5955450at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15060">
        <property type="entry name" value="7tmA_tyramine_octopamine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF174">
        <property type="entry name" value="TYRAMINE_OCTOPAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="39"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="247"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7165944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="399" mass="45526" checksum="B65BCA9DE5E788B5" modified="2022-05-25" version="1">MSGLNFTSSSVDTDSNEWDLDNIFMVIILSVIIIFTIVGNVLVILSVFTYRPLRIVQNFFIVSLAVADLTVAVFVLPFNVAYSIIGKWIFGIHLCEMWLTCDIMCCTASILNLCAIALDRYWAITDPIIYAQKRTLKRVLIMIGLVWGLSFAISLPPLLGWNDWPDTFVEETPCALSEEKGFILYSSLGSFFCPLVFMSIMYIKIYKANLQRLRKQSNSCNGKTVADTPECDTVSLWKTLKTKLTGSRDRSLPFSSTGTPRQVETSFTDHKPTNQNSQQDNPQENSVSGPRHDSTNTFKKFLEDKHRISLTKERRLARTLAAIMGCFVVCWLPFFLTYVIMPFCPSCTKLNERHKNIVTWLGYCNSTINPVIYTIFNKDFKRSFISILKCRITCWRTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1U4</accession>
    <name>A0A8J5K1U4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SWI/SNF complex subunit SMARCC2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SMARCC2-L</name>
        <name evidence="11" type="ORF">Hamer_G023400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024717">
        <property type="protein sequence ID" value="KAG7165190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1U4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032448">
        <property type="entry name" value="SWIRM-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16498">
        <property type="entry name" value="SWIRM-assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="99"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="10">
        <location>
            <begin position="102"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="262"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="323"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7165190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="472" mass="52576" checksum="9FAAC966F0940BB0" modified="2022-05-25" version="1">MRVHAFLEQWGLINYQVDADARPTPMGPPPTSHFHVLADTPAGLQSINPPKVNQPSAAKHLMDFDKKTTDKKPDFSIGTDFGLKLDQYSKKTGALKNKSAASQAREWTEQETLLLLEALEMYKDDWNKVCEHVGTRTQDECILQFLRLPIEDPYLEDSEVGSGGSPNALGPLAYQPIPFSKSGNPIMSTVAFLASVVDPRIAASAAKAAMDEFCRIKDEVPAALLDSHIKNVADHAASNEGKVDPIAGLGKSGIAGTEPEGEEKKEGETESEKKDDAKKDGEKKDEEKKDEGDKEKKDEAMEVDKPDEKKTEEKKEGEEEDKKEDKADTKEEKKEEISPEEKKLDAERERLRKDASVQQAASAALGSAAVKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDRERESLELQRQQLLQERQQFHLEQLKAAEMRARQHALHQLTQGASPAHSPAPSMTQVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1Z8</accession>
    <name>A0A8J5K1Z8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ionotropic receptor 21a-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Ir21a-L5</name>
        <name evidence="11" type="ORF">Hamer_G002734</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1Z8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="122"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7163539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="392" mass="44057" checksum="01D06753AAF31089" modified="2022-05-25" version="1" fragment="single">LSFYGAEVNVTALPYPPYWDELEGPDGIKQYSGTDYFLLKSIADSLNFTINVVPTTSWAEVSQRVEERVSFMATVFHAMLPERLERYDYSWVYEYASLDFSMAQPGIKPQWQSLYYPLTDLVWAAVLLALLLTPLVLLLIIRVGEWRDGGDRVATGTVVQDVTGMLLGQNLPRRLPTVISSRVLVASWLMFALIFGSAYRGNLTAFLTLPKYPPRAETIQELVSTAHSKSDSQLFKRLGQLMHIVPSVNVGQQQAVERKQAHLDSGRYQQLKISKRFIGADGTPKLYLGRESIIPGQGAWPIPHDAPFGPVLDRCLMAAIEAGLYERWNDDLLRQAQMESRRRYKQQETEKETESDSSLRSLTITHLQGPFILFLLGLGLAGVSSIVELLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K200</accession>
    <name>A0A8J5K200_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain family 4 member F-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Clec4F-L4</name>
        <name evidence="3" type="ORF">Hamer_G024944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024418">
        <property type="protein sequence ID" value="KAG7165265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K200"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7165265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="127" mass="14593" checksum="B58EFFFD553E7CF0" modified="2022-05-25" version="1" fragment="single">FFLLERQCLLVNLEEKVSWADARTWCHNKGGDLAIPQDSRTLISLLNSFNVGEHLWLGGSDLATEGVWHDVSSKPINLRSSLWSESEPNDYGGNEDCVHLRYKEGEYGWNDVNCEYTYNFICEHQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2X4</accession>
    <name>A0A8J5K2X4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative REJ domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2X4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD/REJ-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="112" mass="12215" checksum="31FCB25749D00472" modified="2022-05-25" version="1" fragment="single">GVCTDYCSDELKYAWSISTLVNGVKSLITDGTSYMIGHDKPKVVIQKTLFIDHPTVLEFHIKQIISRLVDNEGGVGTMVLKINKPPGGGTCTLTPPPGRVFIEENTIIDPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K459</accession>
    <name>A0A8J5K459_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Glutamate-gated chloride channel-like 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">GluCa-L14</name>
        <name evidence="22" type="ORF">Hamer_G025051</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glutamate-gated chloride channel (TC 1.A.9.4) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025095">
        <property type="protein sequence ID" value="KAG7164559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K459"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008068">
        <property type="term" value="F:extracellularly glutamate-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18993">
        <property type="entry name" value="LGIC_ECD_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19062">
        <property type="entry name" value="LGIC_TM_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000024">
        <property type="entry name" value="Glutamate-gated chloride channel alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000022">
        <property type="entry name" value="glutamate-gated chloride channel isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044721">
        <property type="entry name" value="GluCl_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="20">
        <location>
            <begin position="75"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="21">
        <location>
            <begin position="326"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="21">
        <location>
            <begin position="390"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="469"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG7164559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="593" mass="66517" checksum="E79DC07578146682" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5Q3</accession>
    <name>A0A8J5K5Q3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Angiopoietin-related protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">AngptL1-L2</name>
        <name evidence="2" type="ORF">Hamer_G031294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014233">
        <property type="protein sequence ID" value="KAG7170415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5Q3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="35"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="267" mass="30921" checksum="D23DDF84FB03BCAF" modified="2022-05-25" version="1" fragment="single">KFLHQVRLGYDYINISSHKSNCRWSLFQDNINTCVVTTRPVRDCEDVYKAGGKESGVHTIYPKSSPAGVRVYCEVQEGQSWTVFLARHHQTPNENFTRSWQDYKKGFGDPEGEHWLGNENLHTLTGGETRYRLRVEATNLQGEQRYGEWRVFRVAPEDNRYRLTVEQYNSSSTLGDGLNYHNGESFTTVDRDHDTWSAGNCAVHHGGGGWWWWRWGWRWGCGLVNPTGPLHLSDLHQDPWKVMSWVFFIPGDGHWVKLSSVKMMVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6M6</accession>
    <name>A0A8J5K6M6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Ppid-L</name>
        <name evidence="10" type="ORF">Hamer_G023715</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010019101">
        <property type="protein sequence ID" value="KAG7168761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6M6"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000022">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5 8" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7168761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="371" mass="41085" checksum="FA6D1CF9186C7E08" modified="2022-05-25" version="1">MSAPLSGKPHVFLDVKIGEEIIGRIVLELFADTCPRTVENFRALCTGEKGIGKKGFPLHLKGCTFHRIIENFMIQGGDFTDHNGTGGESIYGDKFEDENLEHKHTSAGVLSMANAGPNTNGSQFFITLSDTPHLDGKHVVFGRVVKGLGVTNVLGKVKTDGDKPVERCEIYDCGELKSGDSFGIVDDDGTVDTYPQFPDDSDVNFEEATMDELAKVVNNIKDAGNTFFKKQEYNTAIKKYQKSLSYVNYIKEYNTSKRSDFSDADANTLDSLAVSCLLNHALCSSKLGWFDKAISDCSKALELDNTNPKAYFRRGQAYNLSNDTDAAKADLEKARELEPNDKGILKELDTVVKKIKAQREKEKKIYAKLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7Z3</accession>
    <name>A0A8J5K7Z3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IgGFc-binding protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FCGBP-L2</name>
        <name evidence="6" type="ORF">Hamer_G021156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012219">
        <property type="protein sequence ID" value="KAG7171405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7Z3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF402">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035293228" evidence="4">
        <location>
            <begin position="24"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="5">
        <location>
            <begin position="121"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="415"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7171405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="489" mass="56206" checksum="3F2F6F90EF433CDB" modified="2022-05-25" version="1" fragment="single">MEWITRGMSLSFLVLSLVSLSVQQHEYDCLTEPVGARCCCYGKDLFNHGEVVVSLPESCLQLVCQDTHIVAEYFNSPGDSHCCEFNGQVYPDGCVLTGQCLEVICRRGRWFLTGNYDECCAHCELTNDPHITTFDGYRYDWHGTCNYSVTQSDFSLDPHVGVFSDFEPCNAWASCLGHTTFRDNPNTIITMRVSSLFLPLVNGIPYPVPTSLSQVIVNGVPHPVLAYKSGSCVTFIGSCQLVVRHCSNRLDVIAHPAHMRQLDGLCGHFNGYQMDDFTSRQEVVHPLQYRPLAFPLSWLTDDQCEEKCKDECPELMGCEGEGTHDPCTLDHDGEEWRHYWKLCWKKLGNIVGKDVKRQHYIETCAFDLCMLNQNNMGEREEFRWLEALAENAHLAMAIPHFKGERQESDKRIHNYYDNGNYNNHNNFNNHNNHNNYNNHVNNHNNHNNHNHNNYNNHVNNHDHNNYNNHVNNHNNNNNYNKGPRQQPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K9P8</accession>
    <name>A0A8J5K9P8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Neither inactivation nor afterpotential protein C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ninaC-L</name>
        <name evidence="17" type="ORF">Hamer_G019706</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014926">
        <property type="protein sequence ID" value="KAG7169893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030832">
        <property type="term" value="P:regulation of actin filament length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000421">
        <property type="entry name" value="Serine/threonine-protein kinase PAK 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF2">
        <property type="entry name" value="NEITHER INACTIVATION NOR AFTERPOTENTIAL PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 12" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="16">
        <location>
            <begin position="342"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="806"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="12">
        <location>
            <begin position="859"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1146"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1331"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="809"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1350"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1406"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="435"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7169893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1443" mass="165280" checksum="157DA4E505875783" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KAE3</accession>
    <name>A0A8J5KAE3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013154">
        <property type="protein sequence ID" value="KAG7171027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KAE3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="160" mass="16798" checksum="E63B23189B9AA83A" modified="2022-05-25" version="1">MEGGVVVGSAVTRLDYYMYGAVQWTVLRRRSSSSSGGGGSSSGGSRIGVVSGSDGGRASGYSATEMGAKGGASGVGYVPRGKSKEGDDQVLCIYLGGYEERKRHVDDGAGNNRGGCSIPRDSVFIEATGRSQVAVRSREDDVLLKYSRRPCDWSREEGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KAM2</accession>
    <name>A0A8J5KAM2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PEX1-L</name>
        <name evidence="10" type="ORF">Hamer_G011660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="552"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="917"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7168970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1292" mass="144141" checksum="2643E2881CB68F93" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KCN1</accession>
    <name>A0A8J5KCN1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Erythroid differentiation-related factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EDRF1-L</name>
        <name evidence="4" type="ORF">Hamer_G010125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KCN1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056582">
        <property type="entry name" value="EDRF1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056583">
        <property type="entry name" value="EDRF1_TPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15000">
        <property type="entry name" value="ERYTHROID DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15000:SF1">
        <property type="entry name" value="ERYTHROID DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23788">
        <property type="entry name" value="EDRF1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23723">
        <property type="entry name" value="TPR_EDRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EDRF1 N-terminal" evidence="3">
        <location>
            <begin position="92"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="EDRF1 N-terminal" evidence="3">
        <location>
            <begin position="304"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="EDRF1 TPR repeats region" evidence="2">
        <location>
            <begin position="835"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7167739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1228" mass="138474" checksum="D615E4D68AF435BD" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KD36</accession>
    <name>A0A8J5KD36_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016029">
        <property type="protein sequence ID" value="KAG7169543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KD36"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22714" checksum="8A5BBA0B3F569025" modified="2022-05-25" version="1">MRNMQCCALARHQWTVATFVNAGLDAIIFGQVALRVAQLTFHLAERQRQFVHQLQNFIFQVRFSITLLDLVIMTTEKFCVPPTQLSTNDFQVRKGHQPVVQVGGESMHKSESSSSSEGDDKGHDVEDQLFQALSETRPHSAAVERMFSMGKDILRPKRSRMSDKHFEMLVFLWGNNTGNMLVVMKWLLQAMCPPTRVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK19</accession>
    <name>A0A8J5MK19_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045406">
        <property type="protein sequence ID" value="KAG7154087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MK19"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="229" mass="25245" checksum="ABFE5ED185101558" modified="2022-05-25" version="1" fragment="single">GGPQIEITYTAIEEAILQLLDPASIHGIPGDVESEEPINEEEREPTPRPSGARFTATGSCFREEFMFRPVQEKDDSITRILNEDIQEHDITVPIVHLEPEISAPTNIPGFSSSGTYEVETCSSSNTRQPIAATKEQRSRSSTPSATAVRSTVTGDYTDEMDSSPMPSTSSSGRRPRTSSARKDEDLLREMLRVQTQMRDSFLQLVAHTECIASAMLCIAKVMQSKNPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKK4</accession>
    <name>A0A8J5MKK4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G014989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044109">
        <property type="protein sequence ID" value="KAG7154640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKK4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="112" mass="12168" checksum="6FD262B6AD228459" modified="2022-05-25" version="1">MLVVLVTSSTVTLEDLTKTPVCTPTTQPTTARHPTKVSTLRARRILRRVVSPVGALGSTVVRYTGFMSTSVHSTLVPTFSRSREDAGTRLSTDEADIIVTQLAGHCWREVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKU6</accession>
    <name>A0A8J5MKU6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G029060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043387">
        <property type="protein sequence ID" value="KAG7154925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKU6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="86" mass="9703" checksum="2894FB8C669481CE" modified="2022-05-25" version="1">MAVGLVYVYPRRTFITKLLHMADEKGMKFSEPVAAFGVRTPCPEQDFTRLKQEYSNLQLVLVILGRGGDLYGEYDIALISGLYQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLZ8</accession>
    <name>A0A8J5MLZ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G028011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039716">
        <property type="protein sequence ID" value="KAG7156170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLZ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="119" mass="13341" checksum="0A1E8B8CCBD4EE8C" modified="2022-05-25" version="1">MRSGECIRRENNAATRVEYSYATLGHVRFHLLKLGGFVWVAWDPEGIGRRSRPAVAVREIGRTGFHVAEIKERHLPAEPQPAIKGTLGFDAHGPSARLLRRNKSSRLKSPLLPGWMCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MN80</accession>
    <name>A0A8J5MN80_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAP-Gly domain-containing linker protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Clip3-L</name>
        <name evidence="2" type="ORF">Hamer_G005901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MN80"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF93">
        <property type="entry name" value="RESTIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="1">
        <location>
            <begin position="105"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="1">
        <location>
            <begin position="215"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="401" mass="42863" checksum="3156E63A30ADAF66" modified="2022-05-25" version="1">MTALHYSAYFDVAPVLDLLLRDPQECIPTPDQYELVPDVQDVIAKLRSCLSPTASHVHMAAHAYTAHNSSSQGSSGKAVLKAMGLKLCDRVLISGVKTGTLRFVGTTEFATGLWAGVELETPTGRHNGTVKGVMYFRCAKNYGIFVPVNRLTKIPHVNGGRQGRSTSVSQRQRAKTMSHIHNTTRKIVVGDRVYVDMGMGSGSTRVVTGVVRYTGGVHFASSFWVGVELDVPRGTNDGSVNGTRYFTCRSQHGIFASPSRIIKISTEQNVDGSLDLCEPSTLRFSRHSLSSGHGSNTTINMISSGSLSLGYPAPISYSSHGPMSLGSSGTIMGVGSSSTINLDCNGAMTQNMNECCATCSSSCHLLDNQVYGSVKSAQSAKTAIYPPNTSMTSLNRSFSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPX4</accession>
    <name>A0A8J5MPX4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Inner centromere protein A-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033418">
        <property type="protein sequence ID" value="KAG7159349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPX4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="533" mass="59733" checksum="4AF9218089377A95" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQR9</accession>
    <name>A0A8J5MQR9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA topoisomerase 2-binding protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Topbp1-L2</name>
        <name evidence="4" type="ORF">Hamer_G021720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031508">
        <property type="protein sequence ID" value="KAG7160251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17731">
        <property type="entry name" value="BRCT_TopBP1_rpt2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17718">
        <property type="entry name" value="BRCT_TopBP1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17727">
        <property type="entry name" value="BRCT_TopBP1_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17728">
        <property type="entry name" value="BRCT_TopBP1_rpt8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000020">
        <property type="entry name" value="DNA topoisomerase II binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059215">
        <property type="entry name" value="BRCT2_TopBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049936">
        <property type="entry name" value="TopBP1_BRCT_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="106"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="202"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="354"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="515"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="607"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="870"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="1217"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="747"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="850"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="969"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1119"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1126"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7160251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1336" mass="150224" checksum="5E3E0960C5E7C017" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQU4</accession>
    <name>A0A8J5MQU4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">brn-L</name>
        <name evidence="11" type="ORF">Hamer_G001766</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQU4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000042">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF349">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE BRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7160493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="335" mass="40241" checksum="FA4491EE4447F468" modified="2022-05-25" version="1">MMYLTRRSKMYRRKCSVSWAWIYYTHWGTFHTLQPLIAQLKAGEDVAVKPVNEFYYSYTYLNVEKCEAKDSIRLMYVVKSALQNFDKRMGIRNSWGFESRFSDVEIRTVFLVGMKPDEPHLQKLLAKEVEEHKDIIQANFSDSYYNNTLKTMMGLHWTYCYCQKVKYFLFVDDDYYVSTRNMLRFLRDPANYPNYLENYVVSAVNEYKEYLYAGYVFENAHPIRWVFSKWYVSLDEYPYSEWPPYVTAGAYVLSRKSLEDLYFGSIYTNKFRFDDIFLGMAAKYASIKPFHHKEFYFYRKLYDKEGYKWVIASHGFDDPKELQEVWSEQRSAGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQW6</accession>
    <name>A0A8J5MQW6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7159997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQW6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="130" mass="13985" checksum="A747D870DB85E072" modified="2022-05-25" version="1">MGTPARSAAGGVKQSTGPSARALTQLYYGAASVHLLAALLPAPPPTTTTRHAAHPQRPLLLLPPTAHTTTSFSATHRPHYPPTLLPNVAHPQRRRPRRPHHHPLPPTHHAAHIVLATHRPKANPPTHIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR09</accession>
    <name>A0A8J5MR09_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030990">
        <property type="protein sequence ID" value="KAG7160685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR09"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="67" mass="7394" checksum="A10F6925693C38B9" modified="2022-05-25" version="1">MRKATDSQDEVNEINNSNNSDVEDDPASVGTLLQDPASNPRSDITQHNVLLSNSGSNFISDMLWTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR62</accession>
    <name>A0A8J5MR62_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamate receptor-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Glrk-L8</name>
        <name evidence="11" type="ORF">Hamer_G001838</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR62"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="130"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7160551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="418" mass="47258" checksum="1F8CE41A3E4C5173" modified="2022-05-25" version="1">MVQTLQEALEDPEIIRGLQHHPRTFRFTEEVRVVLTVVERPPHLYVKEQDDGSLSVSGPMANVLHVMASSLNFTYNEADIALAPYTRTEDRNKYLEFTDSLYSDVLQCVAGKGQPEIDPWGFLFPLDSVVWTALLASLVIAWLAMVVLGSNNNKKSVGRFTWITDLFLEHLRVALRQDLRLGQRRGSEMLLVLGWMVVTMMVMWSYSGNLVSLLAVRYISKPLQTLRNLLDSSVTLIMTRNDVFIDFLLTVKSGELQELGNLYKVGRVKYQLSKTFPDVMEKLVTKGHHVLFSPGLALDRLAANYFAKTGRCDFYKMRESFFPLTHCIVALKGNLLVRAMSYRVRAILESGLYDHWLMSSIPFSTVCRHAPSIITERESLAINNLWGMLVVLGAGLLLALVTFCLELYVNKRSGDGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRD4</accession>
    <name>A0A8J5MRD4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030714">
        <property type="protein sequence ID" value="KAG7160791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRD4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="80" mass="8381" checksum="25CEC6EEC4D6AB58" modified="2022-05-25" version="1">MCTEYSWQLCLSAYPEPCLQPPHGNQGGPEVAMIGSPITGNVLGIVSVTSQRNVLMATEDNSVDDGPRGLSGQPGNPPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTI7</accession>
    <name>A0A8J5MTI7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026415">
        <property type="protein sequence ID" value="KAG7163790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTI7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="745" mass="84682" checksum="3E6133D2D2C646EA" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUB8</accession>
    <name>A0A8J5MUB8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tigger transposable element-derived protein 1-like 77</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TIGD1-L77</name>
        <name evidence="4" type="ORF">Hamer_G004414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUB8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF26">
        <property type="entry name" value="TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7163294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="484" mass="54888" checksum="1C0AC7F0A82F5B3F" modified="2022-05-25" version="1">MGITDPKPFNASSGWLQKFKKRNKITNINIGGEEASADRVAAREFPPFLREIMEEGQYTDNQVFNMDESGLFWKKLPYKTFVVKNASKCRGRKLQKERITVLFTTNASGTCKLKLSVIHTACKPHAYKSMDMAKLNVHWLTARKAWMFSTLSLSWFDDFCSRCEEILLLLDNAPEHSPLLLDRHPNVKVVFLPPNTTSILQPMDQEFICNVEAAFSAKKFNLLNDYTNTKEELRNLSDTNTDRKSEDDENQQLAEQEVLLKQFWRTFNVKKAVDLLVEGWDQLSVATVRHAWRHVLQGIPGVRQSKSVTGEVQTVAVAMDLAREAAQSVTVAGFSETTNDDILEVIRDPHVTTDEMVDDDDVSEEAGGASSQEERRLSHSNVRGAIECNEKVKLLLSDDPDANRYEIFTTQLLQTMEPYIKVYHDNINTSCRQSITEFFARNPPQPAQASDSDRGRDSDDDFEGFVREALVSVDDTDEDSPEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW19</accession>
    <name>A0A8J5MW19_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zwei Ig domain protein zig-8-like 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">zig-8-L20</name>
        <name evidence="4" type="ORF">Hamer_G022688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023675">
        <property type="protein sequence ID" value="KAG7165771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW19"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="130"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="246"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7165771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="360" mass="39441" checksum="661DCA9DE2C35986" modified="2022-05-25" version="1">MGITQPLIADKHLQSNSFRPRGVYWTSDQERQVKVILSSVNLTFLCNNQVVVRGNDTTKPDKTTTGVEQSLSYSRQKEQQRQQMKGLASISLGQVKGLASMSDGQVKGLASMSDGPFISEEESDSVPDGPYFLKNPATLVTVRAGQAASLTCIVKQLGNRQVSWIRGRDLHVLSSGQVTFSSDSRISVSHVKDSWTLTIRYTQPRDAGSYSCQVNTQPLIASWYNLTVVEARANILGKETMYVQFGSTVTLECVIKEELVIPGLVLWYQDDRLVDRDSRRVKVVTQVANVTTSTLTVTTAAQQDSGNYSCWPSSGRPDSVLVHVIQGEPPAAMQHGNSAAWVSTLLLVPATLTSLLFLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWH4</accession>
    <name>A0A8J5MWH4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G005533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022531">
        <property type="protein sequence ID" value="KAG7166433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWH4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="190" mass="21548" checksum="ABD3922988A40644" modified="2022-05-25" version="1">MERKPSIETSQDDTVVSQFGKLIHGTKSDHVGCLEGLVPPDVNTDTPVTNVMILDGAAIVHLLQPGSAKIFSDYAMHVFLPYIESQLQKAFRVEVVWDEYLPHSIKAGTRQRRGKGVRRRVEAIGFIPRNWQEFLRLDENRSEPFSFLAVRVVSMSTEKRVISSHYATVLFTQHKDASGNHVTMKRQSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXE1</accession>
    <name>A0A8J5MXE1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zwei Ig domain protein zig-8-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">zig-8-L3</name>
        <name evidence="3" type="ORF">Hamer_G005585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022531">
        <property type="protein sequence ID" value="KAG7166474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXE1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000129">
        <property type="entry name" value="CLUMA_CG018772, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF6">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 7, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="441"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="545"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="802" mass="85551" checksum="287740960675963E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY61</accession>
    <name>A0A8J5MY61_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Venom allergen 5-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">VA5-L3</name>
        <name evidence="4" type="ORF">Hamer_G016877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020459">
        <property type="protein sequence ID" value="KAG7168233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY61"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035236499" evidence="2">
        <location>
            <begin position="26"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="181"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7168233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="375" mass="41554" checksum="8F0D93D9FCCEBAB8" modified="2022-05-25" version="1">MGGDRVWLRGVLAVMLVLVGGGGDARTTTTPHHPRQQLLQEKEITQQLALIDKLVGVMLDATECGDRNKVGPEQQENTTAASPQSTKDPQSTKDPQSTKDPQSTKDPQSTKDPQSTKDPQSTKDPQSTKDPQSTKDPQSTKDPPPTKDPSDCQYSEFSPTHTMLKTQNTECEIHKTGLSAEEKELILTLHNDLRAKVARGEETRGSPGPQPPAANMQQLVWNDELAQVAQAWASQCPNGHDSAKERAMCTRDYYVGQNIHYYWGFDENPNWKKAVHDWYEEVVDMPNSFAASFQLHKTKKIGHYTQVVWADTNEVGCGLVYYEVELKGKLFPESKIYVCNYGAAGNVRSRPMYAEGPAVSKCPGDVSSTYPDLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYD2</accession>
    <name>A0A8J5MYD2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Lytic polysaccharide mono-oxygenase cellulose-degrading-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G021770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021234">
        <property type="protein sequence ID" value="KAG7167887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYD2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21113">
        <property type="entry name" value="AGAP001705-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21113:SF6">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-4" evidence="1">
        <location>
            <begin position="132"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="360" mass="39910" checksum="6AE045A59D9AFABB" modified="2022-05-25" version="1">MAVFRVAQLVHLRYMAIFPRLAASPNHRWSPDGVPSPLGCCRSHREAQEAESYPPSRFKTPQEVQLCTSWRASDVTEQDFKTLALALQDQSVVDQDSANTSISHSTRLSVSLSHSFVSTHIITVVVGMCSGHARLIDPPSRASAWRFGFDTPIDYNDNEGSCGGFNHQYAVNDGKCGLCGDAWEEDPRPHEAGGLYATGTIVKEYTQGEVISVTVEVTSNHQGHFEFRICPNNNPDVEATQTCLNMHPLYQEAGGFEYWLPTTRTGNFVVNLNLPLDLTCTQCVLQVSPTPVNTPTTPIPMPIAMHYGHANTHVYIHAYNHVYAHAFTHAYTHAYTHAYTQANTHAYTHSYAHTHASTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYJ0</accession>
    <name>A0A8J5MYJ0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Oaz1-L</name>
        <name evidence="6" type="ORF">Hamer_G010259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with ODC1 and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ODC antizyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYJ0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7167854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="232" mass="25517" checksum="BBC86705BA1FC588" modified="2022-05-25" version="1">MLSDFKQHVVMEVINKSRESFGEHRGSCTWLTQQLASPTHDCGCAKCCASPHWIWALNIATHTVLRWLASTFTWAQGLGGGFDAPHAAYVSTSAEGSGVGKPSEPPVAGTRSKPVSGTEVVSAAQNGCVRLSFKFQLAEQTTVLWETVVVGRRLYLSIVHLPEGSKEAFVSLLEYAEEVLGCSHVLICFKKDRSDRAMLIRNFMFLGFVAIPPGHPMAPANNDHFYMLYEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N010</accession>
    <name>A0A8J5N010_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pogo transposable element-like 77</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Pogo-L77</name>
        <name evidence="1" type="ORF">Hamer_G030358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016608">
        <property type="protein sequence ID" value="KAG7169432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N010"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="95" mass="10749" checksum="FA73068DF29B1546" modified="2022-05-25" version="1">MRAPELDVLCDFVIKAWNDINVETVIKSFKKCGLSNSVDGMEDDMLWEDEDETEAEATSSDLEFDPYDEAAINVSQDVLEELMISDVDDVDFEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N164</accession>
    <name>A0A8J5N164_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative trichohyalin-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G013892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012946">
        <property type="protein sequence ID" value="KAG7171097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N164"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052270">
        <property type="entry name" value="CACF_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028">
        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7171097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="383" mass="46030" checksum="88521D91D6424056" modified="2022-05-25" version="1" fragment="single">MLGMNPWATTTAPTEELVLHPAHVTAFLSKELRKKAKEAEKATENARRRAYVVKERNYETYNHIKGKTAEGVEGGDKDDTLSSILVRAMERKTKRKEMDEAMKIKKLEDIKRKLEEEKRQCEEARRTQNEKLIEMRETFKLRVMREQRWRAKEARQAKHNRLADDFRKHKLLYNYFNRFKILVVMSRDNRDKAKNHYQVKIMRKALTQLIIHRDKEQHWRENLAANFYNVCVVHKLFNKWREHTAHGRAPTAHGRTPTAHGSVDRAKPEVRPLEDMRIRKEQLLRAEKHHRQRLLRQYLWTWRWVALDQFLQRRAHTDLATQHYQRKVLQRGIRRWRRYVQEKGTRRQQEVVATRLRFLVKGIIPDFSPSSSSSDDDDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1D6</accession>
    <name>A0A8J5N1D6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G013915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012946">
        <property type="protein sequence ID" value="KAG7171111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1D6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="214" mass="24293" checksum="24C6FAB125D7228F" modified="2022-05-25" version="1">MMKTRRKLRLFKTHLAPHQEMRGRGGDELKIAAIFLVIGGEYESDILGFRTKRRQLLAPSGTKNTRNGKVDVNEIINLLDVVNFCHGHGLQCGDFTCNTRLTSIIILYGQGLSHSETARLIDVLTHALALWIRRFEDTGATINCHPRCTTPEQERVMAAVIHTGRCATTVSIRKQHGIRFTPKTIRNRLYSMVLHGRIPANKLQLTELKMEKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N215</accession>
    <name>A0A8J5N215_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N215"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="121" mass="13488" checksum="C55A66A7968F32E3" modified="2022-05-25" version="1">MWLGTRGAGSGRGNTEDVHVRLVVNHLTLIQENLNAYFPESESEHLNSEHLNANMWVLNPFADVGVKTILELRTDYAKKNTLQNIRTHQGFLGYTAGYCRIQEVGRAGDNHVRADAIIISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3V3</accession>
    <name>A0A8J5N3V3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HTATIP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Htatip2-L</name>
        <name evidence="4" type="ORF">Hamer_G006932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer. Forms homodimers during oxidative stress. Interacts (via N-terminus) with elongation factor EEF1A1 (via middle-region); the interaction is direct and competes with EEF1A1 binding to guanyl-nucleotide exchange factor EEF1B2, thereby inhibiting GDP for GTP exchange and reactivation of EEF1A1. Interacts with nuclear transport receptors XPO4, IPO5/RANBP5, IPO7, IPO9 and KPNB1 as well as GCN1L1/GCN1 and LRPPRC probably through their HEAT repeats. Binds NCOA5/CIA.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3V3"/>
    <dbReference type="OrthoDB" id="430436at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05250">
        <property type="entry name" value="CC3_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="3">
        <location>
            <begin position="11"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7172707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="223" mass="24634" checksum="7E82E1515E40064D" modified="2022-05-25" version="1">MSEGMTALVLGGSGEIGKQLVRELVANAAFSRIVLVTRRQLDIQSEKVEQKIVDFEKLDDYKEAFGGAQVGFCCLGTTRGKAGAKGFIHVDRDYVSHAARLLKEGGCSHFHLVSSTGANKTSMFLYNKTKGEAEELVKELNFPRLSIYRPSLLLCDREESRPLEKVAQIVVRGFDWRNKISIGTDTVASAMISNTLEPQSPTKSEEPKVEILENTDILRLGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N441</accession>
    <name>A0A8J5N441_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Defense protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Dfp-L</name>
        <name evidence="3" type="ORF">Hamer_G017907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010216">
        <property type="protein sequence ID" value="KAG7172925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N441"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF45">
        <property type="entry name" value="REELIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035242349" evidence="1">
        <location>
            <begin position="28"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="2">
        <location>
            <begin position="18"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="168" mass="17292" checksum="E214C3277455B99E" modified="2022-05-25" version="1">MKFSTMAGATAEGVLVAVLCLVAGVAGRSTTVPAEACQSMMPSHGHNAQLSQPPYNLIVRGNTQAINSPVNVVLAGAGPRDMFRGFFVKAFDDATGRAIGSFTNAPKTIDCGGVATGAHHAGPSAKNSVTLTWQPPVGFTGSVSFMATVVQTMDTFWVGVVSKSVNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4Z5</accession>
    <name>A0A8J5N4Z5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SOSS complex subunit B1-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nabp2-b-L</name>
        <name evidence="3" type="ORF">Hamer_G020134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009549">
        <property type="protein sequence ID" value="KAG7173511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4Z5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070876">
        <property type="term" value="C:SOSS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000072">
        <property type="entry name" value="SOSS complex subunit B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051231">
        <property type="entry name" value="SOSS-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356">
        <property type="entry name" value="OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356:SF0">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT B HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7173511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="266" mass="28177" checksum="6E33897204AFB0E4" modified="2022-05-25" version="1">MCTLRLVWTDTFGEYKRSPGSERPTYEHPPIRTRNMDVQYTLIRELKPGMKNLKLVFIVLEIGRANMTKENHEVRSVKVADRSGCVNISLWDEPGQLLQPGDIVNLSKGYASFFKNCLTLYVAKGGDLQKVSEFCMQFSEQPNMSEPNPELAAATAASKQVGGGGGGGDSGSGSTRGSGSQGSSGNSSGTPVADPVRDPRLQKPNTNGGNIDPRANKGGGGGGSNVTASNGHHTSGGRHSGGNSNSSTNSSKSRNHAPTNRQNSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5Z8</accession>
    <name>A0A8J5N5Z8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007950">
        <property type="protein sequence ID" value="KAG7174095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5Z8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1218" mass="108751" checksum="E1A5A6F1CA5D1BFC" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6U5</accession>
    <name>A0A8J5N6U5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase from transposon BS-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RTase-L1</name>
        <name evidence="2" type="ORF">Hamer_G003049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6U5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33273">
        <property type="entry name" value="DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33273:SF4">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="300" mass="33966" checksum="AAFF2B754AD2148B" modified="2022-05-25" version="1" fragment="single">MELANLEELQLLLSNFAPICICLHDTALGAYDHPLPEVIRLFTLFNFPIHLQRTYTMCSIYLPPSTPIAREDLVSLIRQLPFPSLILGDFNGRHTLWGDTIVNPRGDLIASIIEEMDLGIFNTGDNTHYHVQTNTTTVIDLSLCSADSLMDFEWRVTDNLKGSDHYPILLSSSEVFPTPRVPCWRLDKVDWELYKKLVKVDRSIEESPSVDEAVDYIATLLGWNNDGSSVVAPQEVTEIFHSEFAGVSSMVARFSEFKWVSRVEESQTLYFGVGRDETYNIMFSMKEMRTALSLTGDTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7I8</accession>
    <name>A0A8J5N7I8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007499">
        <property type="protein sequence ID" value="KAG7174611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7I8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="79" mass="8593" checksum="B8D2FF6121A0F865" modified="2022-05-25" version="1">MAGAIVKGSMNPGSEGSSAEGKQPDPDIRSLPDLYAIHTREHRKTMTLNALLAKRSTSSKKNFDFVLILANSNSSEKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N825</accession>
    <name>A0A8J5N825_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose dehydrogenase [FAD quinone]-like 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Gld-L17</name>
        <name evidence="3" type="ORF">Hamer_G025516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005507">
        <property type="protein sequence ID" value="KAG7175565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N825"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF227">
        <property type="entry name" value="GLUCOSE DEHYDROGENASE [FAD, QUINONE]-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="386" mass="41859" checksum="9384213CECA3CBFE" modified="2022-05-25" version="1" fragment="single">MSLSFIRDTFLGVTTAAVLPVLRLLLINVINEAGQGNFELSGPLTPSYDFIIVGGGTAGCVLAGRLSEVAGWRVLLLEAGGPPPLETYVPAFQPFDFIPGYSEDWGYSTASRQPQGRVLGGGSTVNAMYHVRGNRRDFDQWAALGNPGWDYHSVLPYFIKAEDYRVSLPHTEAYHGRGGPIGVTQAPLTPFSRAFIQSGLDLGYSVIDYNGPEQLGFSPATFSTKDESDHQLPEVLYSRPPSDLTSISLTAPPSYSHEVLTVGARREVILSAGPVESPKLLMLSGVGPKDHLHKHKVKVVTDLPGVGHNVHDHTEVLGLSWTTVKGSTAADLLQTYNPISLQQYKTTRQGPLSTAPLSFTNAWVKVLQDGDPYWPYYKCSSMASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N933</accession>
    <name>A0A8J5N933_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stress protein DDR48-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">DDR48-L1</name>
        <name evidence="1" type="ORF">Hamer_G009017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N933"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="100" mass="11163" checksum="9291C0A68C8D2E1E" modified="2022-05-25" version="1">MSPVANNVTCGTWNNVTCGTLNNVTCGTWNNVTFGTRNNVTCGTWNNVTFGTRNNVTWGTWNNVTCGTRNNVTWGTWNNATWRLGVQNARTRIVSVYVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9G8</accession>
    <name>A0A8J5N9G8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Esterase E4-like1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Este-L1</name>
        <name evidence="7" type="ORF">Hamer_G016999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7176035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9G8"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035164057" evidence="5">
        <location>
            <begin position="26"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="29"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7176035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="617" mass="69839" checksum="C8ABEF735BFC73BC" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9I2</accession>
    <name>A0A8J5N9I2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Vesicle protein sorting 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">vps29-L</name>
        <name evidence="8" type="ORF">Hamer_G001432</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the Csubcomplex and the retriever subcomplex. Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos. Component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to snx17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. The recruitment of the retriever complex to the endosomal membrane involves Cand WASH complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the VPS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9I2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000015">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="46"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7175363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="219" mass="24473" checksum="361C4AFE703220CA" modified="2022-05-25" version="1" fragment="single">IEAYTVQFNNVHVVQCITPGDWREVREQLNLVIKTLYSHLPDVLIMLVLVLGDLHIPHRVGSLPAKFKKLLVPGRIQHILCTGNLCTKESYDYLKTLAADVHTSYPEQKVVTVGLFRIGMCHGHQVVPWGDPAALSLIARQLDADILISGHTHKFEAFEAESRFFINPGSATGSYSALEGEITPSFVLMDIQSSTVVTYVYQLVGDEVKVERIEYKKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA35</accession>
    <name>A0A8J5NA35_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WSC domain-containing protein 2-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Wscd2-L 4</name>
        <name evidence="4" type="ORF">Hamer_G020776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WSCD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004696">
        <property type="protein sequence ID" value="KAG7175708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA35"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF9">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="111"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7175708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="423" mass="47728" checksum="558F687B2659AC4C" modified="2022-05-25" version="1">MSLLTKALTTRGGGGGEGVTTILGVTAVVTVTVMVVHVSQSELGRLTTINNTMNDTSGDMNHVGKVDGVFTNKSQLISIVQLDYTRKSKILWPEDPQCSWMEVRFGVELKRAWLLSFPRSGNTWTRYLLEAATGLFTSSVYNSTHLRGLGYLGESEPPWRGTTFTVKTHSFESLIRHPHLPVVAIIRSPARAILSYWNLSNMKLAWRRFRGSVKDASYKTGGFHKFVRERLEKWKSTYVNALRNTTRLHLVYYEHLREAPLREVRAIMTFLGMKPSESRLACLARHLEGVAKGSQREMYPYTAWERASFQRAITQVDTLARLRGFPPLPDYRSLAHCPNGPLLCWCHSDLALPGTLRPGSEQCYTRWHSDGPQHHPDGYNRFRWLPLICLAAVMFAINMGAHPLPFILAAEYVPTNVRGQGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA97</accession>
    <name>A0A8J5NA97_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004459">
        <property type="protein sequence ID" value="KAG7175946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA97"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="256" mass="27878" checksum="4582DD0F7E3D4790" modified="2022-05-25" version="1">MLIDKGLKFDNEINYLRDRMGKRVNMMRAMTGPTKTWLLCAADAVNRLELKDTILSKGPDTMSPDYSTPAPWESPPAVFNILQTGTRKADCNPHELRQVTERNMKALTPHNSTVYYTDGSVEPTSTKAGAAFTIEGGNTSLWRTSDGCSTLQVELTAILGALRHASINSQQGVCQQQQRTLSLIVMEGEDVFVPPDDAGPGGPVDSVEEPAVAVSEAAEAEAAQAEGQAQESQSPWPHLDDYFGLKSRDKRNANIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAG5</accession>
    <name>A0A8J5NAG5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat and protein kinase domain-containing protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Ankk1-L2</name>
        <name evidence="5" type="ORF">Hamer_G009772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAG5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1148"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1150"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1191"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7175763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1203" mass="133858" checksum="3C6E417FFB3C5B5A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAH8</accession>
    <name>A0A8J5NAH8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Acetylcholine receptor subunit alpha 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Acha2-L</name>
        <name evidence="17" type="ORF">Hamer_G009919</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Synaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAH8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097060">
        <property type="term" value="C:synaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000001">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 14" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035339808" evidence="14">
        <location>
            <begin position="21"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="15">
        <location>
            <begin position="33"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="15">
        <location>
            <begin position="152"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="16">
        <location>
            <begin position="223"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="16">
        <location>
            <begin position="441"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7175884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="533" mass="59727" checksum="B1A1F9AED62E391D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAY2</accession>
    <name>A0A8J5NAY2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L22, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mRpL22-L</name>
        <name evidence="7" type="ORF">Hamer_G015499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAY2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7176680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="263" mass="30260" checksum="86C93E73B433A602" modified="2022-05-25" version="1">MAASISRILGLHTLESCASRVSVSLANKRSLTSVTAQPVPQSAGLLTVRENFERCNFHTSSAMCWERPHGPRNWLKYNERKFPPTPLGEEERPAVSNIDPLGTCTTLLLPLVVMRGVRFVCHLKKNIKYSPSKMWYVASLVRGLRIDDAINQLKFVHKKGSVAARETLEEARDLAVKDHNVEFPSNLWVSESFVGKGMVIRGFRRHARSRFGKVEYKYCHYFVTLEEGEPPEHYYPHRRPLTPQEMLQEWIDNQRQRTITRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBL9</accession>
    <name>A0A8J5NBL9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G015538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBL9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="236" mass="26676" checksum="B53B46EE730120FC" modified="2022-05-25" version="1" fragment="single">STNGCKCFFILRQNIAGLQPPLPSKHCDSTPPSANMRASTIQYTTQCKHESQVKLYSTVTVQYATTQCKHESQYSTPPSKHESQVKLYSTVQYSIPTQCKHESQVKLYSTVQYSTVCTVQYSIPISKNREPGKAVVQYSTVQYSTVQIPPSANMRASSTVQYTTQCKHESQVKLYSTVQYSTVQYTTQCKHESQVKLYSTAAGTQCKHESQVKLYSKYSTVQYSTVQYTNQCKHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBM3</accession>
    <name>A0A8J5NBM3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Ubc2-L</name>
        <name evidence="10" type="ORF">Hamer_G000228</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBM3"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23793">
        <property type="entry name" value="UBCc_UBE2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000003">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="78"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7177010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="224" mass="24010" checksum="18B333D50D31BF2B" modified="2022-05-25" version="1">MSAPPTGALGSDSVPVSPPLPPITTGPQTPTTSPVPSTGSAPITQSSSGTTRQSNSSRSSVVSEARSSNPKMSKALSTSAKRIQKELAEITLDPPPNCSAGPKGDNLYEWVSTILGPPGSVYEGGVFFLDIHFSAEYPFKPPKVLFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQFLQNREEHDRIARLWTKRYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBY5</accession>
    <name>A0A8J5NBY5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial import receptor subunit TOM20-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">tomm20-L</name>
        <name evidence="13" type="ORF">Hamer_G015409</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBY5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.10:FF:000001">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM20 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022422">
        <property type="entry name" value="MAS20_rcpt_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01989">
        <property type="entry name" value="EUOM20RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7176604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="176" mass="18957" checksum="2DE1CB9CD65F5397" modified="2022-05-25" version="1" fragment="single">SRSCAGVCCSSHAVQNLAINRGLSMTMISKGTLGICAGVAGALFLGYCIYFDQRRRSDPNFKKKLRERRRKTTKGGSGGSSSVTWPNLKDQEAVQKFFLAQVQAGEELLAQGEIESGVEHLSRAVAVCGQPQQLLQVLQQTLPPQVFQLLLHKLPAVGESILQAAGGSKVTEEDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NC67</accession>
    <name>A0A8J5NC67_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium/myo-inositol cotransporter 2-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Slc5A11-L3</name>
        <name evidence="8" type="ORF">Hamer_G008279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NC67"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005412">
        <property type="term" value="F:D-glucose:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819:SF195">
        <property type="entry name" value="SODIUM_GLUCOSE COTRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7177635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="352" mass="38881" checksum="813951E6D5C7CF0E" modified="2022-05-25" version="1">MGVEDGMQIKWPDILVLVLYFVFVLAVGLISSWKTKRGSVSGYFLASRKMHWIPVGALLFASNIGSGHFIGLAGSGAASGIGIGAFELNAIFVLMLLGWIFVPVYMSSGIYTMPEYLRERFGGQRIRVYLSCLALILSIFTKIPADLYAGALFIQQMLNKNSVEWMYLSILILLAIASIFTITGGLTAVIWTDFVQTILMVVGACILMGMSFHAVGGYENLVQDYFYAIPNRTRYSIDNSTNCGEPPSYAMNLFRSAKPGESDLPWPAIYEVGGYNRLVTDYFTAIPSKVTYDANNQTCPNSQPPPYALNLFRPLVGSDLPWPGILFGLTIGSIWYWCTDQVLYKGVVDAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCN7</accession>
    <name>A0A8J5NCN7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G000572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCN7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883:SF12">
        <property type="entry name" value="SEA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883">
        <property type="entry name" value="YIPPEE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="882" mass="107176" checksum="C72CC8F67451DCF2" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCV3</accession>
    <name>A0A8J5NCV3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ladderlectin-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Ladd-L2</name>
        <name evidence="7" type="ORF">Hamer_G016709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002318">
        <property type="protein sequence ID" value="KAG7177417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCV3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF1">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 11 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="153"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7177417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="266" mass="29302" checksum="CF8E30C112EFA1FD" modified="2022-05-25" version="1">MTADSPIVRHPTRSHSCLIPPQSYRASPHHSPILPHPRLSYPASPYHSPIMPHPTTALSHTLHGPQSGCQSVPRTKSVWTPASSSSLPRAPKSVLVVVMITFSADRMTSFFVILLIRSLWNPAGALLLGRVKNDSCPTSGYVTKTLTVSDKRIGRKAYRLVTSHLSHHKARLNCANMGASLALPRIDAVRRLYSSASVWIMVSDATVENTWENTDTGEDLSFFNFASRQPNGGTAENCVYIKLINGLWHDYNCGYGLWFVCEVPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ND48</accession>
    <name>A0A8J5ND48_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G025279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000630">
        <property type="protein sequence ID" value="KAG7178235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ND48"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="816"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="310"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="589"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7178235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1041" mass="117910" checksum="E9B85D8845C81BCA" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T2S1</accession>
    <name>A0A8J5T2S1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Catenin delta-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CTNND2-L</name>
        <name evidence="8" type="ORF">Hamer_G009578</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7172229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028435">
        <property type="entry name" value="Plakophilin/d_Catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372:SF27">
        <property type="entry name" value="ADHERENS JUNCTION PROTEIN P120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372">
        <property type="entry name" value="PLAKOPHILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="851"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="895"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="1154"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="654"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="747"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1038"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1075"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1302"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1356"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="762"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1043"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1359"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1419"/>
            <end position="1446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7172229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1461" mass="159286" checksum="90FBA948CE2D9B57" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T607</accession>
    <name>A0A8J5T607_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Moesin/ezrin/radixin homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Moe-L2</name>
        <name evidence="13" type="ORF">Hamer_G017852</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Microvillus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell projection</location>
            <location evidence="8">Rhabdomere</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010216">
        <property type="protein sequence ID" value="KAG7172876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T607"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098592">
        <property type="term" value="C:cytoplasmic side of apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042051">
        <property type="term" value="P:compound eye photoreceptor development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010669">
        <property type="term" value="P:epithelial structure maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007315">
        <property type="term" value="P:pole plasm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006403">
        <property type="term" value="P:RNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13194">
        <property type="entry name" value="FERM_C_ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17187">
        <property type="entry name" value="FERM_F1_ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000003">
        <property type="entry name" value="Radixin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000002">
        <property type="entry name" value="radixin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000013">
        <property type="entry name" value="radixin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.450:FF:000001">
        <property type="entry name" value="radixin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011259">
        <property type="entry name" value="ERM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041789">
        <property type="entry name" value="ERM_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046810">
        <property type="entry name" value="ERM_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008954">
        <property type="entry name" value="Moesin_tail_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00769">
        <property type="entry name" value="ERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20492">
        <property type="entry name" value="ERM_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002305">
        <property type="entry name" value="ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48678">
        <property type="entry name" value="Moesin tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="12">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="447"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="288"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)</name>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)</name>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR002305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7172876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="560" mass="66734" checksum="682FFF9E042A27DD" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TBZ7</accession>
    <name>A0A8J5TBZ7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007588">
        <property type="protein sequence ID" value="KAG7174569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TBZ7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="158" mass="17525" checksum="087CCD6D59C7A5B3" modified="2022-05-25" version="1">MTRPPSTSPPHNHEVLSVCEFWKKYNIKNAVDRIVEPWHKINVATVLHAWKPLFANSEVSEWSRADRGKRGEAVCGGNANEHSGDGAAVPAPRFSDVQVEDLQEIVGQHQQQPTTEEMLEEDEEQSEPQATQGDDVKPGEPTTCQLTELLTTIASLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TC20</accession>
    <name>A0A8J5TC20_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rap guanine nucleotide exchange factor 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RAPGEF3-L</name>
        <name evidence="9" type="ORF">Hamer_G024732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAPGEF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008907">
        <property type="protein sequence ID" value="KAG7173805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TC20"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000002">
        <property type="entry name" value="Rap guanine nucleotide exchange factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF327">
        <property type="entry name" value="EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="7">
        <location>
            <begin position="346"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="6">
        <location>
            <begin position="473"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="8">
        <location>
            <begin position="739"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="844"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7173805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1083" mass="122712" checksum="64B62BA4277DCDD0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TCR1</accession>
    <name>A0A8J5TCR1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007499">
        <property type="protein sequence ID" value="KAG7174674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TCR1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="176" mass="19213" checksum="9985C77BF610D16F" modified="2022-05-25" version="1">MLIYLYLPGASVCQVNRNITSGSESHTTGVSISQGDDFISCPGPHDPANHTACCYTSEDESEFGVEESQDGPRCCVPPPQPTGMFYINDQLAMIIALSVTTVCVILTIIIIVCCFWSRCPLYSACRIRYHQDDIIAYASKDEETAGLNDMPPEETKGVSIYSPNAVKVTLKNDVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TK98</accession>
    <name>A0A8J5TK98_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Multicrustacea</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="184" mass="20169" checksum="AE242EAB3DB0CD13" modified="2022-05-25" version="1">MSWPHLITSVRGGRGFLRKAESDIPGVMKTWMLLLPTTLVLIISLDVARSFECPESVKSDCLETQNKERVVVAHPTDCSKYCKLTVAVVLYQGKITNEPLDNVPRQGHPSRPCQSSSNCMNNYRADPPTPTQNAVKLHNTTSNCASTTPSDCTPPPSNHATTPSSNYLATTLLNCTETPRQTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKJ6</accession>
    <name>A0A8J5TKJ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007906">
        <property type="protein sequence ID" value="KAG7174123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKJ6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="253" mass="28254" checksum="1073DEF80FA376C9" modified="2022-05-25" version="1">MMEGAIIRDRQTETGRRVRAYTRIASERRYIVTDRQTGRQTDRQQTDRQTDRQTDGQTDRQADKQTDRSRQTDRQISVKSLGVLTRESVKSLGRAPALWAITQQSPHHTDTKTDDHPTVQRQASLQKISEVTTVIPEDSIIVYTDSSLQDTDAADCAFVGYSGIQQDGIMGAINYLLDEKRSGLVISDNLSGLESTTSPHNLANSACTLPIPDDVSTITPGRVKKLLKEAALQIINEERSERRGASVSVRHYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLI2</accession>
    <name>A0A8J5TLI2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pol-L15</name>
        <name evidence="5" type="ORF">Hamer_G004023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLI2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048270">
        <property type="entry name" value="PNMA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14893">
        <property type="entry name" value="PNMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Paraneoplastic antigen Ma-like C-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="4">
        <location>
            <begin position="412"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7178214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="702" mass="80126" checksum="737DA200CC13AB9E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TMC6</accession>
    <name>A0A8J5TMC6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TMC6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="183" mass="20708" checksum="641F8E30D6130838" modified="2022-05-25" version="1">MQPETIRPEIIQPETIRPEIIQPETIRPEIIQPETTTRPEILQPKTMRPEMVEAEEETGPAPHTESPTKHDIEPVTDRDLVAESMGISAPAGTPFTEPMAERDETLETIFDWLGETEEGEVTTLPPVDETEEEMLNMNDHSPTMMEIPETVTEMIMEEGYYMGRVLYGKSVGGKKNKEEEKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TV31</accession>
    <name>A0A8J5TV31_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G008294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TV31"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="214" mass="23103" checksum="E169D89C3D45FD50" modified="2022-05-25" version="1" fragment="single">TPHSIKLSADIDTDATPDLPISSLRASMEASTAEEDMEQLKFTPGMKSDIPNDSQVLSVGSQRVVSIDNGLQSTLETAADTVATAGDTMATFGTQLTSGENSIFWASLPTQCLVKSEFDGDCLVKSEFDGDCLVKSEFDGNNMEVSTGDIKAPKDHPARGKRRILIQDVQISHGKKTVPSHSMALRHFETCDSQNSDTPQEQMEKMSTTTNISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J7S3</accession>
    <name>A0A8J5J7S3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G009279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046319">
        <property type="protein sequence ID" value="KAG7153630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J7S3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7153630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="140" mass="13849" checksum="793970AADE8F7B02" modified="2022-05-25" version="1">MELSGSGSRYPKGLPSQSGLNKQPKGWGVVETDTVVDSFVVVVVCGAVVCGAVVCGAVVWLWCAVVVLWCVVLVCVWCCGAVCVVQVWCCSVVLWCVARCGAVVCGAVVGGAVVCGAVVGGAVVCGAVVCGAVVGGVVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGK2</accession>
    <name>A0A8J5JGK2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 2 subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 2 subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Eif2S2-L1</name>
        <name evidence="7" type="ORF">Hamer_G022933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040247">
        <property type="protein sequence ID" value="KAG7156026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGK2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="6">
        <location>
            <begin position="65"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7156026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="201" mass="23174" checksum="17E982A85E1D1E33" modified="2022-05-25" version="1">MSSIRKHFFENSLYSAVTIQDHLFYLSESGDGWVGSERDYTYDELLERAFNQLREKNPEMATGEKKKFVMKPPQVVRIGSKKTAFANFAEICRLLHRMPKHVLQFLLAELGTSGSIDGSNQLIIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDARLYFLQCEQCNSRCSVAPIKSGFQAVANKQQRQAIRASKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JH85</accession>
    <name>A0A8J5JH85_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent RNA helicase DDX18-like 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">ATP-dependent RNA helicase DDX18-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Ddx18-L1</name>
        <name evidence="2" type="synonym">Ddx18-L2</name>
        <name evidence="1" type="ORF">Hamer_G026148</name>
        <name evidence="2" type="ORF">Hamer_G026444</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035640">
        <property type="protein sequence ID" value="KAG7158112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010001193">
        <property type="protein sequence ID" value="KAG7177910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JH85"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="145" mass="16335" checksum="7DFA52687A9E4A61" modified="2022-05-25" version="1">MLFSATKDNKTNELVKLALKSEPMEVDVDADKINATVEDWNKVRYRVHSSVVKNCPCWWQWQCTLVSFVREIGFVHYLKAQKINVDSMDITWSKVANIQSQVAKCFLVPPLVDLGFQLAEDLSRGGGGATVEQETSGKDQNIQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JI30</accession>
    <name>A0A8J5JI30_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G022571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035183">
        <property type="protein sequence ID" value="KAG7158412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JI30"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="486" mass="52199" checksum="99E748E3C8F6DEE8" modified="2022-05-25" version="1">MILLRKLLFMDIGAPCRQSGLYTFWATMGAPEEDDNSVKLTKFKKMSSTPELDKYDDEDNNMNDDVDSESDTQGGEEDSSNTGDEGTTERHTESSKIDDRKESVQVAADSAPGVSEAATDGSRDRVVSPTVQDVETVPVVKCVDEAKSVGASVTIKTYSDAVKGVHNRHTTPSKDTKVGPLTDTTTDCSCWPATSCTDESVNIDKGVDCVDNVNIGAKIERESHCHAVCDSLEASHPTETCQSIGVSEGGGPQCDKDTRSDKTCQRDTHVTQPETLTDCHCSDDQDSLHLSDVEDATTTPPLDLSDLLRISEDVLSQGPGKTLNILQQGWACLGVPGSTTTTTTTTSLGDPSQLAVLKSRPEEKPDGDHKELFCTNIELEGHIGHHDNKAPKDTMFNVLLRGGGERRGTVGGGRRGRGRRRGRVGVSVEDEWIWYTLIFTPSDVGGDKRSLGRSIPVLTTAAASVIVKPTAIGILASIFVVFPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JI44</accession>
    <name>A0A8J5JI44_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JI44"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="113" mass="12869" checksum="272CFE25A05E4F6E" modified="2022-05-25" version="1">MGQLPLWMRPPPEGLSALFKMPEVLKGDPSLPPKEPHKVHVRSCDEEPVVDRWWTGGDSAGAPDEDDWRRMLWNWEDDGPRSAELKRPPPEVRELGLKRPPKCGVEEAPEVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJU1</accession>
    <name>A0A8J5JJU1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Als2-L</name>
        <name evidence="6" type="ORF">Hamer_G017578</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044465">
        <property type="protein sequence ID" value="KAG7154374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051984">
        <property type="entry name" value="Alsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057248">
        <property type="entry name" value="Alsin-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059093">
        <property type="entry name" value="HA_Alsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089">
        <property type="entry name" value="ALSIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089:SF2">
        <property type="entry name" value="ALSIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26202">
        <property type="entry name" value="HA_Alsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25383">
        <property type="entry name" value="PH_alsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="563"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="615"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="5">
        <location>
            <begin position="1452"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="622"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="770"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="770"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7154374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1603" mass="176482" checksum="C39F04BF3380BDD9" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKC6</accession>
    <name>A0A8J5JKC6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Myosin heavy chain, muscle-like 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Mhc-L17</name>
        <name evidence="17" type="ORF">Hamer_G005948</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031033">
        <property type="term" value="P:myosin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000036">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000008">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000019">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000021">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000025">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000009">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000010">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8 13" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin motor" evidence="16">
        <location>
            <begin position="1"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1994"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="935"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1426"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1701"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="2006"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7157499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2034" mass="233978" checksum="590DD49DE4AE0E6C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKL7</accession>
    <name>A0A8J5JKL7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative tail fiber protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7160002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKL7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="155" mass="17356" checksum="5FAA59AC1CD558A5" modified="2022-05-25" version="1">MPRRLPPMENPYLLGLKGSCGLEETLESRVGPGLTSSKINRKSKNRSTLSPNPRNHPPTELPGPENNLNNKSSSPRNHPPTELPWPENNLNNKSSSPRNHPPTELPGPENNLNNRSFSPRNHPPTELPWPENNLNNKSSSPRNHHQQNCLGQRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMS1</accession>
    <name>A0A8J5JMS1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G005748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMS1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="194" mass="22352" checksum="86BF83E294C1454D" modified="2022-05-25" version="1" fragment="single">LARQACFDELESEDTEDVLVSHTEELTNKDLQQLTEYMESADVEELLKSHCEDLSTEGLQKLVAAGEIEDAEDEEVQDAKPRELPTSVLSSILREVDKQLQILEDNDYNAERSRIAVRGVKYFLAPYEQLLCERRKTAKQQTLDVFISQPPRSRLKTLNHSHPLLELDVFFVPTMQPKLHLMMMILMMTMTTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNA0</accession>
    <name>A0A8J5JNA0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sn1-specific diacylglycerol lipase alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Dagla-L</name>
        <name evidence="1" type="ORF">Hamer_G007588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNA0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="113" mass="12845" checksum="BB1B3A4037E77170" modified="2022-05-25" version="1">MTTYKETQEQSSPCVQESLEDVQVTFSEDGTHRPQVPRHTEIPLYPPGRILYCFPKLPEDERLDGSTGEWEFTWGEMKGFSQILISPFMLRHHLPQIVLAALEDAAVQASDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNA1</accession>
    <name>A0A8J5JNA1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G014071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNA1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF1">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="279" mass="31241" checksum="BB1EC8E742E4094D" modified="2022-05-25" version="1" fragment="single">MKYICSLFSRLYKTNQACPPALSQMGDLRTGTKSVLVHCLEDLIPVQENVSSPIVQAIFLDGAAVVNMLRPDSARTFQDYANDIFMSSITFQLQHVARLGIIWDVYLPDSLKGDTHRKTGKSVKRRIEAPSTVPRNWQEFLSLDDNKTELFPLLARTAVGFETDKQVITKHNKHNADVLCSSSRVDVSGLDPCTHEEADTRILIHLEDAVKQCHKKMLIRTVDTNVEVLAVTAAQQISRALVPDRCAAMLMFHTFTGCDTVSIFGGRGKKTAWETWNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ37</accession>
    <name>A0A8J5JQ37_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G006426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7159014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQ37"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="81" mass="9585" checksum="568D21ABBE03BF19" modified="2022-05-25" version="1">MSVTWVTLSKKFDQYPENPYFWWISGMDSELDSNLTNNSLSTELKINIQPRNGWSRNPRPQMSEDENWNKGLDTNIVEILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ96</accession>
    <name>A0A8J5JQ96_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQ96"/>
    <dbReference type="OrthoDB" id="6344492at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035284658" evidence="1">
        <location>
            <begin position="17"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="135" mass="14596" checksum="DCB1DA0C1C20FFC4" modified="2022-05-25" version="1">MKFLVILLSYIALAWAQDEAECKCGAFVAESTDVREVVNLPDVEVKNCHDDEDCVSGCHAQWDELTNNGDLDTILDNGVSAGQTLCNALAEDGDLDFGPKEVYAYSSLCGGPWLTDGPASRHPLLCKDGRYVPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQD3</accession>
    <name>A0A8J5JQD3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Pzh1-L2</name>
        <name evidence="3" type="ORF">Hamer_G029825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010032623">
        <property type="protein sequence ID" value="KAG7159715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQD3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF496">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="2">
        <location>
            <begin position="572"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="604" mass="67208" checksum="4C54A26035A20F0D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JT06</accession>
    <name>A0A8J5JT06_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pol Retrovirus-related Pol polyprotein from transposon-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pol-L8</name>
        <name evidence="1" type="ORF">Hamer_G007565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JT06"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF29">
        <property type="entry name" value="PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="147" mass="16209" checksum="02BE20472555F167" modified="2022-05-25" version="1">MTYTSTFNDLVNLVVCEEFKKRIPFNIMGNLEDKGEKDLMKQAQLADRCELVHRFKGENKNPNIVKSPSGQNLGTKATITYLGHIVGQGRCRPKTVNVDAILNVAVSITCKSLMGFLGMAGYYRRYGKNFASVAAPLTSLTSGKVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTJ6</accession>
    <name>A0A8J5JTJ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025911">
        <property type="protein sequence ID" value="KAG7164057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTJ6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="67" mass="7583" checksum="8C75184C6E07453D" modified="2022-05-25" version="1">MTLLSSKTLTTRRSEGLCKRDKRQGRVGVEDNPGTMRFPSQKGLTVAPSSRLECIFRTSGRWQREAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTQ2</accession>
    <name>A0A8J5JTQ2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable arginine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Rars-L1</name>
        <name evidence="16" type="ORF">Hamer_G014451</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010026055">
        <property type="protein sequence ID" value="KAG7163992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTQ2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.70:FF:000002">
        <property type="entry name" value="arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000084">
        <property type="entry name" value="arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="15">
        <location>
            <begin position="107"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7163992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="532" mass="59986" checksum="14991410D6D47B02" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTY4</accession>
    <name>A0A8J5JTY4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTY4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="252" mass="27857" checksum="47E143155A7CA847" modified="2022-05-25" version="1">MNEESVSEASTSRQEVSFSDLQYHQAGMEVGGGGEAKGSVLTFPVNSTKKATRGQVGGEEGVLKETCRRSTKYGKRTNYSTRLSSLFKEHQRARDQYCLDITVGTRTDRRTDGPTHERTDARTDQHGRTDSRTDQHTDGPTHGRTNTRTNTQTDQYTDGPTHGRQHTDGPTHGRTNTRTDQHERTHTDGPTHGRTNTRTDQHTDGPIHGRTNTDGPTHGRTNTRTDQHTDGPTHGRTNTGISSPSTPPPSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JU74</accession>
    <name>A0A8J5JU74_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Gem-associated protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gemin2-L</name>
        <name evidence="9" type="ORF">Hamer_G003494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the core SMN complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the gemin-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JU74"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017364">
        <property type="entry name" value="GEMIN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038038">
        <property type="entry name" value="SMN_Gemin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7164326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="258" mass="28932" checksum="B1376C3FC578012A" modified="2022-05-25" version="1">MASDSYSSDDETLLSQALPTTKVPNNFDPSVPPASAEEYLQHVVWEARQCQDVVTVDVDRQKLKKPGTLKEVKVTAPHGYAPSPETQQELLTSFSNLRTHIANLRSSKQIPPSPVRFPSLKNREEWCKLCFGNSFQLALLKQANSDAAQPPLVEGQQPLLSIVLNIKQRGLRNLLEWHAQWLEVLGFSEAQGCWFYALLACLEKPLTPESCSQIRHIARICAKLRSSLESSDHPHLPHLNVIICIVARYFNQEDLADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUP8</accession>
    <name>A0A8J5JUP8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024964">
        <property type="protein sequence ID" value="KAG7164566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUP8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="274" mass="30430" checksum="8DB0C2DC08E6BF3E" modified="2022-05-25" version="1" fragment="single">MDRCRETGRSLGLPSLPPSLTNPETTLLALGAVLVVMTATEKVKMTVVLVNKESPMPNFDNPKGVKKRKYTLEKKQEMPKMIKNDARTCESALPPAPANQEEEMVDDLTPSTLHAPLHNHEVLSICEFWKKYDIKNAVDRVVEAWRKINIVTVLHAWKTSFANPEVSEAEQTKASGERQSVVATLMDTVEAARGDDDDGTTEDIEVLGDLLVEELPQDFEGFDDERKEQGGSSNQPFLPRNPSTSPVKHFTNSIKGHPFGNFAFHDAKSVPISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUQ5</accession>
    <name>A0A8J5JUQ5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Hat1-L1</name>
        <name evidence="7" type="ORF">Hamer_G003715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUQ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="6">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7164502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="112" mass="12860" checksum="D3E2FBAF5D97E068" modified="2022-05-25" version="1" fragment="single">IIYMNIVYYFAGVSGIAKSSLQYYVIDSNEALEFKLVRSPADIDDEESTFKPDMSHQVYGDSEQIFGYSGLRIKVYYSACRLTTYLTHTYTEKVDPEKFEGIEVSNLQNLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV97</accession>
    <name>A0A8J5JV97_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface A33 antigen-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">GPA33-L</name>
        <name evidence="2" type="ORF">Hamer_G007474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JV97"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="52"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="156" mass="17260" checksum="55A2407DAF50A6D4" modified="2022-05-25" version="1" fragment="single">MGSRAHFDLVSRPSGLVIDNLGTEDQGHYRCRVDFMSSPTRNYRLYLLVVVPPLRVSILSRSGQEVSGVIGPYPLGGTLTLNCQVTGGSPRPWVSWWHDGSKLDDMVEEVRGQVTINILTLPNLTRQHLYRVLTCRANNSNLTPPLAATVTLDLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVW1</accession>
    <name>A0A8J5JVW1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DDE superfamily endonuclease domain-containing protein 52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G004400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVW1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="152"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7163286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="233" mass="26677" checksum="299E98EA8B77B847" modified="2022-05-25" version="1">MPRRHRITSATDHERIIEAYRAEQDFLVVAAALGVQRTTAYSIVRVYQRENRVEAAHAGGRHKIIDNETLDLIVMLLEANPMMTLREIKEEVMDIFPTKPHFSEVTLSRYLEGELISLKMSRDSPAERNSPAVKEARHAYATWMLATGLQQQLVYIDETGFNLWTKRTYGRARRGERVHRTIGGQRGRNMTVIAAIAEHCGILYHEIHYGSVTKEVFSDFIASLAETQDPHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW13</accession>
    <name>A0A8J5JW13_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bardet-Biedl syndrome 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Bbs1-L</name>
        <name evidence="3" type="ORF">Hamer_G019431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024443">
        <property type="protein sequence ID" value="KAG7165240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW13"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005113">
        <property type="term" value="F:patched binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005119">
        <property type="term" value="F:smoothened binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028784">
        <property type="entry name" value="BBS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032728">
        <property type="entry name" value="BBS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056419">
        <property type="entry name" value="GAE_BBS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20870">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20870:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14779">
        <property type="entry name" value="BBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23304">
        <property type="entry name" value="GAE_BBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bardet-Biedl syndrome 1 N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Bardet-Biedl syndrome 1 protein GAE" evidence="2">
        <location>
            <begin position="457"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7165240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="564" mass="62950" checksum="6920FA3DB02575A1" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW44</accession>
    <name>A0A8J5JW44_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW44"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="73" mass="8180" checksum="AC693145F4D5C7D0" modified="2022-05-25" version="1">MEGTGGEFLVWWFLDPSPAGATRQRKKMEDGPSVPRSDSPENIVLRHRCGRASRCKLETGTETDSTVGVRERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWD5</accession>
    <name>A0A8J5JWD5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ethanolamine kinase</fullName>
            <ecNumber evidence="5">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ETNK1-L1</name>
        <name evidence="6" type="ORF">Hamer_G004609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWD5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7163458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="250" mass="28884" checksum="3A404A308F053CF3" modified="2022-05-25" version="1">MTPKLELTVDGSSVRGLQEGAKEIVQHVQPDWKQDKLEFKVLHRSGCCPPLYATFSNGLCYGFTQGSPISPDLVVQEPIWRAISQEMARYHKIKSCLTGLGCPVVFSHNDILLGNVIWNQETQKVGFIDYEYGGANFQPFDVANHFNEFAGVDVVDYNRYPSAEFQRQWLRSYLSHYQDIPEEEVKEHDVELWYVWVNKFALASHLFWGSWAMVQANYSSIDFDFLGYGITRVDEYFKRKNEFLSLTPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JX41</accession>
    <name>A0A8J5JX41_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP synthase mitochondrial F1 complex assembly factor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ATPaseF2-L</name>
        <name evidence="1" type="ORF">Hamer_G011076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JX41"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="255" mass="29228" checksum="C0E39717BF443EA0" modified="2022-05-25" version="1">MGGLRWAFGPQLLRQTSASVVPRRFLPEPRKRFYRNVTVAGTSDTYEVPNYGLALAIAHEWVAVKEKIHPSFMHLTGLANTVIDNPSYQTKWDVINKTLDYMDTDTVLFRDDRSDEFIQLQAKEWDPVLDWFNTKFEVNLKPCGGLLGANIPPPAREAIRRYLLSYNMWAANGFLYGVEAVKSVILTIAAAERKISAERAVTLSRLETNYQTSHWGAVEWAHDLEKYDLESRFSAALLFIHFNTWQTTVKQKAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXJ1</accession>
    <name>A0A8J5JXJ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox protein Dlx1a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dlx1a-L</name>
        <name evidence="8" type="ORF">Hamer_G004460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXJ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050460">
        <property type="entry name" value="Distal-less_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327:SF81">
        <property type="entry name" value="HOMEOTIC PROTEIN DISTAL-LESS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="87"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="89"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7163334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="141" mass="15628" checksum="AA4ACB82AD211D59" modified="2022-05-25" version="1">MILGARGRPAELLKSIPRRCRSRGAYEGILLQDSQRGTHCTSLEVINGVIQQGVGLLAAITLRCWSLSLLVTEKTEGGEVRVTAKGKKVRKPRTIYSSLQLQQLNKMFQRTQYLALPERAELAAKLGLTQTQTGKMVSYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYU1</accession>
    <name>A0A8J5JYU1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAST kinase domain-containing protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tbrg4-L</name>
        <name evidence="4" type="ORF">Hamer_G005267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7166965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYU1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23739">
        <property type="entry name" value="TBRG4-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013579">
        <property type="entry name" value="FAST_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010622">
        <property type="entry name" value="FAST_Leu-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF69">
        <property type="entry name" value="GH07286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06743">
        <property type="entry name" value="FAST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08368">
        <property type="entry name" value="FAST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RAP" evidence="3">
        <location>
            <begin position="536"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7166965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="602" mass="68125" checksum="B10951ED6A1F304B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZ59</accession>
    <name>A0A8J5JZ59_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LSM14 B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Lsm14b-L</name>
        <name evidence="8" type="ORF">Hamer_G010739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LSM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZ59"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="5">
        <location>
            <begin position="220"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="6">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="7">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="2">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="3">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7162084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="398" mass="42928" checksum="213E215D0F683C7F" modified="2022-05-25" version="1">MVRSFGTEDRPTEMPVPARDEVYEYIIFRGTDIKKIEVCDTPKQPTLPGGLHNDPAIVQHSAPAVPSSFQAAPFSRQSLGPIGGGLGLSYSAYGQSMTQQGIPGAGGFPMGSTSQPSELSTVAGGGGGGNLDQPSGTAPVAVQAPIGPPPQSGTHALHQTDILVGSRSSTPTTRKSPVSDAGVQVSPPPTREEKKKSPPQQQRQAQQERGQIFNQGSRQRQFQDRQLFEKDYDFEQANEEFEELRNQLAKTKITENGDKKDDSGHETAGGDDVDDQSTFYDKSKSFFDSISCEAIERSKGKSQRPDWRLERKINVETFGVSSARRGYYPRGRGGYYRGGYYRTYNYNQGYYRGGSGGYRGGRSSGGRGGIPNVNGMSQRGGGAGNSYASAVRNSTPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0E9</accession>
    <name>A0A8J5K0E9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ankyrin repeat domain-containing protein 13C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ankrd13c-L</name>
        <name evidence="10" type="ORF">Hamer_G005378</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0E9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000302">
        <property type="entry name" value="Ankyrin repeat containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055285">
        <property type="entry name" value="ANKRD13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF25">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11904">
        <property type="entry name" value="ANKRD13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Ankyrin repeat" evidence="9">
        <location>
            <begin position="164"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7167056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="257" mass="29239" checksum="2657F009BC391480" modified="2022-05-25" version="1" fragment="single">SPLTPVCEYVNMADDNNSYELHESVFNGDIRRVSALIRTCDVGKKDKHGNTPLHLAVMLGHKECIHLLLAHGAPVKVKNCNGWSPLAEAISFGDRQTISVLLRKLKLQSREHMETRRPDLVRALAQMGDFYMELKWDFQSWVPLVSRMLPSDICKIHKKGASIRLDTTLVDFNDMRWERGDISFLFTGSSKPSHSLTVLDNKLRVYQGVRHEETEAEIEDEVDILMSSDIVAAQMSTKQITFSRAQTGWIFRADKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0Q2</accession>
    <name>A0A8J5K0Q2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0Q2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="429" mass="48966" checksum="0FBDD6278F4F4646" modified="2022-05-25" version="1" fragment="single">MKHKISGHSRGMVVADVHVIPYVYCHHGAHDDDLAEGLAGRVCSLLIIIPHGPELFENTLYDRHSDFRETPIGTWGGLPALLVVILGSYDWCIPCLHYEAFLQHYSSTCEACTNVYNPVTAQPRVHSPHFIHNRCWFIHITHVDAIEKAQSTNNRRNYIDKELINDMIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDSSSDEQEATSDDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1Y0</accession>
    <name>A0A8J5K1Y0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Replication factor C subunit 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Rfc4-L</name>
        <name evidence="8" type="ORF">Hamer_G004818</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1Y0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000032">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7165058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="275" mass="30959" checksum="7713330251655D8F" modified="2022-05-25" version="1" fragment="single">RPKTVEDVAYQDEVVAVLKSTIKGADLPNLLFYGPPGTGKTSTILAAARQLFGDLFHQRVLELNASDERGIQVVREKVKNFAQTTVSSTRPDGKPCIPYKIIILDEADSMTNAAQAALRRTMEKQSRTTRFCLICNYVSRIIEPLTSRCSKFRFKPLAQDIMVKRLSYICEEENVKYEDGVLQDLIETSEGDLRRAITTLQSAARLRDGEEISQHDIMNQIHDHIIVNDLLSDLQKAAICERLAVCDHRLMDGGDEYVQVLDLSCIVMKQLCHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K213</accession>
    <name>A0A8J5K213_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K213"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="901"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1055" mass="116280" checksum="20792F2F36FE2F81" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2D7</accession>
    <name>A0A8J5K2D7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lachesin-like 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Lac-L13</name>
        <name evidence="7" type="ORF">Hamer_G023543</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024174">
        <property type="protein sequence ID" value="KAG7165535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2D7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000376">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="82"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="214"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7165535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="433" mass="47926" checksum="A4939724B0DD1CE0" modified="2022-05-25" version="1">MTTVPTFPSQVAWVQVDTQTILTIHKQVITRNPRIALLHNDHRTWHLKIKNVREIDRGWYMCQVNTDPMRSRQGYVDVVVPPDIIDRESSGDLTIREGQDVTLTCRAKGHPPPTIIWRREDNLDIIPDHGNTARGESHTESISRDVGEGETTAASVDIAGTSRLGVDDSTRVIEGDTLVLKKVSRLQMGSYLCIASNGIPPSISKRAHLRVQFPPMTGVPQQLEGAYVGQDLTIECHTEAYPKSINYWTNANGDMIVSGKRYEPILEESYYKTHMKLRIRDVTAEDFGTFRCVAKNSLGETDGAIKVYEIDPPKSHFNGGLEEQDDAETTEATGEPPATLPTHKKESKKYHSFHHTKGVNDIMDQQHLGKSSSFEGSHYTGPTTPQGLSPQESLDVVEHDAGEATCPVALLVAVVLVVIVTNTAFYASPPTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2I4</accession>
    <name>A0A8J5K2I4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">mys-L1</name>
        <name evidence="17" type="ORF">Hamer_G011122</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the integrin beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2I4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057073">
        <property type="entry name" value="EGF_integrin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF60">
        <property type="entry name" value="INTEGRIN BETA-PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23105">
        <property type="entry name" value="EGF_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52047">
        <property type="entry name" value="I_EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14 17" id="KW-0401">Integrin</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035209207" description="Integrin beta" evidence="15">
        <location>
            <begin position="19"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit VWA" evidence="16">
        <location>
            <begin position="27"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7166293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="606" mass="66631" checksum="2773881F169AC344" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2K9</accession>
    <name>A0A8J5K2K9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G021797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019050">
        <property type="protein sequence ID" value="KAG7168780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2K9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035290386" evidence="2">
        <location>
            <begin position="29"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7168780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="189" mass="20648" checksum="CC00D0C6BA5823FB" modified="2022-05-25" version="1">MSPSQQNTMKVWLMLGVVVLVGVGRSEGSLEAWGQGQDLPQEAQDSATSGFSISPGTVHQDVHSSVSPDVSSYSSTNLQTSSYYTDLTEPLQNPVNQLGHSRRGRSGSGSLGEEEPDNDLTRAFREDGKDAWTTFMLFQKVATALGRWSLLEYLPEGVEEVVDVARICLTSPQRRTIDLRAFENLDPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2P3</accession>
    <name>A0A8J5K2P3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020701">
        <property type="protein sequence ID" value="KAG7168091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2P3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="95" mass="10721" checksum="5CBA210D97D0D1E5" modified="2022-05-25" version="1">MLSWWQKRGCGNRQADILLAEAAQLLRRVLIEVKKNANPLPLAVNTQHFQKEQTPTAKKCINFILDVISQDSTNPNKRETSRSVTTCYSIPPKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4I9</accession>
    <name>A0A8J5K4I9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Rps7-L</name>
        <name evidence="5" type="ORF">Hamer_G018964</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014098">
        <property type="protein sequence ID" value="KAG7170477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4I9"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7170477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="194" mass="22333" checksum="9E4FE9494A512714" modified="2022-05-25" version="1">MPQFCNGKITKQTAEQPDEFETSIGQTLLDLEMNSELKAQLRELSITGAKQIDVSDKKCIAIFVPVPLLRAFQRVQQRLVRELEKKFSGKHVVVIAQRRILAKPTRKMKNPPKQKRPRSRTLTCVHDAILEDLVFPAEIVGKRIRVRLDGSRLIKVHLDKAQQTNIEHKVDTFAAVYKKLTGKEVNFEFRDTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K527</accession>
    <name>A0A8J5K527_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative EB module-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013550">
        <property type="protein sequence ID" value="KAG7170777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K527"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="189"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="321" mass="35042" checksum="FD097AD3994B8F55" modified="2022-05-25" version="1">MLYVGVVVGVVMVLGGTIALDEKLYQRYKNNAATGSIAVVKEFSSRLHCGLASMQLSGEGYNLKTTAEDKYECTIFSVVDGVLSDTDNNFYCGGGVCKEVGESCTEDWECFVLTEGATCVLGTCDCDLGYDPTDGVCEVGEDCEADVQCLATSNETKCDPTKKCTCAQYYKPNATGNGYYAAYGFVAYNGRWVYHLPGLRPISWEKAFTLCDDLFSTMFKPRDASEWGWMEQKTGSVLNTLAMFPINDRDQEGVLMWNNGTAVGGENYLKWSSGSPKASNTPIANCVGMVPSILFVSPEYLKFIECSKDNLLTSVFCEADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5C1</accession>
    <name>A0A8J5K5C1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Radical S-adenosyl methionine domain-containing protein 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Putative heme chaperone</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Rsad1-L</name>
        <name evidence="6" type="ORF">Hamer_G019421</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024443">
        <property type="protein sequence ID" value="KAG7165234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5C1"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="COPROPORPHYRINIGEN III OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932:SF5">
        <property type="entry name" value="RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01065">
        <property type="entry name" value="anaerobic_coproporphyrinogen-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="45"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7165234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="495" mass="56535" checksum="E3C4C0541A7B596F" modified="2022-05-25" version="1">MKILQHLWKYHQRGVIFADLRYLNTYSTEKFPSSEEKLSHAYLPKSYLNTGSVYVHWPYCRQRCSYCNFVKFIPHPNSHWTIQDNILEDAMVKELQHNLQHSHISSVQSVFFGGGTPSLARPHMVEKVLAAIEEVCHLEENAEITLEGNPTSLETKKLKDFRAVKGINRVSIGVQALDESSLRLLNRDHSIKEAMQCIHVAKQLFPGRMSIDLIFGRPAQTTQSWAQELEKVLSFCDDHISLYQLTVERGTKLFCQVKSGEVIMPSTDQMADLYEVAVSLLDSSGFTRYEVSNFARGYLAECVHNKSYWQGLQYIGVGPGAHSRVVPKTISENNSVDNLCISKFSRKETHFNNSRNNELHSLQNNNCLSKNDYNNYTVREARVNAADPANWLREVTLNGSGVRKITPQTMFDVICEYVASGLRTNTGITAETWNILLPHITLWEAFHESTVWLQENKLLQVSSERVKATRQGLNVLDSILPYLLNILEEKFTKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5I9</accession>
    <name>A0A8J5K5I9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015063">
        <property type="protein sequence ID" value="KAG7169861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5I9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="254" mass="28398" checksum="E6B4F6F5EF2F2127" modified="2022-05-25" version="1" fragment="single">KQCISHFPPQDIKGGCSTANADWPYFQILDQVVPLMRKEKIEKIPHSSLDHRDLDAPHDSLPSPLTTPIVPEQDPLSEASDPLSVTSVNTVMVSAQSSTVGDGKCKIEAVDGEPPRKRGRGRRAAQRARDRWWGAVEDDDMGSDSTGIAVRGELTTQQGTPKSSTVDNLDPSQMEVQTFHMLESCSSALAEIRETLRLHTERQETLMQVSFLDSGKFGNFLKESELFRMYFYLNDIMTLDLSYYSPPLRSICIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6C0</accession>
    <name>A0A8J5K6C0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">cAMP-dependent protein kinase catalytic subunit 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Pka-C1-L2</name>
        <name evidence="8" type="ORF">Hamer_G026845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019995">
        <property type="protein sequence ID" value="KAG7168581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6C0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="7">
        <location>
            <begin position="200"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7168581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="252" mass="29158" checksum="8A25F72AFD4F43CF" modified="2022-05-25" version="1">MVLLNVYISPTFQDNSNLYMVLEYVPGGEMFSHLRKIGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYLKVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYEKIVSGRVRFPGHFSSDLKDLLRNLLQVDLTKRYGNLKNAVNDIKNHKWFSSTDWIAVYQRKIEAPFIPKCKGPGDTSNFDDYEEEALRISSTEKCAKEFAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7X4</accession>
    <name>A0A8J5K7X4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase TRIM13-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Trim13-L1</name>
        <name evidence="6" type="ORF">Hamer_G022240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017535">
        <property type="protein sequence ID" value="KAG7169278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7X4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052667">
        <property type="entry name" value="E3_ubiquitin-ligase_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47156:SF10">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM-21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47156">
        <property type="entry name" value="PROTEIN CBG20824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7169278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="499" mass="55190" checksum="8D00EAF9DEDB6C62" modified="2022-05-25" version="1" fragment="single">MMDCGKPEECKVCLNNFDEIDRRPRILPCGHTFCSPCLADMIKNALFLCPSCRADHSALATTDVTELPINFTSEAFLKKLKEIQSKQPKAPKKLDQDKPRSFSKKLRTLVQEQKSNLTDLITNSDHQLSQLTVYRKHLSHMKNEHQQLQDDLFIIVGQNRKAMELIEQEDSSAEDIQTEGEEGKQQLETMLGCLDTVSSAQEVVTSIDDSDRYSVETEDWIQKCRELFPDINAIHTSVTVKATIKKAIKVFTTEMGAIAAPDPALEGATASPTTLMERVERLTGRVSLCGLNVDNLRNMSGAVKSLVESGRVFAVHQDQDNLRSAKITLKDGQLYLHTLLSQPTPTNAHTIQHSDIMDALDPSSTLAFLDLAWEGLAKGRVLVRLSPDTPLARQFVLLCTGQRGHTYANTKLLEVTNKGKTGECVHGGDYEKNDGEGGAPLLPVMKGKYQESANEGALFSWLDPVNPKSAQFTISTKAHNTPRINVYGKVESGLEVANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K9M5</accession>
    <name>A0A8J5K9M5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lachesin-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Lac-L6</name>
        <name evidence="2" type="ORF">Hamer_G013279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015640">
        <property type="protein sequence ID" value="KAG7169661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K9M5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="146"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="253"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="514" mass="56497" checksum="F0797BE721C71184" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KBK4</accession>
    <name>A0A8J5KBK4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein SNAI1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Snai1-L</name>
        <name evidence="10" type="ORF">Hamer_G012346</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KBK4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="768"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1064"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="565"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="650"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7170111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1148" mass="128852" checksum="7B9A2D0C0091D374" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KEF8</accession>
    <name>A0A8J5KEF8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Roundabout 2-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Robo2-L3</name>
        <name evidence="14" type="ORF">Hamer_G021189</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013493">
        <property type="protein sequence ID" value="KAG7170808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KEF8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000600">
        <property type="entry name" value="Contactin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000005">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="896"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="80"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="170"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="272"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="360"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="460"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="572"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="686"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="784"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="951"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1033"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="951"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1033"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1075"/>
            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7170808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1129" mass="122539" checksum="A904C916F9D91C90" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KG91</accession>
    <name>A0A8J5KG91_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G013488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KG91"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="83" mass="9392" checksum="0FCFAD35BD7D5ED9" modified="2022-05-25" version="1">MRQVARHARKAAMPAAHGQPRARALRRARVGVAHALSGGHEGSEKPQDPAGRRRHLAWWGSSSERRDLCAQLHYILREHCYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KGI0</accession>
    <name>A0A8J5KGI0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rhomboid-related protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RHBDL3-L</name>
        <name evidence="8" type="ORF">Hamer_G016128</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014436">
        <property type="protein sequence ID" value="KAG7170320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KGI0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051739">
        <property type="entry name" value="Rhomboid_IM_Serine_Proteases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840:SF8">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="7">
        <location>
            <begin position="195"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7170320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="396" mass="44849" checksum="641BFE927D9ABAD3" modified="2022-05-25" version="1">MTRVDSIEMDAGYKAVRRGDYWTTLMHLTFGSSRFGDSRFRVFADSRIEGLLVQGFLQPPLRGRNLQVAEEFWSRHDPSHSRSIPLTVIKERLLQTKEADDMPNGLAESSSKHSSARETFNRATLSVVPRGERTVEKRSYLQEYKCCPPALFMITASLIEIAVFVYYCIDMDVPGTPNGPPPVYSPLIYNPFKRFEAWRYLTYALIHSGYMHLVMQVFLGLLLELVHGWWRVGLIYMAGVLAGSLSHSISAPKMYVAGASGGVYAITYSHVGNLLMNWSEMEFRWIQLVLCLTLTIADVAYALWDSYGSSNPSNTGHMAHLGGAIAGMLVGINILRNLKRRRWEKFLWWVAFFVYLAMVVTGIVLNCVLPVPDFFPDNDYTEEASLKDLFLNSLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KJ00</accession>
    <name>A0A8J5KJ00_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017173">
        <property type="protein sequence ID" value="KAG7169359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KJ00"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035310714" evidence="1">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="95" mass="10597" checksum="5D4A1A42CBB9E0B6" modified="2022-05-25" version="1" fragment="single">MAGYLTYLTWVLLLALCYTPAPAHSENLGLSRGHGNRHVRQALEEASYFYDGGVDATNPSTILTNMRKGTEFYNTLSQLINSVTQFIWTDIVLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KJJ1</accession>
    <name>A0A8J5KJJ1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="5">PME-1</shortName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Ppme1-L</name>
        <name evidence="9" type="ORF">Hamer_G019608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Demethylates proteins that have been reversibly carboxymethylated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010016480">
        <property type="protein sequence ID" value="KAG7169464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KJJ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="248"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7169464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="350" mass="38261" checksum="AF168A2B6281883F" modified="2022-05-25" version="1">MSDIRRTLMKNSLPPMGPPGVPGLNRGGRGRGGMMGGRRDYTPTSWKKYWDSSEDVTLEGDIFRVYKRGTAGPLLLLLHGGGYSALTWSLFAEVYGRQQPPCVLIGHSMGGAIAVHTAYHGYVVGLAGLVVIDVVEGTAMDALSSMQSFLRGRPQNFNSLQNAIEWSVRSGQTRNVEAARVSMPGQVKNTETGCCGTCDVESSMDYSNQNQETGGTVRADVILEEGSDSDTAQANQPTPAPTIPNENKLPVKKYTWRINLGETEKFWSGWFHGLSSKFLASPPSKMLLLAGIDRLDTDLTVGQMQGKFQMQVLPQCGHAVQEDTPDRVAEVLATYLLRHRLTTPKADFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLZ0</accession>
    <name>A0A8J5MLZ0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLZ0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="107" mass="12235" checksum="7120BE76FD1D0100" modified="2022-05-25" version="1">MKGKCHKRPRKENNISDIDNMSPAIHPVEESPTFAIPTVMKYEIPKETEFHHAFEVLVSLELEHKNIKFSLKPNLVGDLILSPKTTTQPRSSARSPTSTGRRSRKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMG3</accession>
    <name>A0A8J5MMG3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MRPL54-L</name>
        <name evidence="8" type="ORF">Hamer_G023773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038733">
        <property type="protein sequence ID" value="KAG7156799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMG3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7156799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="194" mass="21678" checksum="A5CFEF495829E19C" modified="2022-05-25" version="1">MRYTITNTQYLVITREDGTVLTPVIIMNDKITAPGDPGYTAPGDPGYTAPEVDMAACGPGGSLLQGLCISLPSSYRQLFLPTCTKIQQMNYAKALGAGRKGKGKLGPTVEKVRLPVETDPEKLVNNVCGSHPVKENREDIILKDDSEYPEWLWTLRTGKPPPMNELDPNSKEYWKRIRTMAMKEKNLHKKIKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMN5</accession>
    <name>A0A8J5MMN5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Star-like 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">S-L15</name>
        <name evidence="3" type="ORF">Hamer_G024120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038351">
        <property type="protein sequence ID" value="KAG7156875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMN5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053202">
        <property type="entry name" value="EGF_Rcpt_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009:SF2">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase FkbM" evidence="2">
        <location>
            <begin position="167"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="267" mass="30374" checksum="835D71409DC8906F" modified="2022-05-25" version="1">MASLVYQCLKMKYGQLLCLCVLLISVWILTNKSGTTQRLNEIFITKTSMDLKGKAPQPERVLTDATYQGAAQDDPALVTYVRHLMKPPSTLRYNLTHPEKQHFSQYRQTQHADATYFHGKREGFFVEVGAVDGETLSNSLYLERNLGWSGLLIEVKRGTLGVLGRTFPDRGERIQAIPLYTMLLALNTTVIDFFSLDIEGGEMKVLMTIPWDKVKVGLLVVESNLIPEGRKFLVDYMTSKGYKFIGNRGIDSWFMLPELVNQYIKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMQ7</accession>
    <name>A0A8J5MMQ7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Tigger transposable element-derived protein 1-like 243</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TIGD1-L243</name>
        <name evidence="4" type="ORF">Hamer_G030225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038475">
        <property type="protein sequence ID" value="KAG7156847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMQ7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="58"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7156847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="204" mass="22639" checksum="52C3DF1E5AAAE6AD" modified="2022-05-25" version="1" fragment="single">GTSGVTSIYPRPAFPEHRHQPSRGQQSLIFNFCWWFITSTYITMPPKRPAAPSGSTPKRARRVLTLNEKNEVLKQLDSGMSYAAVGRHFGLNESSALSARLYDIDPSLDRSLKAKRAIENVMLPYIELQREMRSKKAQTTITNFFSRRVPAIAEPAGILQQEAEAADTSQQQDVEAAGTSQQQDAVPAHTPQEDADLDSSYSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMU2</accession>
    <name>A0A8J5MMU2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G010031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMU2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="9717" checksum="0C53CD596063E320" modified="2022-05-25" version="1">MAEDLYKKAKAICETNHIQEQRGPRHKQRKMEEYVVESSCGISSNLSNAELLKRNLYFPCLDRMINELGQQFIGVGTDLMKGIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMW8</accession>
    <name>A0A8J5MMW8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Palmitoleoyl-protein carboxylesterase NOTUM-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Notum-L</name>
        <name evidence="3" type="ORF">Hamer_G020296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pectinacetylesterase family. Notum subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038254">
        <property type="protein sequence ID" value="KAG7157012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMW8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004963">
        <property type="entry name" value="PAE/NOTUM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21562">
        <property type="entry name" value="NOTUM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21562:SF122">
        <property type="entry name" value="PALMITOLEOYL-PROTEIN CARBOXYLESTERASE NOTUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03283">
        <property type="entry name" value="PAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="425"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7157012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="605" mass="67712" checksum="A139D105865330E8" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNP9</accession>
    <name>A0A8J5MNP9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger MYND domain-containing protein 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ZMYND11-L</name>
        <name evidence="6" type="ORF">Hamer_G008749</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNP9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034243">
        <property type="term" value="P:regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20159">
        <property type="entry name" value="PWWP_BS69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047268">
        <property type="entry name" value="PWWP_BS69"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047269">
        <property type="entry name" value="ZMY11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46379">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46379:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="5">
        <location>
            <begin position="143"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7158134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="275" mass="32207" checksum="CA064B068D296FC9" modified="2022-05-25" version="1" fragment="single">QLPVNIMERVIPAPSQKPGVFLSDRAATSHQALIRSDQLSRVSASEPWRAQLLLHHQMDLNTVDQKTSDCRYKTVYDFEIDALTIVHNVVIYQGVHSSIADMARQMLRDCQYDLMELEQCKDCYRMSNEKSDKYWFCKPCRPPHQLVYAKQKGFPYWPAKVIRVENELYDVRFFGSQHQRAVIEKSHVRPISVNIHTLQVKRTSAWNKACEELKKHQEYLSMTNNHESDHRNIRTDSEARHKGDTLSPDQESRHAHRVQTQLLQTSPKKEIKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNR4</accession>
    <name>A0A8J5MNR4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G008913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNR4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035258396" evidence="2">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="134" mass="13392" checksum="18A8815A21EE7AD4" modified="2022-05-25" version="1">MKVLVAAFALVATLAVTGSAEPLPEADPGFHGGFGGFGGRSHGGFGGYGGHGGYRGKRSAEAEALADPEADPSAGHLNYGGYGGYGGFQGVGRQHHYGKRSADADPEPGHSRFGGFGGHGGGFGGFSRYGGYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQR7</accession>
    <name>A0A8J5MQR7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FYVE, RhoGEF and PH domain-containing protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FGD6-L</name>
        <name evidence="3" type="ORF">Hamer_G021657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031456">
        <property type="protein sequence ID" value="KAG7160279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQR7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF267">
        <property type="entry name" value="PROTEIN CBG10230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="45"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="246"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7160279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="336" mass="38351" checksum="98A09AEB8F2E2DA1" modified="2022-05-25" version="1">MKLLALQDRLSSSSSTSGDHDNTSSNTGSSNTRGPRYELVRPGRYLLKEGELLKLCRREMQPRYFILLSDVLLYTSFVTSGPGGALRLNCELTLEGMKVDTPTAEEFKNEFSVISTSRSFTLQASTAQERDAWIEALREAIEDNASRRSTFMQAKMPLYQQPSTLTLGKQKHQAARVCETCFEILQKDFEHKYEGSSTLEEHPGMRIRRVSSLKAQFKKGVRDSGRNRIRKRIPERLMEVCASDTSSQMCGYLRMMVRRSWRRGWFVLKDRVLYEYRAPQDVCALQSIPVLGYKVEAMERVKEVAEGVDTCLAFQLTHPNQQPLVFHADTPNLAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR80</accession>
    <name>A0A8J5MR80_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sushi repeat-containing protein SRPX2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Srpx2-L</name>
        <name evidence="8" type="ORF">Hamer_G007795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7161003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF560">
        <property type="entry name" value="SUSHI, VON WILLEBRAND FACTOR TYPE A, EGF AND PENTRAXIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="532"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="602"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="578"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="983"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1126"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1341"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="983"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1002"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1049"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1134"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7161003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1360" mass="151724" checksum="D01D60329184E47E" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MT81</accession>
    <name>A0A8J5MT81_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein Pegasus-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">IKZF5-L</name>
        <name evidence="10" type="ORF">Hamer_G008072</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MT81"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000630">
        <property type="entry name" value="Zinc finger protein 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056438">
        <property type="entry name" value="Znf-C2H2_CTCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23611">
        <property type="entry name" value="zf-C2H2_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7162516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="130" mass="15123" checksum="F19432CFF1A3C9FE" modified="2022-05-25" version="1">MEEEEIDGESQLMCDGTDRILSNRDKHHCPFCNYATVKKDHMKEHIRTHTGEKPFSCPHCPHRTAKNSHLLRHLRTHTTAPYSCTYCPFFTTLKANLRKHVCPEAPELRSNSKTDYEDEHSQHLHAQGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTY0</accession>
    <name>A0A8J5MTY0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phosphofructokinase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G002674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTY0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="74" mass="8643" checksum="E6ADA1D6E3AEB313" modified="2022-05-25" version="1">MELQLVDQLREKLEKAKLSRDDLQKVLPPSLFKRHRHEAPAYIPYSFQKQKLILLYIPTTNSDHAELSISDPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU50</accession>
    <name>A0A8J5MU50_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU50"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035156839" evidence="1">
        <location>
            <begin position="27"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="167" mass="18766" checksum="8FEC3D15949AE514" modified="2022-05-25" version="1" fragment="single">LTLLHSSDLWSCSLLTCSSVVGGVQASLLRANDGSSIAATQEVAVVFAKHVQVCLLWQLNPQFKWVSRVEESRTLYLGVGCGKTYNIMFLMKGTRTALLLTGDTSPGPDDIPFSMLRTFKLRHRPFYRNYITGSGETVPSQPHGRRLLCYLSRRLEKRVFTRWNTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVJ9</accession>
    <name>A0A8J5MVJ9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acylglycerol lipase</fullName>
            <ecNumber evidence="2">3.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Abhd8-L</name>
        <name evidence="10" type="ORF">Hamer_G004729</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids. Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:75539"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes glycerol monoesters of long-chain fatty acids.</text>
            <dbReference type="EC" id="3.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Late endosome membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome membrane</location>
            <topology evidence="4">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.23" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7164992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVJ9"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="709"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="609"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
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            <begin position="310"/>
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        </location>
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        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037797"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037874"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046308"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047662"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7164992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="959" mass="105006" checksum="3A38FED2C2B82414" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWX6</accession>
    <name>A0A8J5MWX6_HOMAM</name>
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        <submittedName>
            <fullName evidence="1">39S ribosomal protein L47-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MRPL47-L</name>
        <name evidence="1" type="ORF">Hamer_G005241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7166943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="269" mass="32017" checksum="512B7C616A2F60B7" modified="2022-05-25" version="1">MMAALRRPSSALTAALIKFSRLHITPRQINPSLLTPTTTNNYFKTLQRRAFIHTTGRVGALSEFFDGENNWGEAEVKVGRAWRLDELRIKSNEDLHKLWYVLLKEKNMLLTMEHAAKEEHQLFPNPERIDKVEESMTNLEEVVKERNRAYWLLETGETGERPSGMVVDPLGRRLRRKFVEHHIPVWMHHQSKENIHRGFAVKKFQRLMREKSFLEKRKYYRRVRNHVCMLMRRFPNMDLEKVQQQYPEVDVQALRKRKIARGHHSENQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MX65</accession>
    <name>A0A8J5MX65_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding protein with serine-rich domain 1-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnps1-b-L</name>
        <name evidence="9" type="ORF">Hamer_G013666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022272">
        <property type="protein sequence ID" value="KAG7166642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MX65"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:ASAP complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12365">
        <property type="entry name" value="RRM_RNPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034201">
        <property type="entry name" value="RNPS1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="90"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7166642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="313" mass="35321" checksum="010D635B5A169290" modified="2022-05-25" version="1">MIQVAKHGVGAGYRPLFSGRRVYTELPHRRYRSVCGRLLGKRSTFKAGPDKSRSQSHEKKTKPKKPSKSRSRSGSPRPRRKPRSPTPRPTRIHVGRLTRNINRDHLHEIFAVYGSVKSVDLPMYDMRNNSSLNRGYGYIDFEKPEDAENAMKHMDGGQIDGQEITAAPVLIPRQLPPRRRSPLPMPPRRGPPPRWGRSPPRYNICAPSRWGGLLVEVSSLEMSHKLKTLKCVAGATVSCSPHSSMNKIRGVVYSIQLLCYSEETLQQKFADQEVIKINESQKPTPSASCSQKEECLGNKRIHREESLEGILEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXR6</accession>
    <name>A0A8J5MXR6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Low-density lipoprotein receptor-related protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Lrp-L2</name>
        <name evidence="5" type="ORF">Hamer_G010231</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXR6"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035319465" evidence="3">
        <location>
            <begin position="25"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="166"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7167828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="329" mass="37212" checksum="63FEA6324A93F2FC" modified="2022-05-25" version="1">MSQFPSVAGVVLLLLLLACSCVTGEKCSTPEEVKCASHHKCIPLRYVCDNDQDCDDHSDEDLHLCRAWRNDCSRGEVRCKRQGESSCVSIPAYCRMQYPPCEGDLDLRICQMLHNKQLQSLDSVVLTDYGLGDSNLGITQQEKEEFLLAVNSTLQHPACPPLYTLLDGACLSVFYPGAVSWGEARGFCKVIGGDLLTLNNVSQYTALLTHLHHTRMTRDFWVGGRYVNHTQGWTWINHASINLGSPYWALRYEGTCQNRNVTSRKTGRTRLANGGTCYHYQQAPHHHPVGWCVALTYQHYYYMTDEDCILRKSPLCVYTHEDIQQLTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXV2</accession>
    <name>A0A8J5MXV2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Gnpnat-L</name>
        <name evidence="2" type="ORF">Hamer_G018373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7167948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXV2"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="177" mass="19570" checksum="3A5792E12FDF5B2E" modified="2022-05-25" version="1">MGAPDVQLPSVGPEEGEVTLYDPDILTKLDWSKVTHMKNGVTSATPGEGLLVRPLCKADYDRGFLQLLGQLTKIGDISREKFNERFEAMRSCPGHYYVTVIEDTQLGQIVGSATLACELKFIRDCAKVGIVTTITLLAGEVGCYKMGLDCKDEMKLFYRSLGYSSEKGNDNTMIIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXZ6</accession>
    <name>A0A8J5MXZ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromatin assembly factor 1 subunit B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Chaf1b-L</name>
        <name evidence="12" type="ORF">Hamer_G002649</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXZ6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="436"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7168560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="529" mass="58822" checksum="2F7AA857F9A40BB7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY30</accession>
    <name>A0A8J5MY30_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2 9">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Polr-L</name>
        <name evidence="12" type="ORF">Hamer_G017149</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 9"/>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000031">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="11">
        <location>
            <begin position="643"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="306"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="410"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7167239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1487" mass="169756" checksum="2BF658E62FF670E0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYC6</accession>
    <name>A0A8J5MYC6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nas-7-L</name>
        <name evidence="4" type="ORF">Hamer_G013062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYC6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF814">
        <property type="entry name" value="MEPRIN A SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035342769" description="Metalloendopeptidase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="119"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="163"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7167584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="364" mass="42026" checksum="A31B9CA40A233963" modified="2022-05-25" version="1">MREVWACMWVSLWAAAAAVEWADVGVLLSGVNTISSNDVDHPHLNVTSAEQRWWHDGSVVPRQEVATKDISNLKAQMRIKRRPYLRRDPIEMAGLLEGDILPAPTHTNSPNMKEAQEKNAVVDTGRLWPGGVVPYQFSPEFTLLPLERYLIRHVMADISASSCATFRERTSEPDFIKIIFDQQRCYSHIGRMGGVQPVSLGIFCVNWWDLSTVYHELFHTLGFYHEHNRPDRDSFIEIKWNNIAEGRIQNFIKRTQSSSELTDMPYDLTSVMHYSPYAFGKWSFLTPTIKSRRRGYGFHRPRKPSKIDYRKLNRLYSCQRNTKLLPSFTIHQRPTHMPDKIARQKSMVVSGVKLFNNCGKTTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZ01</accession>
    <name>A0A8J5MZ01_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Muscarinic acetylcholine receptor DM1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">mAChR-A-L2</name>
        <name evidence="13" type="ORF">Hamer_G027942</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7169520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000995">
        <property type="entry name" value="Musac_Ach_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF265">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR DM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00243">
        <property type="entry name" value="MUSCARINICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="39"/>
            <end position="109"/>
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    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
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            <begin position="306"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="201"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7169520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="478" mass="53046" checksum="FFB805C6E48CBD60" modified="2022-05-25" version="1" fragment="single">TIPDFHHHHNVLHHRSLVFPQVILIAVVAGFLSIATLLGNLMVMISFKIDKQLQTISNYFLFSLAVADITIGVVSMPLFTLYTLMGYWPLGSFVCDTWLALDYLASNASRDSHYWSLLSVTHTTGPSLSVTHTTGPSLSVTLTHYWSRPQRDSHYWSPPQRDSHYWSLPQRDSHYWSLLSRDSHTTGPALSVTHTIGPSFSVTPTTGPSLSVTPTTGPSLSRDPHYRSLPHVPTLLSVTHTPSARLSLPQRDLKLPQRDSHSFSVTLTTGPSLSVTHTPQRDSHSFSVTLTTGPSSAVTLTTGPSLSVTRPLTYRVKRTPRRAAFMIGSAWIAPLILWPPWIYSWPYIEGYRSVPTSECYIQFIETNEYVTFGTAIAAFYLPVTVMCGLYWRIWRRRRTTEGPHQPAGGKKGPDYIAVCCLTCVDSGVLPHLCRLRCVASPVDSGVLPHLCELGCCLTCVDADVLPHLCRLRCDASPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZG0</accession>
    <name>A0A8J5MZG0_HOMAM</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G021349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017879">
        <property type="protein sequence ID" value="KAG7169219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7169219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="105" mass="11286" checksum="94B1F0626C0A157A" modified="2022-05-25" version="1" fragment="single">LGCVLAGSLRSGAGHNQQQNAANSLPSASEVIVVFYAAIIVILLGTNMRSPKSSSSRPRRSRSRSRPRHQLVLDPRDGSVSTQHTQKKKKKRDSNVPQVGGADNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N000</accession>
    <name>A0A8J5N000_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014926">
        <property type="protein sequence ID" value="KAG7169909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N000"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="34"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="134" mass="14593" checksum="03C3EC5DBCE155AA" modified="2022-05-25" version="1">MEEVVRQVAEAVSRPSTRRRAAAAVVAAAVVLAARRAGERQNNNNTDSSNRSHHNSVTSHPPTTANNHLRALSTTDSSTSSPSNRRYSSSHDHSVNATLVSPQPMILVDHRRIIDQDGREAETMASLKQDMAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N174</accession>
    <name>A0A8J5N174_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Alcohol dehydrogenase transcription factor Myb/SANT-like-containing protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G019907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012835">
        <property type="protein sequence ID" value="KAG7171172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N174"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7171172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="90" mass="10802" checksum="F4B449045EFC0FDF" modified="2022-05-25" version="1">MFVLPSATDQGNIHWSREETMVLIEIYRQHPCLWNVKVDMYRDRDKRAAALRQITEDMNRSGTTVTTSDVKRKIESLRTQHRRELRKMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3F9</accession>
    <name>A0A8J5N3F9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G009708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3F9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="109" mass="10689" checksum="56761360A172080D" modified="2022-05-25" version="1">MRVILAVVGVCSAAPQFVAPPPGQIVFGVDANGCTVGPSGKVCPTGPIQFTSEAQGVPQVVEPAPPRPHAAAPTHHAQHQAVFTGLVGPSGVIGPSGLVGPSGPVAFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3R4</accession>
    <name>A0A8J5N3R4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Bardet-Biedl syndrome 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">bbs5-L</name>
        <name evidence="11" type="ORF">Hamer_G006942</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BBS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3R4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006606">
        <property type="entry name" value="BBL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030804">
        <property type="entry name" value="BBS5/fem-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014003">
        <property type="entry name" value="BBS5_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21351:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21351">
        <property type="entry name" value="BARDET-BIEDL SYNDROME PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07289">
        <property type="entry name" value="BBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010072">
        <property type="entry name" value="DUF1448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00683">
        <property type="entry name" value="DM16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBSome complex member BBS5 PH" evidence="10">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="BBSome complex member BBS5 PH" evidence="10">
        <location>
            <begin position="153"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7172716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="303" mass="34444" checksum="9EF69FAA074130D4" modified="2022-05-25" version="1">MLWEDRDVRFDITPQQMRVRSGERMIDKLESIEDTKGNSGDRGRLVITNLRLIWHSLTMPRVSLSVGFNCIINITTKTVNSKLRGLTEALYILTKANNTRFEFIFTNLIPGTPRLFTSVNGVYKAYTSSKMYRELKLRGAIIQNKQLRILPQEQIFSRVNGVWNLSSDQGNLGTFIITNVRLVWFANMNELFNISLPYLQIASVKVRESKFGMALVVESSEASGGYVLGFRIDPVEKLHEVHKEISALYSVYSQCPVFGVEFVLQDKFLLDLGGYNMNTIPRAFLLVSAGQVGKYCIVSLQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3U3</accession>
    <name>A0A8J5N3U3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G006808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3U3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="32083" checksum="A75FB0C768F7A83C" modified="2022-05-25" version="1">MGGQHNSSWGDVMQGGVSCDARRGDVMQGGVSCDARRGDVMQGGRVSCDARRVRCDARRGDVMQGGVSCDARRGDDARKGDLGVLVSPDLRPRKQCINVRNKANRVLGFISRSVSNKSAEVLLQLYLALVRPHLDYAVQFWCPYYRMDINSLESVQRRMTKMIPGLRNLPYQDRLKKLNLHSLKRRRVRGDMIEVFKWVKGINEGDIDKVLIIYEQDRTRSNGFKLDKFRFRREIGRNWFTNRVVDEWNKLSNFVVSTGTLESFKRRLDRFMDDREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4X8</accession>
    <name>A0A8J5N4X8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit J-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Eif3j-L</name>
        <name evidence="6" type="ORF">Hamer_G022676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010089">
        <property type="protein sequence ID" value="KAG7173322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4X8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7173322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="234" mass="26343" checksum="C7FEA15DB3D13744" modified="2022-05-25" version="1">MSDVEWDADDFVPPTAAAARPTDKWDGEDEDDIKDNWDDEEEDKEKTATDSTAAPVKKKKKKLTDIIAEKEARQLEELEKRKKEAEEKAKLQTAEGKLAEKMRLQKIQEDSDLQLANELLGSTSSITEEDNKMLDDIDLSTSSGLESFRKALTSKIRISERLEKRPFFVTFVEDICRDLCQNLINSIYNEKVKAGKPKSKKKAGGKAKLNVGQGAIADDLGNDFGGYNEYDDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5J1</accession>
    <name>A0A8J5N5J1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uroporphyrinogen-III synthase</fullName>
            <ecNumber evidence="3">4.2.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Hydroxymethylbilane hydrolyase [cyclizing]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Uroporphyrinogen-III cosynthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">UROS-L</name>
        <name evidence="13" type="ORF">Hamer_G018134</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>hydroxymethylbilane = uroporphyrinogen III + H2O</text>
            <dbReference type="Rhea" id="RHEA:18965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="EC" id="4.2.1.75"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uroporphyrinogen-III synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010008733">
        <property type="protein sequence ID" value="KAG7173856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5J1"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006785">
        <property type="term" value="P:heme B biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10090:FF:000003">
        <property type="entry name" value="uroporphyrinogen-III synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="12">
        <location>
            <begin position="16"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7173856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="252" mass="27526" checksum="5F9F017BA11C8894" modified="2022-05-25" version="1">MSTVWLFKSCEESNSQYISILTASGFSPVHVPVLSFQFCNQVPLKNALQIPQNHSGIIFTSQRAVEAVAEIYSTLSVSCHHTWSEKKIFVIGEATGSAVQKLLKLSYTGQESGNAQQLAPIIIKETEAFDKPLLYPCGNLGRDELPKLLVKHDRDFRALTVYETSQHPQLKSVIQKLISTGQLPTYMVFFSPSGVNFTLSILKSLSVDITGVKMVAIGPTTNTALVQQNIPVSGICPSPTPEGLLHVLKSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N642</accession>
    <name>A0A8J5N642_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008839">
        <property type="protein sequence ID" value="KAG7173817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N642"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="169" mass="18609" checksum="BFE4697572F21AD4" modified="2022-05-25" version="1">MSLLVVCLGFCLKKRQQAGAKNRFSLQQNTNETSVKHHSSAGSSSCSIHMGNTSGGLPRSCNPPSRPSLPPPCVPPPLSTSQGKPQLQLPPGVTEGGVQHKDNVKRGVTDENDYCNAFFDLDAGNQLEKEKEEGMKKTREWEKEEGEGNLFNYKSDNSLCKRFNENEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6K4</accession>
    <name>A0A8J5N6K4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007712">
        <property type="protein sequence ID" value="KAG7174148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6K4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="251" mass="28839" checksum="E5D3527D85D690F9" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTMAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6R3</accession>
    <name>A0A8J5N6R3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">STE20-like serine/threonine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Ste20-L</name>
        <name evidence="7" type="ORF">Hamer_G015770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007499">
        <property type="protein sequence ID" value="KAG7174635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6R3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022165">
        <property type="entry name" value="PKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051585">
        <property type="entry name" value="STE20_Ser/Thr_Kinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46538">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46538:SF3">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12474">
        <property type="entry name" value="PKK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="593"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="732"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1146"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1209"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="924"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1092"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="295"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="644"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="743"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <end position="779"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1151"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7174635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1248" mass="138724" checksum="A072D099D61E96B6" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7W2</accession>
    <name>A0A8J5N7W2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-beta-hydroxybutyrate dehydrogenase-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Bdh1-L1</name>
        <name evidence="1" type="ORF">Hamer_G001502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7W2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="201" mass="23110" checksum="0C86632137A88DBC" modified="2022-05-25" version="1">MRCVVSPLMMVRNVKSHLHLRHDVQFPARGRVVTISSGLARMAVPMRSAYVLSKYAVEGFCDVLRCSNLQVFKSTGVQIHRYEMRSWGVKVSIIEPGNYIAGTNIFTESLIQEHGRKMWEAMSEEVKADYGKDHFQARIDLMRQYSKAGNTDISPVINAFTEGLTQKYPQARYCPMDLYFKTRLFVATHLPEFVYEKLYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N917</accession>
    <name>A0A8J5N917_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Carboxypeptidase B-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Cpb1-L5</name>
        <name evidence="16" type="ORF">Hamer_G015260</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Extracellular metalloprotease that contributes to pathogenicity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7175044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N917"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 16" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0843">Virulence</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase M14" evidence="15">
        <location>
            <begin position="98"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7175044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="362" mass="40420" checksum="57DE4DB197FD45F0" modified="2022-05-25" version="1">MARAQVLRVAPEEAAQVHYLKALHLQDLYDFWTEPRVVGSPVDIMAPAFQLPVLKKTLTQVGLKFTTMISDVGGLVAQEKAARDAARASAPGTMDWTSYHEYDEIMGWMDTVAKDHPDVCTVENVGKSYQQHDMKLLKLGKGVNKPIIFLEGGLEGREWISPAVLTYIIDQLVTKKETYDDLLSNVNFYFMPIVNPDGYYYTYTTVGASDDPCSEEYAGSEPFSEVEMRNVRDEIIKYSDYIDAYLSFHSYSQLWSSPWCWTTDLPDDWTDLDDLAHSIVEAVTAVHGEVYETGSCALSGPASGGSADWAKAVVDAKYSYTIELRDKGEFGFLLPEDQIIPTGEETMAGVLVLANFIKDNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N930</accession>
    <name>A0A8J5N930_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G015279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7175059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N930"/>
    <dbReference type="OrthoDB" id="6367655at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="445" mass="49636" checksum="7DE9475549308467" modified="2022-05-25" version="1">MTIMKQAFVKKKDQWCWVVVMTATLLTLLRLYHPATHAHSPNPLHYSQEAAEVTSWRLNSSRFRVQLPDTCECRSMFTVGACGLEGVAEMRAGDAAWVRAVKGLGIARTQLDETMMPHLATLARYMPQVFTANVTSATAASSHVKIEADPHLTRAATSLPFLPCEVHLYTPAEVLTCTRRYLAHTGAPLRIAFVGDSRVRNTMQQMIRGTLHHLQYRLEGDTHAMNDTLGFLDSKAKVNIPVVGDGLHLRLHWSTFLHRQRQPDDVSRQGARDLLEAWASGTPGPQDGPVPDIIYVTSGLWDTSMSSGDEAVSDFMYTLQVMTPILNKLARRSRVLWHVHGPIKAWLAIREVPNGALDMINRAAWAKLGHGGVWLWDSHTVMMLRQHTECRALHQAGLAPLTPTSWGCRDFQHAGKDVEDGATNMLWNLACNALLHLPQHHCCAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9S2</accession>
    <name>A0A8J5N9S2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose glycohydrolase MACROD1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Macrod1-L</name>
        <name evidence="2" type="ORF">Hamer_G015353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9S2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140293">
        <property type="term" value="F:ADP-ribosylglutamate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140291">
        <property type="term" value="P:peptidyl-glutamate ADP-deribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042278">
        <property type="term" value="P:purine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="126"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="304" mass="33729" checksum="152324CB5D7C716D" modified="2022-05-25" version="1">MTLFITCPYYILSRPLVRAPYSSIKVFCAASESLSTNHSLPLSSHNSCSTARGVSRSATLTMWNFEEDKRKILSMKVEDKRKRYRCGNVFVTLRDLPNWPNYGRENSYVLKQVALNDAAVAKVLEGSIYKVDSDLNKKISLFIGDITTLEIDAVVNAANNSLRGGGGVDGAIHKAAGGMLYQECQSLNGCDTGDAKITGGYYLPARYIIHTVGPTGEKPAMLESCYRRALQTAIENNIRTVAFPCISTGVYGYPNESAVKVVLPIIRTMLEANRDKFDRIIFCLFLSVDINLYHKLLPVFFPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NC69</accession>
    <name>A0A8J5NC69_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Paternally-expressed 3 protein-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Peg3-L1</name>
        <name evidence="2" type="ORF">Hamer_G000611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NC69"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="779"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="809" mass="87436" checksum="529E60C6B62D8F08" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCP0</accession>
    <name>A0A8J5NCP0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000216">
        <property type="protein sequence ID" value="KAG7178281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCP0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7178281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="120" mass="13713" checksum="E21AC1D2AA052B4B" modified="2022-05-25" version="1">MKHIHYNTSSTTHPLQRILYTTSTTTHPLQHTLYTTSSTPHPLHYFLYTTSSTTHPLHHILCYTTSSTTHPLHTSSTPHPIHHIHYTTSTTSSTAHPLQHIPLQHIRLLTHIPLQTSTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCQ3</accession>
    <name>A0A8J5NCQ3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger protein 821-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Znf821-L1</name>
        <name evidence="2" type="ORF">Hamer_G000616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCQ3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="287" mass="34311" checksum="BCF022AAF3833430" modified="2022-05-25" version="1">MKKNIRVMKENIRVMKTSIMPRKRKSSYANTPHAQKMRLRRQYESCDAREERLSRQRQRQTESRQNETLGEHQERQEQDRFRHIVARRNESEEDRQQRLIADTFRHMVARRNESEEERQQRLIADRNRYQNLRQLCLLLMEIQIKLVVALCFQRPILVVLDTFMRKGPEEVCVGYDDEEDRQHPPYKTYKRDQTKWRLGFNQSGIRQQKTAAAAFHHNEDPEPLQKLQPPPHDDSEQRHHKFRLAAASTHSCHWHANIFIQPGYVGNQADLGTKPSVQKWADSPQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ND46</accession>
    <name>A0A8J5ND46_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G008266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ND46"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="68" mass="7756" checksum="A7CD7D796C8D4739" modified="2022-05-25" version="1" fragment="single">SPPPRRVLNSVPCLRHLVHQSPVLLFSKHLAHLASSSECDRFQLQKEILNIRTRDKVSFAEARNAVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NEA6</accession>
    <name>A0A8J5NEA6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NACHT, LRR and PYD domains-containing protein 10-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Nlrp10-L2</name>
        <name evidence="2" type="ORF">Hamer_G008363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NEA6"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="287"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1063" mass="122022" checksum="47E0345A91ECFAB7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NFM9</accession>
    <name>A0A8J5NFM9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Urocanate hydratase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Uroc1-L</name>
        <name evidence="3" type="ORF">Hamer_G008365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NFM9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006548">
        <property type="term" value="P:L-histidine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1770.10:FF:000003">
        <property type="entry name" value="Urocanate hydratase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="entry name" value="Urocanase like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1770.10">
        <property type="entry name" value="Urocanase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="UROCANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216:SF3">
        <property type="entry name" value="UROCANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase Rossmann-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase C-terminal" evidence="2">
        <location>
            <begin position="189"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="425" mass="46774" checksum="F9CD9694EC9183E2" modified="2022-05-25" version="1">MSGAQAKAAVVCGCIGVVAEVSKEALLKRHKQGWLEEYTDDLEVLVRRIREARTKKQATSIGYQGNVVNVWERLLREYETTGELLVDLGSDQTSCHNPFSGGYCPVQLTFDQAEEMLIKNPNKLKTLVQESLRRQVVAINKLSDAGLFFWDYGNAFLLEARRAGADVGAVGADSIKFRYPSYVQDIMGDIFSLGFGPFRWVCASGDPTDLQKTDEIACEVLQAICEEGIPERIRQQYTDNMKWIRQAGEHKLVVGSQARILYSDQVGRVRIAQAFNDAVRTGKLKGPVVVSRDHHDVSGTDSPFRETSNVDDGSAFTADMAVQNFVGDSIRGATWVSLHNGGGVGWGEAINGGFGLLLDGSEDANYRASLILNWDVSNGVARRAWSGNENAESTILRSMTLDRRLKVTFPHHADPSLVARALDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T156</accession>
    <name>A0A8J5T156_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin-related protein 2/3 complex subunit 1A-like 24</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit 1A-like 7</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 1A-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Arpc1a-L24</name>
        <name evidence="7" type="synonym">Arpc1a-L7</name>
        <name evidence="6" type="synonym">Arpc1a-L8</name>
        <name evidence="7" type="ORF">Hamer_G027765</name>
        <name evidence="6" type="ORF">Hamer_G028183</name>
        <name evidence="8" type="ORF">Hamer_G030270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026805">
        <property type="protein sequence ID" value="KAG7162880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010012651">
        <property type="protein sequence ID" value="KAG7171225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010011748">
        <property type="protein sequence ID" value="KAG7171734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T156"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7162880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7171225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7171734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="95" mass="10461" checksum="7E7F51AF2602633C" modified="2022-05-25" version="1">MALFTSRGPVAEVFRFGLVPIACRARNEDRSQVALSLNNNEVNIYGRAASEWKLQETLQGHDLRVTGIDWAPSTNRIVTCGAVSLLCIYLTFSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T3C6</accession>
    <name>A0A8J5T3C6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Ada2-L2</name>
        <name evidence="14" type="ORF">Hamer_G022506</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010011388">
        <property type="protein sequence ID" value="KAG7172395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T3C6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013659">
        <property type="entry name" value="A_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006331">
        <property type="entry name" value="ADGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01431">
        <property type="entry name" value="adm_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08451">
        <property type="entry name" value="A_deaminase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035145113" description="Adenosine deaminase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine/AMP deaminase N-terminal" evidence="13">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine deaminase" evidence="12">
        <location>
            <begin position="206"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7172395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="575" mass="65195" checksum="982FF31062A7B43B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T8Q1</accession>
    <name>A0A8J5T8Q1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc finger protein 862-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Znf862-L12</name>
        <name evidence="1" type="ORF">Hamer_G023456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009918">
        <property type="protein sequence ID" value="KAG7173431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T8Q1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF9">
        <property type="entry name" value="ZINC FINGER PROTEIN 862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7173431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="402" mass="45715" checksum="0E6F01B327AA3C73" modified="2022-05-25" version="1">MTGCRNGLVARLRRYLEKLELEGIHYTAHKIELTYKDAVKDVPLAKKVDLLLLGIYLFYEKSSLNRSMLKHAHDICQQIQNPDDPAYHKDSFRKAKNYLLLLISADIAQYLHLLLDVVRCLGDLSELFQHGQTNISAIVNELQTAVDVLNKYLTWPGPSPRRIMESDTTMFQGEKLSGRSNTFKNVRYDMLTSLISSLNKRFIDMASTSLQNTWILNFKLWPAEYSGNKNFGDSAVQALAQALEKTLMEAEVNPTLAEDEWTVLKSYNYKSKTSLVSRLSWQQINQSYGERCASFLHLVDLQLSIPASSADIECGFSQVKLIKTDWRSRLTDDHLTDLMVVQLQTVCVGNFNPDKAIPRFLTTGARHVDGYTHTAGCSTVEDLDDNNELNEEHVQEMLVQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TAS6</accession>
    <name>A0A8J5TAS6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Basic helix-loop-helix transcription factor amos-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">amos-L3</name>
        <name evidence="10" type="ORF">Hamer_G017990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009070">
        <property type="protein sequence ID" value="KAG7173701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TAS6"/>
    <dbReference type="OrthoDB" id="6161578at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016360">
        <property type="term" value="P:sensory organ precursor cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19715">
        <property type="entry name" value="bHLH_TS_amos_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000025">
        <property type="entry name" value="protein atonal homolog 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF162">
        <property type="entry name" value="TRANSCRIPTION FACTOR ATOH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="199"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7173701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="267" mass="29249" checksum="8EAFEE1F7C8788D1" modified="2022-05-25" version="1">MSVHTGEYWSGRDPSQQYYPLGEFNYNTENYPGATLSPGLEGTPATAMPTQLGPPHQPHDLLQSCVDGGGSDGYHSSTPDDLTSECSPRSELPGPGSSGGSRNKDLMSEAYPNLEYYQAAYPTTTDLSSLTPAYSYASSSTTSVSSWGTTQYSPSEGDANPHQEHFIPPETSPSLVTHYKPLRIRRRPPKVVGNEVIRKRRLAANARERRRMNGLNDAFEKLREVVPELGNDRKLSKFETLQMAQTYITALAELIRRADSESGASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TI23</accession>
    <name>A0A8J5TI23_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G015319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7175096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TI23"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="9408" checksum="104D4595F75232CA" modified="2022-05-25" version="1" fragment="single">MEDVHSLVEWIRRVTQTRSRTAVNSTSVVSGASLTMCTTRPPRADTPASDLCALQLPRSNIPVCPYVNYNLQKQVCLVDEYAGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLP7</accession>
    <name>A0A8J5TLP7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent RNA helicase DDX28-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Ddx28-L</name>
        <name evidence="1" type="ORF">Hamer_G024803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006907">
        <property type="protein sequence ID" value="KAG7174797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLP7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="74" mass="8202" checksum="5D22D1C45CA92AC4" modified="2022-05-25" version="1">MPAVVREGRFNTFQSGEVLALSCTDLTSRGLDTVKYAARKVEEFPNVNANITRIIAAHALKENERLINKANNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J9H3</accession>
    <name>A0A8J5J9H3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043433">
        <property type="protein sequence ID" value="KAG7154917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1602"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1633"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1661"/>
            <end position="1680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1682" mass="204346" checksum="B23D6C37BAF9D110" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JBG0</accession>
    <name>A0A8J5JBG0_HOMAM</name>
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        <submittedName>
            <fullName evidence="8">Organic cation transporter protein-like 18</fullName>
        </submittedName>
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        <name evidence="8" type="primary">Orct-L18</name>
        <name evidence="8" type="ORF">Hamer_G023382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045429">
        <property type="protein sequence ID" value="KAG7154083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JBG0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="81"/>
            <end position="101"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="406"/>
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    </feature>
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            <end position="534"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="567"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="593"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
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            <begin position="254"/>
            <end position="688"/>
        </location>
    </feature>
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            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7154083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="734" mass="81698" checksum="A8851E1FF68DF936" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDB3</accession>
    <name>A0A8J5JDB3_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019241</name>
        <name evidence="3" type="ORF">Hamer_G029553</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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            <taxon>Malacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155835.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7165573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="171" mass="19323" checksum="62B90238977E3272" modified="2022-05-25" version="1">MSYPYPHHVPEENLINLRSSEISELYHQSILPLCNQVQRLTNQMEQGVSSPTRSVKMETGVSQSEQRGEPMHKEDHVDIFPQVVAHEMKLRTFSGTPDNLNQINVGEWIAEAKRNIRLLGYKGRGSVNYILKFLTGPAQKRVEKLAWSDSCDSEGVLAVLKDTYGENLTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEP8</accession>
    <name>A0A8J5JEP8_HOMAM</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="3" type="primary">Ccdc13-L</name>
        <name evidence="3" type="ORF">Hamer_G010609</name>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148">
        <property type="entry name" value="NF-KAPPA-B-REPRESSING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7153313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEQ3</accession>
    <name>A0A8J5JEQ3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitogen-activated protein kinase kinase kinase dlk-1</fullName>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Death-associated protein kinase-like kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MAP3K12-L</name>
        <name evidence="17" type="ORF">Hamer_G015843</name>
    </gene>
    <organism evidence="17 18">
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        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Multicrustacea</taxon>
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            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
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            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010038275">
        <property type="protein sequence ID" value="KAG7156917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEQ3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000087">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF304">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 13-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="104"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="463"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="582"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="757"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="875"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="928"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="965"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="504"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="631"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="842"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="886"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="972"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="110"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038165-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038165-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7156917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="989" mass="110968" checksum="7CBFB7211638F35B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JES1</accession>
    <name>A0A8J5JES1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U-scoloptoxin(01)-Cw1a-like 38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G024109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038351">
        <property type="protein sequence ID" value="KAG7156867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JES1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="108"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="336"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="452" mass="49088" checksum="CC9B4A49A5F551A0" modified="2022-05-25" version="1" fragment="single">QGKVQRGTIKRCQHLQQHSANHSLSTNTMMTKCMALLTLSLLGVTYGQVGYNQPPPPPAYSYGAPELRSAASSLVEEEDPIAALAALIPGGGVPGEDYPILASVPDTGFSCEQQEFPGYFADTADEAGCQVFHICQFDGRQDSFLCPNGTIFNQQYFVCDWWFNVDCAASQQFFGLNAEIGKIPEDAVASFRSDVVAPSQQYGAPQQRQSAPAPPPTPSQFYNSPNRFQGKVQRGTIKRCQHLQQHSANHSLSTNTMMTKCMALLTLSLLGVTYGQVGYNQPPPPPAYSYGAPELRSAASSLVEEEDPIAALAALIPGGGVPGEDYPILASVPDTGFSCEQQEFPGYFADTADEAGCQVFHICQFDGRQDSFLCPNGTIFNQQYFVCDWWFNVDCAASQQFFGLNAEIGKIPEDAAASSRSNVVAPSQQYGAPQQRQDTPPPSQFYNSPNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEV0</accession>
    <name>A0A8J5JEV0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Titin-like 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Ttn-L11</name>
        <name evidence="13" type="ORF">Hamer_G024194</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042260">
        <property type="protein sequence ID" value="KAG7155276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <sequence length="4009" mass="448505" checksum="902C67831888C69D" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEX9</accession>
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            <fullName evidence="2">DNA repair protein XRCC3-like</fullName>
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        <name evidence="2" type="primary">XRCC3-L</name>
        <name evidence="2" type="ORF">Hamer_G010684</name>
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        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
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            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">GMGI-L3</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="319" mass="35027" checksum="43DE487F16286F39" modified="2022-05-25" version="1" fragment="single">DILQGQQTPPPGTPPLCPPPCALPHRESQQPVKVLIVAGSGEKFYKETIILRILVTLGKGGPSQETARELRSSWCSRGSSGSEFGPSIKLTTAVMTSATVEDLFINPRIITRAKITWEMQNTDQERFLHITTGCHQLDDFLGGGIPVRGLTEVTGESGSGKTQLVLQLALYAQLPPISGGLGKGVAYICTESQFSSNRLQQLISHIRNKYPKGPKSYTDNIFVHHVPDMVTAAMGKQSLYGLEGNTAPALGLSWANLVTTRLMLTRTHSFVRTHKLLPQTTVEFNIRKLEVVFCPWLRRKSFSFIVTEKGIEDIAMSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JF71</accession>
    <name>A0A8J5JF71_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Tigger transposable element-derived protein 1-like 330</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TIGD1-L330</name>
        <name evidence="2" type="ORF">Hamer_G006494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JF71"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="162" mass="18260" checksum="F46DBABA907652C5" modified="2022-05-25" version="1">MRLNKQAQQGGFVEVESADVEELLESHCEDLSTEDLQQLVAAGEIEDAEDDEVKDAKPRELPTSVLSSILREVDKQLQILEGNDYNAERSRIAVRGVKSFLAPYEQLLCERRKMAKQQTLGVFFKLTPKKQSKPQSEDSEPQPSTSGIRRFFSSLPCNQNCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JFF7</accession>
    <name>A0A8J5JFF7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein cereblon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein ohgata</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CRBN-L</name>
        <name evidence="16" type="ORF">Hamer_G016046</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Has an essential role in mediating growth by negatively regulating insulin signaling. It also has a role in maintaining presynaptic function in the neuromuscular junction synapses of third-instar larvae.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Likely a component of a DCX (DDB1-CUL4-X-box) protein ligase complex. May interact with pic/DDB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CRBN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041065">
        <property type="protein sequence ID" value="KAG7155669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JFF7"/>
    <dbReference type="OrthoDB" id="267517at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd15777">
        <property type="entry name" value="CRBN_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.20:FF:000005">
        <property type="entry name" value="Blast:Protein cereblon homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034750">
        <property type="entry name" value="CULT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46732">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE LA (LON) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46732:SF8">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE LA (LON) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51788">
        <property type="entry name" value="CULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="14">
        <location>
            <begin position="127"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="CULT" evidence="15">
        <location>
            <begin position="373"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7155669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="493" mass="55951" checksum="B9F82611E214396D" modified="2022-05-25" version="1">MADREERRVGQDVEEEMEDELNDDMAVEMDEGDGGQQGGEDVAQGDVVEEQPQELVLMEEVLVDEDANSWAEYESCEESDGPDGNGSGDDGFGEQYDTTLPSRHVYLGETEELRGRTVQEENDYVTIPLLMHSSLMNLVLVPSQTLPLTIFHPLHMSMLRNVISKDRTFGIVHSKISQDGNSEMAKYGTTAEIYEYQEEDFTDSLSIKAKGRQRFKVISTHRETTGLIVAKVQILPEIRMENPFEMMRLQSLDKLTLPRPQEAYCHVAQARDLASVRTPNSWRVRGWNAWLTPWPSWVYNQYDDLLLAQRVVNEIKKSTMIQPNMLKLPRDPQDLSHWAAINLPLDDSHRLALLGLNTPTQRLRYILSVISKCKMLTCIQCTEVIGDTADIFSMSVEGPQGTFVNPGGYVHEMLTLSKASNLTYYGRPSIEHSWFPGYAWAIANCSSCHSHLGWKFTATKRKLKPQKFYGVTRKAVKAKLVWDGDDGKMRHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHC1</accession>
    <name>A0A8J5JHC1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041065">
        <property type="protein sequence ID" value="KAG7155590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHC1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="172" mass="19271" checksum="012D6B51A5FDE369" modified="2022-05-25" version="1" fragment="single">MISGCSNEMLNQVMIWTCPGNGLDPHYWSNVAVSCGTESTKVKEEEGEVVTERGRRREESRRRRGRRREDGAHPSSAYEEAVIPPPTYQEALLKMVSAITGTLSVISKLLKVKLASYKMVPPRRPSENSPTKAWMCREDDPNLLCMAHTRTPASIYKETYNTLSLSVNVTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHU5</accession>
    <name>A0A8J5JHU5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Disulfide-isomerase-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Pdi-L2</name>
        <name evidence="3" type="ORF">Hamer_G018249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044460">
        <property type="protein sequence ID" value="KAG7154498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19991">
        <property type="entry name" value="L 2 01289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19991:SF3">
        <property type="entry name" value="LETHAL (2) 01289, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1514"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="753"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="918"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1546" mass="177675" checksum="BDDDD26B51413234" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIC9</accession>
    <name>A0A8J5JIC9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-CoA acetyltransferase, cytosolic-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Acat2-L</name>
        <name evidence="8" type="ORF">Hamer_G006305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIC9"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="7">
        <location>
            <begin position="273"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7158927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="396" mass="41217" checksum="EC7F986FF688ADA2" modified="2022-05-25" version="1">MAANRVVIASAVRTPVGSFNGGLSSLRSHELGSLVIKEALSRASVVPEDVSEVLLGQVLTAGEGQNPARQAAVSAGLPYTVPASVINMLCGSGLRSVSMGYQAIKLGDASIVVCGGQESMSQAPHAIHLRSPVKMGDATMVDIMMKDGLIDAFHNYHMGVTAENVAKSWNLTREQQDIFALKSQEKAEAAQQAGHFEQEIVQVVIPGRKAATEVKVDEYPRPGSTLAGLTKLKPCFITDGTGTVTPGNSSGINDGAAALVLMSESEAKHREIKPLASVVSWAQAGVDPAVMGTGPIPAVKAALKKAAWGIDEVDLWELNEAFAAQSLAVIQELGICMEKVNVNGGAIALGHPIGASGARILVTLLHAMLRLNKKRGVASLCVGGGMGIAVCVERFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIY5</accession>
    <name>A0A8J5JIY5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SCAN domain-containing protein 3-like 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ZBED9-L18</name>
        <name evidence="1" type="ORF">Hamer_G023865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042696">
        <property type="protein sequence ID" value="KAG7155188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIY5"/>
    <dbReference type="OrthoDB" id="10062525at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF19">
        <property type="entry name" value="LOW QUALITY PROTEIN: ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="176" mass="20314" checksum="24F6740725ABBECA" modified="2022-05-25" version="1">MSLGKCLQPKDEVIDDKMTTVVSQHLTVPQHYFNHYFPPANEEEKKKNSWIRNPFLISNLNDSDLPTQEKDTLIELYCDSEMKDFCNSRNRTDFWVAVSQKEAYEMNAGKALQFLVAFHSTYSSERGFSDLLTNKRKKRQRLGETMLSACMTVAATRNIAPRFNLLAATIQQQKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJZ5</accession>
    <name>A0A8J5JJZ5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G004234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJZ5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="122" mass="13872" checksum="BFCB360855419B84" modified="2022-05-25" version="1">MPGTNLTREEKVRILTLIEEKVPVNEIVRRTGRNKATIHRLKAVARDLPPASVPPAKPRSGRLRKTSKTTDALLRREVLKTPHITAAELQRNHPDVLGNVAQRTIQHRLKKELHLPCRRPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKU1</accession>
    <name>A0A8J5JKU1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cc8K15.2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="75285" checksum="6FE1774AE9372719" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLW2</accession>
    <name>A0A8J5JLW2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U-scoloptoxin(01)-Cw1a-like 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030986">
        <property type="protein sequence ID" value="KAG7160697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="269"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="629" mass="61460" checksum="E0B26823E9443CAB" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JM75</accession>
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    <protein>
        <submittedName>
            <fullName evidence="3">Polysialic acid O-acetyltransferase-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">neuO-L4</name>
        <name evidence="3" type="ORF">Hamer_G028138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035686">
        <property type="protein sequence ID" value="KAG7158099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JM75"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="entry name" value="Serralysin-like metalloprotease, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="Adhesin YadA, collagen-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="484"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
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        <location>
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            <end position="549"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="159"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="656" mass="73173" checksum="C03B9CBFA60D4713" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMU9</accession>
    <name>A0A8J5JMU9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">U-scoloptoxin(01)-Cw1a-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G005801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037514">
        <property type="protein sequence ID" value="KAG7157378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMU9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF31">
        <property type="entry name" value="FI18007P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035264388" evidence="3">
        <location>
            <begin position="20"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="4">
        <location>
            <begin position="112"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7157378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="241" mass="26801" checksum="4E511C3358C40FDF" modified="2022-05-25" version="1">MTMMKQLLVLVALAVSTSARMAGMLPGGSGALQSGFSCIDRPFGYYADVENHCKAFHVCYPVTEEDGTLTETAHFSFICAMMKVVLLLVTVLAAASARMSGRLPGGFHIDPGFSCESRAYGFYADIQNSCSAYHICHPVYDETEQLVEMAHFTFLCGPGTIFDQELLACAHPKKAFPCSESDTIYEHSNLQLLIDWREKNRAQAERRAHTLERAQEEERAQAELRSQANERPQATESEELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JN73</accession>
    <name>A0A8J5JN73_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 4C-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Arl4c-L3</name>
        <name evidence="6" type="ORF">Hamer_G025616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039790">
        <property type="protein sequence ID" value="KAG7156159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JN73"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7156159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="205" mass="22642" checksum="CA5CB34992796C57" modified="2022-05-25" version="1">MCSCLWVGMAEAAQYLMWEAATLVRPPTHVVLVGLDSSGKTTVLFRLRYGQYVNAVPTVGFNTEKVRAGGGHWLVWDVGGAERVRPLWRSYTRATDALIFVVDSSSCEERLEENRVELQRLTKQQTAQCVALNRARPPLLVLANKQDLPGAREPQHLAKAMGLPELPDTQPWAVAPACAVTGEGLDEAMALLYQLVTKTRQASKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JN79</accession>
    <name>A0A8J5JN79_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Helitron helicase-like domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G029795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033752">
        <property type="protein sequence ID" value="KAG7159266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JN79"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="357"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="455" mass="53453" checksum="C921C29CE2E29CFB" modified="2022-05-25" version="1">MRLRRQSESCDAREERLSRQRQRQTESRQNETLGEHQERQEQDRFRHIVARRNESEEERQQRLIADRNRYQNLRQHEIQNAKHSALLYDKNDPCNKAAIGEMTKLCQCGAKKFTGESLGMCCGNGKVTLDQFPPLPQLFEELFTGESQFSKHFLSRLREYNSLFAMTSFGHKDASVQGWNPSVRIQGQIYHQLGSLMPPEDRRARYIQVYFLDTLEDQLRARGEHQNLNADILERITAWLNENNHYVGELKTALEQVRQVNINDKKIVIWENKRAQGEHARRFNAPTGAEVAILMSNEPTENRDIVLQLKQGGLRRISELHRSYDPLMYPLFFPYGTDGYHIYLQGRNGRKVTQLQFYSFHIMCREGNYLLLGRRLFRQFLVDAYCKIETERLKFLRREQQSLRAENYSDLRDSLLAADGDPNQVGRRIVLPATYTGGPRYLHEKRSDAMAFVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNG9</accession>
    <name>A0A8J5JNG9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamate receptor 2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Gria2-L2</name>
        <name evidence="11" type="ORF">Hamer_G004130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNG9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="54"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7159498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="335" mass="37771" checksum="EF92E0768383B2D2" modified="2022-05-25" version="1" fragment="single">EADLGLGPFGVSATRAEMVDFTRSILIDNLRIMGGLGHPEVDPWGFLLPLAPLVWVSILVTLAVVLVAVFLLSLCFLPQRHNRLEWFLDIFFSFIRVLFQQDAWVTGGWWWERLVLGAWMLMVLVLIRSYAGTLMSILAVRYIPQPFQSLRELLDDRSTTMIWEVGTVYMQYLQAVKTGIFSEVMASENDGRLKLVLTTEYLHMADTLVTEGRHALVIEDLTGKVIMADHFSLIGECNFYQSREVFLPVFLSMIGQKNHPLVPALNNRIKSVTEAGLYGYWMKHLSINSTRCIRPPTKITVNNSLSVANLWGMFVMLAGGHVLALVVLGIELLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JP38</accession>
    <name>A0A8J5JP38_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminopeptidase O-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Aopep-L</name>
        <name evidence="2" type="ORF">Hamer_G013988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JP38"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033577">
        <property type="entry name" value="AOPep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46627">
        <property type="entry name" value="AMINOPEPTIDASE O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46627:SF1">
        <property type="entry name" value="AMINOPEPTIDASE O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="1">
        <location>
            <begin position="802"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="953" mass="108961" checksum="018876B1061C26A5" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JP41</accession>
    <name>A0A8J5JP41_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G001019</name>
        <name evidence="2" type="ORF">Hamer_G029883</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035571">
        <property type="protein sequence ID" value="KAG7158128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JP41"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF1">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="454" mass="50877" checksum="8DC7A7C6AE713BF5" modified="2022-05-25" version="1" fragment="single">EERKGGSEAFDEPIIRQLAEFESSQKAEQTKANFHHHEQTNTTQDKSRAVKSVQNVVKLGREQFHSYLADKITDAPHVTSIILDEPAVVEMLKPGGSSTFQEYSTAVFIPYIESQLEYRSRLDLVWDCYLKSGSLKATVRCNRGKGIRRRVTASGPLPSNWQNFLCNSDNKEELFSFQSEQVVQLVIKESKQLVVTDKKQVLTVPPRKDTANLAPCNHEEADTRMMVHAADALECGHRRVLIRHVDTDVVILAITLANERSEVLDELWLTFGIGKNRRYKAAHQTAKALGPEKSRALPVFHAIAGCDTVSAWATWNAFPEVTTAFLSLASTPSELPDGVLSTLERFIVLLSDRTSTCCDVNMLRKKLFSRKSRSLEDLPPTRAALEQHIKRAAYQAEHIWGQASIAFVSLPSSCDWGWMKSGDELEPHWTTLSEVSKSCHELISCGCRKHCGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPG0</accession>
    <name>A0A8J5JPG0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035458">
        <property type="protein sequence ID" value="KAG7158338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPG0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="425" mass="47403" checksum="99773F091AC7B21C" modified="2022-05-25" version="1" fragment="single">STSMVEQTTREMTSSPVVSLIGEIEALRFTPHSQSFPHSYTSHESFPHSYTSQRVLPSLLHLTVSSSLTHTPLSPSLTPTHSESFHTPTHHSESFLHSYTSQRVLPSLLHITASPSLTPISHESFPHPYTSQRVSHLLHLLSESFHTPHITVSPSSPLRSQWGVPSHTPTSQRVLLTHTHHMSPSPTPTYHSESFPHAYTSQQDLPSLLHITMSPSHTPTHHILPSLLHNTASPSLTPTQHCRSFSHSYTTPQVLPSLIHNSTSPSLTPTPHYKSFPHSYTTLQVLPSLIYQATNPSLTHTPHYKSFPHSYTILQVLPSLLHHTTSPSLTPTPHYKSFNHSYTALQVLLSLLHNPLSPSVTPTPHYKSFSHTYTTSPFLSPTPHYKSFSHSYTALQVLLSLLHNPVSPSLIPTPHYKSFSYSFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRM9</accession>
    <name>A0A8J5JRM9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lactoylglutathione lyase</fullName>
            <ecNumber evidence="3">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aldoketomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ketone-aldehyde mutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Methylglyoxalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">S-D-lactoylglutathione methylglyoxal lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Glo1-L</name>
        <name evidence="14" type="ORF">Hamer_G023510</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyoxalase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010029887">
        <property type="protein sequence ID" value="KAG7161126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRM9"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="28"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7161126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="186" mass="20975" checksum="FDD47CC0CA5034C8" modified="2022-05-25" version="1">MAQEPAGLTKEEALACCAEPDEATKDFIFQQTMFRIKDPKASLDFYTRVLGMRLLQKLNFPSMKFSLYFMGFESAKDIPQEEDERTTWCLSQKATLELTHNWGTESDPNFSGYHNGNSEPKGFGHIGIMVPDVEKACARFESLGTKFIKKPTDGTMKNIAFIQDPDGYWIEILNPSCVVQAVKQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRY5</accession>
    <name>A0A8J5JRY5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G032143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035713">
        <property type="protein sequence ID" value="KAG7158094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRY5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="522" mass="58632" checksum="252930A6181210CD" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSV7</accession>
    <name>A0A8J5JSV7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endochitinase-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Chit-L1</name>
        <name evidence="3" type="ORF">Hamer_G001649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSV7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF144">
        <property type="entry name" value="CHITINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="16"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7160409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="299" mass="33112" checksum="AD4780FCB4268054" modified="2022-05-25" version="1" fragment="single">YGTDVVVGRGSDERDGRRVSSATSPTGPYTDLDSAATASATSLSKSVHIVYSFVGVSNVTWEILVLDPELDLDKNGFQLHEPAKANPNVNSMLAIGGWEKWKYSQMVQIPREGPRSSPASIHEPLQFDGFDLDTGVSRGHRRGGTYSDKKPLDFVKELRAAFDKEGKGWEISMAVPVAKFRLSEGYHVQELCYYVDAVHAMTYDLRGNWAGFADIHSPLYPRPFDQFAYETLNVNDGLKLWVDRGCPKDKLIVGVPFYGRTFTLGSKKSNGLRAPVKKWEGGGKPGPYTDAKGFLAYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVJ7</accession>
    <name>A0A8J5JVJ7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7160029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVJ7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="417" mass="46184" checksum="8659F4002E36F182" modified="2022-05-25" version="1">MLAIKKYFTSRRGRSSDEFETPRGLVCTCPHGTGSSVNVGGAGVSEKPRRRTREKDDLSLPSPSLLRRHQTSSSPSVRQYPTSSSPSVRQHSATSSVRQAIDDEGPSCSSASRYHRYRRSVSLDQILQSSDGSHSDGGLTTTTHYPYSSASLDPPDHHPPGGDADGGRELSDFEKENLLFLRDLDNSYYRPLTHSLSNTSLGSTFSEDSLAGESTPRGGSPYPGRREYPRTAYSPSKTSPSKIIRSISREEDEDDLSEDEIGRGKDRDSFKRKISLPVFMGRGSTSDSSAPSSVCSLPGSSAWWSHKPVRLPPPRKYSTNHSPPYTSSINQAKMLFTNRSFSSPAGQSTSSTTPANKKVNEISFITWDDSPPPVSRPGKDQWEEEVEEEVKEKKEEVKKEDEESIRTRKKKKKEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVS5</accession>
    <name>A0A8J5JVS5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVS5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="33" mass="3487" checksum="8DCFAFB1B9472670" modified="2022-05-25" version="1">MGRLGHQLEGCGEEPSASARIKRSIYIIGAQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVY1</accession>
    <name>A0A8J5JVY1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PX domain-containing protein kinase-like protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Pxk-L</name>
        <name evidence="6" type="ORF">Hamer_G022328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028009">
        <property type="protein sequence ID" value="KAG7162239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVY1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043271">
        <property type="term" value="P:negative regulation of monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006622">
        <property type="term" value="P:protein targeting to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22062">
        <property type="entry name" value="WH2_DdVASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF40">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="135"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="498"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7162239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="563" mass="62641" checksum="2783B3DE00A36B96" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW27</accession>
    <name>A0A8J5JW27_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glutamate receptor-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Glrk-L3</name>
        <name evidence="15" type="ORF">Hamer_G001563</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW27"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="13">
        <location>
            <begin position="8"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7160344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="477" mass="53579" checksum="3BEB7E3105636A8F" modified="2022-05-25" version="1">MLFKQSVSLVVSGVEWKPHLDFVKAPDGHLTVQGPVANLLNMVAASLNFTYSLVTPEDQAWGRKLPDGNWTGMVGQVFRQEADIALGPFAQSEERRQAVDYTQSFFFDGRTIIAGKGRPEIDPWSFMLPLQPPVWVALLVGLVVAWLSLVVMGHNPKDSSQLTSASHFMRTSHLLFQHLRIILRQDVSMNMTRGREMVLMGGGVGGGDVGTLVSLLAVRHVPQPLQTIRDVLDATHITVVLEGANTIVPVTLAKIKTGELKELNDLKYFGRIKYKTPALFKKEVEPLVRRGDHVQIENTLTINSHIDSGFATTRRCDFYKGRQTFFITQHCLIGQKGNPIVAALSRRIRSVVEAGLYPYWLDKSLPAYHNCRHSPSKITVREPLALDSFWISRKKVLKSQHDGRCLQHKFCLGKCDQQRVNVGEVKGVRLIPEVVNMVKITESRTRTKMCKSKPTFTEYFHGVLEILGRQHCIIILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW61</accession>
    <name>A0A8J5JW61_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glutamate receptor ionotropic, kainate 2-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Grik2-L8</name>
        <name evidence="15" type="ORF">Hamer_G007896</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW61"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="133"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7162374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="372" mass="41554" checksum="4846E2A7E0942D20" modified="2022-05-25" version="1" fragment="single">LRQVSWSVTVVVVSDDPAFLAALAKWTLKGRLLVWSTRLLAVTRLPLPELQHLHKTFSMTNAMLLILENNSLSLYVHLPFTPKEAQALKIASWSPQRGLVLTTHLQIFPEKFSTFYNGPSLLVAAEEFEPHIALVEETDGSSAVPSFTGPMVNLLEILADTMNFTYRYIRPPDGSWGVKREDGSWTGMVGMVGRGEADIGLGPFGVSATRAEMVDFTREIITETARIMGGRGLPEVDAWGFLLPLAPLVWMGILAALLVMPAVVLLMSAFSGFKTSSNNLWSSDRFFGYIRVLLQQANTASPDLWWERTVLATWLITILILTKSYAGNLMSNLAVRYIPQPYQYLRDVVDDSSVNMIWETNTAYVQYFRVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JX78</accession>
    <name>A0A8J5JX78_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptor Mth2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mth2-L2</name>
        <name evidence="8" type="ORF">Hamer_G002211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="8">Heart &amp; testis</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JX78"/>
    <dbReference type="OrthoDB" id="6134459at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052808">
        <property type="entry name" value="GPCR_Mth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010596">
        <property type="entry name" value="Methuselah_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06652">
        <property type="entry name" value="Methuselah_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="411"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="747"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7163135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="789" mass="89037" checksum="DE20C9A3213B4B7C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXN4</accession>
    <name>A0A8J5JXN4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G011201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXN4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8104" checksum="990FBD2C900C9E1B" modified="2022-05-25" version="1">MSDCMLDNARCNDATLHLAYRGRCGDSQERVPYTLCLFTMTLGVTENNGKVYGNECQLNIAICNDPSLKPGSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYS9</accession>
    <name>A0A8J5JYS9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023007">
        <property type="protein sequence ID" value="KAG7166066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYS9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="99" mass="10923" checksum="33A56A34CA522052" modified="2022-05-25" version="1">MAEDLRMVLESGEHFCPQKGYQGALALLSRRFGGERGYAEERITSLLGGRVMGVRKNSLSRPPKNKSSSRQAVGMAVTTDQRATVKTEDEEYKALPALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYU7</accession>
    <name>A0A8J5JYU7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Zinc knuckle-containing protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G007562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYU7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="151" mass="16670" checksum="BECCA6CFCF6C7ACA" modified="2022-05-25" version="1" fragment="single">MGNEIIMNIISKYGKVEGVRLNKYTKRPAVGLLNGTKTFKVNLKNGIPSSLTVGGHTLTFLYAEQRKTCYKCGHEGHLANDKVDEVNIFNEEDFPATQLIGEIHSSKTDVREGEESVKVCQVPATTWFGVEKEEASAQTITQETSTTCEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYZ8</accession>
    <name>A0A8J5JYZ8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Protein-tyrosine sulfotransferase</fullName>
            <ecNumber evidence="3 13">2.8.2.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Tango13-L</name>
        <name evidence="15" type="ORF">Hamer_G011007</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-tyrosyl-[protein] + 3'-phosphoadenylyl sulfate = O-sulfo-L-tyrosine-[protein] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16801"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:11688"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:65286"/>
            <dbReference type="EC" id="2.8.2.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the protein sulfotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.20" evidence="3 13"/>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYZ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000290">
        <property type="entry name" value="Protein-tyrosine sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788:SF10">
        <property type="entry name" value="PROTEIN-TYROSINE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PROTEIN-TYROSINE SULFOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13469">
        <property type="entry name" value="Sulfotransfer_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7166186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="405" mass="45692" checksum="AEF3588D906536EE" modified="2022-05-25" version="1">MMRTRTGSCKPLLSSSSLPSSWYRTKEEGEVPGGPAGWWWVVSVISLTPHLVRYVVTAKCNVVMWRMMRRYLPHAVVGAFILHVASDSSGALHNYDRSEPMIFIGGMPRSGTTLARAMLDAHPDIRCGEETRVVPRILQMRQQWKRSAKEALRLQEAGVTDEVLDEAISSFILDIVVNHGQPAARLCNKDPFTLKSATYLSKLFPNAKFLFMVRDGRATVHSIISRKVTITGFDLSSYKQCLQRWNSAVQTMNTQCDELGSTKCLPVYYEQLVLHPQEWMRKILDFLGVDWDDSVLHHEEHINKPGGVSLSKVERSSDQVIKPINLDALSKWVGQIPKDVVEDMANIAPMLATLGYDPYSNPPNYGQADALVANNTKRIQKELSKWEDRAEEVRSISKHRKGDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZ11</accession>
    <name>A0A8J5JZ11_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">lysoplasmalogenase</fullName>
            <ecNumber evidence="6">3.3.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TMEM86B-L</name>
        <name evidence="10" type="ORF">Hamer_G025536</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:22544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:73359"/>
            <dbReference type="ChEBI" id="CHEBI:77287"/>
            <dbReference type="EC" id="3.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:16905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:73359"/>
            <dbReference type="ChEBI" id="CHEBI:77288"/>
            <dbReference type="ChEBI" id="CHEBI:143890"/>
            <dbReference type="EC" id="3.3.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM86 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.2" evidence="6"/>
    <dbReference type="EMBL" id="JAHLQT010025492">
        <property type="protein sequence ID" value="KAG7164249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZ11"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047408">
        <property type="term" value="F:alkenylglycerophosphocholine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012506">
        <property type="entry name" value="TMEM86B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885">
        <property type="entry name" value="GH04784P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885:SF6">
        <property type="entry name" value="GH04784P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07947">
        <property type="entry name" value="YhhN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7164249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="325" mass="35677" checksum="656171BA1E3EC185" modified="2022-05-25" version="1">MGLETMTSDPPRYFPLLCGSRCSSHAHTPSATPVDTETLSASSSSSTDTHTYLVVFSPVSILNHRTCTSYLLLLLPHLYVSPVHLTCCCCDQLSNNRTMAVKKGAPTSNGSPVHYFLPYLVSVAASLVWYVPAEVPSLVGMVLKCVPIVCLKVFLVVLERGRREANLGLAWPEDLFLVGLAFFGLAQITYIVAFGFSKVSWVVGTALHGGNLLVMMAILPGLPDAVMKIALTFYSFVLVTMIWRAMDRARLRKDLPAERRLCTAAGAVIFVISDVSIAVLQVGRLMPRVYCEFIVLSTYYTAQFLLVLGAAQTFWARRTPVFKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZK8</accession>
    <name>A0A8J5JZK8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Glutamate receptor-like 78</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Glrk-L78</name>
        <name evidence="2" type="ORF">Hamer_G007855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZK8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="163" mass="18656" checksum="C4860C483CDA084E" modified="2022-05-25" version="1" fragment="single">MKSTDQMPAWSALINTSSRRWLSLSSQLHRGLLFSWALLSLNAQADMQKRCVPKTTELADRTRFVRMWMDGESARTIAEKSGTSVTTVYRWIRRWQQKGNVNTMPRRGQCHIALSQEEAEVIQVLMSPRMKNSMIVSGILRHLSRYNSAPYHLLNNGVASGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZR8</accession>
    <name>A0A8J5JZR8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytosolic Fe-S cluster assembly factor NUBP1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Nubp1-L2</name>
        <name evidence="7" type="ORF">Hamer_G019129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026149">
        <property type="protein sequence ID" value="KAG7163858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZR8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7163858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="177" mass="19041" checksum="BBF703F7EE8422CF" modified="2022-05-25" version="1">MSRPQDAPHNVDGVKERLAAIKYKILVLSGKGGVGKSTLTAMIARAIALHDSHEVGILDIDICGPSQPRVMGAEEEKVHSSGTGWSPIYVEGNLAVMSIGFLLNNADDAVIWRGPKKNGMIKQFLRDVDWGALDYLVVDTPPGTSDEHLSIVQYLSAAPPVAAVIITTPQSQLEKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1C5</accession>
    <name>A0A8J5K1C5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G025714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022555">
        <property type="protein sequence ID" value="KAG7166406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1C5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="354" mass="40760" checksum="0E79B68608A5A7C8" modified="2022-05-25" version="1">MDPEEAQGQDHPRSRRTCLRSFRMSYGPVLFLVACGGWMGVGLSAIVTSEGIYGVSDMYYENAIVHSSMRTEERLLETYYPTSGISVQQMLLMCHRRCIQHSNCHSFIFNASGNYCRLTTYDRCADSLPILYKKDGMKTFDVRPGHLPKPIRTCFTECLQGDCWICGRLHCQGEHCDDCAHNCWNEQLKNKTAYLLLWKTEALTLTSKYHCDRGWQKIWRFKKDESSITKSFMYDLLWVNPLSLRLRVVYDDFTVYSYFANFSYSSKIIGVGNFLGGDAGNYWQAPFENLNLKTTCPLFHSVDYNCTSDGDGLYSNLTWLTGNDTLDSKILTEVDIWVTAVGEEWYDQAYPWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2E7</accession>
    <name>A0A8J5K2E7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2E7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="185" mass="19854" checksum="5235E430E9ECE88F" modified="2022-05-25" version="1">MTVDLILGKDLAGGQMGNVTPPPVLREKPEFTAELQHLEDDMPGVFRLCAVTRSMSMTNDHNETPDVDDSLSLGLFANPIASQDIYSAVNAVTGRVAVIAEQEQDDSLRLLFDQVSDSANDSGPTTRYFSQDGSEPSDPPCDPLCDPVHPGYIGRLSSTSLGSSDLSFLRGDSTLAYVIDAMLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3B7</accession>
    <name>A0A8J5K3B7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015294">
        <property type="protein sequence ID" value="KAG7169832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3B7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="218" mass="24780" checksum="115183CAE11E367B" modified="2022-05-25" version="1" fragment="single">IQQELLGNVGKEITDQELEDLARFQEEEEKDEEDQQSIKEGMSLAAVGQLYNVKDSTARTITLKRKKISCQCSTKGQPVREKAMKRCGMKFVFVDRGPASKGVVVESNTRGAGLQATEQVWNMDLNRFVLEKDASDFHRLKKNRGNLVIQGSYDRLHGKKPHAFKHRDMSLLPVFWMYKGAWTTSHLFSTVSTIVSCQRPNATCTQKRIGVWHPANPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4Z7</accession>
    <name>A0A8J5K4Z7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Testis-expressed protein 264-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Tex264-L</name>
        <name evidence="2" type="ORF">Hamer_G023443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016841">
        <property type="protein sequence ID" value="KAG7169407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4Z7"/>
    <dbReference type="OrthoDB" id="2140079at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15949">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15949:SF3">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="360" mass="39611" checksum="D1D8C9EA29F6326B" modified="2022-05-25" version="1">METEVALLWGFLLLMLLAVATVVGLLVHSGLFIPVDVKTCKPDLGEVYIAYKFARGPYKESGTLFTQVHTLLPDYRTIGVYYDDPKMKQSHKLRYIVGVVLSENGSPVVPEHRNLLEEHGYQFTTFPAIDHAVQASFPYNSTISIIVAIMKVYPALREYVETRSLCAHPFLEVYDSKKTEILFVGPLARQDDFYVPEVQQEEDDDHRDDYEDDDRTENSSRSWDESASFIRGGELNDSECSESVGDDSCSYPPPPCEAPTESSTPPSLPIPSQPDEVVETPAALPPPPPPPADTADPTEATADVADTAESASLGGEESDANTGSSFEEIDEKEAAAIPDMSAPAESRETNLKKDEDEGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K585</accession>
    <name>A0A8J5K585_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin-3-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Ank3-L3</name>
        <name evidence="6" type="ORF">Hamer_G010550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K585"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="320"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="526"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="559"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="682"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="776"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="809"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="5">
        <location>
            <begin position="938"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="910"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="921"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7166873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1189" mass="131533" checksum="42B90AAADB6DAD3D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5J5</accession>
    <name>A0A8J5K5J5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative TPR-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G005280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7166978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5J5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035191931" evidence="1">
        <location>
            <begin position="16"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="484" mass="53366" checksum="35D8AF79755C952F" modified="2022-05-25" version="1">MKFVLILVLLSVATCRHLYRRDLDDDDANYDVYYRMMSSQDTDCSNSQSSFHEEGSPISPESATAHVLPTAYQKVDLDSEVLNLPSSFHEEGSPISPESATAQVLPTAYQKVDLDSEVLNLPSSFHEEGSPISPESATAHVLPTAYQKVDLDSEVLNLPSSFHEEGSPISPESATAHVLPTAYQKVDLDSEVLDLPSVCNRTRSTAHVLPTAYQKVDLDSEVLDLPSSFHEEGSPISPESATAHVLPTAYQKVDLDSEVLDLPSSFHEEGSPISPESATAHVLPTAYQKVDLDSEVLDLPSSFMKRFPISSLQPQFYQQHTSLDQRYLTCHRLSMKRVPYFSRVCNRTRSTNSIPEESATAHVLPTAYQKVDLDSEVLNLPSSFHEEGSPISPESATAHVLPTAYQKVDLDSEVLNLPSSFHEEGSPISPESATAHVLPTAYQKVDLDSEVLDLPLSLRKRVPLFLKSLPTADQKVDLESSFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5L8</accession>
    <name>A0A8J5K5L8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G005333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5L8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="141" mass="15662" checksum="CD7C0C71C791BC52" modified="2022-05-25" version="1">MPAVVGVKEILLVEGAGVENAGLKTVSVLKKDDIVHKRQLHHSFPWEGLWLRKTQAPLNEVNALSQNPEIEPPLRFFLLLFVIVTSPLLLKLLELFIGEVLAVGLEQFPVQFLKTSLLSKVNNGLLHSCHISKSKNFCACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8R5</accession>
    <name>A0A8J5K8R5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 229B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Tmem229B-L</name>
        <name evidence="7" type="ORF">Hamer_G013305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM229 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015640">
        <property type="protein sequence ID" value="KAG7169683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8R5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010540">
        <property type="entry name" value="CmpB_TMEM229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31746">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 229 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31746:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 229B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06541">
        <property type="entry name" value="ABC_trans_CmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7169683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="117" mass="13873" checksum="07D87C659E3F62A9" modified="2022-05-25" version="1">MACCTSVWSLFIYGVGSLVMERFYRRYHATVPLPLRGLCYVAWTYLWEFSTGMLLRQYGACPWDYTDRNYNLLGLITLEYFPAWYFAAVLTEQILMHNLLFVSLYSQDSHNRLYHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8V0</accession>
    <name>A0A8J5K8V0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016127">
        <property type="protein sequence ID" value="KAG7169529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8V0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="153" mass="17316" checksum="8E27AFCD2957D29E" modified="2022-05-25" version="1">MVEQTTRAMTSSPVVCLICETEARHFTPHRESFPHSYTSVSPSLTPKHQRDSFPHCYTSQRVLLSFLHITASPSLTPTHHSEYFPHSYTSQRVLPSLLLITASPSLTPTHHNESFPHSYTSQRVLPSLLHITARPSLTPTPHSEFFPHSYTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K9U8</accession>
    <name>A0A8J5K9U8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Hairy/enhancer-of-split related with YRPW motif protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Hey-L</name>
        <name evidence="13" type="ORF">Hamer_G011556</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the HEY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K9U8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000012">
        <property type="entry name" value="hairy/enhancer-of-split related with YRPW motif protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="71"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="12">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="198"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7168883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="367" mass="38694" checksum="37FCCF63FE29FA9D" modified="2022-05-25" version="1">MLSGRATAFSGVKQEAGLYGSSRPPGHLNHVDANICNMKRTLSESDGDDIYSGDEKDLDDCSSSGGGGGASRKRRRGIIEKRRRDRINNSLSELRRLVPAAFEKQGSAKLEKAEILQMTVDHLKMLHTKGLDALAYDPNKFAMDYHNIGFRECAAEVARYLVTIEGMDIQDPLRLRLMSHLQCYAAQRDLANKQAASSWGWGSSQATTTPTTYPAGSSLSGGFQGHVLPPHGATHPSPGPHHTSSLGGLDQSHGMSAFSAPSSSGSNDLGSGGPGCSLGAGQVPRLPTTGSGAPQIPAVTMSTASTPHTNYHLNLNAHTFPANPSNIPNLNLSGNTAPLNAASYNPGLQPGGAGVKPYRPWGAEIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KAI8</accession>
    <name>A0A8J5KAI8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G028534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018285">
        <property type="protein sequence ID" value="KAG7169138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KAI8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="124" mass="13838" checksum="5E06872EF1846A2B" modified="2022-05-25" version="1">MVIYSGSSSQLTPRPPSPNDITSPRLSHLGADNTFSVPYDFYKLTTPLQTSTINDTRDSLYGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIGYSETKKQIANAKKREQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KCD3</accession>
    <name>A0A8J5KCD3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Aminopeptidase</fullName>
            <ecNumber evidence="22">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">ANPEPn-L3</name>
        <name evidence="27" type="ORF">Hamer_G018545</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20 22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="20 22">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="22"/>
    <dbReference type="EMBL" id="JAHLQT010012106">
        <property type="protein sequence ID" value="KAG7171432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KCD3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016285">
        <property type="term" value="F:alanyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000008">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000012">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000016">
        <property type="entry name" value="Glutamyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF294">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22 27" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 20 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 22" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 22" id="KW-0645">Protease</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12 20 22" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="26">
        <location>
            <begin position="39"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="24">
        <location>
            <begin position="262"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="25">
        <location>
            <begin position="569"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="21">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="27">
        <location>
            <position position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAG7171432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="915" mass="103887" checksum="2BF12177C076CF9F" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KEX1</accession>
    <name>A0A8J5KEX1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G012562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KEX1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7170988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="80" mass="8911" checksum="86728F2365A95947" modified="2022-05-25" version="1">MVAVESFAADGSFKYCQFTFIMGVTNEEQTFHLQNIPLSLVGTHNGKQALFQAFTNLLEEICDEVQTPSSSDIQYSLSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KFI0</accession>
    <name>A0A8J5KFI0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Golgi apparatus protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GLG1-L</name>
        <name evidence="11" type="ORF">Hamer_G012257</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KFI0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001893">
        <property type="entry name" value="Cys-rich_GLG1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017873">
        <property type="entry name" value="Cys-rich_GLG1_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039728">
        <property type="entry name" value="GLG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884:SF1">
        <property type="entry name" value="GOLGI APPARATUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884">
        <property type="entry name" value="SELECTIN LIGAND RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00839">
        <property type="entry name" value="Cys_rich_FGFR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51289">
        <property type="entry name" value="GLG1_C_RICH"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035241020" evidence="10">
        <location>
            <begin position="21"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1065"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="196"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="324"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="388"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="525"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="648"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="715"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="899"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="962"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7170035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1097" mass="125654" checksum="CB87D27CB2F70210" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KHB4</accession>
    <name>A0A8J5KHB4_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Putative Tigger transposable element-derived protein 1-like 339</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="primary">TIGD1-L339</name>
        <name evidence="2" type="ORF">Hamer_G011763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
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            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KHB4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="134" mass="15419" checksum="32085C1F0854D938" modified="2022-05-25" version="1">MRVTVRCLCAAWRPLWPECVPQRDFEGFEELEEEAVVHEIVSLGNSMGLEVDDDDVEELAEEHSKELSTEELLELHKEENETLKRSITSEESGEEEESCIIPAKDLKDAFFCWSKLSKLAEDYHPDVVCLMTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJC0</accession>
    <name>A0A8J5MJC0_HOMAM</name>
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        <submittedName>
            <fullName evidence="2">Tigger transposable element-derived protein 1-like 184</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TIGD1-L184</name>
        <name evidence="2" type="ORF">Hamer_G031866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A8J5MJC0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="155" mass="18147" checksum="31656FB3C777C14A" modified="2022-05-25" version="1" fragment="single">WKEVTVRCLCAAWRPLWPECVLQRDFEGFEELEEEAVVHEIVALGNSMGLEVDDDDVEELVEEHSKELSTEELLELHKEENETLKRSLTSEESGEEEDKEESRIIPAKDLKDVFFWWNKLSKLAEDYHPDVGSVQKAISVFNDNVMNYFWKVQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK16</accession>
    <name>A0A8J5MK16_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tumor protein p63-regulated 1-like protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TPRG1L-L</name>
        <name evidence="4" type="ORF">Hamer_G017561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPRG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044465">
        <property type="protein sequence ID" value="KAG7154358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MK16"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040242">
        <property type="entry name" value="TPRG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31108:SF1">
        <property type="entry name" value="HSAC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31108">
        <property type="entry name" value="TUMOR PROTEIN P63-REGULATED GENE 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSac2" evidence="3">
        <location>
            <begin position="69"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7154358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="274" mass="31132" checksum="CEA468C15E169306" modified="2022-05-25" version="1">MFPLMISEVQRSAWTLPQDNRREVSAPTVTTPPTGLSRSFYQQPPIGRPRRASWHADTGSEPAIDEFFSVRVGALEQAVEECQHLTDLETDGAIKGAWLLTEINHWDIEKERVVILCELSLLVVKYDFIALRHIEFTRICLTSLENLQIGELTYPSHSLVPARNMQGFRVTWNNGHQISFAQKWNPWSRDIPYTTFTSHPLYWYTGCENSTYDAKSLAKELKLAIENMLDRPDTAATCSVSQSPIVIENYVGIASLLHNATELGFFKLRGKVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ML30</accession>
    <name>A0A8J5ML30_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041937">
        <property type="protein sequence ID" value="KAG7155346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ML30"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="220" mass="25231" checksum="E09A983982CD8A90" modified="2022-05-25" version="1" fragment="single">ILPYFGRNPIIFWGKILTYSATESYPILVRNRTLFWGRNLPSSAAGSYRILGKNPTVFRDVFLQYFGTQSYHLLWHNPTVFWSELLPFSVAESYCLLGRILTDFSGGILPSLGMKSYRLLGRNPTAESCRLLGQNPTVFWAESYRILGRNPTRNLRQKPTIFWGRILPYSGEKSYHLLGRNLTYSGSESYGILGQNSTGVNITGRTLLQRHFRLEDEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ML75</accession>
    <name>A0A8J5ML75_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hermansky-Pudlak syndrome 1 protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Hps1-L2</name>
        <name evidence="4" type="ORF">Hamer_G023798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041414">
        <property type="protein sequence ID" value="KAG7155509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ML75"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031085">
        <property type="term" value="C:BLOC-3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026053">
        <property type="entry name" value="HPS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12761:SF1">
        <property type="entry name" value="BLOC-3 COMPLEX MEMBER HPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12761">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="2">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="3">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7155509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="331" mass="36600" checksum="70DBD28B6CD0CC70" modified="2022-05-25" version="1">MLAVLIFDQLNDVVYLRCDHKFVGHVRSMAASQGLLSEAVVDPDQVAQLDPNIVVQLFSPLVTSQRIMTTQFNNPYTSVSCQDGTTVVFKEYAGYLFVGVGHQEESHLQRIISITIRIVQLIVGPCVTTLKKSDEKSSLLDNLLEAWQTLYAKEQSYLVEAVERLVVNAELSAAAVKALAAVVDKLKSAKDLTPCHALFFVRNKLLALYSSRSAQELSASDVLFLNLLVEASQVKSSDYMEDISPKNIAEIPDEKKEDDGIELDTSDSGEFYSIPNTPSLGRHNSHGEEEPEGKIRSCVLLLRTEMCQLTPHLVHYETLSDGLSLVIVSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLT2</accession>
    <name>A0A8J5MLT2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neuronal pentraxin-2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Nptx2-L2</name>
        <name evidence="8" type="ORF">Hamer_G012076</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLT2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035250939" evidence="6">
        <location>
            <begin position="18"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="7">
        <location>
            <begin position="19"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7155932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="716" mass="81343" checksum="0E27A8BAD29FC54A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MM63</accession>
    <name>A0A8J5MM63_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Tm9sf2-L</name>
        <name evidence="8" type="ORF">Hamer_G006521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MM63"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF176">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="591"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7156546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="723" mass="81986" checksum="E2D88BC4FC0231D7" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MN81</accession>
    <name>A0A8J5MN81_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G028042</name>
        <name evidence="2" type="ORF">Hamer_G028136</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037183">
        <property type="protein sequence ID" value="KAG7157624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010002179">
        <property type="protein sequence ID" value="KAG7177479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MN81"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="120" mass="13745" checksum="C9AE4E7651EC8754" modified="2022-05-25" version="1">MEKVDIVAARNKYLRYIQKNRESSNPRPEVYLDETWINQNQCVERCWTVNDGSAGPKLKSGRGARFIIVHAGGRQGFIPGALLMFRSKNGAKGDYHDSMDHERFKAWFKEQLLQNIQGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPF3</accession>
    <name>A0A8J5MPF3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPF3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035275936" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19380" checksum="85B760CE6D204328" modified="2022-05-25" version="1" fragment="single">MDNTATVLKAVVATIWLLGVAHLISATTYNECKFNKLPETKDQGTLYTFEDKKLKGWIRTVGTAVLNLSVGNDVHLSGTIGNSSDIKLDKWNQIVIEQIVTMGTHIQSASLTIRNGIQVKSNFLEIVCFPQARVQRSGGPPALLMTSWMTTLFPPTVDLQSSHKKMTHPCVGAKSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQ90</accession>
    <name>A0A8J5MQ90_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trimethyllysine dioxygenase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cbs-1-L</name>
        <name evidence="2" type="ORF">Hamer_G024188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032273">
        <property type="protein sequence ID" value="KAG7159771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQ90"/>
    <dbReference type="OrthoDB" id="6341042at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="1">
        <location>
            <begin position="63"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="153" mass="16690" checksum="5F26CFD73AE70AEF" modified="2022-05-25" version="1">MSSQRYARALLSGAAALRNTAVYQGQRNTHRCAHSRSLTLATAARQQLASAEAPRPGSGVISASTGSDALQITFCDGRRSEIPYSWLRDNCQCHKCSSCTSLTQPVNTEFELGAHPEIIQSNVFGVVVDWSDGHISKYPGEWLHQVAHTVYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSH6</accession>
    <name>A0A8J5MSH6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Y+L amino acid transporter 2-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Slc7a6-L3</name>
        <name evidence="6" type="ORF">Hamer_G008071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSH6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000056">
        <property type="entry name" value="Y+L amino acid transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF531">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7162515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="177" mass="19484" checksum="1044B41D5164D9F0" modified="2022-05-25" version="1">MTEARNDYKEVPMKEADEIKKDDEVVGLKPKMTLFNGITVIVGSIIGSGIFISPTGVLKNTGSVGMSLIVWIASGVFSMVGAYCYAELGCMIQKTGADYAYIMVTFGPFLAFMRLWVECIIVRPCSQTIVALTFSEYIMKPFFPTCMPPDVSGRLLAAVCIRKYTCVTSGRFSRHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTZ8</accession>
    <name>A0A8J5MTZ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative myb-like protein X-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mybX-L1</name>
        <name evidence="3" type="ORF">Hamer_G002766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTZ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7163566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="730" mass="82695" checksum="7B851B4A64F40B50" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU82</accession>
    <name>A0A8J5MU82_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Sodium/potassium/calcium exchanger Nckx30C-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Nckx30C-L1</name>
        <name evidence="19" type="ORF">Hamer_G002675</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU82"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000009">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF72">
        <property type="entry name" value="SODIUM_POTASSIUM_CALCIUM EXCHANGER NCKX30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="18">
        <location>
            <begin position="62"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG7163492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="278" mass="30480" checksum="3A75B682A7C1F0CD" modified="2022-05-25" version="1">MCPSCGYVLQGDGDDEDETKPIDLRWPDTCRKRITYIVVAPLIIPLWITLPDTRTPRGKRFFFVTFIGSILWIAAFSYLMVWWASLVGEVINIPPEVMGLTILAAGTSVPDLITSVIVARKGFGDMAVSSSVGSNLFDVTCGLPIPWLLFALVQVIKNVLNDVENPASIDPIVVNSGGMACSIMMLFCMLMFVIISIACSKWKMNKGLGTTMFVLYFIFVIVICDIHALSITVSTTTTATTTTTIIPQTLARRLAAVDLNVTGLGLVLFVRESNRSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MV49</accession>
    <name>A0A8J5MV49_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 25 member 46-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Slc25a46-L</name>
        <name evidence="9" type="ORF">Hamer_G004897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MV49"/>
    <dbReference type="OrthoDB" id="2403262at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090149">
        <property type="term" value="P:mitochondrial membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039158">
        <property type="entry name" value="SLC25A46"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21252:SF2">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN SLC25A46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21252">
        <property type="entry name" value="TB1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="294"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7165113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="495" mass="55028" checksum="DB6FBE29BE2A6AFD" modified="2022-05-25" version="1">MAGLDDYQFFSNLRERDTPFWQKSYEDRDKPMDTTDFYRRPTEFPQNLLNPAHSSPQTMKPVMLKPLDPDVDKGNDIQMEKYGELSINLVSLCAENLLSHPFIVVKRQCQVNVDSQRYHVLPITLVPALIHMQGCQGFSAFWKGLGSVLTVRGVTMALEDFISKFTPWPKEISPHSSPKTIGQHLILKCSALALITPFYSASLVETVQSEIASERPGVLDVFKEGLTRLLSFTQPQTGRMLPVWLLIVPTVSHGILQYLIGNAVSTITSQILRRYHRQDQQKQGAVSKDSGSFLDASVRLQSAFIGHLVSDVVLYPLETILHRLHMQGTRTIVDSLDVGYEVKPILTRYEGFFDCLHTTVQEEGVLGLFKGFGALCIQYALYGAVLKFAQVIIREVTLALVPPKPKPKTQDLVAPLTPSAPYTPISAIHPGIASLHSSPLNSSRHGSPRSGPYSNPTPAGGSRGSSIYASPGRRLQEVDLRAEMERHKINLSLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVV6</accession>
    <name>A0A8J5MVV6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G013074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024020">
        <property type="protein sequence ID" value="KAG7165576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVV6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="94" mass="11043" checksum="16F3053B21D688F9" modified="2022-05-25" version="1" fragment="single">MRSLCAAWRPLWPECVLQRDFEGFKELEEEAVVHEISGEDEDKEESRIIPAKDLKDVFFCWSKLSKLAEDYHPDVGSVEKAISVFNDNVMNYFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWY8</accession>
    <name>A0A8J5MWY8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Paired amphipathic helix protein Sin3a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Histone deacetylase complex subunit Sin3a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Transcriptional corepressor Sin3a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Sin3a-L</name>
        <name evidence="21" type="ORF">Hamer_G013063</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression. Required for cortical neuron differentiation and callosal axon elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with ARID4B, BRMS1L, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ and TOPORS. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase. Interacts with BAZ2A, MXD1, MXD3, MXD4, MBD2, DACH1, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1, SMYD2, and SUDS3. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with TET1; the interaction recruits SIN3A to gene promoters. The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A. Interacts with KLF11. Interacts with PPHLN1. Found in a complex with YY1, GON4L and HDAC1. Interacts (via PAH2) with FOXK1. Interacts with FOXK2. Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1. Interacts with SINHCAF. Interacts with SPHK2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000004">
        <property type="entry name" value="Paired amphipathic helix protein Sin3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="20">
        <location>
            <begin position="730"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="279"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="542"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1007"/>
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            <dbReference type="EMBL" id="KAG7167585.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
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                <person name="Kohn A.B."/>
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                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Greenwood S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
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            <dbReference type="EMBL" id="KAG7169851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N089</accession>
    <name>A0A8J5N089_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014835">
        <property type="protein sequence ID" value="KAG7170209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N089"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035241053" evidence="3">
        <location>
            <begin position="22"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7170209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="175" mass="18075" checksum="FBF18ABF96534614" modified="2022-05-25" version="1">MQWRALLVLVLVAVLAVYVNAAPAAEAEAEPCCGGRRRGGGGFGGGGGFGGGLGGDVVDLEAVLEEEEVTASKEELPAGGRTHLLEGGPTCWREDPPAGGRTHLLERGPACMKLLGYDDKWTFLLMVVLVAIMAVYVNAEAEAEAEPCCGRRRDGGGGFGGGGSFGGGRRDKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1P7</accession>
    <name>A0A8J5N1P7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pseudohemocyanin-2-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Phc2-L4</name>
        <name evidence="3" type="ORF">Hamer_G014671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tyrosinase family. Hemocyanin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1P7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF5">
        <property type="entry name" value="FAT-BODY PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="2">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7171545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="650" mass="75876" checksum="DF68B3429BCA3B27" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N390</accession>
    <name>A0A8J5N390_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G009659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N390"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="80" mass="9186" checksum="83D0733C50CCC302" modified="2022-05-25" version="1">MTAWQDETSRKLQDDIANDTWVTGKYCNPNSMENAGTFTQPMKRAINWEEKGVLEKEHQTLLIKPQIAHFPGHQAVYAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3Q6</accession>
    <name>A0A8J5N3Q6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cuticle protein 19.8-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Cu198-L2</name>
        <name evidence="2" type="ORF">Hamer_G030346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010398">
        <property type="protein sequence ID" value="KAG7172843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3Q6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="126" mass="14488" checksum="1A235229C6C4ECEE" modified="2022-05-25" version="1" fragment="single">DPENMWAYEVDARSTGDKKSAREERRGDVVVGQYSAMDPDGSLCVVDSSVAPDTDFQATNQLSTRDQFQNQQSRPDQFQSQQSRPDQFQNQLSTSDQFQNQLSTSDQFQNQQSRRDQFQNQQSRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3W4</accession>
    <name>A0A8J5N3W4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TOM1-like protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Tom1l2-L</name>
        <name evidence="7" type="ORF">Hamer_G017876</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TOM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010216">
        <property type="protein sequence ID" value="KAG7172897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3W4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14233">
        <property type="entry name" value="GAT_TOM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03565">
        <property type="entry name" value="VHS_Tom1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014645">
        <property type="entry name" value="TOM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856:SF137">
        <property type="entry name" value="GH05942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856">
        <property type="entry name" value="VHS DOMAIN CONTAINING PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036948">
        <property type="entry name" value="TOM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="5">
        <location>
            <begin position="34"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="6">
        <location>
            <begin position="221"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7172897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="420" mass="46472" checksum="FFD2EE13B1041C95" modified="2022-05-25" version="1" fragment="single">MRAIQKYRRITNIPTDQESSVMASSSLMQKLEQATAETLPSEDWGLNLEVCDLINESEDGPRDAIKAIRKRLATQPKNYTVVMYTLTLLESCVKNCGKRFHILACSKDFVQDLVKLIGPKNEPPAAIQEKVLLLIQAWADAFRHQPELSGVSQVYAELKHKGVEFPMTNLDTMAPIITPQRTAAPEPRPPRVPPGNATSPRRQTAHQPATTPAAPVSLTAEQRAKLHSELDVVESNAKVLGEMLGELSPGKEHQDDVQLLQELHATCRAMQQRVVELVGRVSDDILTADLLRINDDLNNLFLRYDRHMNKVKGISSPTKSPQQQPTPQPPQLPPPQRPTQQEVSLIDLADEAPSAQLATLTVGNSPKAKKNEDADFDMFAQSRTATYENNKTSGSTYLDNSEMDVTSVSLGRAAQLRNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3W9</accession>
    <name>A0A8J5N3W9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Elov-L6</name>
        <name evidence="11" type="ORF">Hamer_G006859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3W9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF167">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7172644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="413" mass="46422" checksum="A233A2E169EE922D" modified="2022-05-25" version="1">MEDSGLVASVTVMTIEKRYHVMGRMSAMVAYGRWSHGGRDPADNGKYRDVNVLMVTKMITVGAQVTECNGGEQCGIVSPLVILVAGELTYLLVIYGNMAPSTSTVGPIPTQPQLKQEKKEPVTTVGVSAKWGIIMTLLNLVYGHLLVATQLPPDPRQDSWLLMKSPLPTYFLSLGYVIGVTWLGPKFMENRKPISGLRPVMVAYNTFQVVYSSWLVYETCLGGWFTNYSFRCQICDFSNDPQAIRMLHASYWYYFSKFVDFFDTVFFVLNKKHEHISLLHVVHHSLMPVSMWYGVRYQPGGHSTFMGLLNSFVHVVMYLYYLLAAMGPRVRPFLWWKKYLTSLQMVQFVAVMLHAVQEKEQSSVSIARESRGVRGGTLSGVSRRGVPNGVAEAACKTMEMCENMALRSRLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3Z6</accession>
    <name>A0A8J5N3Z6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Secreted frizzled-related protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Sfrp4-L</name>
        <name evidence="15" type="ORF">Hamer_G007022</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the secreted frizzled-related protein (sFRP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3Z6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000005">
        <property type="entry name" value="secreted frizzled-related protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF96">
        <property type="entry name" value="SECRETED FRIZZLED-RELATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="14">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="13">
        <location>
            <begin position="126"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="126"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="134"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7172782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="303" mass="33419" checksum="3DB043EB2092AD2D" modified="2022-05-25" version="1">MDKMESLLQDWIQDQTRCRLPLSSIWMKLKAKSSDNSGSKTSSTFRASPGWILQFKNFDYLHNLLLPGNDQLPCLPCFSSSHLKHLKPSMTTLFTSTHAPGVLWAAVWAVLCSMVGAVWGQFGPQCEEIKIPMCQKMPYNLTRLPNLLHHSTQENAQLAMDQFEVAFGMDEMFRPAGVLCSMYAPICTVGFVHEAIPPCRSVCEAAKQGCEPLLAKFDIAWPANLQCDHLPVYDRSVCITPQAIISSGEADTQLVCYGEADIQPVLAVGPTSVLTWEADNQCYCGRLTSSAREYTSTSAIVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N590</accession>
    <name>A0A8J5N590_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009571">
        <property type="protein sequence ID" value="KAG7173502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N590"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053121">
        <property type="entry name" value="Spore_Coat_Assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35365">
        <property type="entry name" value="LP04239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35365:SF18">
        <property type="entry name" value="MUCIN-19-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="384" mass="40364" checksum="635C1152C5AA819F" modified="2022-05-25" version="1" fragment="single">MAAVNTCQYLSAAVNTCQHLSAVVNTCQHLSAAINTCQHLSAAVNTCQHLSAAVNTCQHLSAAVNTCQHLSAPIKTCQHLSAAVNTCQHLSTALPSTPANTYQLSSTPANTYQLPSTPTNTYQLPVNTCQHSSAAVNTCQHLSAVVNTCQHLSAAINTCQHLSAAVNTCQHLSAAVNTCQHLSAAVNTCQHLSAPINTCQHLSAAVNTCQHLSAAVNTCQHLSAPIKTCQHLSAAVNTCQHLSTAVNTCQHLSAAINTCQHLISSDAVNTCHLSDALPSTPANTYQLSSTPANTYQLSSAPANTYHMPSTPANTYQLPSTPANTYQLSSTPANTYQMPSTPANTYQMPLTAANTYQLPSTPANTYQLSSTPANTYQMPSTPSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N744</accession>
    <name>A0A8J5N744_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lactosylceramide 4-alpha-galactosyltransferase-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">A4galt-L3</name>
        <name evidence="1" type="ORF">Hamer_G003296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N744"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="178" mass="20335" checksum="5DA94849B62F9893" modified="2022-05-25" version="1" fragment="single">MRQWRRYIALRVAGAFILLVCLLYTSRPPEGKRPPPPSPSQGDVQVDKDEQVNDPLSFCRTPSGPQTPHQHFLKLVDIFSLKEAQQEGVNNILLVESSCAVNPNLRVWCALESLARQNPQAVVWYVMTSQVVDLRQVVAGRLLEHYHNLRVVTVDLRQVFYNTPLMDLYTSTAWNHNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7Q2</accession>
    <name>A0A8J5N7Q2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G015737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007499">
        <property type="protein sequence ID" value="KAG7174609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7Q2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="107" mass="11573" checksum="BC028A81E583C55E" modified="2022-05-25" version="1">MRQEPYTPDQFIVGDVPAWQLLCGGCIKTSLPGPPPVSLPSSTLTPKYIWTRAGWLPYTPGECVTGLRSAAHVICCTILMDAFVGSLQTVTIGQQYKAELTDVFVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7R6</accession>
    <name>A0A8J5N7R6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras association domain-containing protein 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rassf10-L</name>
        <name evidence="4" type="ORF">Hamer_G015757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007499">
        <property type="protein sequence ID" value="KAG7174624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7R6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16123">
        <property type="entry name" value="RA_RASSF7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033593">
        <property type="entry name" value="N-RASSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048945">
        <property type="entry name" value="RASSF8/10_RA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286:SF1">
        <property type="entry name" value="FI07216P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21712">
        <property type="entry name" value="RASSF8-10_RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="96"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="538"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7174624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="622" mass="69380" checksum="B2CA5C69767E2212" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N846</accession>
    <name>A0A8J5N846_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G015313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7175090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N846"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="66" mass="7957" checksum="678B1B84ADEC60A9" modified="2022-05-25" version="1">MNRLFLLHWSRGRAHRAHLHRWRKRLRSRGRPPARTTHTCGSALPEIWKLNLQPDPHSHMFPFSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8S6</accession>
    <name>A0A8J5N8S6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">P4HA2-L3</name>
        <name evidence="14" type="ORF">Hamer_G016978</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7176015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8S6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000011">
        <property type="entry name" value="Prolyl alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="13">
        <location>
            <begin position="344"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7176015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="505" mass="57208" checksum="03670A214E1469EC" modified="2022-05-25" version="1" fragment="single">YLQDYEQVSAEGPATDEVMMERLAGNPVHAFHLMKRITVDWRHIEDQAKVDHWRGVEEAMRNVGVGVKLPREEDLHGAAQALIRLHDVYNLNMTQLVRGNVWGVESTAEMTSQDCLFMGKHSFNLGLYPRAIQWFEEAYTLAGEESNTTVTQEQVNMFLNTAIKAYDENIASQVDNEEEEVHKEDFSASLRDDHNKKKNEKVPKYRLGVDLTPPEDAANFQALCRGEQLLNESYQATLSCFYDSRDDHYLKLMPVKVERHHWHPELLTFHDVLTDNEIALIKLLAQPVLARAMVQGAQGKGNTISNTRTSKVGWLDDSVHPLVAKIGDRIQRISKLSTNMASEDAELLQVANYGIGGHYNPHHDYLLVDKTEKELLHNIHPRELVMGDRIATFMFYLSDVTRGGATAFPRLGTAVWPSKGSAAFWFNLKKSGHADIATLHGACPVVHGSKWGIKQQVDQRARTILEEEMWNVPGRIVEDVKKASVHLRLKGFRPSTSKRLPSIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9M3</accession>
    <name>A0A8J5N9M3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Early growth response protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">EGR1-L</name>
        <name evidence="12" type="ORF">Hamer_G001367</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGR C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9M3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021839">
        <property type="entry name" value="EGR1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11914">
        <property type="entry name" value="DUF3432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7175309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="162" mass="17708" checksum="6C1A293E6C134B1B" modified="2022-05-25" version="1" fragment="single">INPVCVSSINHVCVSNINHVCVSSINHVCVSSINHVCVSSINHVCVSSINHVCVSSINHVCVSILTMYVSLVLTMYVSLELTMYVSLVLTMYVSLVLTMYVSPVLTMYVSLVLTMYVSPVLTMYVSPVLTMYVSPVLTMYVSPVLTMCVSPVLTMYVSPVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA12</accession>
    <name>A0A8J5NA12_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G015550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA12"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="145" mass="16165" checksum="37B0B5B229A12D4E" modified="2022-05-25" version="1">MFLIPSAAASTTCWSSEDNVSTSTVTPPTDTNASMCSFVPALEEETVKRMEGLLVSSYPLKRNTKVRTFASAKVVKVSEDRTMLSQRFLVVYQSGDFRLDPVIDYELCPYPLSLFEAKYFMCKANKRPLAEAIRNSASVELDRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAE0</accession>
    <name>A0A8J5NAE0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Acetylcholine receptor subunit alpha-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Ara1-L3</name>
        <name evidence="19" type="ORF">Hamer_G016985</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7176021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAE0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098655">
        <property type="term" value="P:monoatomic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000022">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit alpha4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="18">
        <location>
            <begin position="81"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG7176021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="184" mass="21434" checksum="1E5A3A726713267A" modified="2022-05-25" version="1">MEPNRVMIRTCNGHEVQDSFYRPQFDDLMYKHNDHPLPYDTPLPRGPRNDFSPMTDGPFSTTCRIHGASNIHDDTYTLENSDKSPTFRPFQHNLPHCSPEVHRTCWCVNFIAEHTRLKEDSTKVKEDWKYVAMVLDRLFLWIFTLAVLVGTAGIILQAPSLYDDRTPLDKEISDVYRATHRLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAH7</accession>
    <name>A0A8J5NAH7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cuticle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G000173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAH7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035180287" evidence="2">
        <location>
            <begin position="16"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7176961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="105" mass="11539" checksum="89582A732506172B" modified="2022-05-25" version="1">MKLILLACLVALAAAAPRPDEDEAKILVDERQATADGNFNYRYETENGISEDRLGTPGSEGQSNMQGTFRAESPHLPQPHPLPAHAIEQIRVAEEQRAQGITFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAL4</accession>
    <name>A0A8J5NAL4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate receptor-like 49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Glrk-L49</name>
        <name evidence="16" type="ORF">Hamer_G016971</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7176008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAL4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="10"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7176008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="355" mass="39771" checksum="D3376A459B6A47AD" modified="2022-05-25" version="1">MTAASPQPLKIAVGTWGPWAIVSRREDGAIVVEGTMRRILEMFTQAMNLDYQLVLAPDGKWGNLNTSGYWSGLMGLIQRKEVEIALGPFIVTSEREELCDFSLPLYIENSAIVYQRPALESSSWVPAGNGSRGVVATWFMASLVFFTSYGSTLTSLLTVPRVNVPIDSVADLVAQDTIRWGLAPGYMWYQYFRDSEDDVRRQVFERTALVPTGCYRSRSQVIYGDLARFCDVTTILKIMSLDFSMNGKCHLYMAKETVHSNFPVSVAFQKNSPHLPRANKILIQLQESGILGKWRSEHINNATQCLRHPSKDRPPGLYPLTLHDLSGPFLLLAVGVMSALVCFLGETLGFRFWQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NB30</accession>
    <name>A0A8J5NB30_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003958">
        <property type="protein sequence ID" value="KAG7176168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NB30"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7176168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="428" mass="48335" checksum="3D45B5BA63C9D814" modified="2022-05-25" version="1" fragment="single">EEEQEAEGEEGEEEQGDSNEEEQDEEWGGKRKRKKSKKRKSSRGERGRKKRKKKDESESEGNMKKMASTQTTRRRAEVRRGRRYLCQIDDAGWCQSVEDGVRGGGWCQCVEDGVRVWRMVSGVEDGVRVWRMVSQCEDGVTVWRMVSECEDGSECGGWCQSVEDGVRGGGWCQSVEDGVSGGLCQSVEDGSVCGGWCQSVEDGVRVWRMVSQCEDGVTVEDGVSVWRMVSQCGGWCHSVEDCVTVWRMVSRVEDGVRGGGWCQSVEDGVTVWRMVSVCGGWCQCVRMVSECGGWCQSVEDGVTVWRMVSYAHTIIVVNLTADYGPQYLAEVVQRLQCGDPSPVINWLQQHGLLRRQMTCHCCHNPMTWTKHSRSKDGSAWRCKTRGCVKYKLTCRYEPVASKSRMSLQKWVHAIYLWSERVGSQRQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NC52</accession>
    <name>A0A8J5NC52_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 13 member 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Slc13A2-L</name>
        <name evidence="7" type="ORF">Hamer_G003794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NC52"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015556">
        <property type="term" value="F:C4-dicarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7178041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="365" mass="39659" checksum="B565C9B56E6EE20F" modified="2022-05-25" version="1" fragment="single">GVVFQAARCGYVITIMAVYWMTEALPLAITALIPVFAFPLLGILSTGSVCIVYMKETNMMFLGGLTVAIAVEHCNLHRRIALGVILLVGQSPRRLMAGFMLTTMFLSMWISNTATTAMMVPIVDAILTELYSTHDGGETGTDGMDLSVYPPHQSQLELVNNSEPVSSVHPGSECKNGKLEKVIEDTKVDQEDKKPEGHTGLTPIPPNEECRALRDMCFLATAYSANLGGTGSLTGTGPNLVVKGVLARDRKKDPVVRNTRVMLLMSVMYAANIGGTGVLTGSGTNLVLKGFLQSCRKTKVIQEPTNDRKAAVKKLVLSKYRELGPMAFQEVVVLTLFIILVLLWLFRAPEFIPGWSDLFTDAFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5THC6</accession>
    <name>A0A8J5THC6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Oatp74D-L2</name>
        <name evidence="11" type="ORF">Hamer_G009687</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5THC6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17336">
        <property type="entry name" value="MFS_SLCO_OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF76">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="464"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="686"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7172322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="717" mass="79598" checksum="B562096FE0BC4466" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLA1</accession>
    <name>A0A8J5TLA1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Notchless protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nle1-L</name>
        <name evidence="8" type="ORF">Hamer_G015783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007499">
        <property type="protein sequence ID" value="KAG7174648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLA1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="7">
        <location>
            <begin position="38"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="251"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="378"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="420"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7174648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="495" mass="54935" checksum="3E70E53923D9861C" modified="2022-05-25" version="1">MEEGSKRDCEEDGHSVPEKIMRMDATDTVESNENRANVLAQFQSESGDTAGPPIELPLTLARDKLQQILNVLLKQEDHTPYSFYVNEKEVTTDLNGVVNSSTSEEKVMTILYQPQAVFRVRAVTRCTSSLPGHAEAVLSASFSPDGQHLASGSGDTTVRFWDINTETPHFTCKGHRHWVLVTAWSPDGERLASGCKSGQIFIWDPKTGKQTGRALTGHKQWVTALCWEPLHLTNNGESTRLASAGKDGDVLTNHLQSVTALRWSGEGLLYSASQDRTIKVWRASDGVMCRTLQGHGHWVNTLALNTDYVLRTGACDPQALMKPSPEVTAPEKRLSYAEKRYKEVLAVAGGVERLASGSDDFTIFLWEPAKDRKPIERMTGHQQLVNDVKFSPNTRIIASASFDKSIRLWNGFTGKFIAVLRGHVNGVYQIAWSADSRLLVSGSKDSTLKVWNMSTKKIEMDLPGHADEVFTVDWSPDGQRVVSGGKDKILKIWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TMX2</accession>
    <name>A0A8J5TMX2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G028267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006007">
        <property type="protein sequence ID" value="KAG7175472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TMX2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="135" mass="15060" checksum="C4397FA104B8C4DB" modified="2022-05-25" version="1" fragment="single">VLLTVGVMAVTTFAEEKGNGRSDLVKYTINPGGQVLIKSPENLTHSEYVVECHKVDFTTLKLVPGVTTFPDCDRERFIISTNNTRDIEVCANNTWQDLQNTGTSNGWMKIKYQLLQGVRSTAFQFVVKCSRVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TRH7</accession>
    <name>A0A8J5TRH7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G015453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TRH7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="79" mass="9560" checksum="87F801A64D4BF1CB" modified="2022-05-25" version="1" fragment="single">MVRFCPRRWKESAPEDGRILQHNTVGYRLRRWKESTTEDEYGRILQQNAEGFWARIWYDSALEDGRNPPMKMVRFCPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TV28</accession>
    <name>A0A8J5TV28_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 26-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Zfp26-L5</name>
        <name evidence="10" type="ORF">Hamer_G008425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000417">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1048"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1168"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1081"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1169"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1198"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7177753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1367" mass="154094" checksum="A3E562CDEB3A824B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TWD4</accession>
    <name>A0A8J5TWD4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000506">
        <property type="protein sequence ID" value="KAG7178248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TWD4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="8240" checksum="4A5529FED45471FA" modified="2022-05-25" version="1">MTRNHIHIPTKRPTSRQTDPPADKQTHQQTNRPTSRQTDPPADKQTHQQTNRPTSRQTDPPADKQTDKYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J7W3</accession>
    <name>A0A8J5J7W3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Glutamate receptor-like 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Glrk-L50</name>
        <name evidence="14" type="ORF">Hamer_G017670</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046276">
        <property type="protein sequence ID" value="KAG7153856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J7W3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF38">
        <property type="entry name" value="IONOTROPIC RECEPTOR 100A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="13">
        <location>
            <begin position="107"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7153856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="252" mass="28004" checksum="443CE4F44B7C25A3" modified="2022-05-25" version="1" fragment="single">MLLIHAQLYKQWGATAAIHLAGSFRGQRRVHQAGSRHHPLVYGRDTVCFTTRCVYLPQTTEGSVLMVRLLEEVMEDPEVLRDVRDNPTTFRFKEGALMTVTTVHRPPHVTLINHQDGTYSITGPLAQLMDTVATSLNFTYRVVTPPDGTFGTATPNSSWSGMIGQVTRKEAMIALAPYATTWERYQAVDYLHHITHDYASMLNGKGRPEINPWGFVFPLQPLVWAALLAALVVAWLAIVLMGTKPVGSGHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J9A5</accession>
    <name>A0A8J5J9A5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aralkylamine N-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">AANAT1-L</name>
        <name evidence="15" type="ORF">Hamer_G019669</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dopamine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecanoyl)-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51380"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31883"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:51381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dopamine + acetyl-CoA = N-acetyldopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51388"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:125678"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:51389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dopamine + hexadecanoyl-CoA = N-hexadecanoyl-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51376"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:134058"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:51377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>serotonin + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51396"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:132255"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:51397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>serotonin + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51392"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:134064"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:51393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>serotonin + acetyl-CoA = N-acetylserotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25217"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17697"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
            <dbReference type="EC" id="2.3.1.87"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:25218"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>serotonin + hexadecanoyl-CoA = N-hexadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51384"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:134059"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:51385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>serotonin + octadecanoyl-CoA = N-octadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:134065"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:51401"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetyltransferase family. AANAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.87" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010043654">
        <property type="protein sequence ID" value="KAG7154857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J9A5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000046">
        <property type="entry name" value="Dopamine N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7154857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="302" mass="33517" checksum="0EC6F87F53988B1B" modified="2022-05-25" version="1">MSPPLGTRRKDGASGEGSEGSAPGEEDPLAQTTAGQEAQQQLEQSQQKQEQQQVEPEEPELPSEPELPPDVLHKHDENIVFKVLTQEYSDAAVDLLCNHFFKDEPLGKALYLDSPREVDHWLSKVLPHMISHGVSVMAIDESANGRLVGVAINSIKRRGDAPGPDDFLAWIDPKKDPKMFKIISFLTQLASDIDFFSQYSVEKFFNFELLNVDKSYGGRGIASMLVQQSCNVARTQGFTCLVAETTGIFSAKIFGRHTFKTIREVQYSQFRQNGRIAFPNTGIHTSARVSVKILEPLVPNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JBK7</accession>
    <name>A0A8J5JBK7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043233">
        <property type="protein sequence ID" value="KAG7155100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JBK7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="69" mass="7919" checksum="3BF28CC86AA79170" modified="2022-05-25" version="1">MMSAGVGYSNHKARRPHFRVTTPQEDEHIRQAAEENPFTNAVAIRDELQLNVFNEAVWRRLHEGGTHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JC90</accession>
    <name>A0A8J5JC90_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Angiopoietin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Angpt2-L</name>
        <name evidence="4" type="ORF">Hamer_G011992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JC90"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="371"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7155862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="592" mass="66690" checksum="23F427F683BFE3AF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCJ8</accession>
    <name>A0A8J5JCJ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G020917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042628">
        <property type="protein sequence ID" value="KAG7155191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCJ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="214" mass="23917" checksum="C95231C25147D88C" modified="2022-05-25" version="1">MMEPLRKMSERFYEMASPVLKPMMTAGQRFSERFQLPKRMSHLSERLNLGTMNDYISRTVDDESLPLVAGVALLGTLGLVGIAVAASSNVTIGKRSVDDPTLEFLDQLVEEVPMGEPTLLNRLEEYVPWADSRCSKRIFCDLMTYASTDFQYTIEKRLGLFLNLLNHGGREESSLKRTAADVMRAVHQRKCDLFTCGGDQVDSSQVLMGGSGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JDL9</accession>
    <name>A0A8J5JDL9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tensin-1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Tns1-L2</name>
        <name evidence="4" type="ORF">Hamer_G017629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046276">
        <property type="protein sequence ID" value="KAG7153820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JDL9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832:SF2">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832">
        <property type="entry name" value="SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="224"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7153820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="356" mass="38069" checksum="5EB6FB289E4A8FC6" modified="2022-05-25" version="1">MQAAAASPESSPSSKMRTPGSSAVASSPTHNLLGLQKPSSLPGLHSHPENDNIVHSPDSENSNSPSELNSSKRLADKPPLIKKLSVALESTLNLEEDLHPLVTSSSSPSPSCQTSCVTTSTSSSSTTSTAVVGYVNEKVSDSSVNSVLSADGQDQQDTDNKCRLSDDVKLKRISQISVSSSASSGVVGLDVSTSSTRSASPPPLPERSDSLTPPEEPHLKTAAWFQAGIPREIALEVLSHEPVGAFMVRESTSKPGCYALSLRVPRDFTVSGIAHYLIVKTNKGYKIKGFTKEFNTLTALITHHSVMPELLPCPLSLSRYNPTFTSDDQNRNDSNDDDPDYNTLSDFRKMMADLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JE29</accession>
    <name>A0A8J5JE29_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Viral IAP-associated factor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">viaf-L</name>
        <name evidence="3" type="ORF">Hamer_G022471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042381">
        <property type="protein sequence ID" value="KAG7155249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JE29"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="2">
        <location>
            <begin position="96"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7155249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="300" mass="33892" checksum="C399B228E4816EE0" modified="2022-05-25" version="1">MAGHDWEDKVATNAITTTITTATSTTPNPSTPLNKALYNTPSILHQQGTLHLLSLAAKHSKNTEEDTEWNDILRQKGILPPKEPEVTEEALTEMLEQTIQEKQSADARLGKLSLDELDELEDDEDEVILLEYRRKRIAEMKAEAELCKFGEVGEISAQDYVEKVNSAGPGIWVFLHLYKQGIPLCDLINQHISRLAAKYPQVKFLKSISTTCIPNFQDRNLPAIFVYFEGQLKRQFIGVAEVGGDRVKYEELEWILSRTGGFKTDLESDPRGPRVKDVLLNSIRGYKDDDDENDSDEGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JE96</accession>
    <name>A0A8J5JE96_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L27, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Mrpl27-L</name>
        <name evidence="10" type="ORF">Hamer_G015620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010043233">
        <property type="protein sequence ID" value="KAG7155021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JE96"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000031">
        <property type="entry name" value="39S ribosomal protein L27, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7155021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="160" mass="17679" checksum="4B6E3BAA2BD89C39" modified="2022-05-25" version="1">MAASLVKKIMSFSISGISGGPGGSSILSNNTVGLLTSVRNASKKSGGSSRNKKGRARGKRRGIKKADGLWVSQGTILVRQLGLDYLPGLNVGIGRDRTLFAIEHGRVMMTTEKVNPNWDHSFVRRFYADLQNQEDVPIYKTYFHILTDPQKQNFKLVDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEJ8</accession>
    <name>A0A8J5JEJ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G005990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEJ8"/>
    <dbReference type="OrthoDB" id="6358613at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="133" mass="14647" checksum="4C37FDCCB837EF41" modified="2022-05-25" version="1">MTTDDAAPLSANHTASSSSTNETLGSFRSLKILKSDLASIFNQVDVSTVGKVLLLTVFVLLIYDLLVYLLASISSRKRLLVTPWLTQILANSWDDLNQRGSFARSHDAIGPLLKSLAHTAAKYEGRWEKSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGA7</accession>
    <name>A0A8J5JGA7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G009970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGA7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="201" mass="22703" checksum="0D0AB18559DEDC29" modified="2022-05-25" version="1" fragment="single">WLLSTDSAAMPSDALMPLRVRHAPPMFVPPLWNVHDATMNNNARTNNICEGWNNKFFNLVGHYHPSIWRREEATVSTIIQQDAVGNPPQRRVRRRDVQLQERLRNFSSKVLLGGNKEFPTWPIAKSDSDGNYISESSQTTGLGEVIDSSPELESLITSPLHPRVQTSQEWANEPEIVIKRGRIVGIWVMGMSMSDNAKQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHM3</accession>
    <name>A0A8J5JHM3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Casein kinase I HRR25-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">HRR25-L3</name>
        <name evidence="2" type="ORF">Hamer_G029708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035246">
        <property type="protein sequence ID" value="KAG7158402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHM3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="188" mass="21235" checksum="CE1B43279CD314A4" modified="2022-05-25" version="1">MSEVKIQRKLDGAGGAPRIHAVCQEDSSVIMDYTGITYDKYINYATTRQKVHTLVKIAEALCEIHQKNIFHNDLKIDNITITVEEKDSTVHIIDFGKATDHEKYINRGKISRYWIAPEFASGGVTSAASDTYSFGQLVRDVRDYITDNGLILELFDKIVDMTTCEDPLHRVPLTEVVRVMNECLPIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JI26</accession>
    <name>A0A8J5JI26_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nucleolar and spindle-associated protein 1-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nusap1-b-L</name>
        <name evidence="13" type="ORF">Hamer_G020549</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NUSAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039068">
        <property type="protein sequence ID" value="KAG7156468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JI26"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040001">
        <property type="term" value="P:establishment of mitotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026756">
        <property type="entry name" value="NuSAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15874">
        <property type="entry name" value="NUCLEOLAR AND SPINDLE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15874:SF1">
        <property type="entry name" value="NUCLEOLAR AND SPINDLE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16006">
        <property type="entry name" value="NUSAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="96"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="224"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="415"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7156468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="639" mass="70863" checksum="88C032FFF00B8D7A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIP7</accession>
    <name>A0A8J5JIP7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G006149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIP7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="153" mass="17168" checksum="B9F4A5227CCB0856" modified="2022-05-25" version="1" fragment="single">FSLGFSPSELILGRNIRGPLKVLNENWVEEDETAKDRKFNVGGNVLLFLPIRKFPLQAKYQGPFEILSKIGDVNYIIAKLNVVCNTVTCDGVKEDELPKHDLGELKADIKLNNSDVLSDPSSKLCHLLQDQRSDVMCLLREFQPIFGDVPQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIS3</accession>
    <name>A0A8J5JIS3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Digestive cysteine proteinase 3-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LCP3-L4</name>
        <name evidence="10" type="ORF">Hamer_G017699</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046276">
        <property type="protein sequence ID" value="KAG7153879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIS3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000332">
        <property type="entry name" value="Cathepsin L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035316502" evidence="7">
        <location>
            <begin position="17"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="107"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7153879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="299" mass="32916" checksum="29002C828538692A" modified="2022-05-25" version="1">MKVTALFLCGLALATASPSWEHFKAQHGRKYVDAEEELFRQRVFQKNEQFIEDFNKKFERGEVTFNVAMNQFGDMTNEEFNAVMKGYKMGSRDEPKAVFTAKEGLPMAADVDWRTKGAVTPVKDQGQCGSCWAFSTTGSLEGQHFLKYGELVSLSEQQLVDCAGGIYFNQGCNGGWDKTCRFNANSIGATLVSHVDIAQGSETGLQQALSSVGPISVAIDASHFSFQFYHDGVYYEPNCSSTNLDHAVLAVGYGSEGSQDYWLVKNSWASTWGLQGYIKMARNRSNHCGVASAASYPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJ20</accession>
    <name>A0A8J5JJ20_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G021010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037948">
        <property type="protein sequence ID" value="KAG7157124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJ20"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="75" mass="8723" checksum="BA4BC7648AAFEC12" modified="2022-05-25" version="1">MTPFDDFVYLVNSILLGEEPTIEDFILLIGTFVAFIAFILWCCFPIVPKESNPPAQYDTQYTKYKKTDSPYDEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJN9</accession>
    <name>A0A8J5JJN9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G029390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037522">
        <property type="protein sequence ID" value="KAG7157278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJN9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="277" mass="31838" checksum="AAA9F71CA95F68ED" modified="2022-05-25" version="1" fragment="single">EGWLLVSGKFCATKCKEQRTQRRCIETKGFLEFVNQKLQITGCKTDVILRDDLYHKYKMYCKCRGLMPATIVNVGRTLAKKGVKSPSRIGGINGKGQKYGYTGIVFQPCMEVVPWHPYSAVYSMHSDSVISGKRKLEEQDQNEPKRAKITGEIIDPISTFLESFVSTSLDHNELVRQNDLFNEYREYCRQNGLERYNNIKLGRLMTARGFKPTVRVGKPNSQQYCYPGLKWTREAPSGNNYTNLKQQRCHPVCPDRVISEAKRYLLICLAIQFVNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMQ8</accession>
    <name>A0A8J5JMQ8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pro-resilin-like 87</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G016551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033762">
        <property type="protein sequence ID" value="KAG7159168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMQ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7159168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="161" mass="17937" checksum="1C2751B94C5440C2" modified="2022-05-25" version="1">MAVARPQNHPRQYYGSPGSDFVLVLCVVTMPVARPQNHPSEYYGSPVSNFVLVLCAATMTVARPQNRPNEYYSSTGPDTPAQYNFNWQVKDDPSGNDFGHEESRDGDNTQGSYYVLLPDGRLQRVTYTVNGNSGYVAEVTYEGEAQFPTYQSSYTPAPRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMR0</accession>
    <name>A0A8J5JMR0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cc8K15.2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029899">
        <property type="protein sequence ID" value="KAG7161112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMR0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="60165" checksum="F8938F2E11AAEFE8" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQI1</accession>
    <name>A0A8J5JQI1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA (Cytidine(32)/guanosine(34)-2'-O)-methyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FTSJ1-L</name>
        <name evidence="7" type="ORF">Hamer_G001746</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQI1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000220">
        <property type="entry name" value="CAMK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="6">
        <location>
            <begin position="18"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7160481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="213" mass="23526" checksum="0D06645FE0234DE6" modified="2022-05-25" version="1">MCFYCFHYRGAAADPSSVKIVAVDLQAMAPLPGVVQLQGDITKTSTAEAIIGHFQGDTAQLVVCDGAPDVTGLHDLDEYVQAQLLLAALNITTHVLTKGGIFVAKIFRGKDVTLLYSQLKIFFRHVTVTKPRSSRNSSIEAFVVCEDYSPPSGYTPTMVNPLLDLSYEGSWQELEGVNRVIVPFLACGDLFAYDSDMTYPLQVMYNDIFNYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQN5</accession>
    <name>A0A8J5JQN5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Glutamate receptor-like 86</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Glrk-L86</name>
        <name evidence="9" type="ORF">Hamer_G007862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQN5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7162346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="104" mass="12003" checksum="DDA2FFAB0368EDA5" modified="2022-05-25" version="1" fragment="single">KGAPYYRRFHQMVLRLTDAGIIQHWTDDVIARRVKENRAAAALDPIATLSNEKEMVLGMQHMQGAFYLLFLGCGLVILILLMEYIVQYHPRLNKTFAITTRPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JR47</accession>
    <name>A0A8J5JR47_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP-binding protein ypt4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ypt4-L</name>
        <name evidence="4" type="ORF">Hamer_G018271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027102">
        <property type="protein sequence ID" value="KAG7162747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JR47"/>
    <dbReference type="OrthoDB" id="28034at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001329">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7162747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="206" mass="23066" checksum="9ABC4CB7C8CB2AEC" modified="2022-05-25" version="1">MASVKVPEQKIILCGEYGVGKSSLFRRYATNTFVTATDRKSTLGLDHYEKVYRTGDKEVKLQLWDTGGMERVASITSSYYKFAEGAILVFALDNPDSFNILSQHLLDIVTYAESAKIFLCGNKYDLKSQIQVTDADMENFCEQCHNLISGIYKTSCKTGAGVEEMFADIARQLSDSNRSRKELETMNKDSFKVTPPEGEPEDSCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRR1</accession>
    <name>A0A8J5JRR1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein 8-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Mfsd8-L1</name>
        <name evidence="9" type="ORF">Hamer_G001822</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRR1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="68"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7160540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="620" mass="68344" checksum="15718C9AB7281033" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSD9</accession>
    <name>A0A8J5JSD9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSD9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="101" mass="10820" checksum="ACBF632E87E135D4" modified="2022-05-25" version="1">MTLFSNIILGHSLSVVDKSPAASIFDKVSQQFQDKHHGKCKAQPVNALANITLGDDDDGTTDDDIKVLGDLLVEELPQDFDAEVRGGSSNLPQNPSTSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSG2</accession>
    <name>A0A8J5JSG2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pigeon-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pigeon-L</name>
        <name evidence="2" type="ORF">Hamer_G004427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSG2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902004">
        <property type="term" value="P:positive regulation of amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028010">
        <property type="entry name" value="GSAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026172">
        <property type="entry name" value="GSAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630:SF1">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14959">
        <property type="entry name" value="GSAP-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-secretase-activating protein C-terminal" evidence="1">
        <location>
            <begin position="490"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="721" mass="80947" checksum="44483B085BC6B387" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JT11</accession>
    <name>A0A8J5JT11_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat and BTB/POZ domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ABTB1-L</name>
        <name evidence="5" type="ORF">Hamer_G011308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JT11"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18497">
        <property type="entry name" value="BACK_ABTB1_BPOZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18295">
        <property type="entry name" value="BTB1_POZ_ABTB1_BPOZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18296">
        <property type="entry name" value="BTB2_POZ_ABTB1_BPOZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="186"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="348"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7158649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="555" mass="63090" checksum="90E95B0E0B2ED8C3" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUI4</accession>
    <name>A0A8J5JUI4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glutamate receptor 1-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Gria1-L4</name>
        <name evidence="13" type="ORF">Hamer_G004941</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUI4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035183161" evidence="11">
        <location>
            <begin position="25"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="12">
        <location>
            <begin position="66"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7164567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="301" mass="33730" checksum="CD69FB3C1C94FAA0" modified="2022-05-25" version="1" fragment="single">VWCMILLALVVVFVAMVLTQLTQARLQRRLQEISLLGITKEQGTKGSRERKKAGERQDEAGRVGELVDDPSPWNPRGMSIRVVAGIWLLTALVISSIYRSNLKAMLILPKVSPPFTSLEELLKTSIPCYVLQGTVLHGEILTAEPGSHLYKLRKQMISHVDVPRAVKDLLQGKHAALIPLTSHLNIQHNNFLRTRTCSIYMKPADLSSFPHRYLFPKGSPLVHKLNPLLTRLKESGVLDYLYFSDIYHGIKCLKTTTTTTLLRPLELGDFYGVFSLYGGGMLIAGLTFILELIVGVHRHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV20</accession>
    <name>A0A8J5JV20_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Origin recognition complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Orc4-L1</name>
        <name evidence="10" type="ORF">Hamer_G014209</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the origin recognition complex (ORC) that binds origins of replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ORC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161639.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
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    </dbReference>
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        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4 7" id="KW-0235">DNA replication</keyword>
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            <end position="206"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR007858"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14629"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7161639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="426" mass="48623" checksum="606BA1C6CA8452A5" modified="2022-05-25" version="1">MGLKRQKSPVRSDPDLMKEVQKQLRLNLRLWGTTKEAGKRLKSLYSEEAQHLKDLMTRTLTLGESNSALLVNTVIEKLEASGTLGEGVVVRLSGLLQTDDRLALKEITCQLKLENATANKVFGSFAENLAFLLESLRCGSKETSKPVIFILDEFDLFCHHRNQTLLYNLFDVAQSAQAPICVLGLTCRLDVIELLEKRVKSRFSHRQIHLFPEDKFDPHYLNIFEQLLELPDSFPSKDFSRKWNSDVAVLLKDSEVIQVLKRLHNTTKDVRALKTLLLLCVSQLSSDQPQMTGHMFMRAQSLFASEAKTNMLQGISVLQLCLIIAMKHLTTIYEGEPFNFEMVFHEYRKFSRQRSTMQSFERPVVFKAFDQLKCLELVRSVDNNRGTQREYQLVQLMMTPLQVTEALGQLPGIPTDIQQWAASSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV51</accession>
    <name>A0A8J5JV51_HOMAM</name>
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        <submittedName>
            <fullName evidence="4">Outspread-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">osp-L</name>
        <name evidence="4" type="ORF">Hamer_G005045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="PH_domain"/>
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    <dbReference type="PANTHER" id="PTHR17271">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY PH DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN OUTSPREAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
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            <end position="639"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="692"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="820"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="1232"/>
        </location>
    </feature>
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            <end position="1507"/>
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    </feature>
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            <end position="2049"/>
        </location>
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            <end position="2491"/>
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    </feature>
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        </location>
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    </feature>
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        <location>
            <begin position="2715"/>
            <end position="2747"/>
        </location>
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        </location>
    </feature>
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        <location>
            <begin position="1263"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2050"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2202"/>
            <end position="2248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2274"/>
            <end position="2336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
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        <location>
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            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="306"/>
        </location>
    </feature>
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            <end position="328"/>
        </location>
    </feature>
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        <location>
            <begin position="360"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
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        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
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        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
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            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="842"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
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        <location>
            <begin position="1457"/>
            <end position="1474"/>
        </location>
    </feature>
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        <location>
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            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1991"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2014"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2031"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2428"/>
            <end position="2444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2462"/>
            <end position="2471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2476"/>
            <end position="2486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2633"/>
            <end position="2644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2645"/>
            <end position="2661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2715"/>
            <end position="2726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7164655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2848" mass="318493" checksum="9C13EBD854B6D8C1" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVC5</accession>
    <name>A0A8J5JVC5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G005224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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    </evidence>
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</entry>
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        <name type="scientific">Homarus americanus</name>
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            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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            <authorList>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWL6</accession>
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            <dbReference type="PubMed" id="34162536"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7165177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11780" checksum="2CF4DBA249BDA329" modified="2022-05-25" version="1" fragment="single">LNWLHELSWRTFIRGIQARECYPTLPIAAQSQSATARQTISVNKGCKYALGLETPTGGRGEGLEATSEAKVLVRVKDVNDHAQPSLGMCTRRRSQRRMIDTSPRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXV7</accession>
    <name>A0A8J5JXV7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glutamate receptor ionotropic, delta-2-like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Grid2-L8</name>
        <name evidence="15" type="ORF">Hamer_G002723</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXV7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="214"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7163529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="621" mass="68912" checksum="094919B2E7A66071" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JY83</accession>
    <name>A0A8J5JY83_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7166047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JY83"/>
    <dbReference type="OrthoDB" id="6380379at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="244" mass="27828" checksum="AF373DEF6E95EABA" modified="2022-05-25" version="1">MQWLETCLAVDCCVKTSYHLLHDRKKCHIFAEPPDTPVLQRLQRMTSTGLAKGTPLKGTDEKKEKESNKREKKSLKKVKSVKQGIAQRLGQKLCGRGEVCGTDAKSQHLIPRARLRASQHHPGHHTEAPHASSRCKVLPTCLPQIGDSLFYDLPRMRLDGGARAFRRRWGYELTPPPTLVEEENEDDPYTIPNDDDPDDNLSYTETRSLRDDYLYSSSQGKVGVRALCAVLLCFRNHRRRQRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0G9</accession>
    <name>A0A8J5K0G9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNase H-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G021761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021234">
        <property type="protein sequence ID" value="KAG7167880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0G9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="46"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="246" mass="27385" checksum="1E742BD38CAC7A1A" modified="2022-05-25" version="1">MTGERQHRGPALHRHLHYTDAKTDDHPIVQQQTSLQKITDVTTVIPEDSVIVYTDGSLQDTGAAGCAYVAYSGMTCVAEAMHRLPDWASTTRCELQGILGATNYVLDEERSGLVISDSRSGLESITSPRPVCQDLVRQIQHCLIREKTVALLIHFIWIPSNIGLHKRDYVDNLAKSACTLPIPDDASTITTGRVKTPLKKAALQTINEERSKQRGAGVSVRHYCKHCDTKYQYSRNKCLTRLSDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K224</accession>
    <name>A0A8J5K224_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Cysteine-rich, acidic integral membrane protein-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CRAM-L6</name>
        <name evidence="2" type="ORF">Hamer_G031291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022867">
        <property type="protein sequence ID" value="KAG7166083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K224"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="640" mass="74581" checksum="94338B4A174285B3" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2A1</accession>
    <name>A0A8J5K2A1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 784-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Znf784-L</name>
        <name evidence="9" type="ORF">Hamer_G007280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2A1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7165445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="118" mass="13088" checksum="8C7D9DE073C7255D" modified="2022-05-25" version="1">MAVFLHLQRAAFGAVGDFVPVGGQGDVASRRMGAAAPCPPVASAPMADLPTFIPNPEWRPYSCRFCFKKFKRKDHLTDHERLHTGERPYHCQHCGRGFAQKSNCRNHAIRCPAATNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2L9</accession>
    <name>A0A8J5K2L9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pro-resilin-like 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G011185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2L9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7166349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="360" mass="40365" checksum="F0CA07FB228AC9E4" modified="2022-05-25" version="1" fragment="single">MGATQQEKHKRRRYHRRKRLSTVVSSGYSSFTILLLLGVVAVATADRRPSYNYDSSQESEESDEYSAESTEAKYDFDWSVKDEDSGNDFGHQESRDGDNTKGSYSVQLPDGRLQTVTYYVDGDSGYVAEVKYEGEAQYPESDESDESDESDESYEYTAPRPRYSAPEPEEPVEAPIRVEDLHLVRTSSPQYETQTGLVAVAAADRRPSYSYSAPQESDEYSAESTEAKYDFDWSVKDEDSGNDFGHQESRDGDNTKGSYYVQLPDGRLQTVTYYVDGDSGYVAEILLLLGMVAVAAADKRPSYSYAAPQESEESDEYSAESTEAKYDFDWSVKDEDSGNDFGHQESRDGDNTKGSYSVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K310</accession>
    <name>A0A8J5K310_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G011983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7166045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K310"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="7796" checksum="F840AAAB97B846BE" modified="2022-05-25" version="1">MAPSLDQLVSRVPHAISSARGQSEIPRVAVWLCLWSTVCVCVSVDLDTPSIDLVFSNLIDSSRHCEKKTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4N9</accession>
    <name>A0A8J5K4N9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DDE superfamily endonuclease domain-containing protein 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G031233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017855">
        <property type="protein sequence ID" value="KAG7169227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4N9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="153"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7169227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="353" mass="39869" checksum="1AA74F0AD34EA33C" modified="2022-05-25" version="1">MPRRHRITSATDRERIIEAYRAEQDFLVVAAALGVQRTTAYSIVRVYQRENRVEAAHAGGRHKIIDNETLDLILVMLLEANPMMTLREIKEEVMDIFPTKPHFSEVTLSRYLEGELISLKMSRDSPAERNSPAVKEARHAYATWMLATGLQQQLVYIDETGFNLWTKRTYGRARRGERVHRAVGGQRGRNTTVIAAIAEHCGILYHEIHYGSGTKEVFSDFITSLAAIIGDARSILVLDNAPIHNGIAAVYPELNFKFLPPYSPCLNPIENCFSVFKSYLKQYLHREAPRCNAAHARQEGVTLNALRENILQVGVEFALPSVTEHVVSQNYITMSTPTWFNVLSAETSSIDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K515</accession>
    <name>A0A8J5K515_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G021697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013604">
        <property type="protein sequence ID" value="KAG7170762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K515"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="439" mass="49200" checksum="EE090B84AEAE5DE5" modified="2022-05-25" version="1" fragment="single">MAGKCTGPHTLCHQPLEQVSAVSTRPLLSFIPRVASKYSNARMSMWWWWLLILMWTTASSCSNLQQAQDCLIYQPGSRSPHNTKLHKSFNGVISIGFSMKNSQQSSAVLTISGGSGANCTINVYYYTKSTIIQKAPYYLYAIGVKCGDNEKTLIEEPLDSIVKNWMYISIRIKPDKTPEDSVSSHLLLSPNSNIIVPNFNRNSRLEIHSTIKKFYLNCRKGCYKSHKELTCSLGRSIFYVRITTDSDPGRLTVNTTYHYDYTQVISLPPDCLTPNTWQVVSLSGKRQSLTVRVDGQQILENPTNIYFPKVTGITISLEEGGLLTWCKPPHTDAIHTAAWKIATGLLTVFFTTSGIFWYLWHQRNQLRTSNPEPKGLHLKFFSESTPPPLPPPLIPPSINRPSPAQQSRVPSSPIFPPPRAITIPSQVIEPPPTYPSTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K7U6</accession>
    <name>A0A8J5K7U6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Dolk-L</name>
        <name evidence="11" type="ORF">Hamer_G013811</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010012455">
        <property type="protein sequence ID" value="KAG7171345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K7U6"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7171345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="507" mass="54710" checksum="75B30B30C6144AB4" modified="2022-05-25" version="1">MKITCTMPFSNAMMNIASKLPSVSPLHLDHLNTRYGASPGVWLMLLVPLACSSGLYTAYIHCYPPSRLLALLAIQVGVSGIHLYKQMCVSGSHHKTESQDNTQTSSLFLRFLFHPYTPALVTAVAISFLTEIHPIGAIMATTLCAWILYELTHWLFRSFPGSFSLGEGAVVGQTGALAITCSLCNIFTSILMPRMLSDSQKISLFVQTAVLIFSSMVVGLYKLPLLHTARMFVPFVCVCGTAGVAVSSLLLGKWTPLWLLDLIIEAPTRLTLLAWWSGLALVAVALTTWARRRSNIATTVLRKVYHVVIILVFTPGILLEPAFTHLAATAAVMFCLLLEMVRVKEIEPIASIISQAFSTFLDEKDGGTLVLSHIYLLAGVASPLWISPCQFLEVEVMSKLPPESVLPLLAGVLAVGVGDTAASVGGTYLGRRRWSGTKKTVEGSLCGVIAQMMAVLVLVGIGVVDVSLAAWGRLVISASLVAVVEALTDQVDNIVLPLLLYTPLMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K812</accession>
    <name>A0A8J5K812_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-beta-hydroxybutyrate dehydrogenase-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Bdh1-L3</name>
        <name evidence="1" type="ORF">Hamer_G002636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K812"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="103" mass="12133" checksum="30D9590C824CB0E7" modified="2022-05-25" version="1">MWGSMSEEVRADYGKDYFDTLVKFAKTQANSGEKDMTSVLHAMTEAVTKRYPRVRYHAFDCYYFFKQKAVIHLPEWLSDLLYITRPPLRQLSQQKTTAQTKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K984</accession>
    <name>A0A8J5K984_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">KICSTOR complex protein C12orf66-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Cl066-L</name>
        <name evidence="1" type="ORF">Hamer_G023714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019101">
        <property type="protein sequence ID" value="KAG7168760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K984"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061462">
        <property type="term" value="P:protein localization to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038060">
        <property type="entry name" value="C12orf66-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018544">
        <property type="entry name" value="KICS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31581">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN C12ORF66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31581:SF1">
        <property type="entry name" value="KICSTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09404">
        <property type="entry name" value="C12orf66_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160651">
        <property type="entry name" value="FLJ32549 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158548">
        <property type="entry name" value="FLJ32549 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="444" mass="50427" checksum="E8DA610132655D4D" modified="2022-05-25" version="1">MASSTKHSSDHEEVILQGLLAHFSNFNYDKAKEHAEKERDTSRFSGSTVWQSLLTCVTQLAATEKLYMNLSFLTAKGFLRKESSVRASYELLNVELGELGTEKKKTVSNNGNASTGGPTSSGSPGCDGILRHLCSHLVLFIKARLQMIVFYERLIEMSVCRLMNFEELLSHLIDVSAKNSRNFHHPLLTPIKTGFTYECDILIHLLRSQIEMQCWRFLPSLLHLHDAHSKLNSWHTLVQSKETKKYGFGSSFLKSSPLPALYQWFWQAKAAFVSKFSLYFHETLAAQSSPADMKALISRQGQACDYVSKSDAASVCLVFEAAGVEDYQGAGYHHPEESMPPPKGLDSYPAIFTYPPTKPMDRWPSIVMRVSDRSNEHDLLDRVVHFYDQQVGSTYFLCRVEPRITFVAVFDAKKSEKDNYIRDFVYDLVMQLRCNKVFANLKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KAB3</accession>
    <name>A0A8J5KAB3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Helicase SKI2W-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SKIV2L-L</name>
        <name evidence="12" type="ORF">Hamer_G021875</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014991">
        <property type="protein sequence ID" value="KAG7169871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KAB3"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000447">
        <property type="entry name" value="helicase SKI2W isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="291"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="527"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7169871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1212" mass="137541" checksum="3816988540759D7A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KBT3</accession>
    <name>A0A8J5KBT3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pol Retrovirus-related Pol polyprotein from transposon-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pol-L5</name>
        <name evidence="9" type="ORF">Hamer_G012400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KBT3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="422"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="437"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7170156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="473" mass="53023" checksum="2660247506A500AB" modified="2022-05-25" version="1">MQSRYATIELELLAVVWALSKCKFYLIGLQHFDLIADYRPLVPILNHYSLDAIKNPRLQRLKEKILAFVFTAAWRAGKKLCISDALSRSPVSSPTPEDEMLSTEAGFSVSNIVTLQAVQSLASTQASVSPPDSDLALEELRTVTRDDLSYIQLLESVRTGFPRDRFDLHNALRPYWKIREDLYADGDLVLYGARVVVPAALHRRVLARLHNTHRPSSPADFFSTAGKHFLVVADRLSGWPVVVICGSDTTSAATIRHFWHLFRDLAVPSNGHAEAAVKAVKHLILKVAPSGNIDCEAFDKGLLELRNTPTHSGRSPAQILYGHPLRSCVPAHAKAFAKEWQTRAESCDRRAATRAQDTKARNDDRARPLQPLEIGALVRVQDPTTTRWDKVGIVMGVGRSRDYKVRMPSGCVWWRNRRFLQPVPPPAASPLTEDESPTPHEDPSHSAPRRSERLRTKKSAQDKDYEREGGREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KFZ7</accession>
    <name>A0A8J5KFZ7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012319">
        <property type="protein sequence ID" value="KAG7171386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KFZ7"/>
    <dbReference type="OrthoDB" id="6360146at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035196170" evidence="1">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="246" mass="27848" checksum="F871C8EC3D0BB65F" modified="2022-05-25" version="1">MFGTAVLGVVMALAWTVTGLPDYGAPSGGGYIKVAPISPSYGPPPKEQACYPKYVTKTMTKDVQDTEGHYASVVKKVATTEYAYITETLVYPKTIIQYSTMTAYAEPNIYTETKILYDTKMVTVPVYMTESAYGYNTAKQYFTETTAVYVTRTETQSYPMTNTVTNTGYETKGYYVTQTKVQQQYVTMTVTNPYYVTQYETEVKHEYVYNTVTESVHQYVTMTVYNTVPEYHTVTKCSTMMYGYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KQD9</accession>
    <name>A0A8J5KQD9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AT-rich interactive domain-containing protein 4B-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Arid4b-L2</name>
        <name evidence="8" type="ORF">Hamer_G013715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012455">
        <property type="protein sequence ID" value="KAG7171264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KQD9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20390">
        <property type="entry name" value="Tudor_ARID4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012603">
        <property type="entry name" value="ARID4A/B_PWWP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08169">
        <property type="entry name" value="RBB1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="7">
        <location>
            <begin position="270"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7171264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="382" mass="43557" checksum="C9E5AAE0FA0B05D0" modified="2022-05-25" version="1" fragment="single">LYNESFYLQVTFKLGLGSTVVSDDQVKGVLKIGAQVKASHPDKNQYVDAIVNKIQDCSQYTVVFDDGDITTLRRTSLCLKSGRHFAESETLDQLPLTHPEHFGTPVGGARRGRRSRQHHEGDESGDDDDDVHKRHRSRREEWESDIGKVVCVELGDKKKQKDNWFPGLVVAPTSQDSVKIETKKDYLVRSFQDGRYYTVPKKEASPFSREVGSKVSQSALKIAVEKALLFMTNDELPPHWDRDLLFGMDVSDDDSDRDGSDSDSSDDEPREEKDHFVAQLYKFMEECGAPINSGPTVGNKDLDLYKLFKVVQKLGGFNRVMNQNQWKVVSNKMQLQSLGSQGPNHIKAAYKRWVSCFVSILYLQKIQHFMKVWGKRRMFKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MGR9</accession>
    <name>A0A8J5MGR9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 130-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G010641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MGR9"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7153336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="428" mass="48339" checksum="7DDA8C37AE4A52C3" modified="2022-05-25" version="1">MGERKGVNKYYPPDYDPSKGGLNKFQGTHALRERARKLHLGILIIRFEMPYNIWCEGCNNHIGTGVRYNAEKKKVGMYYSTPIYQFRMKCHLCDNHFEIKTDPANLDYEIVSGARRQERRWDPTENEQIVPEDKEVTRKMAVDAMYKLEHGVSDKIKPKETDTVLEQLEEFQASRWHDDYASNKALRATMRAKRVEAQARAARDALYHISVPLLPTNEDDARTAKLLQLTQSKTSDQVREEKRAIIDAQSVFAKLKTKKVPQTTKKAFARQSLKGIVSNSQKNLNNFKNNIPIGPLNLGIVPRKTSLQDSSEKLPDDSEGEKGTTNTQRRNLLCINNITLNSPDNSSSIPETTPSTSANLDIMTQTAEQCNFVSTNTEHVDNTLNSQICQKSPQVSENSTAASSSVKEKVQCLVSYDLSASDSDDSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5ML16</accession>
    <name>A0A8J5ML16_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chlorophyllase-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clh1-L</name>
        <name evidence="1" type="ORF">Hamer_G024548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041629">
        <property type="protein sequence ID" value="KAG7155453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5ML16"/>
    <dbReference type="OrthoDB" id="2093222at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017395">
        <property type="entry name" value="Chlorophyllase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33428:SF14">
        <property type="entry name" value="CARBOXYLESTERASE TYPE B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33428">
        <property type="entry name" value="CHLOROPHYLLASE-2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07224">
        <property type="entry name" value="Chlorophyllase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7155453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="377" mass="41457" checksum="813073B243ED798A" modified="2022-05-25" version="1">MSVGQADEKDNVAQPILHHLHLYTMILESVLVPLLFVTVCRCGAQEDFKPYERGSHNTASVHIQSLYTLGLQENLDVWLPTDAGTYKVYYFLDGFDGVIPGVAYAQTMDHIASHGVAVVVPWKITASIDPDVRMSLFVSVMNWAENHLEKKLHNSGINDTVHLDLDNLVVGGHSAGAHVQVEYLKSTCGKFKGQVFMSPVDGLTVFCITPGQTLNYIIPTLHLAAGLDNVPGVGGFPCAPDSLSNDRFYDALDPTSQRWSVNATQFGHGGFLDPLYEESLEVLDFCGYNVNATDDEFDAYRRYIAGQIVTFIKALFTEEGDCGQYLPYLEDTSRMIVDTEERHQNPVGGCPVAACTWSPLPNTTAVPPTTTLDVQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLG3</accession>
    <name>A0A8J5MLG3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Teneurin-m-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Ten-m-L2</name>
        <name evidence="13" type="ORF">Hamer_G015932</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tenascin family. Teneurin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041065">
        <property type="protein sequence ID" value="KAG7155572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008038">
        <property type="term" value="P:neuron recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.180.10.10:FF:000008">
        <property type="entry name" value="Odz, odd Oz/ten-m homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000021">
        <property type="entry name" value="Teneurin transmembrane protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000013">
        <property type="entry name" value="Teneurin transmembrane protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.180.10.10">
        <property type="entry name" value="RHS repeat-associated core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057627">
        <property type="entry name" value="FN-plug_TEN1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056823">
        <property type="entry name" value="TEN-like_YD-shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056822">
        <property type="entry name" value="TEN_NHL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056820">
        <property type="entry name" value="TEN_TTR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028916">
        <property type="entry name" value="Tox-GHH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF72">
        <property type="entry name" value="TENEURIN-M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24329">
        <property type="entry name" value="FN-plug_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25021">
        <property type="entry name" value="TEN_NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25023">
        <property type="entry name" value="TEN_YD-shell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15636">
        <property type="entry name" value="Tox-GHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25020">
        <property type="entry name" value="TTR_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7155572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2184" mass="243385" checksum="2BF92B5F47ACD609" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLL0</accession>
    <name>A0A8J5MLL0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLL0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035217879" evidence="1">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="79" mass="8931" checksum="B3DB37122BD71188" modified="2022-05-25" version="1">MKCSALVCCLLVLSLNVTAQALPNGVRSESDASRVVDASPYNILGLSISCRRCYIFNRHLNTCVPNMRCMFRDRRRGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLU1</accession>
    <name>A0A8J5MLU1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039935">
        <property type="protein sequence ID" value="KAG7156141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLU1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="223" mass="24633" checksum="44794697542AD5ED" modified="2022-05-25" version="1" fragment="single">VEVGPPLPALSEGVIKDLSTDQSYAYRIAQAIRSGEVPQSLTLLEIGPLVRTQRKVVRDIVLPVARRSAWYARSEAVLQAMLCNQCTNLRTEAVEVILKIRGTLIDDDQLGDCSFHSRKVPPINVNATKLSELVDLSLEVLEPPLTTNLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERQEEEGGGVEEKGEGGKGKEEGKGERGWDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMB7</accession>
    <name>A0A8J5MMB7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">High affinity cationic amino acid transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Slc7a1-L</name>
        <name evidence="10" type="ORF">Hamer_G006499</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097638">
        <property type="term" value="P:L-arginine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF105">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="686"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="854"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="885"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="915"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="948"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="HTH psq-type" evidence="8">
        <location>
            <begin position="235"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="9">
        <location>
            <begin position="917"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1006"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1067"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1158"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1211"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1075"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1087"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1098"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1158"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1179"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1237"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7156530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1457" mass="160976" checksum="823447ECAFD2C9FF" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MMP5</accession>
    <name>A0A8J5MMP5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endoplasmic reticulum resident protein 29-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Erp29-L</name>
        <name evidence="5" type="ORF">Hamer_G023776</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038733">
        <property type="protein sequence ID" value="KAG7156802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MMP5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1150.12:FF:000001">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016855">
        <property type="entry name" value="ERp29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012883">
        <property type="entry name" value="ERp29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12211">
        <property type="entry name" value="ENDOPLASMIC RETICULUM PROTEIN ERP29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12211:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07912">
        <property type="entry name" value="ERp29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035309167" evidence="2">
        <location>
            <begin position="17"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ERp29 N-terminal" evidence="4">
        <location>
            <begin position="40"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum resident protein 29 C-terminal" evidence="3">
        <location>
            <begin position="153"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7156802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="253" mass="28963" checksum="C151CB23C7B5C5BD" modified="2022-05-25" version="1">MSLVLLLFVLSKGFKGSRVRDVRVRGFGTGGVDTWQTTPSVGWSRIVPKFHAAIVKFDIAYPYGKKHEEYTKLSAAGRGSPELLVAEVGVKDYGDMENMDLAERFGVTKEDFPKVKFFVNGKDKPFDFDGEFNAEELKKFIRRHSEVYIGLEGCLETFDRIVDRFMTTENQSDKKGLLRKAEDEWDKLKSPSDQQIAETYVKIMRKVLEKGGEFISLEKTRVEGLMIGRITKEKKEEMQGRLNVLKSFTHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNK4</accession>
    <name>A0A8J5MNK4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035811">
        <property type="protein sequence ID" value="KAG7158061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNK4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="251" mass="28854" checksum="8DE4720D153F94E0" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIEPKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSEFVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MP72</accession>
    <name>A0A8J5MP72_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G021114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034714">
        <property type="protein sequence ID" value="KAG7158540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MP72"/>
    <dbReference type="OrthoDB" id="6371836at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="240" mass="26961" checksum="71748D051BBB51A7" modified="2022-05-25" version="1">MPRSLSSGMVQEGGRLSRPPENPTPHKTPETPDTPLNEEELTPVPMAGNDEEPDVYIDTNTGKKMTNVTPCCGCRTCDARFPLEMDEETSYVYREAKYCKLSYTFISSWCLMLFVATAASSGIIAIGFLDKELIKYQVVGIVLTIIFGAALPVFLVFWVCLRRREAVVRRRYRAQKNSEQVLEREGALPPDDKKKNKEKKDENGKCKTKKDKLEEDDKEDTKIETPPTPGSSGDTQLLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPA6</accession>
    <name>A0A8J5MPA6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Broad-complex core protein-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">br-L3</name>
        <name evidence="6" type="ORF">Hamer_G011493</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPA6"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000448">
        <property type="entry name" value="RE1-silencing transcription factor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF93">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 14-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="53"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7158811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="516" mass="57998" checksum="C7BCE41E77121A12" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPG3</accession>
    <name>A0A8J5MPG3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase-like protein 7A-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Mettl7A-L4</name>
        <name evidence="3" type="ORF">Hamer_G027812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034333">
        <property type="protein sequence ID" value="KAG7158840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPG3"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="106"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="283" mass="32522" checksum="A472474DFEBEC0A6" modified="2022-05-25" version="1">MSGENAYHINLVEENADQDGSDEGDLTLMPWCYHNLFTIISIVAVLWVIHRLVLGTQPKWFAYMMYLYTKYEFVQFEEVKKDHFASLSSVVSHDPELRKKKEIRILEIGVGTGVNFAHYPEGTHLVGVDRNLHFKSYWEENRKQFPNIYSGEMLTTSAENIEAVADNSVDVVVITLVLCSVPKIDPILKEVLRVLAPGGKFYFMEHIAEFDPEKHGLRKMMQDVLTYLYVWPFIYDGCCLNRDMLPNIKKAGFSSVEAEKYYAPVPNIIFDVERPNLKGIATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MPG6</accession>
    <name>A0A8J5MPG6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Tigger transposable element-derived protein 1-like 282</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TIGD1-L282</name>
        <name evidence="2" type="ORF">Hamer_G006387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MPG6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="84" mass="9543" checksum="3063E58BB59EBA54" modified="2022-05-25" version="1">MDMRSPPVPPTTPASSSKRDHQEYSNRPLWPECVLQRDFEGFEESEEEAVVHEIVALGNSMGLEVDDDDVEELVEEHSKELSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQH7</accession>
    <name>A0A8J5MQH7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7160026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQH7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="17" mass="1973" checksum="3F9DBF482E5EEBE9" modified="2022-05-25" version="1">MTVFPPAWWLLGEGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQP9</accession>
    <name>A0A8J5MQP9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U-scoloptoxin(01)-Cw1a-like 52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G029380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032024">
        <property type="protein sequence ID" value="KAG7159832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQP9"/>
    <dbReference type="OrthoDB" id="6364363at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035250941" evidence="1">
        <location>
            <begin position="20"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="235"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7159832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="594" mass="57265" checksum="52FE7FE6998C1521" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQU6</accession>
    <name>A0A8J5MQU6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly protein COX11, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Cox11-L</name>
        <name evidence="9" type="ORF">Hamer_G017356</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with CNNM4/ACDP4. Interacts with RANBP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7159922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQU6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7159922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="310" mass="36771" checksum="7C7082D0A5646FE1" modified="2022-05-25" version="1" fragment="single">ELRHQEQELRHHEQELRHHEQELRHHEQELRHHEQELREQELRHHEQELRHHEQELRHHEQELRHHEQELRHHEQELRQQEQNLRDKQPGRNVSTFNLVNKFLSGKPVNIVPLMRHLSIGVQRQQKSEEKEPSGGTKASFISRGTRSTLYYIAAVWAYSYGGTPQEGHDAEKVESMQTVESRKIRVRFNADTAASMTWNFKPQQSEIKVHPGETALAFYTAKNPTNRPVIGVSTYNVVPFDAGQYFNKIQCFCFEEQLLNPHEEVHMPVFFYIDPEFADDPKMQNVDILTLSYTFFEAREGLQLPMPKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRR6</accession>
    <name>A0A8J5MRR6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Speckle-type POZ protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spop-L</name>
        <name evidence="3" type="ORF">Hamer_G014164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRR6"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="166"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="522" mass="57483" checksum="7AD8D0A1EBC4FBE2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTN9</accession>
    <name>A0A8J5MTN9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G002176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTN9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="588" mass="65141" checksum="164F9E6777797993" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU75</accession>
    <name>A0A8J5MU75_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="12 13">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Mogs-L</name>
        <name evidence="16" type="ORF">Hamer_G002235</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="12 13"/>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU75"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000009">
        <property type="entry name" value="mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="15">
        <location>
            <begin position="194"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="14">
        <location>
            <begin position="434"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7163159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="913" mass="104181" checksum="72D83BBC32EBBC16" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUK4</accession>
    <name>A0A8J5MUK4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Polq-L1</name>
        <name evidence="8" type="ORF">Hamer_G004988</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097681">
        <property type="term" value="P:double-strand break repair via alternative nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000002">
        <property type="entry name" value="DNA polymerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.10">
        <property type="entry name" value="Taq DNA Polymerase, Chain T, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="DNA POLYMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133:SF62">
        <property type="entry name" value="DNA POLYMERASE THETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="7">
        <location>
            <begin position="1125"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1273"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7164603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1411" mass="156695" checksum="2D8A47EAC1061698" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MWE3</accession>
    <name>A0A8J5MWE3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MWE3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035320761" evidence="1">
        <location>
            <begin position="22"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="259" mass="28452" checksum="8527C3B6E93D92F4" modified="2022-05-25" version="1">MAGTVMKVMALMLSNFLVTSAVITTIKVYKVASSHNDPFPICTIKVVEMQRISRTSCALKCLEEPLCRAFCVKGASCHINGGHLDGRWPGAAVGHIYPGIFTYDYCYAYLEEGDVTSHIVSTSASTVHSEGLYPEFVINGFYCHIPKYHGPLFYCWAASPSDVQGYWRATLDSPQTISTIYVWTRGDGHPTPTFDNVEITFGTSSDFDNPVFDTYPNTALITGEMITFTATSPVTGQYLQVRDLSPTGPLGICNIQLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MX54</accession>
    <name>A0A8J5MX54_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MX54"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="115" mass="12964" checksum="CB52782B4ADCF291" modified="2022-05-25" version="1">MKSVVLVIQDCQPYPLHIYKLLWYCGNCTIFPHSSSITDQRTTSTTKPEIRGADNYPPPEMKLRPLGKALSLNVLSQSSRGLWSHPQGNLHLTEEVEAEVAVWRGEEDVPVTMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXH3</accession>
    <name>A0A8J5MXH3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcineurin subunit B type 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CanB-L</name>
        <name evidence="5" type="ORF">Hamer_G013017</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXH3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7167543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="127" mass="14467" checksum="E7B30BF610179211" modified="2022-05-25" version="1" fragment="single">MSLPELQQNPLVQRVIDIFDADGNGEVDFKEFIQGMSQFSVKGDKESKMRFAFRIYDMDNDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTILFADKDEDGKISFDEFCAVVGNTDVHKKMVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXS5</accession>
    <name>A0A8J5MXS5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021712">
        <property type="protein sequence ID" value="KAG7167332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXS5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="263" mass="29083" checksum="87E43930D6D405EF" modified="2022-05-25" version="1" fragment="single">SMESTRSKTEVWLIGQHITEITGVQLPSRGDVLRLFFHGHNEHKKTVNDSASEVAASVISFWNKARIPTITEKSIGRKVVDLFLMWKGLKKNCTRTTDTQRKKEETFCDELEDLFDVAHPKAMQLLTIKEDRAFLAAQREKGRRGVMAGVDKKIACSIKRREESKSKQSLQQNQASSALEYDELGSSSETESQSSSSSSTSSLAISPVVSSSNRKRATLKVITPELSSTLDRTGISHRSALRIVSATAASLEPPMNTMLSAHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY91</accession>
    <name>A0A8J5MY91_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY91"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="98" mass="10747" checksum="FEB68AB813A62241" modified="2022-05-25" version="1" fragment="single">TWVGVVLTLVLVTIVHLVFIKVKELPDGGLSHTLLEVVRTILRLDASDLSCDYSVRPIMTDYGSYIPSALASSLDPALRKLGQSLEVIPYNYDLGLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZP7</accession>
    <name>A0A8J5MZP7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RUS1 family-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Rus1-L</name>
        <name evidence="9" type="ORF">Hamer_G012358</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZP7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055412">
        <property type="entry name" value="UVB_sens_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24160">
        <property type="entry name" value="UVB_sens_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="82"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Root UVB sensitive protein C-terminal" evidence="8">
        <location>
            <begin position="311"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7170120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="357" mass="40160" checksum="3DEF048146DA0EE7" modified="2022-05-25" version="1">MKTNDGALLYQERKGSTACQKTYVYQKSAKTFIPVTVDEKGRNTVSIKDHIGEWLKDVFLPRGYPESVSPDYLQYQMWDTIQLDCNSKQWRLFADVANDLGHLLKLLGPLLPVPFLAVMCVSAVMMALVGVAGGGTRAALTSHQARRDNMADVSAKDGSQETVVNLIALFTSLTILPIITSSFMLTWMTFVLCVVFHLLANYWAVRAVKMESLNRPRLLYVLHHWFTGAAVPGIEETNLSEPLLFGAAFIPNYFPYGFRTMLGCSFHWALECCRSNEDVMTLYSSTMDTFTQENYLGSQLSAEYVAEGLSTTAPDMEVLTIVKRHAQKIFPTFLQNLQEKGWLPDKLHMAAAEWRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0G2</accession>
    <name>A0A8J5N0G2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Tyrosine-protein kinase RYK-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Ryk-L</name>
        <name evidence="14" type="ORF">Hamer_G023418</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013714">
        <property type="protein sequence ID" value="KAG7170750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0G2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2170">
        <property type="entry name" value="Wnt, WIF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003306">
        <property type="entry name" value="WIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038677">
        <property type="entry name" value="WIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02019">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00469">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50814">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="WIF" evidence="13">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="267"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7170750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="521" mass="57636" checksum="71DD403EB72A94F3" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1L6</accession>
    <name>A0A8J5N1L6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1L6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="495" mass="56142" checksum="80D02B0D3376BABF" modified="2022-05-25" version="1" fragment="single">MRRENVHEEHGQSCDNHWRGEFINGGEVQFQFHTKVERNQMYARVLLQVVHVAEEECYRDQESSHMKTADPANTPEAPAIAGSTMSNSILPTRCSEYQLASPARAQETASIPNGRGGERLDHERREQLQHQRRGDNDRIAPPPFHLKITQWNVQGLSNKRHTVQVAAIAKNIDVFILHETLMSKDKQFRLPGYQQATIPSSEVEPVHCGEGVEAQAVRIHLANDSLVVYNIYKPPPKRLEAGELLTQATQELWCATFNAHTSLSELWRKLRIATRKLPRAPAHPQPLQEANRFAEHFAERSSSAQLPPEIRLHLQQVQLEREVVRVNMMRAMTGPKVGTGHVVLRTLYIHAIRSLTDYATPALNTLFEWQWEKLEVTQNNATSHCQGTYVDKNLKLTHGDRAELLTACFATKLITRAQESDIKNGLLRAMNLNRDVFNKKTWLLSAADAVNLLKLKDTMLSKEPDTMRPAYSTPAPWESPPAVFNILQTGTRKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1S2</accession>
    <name>A0A8J5N1S2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1S2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="653" mass="74828" checksum="EEB940236AA45CD1" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N204</accession>
    <name>A0A8J5N204_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Microsomal signal peptidase 12 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Spase12-L</name>
        <name evidence="12" type="ORF">Hamer_G023933</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011789">
        <property type="protein sequence ID" value="KAG7171726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N204"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7171726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="101" mass="11256" checksum="71FC7CCC19F84B80" modified="2022-05-25" version="1">MMDTVLGFSVHMDFEGQKLAERLFQIIVVTFGAVGWLYGYYVQDFFMTVLTLGAGFVLACLVTLPPWPVYRRYPLKWAPPQDAASASTSGAENTSGKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N237</accession>
    <name>A0A8J5N237_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Arpc3-L</name>
        <name evidence="6" type="ORF">Hamer_G000834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARPC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N237"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7171898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="74" mass="8302" checksum="7C0D3C2BCBA4187C" modified="2022-05-25" version="1">MPAYHCNLPHPGSVVGNMAMLPIRTKYRGPAPVMSAEGIDVVDEALQYFKANVFFRTYEVKSPSSLFLEIHHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N429</accession>
    <name>A0A8J5N429_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Velvet complex subunit B-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">velB-L1</name>
        <name evidence="3" type="ORF">Hamer_G008559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N429"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035264425" evidence="2">
        <location>
            <begin position="21"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7173038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="262" mass="28841" checksum="A7559B9D1C752A46" modified="2022-05-25" version="1">MSRIVLALALVALVRGDAEADPDYPAARPPTSYGAPPAPSYGAPPAPSYGPPPAPSYGPPPAPSYGPPPAPSYGPPPKPKNTCPKKCYEKTVYTTITNTAKEHHTSWNTKNQYEFVTQPLPDQVIYETKVAYNTDRIEEAHITTVQEMMPGTHYYMKTLTESNYCTNTVQVSSLLRNGDGTRVQDSPGTPLRHGDQVEHNYVTVTEDEPHYVTKTDLKTEQQHMYVTVTETKHGYHTITQTKTEPHYTTVCNYGSGGYCSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4D8</accession>
    <name>A0A8J5N4D8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Sentrin-specific protease 1-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Senp1-L3</name>
        <name evidence="2" type="ORF">Hamer_G014556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010116">
        <property type="protein sequence ID" value="KAG7173233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4D8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="500" mass="55655" checksum="25A73C4DE19F99C8" modified="2022-05-25" version="1" fragment="single">MLSAVTSRFKHFLWGNSHVKETRKRSLEEESEEEESSGFGEGEPAPKKSRLLTVNHDPPINRSYSQIGSKFCVGITKVYSFISGLSSPLFSSKDMTDSPDSSGQSLRVNVGGSRKSSRGKGLAESTTTAGEHFTRDKDPGPSGLDLTSSLMTNDDDIQFLGASSRTGYTDAPTKRPALGRRATAPEHSQPPVPSINPNFRFSPTVSPIAPQAPPDLTLRPSSKEPSWFKNSLAGRKVSYLNKKPGSLGRNPIKSLNEKCYGIQKKKQIRSTFLFHRGNSCAEESFRYEDKANYQQLLQQYTESSVLPSSSSNSTSPIACITRSRFNSFWTDEKRRQLEDTLSASRLSSTLAVDATASSDLATEKKSSTSDILLVDLVRAESTDSETDSVIFVKELTKPVSRSNSLESIIQESPVYNTDWLKSLREKYGNRSRAASDEAELAAEMQKRFEERRAKCHSSLEDRITHRMKFLDLTFPSKVEEIQPEEEEEEEEELVPLTSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5C1</accession>
    <name>A0A8J5N5C1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009070">
        <property type="protein sequence ID" value="KAG7173721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5C1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="152" mass="17414" checksum="A80599E95C5EBE1A" modified="2022-05-25" version="1">MAVDRIVEAWRKIDVETVLHLWKSLFANSEQLTNEEMLEEDEEQEEHQATQEDDVKPGKPTTRQLTELLTTIARLGEPYVLCPDKGMEEYKALYLSRVNARQQALITRYLHKAQLVINALANITLGDDDDGTTDDDIEVLSDLLVEELPEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5Q9</accession>
    <name>A0A8J5N5Q9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heterogeneous nuclear ribonucleoprotein K-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Hnrnpk-L1</name>
        <name evidence="5" type="ORF">Hamer_G021547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008528">
        <property type="protein sequence ID" value="KAG7173930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5Q9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7173930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="142" mass="15290" checksum="4AE3A9118703D169" modified="2022-05-25" version="1" fragment="single">MKRMSEMEGETPLKRPRPAGDTELRLLIQSKAAGSVIGKGGQNISRLRSEVCMARRCGRAASGGCRRGEGGDQHPRGRHECQARVLTIGGSEDVVLKVLNEVLECLDEALQKGTESDARILVHQSQAGCVIGKAGSKIKELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N646</accession>
    <name>A0A8J5N646_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G017999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009070">
        <property type="protein sequence ID" value="KAG7173710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N646"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035305010" evidence="2">
        <location>
            <begin position="26"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7173710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="282" mass="31605" checksum="BF8D77FD623B040F" modified="2022-05-25" version="1">MQQRMVWARHIFVWLMIVMPLPTNMQDCLSGQLSLQNDLTPSMMLEEAVMLQLRPRTIVEKLSIQLLLETAQEGLLYCLGMDVNMNAQWSTVVTMKDASTNTTIFKVPWPVTPIPLTWTTLHLRLHYQHLLQFAVIPHKNTNIPRKFVSYHKNLNPLAASVHLLRTGVTRLRLKLLTVNTSIEYTINCEQESTETYFASEFGISSSVTGLHATAGSNSRDAAAPVLVSSRRGGRQPAPESTANSLHPHQVTVGVLSSRAPSPGHEIGEENTFDYINHAFTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N718</accession>
    <name>A0A8J5N718_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N718"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="84" mass="9626" checksum="A0195D4B6ADE3183" modified="2022-05-25" version="1" fragment="single">METGLIFLQNRTERLTACFVTKLITSAREVTSRMDSSDVFNKKTWLLCAVDAVNRLKLKDTILSKGRDTMSPDYNTPAPWETRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N756</accession>
    <name>A0A8J5N756_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Usp10-L1</name>
        <name evidence="10" type="ORF">Hamer_G003311</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family. USP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030330">
        <property type="term" value="P:DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000092">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="1109"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="166"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="569"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1245"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="605"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="652"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="734"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="789"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1254"/>
            <end position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7174372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1507" mass="163290" checksum="2FFF3300646EB05F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8G7</accession>
    <name>A0A8J5N8G7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Sem1-L</name>
        <name evidence="3" type="ORF">Hamer_G009844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8G7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13768">
        <property type="entry name" value="DSS1_Sem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="8263" checksum="76AC5563DE4657A4" modified="2022-05-25" version="1">MSTEKQGDTKPKIDLGLLEEDDEFEEFPAEDWGAAEEDAEDVNVWEDNWDDDNIEDDFSQQLRAELNIQPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N9T4</accession>
    <name>A0A8J5N9T4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005661">
        <property type="protein sequence ID" value="KAG7175543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N9T4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="100" mass="11462" checksum="544BADBA33D8C753" modified="2022-05-25" version="1" fragment="single">TYVIAKVGGVKDNGKRENNSHIVCGCPHEKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAS5</accession>
    <name>A0A8J5NAS5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pro-resilin-like 103</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G017035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004419">
        <property type="protein sequence ID" value="KAG7176064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAS5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035161124" evidence="4">
        <location>
            <begin position="17"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7176064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="213" mass="23791" checksum="DB0F9E159C2F1882" modified="2022-05-25" version="1">MKTVALVLSVAVVAWAAPQDSYNYQAPAVQQPQYPDAPALYNFQWDINDDYSGNFYGHQEQRDGDNTQGSYYVQLPDSRLMRVEYYVDETGYHPTVTFEGEAQFPSGPSRGYSQPAPAPSQTYSRPAPAPQQTYYVQLPDSRLMRVEYYVDETGYHPTVTFEGEAQFPSAPSRGYSQPAPAPSQTYSRPAPAPQQTYQQPAPAPSQFYSTPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NB31</accession>
    <name>A0A8J5NB31_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NB31"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="130" mass="14343" checksum="4D70275CF2C9E32E" modified="2022-05-25" version="1">MAACIIPLHVLIDCDHSSGFCGTGKKLVADRVQSYKEACDLLASCDSELQTPKDVLDDSEKFVIRYIYCDAKNTNMGEVSGVAQKNTILLAPVSDSLHLHFKADKLSQFSAEAPKLLIPPLIRRTWMAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NC35</accession>
    <name>A0A8J5NC35_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">40S ribosomal protein S10b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RpS10b-L</name>
        <name evidence="8" type="ORF">Hamer_G003759</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NC35"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7178011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="160" mass="18242" checksum="D6A5E213334E573F" modified="2022-05-25" version="1">MEPDSNNPLYPVQYCEVNLFITEGVMVAERDLFMPKHPELEKIPNLHVIKALQSLKSRGYVEQNFAWRHYYWRLTNEGIQYLRDYLHLPAEIVPATLKKPTRPEGRPRPLHSRPEGPRGEGSRDAYRRAPSGIDKTGDAGAGSAPMEFRGGFGRGTKRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDM4</accession>
    <name>A0A8J5NDM4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G025647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002520">
        <property type="protein sequence ID" value="KAG7177343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDM4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="145" mass="16233" checksum="2CE7C86FFED05DA5" modified="2022-05-25" version="1" fragment="single">CLMSLYNRAKVINSLKSAEDQENNLHSYIAFAELINIVEEELASDKINLELKDKLLAHIPARQAHVKGRCNLLVHDTTVGKILSDTFDETTERDAICLAKAAHRDMFDHLPCFEGSFSSDCQDKSVPPVLSCFFAHACSYISPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NGT1</accession>
    <name>A0A8J5NGT1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hsp70-Hsp90 organizing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HOP1-L</name>
        <name evidence="6" type="ORF">Hamer_G021890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000907">
        <property type="protein sequence ID" value="KAG7177941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NGT1"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF532">
        <property type="entry name" value="HEAT SHOCK PROTEIN STI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7177941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="251" mass="28296" checksum="D9AEC22A91D6668E" modified="2022-05-25" version="1">MSTSTEKVTELRERGNECVRAGNYAEAIIHYSHAIKIDSSSPQLYSNRSYAFLKLQQYYHALEDANEAIQLDPKWAKGYFRRGEVEFATSHFAEALESYRRASQLQNDPTLLECVLRANREMTRQQKVDQQTPWVGAGIGLILGVLVVVGDAIIAKESILTHPVLQSMVTIMLSLLGLGLGYCYRMYIQNQRKSLLEPPLDFLGVEDGDTRNGVSGGREKTSEGGGEGEERRHHPRYNKAQARQRYKKGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T3E6</accession>
    <name>A0A8J5T3E6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G009509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T3E6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="137" mass="14928" checksum="8852E688C1D6E4AA" modified="2022-05-25" version="1">MRKHSHQMGQVKSRRIVSRQVTDGVGPIFFITHAESAVLFIMAGVKKARIFPPNRGVPATMAGVGKSVAVRLPPSPAPQCRLSQLFSLDVTLPPSLSPSAPLLACSLTPPWPPHKDVSSRSSHMPFSSSRRSYLLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TBP2</accession>
    <name>A0A8J5TBP2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein bS16m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mRpS16-L</name>
        <name evidence="8" type="ORF">Hamer_G018907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009009">
        <property type="protein sequence ID" value="KAG7173761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TBP2"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1320.10:FF:000004">
        <property type="entry name" value="28S ribosomal protein S16, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7173761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="124" mass="13812" checksum="D9A737C30F36B73B" modified="2022-05-25" version="1">MLFPASGGARFGLRSTKCIRFAKHGCTNRPFFHIVVMEKRKPRQGHVIEQLGTYDPLANAFGEKLCSINLERTSHWIGQGALISNSCAVLLGLSGLLPLHPTSYMLAWRNRKAAEEKSQKEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TGC1</accession>
    <name>A0A8J5TGC1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">52 kDa repressor of the inhibitor of the protein kinase-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Thap12-L1</name>
        <name evidence="1" type="ORF">Hamer_G000958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TGC1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7171993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="73" mass="8311" checksum="18EA0312EF51B1DB" modified="2022-05-25" version="1">MKEYLEKCPKNAPYRSKTIQNELINICGQVIQKEIVDEIREGGGIFAVLADEAVDESNTKQLPLALRFVDMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJX8</accession>
    <name>A0A8J5TJX8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative zinc finger protein 56-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Znf56-L2</name>
        <name evidence="1" type="ORF">Hamer_G009944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJX8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="110" mass="12646" checksum="3A1B97F0BAEC0758" modified="2022-05-25" version="1">MVRTLGVQQVTNGKTGLLIRSKKISSAKNQKRLNHIEGITNWEKTREKKLDESTYLEEGVEEEVVTEEVAMDDLRTYVFQPPPEHNSLPKVNIRSSWNTINIDLKSLESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TKS7</accession>
    <name>A0A8J5TKS7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoporin Nup37-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Nup37-L</name>
        <name evidence="1" type="ORF">Hamer_G009209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003582">
        <property type="protein sequence ID" value="KAG7176400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TKS7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037626">
        <property type="entry name" value="NUP37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806:SF0">
        <property type="entry name" value="NUCLEOPORIN NUP37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806">
        <property type="entry name" value="NUCLEOPORIN NUP37 P37 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="179" mass="19437" checksum="50C74A4D69EF7002" modified="2022-05-25" version="1">MTSPRVCGRVPHRHRLRFLLTSPGMVVCFHPQDPDLLLVAEKKGVLRVYSVTSGCSTLFLRCPGPLLCADWSIPDPALIVAAGAKGLTVWNVASLQPHSEAVEVGGVERILALKVCRSTPGLVATQAAPHTVRVTHLHSNKIPIAVHLKVIGGMSWHQNLPYLAVGSDRKILLWKIDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLK2</accession>
    <name>A0A8J5TLK2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette sub-family C member Sur-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Sur-L</name>
        <name evidence="10" type="ORF">Hamer_G024605</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001842">
        <property type="protein sequence ID" value="KAG7177781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLK2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF461">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER SUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7177781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="223" mass="24704" checksum="B7013F6E74558020" modified="2022-05-25" version="1" fragment="single">MTFFMHCHYIWAIPLKVSVIMVLLWVQLGISAVIAAVVGILVLTPLQCLLCKKIGAVNKNFLDVSDDRLRQTHELVTGVKLVKVHAWEDVFIKRITAVRHKELKLLQHDSILRALMKSAALEPARVFSGLALFNQLTVPLFILPIIVSHTITAMNSTRRLQKFFSSPEVEGPKTPKTPITLRIPRGGGGGGGQTSLGAKLNLKENKLLDDNKTVRLSQVTEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLL6</accession>
    <name>A0A8J5TLL6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G027855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000087">
        <property type="protein sequence ID" value="KAG7178304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLL6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="261" mass="29964" checksum="06B371F38746951D" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKATALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIGRLFVSFKKSSPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLQ6</accession>
    <name>A0A8J5TLQ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA exonuclease 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">REX3-L</name>
        <name evidence="10" type="ORF">Hamer_G015202</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7174993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLQ6"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease" evidence="9">
        <location>
            <begin position="464"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7174993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="640" mass="69953" checksum="83D466966CD23A6D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TN85</accession>
    <name>A0A8J5TN85_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L antigen family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LAGE3-L</name>
        <name evidence="10" type="ORF">Hamer_G009767</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TN85"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7175758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="119" mass="13086" checksum="8EF4BD6EDD1BF5F6" modified="2022-05-25" version="1">MGDNSVDGAGNMESDEEISETEETLSTRQPAVATLEVPFNTSREAEVVRNSLQVDPEPKRSGSSKTFTLKENVLCVEIRSPDVRQLRTAVCSFMDLLHLVAKTVDQFGPPAQQSKKMCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J890</accession>
    <name>A0A8J5J890_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G027060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045660">
        <property type="protein sequence ID" value="KAG7154066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J890"/>
    <dbReference type="OrthoDB" id="6401706at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035206320" evidence="2">
        <location>
            <begin position="23"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7154066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="301" mass="33145" checksum="83A10C28FABD1E65" modified="2022-05-25" version="1">MKLVLLLVVFNVTTHNFGFTQATLDPSYITPISDPSHTTSTSDPSHTSSTSDPSDSKLTVPLDLASFDTERHTLGSRDSSGIRKSKSSPGLNGSKSPPDQEGSKSPASPSSSGVQEAGLNVSSATDTTTTMASNIRNKISVCLSYINGFKNKFVMGTYGKRWTVADKENPPKTCNKEDGAECTTSDVYILEPYLPVVPKFTSYNAGDFNSELVKSFSLLQHYVIALQHLFLDQVFYRGSYMTQVDSTARYLEGILDYLKDCVLTQGLVPDNLVTRSLQVIYRRESDQGKRNVRDFVFLRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J8X5</accession>
    <name>A0A8J5J8X5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 1A-like 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Arpc1a-L16</name>
        <name evidence="6" type="ORF">Hamer_G028970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046751">
        <property type="protein sequence ID" value="KAG7153536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J8X5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7153536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="70" mass="7734" checksum="889239BA27F9CA1A" modified="2022-05-25" version="1" fragment="single">MFKASDLSQFVPEKVALSLNNNEVNIYGRAASEWKLQETLQGHDLRVTGIDWAPSNNRIVTCGAVSLLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J9G6</accession>
    <name>A0A8J5J9G6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase 4 regulatory subunit 3A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Ppp4r3a-L</name>
        <name evidence="5" type="ORF">Hamer_G019505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMEK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046868">
        <property type="protein sequence ID" value="KAG7153449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J9G6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="109"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7153449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="410" mass="46847" checksum="8F499038B1D7CB0F" modified="2022-05-25" version="1" fragment="single">LKQSPMSSIIHLSTITVSTQFRYVERLKGMSLLVRAESDGSLLLESRIQADTAYQKQQGTLIVQGKDPSVDITQDIVEESEDERFDDVSDSNPWVELPPCEIGRLEDINELAIALENEGYVKKLVSVFHTCEDLENMEGLHLLYEIFKNIFLLNKNALFEIMFADDTIFDVVGCLEYDPSSPYPKRHRQYLKSIAKFKEVIPIENSELLSKIHQTYRVQYIQDVVLPTPAEDERFLSELFHQLGGDEDIPTEKRRDLVLFLKEFCTFSQTLQPTSREAFFKTLSSLGVLSALEITLGLDDAVIKSASIDILSYIVEFSPSMVREYMVQQQHKTEEEQYLLNIIIEQMVVDSDPEMGGAVQLMGILRILIDPENMMATVTKSERADFLAFFYKHSMHYLVGMYGATLVKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JAW5</accession>
    <name>A0A8J5JAW5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
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            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Romanova D.Y."/>
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                <person name="Greenwood S.J."/>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Romanova D.Y."/>
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                <person name="Greenwood S.J."/>
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            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
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                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039068">
        <property type="protein sequence ID" value="KAG7156476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHW5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06944">
        <property type="entry name" value="NR_LBD_Ftz-F1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000032">
        <property type="entry name" value="Nuclear hormone receptor FTZ-F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016355">
        <property type="entry name" value="NR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086:SF15">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FTZ-F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002530">
        <property type="entry name" value="Nuc_orph_FTZ-F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="8">
        <location>
            <begin position="164"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>a phospholipid derivative</name>
            <dbReference type="ChEBI" id="CHEBI:16247"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002530-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7156476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="398" mass="43914" checksum="819B357168C255CD" modified="2022-05-25" version="1" fragment="single">LSAVRADRMRGGRNKFGPMYKRDRARKLQMLRQRQLSHPGILPGGRHPTTSGVAITYSTPGYSSAPSHVHIKEEIQSPFLSSSTSSPDSSPSPMGGLGGLVAASSGTSGLVASGPVAPIIAGPDPTLWVTNTQSPAAGVTTGAPPSGGVGGGGGGGRAATGGPRVPLMIRELVETVDDQEWQASLFSLLQNQTYNQCEVDLFELMCKVLDQNLFAQVDWARNSYFFKDLKVDDQMKLLQHSWSDLLILDHIHQRIHNRLQDETTLPNGQKFDLLSLALLGTTQFADRFHTVLNKLVDLKLDIPEYVCVKFVILLNPEVRLLSDRRSVVTAHEQVRQVLMEYTAGMYPEETEKYQKILDLLPELHYIADNGEKFLYYKHINGAAPTQTLLMEMLHTKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JI71</accession>
    <name>A0A8J5JI71_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acidic amino acid decarboxylase GADL1-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Gadl1-L3</name>
        <name evidence="7" type="ORF">Hamer_G025677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040052">
        <property type="protein sequence ID" value="KAG7156115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JI71"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF12">
        <property type="entry name" value="BLACK, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7156115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="447" mass="50614" checksum="EEDF206C2EA34C83" modified="2022-05-25" version="1">MTHEQEETNGLGGLCGWESGPDPAHHAHFLRSALELLVDKAVLQSTDRNSRVVEWVQPDDLKKRLHLTLEDDPVTQGDLLKYLDEVISLDVYGLVGQWVTDALNPSVYTYEVAPVFTLMEFEVLSEMAKHVGYEEHDGLFSPGGSISNMYGMLLARYYRFPEIKKQGITGLGRLVAFTSIDAHYSVVKSAITLGLGSDNLILVNVDENGRMDVNHLKECITKAREEGGVPFIVCATAGTTVLGAYDPIERVSQVCQIEGLWLHVDAAWGVFLTRHVGLLKDCNSASAAYLFQRDKFYDTSYDTGDKHLQCGRRADVLKFWTMWKAKGTKGLTKHIEKLFTMSKLFADKIRSRDGFTLLLEPECTNVCFWYAPPSLRGHEDNPDYTTRLHAVAPRIKERMVKEGTMMITYQPLRERHNFFRLVLQNSQVNEDDIDYFVRQIEIHGSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JI83</accession>
    <name>A0A8J5JI83_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027882</name>
        <name evidence="2" type="ORF">Hamer_G029952</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035865">
        <property type="protein sequence ID" value="KAG7158055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010029382">
        <property type="protein sequence ID" value="KAG7161457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JI83"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7158055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="145" mass="14969" checksum="32DFD64412800795" modified="2022-05-25" version="1" fragment="single">MYGAVQWTVLRRRSSSSRGGGGRIGVVSGSDGGRASGYSATEMGAKGGASGVGYVPRGKSKEGDDQVLCIYLGGYEERKRHVDDGAGNNRGGCSIPRDSVFVAVVPVTGAEKKASCERIAVVPLTGVYGAEKMVSSECIGVCDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIT3</accession>
    <name>A0A8J5JIT3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Circumsporozoite-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CS-L5</name>
        <name evidence="4" type="ORF">Hamer_G011501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIT3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035316500" evidence="2">
        <location>
            <begin position="16"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="516"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7158817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="627" mass="70964" checksum="E04629B10369F19C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIT8</accession>
    <name>A0A8J5JIT8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GATOR complex protein Iml1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Iml1-L1</name>
        <name evidence="3" type="ORF">Hamer_G020287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038254">
        <property type="protein sequence ID" value="KAG7157004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIT8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEPDC5 C-terminal" evidence="2">
        <location>
            <begin position="262"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7157004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="477" mass="52807" checksum="9D8E1550BBB785E2" modified="2022-05-25" version="1">MSCNLQKAGGSGKVGGVYGNIGRRHSLGPQVCCLPSTTSSTSTTTTSTSITTTAGLLAGASGQNVAAFRERLGSNRVMERPRPRSGSKTDRFKFESGSREAHLDTPEMKSLVEPEEENKEEGLLKQAGLPAFTFVADATAWVCERVEGATTEVVAVELLQKMLKSELICHASGDRQHAFVHGFFLYYIITGSKDQDQVNSDPCTYRSEWHEVEVEPLGVKPGGVTATPRSTSPPTPCPAFLQPDLPLYFPWKGRFKLYRIGLLDLDCNNRSDRIEWGHLKHHSMYNPMQSFEMMTWQRKAQSCGLYLFPVPSDPFALPYSYNSDPLRGPILIPLNVACLSVAGAEPFAQFTSSTWGRRMHLFQEAILERFGFVPYVTETHSTEQNQYVHVTGNMFVMIHSPGTGVHSHLPYPLEALRSRTLTNPLTSTNSTQADYLYGVSSPHVEYFHRLIADLYSREISEKQVCGAVLGTDEAHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIU9</accession>
    <name>A0A8J5JIU9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="1">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Chst14-L6</name>
        <name evidence="3" type="ORF">Hamer_G015905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010038275">
        <property type="protein sequence ID" value="KAG7156971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIU9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="365" mass="41520" checksum="75CF6744BCE9BD74" modified="2022-05-25" version="1">MRNRIKVTKLGVFVVVGLVITFQLYNKTKRKFTTTSNGKFTNSTQMNRTKLIVSDVSTKYTQTFSEVSKALKNITDPLIYDKSMLPGGLYSDLWNNSSAITENALIVVNSHRNIKILNSKTTFGKYDNLMRKIKIENEERNDKKLVMPKLNRTVKFVEQKEKQHVPGPTMVEDTQNSGWGDRRDEFTRRASVVRSVCRQFKVTEGPVSKSSQVANYTGAYVERVYPNNFHLARSASTLACLINKVASTSLAVSLLKADRRPVPDQWSEATSPHSAAAVLKPQHVWQQLGLKQSGVPWSNRNERNGSSSQVNHYYQGLHPRLVARVYQRFALDFHLFQYDILDVFKEGGHCQTNDCTEMASYIRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJU6</accession>
    <name>A0A8J5JJU6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034224">
        <property type="protein sequence ID" value="KAG7159030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJU6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="59" mass="6899" checksum="3C5744EBEBAF3A07" modified="2022-05-25" version="1" fragment="single">MTEATSLPTPDDRRLHHHLHQMPGGYITTTTRRLHHHHHQMTEATSLHQMTRHITTTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JK69</accession>
    <name>A0A8J5JK69_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010040257">
        <property type="protein sequence ID" value="KAG7155893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JK69"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="64" mass="6487" checksum="BF0B84181487FD1D" modified="2022-05-25" version="1">MPIGGIYMSGGAGIIIYHEERDKTKWGSGMQGSGSGVRWRESGVRESGVEGSGVSGGSGGSQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JKX4</accession>
    <name>A0A8J5JKX4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxygen-dependent choline dehydrogenase-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">betA-L1</name>
        <name evidence="4" type="ORF">Hamer_G004199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JKX4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF208">
        <property type="entry name" value="RE36204P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7159555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="266" mass="29530" checksum="90CA28CEDA633727" modified="2022-05-25" version="1" fragment="single">VRTALARREVVLSAGAVGSPKLLMLSGVGPSQHLQEHHIPVVADVAGVGENFHDHPGVYGLTWIVNKNSAGNILSLVAPSSIKNYLTNGQGPLSVPLGFEAVAWLPSKEGDPLWPQIQFLFSSLPSVFDLGLTLTTAVNLRKDVLPGCEGLKEGSDSYWECYLRHMVSSAIHFAGSCKMGPVNDYYSVVDHNLKYVIRGCLPSQENKDQVLGDVKEIRYKERLLLRNSEKRRIKKKVHHQPKDLPSQRGSHDRHGVRWYDSEEHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLF9</accession>
    <name>A0A8J5JLF9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036095">
        <property type="protein sequence ID" value="KAG7157904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLF9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="87" mass="9623" checksum="70D5050F8FD9C93A" modified="2022-05-25" version="1">MNTWSWTQHLWYTTSTHSLRSALTPHASPLAPHASPLAPHASPLTPTPPYTPANNVYMEQAHTSPEINLKLTRSHGKLKPYMPTGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLJ0</accession>
    <name>A0A8J5JLJ0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="2 15">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Plcg1-L</name>
        <name evidence="21" type="ORF">Hamer_G018806</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="2 15"/>
    <dbReference type="EMBL" id="JAHLQT010036987">
        <property type="protein sequence ID" value="KAG7157735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLJ0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010634">
        <property type="term" value="P:positive regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000009">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000011">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057061">
        <property type="entry name" value="PLCG_EF-hand_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF159">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23583">
        <property type="entry name" value="EF_HAND_2_PLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 15" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="10 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 13" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="16">
        <location>
            <begin position="498"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="16">
        <location>
            <begin position="610"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="724"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="19">
        <location>
            <begin position="879"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="989"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG7157735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1194" mass="138351" checksum="FC54E4B02FC102CF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLJ9</accession>
    <name>A0A8J5JLJ9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aveugle-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ave-L</name>
        <name evidence="2" type="ORF">Hamer_G006559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLJ9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052268">
        <property type="entry name" value="SAM_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20843:SF0">
        <property type="entry name" value="PROTEIN AVEUGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20843">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="1">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="103" mass="12191" checksum="AB9A73F710AE23DC" modified="2022-05-25" version="1">MLTTVHILQGKLARPKPCYLWTTADVQKWFKRHCSEYFQLYSHLLILHDITGKSLVRMSEGTLIRMGIKHPEHLEAIWREILKLRLKADIQEMKEIEMSAIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JMA5</accession>
    <name>A0A8J5JMA5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ral GTPase-activating protein subunit alpha-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Ralgapa2-L</name>
        <name evidence="1" type="ORF">Hamer_G019289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010038152">
        <property type="protein sequence ID" value="KAG7157063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JMA5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="73" mass="8427" checksum="64F47115DFBB5E32" modified="2022-05-25" version="1" fragment="single">MFKKNATSSDVKKSLSKCLDIKRDTPTRLKHLRTVLDNTDAGELKSFLDVNYSPVFHVFYEAFITFEGNLKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JN97</accession>
    <name>A0A8J5JN97_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MRM1-L1</name>
        <name evidence="9" type="ORF">Hamer_G004048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JN97"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="8">
        <location>
            <begin position="162"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7159423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="367" mass="42663" checksum="84DCF7971F26F7DC" modified="2022-05-25" version="1">MFSKIFIRHASHKVYRLPPVKFRYANDIPSSTNKQAGELPRITSPVVTEKAEKTYRNIQNKSGWQNDKRKYYPNSSDDKPNNKVRSERINDNNNKYNDLDSENTKHYNPDKYFNHERKRSSQLNMKYANRHHTTDKILHLSKREMRNGKNNNKLNFEPVGELIYGVFPVLLALRAQRRKFHNIFYKKGNEDKNNKIQEILETGKKHSIKIHGLGGSEFKLIFKGDQAHQGICCDVSHLLFENLNTENFYHTMKPGESMNLNKTKENELVEHQPESSPGEDQERPHQLWLYLDRIQDPMNFGAVIRSAYFTGVDKVFTPMEHSCRISGVVSKASAGVAEVLPVYQVDDPVTFFSKLSDVMKEQEFPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNB3</accession>
    <name>A0A8J5JNB3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Coiled-coil domain-containing protein 186-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Ccdc186-L</name>
        <name evidence="1" type="ORF">Hamer_G007604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNB3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099518">
        <property type="term" value="P:vesicle cytoskeletal trafficking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038830">
        <property type="entry name" value="CCDC186"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911">
        <property type="entry name" value="CTCL TUMOR ANTIGEN HD-CL-01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="72" mass="8028" checksum="C5B1CE6B5DB72D7A" modified="2022-05-25" version="1">MRHGGIMASVYGSAPRDGSMTLELSLEINRKLQAVLEDTLLKNITLKENLNTLGDEIAKISRHQTQQPDTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPD1</accession>
    <name>A0A8J5JPD1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G008923</name>
        <name evidence="4" type="ORF">Hamer_G008925</name>
        <name evidence="5" type="ORF">Hamer_G008929</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010035566">
        <property type="protein sequence ID" value="KAG7158284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPD1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036433718" evidence="2">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7158278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7158280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7158284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="152" mass="15605" checksum="1ACDA2BDC7F0A6CD" modified="2022-05-25" version="1">MKVLVAALALVATLAVTGSAEPLPEADPGYHSGFRGFGGRSHGGFGGFSGRSHGGYGGYGGHGAYRGKRNAEANPQPEAEALAEPEADPSGGHVRYGGYGVYGGFQGIGQHHHHHGKRSADADPEPDFSRYGGFGGQPGGFGGFRRYGGYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPZ8</accession>
    <name>A0A8J5JPZ8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Rpl39-L</name>
        <name evidence="6" type="ORF">Hamer_G010844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPZ8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7162177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="35" mass="4431" checksum="2201CB5687AE2A32" modified="2022-05-25" version="1">MKQNRPIPPWIRNCTGNKIRYNAKRRHWRRTKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ47</accession>
    <name>A0A8J5JQ47_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G009979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
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            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037907">
        <property type="protein sequence ID" value="KAG7157149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQ47"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7157149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="188" mass="21074" checksum="18E912E8C0A38929" modified="2022-05-25" version="1">MLQVCSEGIFTQNESNPGRQKRNQNHEESLLSSMQQFKVFSSDVLLTSLHNVGTKDLAIDSPGFPLECQRTGKKYLEALVNDRLTIYNEQKTAVPRSNAPTFESLYEIVKNNKDKDKASILKDDRSVLQRLIVVYVADRSVDLQDVLKHELVNVPMSLAEMNGSRRTGTKSVLADILITSTDCPSTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQI8</accession>
    <name>A0A8J5JQI8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Cadherin EGF LAG seven-pass G-type receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G025564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027687">
        <property type="protein sequence ID" value="KAG7162587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQI8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035149379" evidence="1">
        <location>
            <begin position="23"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="194" mass="20477" checksum="AAA0CACE62D697BA" modified="2022-05-25" version="1">MPLSTVFLHYLLALSHCIGSLALSPSTVFPALSHWHCLPGTVFLLAMSSCTVSLDLSLSGTVSLALSSRHCLPGTVSLALSSWHCLPSNVFPAPSHWHCLPGTASTALSSRHVSLALFPGTVSRALSPGSLPSPGTVSLALSSCHCLPSTVSWHRLSLALASWHCLPGTVSLVSSLHQPHWHWLLHCCLPVTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQJ7</accession>
    <name>A0A8J5JQJ7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GRB2-associated and regulator of MAPK protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GAREM1-L</name>
        <name evidence="4" type="ORF">Hamer_G025021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027886">
        <property type="protein sequence ID" value="KAG7162270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQJ7"/>
    <dbReference type="OrthoDB" id="6076990at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025946">
        <property type="entry name" value="CABIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052281">
        <property type="entry name" value="GAREM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14454">
        <property type="entry name" value="GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14454:SF11">
        <property type="entry name" value="SERRANO, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12736">
        <property type="entry name" value="CABIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CABIT" evidence="3">
        <location>
            <begin position="64"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7162270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="601" mass="67826" checksum="7CB5CFF28C98BD9A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRZ6</accession>
    <name>A0A8J5JRZ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
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            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7159944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRZ6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="29" mass="2758" checksum="545C453D3C2FA284" modified="2022-05-25" version="1">MLKVCERRVSVHTNIVAGGGSGCGGVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JS12</accession>
    <name>A0A8J5JS12_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tigger transposable element-derived protein 1-like 211</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TIGD1-L211</name>
        <name evidence="2" type="ORF">Hamer_G017330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7159898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JS12"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="1">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7159898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="161" mass="18165" checksum="B4DB1D0358718C9D" modified="2022-05-25" version="1" fragment="single">VLLISYAVELCTLGVTTTEQLPASTLFLAPHAILCVHLAVTRVLCLKIPSWLQIVFFEGGDKGSNEPKKSWRERKVLTLVEKVEIIKKIIESGMSYAAYARGYERKVTASVPATTKVTQHARDPALIKMEKALKVWIEDLNHRCIPLDSRFIWEKDALLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUA0</accession>
    <name>A0A8J5JUA0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G023288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028691">
        <property type="protein sequence ID" value="KAG7161950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUA0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="155" mass="16437" checksum="E9EE50833320894E" modified="2022-05-25" version="1">MRMDRRERKGMKSIDGGELAGTRAGGVKLVGLEGLAGVDSGAGGVRLVGLVGLAGLAGWWGWRGEAVGGVRDEVGWWGKAGWWAGGLCWWGEDGWLVRLMGLVGWRGEVNEDGGVRVRLVGLSGWWGDAGWWGEASGMRLVRLEAGGRPLEAHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUB9</accession>
    <name>A0A8J5JUB9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUB9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035191922" evidence="1">
        <location>
            <begin position="27"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="195" mass="21938" checksum="6EDB35565F483DF9" modified="2022-05-25" version="1">MVSRSWAEWAWLVSLLLIVHLHLNDAICSEYFNFPNEIDLSVLSGKWVTLASTRRVMPCHILHGHMESNSTLRLEEEWKVPGWATKAWNYSVTDRVVVSGNHLEVIQHGFDGLLYRGRVDVGVNGDKLLLVQCNPILWAPVPLITVLARTVPSIPEDDVRVVLDHFQVRRTSQAMTLIQHEGCDALTAPVTSVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUU5</accession>
    <name>A0A8J5JUU5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division cycle protein 27-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Cdc27-L1</name>
        <name evidence="2" type="ORF">Hamer_G014038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUU5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="447" mass="48039" checksum="79665BC345BABE71" modified="2022-05-25" version="1">MARCCFDLGKLEESETVLTGGSVLHPKTVDDLATEYGDLACFALQLLGLICARTERLMRAAEAFKRSLKLNPFLWHSFVALCDQGDKSDPSKVFRLDSLETFSNCHGSTVLTLVNSANPANNVSVNSDSGVLNNTLSSVSVNSQDTIQQTPAITPLQNTPNNILPVVNTPVQNLSNVNTPVPLTSLNTPVAVTITPTVDRSVGESGDGILQAPKKKKLVRIRSVMGGPLSLSPLTPSFGMLPLEMTSPMFESEQSSLNSSVAFLTPSPLSLSQLDTEPNTKVPPPISKRILCRNTKDSPLVLNKPAVFAPAGNNSNFQSPPTGQPNPSVRRSSRLFGNSNSVKENNKSRFVAPKSPARKTKTRSSKSQSSLSELNEKNKSENQDIISPADKPFPEKPATPQNLAQQALSIQKHSAATRLCILGKMKAQDLKVHPTSVNDVSTLLGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUY3</accession>
    <name>A0A8J5JUY3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G007824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027705">
        <property type="protein sequence ID" value="KAG7162310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUY3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="46" mass="5214" checksum="657B5F7DA1B30165" modified="2022-05-25" version="1" fragment="single">MRMRTSVTIVEAWRFVGGGTREQVKRDQLNGDQTVSDRLQGTSSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV41</accession>
    <name>A0A8J5JV41_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adult-specific cuticular protein ACP-20-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Acp20-L4</name>
        <name evidence="5" type="ORF">Hamer_G021024</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028818">
        <property type="protein sequence ID" value="KAG7161684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JV41"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035171506" evidence="4">
        <location>
            <begin position="23"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7161684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="217" mass="23825" checksum="4BCBFA4F82C26B91" modified="2022-05-25" version="1">MCAPFRQVLVMVTMGVVGVAAALPEDGPYGPVSGIYGQPDYRNDPLPYQFAYAIKDDYEGAHYQHNEKSDGSNVQGSYTVALPDGREQTVSYVADPYNGYLARVTYKGQAQHPNVYGSPVTFRPATYRPATYGPANNGPTYRPTTYGPDNNGPTYRPTTYGPANNGPTYRPTTYGPDNNGPTYRPTTYGPDNNGPITYEPDTPRPVITSYEPKLIYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV46</accession>
    <name>A0A8J5JV46_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposable element Tc1 transposase-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tc1a-L12</name>
        <name evidence="1" type="ORF">Hamer_G026174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032555">
        <property type="protein sequence ID" value="KAG7159729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JV46"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7159729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="104" mass="11584" checksum="DD1EE3E20A682ED5" modified="2022-05-25" version="1">MLKTTAPFIRVTQFGSGLGDIHISHFSHIHPDLNPIEHVWSAMNKYNIPSAGRHPTQDYVLTRALEAWEWLRGPKGLDLTSKLVASMPCRLNAVIEAGGGYTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWG2</accession>
    <name>A0A8J5JWG2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FH protein interacting protein FIP2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FIP2-L</name>
        <name evidence="2" type="ORF">Hamer_G020455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024193">
        <property type="protein sequence ID" value="KAG7165525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWG2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="298" mass="33629" checksum="30578DD3675EFEEB" modified="2022-05-25" version="1">MTSLPLTTTFLSVFNPTLTLLNMSHKHDYDLHMQGWPPFPSARVVMSLIWHESATSSQLSLTVLGFLKPLLGSFSPATSFLRITGAKMASYHKQRHLLSSTHGSPEQQGLGQRERERDIYSSHYNHTSLTSSHYNHTSLASSHYNHTSLTSSHYNHTSLISSHYNRTSLTSSHYNHTSLISSHYHHTSLTSSHYNHTSLTSSHYNHTSLISSHYNHTSLTSSHYNHTSLASSHYNHTSLTSSHYNHTSLASSHYNHTSLISSHYNHTSLTSSHYNHTSLTSSHYNHTSLTSSHYNHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZR4</accession>
    <name>A0A8J5JZR4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="11">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Lonp1-L</name>
        <name evidence="17" type="ORF">Hamer_G005074</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="11"/>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZR4"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000043">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000002">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.40:FF:000004">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="16">
        <location>
            <begin position="140"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="15">
        <location>
            <begin position="821"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="240"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="912"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="955"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="585"/>
            <end position="592"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG7164684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1006" mass="112551" checksum="F0501BA548DC66DA" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K023</accession>
    <name>A0A8J5K023_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Anapc7-L</name>
        <name evidence="2" type="ORF">Hamer_G019038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021370">
        <property type="protein sequence ID" value="KAG7167642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K023"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="236" mass="27094" checksum="FB77698F15B238CB" modified="2022-05-25" version="1">MRCLCAAWRPLWPECVLQRDFEGFEELEEEAVVHEIVSLGNSMGLEVDDDDVEELVEEHSKELSTEELLELHKEENETLKRSLTSEESGEDEDKEESRIILAKDLKDAIICWSKLSKLVEDYHPDVGSVQKAISVFNDNVMNYFWKDMRYEAAIELLRKQVAVQSTSRLHQMLADFFSHVHDEEKAAHHFGIALNHEPSNTRALEGMQKMEAAPDTVEAPPYDMEVEDIADSEVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K053</accession>
    <name>A0A8J5K053_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CENPB DNA-binding domain containing protein 1-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CENPBD1-L7</name>
        <name evidence="3" type="ORF">Hamer_G017317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K053"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7164909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="224" mass="24510" checksum="DE22BF64B7894E8C" modified="2022-05-25" version="1">MSPNDVALLLTTCMSPNDVALLLTTCMSPNDVALLLTTCMSSNDVALLLTTCMSPNDVALLLTTCMSSNDVAPLITTSTKTPSNVAKRSRVAITLDVKLDIVKRHEHGEGTSVIGRVHGLAPSTVHSIVKSANKIKEMAGSATPLTGTKVKRFHDAEMESMERMLSTWIDDQTQRLKTPLSQRMIQQKAVENNSFQCKLTAIRWLTTLAVVMRVRWLTTLAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1E5</accession>
    <name>A0A8J5K1E5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sodium channel and clathrin linker 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Sclt1-L</name>
        <name evidence="2" type="ORF">Hamer_G013059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1E5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045162">
        <property type="term" value="P:clustering of voltage-gated sodium channels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038911">
        <property type="entry name" value="SCLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35970">
        <property type="entry name" value="SODIUM CHANNEL AND CLATHRIN LINKER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35970:SF1">
        <property type="entry name" value="SODIUM CHANNEL AND CLATHRIN LINKER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="491"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="551" mass="63326" checksum="86DF9268D02DAF83" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2S1</accession>
    <name>A0A8J5K2S1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 14">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Sec11c-L</name>
        <name evidence="16" type="ORF">Hamer_G002569</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 14"/>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2S1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000003">
        <property type="entry name" value="Signal peptidase complex catalytic subunit SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S24/S26A/S26B/S26C" evidence="15">
        <location>
            <begin position="19"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7168492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="161" mass="18243" checksum="276E0728AE1B7BEA" modified="2022-05-25" version="1" fragment="single">LFYQVLNFAMIVSSALMIWKGLMVVTGSESPIVVVLSGSMEPAFHRGDLLFLTNYDHEPIRAGEIVVFKVEGRDIPIVHRVMKVHEKDDGSVKFLTKGDNNNVDDRGLYANGQAWLNRKDVVGRARGYVPFIGIVTIIMNDYPKFKVSFDFTRKFYLVGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3G6</accession>
    <name>A0A8J5K3G6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G021344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017879">
        <property type="protein sequence ID" value="KAG7169215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3G6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="86" mass="9349" checksum="BE9824947C39AE12" modified="2022-05-25" version="1">MKLVTLVVGVCVLILFLLLRQVSLVLALLLALSAVLTSVNADPVADPEPFFGKFKKHGKKGHGLTINTTDDFTTTRLSLFLTLCHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3H5</accession>
    <name>A0A8J5K3H5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G010410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3H5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7166754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="172" mass="20169" checksum="3965E6F664496E28" modified="2022-05-25" version="1">MCVLLVTAEHLDQVLQTAYNTYQDLENPIKVYGTNGETELNLGDPELMYIEWTIIATLLFMFVCTVVDVLLVIGAFRETPWMLLPWMVVQWITIFLTIALFGLVLWHELVAMPRYWWAVMFVVAVVILMILSFVLVLSLYQSIKEREMPEFYQGAELVHRHIWLSQKGKYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3T8</accession>
    <name>A0A8J5K3T8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G028167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010017311">
        <property type="protein sequence ID" value="KAG7169320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3T8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="41" mass="4741" checksum="CD2384D87BAE530B" modified="2022-05-25" version="1" fragment="single">IVRLRGERLTEVNLWLVENSSKQVKHFHSAIGVQCPDCQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5A2</accession>
    <name>A0A8J5K5A2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand calcium-binding domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EFCAB1-L</name>
        <name evidence="4" type="ORF">Hamer_G010258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5A2"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF60">
        <property type="entry name" value="CALAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7167853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="178" mass="20178" checksum="ABC5F31FFB90AD6F" modified="2022-05-25" version="1">MLALHDLTGTSPRMDGNRFRDIMHGIFGMTDEGLMEAMYQVFDMDQDGCVGPEEFVVGMSVFLRGSLDEKIDYCFSVYDHNGDGMVSRDEMFHQLKSAVVNLPPGEELDEVVKDMVDLVCRKLDMDHDGRVSFNDYATAVHAEPLLLEVFGPVLPDIQEREAFLNTFLEKYGLRSQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K619</accession>
    <name>A0A8J5K619_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G002357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K619"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="68" mass="7587" checksum="4D8DB960A227AEB3" modified="2022-05-25" version="1">MHGGGGQPAVSSEVLYVLQQRDYYLQRVVIMTGVLFGDESRLLDPQDHGHAGIVRWNMVSIFLGRPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K698</accession>
    <name>A0A8J5K698_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Neuropeptide F receptor-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NPFR-L1</name>
        <name evidence="13" type="ORF">Hamer_G002533</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K698"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF30">
        <property type="entry name" value="NEUROPEPTIDE F RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="329"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="548"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7168468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="618" mass="72117" checksum="634EFF7045156310" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8B5</accession>
    <name>A0A8J5K8B5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Polyubiquitin-C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">UBC-L</name>
        <name evidence="13" type="ORF">Hamer_G028319</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022204">
        <property type="protein sequence ID" value="KAG7166674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8B5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010623">
        <property type="term" value="P:programmed cell death involved in cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000158">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000160">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000469">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000009">
        <property type="entry name" value="Ubiquitin-60S ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="202"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="278"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="335"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="448"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7166674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="524" mass="59232" checksum="EF8473B72D4737C9" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8Q1</accession>
    <name>A0A8J5K8Q1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1</fullName>
            <ecNumber evidence="6">2.4.1.122</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Core 1 O-glycan T-synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Core 1 beta1,3-galactosyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">C1Galt-L9</name>
        <name evidence="25" type="ORF">Hamer_G022013</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="6"/>
    <dbReference type="EMBL" id="JAHLQT010019500">
        <property type="protein sequence ID" value="KAG7168700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8Q1"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000017">
        <property type="entry name" value="Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="24">
        <location>
            <begin position="85"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00059245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAG7168700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="357" mass="40533" checksum="A9B2960577B17001" modified="2022-05-25" version="1">MKRGTLLQILAAMMSGMVLSFLGVIPSLFIAPRKTRVANPLTHEDMDDELIPNDPLVDHNPQEIHHQGEDVEAVRLAEKVRVLCWVMTRPETHQKKAVHVKATWGKRCNKLIFISSQNDMNIGAIDVGAGDGRQLLWGKTKAAFQYVYQEHLHEYDWFLKADDDTYTIMENLRYMLSAYDPDYPIYFGSRFKKFTKQGYMSGGGGYVLSREALRKFVEEALPDEALCKISNSGAEDAEMGKCLDKIGVLAGDSRDSLGRGRFFPFNPIAHLTGSGLDCCSDTAISFHYVNTGKMYEMEYLLYHLRPYGIQHHDPFPAPLPPDRESIPLPIRQQIEESVSQDEQEPEVQIIHPELEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8S7</accession>
    <name>A0A8J5K8S7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTPase-activating protein CdGAPr-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CdGAPr-L</name>
        <name evidence="7" type="ORF">Hamer_G013438</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000002">
        <property type="entry name" value="rho GTPase-activating protein 32 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051576">
        <property type="entry name" value="PX-Rho_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729">
        <property type="entry name" value="CDC42 GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729:SF10">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN CDGAPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="95"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="484"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="580"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="944"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1332"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1627"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1719"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="580"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="605"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="960"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1003"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1334"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1371"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1422"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1433"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1460"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1499"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1627"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1656"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1696"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1756"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1773"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1815"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1862"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1940"/>
            <end position="1972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1982"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1997"/>
            <end position="2009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7170622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2029" mass="222568" checksum="D8D29B1600BF46FC" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K8X3</accession>
    <name>A0A8J5K8X3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G010545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K8X3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAG7166869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="40" mass="4760" checksum="755D8D98519CDDCB" modified="2022-05-25" version="1">MFRTVMCKGLFVRIIPLFIVLSEKYKKSIYYGSSLVKIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KFQ1</accession>
    <name>A0A8J5KFQ1_HOMAM</name>
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        <submittedName>
            <fullName evidence="10">Nucleosome-remodeling factor subunit NURF301-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">E(bx)-L</name>
        <name evidence="10" type="ORF">Hamer_G018945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
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        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG7170458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A8J5KFQ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016589">
        <property type="term" value="C:NURF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15560">
        <property type="entry name" value="PHD2_3_BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038028">
        <property type="entry name" value="BPTF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975:SF2">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="453"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="8">
        <location>
            <begin position="531"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="11"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7170458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="626" mass="69603" checksum="20C1891F21B042CB" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KFS7</accession>
    <name>A0A8J5KFS7_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G025441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010019665">
        <property type="protein sequence ID" value="KAG7168669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KFS7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF23">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17568" checksum="D1EB4D878AFE7FC0" modified="2022-05-25" version="1">MGVGIRYRLDGSLFNMRRLEASTKALTTQVIELQYTDDCAIMTHNRESMQLRLVCKLTPRTLEIFVQSIVPPIEAPQFYINGDPIKIVNQFKYLGGTLTPTCSLVMEIQTRINLASAAFGRLRTRVFLKYGTKTAVYLANLDALQTPYPNAGKLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KGC8</accession>
    <name>A0A8J5KGC8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Global transcription activator SNF2L2-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Smarca2-L2</name>
        <name evidence="2" type="ORF">Hamer_G013506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013773">
        <property type="protein sequence ID" value="KAG7170683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KGC8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="133" mass="15795" checksum="FF40E8B5CA121DDE" modified="2022-05-25" version="1" fragment="single">MSKKEVDYTDSLTEKEWLRAIEAMEEKEEEVTSSKNKRTSKGKRKQQDDLDNDDDPKPKKQGRPAREKPAPKNKRIIRQLKRQRRAEEEDDEEEEEDSRGKEGKKNKKDKSRGRRKRVKYADDSEDVDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KLF7</accession>
    <name>A0A8J5KLF7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fucose-1-phosphate guanylyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Fpgt-L</name>
        <name evidence="4" type="ORF">Hamer_G012256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KLF7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042350">
        <property type="term" value="P:GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012887">
        <property type="entry name" value="GDP_fucose_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15045">
        <property type="entry name" value="FUCOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15045:SF1">
        <property type="entry name" value="FUCOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07959">
        <property type="entry name" value="Fucose_pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GDP-fucose pyrophosphorylase" evidence="3">
        <location>
            <begin position="109"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7170034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="611" mass="68937" checksum="F2E1A1D2EBA21F79" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KQ45</accession>
    <name>A0A8J5KQ45_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-directed DNA polymerase from transposon BS-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RTase-L7</name>
        <name evidence="2" type="ORF">Hamer_G030821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012686">
        <property type="protein sequence ID" value="KAG7171219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KQ45"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="148" mass="16788" checksum="A82563BBEB56476D" modified="2022-05-25" version="1" fragment="single">PSYRVRGETDRQTDGRTDGRAAATDRRQHTQPPTALSHSKLNQDVSQQPPTDSTIDAPGIYTCDICVHLSSDNEDDGDALFKKRKIPEDWRIAYITANYKKESVSTSVICKLMESILRRDDIPYEKKYELFSNKQFGFISGRSTVLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKH0</accession>
    <name>A0A8J5MKH0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase F1 subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mai2-L1</name>
        <name evidence="9" type="ORF">Hamer_G023199</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044057">
        <property type="protein sequence ID" value="KAG7154744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MKH0"/>
    <dbReference type="OrthoDB" id="10045676at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000007">
        <property type="entry name" value="ATPase inhibitor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417:SF1">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7154744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="104" mass="11580" checksum="99BD993BD4585AE7" modified="2022-05-25" version="1">MALRATTVLRLRSPIALCVRGMSKGEPGSGSGQGGGTGGTIRDAGGSFGKREAAQEEQYFRKLQHQQLEKMRQGLKQEVKFHEDQIKAHKDAIKRHHERLDDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLY8</accession>
    <name>A0A8J5MLY8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminopeptidase NAALADL1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Hamer_G006012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039184">
        <property type="protein sequence ID" value="KAG7156291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLY8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="169"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="417"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="4">
        <location>
            <begin position="652"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7156291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="778" mass="86472" checksum="B3652462BC06F0A4" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MN55</accession>
    <name>A0A8J5MN55_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division cycle protein 123-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Cdc123-L2</name>
        <name evidence="3" type="ORF">Hamer_G028272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010037704">
        <property type="protein sequence ID" value="KAG7157252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MN55"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7157252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="330" mass="37888" checksum="3ABC6E13D2DA1477" modified="2022-05-25" version="1">MGLVLPEGSQPEPTYKRNTQEEEDTEDWDLCETSGCVVQGPKLEEYSTKIRDAIKKLGGSAFPKLNWSSPKDATWIALNSSLRCYTPGDVYLLLKSSNFVTHDLTTPFKDCDDVDVADPSVDYCLVLRRWMEINPAYEFRCFVRNKELVGISQRDISQGYSCVGGDQVNIRNDIISFWRENIDDRFPLHDYVVDVYRPVKDHVILLDFNPFGETTDGLLFSWPELKGLEDFRECLSRVIGDETSEEPEDNIQYHNERNVTDSNLQSYSPQRDKLICSSLIENSPEFRFISDATGVQPSPHKKYGLPMDLVDLSTIQDPKKLIDIIQMVYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MNM6</accession>
    <name>A0A8J5MNM6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036095">
        <property type="protein sequence ID" value="KAG7157925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MNM6"/>
    <dbReference type="OrthoDB" id="6343738at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7157925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="636" mass="73495" checksum="940747A4B4012980" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRU3</accession>
    <name>A0A8J5MRU3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bile salt-activated lipase-like 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Cel-L11</name>
        <name evidence="3" type="ORF">Hamer_G026513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030024">
        <property type="protein sequence ID" value="KAG7161092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2674"/>
            <end position="2696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2486"/>
            <end position="2521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="2698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7161092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="2698" mass="260744" checksum="05B9F8BFCA851483" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MS37</accession>
    <name>A0A8J5MS37_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fanconi anemia group D2 protein-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Fancd2-L1</name>
        <name evidence="7" type="ORF">Hamer_G007503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Fanconi anemia protein FANCD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MS37"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029448">
        <property type="entry name" value="FANCD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14631">
        <property type="entry name" value="FancD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7161843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="233" mass="26392" checksum="AC8C88F44C05B2E2" modified="2022-05-25" version="1" fragment="single">MSSRKKRKLIVNTDSDNTDDLVTSLQKSKKSRGKKDANESDTVQDDSLFGELVSKAGYMLKKGDQPNMLSCDQAMFQRDLRWSLRSHSIYRMPEIAEKFIQGLEDHIEDPVKLKWTLLYTQTVKNCVTARGGQQDSLIRMCLNIEELQPSLIKLLTEKLLEIANDDESSSQANLPNLVLANLKWLDHIIDSDTLTDKIVDILEGSPPKVQQEVICFVPNIVNDANHPRIAEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSX2</accession>
    <name>A0A8J5MSX2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent RNA helicase DHH1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DHH1-L</name>
        <name evidence="3" type="ORF">Hamer_G002097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7163040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSX2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7163040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="252" mass="26878" checksum="5B34F3362FC078F3" modified="2022-05-25" version="1">MVVSKDRERTREREREREGDGLLHQRSTGNTSTLSTSSSTSSSIMPYEHHVVFIPVGIIIFLICLTCRLCFYCRKRRSVVVHTLPVAITPAVHNTTVTTVHTGGTTYPQAPPGYPQAPAGYPQAPAGYPQAPAGYPQAPPGYPQTPAGYPQAPAGYPQAPAGYPQAPAGYPQAPAGYPQAPETYPQAPEGLETAPPAYSETAPPAYTLNQTAHASAPPSDPGSVPSQKKGFSLPQLLPSRFSNPYKPLDDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTE2</accession>
    <name>A0A8J5MTE2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027102">
        <property type="protein sequence ID" value="KAG7162741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTE2"/>
    <dbReference type="OrthoDB" id="7408914at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="241" mass="27145" checksum="F65616E1EEA5086A" modified="2022-05-25" version="1">MRAYSLPELAVLLCIRRRKSKRRTRIWMHELIPKRPNMDVKIEQDVGLDMEINETIYIKEEIETKEEPLLDGIPSDFEAKKTLSQQDTPADDTNVQSLLHYDGEDNNDTTQIIKSPPATQAKKEPKRKKAESEEDPRIEEALNILKGAAASASSQQDECGVYGQHVANKLRNYSKRTRAIVQHHMNNTLFNADMGQFDMETRPFSACPTTASNIPTLGSYHSIPTPESHSVHSSPAPTPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUS3</accession>
    <name>A0A8J5MUS3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G027554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025722">
        <property type="protein sequence ID" value="KAG7164092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUS3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="64" mass="7343" checksum="79F99100B974A66D" modified="2022-05-25" version="1">MNVHQYFAQEGSCETMEERSCVEDSLSNSGLYDHSGKNQGRSKEIARRSNMFAKCQTFTCRRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MVS0</accession>
    <name>A0A8J5MVS0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MVS0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="251" mass="28884" checksum="F79CCFE2886D3CC0" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAFETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXA2</accession>
    <name>A0A8J5MXA2_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit DAD1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Dad1-L</name>
        <name evidence="9" type="ORF">Hamer_G018336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7167915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXA2"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7167915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="120" mass="13614" checksum="57DDEAC5530BB1DB" modified="2022-05-25" version="1">MTRRSVMSSTTLTVVLKNFYDEYMKNTPKKLKIVDAYLTYILVTGVLQFVYCCLVGTFPFNSFLSGFICTIGCFVLGVSLRLQANPQNKIHFRGISPERGFADFIFAHIILHLVTMNFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY09</accession>
    <name>A0A8J5MY09_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Tigger transposable element-derived protein 1-like 252</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIGD1-L252</name>
        <name evidence="5" type="ORF">Hamer_G010159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY09"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035303334" evidence="3">
        <location>
            <begin position="23"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="HTH psq-type" evidence="4">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7167766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="187" mass="20720" checksum="BA2E8BE02638DB11" modified="2022-05-25" version="1" fragment="single">TSAKPRGQQSLIFNFCWWFITSTYITMPPKRPAAPSGSTPKRARRVLTLNEKNEVLKQLDSGMSYAAVGRHFGLNESSALSARLYDIDPSLDRSLKAKRAIENVMLPYIELQREMRSKKAQTTITNFFSRRVPAIAEPAGILQQEAEAADTSQQQDVEAAGTSQQQDAVPAHTPQEDADLDSSYSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY33</accession>
    <name>A0A8J5MY33_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G010229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY33"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="303" mass="34354" checksum="116E920A92B645DF" modified="2022-05-25" version="1">MEGERVKTKRSIFKSGEENKDAKKRLSFATHTASETTGDSPVVGSRRSITSIVPTNMKNRIQDLKVTPQKKGQELGTQDSSQLISQSELQENITIISPACKNIRRTTMGLCYVPKKMPEQPITQHKQTVLMRNNKKNNIHTVLHSIATPEPTVNILIIGDKILGEKIKASLLYQHSFQRTPNTIKWNLTLNILSYMSIILTKIDKAGVSCKQKLVLSVSSAQELHKNVIGLENFESFLDHHQLVYIPWEKQGRPSDHQVKKLLSLTYKSVGYYKDCSLLESYIMLRGVKDYQDDDTILQEGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYB1</accession>
    <name>A0A8J5MYB1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD repeat-containing protein 73-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Wdr73-L</name>
        <name evidence="1" type="ORF">Hamer_G011687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYB1"/>
    <dbReference type="OrthoDB" id="9822052at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042795">
        <property type="entry name" value="Wdr73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46947">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46947:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7168995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="355" mass="39132" checksum="DECE09AC1D9A2F90" modified="2022-05-25" version="1">MEKFDSEESDDEWFFESIKRYEDLLMYDVQGFVTCATFSGDDRLLLAVSREHLHEVWELSIPDKVVARKDAGLVRNRDFTLLAAGYTGSLVKQMLYVSAGVVTSGSCGIYLYSIPQSKDESDVISLNSILRSDVKDATLALSGATVYSGTSLSSISSFNLNSQAASDLPEICNNTTNSSTWGCNDMISNMSCVSEKLFIGLRDKGNVLLCDPRTGRVAQEIVVPESSGETWTMDVSCDGGSVVIANSCGVLNVFDLRNNIKSIFATSMKVQKKKVVNHRVCISPGDSLLSVSGYDKHIQVFNLKIPETNGESIFSHDGHRGHNVQNIVTHLWHPTQKKLLFSADDTGKLQAWRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N003</accession>
    <name>A0A8J5N003_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RING finger protein 145-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Rnf145-L2</name>
        <name evidence="12" type="ORF">Hamer_G016091</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014436">
        <property type="protein sequence ID" value="KAG7170288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N003"/>
    <dbReference type="OrthoDB" id="4348522at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16476">
        <property type="entry name" value="RING-H2_RNF139-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025754">
        <property type="entry name" value="TRC8_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF191">
        <property type="entry name" value="RING FINGER PROTEIN 145 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13705">
        <property type="entry name" value="TRC8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="613"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="658"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="692"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7170288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="742" mass="82582" checksum="875DC31211D71720" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1V9</accession>
    <name>A0A8J5N1V9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Synaptotagmin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SYT-L</name>
        <name evidence="2" type="ORF">Hamer_G025784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011974">
        <property type="protein sequence ID" value="KAG7171697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1V9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035325166" evidence="1">
        <location>
            <begin position="21"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="194" mass="21044" checksum="B97ED8927027D853" modified="2022-05-25" version="1" fragment="single">MFHGRGMASVWFSWSGVATALSPSKRGELGLQYNYKEAAVYVLQCRDLAAVDSKGTDPIRDGLGVIRLVMDQLDDGPVDDGPVGDGPVGVDQWMMDQLVMDQLVMDQLGDGPVGDGPVGDGPMEPLEDLIYSLRGDLILALKFVPPDAVSSKKTRRFGRFTCLLVAEHVSTIALIDKLLLSWDHSRVSSIAEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3F5</accession>
    <name>A0A8J5N3F5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G006882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3F5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="428" mass="45410" checksum="43831F0A2DE4468F" modified="2022-05-25" version="1">MTSVMSLRQLLCHSHSCYTTHADCSLARGCLVDTDIRRSRDHRFGPRTDRSRRTPAHSVPLHMLYSRHIVLSSKSSGAVLDAGASGSMAGGTVGTLALLLAPVTPKSRPAPLRAVDPHVARLTLTRTCLRGVRVRQQMGEAGGGVMSPVMASYLVMASSGGIDVKSDGTLPPHGGGWEALMSKVMALLPHGGSRWERCLRWSGRKGKAVGAEGVSGATGAGVAALSVDTLLLAPVTPHTALVHVLCTHHHVRPAVSTQLITSETDTLVGPWGVSALLAADAGCLALILVDAGFLVVVQIVPLPAGASHPPLVDMTAVVTASIVNRTRVEREKKERKKARKKERKKERKKERKKDPVPENHLSTTTTPPPLSPPPPPSPSPTHPGIDSTQAALGHQGEQPWAINQVAAIFAHRHHSPSLRQSRGGRRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N406</accession>
    <name>A0A8J5N406_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Superoxide dismutase [Cu-Zn]-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Sodc-L1</name>
        <name evidence="2" type="ORF">Hamer_G006825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N406"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910:SF1">
        <property type="entry name" value="SUPEROXIDE DISMUTASE COPPER_ZINC BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="1">
        <location>
            <begin position="201"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="324" mass="35025" checksum="5CE4980455D6FA0D" modified="2022-05-25" version="1">MLGCSRLFRSQPRRAVAHFTPTTVGGVGGRVEVYQVSPLDHVKLSINLTLPRGNAAAFGIDNFAIGDRISCTGLSRRFYEPWYVDLDLTPAPQQGTKDLYPAGDLSGKFGTLISLKEAAATLTDPTITLFGEHSVIGRGVAVYDPSWRVVGCADLKSEVPQVNAVAVFSGAISGVLRLSQPMDSIFSETIVYLRLYRTGGKDSAGHTWHIHTQSLDENGKCSSAGGHFNPFFTNLTDRQKYNGTPLPHTAYEVGDLHGKHGEVTIPGPRTSQRDLSSGRYQWTDEWLPLLGEASVLNKALVVHDADGDAARVACANIVMEEITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N471</accession>
    <name>A0A8J5N471_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G008473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7172970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N471"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="73" mass="8051" checksum="A0604FCBF35506FD" modified="2022-05-25" version="1">MTPHVQVWFVNGPMCPDRLSTELVAADALGESVNKYKAAAHCFPLSQSWHTSMTANWCSVYLPSLTLCPDMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N533</accession>
    <name>A0A8J5N533_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">28S ribosomal protein S9-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Mrps9-L2</name>
        <name evidence="5" type="ORF">Hamer_G023452</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009918">
        <property type="protein sequence ID" value="KAG7173427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N533"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7173427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="9520" checksum="669142E02FB9EF59" modified="2022-05-25" version="1" fragment="single">QVIFPLQFTGLLGKVDVVADVEGGGTSGQSGAIRYAVSLALRSFVDQDMVEKMRIAGLLTRDPRRRERKKPGWKGARAKYTWKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5F0</accession>
    <name>A0A8J5N5F0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nephrin-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Nphs1-L10</name>
        <name evidence="4" type="ORF">Hamer_G017994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009070">
        <property type="protein sequence ID" value="KAG7173705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5F0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="17"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7173705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="362" mass="40307" checksum="8C0254688B2BE4DD" modified="2022-05-25" version="1">MTFTWRCDSPTDVPGYPVITGYMTGEVLREGERRILICQVVGGNPRPWVTWYRHGRPINPTSMIAAPLTTPPAATSSTGMEETGVRVTQLVTATREEAGAVYESDAPTKVTVTTPSMAVVDQELTLACYTSAANPPATITWMIQGVELDSSSSVVSQEEGGGWVTTSELNHVVSGLHDTPQVTAECRAHHPATERAVTHQWTLKIAKRPGRPVLQVEGGGTEVIAGVTLKFLCTSDGGRPPPSLTSGMLMYLKKWDAHVPQKWDAPQKWDAHVPQKWDAHVPQKWDAHVLQKWDAHVPQKWDAHVLQKWDAHVPQKWDAHVLQKWDAHVPQKYHKVRTFLGGLVPVDYSLRLQWWNLLIKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6Q7</accession>
    <name>A0A8J5N6Q7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007499">
        <property type="protein sequence ID" value="KAG7174620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6Q7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="574" mass="62113" checksum="CFBC1A8FBF1EF089" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7D4</accession>
    <name>A0A8J5N7D4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box/LRR-repeat protein 16-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Fbxl16-L1</name>
        <name evidence="3" type="ORF">Hamer_G015308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7175086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7D4"/>
    <dbReference type="OrthoDB" id="10044893at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22127">
        <property type="entry name" value="F-box_FBXL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="403" mass="44412" checksum="E46611EC62BF5952" modified="2022-05-25" version="1">MSLTAQEVVERAGVELSKCITGLGLRSRSREREVREAPPGPGGSSGGGEGGRMGSVRRGGVMEKVANVLCGNSVASSGLVNGKGKMDKPVPPEKPSRFLLGKVRNGGVPTPPPGSSGTPFNGHQGSPRPLRASRSPAHLLRGHRYLSWDELIRDEAFLARFFMYFSPIERTVLAQVCLRWRTVLYQPKFWHGVRPVLNCREMRHTNVELTTDMRRRFYVSVQKRGFDSLVLMCANDEDLMDLVANYAVNHTKALRSVALRCSNISDKGLETLLDHLNGVYQLELQGCNDVTEAGLWACLNPRIVSLSVADCINVADEAVGAIAQLLPSLYELNLQAYHVTDAALAFFSPRQTSTLSILRLHSCWELTNHAVINIGQYGSYFLVYFIALITFVIGRRSSLTLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8D9</accession>
    <name>A0A8J5N8D9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7175057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8D9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="340" mass="36931" checksum="8491F4F3E7598FC7" modified="2022-05-25" version="1">MLPGGSSSTITTAPSVSCTTINPFSTTNSSPISTCSSTLVPCSPPPLYPLPVRHLSALLPLATLLPLAPLLPLAPPTSRPLPTSRPLPTSRPPPTSRPPPTTSSAHNFSPSTTRPPHNPSSASTLPPPCTSSPLHKLKTKANFSSPHSPQIPDSSILADKPGPHYNPDVPSIPNPANMVRRPYTCHTPYNDNNRTWTTTRHVPHSTKHAPYSCFRSRTDHSSTNAYITSPEFLSRVHNVALLMASQSSRVHDLPFARYFVPGSSLPQDLEEGRNPCLTPAPQLREAITPSLRQYCRSFMATMVCPQRVASQVMARMVSMETTAYHDHPHSKDAFVGRDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA07</accession>
    <name>A0A8J5NA07_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G015530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA07"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="74" mass="8332" checksum="409F4DFDB435EC82" modified="2022-05-25" version="1">MLDRPARDQYQRLIESRETIIGTRLTEDRIGTRGGRKITLKVGQEMNGADIVGRIPIVRIIAPPDPDQVHVTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA70</accession>
    <name>A0A8J5NA70_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G020788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004696">
        <property type="protein sequence ID" value="KAG7175719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA70"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7175719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="150" mass="16378" checksum="297D6D256E5EFDD3" modified="2022-05-25" version="1">MAAADEYSTTSHVLHLCLALQDRLEKVEKEVQSLKGENLALKLVLEEKKTFASVVKDGEVEVDSWKVVAASATKCTLKRHSAVDLNNRFSTLSDECEEGASNTTSATPSVSVERGSSAGSRDANWPCHLKSSDTHYTRFASAYLQLESAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NA85</accession>
    <name>A0A8J5NA85_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004571">
        <property type="protein sequence ID" value="KAG7175931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NA85"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="230" mass="26258" checksum="44CF13A5BACF5F4A" modified="2022-05-25" version="1" fragment="single">FIALRELARWVPTVVVSSWVHVVDDAEDVVLLSPRRAQLPQTIARAGRPSPAPVMEIQPQRHVRPPRTRANRPEVITSRGRIIGYHEAGKGIRENLSPSWDTVRLWGRRYEEEGHVLTRPRPGRPRVTTPAADQQIQRAAERASLSTAISQRSRVLFLSQSRFRTLAGWVLFNMRTAFGDASSDWSEMLLMYYLRQYGDYHLSPAPPHVSYTSPIPITRSRQQQPPPPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAJ3</accession>
    <name>A0A8J5NAJ3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase-like protein 7A-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Mettl7A-L1</name>
        <name evidence="2" type="ORF">Hamer_G009873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAJ3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="42"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="219" mass="24791" checksum="DD7BFF56D63334FA" modified="2022-05-25" version="1">MSRLTKEKDAKLEEVKKDLFASLGAIVSHDPQLRKNKAIKILEVGVGTGVNFSHYPNGSHLTVVDPNPHFVKYYNDNRKKFPNIHSQDIIVTTGEEMDQVESNSVDVVVMTLVLCSVGHTDKILQQILRVLVPGGKFYFLEHIREFDSEKYGIRQKLQDFLTETGIWPLLFDGCCLNRDMLSAINEAGFSSVIGERFYAPISNFFFKIIQPQLKGVAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAU8</accession>
    <name>A0A8J5NAU8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Insulin-like peptide 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Ilp7-L</name>
        <name evidence="4" type="ORF">Hamer_G015445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAU8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7176635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="224" mass="25487" checksum="9169D840826EC5CC" modified="2022-05-25" version="1" fragment="single">VVHAAADRGPLTRRRCQSYHWGSTTAGKNYRVMVVVIAAILVVVSTSWALEPYLIRQLESRTEAEWEVLWNKERLALCRARLRHNLEAICGKDVYRRSLTPPNHHHIKRSTDTCLKVHDGDGERDVRDKRAVSVNLPTATIEITPSSPDTGQHNINTRSPFLSVHQANLFVTTWVRGRRGSHYRRRRQSSSITAECCTTVGCTWEEYAEYCPTSSRLRPGVTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAW0</accession>
    <name>A0A8J5NAW0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G015462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003055">
        <property type="protein sequence ID" value="KAG7176650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAW0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13458" checksum="753F20AFF374FB71" modified="2022-05-25" version="1">MKCSAHVITVNDSIQKRSGNHNHAGDAAEIDAAKAMEKVKEHAINSQDTPHYIVSCASMEVNGAAAVKLPSVSNMKRTIRNIRARKNTGPALPNSYLDLNIPEEFTKTIKGDLFLIYDWSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NK13</accession>
    <name>A0A8J5NK13_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger MYM-type 1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G001919</name>
        <name evidence="2" type="ORF">Hamer_G030893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7162911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010000429">
        <property type="protein sequence ID" value="KAG7178256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NK13"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF23">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="35034" checksum="BC6F419D6C5923F1" modified="2022-05-25" version="1">MSGIYTGLQARIKAMNPLAYYVPCSGHSLNLVGTSAASSCLGSVSYSRFLQALYNFFSASTHRWDHLKAALPAEGIVVKSLSETRWGARADAVKAVFLHYRKIKSALENICSDSRQTVATKLEGESLIRQMEALETALLTVIWYKISTRFNATSLSLQKVETDLLSVVKLYESLISFVSEMRQGQFDEIEDQARAFAEPVYTETTKRTKKRKHFFDESVGTETQLDPHEKLKVDNFYTILDCLRNELEHRVNAYSEIKKLFRFLTEYDSMKYDDLKAQLELVVSTYSSDLEASVLDEFFAIQRHFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T1V1</accession>
    <name>A0A8J5T1V1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Cyclin-D-binding Myb-like transcription factor 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Dmtf1-L2</name>
        <name evidence="2" type="ORF">Hamer_G000728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7171810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T1V1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="257" mass="26765" checksum="0D0F8ED2D6214126" modified="2022-05-25" version="1">MCQQLYNMQSLSLLQSTLVELPATFLNSVTNATVLTAASATTPGNKSPTGSSQDCVSVGTIKLCIPAANFSHIINSDETEEDFGSRLSGLVQSALLAQSVDVRVCQSATVMVSQPQSFTSPTLTTQLTTELPQLSTHLTPTLSSGVKTQSIVVETMEDPMSIHLSGVTGTEVRHATLLDQGALGGGVKEEDILSDGEVSHSQTGLASSLDPSSPATTSQVILNDPILAVSGEPLGQEEGLQQENDDSDITCSGLSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T2V9</accession>
    <name>A0A8J5T2V9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G001027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T2V9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="207" mass="18100" checksum="FB6C703599300C8E" modified="2022-05-25" version="1">MGLTLLAASTYAEVSSFSTSSIGSGGYDSSGGGGFIGGGGGFGGGGVFGGGSSFGSFGGGGFGGGSGGGYGSSGGYSGATSHVSFNLGAPQRGYGGSSDGGYNSGSSIGGFSGGSLGGYGGSSGGGYGGSSSFDGGFGGASIGGGGYDSGFIGGGFGGGSIGGGGYDGGSIGSDFDGGSFGGSSSYNSGSFGGGSGGFGGGSSGYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T8U4</accession>
    <name>A0A8J5T8U4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FAM210B-L</name>
        <name evidence="2" type="ORF">Hamer_G025265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009769">
        <property type="protein sequence ID" value="KAG7173461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T8U4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="340" mass="37185" checksum="37A1765D200BA17A" modified="2022-05-25" version="1">MSRPYALANTSTPVPTPLTPVPTPQRPCQHLLRPCQHLNARANSLSTYMCQLPNYPPPDSYAALYMNQPPTCFLARVSAAPYTCHPSDSATHVLPDSKHVDTGQRTRGYRPANTWIQASKHVDTGPSTWMQELRGCRPANTWIRASKPTWIQASKHVDTGQQTRGYRPANTWIQASKHVDTGQQTRGYRPANTWIQASEHVDTGQRTRGYRPANKARFSPRRTRDVSSKLTQVGSLFGSGFMSGQGTQGGTFNSGTQPIDSHIDVYDSRITVSLSSAPVHLNMPGGQWAQDDKYISADLHDHHPMTVSSGKKPGISNAPLPPPLVGMWPSNAAAEGSGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIC3</accession>
    <name>A0A8J5TIC3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MKRN2 opposite strand protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MKRN2OS-L</name>
        <name evidence="3" type="ORF">Hamer_G015147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7174945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIC3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032016">
        <property type="entry name" value="MKRN2OS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053921">
        <property type="entry name" value="MKRN2OS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053922">
        <property type="entry name" value="MKRN2OS-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33963">
        <property type="entry name" value="MKRN2 OPPOSITE STRAND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33963:SF2">
        <property type="entry name" value="MKRN2 OPPOSITE STRAND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16044">
        <property type="entry name" value="DUF4796_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22795">
        <property type="entry name" value="DUF4796_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MKRN2 opposite strand protein-like N-terminal" evidence="2">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="MKRN2 opposite strand protein-like C-terminal" evidence="1">
        <location>
            <begin position="91"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7174945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="264" mass="29632" checksum="848386928D82D19E" modified="2022-05-25" version="1">MSSDNVEGRGDPVISERLVTWGLVEVDWGHFGIILETGVNWRSERDRVKMNLDPGIICYQHCEGRLFGFSLPSTCYVCDADLTTEPLNTPPFRVPYPFVRASQAPCTLVIKPSRGDFLHDYRSSSDLHIGVTDSEGCVLEYDSEGLHSDYTSAWTQTLSVPIITDATTNTVDPVWQEYWDFTLHTLARESTWSMERYSASSFNCYSFVLEFLQALGPPGLNVKNLTKTSLCAQLLVPHTSAAARYISLYRRLLTEKVVAVNKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TIP9</accession>
    <name>A0A8J5TIP9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative PAN domain-containing protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G001238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TIP9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF2">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="120"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7175215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="553" mass="61440" checksum="084198D16B3B9E46" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TJG5</accession>
    <name>A0A8J5TJG5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004778">
        <property type="protein sequence ID" value="KAG7175695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TJG5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="234" mass="27148" checksum="D4A4FFA160F72768" modified="2022-05-25" version="1">MPNKELINDMIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKRENNSHIDCGCPREKKFPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDLGDCSFYSRKVPPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERREVYRKFDLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TL07</accession>
    <name>A0A8J5TL07_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TL07"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="80" mass="9195" checksum="6C9879AEAEDEE970" modified="2022-05-25" version="1">MDPIPNWPPQTRLYGQPRKILLHIPFLDDASTITTGRIKTLRRKAVRQIVNEEGNEQPGASVSVRHSDKHCDIKILIRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLC0</accession>
    <name>A0A8J5TLC0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inositol-1,3,4-trisphosphate 5/6-kinase</fullName>
            <ecNumber evidence="3">2.7.1.159</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ITPK1-L1</name>
        <name evidence="12" type="ORF">Hamer_G008209</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ITPK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.159" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLC0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052726">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052725">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047325">
        <property type="term" value="F:inositol-3,4,5,6-tetrakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032957">
        <property type="term" value="P:inositol trisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008656">
        <property type="entry name" value="Inositol_tetrakis-P_1-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040464">
        <property type="entry name" value="InsP(3)kin_ATP-grasp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217:SF1">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05770">
        <property type="entry name" value="Ins134_P3_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp" evidence="11">
        <location>
            <begin position="2"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7177571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="218" mass="23618" checksum="AE7215335D66F462" modified="2022-05-25" version="1" fragment="single">TLSSVCKPVTAGGGVEAHEMAVVFNEKGISECTLPCVAQSFINHGAVLYKLFVLGPVWFVIVRPSLKNFYAGVDGCFDINKLAEQETVHFNSNNVSKADSQSPLTQLDPSDMKEDLPKADPAVFNRIVVDLRNALNMDLLGIDVVIDSSTGKYGIIDVNAFPSYDSVPNLMEHLVDLLVMRMNDSALANTTRIVESKSNSINMTSPDHPQEDSGVDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLL1</accession>
    <name>A0A8J5TLL1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor IIIB 50 kDa subunit-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Brf2-L1</name>
        <name evidence="7" type="ORF">Hamer_G000267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLL1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="744"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="777"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="812"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="849"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="849"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7177045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="881" mass="96274" checksum="C9F6346FF8AB79FC" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLR2</accession>
    <name>A0A8J5TLR2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLR2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="98" mass="11564" checksum="2B18C64B0C8F0C7F" modified="2022-05-25" version="1">MKRNTLRWYGHVLRMREDRLTKKVYDRKRERGMLGEVDQLPPGRKVFEILLMREREGKEDCLREQVRCARIKWPGDISAMATPCWGAPGREQGIGHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TQB5</accession>
    <name>A0A8J5TQB5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein 257-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Znf257-L3</name>
        <name evidence="13" type="ORF">Hamer_G027460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003419">
        <property type="protein sequence ID" value="KAG7176462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TQB5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390:SF244">
        <property type="entry name" value="LD33778P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7176462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="285" mass="33330" checksum="75B7385C39F48B53" modified="2022-05-25" version="1" fragment="single">MHTCTDEHIDDKISIKCEEFEESFNSDYDETRHVTADETVIKCEEFNECFSSDYDGTHHVTADVTDIKCEEFNESFNSDYDGTHHVTADVTDIKCEEFNESFNSDYDGTHHVTADVTDIKYEEFNESFNSDYDGTHHVTADETVIKCEEFNGSLNSDYDGTHHVTADVTDIKCEEFNESFNSDYDGTHHVTADLKDIKHTTEKNFKCEECGKSYYTKGYLKRHMVRHTTEKNFKCEECGKSYYTKGFLKRHMVRHTTEKNFKCEECGKSYYRKEHLKRHIYSCAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TSN5</accession>
    <name>A0A8J5TSN5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">5-hydroxytryptamine receptor-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Hamer_G024786</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002875">
        <property type="protein sequence ID" value="KAG7176747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TSN5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15331">
        <property type="entry name" value="7tmA_5-HT1A_invertebrates"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF200">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 1B-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7176747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="358" mass="40159" checksum="0CB65D792FC372BA" modified="2022-05-25" version="1" fragment="single">NVFVIAAILLERNLQSVANYLILSLAVADLLVAALVMPLGAVYEVSKEWTLGPELCDMWTASDVLCCTASILHLVAIALDRFWAVTKVDYIHQRSPKRVGGMIAVIWSVSFLISAAPMMGWKDPEWHERLRNKMCIISQDVGYQIFATITSFYLPLAVILVLYWRVYQAARKRIRRKIGTNAHSALCRGPVTISETTTFTRMSSQPSPEKTSNGSTLNGHPVDGGREDTTTSAVVAAVTSAAAAQVVPRHLRRREVESRKERKAAKTLGIITGAFVMCWLPFFILAVLMPLCTVSCHFNPYLIATFLWLGYFNSTLNPIIYTVFSPEFRNAFKRILCGRKRPFQRQSSRFSSVRFTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TVV8</accession>
    <name>A0A8J5TVV8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase WRNIP1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Wrnip1-L</name>
        <name evidence="7" type="ORF">Hamer_G003756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TVV8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="166"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7178008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="668" mass="74298" checksum="320DA52CCD43AD7E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TW06</accession>
    <name>A0A8J5TW06_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TW06"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7178068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="398" mass="44674" checksum="B1036E627C5BD325" modified="2022-05-25" version="1">MTGFHLVEEFNKTGQAFHYDPSSSSSSSSEEYQPSAPIPSSSGAPPLKRSRKTDIIKSPVVIEAMDRTNLSDRNAVFVAGAVAQALGHDIADMSFSRSTIRRYRASGRKQAAETDRKSFSPDEPLLLHWDGKLLPDVQNTTASRIAIVVTFNGQEKLLGVPKKERETGEAQAEACLEAIKSWNVEKLVKGLVFDTTASNTGLHRGACVRIEDELEQELVWIACRHHVLEIMLSDVFSLICGSTGSPETILFKRFKKQWRSISLNDFIPAPESIFWHEAPMAVRAPFNDLQLMKVLKEYPHEKVAHAAQAAISRHLWYLSEHLIGLSLFDDRIDTETKKNMVQNFQCPKKQDFSRRIVLPDETPISNVASFVTERTLDIFDVLTLDGKERAQLFLSSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JAJ2</accession>
    <name>A0A8J5JAJ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046276">
        <property type="protein sequence ID" value="KAG7153854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JAJ2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="184" mass="21017" checksum="BE2766FC2C560377" modified="2022-05-25" version="1">MTNKRHYNVVVKKNKNNTSPTTRLQQHVSYNNTSLQHVIYNTSPTTRPHNTSPTTRLLQQHRPYNTSPTTRLLQHISYNTSPTTCLQQHVSYNNTSPTTRPYNTSPTTRLPQHVSNNVSTTRLLQHVSYNTSPTTTHLPQHVSHNMSTTTRLLQQHVSYNTSSTTRPNTSTTTCPNNVSYNTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCE7</accession>
    <name>A0A8J5JCE7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044137">
        <property type="protein sequence ID" value="KAG7154544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCE7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7154544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="105" mass="12206" checksum="0CF2BD4F3ADDAE6A" modified="2022-05-25" version="1" fragment="single">MGLEVDDDDVEELVEEHSKELSTEELLELHKEENETLKRSLTSEESGEEEEDKEESHIIPAKDLKDAFFCWSKLSKLAEDYHPDVGSVQKAISVFNDNVMNYFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEU4</accession>
    <name>A0A8J5JEU4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="3">2.4.1.132</ecNumber>
            <ecNumber evidence="3">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ALG2-L</name>
        <name evidence="5" type="ORF">Hamer_G017524</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="3"/>
    <dbReference type="EC" id="2.4.1.257" evidence="3"/>
    <dbReference type="EMBL" id="JAHLQT010044465">
        <property type="protein sequence ID" value="KAG7154330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEU4"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="4">
        <location>
            <begin position="126"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7154330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="254" mass="28277" checksum="137083001F9A6189" modified="2022-05-25" version="1">MGNRGLPSLGLKGSRHIRVVFVHPDLGIGGAERLVVDAALALKRKGLCPFTAHHALPNLETWTQEKTTNQADCVLVNSHFTASVYKETFKSIKTSPSVLYPSLDFENFDKYESLTVRDVDLDVDSDCIFLSLNRYERKKNINLALHSMKLLLDMVNKDEASHIHLIVAGGYDDRVQENIEHYSELVSLATSLGISDKVTFLKSPSNKVKVALLRSARCLLYTPDKEHFGIVPIESMYVGTPVIAVNSGGPRDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGT4</accession>
    <name>A0A8J5JGT4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxal phosphate homeostasis protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PLPBP-L</name>
        <name evidence="3" type="ORF">Hamer_G019782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010036095">
        <property type="protein sequence ID" value="KAG7157917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGT4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7157917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="194" mass="21458" checksum="85DC41CCE18B24F5" modified="2022-05-25" version="1">MLRIMSEGEVARALKCVLARVSTATKGRRPDVAALGSQARLVAVSKTKPKEMIIEAYSAGQRHFGENYIQELVDKGNDQQILAECPDIRWHMIGHVQSNKVKKVVEVPNLHCIETVDSIKLATTINNAVQKNLGDKKLKRLLKCRAEVCEAQCMETKDVELSMGMSNDFEHAILVGSTNVRVGSTIFGARNVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JGV4</accession>
    <name>A0A8J5JGV4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Troponin C-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TnnC-L9</name>
        <name evidence="5" type="ORF">Hamer_G023681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041777">
        <property type="protein sequence ID" value="KAG7155395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JGV4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7155395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="161" mass="18069" checksum="09A76B100B6D8CB5" modified="2022-05-25" version="1" fragment="single">DMLDEEQIGATHCNTLTLYTRLTALQKAFDSFDTDSKGFITPETVGVILRMMGVKISEKNLQEVIAETDEDGSGELEFEEFVELAAKFLIEEDEEALKAELREAFRVYDKGGNGYITTDVLKEILRELDNRLTEEDLDSIIEEVDEDGSGTLDFDGERTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHS3</accession>
    <name>A0A8J5JHS3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Replicase polyprotein 1a-like 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">1a-L16</name>
        <name evidence="3" type="ORF">Hamer_G006780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHS3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7156764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="294" mass="32659" checksum="CE5F00CD348AF933" modified="2022-05-25" version="1">MMVPIIIQVVLQHSDEDDEGANNHSQVVLQDSDEDDDGANNHNNQVVLQDSDEDDDGANNHSQVVLQDSDEDDEGANNHSQVVLHDSDEDDDGANNHSQVVLQDSDEQGEGSTHHGQDMATGRANAPAVLADRGRIIGLWQGGMAPADVADAMGVSKKTVQRWITRWQEEGSLTTRPRSCRPRLGFITLRNTCGYVSLTPLPKFHHLWEQMLFPILQRRHLMPPCNTRHALSSSTPTTNFPHRVVLVNPYPNSQLPTIPNYPCCLDLPARIFTGFGTQTRLFWLSGQSGLWPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHV2</accession>
    <name>A0A8J5JHV2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Tubulin alpha-4A chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Tba4a-L</name>
        <name evidence="15" type="ORF">Hamer_G011246</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHV2"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000007">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="61"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="257"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7158597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="459" mass="51379" checksum="F5CD85CF844D2EF2" modified="2022-05-25" version="1">MTDRLNFSDKSECILIHIGQAGCQMGNACWELFCLEHDITPDGRMLSTPVIEEGYNNYHSFFHEVGSGQHVPRAIFVDLEPTVIDQIRNGPYRQLFHQDKMITDKEDAANNYARGFYTNGKKILNRTLESIRKLVDNCSSLQGFLIFHSLGGGTGSGFTALLMESLTVAYGKRTKLEFIVCPSPMMSTAVVEPYNAVLTTHTTIENAECVFMVDNEALFDICTNMLGVERSTYFNLNRLIAQVVASLTASLRFPGSLNVNLTEFQTNLVPFPRVHFPLVSYAPLHPAATAAFERLSVPEITKACFEHTNQMVKCEPQFGKYMSCCLLYRGDVEPTDVHAAIAEVKAHHTINFVEWCPTGFKVGTNSMPPVVVPGGDLSKVDLAACLISNTTAIGDVWAQIDHKFDLMFAKRAFLHWFMAEGMEDEEFMEARDDLSALEEDYKDLAENTYSLDRKNYSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHY5</accession>
    <name>A0A8J5JHY5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein 22-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Hsp22-L1</name>
        <name evidence="5" type="ORF">Hamer_G011337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHY5"/>
    <dbReference type="OrthoDB" id="6366277at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="100"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="422"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="739"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="1059"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="539"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="625"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="831"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="902"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="966"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1158"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="922"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1165"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1220"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1244"/>
            <end position="1260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7158672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1266" mass="142669" checksum="DDF19D6B0E019A5E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JJK7</accession>
    <name>A0A8J5JJK7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Contactin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Cont-L</name>
        <name evidence="12" type="ORF">Hamer_G006257</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034244">
        <property type="protein sequence ID" value="KAG7158880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JJK7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001529">
        <property type="entry name" value="Cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000035">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000005">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035156811" evidence="9">
        <location>
            <begin position="20"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="246"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="373"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="458"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="555"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="647"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="792"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="900"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="1007"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="1110"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="884"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="884"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7158880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1249" mass="142453" checksum="411036C4121F8492" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JK43</accession>
    <name>A0A8J5JK43_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Rpl36-L</name>
        <name evidence="5" type="ORF">Hamer_G011506</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JK43"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000001">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7158821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="130" mass="14776" checksum="717D2E8A3791AB1D" modified="2022-05-25" version="1">MYFIFVYITGKMAPRYEMAVGLKKGHKVTKNKREKKPSSRKGKITKRNKFVRDIVREVMGFAPYEKRTIELLKVSKDKRALKFLKKRLGTHIRAKRKREEMQRVMGQQRKAAAAAAAAAAAAAAATASHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLN5</accession>
    <name>A0A8J5JLN5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase MARCH5-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">March5-L1</name>
        <name evidence="7" type="ORF">Hamer_G001849</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLN5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20893">
        <property type="entry name" value="LD08641P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20893:SF2">
        <property type="entry name" value="LD08641P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="335"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7160562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="534" mass="58926" checksum="2FC45D0707B128F3" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNM0</accession>
    <name>A0A8J5JNM0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Msantd3-L2</name>
        <name evidence="7" type="ORF">Hamer_G004185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNM0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="6">
        <location>
            <begin position="137"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7159543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="556" mass="61609" checksum="BCBBD7120199BC60" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JNV6</accession>
    <name>A0A8J5JNV6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Tigger transposable element-derived protein 1-like 265</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TIGD1-L265</name>
        <name evidence="1" type="ORF">Hamer_G007513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JNV6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="139" mass="15646" checksum="06DCD6CB5591BB79" modified="2022-05-25" version="1" fragment="single">MAGFATLLMATKVTRFRDAEMASMERMLSKKAIKNISDSWEAITQHKMNSVWLSCGPSKAGFDEVDDADVEDLLDSHNGLTNEDLIELERLQQEEMTIATVEDADESPTQLLTVRNLRKLISSFEMAMDMALEMDPNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JPF9</accession>
    <name>A0A8J5JPF9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G010887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JPF9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032072">
        <property type="entry name" value="DUF4807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36693">
        <property type="entry name" value="GH02722P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36693:SF1">
        <property type="entry name" value="GH02722P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16065">
        <property type="entry name" value="DUF4807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7162212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="277" mass="32033" checksum="F70227686269D4E5" modified="2022-05-25" version="1" fragment="single">DPKMAGVVHMVVFAGTSHWDKLIVASSVAVTHSTTQSTWIFEDDCHGKESCHMSILNCSQKCHLNYNMNEILNIECIEKGMKKLSIKNSFKGIPQLKCKIYQQWLLKFKQKYSLDMINEHKEHLIIRWTLEDSMPYIIDYEWCNIMKRSVQEKQHLNTIMSWLSTLGGACSALGDYSAQFAERAGTISLQQLDIAFRLGDPLIVSRCRLYAAISLIQQHKFKLAAMVIKSEYHWAQSVAKEVRDERLMNMCLGIWTKLRHDRKLYLMKRQGLSAKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JS68</accession>
    <name>A0A8J5JS68_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LZIC-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Lzic-L</name>
        <name evidence="4" type="ORF">Hamer_G004368</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTNNBIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JS68"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.490">
        <property type="entry name" value="Beta-catenin-interacting ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009428">
        <property type="entry name" value="ICAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036911">
        <property type="entry name" value="ICAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040065">
        <property type="entry name" value="LZIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16505">
        <property type="entry name" value="PROTEIN LZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16505:SF8">
        <property type="entry name" value="PROTEIN LZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06384">
        <property type="entry name" value="ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81730">
        <property type="entry name" value="beta-catenin-interacting protein ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-catenin-interacting ICAT" evidence="3">
        <location>
            <begin position="113"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7163261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="182" mass="20611" checksum="CDCEAC905826800E" modified="2022-05-25" version="1">MASRGASETQKLRQQMEDQLDRLVAQLSDLEECKADLDEEEYEEVRKDTIEQLNEFQSSLSRMTSGDMTLVDSFNAMQLAIQAAISQAFKTPEVIQMFAKKQPDQLREKLSQIERDQKIGKLPVEPYTQQKVEILSALQKLGVSLTAAEQSFLDSHGSSLMKNFDQVTDETGSSQRSWRCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSV0</accession>
    <name>A0A8J5JSV0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Timm44-L</name>
        <name evidence="7" type="ORF">Hamer_G024209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Tim44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029718">
        <property type="protein sequence ID" value="KAG7161155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSV0"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017303">
        <property type="entry name" value="Tim44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037871">
        <property type="entry name" value="TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="6">
        <location>
            <begin position="310"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7161155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="440" mass="49834" checksum="4ECE82344096E604" modified="2022-05-25" version="1">MAASIVRSCRHVPTAGLRGYSMAKMWVPVSWSRGEPGVEALAATIKSHHQVSRSLQVQRFYSATPPPQKPPTFFGKIMENLRDEMGRNQKMKESLKEFRKDMQKLEQSEALQKVREKYQTVEDETAEGSKKAKQQLYTIKKRVSETVEEAQKAEIIQKASKLTEEATKQAQKVGQTISQKSEELSKTQTYKTISDTAKAVKEEIDHSTFGGAGARVYKAPVSLRKRVQRDPEAEKRIIQANAEARGVTLHKDSQFANSWQNFKDNNPYVNRILVWKTKLDESDNPLVRSSMLVKDKVSELFGGVFQRTELSEALTEICKMDPSFDRERFLVECEYDMIPNVLEAMIRPDLEVLRDWCFERAYSVLATPVKQAYQLGFIFDSKVLDVDNVDLVMGKVMDEGPVLAVSFQSQQIMCLRNSKGEVVEGDPSKGAESAVCWVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTD1</accession>
    <name>A0A8J5JTD1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">MAGE-like protein 2-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Magel2-L6</name>
        <name evidence="14" type="ORF">Hamer_G020805</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026066">
        <property type="protein sequence ID" value="KAG7163891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTD1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005041">
        <property type="term" value="F:low-density lipoprotein particle receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF5">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035206326" evidence="12">
        <location>
            <begin position="27"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="897"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="31"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="717"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="719"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="844"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="665"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7163891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="919" mass="101774" checksum="CC536656342355B1" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUJ1</accession>
    <name>A0A8J5JUJ1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027293">
        <property type="protein sequence ID" value="KAG7162716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUJ1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="273" mass="31229" checksum="1DFC21A5826E7F5B" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDSSSDEQEATSDDIGRLFVSFKKSSPINVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JV79</accession>
    <name>A0A8J5JV79_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MCM10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mcm10-L</name>
        <name evidence="10" type="ORF">Hamer_G005115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JV79"/>
    <dbReference type="OrthoDB" id="273123at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000174">
        <property type="entry name" value="DNA replication licensing factor mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015411">
        <property type="entry name" value="Rep_factor_Mcm10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056791">
        <property type="entry name" value="Znf_Mcm10_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09332">
        <property type="entry name" value="Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24863">
        <property type="entry name" value="zf-CCCH_Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01280">
        <property type="entry name" value="Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor Mcm10 C-terminal" evidence="9">
        <location>
            <begin position="562"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="606"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7164715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="901" mass="101048" checksum="A0774501C9DDC8AD" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW22</accession>
    <name>A0A8J5JW22_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Moesin/ezrin/radixin 1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Moe-L1</name>
        <name evidence="9" type="ORF">Hamer_G010882</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028013">
        <property type="protein sequence ID" value="KAG7162208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW22"/>
    <dbReference type="OrthoDB" id="6018897at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13194">
        <property type="entry name" value="FERM_C_ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000002">
        <property type="entry name" value="radixin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000013">
        <property type="entry name" value="radixin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011259">
        <property type="entry name" value="ERM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041789">
        <property type="entry name" value="ERM_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046810">
        <property type="entry name" value="ERM_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00769">
        <property type="entry name" value="ERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20492">
        <property type="entry name" value="ERM_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002305">
        <property type="entry name" value="ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="8">
        <location>
            <begin position="7"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="333"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7162208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="609" mass="71235" checksum="6D333C267EB953D1" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW47</accession>
    <name>A0A8J5JW47_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Insect pheromone-binding family, A10/OS-D-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G004582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW47"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="178" mass="20534" checksum="A892A2FEDC55A8CE" modified="2022-05-25" version="1" fragment="single">HSNQHYHPHLKLTLSASSVITTTKMRPSMTVVMVVMAMMVANVFCQEDNLVCTEQEETDLRALLRKGTEELYLPLLEETASGIRTLLSNQNTVRFHLDCVIHSKECTRIGKSLQHLITDNAGGELCYTCQPCQKRRIQHILKDLRCNYKPESDELEQYVLSERQINIYDFFQLKTITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW55</accession>
    <name>A0A8J5JW55_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G004599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW55"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7163451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="97" mass="11270" checksum="ECB5B80998C0318C" modified="2022-05-25" version="1">MPFRQLGYAGRRDVPSRDPVINFPARPPARRHHLVDCWYHSHQVRSKHLGTMEPTRCLSLTQGPCLNWLGKKGLTLTVLIRSQRVGYSQHLQRPNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JW71</accession>
    <name>A0A8J5JW71_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding protein spenito-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nito-L</name>
        <name evidence="9" type="ORF">Hamer_G004638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM Spen family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026473">
        <property type="protein sequence ID" value="KAG7163481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JW71"/>
    <dbReference type="OrthoDB" id="10050565at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12308">
        <property type="entry name" value="RRM1_Spen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12309">
        <property type="entry name" value="RRM2_Spen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12310">
        <property type="entry name" value="RRM3_Spen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21544">
        <property type="entry name" value="SPOC_RBM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000007">
        <property type="entry name" value="RNA-binding protein 15B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000565">
        <property type="entry name" value="RNA-binding protein 15B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010912">
        <property type="entry name" value="SPOC_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50917">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="297"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="378"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="SPOC" evidence="8">
        <location>
            <begin position="560"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="496"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7163481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="730" mass="80233" checksum="F927D90290C0BA56" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXX3</accession>
    <name>A0A8J5JXX3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Jerky protein-like 54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">jrk-L54</name>
        <name evidence="1" type="ORF">Hamer_G014066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029499">
        <property type="protein sequence ID" value="KAG7161424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXX3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7161424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="173" mass="19734" checksum="FC8A316D32BC28E0" modified="2022-05-25" version="1">MRLVEHCRSGQQWLVNLWRNSKWDFFRVQLNAADIEEWIHIDDDIEVAATFTDQEIIESITTPEKIEEKCSEESGEEDDKVEEKISWAAAEKGIETVIKFVEQNHSFSLQDVMHAHMVQNNLITKKLQSRKQGDIRKYLKKAVSSNAADTVEAASVPSTSSAADDIEVVEINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYX6</accession>
    <name>A0A8J5JYX6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G003705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYX6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="273" mass="30452" checksum="490F9107CBBE7548" modified="2022-05-25" version="1" fragment="single">MVDDLTPSTSPPRNREVLSKYNTIKNAWDRIVEAWRKINVAWKPLFANSEVSGAEQTEASGERQSVAATLMDRVEAALSVPAPGFSDVQVEDLQEIVGQHQQQPTIEEMLEEDEEQEEQQPTQEDDVKPGEPTTQQLTEMLLITITCLSEQLEEYNTRPLPQNLICPVLDKVMEEYKAMYMSRVNARQQALITRYLCKAQPVNALVSITLGDDDGIIDDDIEVLSDLLVEGLPQDFEGFDAEVRVGSREEAVTSPLCLGTHQPALSSISLIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZ30</accession>
    <name>A0A8J5JZ30_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028178">
        <property type="protein sequence ID" value="KAG7162024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZ30"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="69" mass="7394" checksum="6F014A9C0051FA43" modified="2022-05-25" version="1">MTHSPGVDDSPSDSLDDSPSVDDSPSDSLDDSPSVDDTPSDSLDDSMVLMIHLMLMIPMVTHLKLHDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0U5</accession>
    <name>A0A8J5K0U5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin biosynthesis protein CHS5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CHS5-L</name>
        <name evidence="3" type="ORF">Hamer_G021476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024416">
        <property type="protein sequence ID" value="KAG7165269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0U5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035325146" evidence="2">
        <location>
            <begin position="19"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7165269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="392" mass="41998" checksum="F100CDFE44EA889D" modified="2022-05-25" version="1">MRVWAVVVIWASGGVSLAAPGPSITTQSETPDLWDAARQTSRDTRLGIHYDKRDTLRLQGHQQETEGDGSLASAQQVTVITSQVSGAQDPVTNPLEIPGLFRGAKLPRGIVVKTVDEREKEEKETEEKKYGSHTFSDGPVRSETYSVASKLKQDKAVVTEDISNVTQKTALFTTETDPSSITALDGEEMTSSSEAASELLNTTSESSTTTNESMTASSESLTTTNEPLTTTDEPLTTTNEPLTTTDEPLTTTSEPLTTTNEPLTTTDEPLTTTDEPLATTNEPLTTTDEPLTTTSESLTTTDEPLATTDESLTTTDEPLATTNEPLTTTDVPLTTTNEPLTTTNEPLTTSSEPLTTTNESMTTTNESMTTSSESLTTTDEPLTTTSEPLTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0Z8</accession>
    <name>A0A8J5K0Z8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gastrula zinc finger protein xLCGF3.1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Zg3-L</name>
        <name evidence="9" type="ORF">Hamer_G012819</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0Z8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF53">
        <property type="entry name" value="CHORION TRANSCRIPTION FACTOR CF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7167371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="202" mass="22376" checksum="21EE9407F9B3D8E3" modified="2022-05-25" version="1" fragment="single">AGVGVRGSGDAVLCPVCGKIITGRNKRQNLQYHMITHTAHKPFQCPYCPHRANRSDNMKIHIRSRHLNQVQTQSGAADAVNAQRHMHVPIAMAKSVDVQLQGQSTGSAIKSPDGAIANDVPLMCFVCNKAFSGRNKRQHLSNHLNTHTGEKPFCCPFCPHRANRKDNLKMHMRLKHLENLPGNMGGDLLNRYQDPSTSHGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1Z2</accession>
    <name>A0A8J5K1Z2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoethanolamine N-methyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PEAMT-L</name>
        <name evidence="5" type="ORF">Hamer_G011971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25325"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:25326"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25321"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:25322"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023139">
        <property type="protein sequence ID" value="KAG7166034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1Z2"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000234">
        <property type="term" value="F:phosphoethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307:SF2">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7166034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="265" mass="30311" checksum="C180253C35592836" modified="2022-05-25" version="1">MSNKAASATQEFLDSSQYSLKRILRYERIFGHTWVSTGGETTTKDFLIKLGLRPGQRVLDVGCGSGGSAFFMARNYGVHVHGIDLSTNMINIAQDRLSREDKEVRDKVKLEVADTTKVQYNAIYDVIYSRDTILHIPDKEQLYKNMHAWLKPGGTLFVTDYCRGDRQHSKEFIDYVKQRGYDLRTVPEYGRVLEQAGFKDVQAVDLTQTFISVLTSELKYFEPTREAFILEYSVEDYNEIVGGWKQKLVRCAAGDQAWGMFIAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2D5</accession>
    <name>A0A8J5K2D5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018158">
        <property type="protein sequence ID" value="KAG7169157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2D5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="264" mass="30417" checksum="1A8C996773B1BA72" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKLTKLWHKAVETSLGKENLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDLGDCSFHSRKVSPINVNATKLSELVDLSLEVLEPPLITSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERREVYRKFDLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K2K0</accession>
    <name>A0A8J5K2K0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">All-trans-retinol 13,14-reductase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">retsat-L</name>
        <name evidence="7" type="ORF">Hamer_G007266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024345">
        <property type="protein sequence ID" value="KAG7165433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K2K0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052206">
        <property type="entry name" value="Retinol_saturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46091:SF3">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46091">
        <property type="entry name" value="BLR7054 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7165433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="476" mass="53807" checksum="63A1715500334748" modified="2022-05-25" version="1">MNRQSISKTYIDQITNGQLEWAPLSENYDTVIFAEKDKEPRKYPVLSGKGKWQEELTKKFPEEAQNIDKFFKLMKEIHPGNTKSILVKFIPLWAVWLLQTTGLINYITNFYEWNSKTCKEVVWGLTENQELRDIFCYCYGDYGTPPSKAGFPMQTLLHSHFGQGSSYPVGGASEIAFHIIPVIEAAGGKVLVRAEVNQIITDEKGRACGVQVLKGKELYNVAAPLIISDAGLYNTFERLLPLDVASSSRLWPMVQTSRHGTASMSVFVGINCDAAELDDIIHKKNAWVYTGNDIDKLLLDYEKLTREEALDVDIPILFISFPSTKDPEWNKRFPGKTTMALVTLMPYHWLEEWETERVMKRGDEYEAIKKCFGDKAVTQACNLFPSIKDHIDYVNIGTPLSNRHYLGAPRGEIYGLDHTSERFSVWNTAILRPSTDIPGALWGGLLCASSILQHNVMTDLTQLHQAIKAEAKAKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3C5</accession>
    <name>A0A8J5K3C5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G010434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3C5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035230730" evidence="2">
        <location>
            <begin position="28"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7166773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="574" mass="63159" checksum="81DA43FBD4CF27FE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3K4</accession>
    <name>A0A8J5K3K4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G031436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022044">
        <property type="protein sequence ID" value="KAG7166893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3K4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="38"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7166893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="406" mass="43404" checksum="E536DE152E541A31" modified="2022-05-25" version="1" fragment="single">ASKVKLLNAVSSQLLGDSVDISLREDHGEASQVNVVESRSVTDELRLLESQIKLKEAEAIARRVGIRQAEAEAKAKEAEAKAKEVGIRMVGLTKMRSWTRSPPNGASKFSTYPCSHCGKPGHKAEDCWTRLQLNTGKPAMIVTEETNTSPVEVMADLSKADSMPIGLVFTKGVVRESAVSVLASRDFDLFQESFAKDPDVGTFSPFLSQGTVEVDGVETPVTILRDSGCLQTLIKESVVAARKTDKYVVLGSLWGQGVAPLILVRVKSSCFSGIANVAFVHELPVAGVDLILGNDLAGGQMGNVTPPPVLREKPESTAELQQLEDDMPGVSPLCAVTRSMSMTKDHNATPVVDDSLSLEGLFANPIASQDISSAVNAVTGRVALIAAQEQDDSLRLLFDSGPTTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4D4</accession>
    <name>A0A8J5K4D4_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G022796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021714">
        <property type="protein sequence ID" value="KAG7167328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4D4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="649"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="86783" checksum="C9C111B97C38D750" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4L7</accession>
    <name>A0A8J5K4L7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposable element Tc1 transposase-like 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tc1a-L11</name>
        <name evidence="2" type="ORF">Hamer_G018035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015512">
        <property type="protein sequence ID" value="KAG7169785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4L7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="8"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="118" mass="13422" checksum="6689660F25D98CDC" modified="2022-05-25" version="1">MLAPSTDCHVVKEWLAQHPEITLLPYPPQSPDLNPIENVWSAMTQRMPMTHPRRRESVVMNALEAWEELGSTARRVLTTELLDSVPMRLSSLIEVVKRNLNKSSMMGVNLLDPVIRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4Q9</accession>
    <name>A0A8J5K4Q9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Complement component 1 Q subcomponent-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">C1QBP-L</name>
        <name evidence="1" type="ORF">Hamer_G010268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4Q9"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7167861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="261" mass="29357" checksum="23D369889FE120E3" modified="2022-05-25" version="1">MSMLTRALCRLQPRILPGVQVRNTVAPSRAITRSLVVLSSNRIVQDNIFLNSKLCSCGCGIHGMHTRGDRELVEFLREEIVAEKKSLKGSVPSHIDDFSVKVKDAEVILTKNFHDEKITVTLNVNHTVDSDETAEVNLDQSSEVALKSRPSFEVDLQIGSKTMSFTCSYTSPGDVVEGQDQVEDTFGINELIMYEGEWSEDNYCVSGDILDGMMYDLLMNMLEERGITNDFAERLSNVCSDYEHSLYVSLLQQVEDFVKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4Z8</accession>
    <name>A0A8J5K4Z8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Signal recognition particle 9 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Srp9-L</name>
        <name evidence="5" type="ORF">Hamer_G005483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRP9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4Z8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008832">
        <property type="entry name" value="SRP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017029">
        <property type="entry name" value="Signal_recog_particle_SRP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP9" evidence="4">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7167140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="55" mass="6487" checksum="18957EEE54160102" modified="2022-05-25" version="1">MVYVEAYEDFEKAAERVYLNAPMKCVQYKTDSQQELKKLEKLISNLMKHMASGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K5T7</accession>
    <name>A0A8J5K5T7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neprilysin-1-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Nep1-L3</name>
        <name evidence="10" type="ORF">Hamer_G024185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012650">
        <property type="protein sequence ID" value="KAG7171227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K5T7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="421"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7171227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="627" mass="71605" checksum="169511B59E2D5E93" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K601</accession>
    <name>A0A8J5K601_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Chitin binding Peritrophin-A domain-containing protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G012372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K601"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF106">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035303321" evidence="3">
        <location>
            <begin position="23"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="4">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="4">
        <location>
            <begin position="161"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="4">
        <location>
            <begin position="276"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7170131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="354" mass="40091" checksum="A24768DF739F699D" modified="2022-05-25" version="1">MRGLSSTWVWIIQVLVTGSVTGSVTSSVTRRFECPEAGNYSIRGSCGTFIECVPGQGGVLEPLQRTCDTNLAFSPFLNTCLEESLVKGCNKTMKGDEMKYLRKPSLDHICYDAPNQYMCANCKTLVNCVDGRAHATQCNTGNFCYNYNNEFGGHVCYPGRPTQCLCQDSNVFYRDAYDQGAFFICDESGENRMHQCPEGDWFDEKAVECRSFSGLPRCTTPGTFAHAEDCTRYYSCIVTTHGWLQHEYQCPYDRGVLFYNEQTGSCEDPCFWEKPRFECTQEGRFGDPTDCRRFYVCTWDAVAHKYRQVLRQCPSGFEWQQIVRNGSGRCTTMVTEDCIPVTNTRCIVPEGLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K621</accession>
    <name>A0A8J5K621_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G002458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020073">
        <property type="protein sequence ID" value="KAG7168416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K621"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="122" mass="13773" checksum="B074A76AF3427BE5" modified="2022-05-25" version="1">MSRRITTRDDIAAVIALYKANHELRDISAQTGVGLRVVQKLVKHHREFGEDVLPAPLPMSGRPKLFSPQKLEVISCQDKSNPALTAREVKERNPRLLSHVSLRCVRQSLYDALGFKSFRALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K798</accession>
    <name>A0A8J5K798_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K798"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="65" mass="7589" checksum="5B199A4B2962EFB4" modified="2022-05-25" version="1">MGFDELESEDIEDVLAPNTEKLTNEDLQQLTEHSPVEDDDDEEEPQRKLNSKRMAESFNMFQQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KAB8</accession>
    <name>A0A8J5KAB8_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zonadhesin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021820">
        <property type="protein sequence ID" value="KAG7167214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KAB8"/>
    <dbReference type="OrthoDB" id="6360232at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035191933" description="Zonadhesin" evidence="1">
        <location>
            <begin position="23"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7167214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="44325" checksum="E96C38EA435A3B42" modified="2022-05-25" version="1">MWRLTATLLVAALASASPQGYSYPVPDIYLPPSGSTPDCQAAPIISVEFTTRVQTSVNVQTVNQVNTQYITTTQVRQQVVPTTLYQTRVQTQVQYQTRVVQRTTNVVNDRVVTNTVPSPPREETRYVTSTRVVPQVSYVTRTQVQTQVVPVEVTRTQVQTVRQPVTNYQTQVQQQTRVVSVPGRDVVQTRVQTVVQTSVVSRQGPGNTRYVTSTQYRQQAQTSYVRGQNVYSTSYVQRQQVIPYTSVNTRYQTTYVTREQVVTRTNVVTQTQVQTQVVPQEVVRTQVVPTTIYTTRYETRVQPFTQVQTVVQTRYVTPAPVVQTQQQVQTSVVQVPGQNRVITQQVVQTQPRQEVVYQTVNQPRQVTVTQTITATCGQTGYNYDDPGTPFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KBU7</accession>
    <name>A0A8J5KBU7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-directed DNA polymerase from mobile element jockey-like 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G012391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KBU7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="222"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="333" mass="37062" checksum="0249D1BDAA884822" modified="2022-05-25" version="1">MQVAMAKIQPQNTTEAPQSTFLWGQQQQKTVNPTPTPPQMSEDSCSALPPPGCRTKLKTPGQNQSCTAVKAQNTRVMVENSILPGTLQPPQATTQLNTPQPANLQAAFTEEQIKQVVTIMVVTVSTIIKKQDTSTENITNAVMTQLTEEMQEDHTPKTPQLQVEQTTPLRAGARETATNEHTILNGRGGERLDHERREQLQHQRREDNDRIAPPPCHLKITQWNIQGLSNKRRTVQAAAIAKNMDVFILQETLMSKDEQFRLPGYQQYSVPKGPNSHGSMIFLRVTIPSSEVEPVHCGDGVEAQAVRIHLANDSLVVYNIYKPPPKRLEGGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KEL2</accession>
    <name>A0A8J5KEL2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxisomal succinyl-coenzyme A thioesterase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Acot4-L</name>
        <name evidence="3" type="ORF">Hamer_G023826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013298">
        <property type="protein sequence ID" value="KAG7170846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KEL2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000024">
        <property type="entry name" value="acyl-coenzyme A thioesterase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016662">
        <property type="entry name" value="Acyl-CoA_thioEstase_long-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014940">
        <property type="entry name" value="BAAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824:SF4">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08840">
        <property type="entry name" value="BAAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016521">
        <property type="entry name" value="Acyl-CoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAAT/Acyl-CoA thioester hydrolase C-terminal" evidence="2">
        <location>
            <begin position="182"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016521-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="388" mass="43196" checksum="00977477D10E183C" modified="2022-05-25" version="1">MTVHKGHLSDEALCSPVVGEPLATLTHLRHYMSPGVQRIPVRFGKVRGCLFLPPGNGPFPGVIDMFGSAGGLLEYRSAQLASRGFASLALAFFAYDDLPKHLEEFNIAYFEEAVEFLLKQEKESGEDEDKEESRFIPAKDLKDPFFCWSKLSKLAEDYHPDVGSVQKAISVFNDNVMNYFWKVFGDGVGVIGTSKGGDLALSMAAFIPSVHACIVINCCNTPSVKGLRVRDCFYTPLNHVFRNVRVSDEGVVFGKEIAQDPRLHPESIIPIEKSQSAFLFLVGSDDQNVKSEFFAQLSYQRLRDHSYPKHYEVSSYPGAGHLIEPPYSPHTPISFHNSYALPLIWGGTSKHHTLAQVQAWSKVLDFLRVHLAKGESISKHKCALKSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KEL3</accession>
    <name>A0A8J5KEL3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KEL3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="630" mass="70746" checksum="A1A9C8DD14847D5E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KFB7</accession>
    <name>A0A8J5KFB7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G019231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012889">
        <property type="protein sequence ID" value="KAG7171153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KFB7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035229446" evidence="2">
        <location>
            <begin position="24"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7171153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="424" mass="47514" checksum="DD18D1D0FE6AB39C" modified="2022-05-25" version="1" fragment="single">MRTFLAAAIVFCILLLVQETVLGERINRHEISNENHRVTKIGKDDNPDNDDARAGEVGESRQNREGVRSISGEGKRHRLKKIEKGKNNKNKATGRGVKSESKRENKLNEKQSRKLGKKQENKSGRRKNKEIKKKNKKGKGEKEEGGVKVKKTKTQRKIPKKPSKKGEKKQRKESKKYGDAEKKSNEGKNKSNTSRKTLKESRDKKKKITKKIKKSQSNYKKQKNSKNPKEQQAKISLKSDKRKSEHKTPKKSADKKDSSVIEKRKCVKRKPCTKVGGNCKKNGSCKTKVIEGKCKGGSCSCCLSKCAANPKHKCKIYKGVCKKKCGAKERKISNGCKKKKCVCCALPCKPKNKCKEHHGYCIDSKDHCPGWTDEKECKGKKCVCCYPEKMSRTTTTTTPTTTTTITAADSTTTTTATTTTTTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KJN9</accession>
    <name>A0A8J5KJN9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-ets-1-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ets1-b-L</name>
        <name evidence="6" type="ORF">Hamer_G013842</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012946">
        <property type="protein sequence ID" value="KAG7171055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KJN9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:001050">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF289">
        <property type="entry name" value="ETS-LIKE PROTEIN POINTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="253"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7171055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="361" mass="40618" checksum="A6EBFDA5E872243C" modified="2022-05-25" version="1">MVCWTLYGVKPQLRHSYSELIAVLEDIIASLSELSVLEELIASHSFSEFRVLEELIASHSFSEFRVLEELIASHSLSGYPSAESMGAVSEPPSEGSPGGFVTQPYTEADPEPYHTLPDSHHPAVHYLDPSAHDFYSLHDKYRLSYFKYPQPTATHRYPHEYSDGYSTPHYDPQFQTVPQALPEPWATAAAQGHDLSQINSGVGGPNLAHYLPARNDVVTPDTKPPPSLLGPSSATLGYQTGSGGPCFTGSGPIQLWQFLLELLTDKKQQQHISWTGDGWEFKLTDPDEVARLWGMRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYSPEELHAMVDLKPEKKDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJK6</accession>
    <name>A0A8J5MJK6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G017680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046276">
        <property type="protein sequence ID" value="KAG7153863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MJK6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7153863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="68" mass="7971" checksum="DE874CA7DBBFCB1F" modified="2022-05-25" version="1">MPPHNSVGFRLKYGRILPQEKVGLPPQNTARFCPRRQKHSTSEYGRIPSQNRVGFRPQKTVGFRPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK86</accession>
    <name>A0A8J5MK86_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arylsulfatase A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Arsa-L</name>
        <name evidence="9" type="ORF">Hamer_G018257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044460">
        <property type="protein sequence ID" value="KAG7154506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MK86"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF11">
        <property type="entry name" value="ARYLSULFATASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035322324" evidence="7">
        <location>
            <begin position="18"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="99"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7154506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="521" mass="57082" checksum="12717606D05DB2A2" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MKB5</accession>
    <name>A0A8J5MKB5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thyroid receptor-interacting protein 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TRIP11-L</name>
        <name evidence="6" type="ORF">Hamer_G017574</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010044465">
        <property type="protein sequence ID" value="KAG7154370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1439"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="36"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="513"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="674"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="734"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="899"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1155"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1439"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1493"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1514"/>
            <end position="1525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7154370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1525" mass="173182" checksum="9E25F04CB44A1C8D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MQ03</accession>
    <name>A0A8J5MQ03_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Vrk1-L</name>
        <name evidence="7" type="ORF">Hamer_G004135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010033114">
        <property type="protein sequence ID" value="KAG7159501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MQ03"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14015">
        <property type="entry name" value="STKc_VRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000931">
        <property type="entry name" value="Ballchen, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="49"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7159501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="650" mass="73225" checksum="135FD49BB2525A4E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRU1</accession>
    <name>A0A8J5MRU1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein 22-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Hsp22-L3</name>
        <name evidence="5" type="ORF">Hamer_G025472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030080">
        <property type="protein sequence ID" value="KAG7161076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRU1"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="136"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="372"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="630"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="723"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="732"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="755"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7161076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="771" mass="85731" checksum="428479A92E5FBCFD" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MS61</accession>
    <name>A0A8J5MS61_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MS61"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7161629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="193" mass="20975" checksum="8C1F5C18E2535E57" modified="2022-05-25" version="1">MPDVVMRTGEVKMLLSDKQVMSYKGLNTEKLVIKISVTSLDEDYSAMKAVFLLAVISAAVASRSYGGYGRRYGGRGYGFGGGGGGGGVVVAVAATATTALAWALARCQHRDSDENYYISQIISQQLSRVHWTGGFRNGYHFNWPSRNPFSGLNWSQTGGNGYPQPDNREDGRSSVWLCSTSTKTASWQCRLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSQ2</accession>
    <name>A0A8J5MSQ2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G019335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028140">
        <property type="protein sequence ID" value="KAG7162034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSQ2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7162034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="436" mass="48155" checksum="CB76B5A178EE4D5F" modified="2022-05-25" version="1">MHTFVGKTSQNRSQTAWPKGNTSTTSTNTIQQCQRPEDMLRGVVVLLALQGALALSQIKGRYHDSLPFSTCSFTRVDSTHPATYVTLKDNLVFALRPSTSLMHMRIMAQNTLYKATVHGTTVKLNRCSSEGQEDICFSLDEKATKGKDLLTPNQWNFVTVSLAADQLKVDINSQVDVMVMTMPDSSDGPYTSKVSIMAPDPTAKTRLSYSVDVNIKCNDTFTPELQTVNPEQNPVSTTNVPITTVKVPIPEPPHKNCPVYHVEHEHSTPNFTLNDELTLSIWPSHSMVYLRILIDDTLFKHEGSKSQDFLHPNTWNMIHISLKNNKITVDINMRANVTGINMPASSGGTNSGVVFIVADLNQKIAEQAYYLALVNIACDDSATEEISQPVGIIVGVLFAILAVVAIAIAISTYKKKRSVSINQHTPLNDQQQQIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTN3</accession>
    <name>A0A8J5MTN3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat-containing protein 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">WDR4-L</name>
        <name evidence="10" type="ORF">Hamer_G002791</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the Mettl1-dependent formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the Mettl1-wuho methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required for binding of nanos mRNA and repression of translation by the mei-P26-bgcn-bam-sxl complex. May cooperate with mei-P26 and nanos to derepress the BMP signaling pathway. May cooperate with mei-P26 to suppress expression of a subset of microRNAs. May cooperate with mei-P26 to regulate bam expression levels in germline cells during gametogenesis. Required to promote mitosis to meiosis transition during gametogenesis. May regulate germline cell division in part by regulating ribosome biogenesis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a heterodimer with the catalytic subunit Mettl1. Interacts with mei-P26 and weakly interacts with bgcn; required for the function or formation of the mei-P26-bgcn-bam-sxl complex. Interacts with nanos; may be involved in mei-P26-dependent derepression of the BMP signaling pathway. Interacts with Myc; the interaction may be mediated by mei-P26 and may be involved in the regulation of ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTN3"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="202"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7163583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="389" mass="44018" checksum="27D6D799AF24FB76" modified="2022-05-25" version="1">MGRIEVAHDFTVFCCGKNVLVYHSGSCETKILKVSNSSTKCKAKEENSDNANSVNSSTETQIMSVRISQDGQYLAVACETKVVTVWCTKTWTLLYTHSLVKRPMAIAITSDSATLLVADKSGDVYHLPLKGCKPDYDQASLSEQKNDEEGNTKMEEKPLLGHLSMLLDLAITEDSKYIITCDRDEKIRISHFPNSYNIQAFCLGHEEFVTQVDLLPKNKQFIVSCSGDGTLRLWNYVKGECVACMDTREHTAPLLHHYEKYIQQKIEESEEARRFLPDYPAVKSFTLYSDSSDEHLIAALVDRIPAVFLYKIEGTKFKYISTKELDAEPRVVSWLLSRELIVLQEEEEQPVCVLEFVDNNLHRVAEHALESLGKKQNHLFTDLNVTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU80</accession>
    <name>A0A8J5MU80_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polyubiquitin-B-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">UBB-L1</name>
        <name evidence="11" type="ORF">Hamer_G004949</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU80"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000160">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000469">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="146"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="353"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7164570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="443" mass="49516" checksum="A789181C54D5223F" modified="2022-05-25" version="1">MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKLDIPPDQQRLIFAGKRLENCRILSDYNIQKESTLRLIRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQRLIFAGKQLEEDCRTLSDYNIQKESTLQLRGGMQIYVKTLTGKTITLEVKPSDTIENVKAKIQDKEGIPPDQQILILRSSMESTRSKTEVWLIGQHITEITGAQLPSRGDVLRLFFHGHNEHKQTVNDSASEVAASVISFWNKARIPTITEKSIGRKVVDLFLMWKGLKKNCTRTTDTQRKKEETFCDELEDLFDVAHPKAMQLLTIKEDRAFLAAQREKGRRGVMAGVDKKIACSIKRREESKSKQSLQQNQASSALEYDELGSSSETESQSSSSSSTSSLAISPVVSSSNRKRATLKVITPELSSTLDRTGISHRSALRIIGGNIKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUH6</accession>
    <name>A0A8J5MUH6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Thiopurine S-methyltransferase (TPMT)-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G017287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024908">
        <property type="protein sequence ID" value="KAG7164885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUH6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="9948" checksum="973250346CB3AF3A" modified="2022-05-25" version="1">MGGFVYESLGNYVQIMKSLLAPDFRYLLNVTQYTPDEFFSGPPRNVPRELIEQFFVKIFRHFPNVINVFINFNLSLLVFLGWPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MUZ6</accession>
    <name>A0A8J5MUZ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proton-coupled folate transporter-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Slc46a1-L5</name>
        <name evidence="7" type="ORF">Hamer_G014442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026055">
        <property type="protein sequence ID" value="KAG7163984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MUZ6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="34"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7163984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="312" mass="34926" checksum="140D633C0222D3CD" modified="2022-05-25" version="1">MAQTQPQPEKRSLWRKFTDCLGTISVEPIMLLDGLAYSNMVVLVENLQMDKVCEVNLNQTREVCGNLSQHKEVKDSMSKEVSVFAMYNGIITAVIPLFFILFMGAWSDKYGRKVPLAVSTIGHLFYSLGYLVSSMVDTWPVEYLLAVALLDSLGGGTVSFLTAANSYISDVTSEESRTSRVGLANSIWFLGGPIGTLIGTYIYKAGGYQVLFGTSLSMYVVSLFYISFFLPESHGPFANVQKLEILPPKQSLRLRESVAWVYGIDKANKKKVMQTKSVLKRAKSITFGMMLRDFLNPRIHRQLQVHTEEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MV15</accession>
    <name>A0A8J5MV15_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">High mobility group protein DSP1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Dsp1-L2</name>
        <name evidence="11" type="ORF">Hamer_G005051</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HMGB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MV15"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21978">
        <property type="entry name" value="HMG-box_HMGB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000013">
        <property type="entry name" value="High mobility group protein B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF32">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HMG box" evidence="10">
        <location>
            <begin position="16"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="10">
        <location>
            <begin position="109"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="8">
        <location>
            <begin position="16"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="8">
        <location>
            <begin position="109"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7164661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="225" mass="25945" checksum="9B7AA373F2450B45" modified="2022-05-25" version="1">MPRGRPKGSGSTPDKPRGRMTAYAFFVQTCRTEHKKLHPDENVQFAEFSRQCSERWKTMSEKEKKKFHDLADVDKARYDLEMKDFVPPPGSRRGRRGRGTRQPKDPNKPKRALSAFFYYANDERAKVRAANPDFSVGEVAKELGRQWNELFEGDKLKYEKQAEEDRARYDREMTVYKAGGPLPSKKLKATNGHPVDVKHEDNDDDDDDNDIGPDDDDDDISDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MX31</accession>
    <name>A0A8J5MX31_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAM91A1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fam91a1-L</name>
        <name evidence="4" type="ORF">Hamer_G010542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM91 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022185">
        <property type="protein sequence ID" value="KAG7166866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MX31"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028097">
        <property type="entry name" value="FAM91_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028091">
        <property type="entry name" value="FAM91_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441:SF2">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14648">
        <property type="entry name" value="FAM91_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14647">
        <property type="entry name" value="FAM91_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM91 N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 N-terminal" evidence="2">
        <location>
            <begin position="124"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="3">
        <location>
            <begin position="255"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7166866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="741" mass="82008" checksum="57DFD3CCAC30E88F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MXN6</accession>
    <name>A0A8J5MXN6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Triple functional domain protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">trio-L2</name>
        <name evidence="10" type="ORF">Hamer_G010124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MXN6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF21">
        <property type="entry name" value="TRIO RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="75"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7167738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="423" mass="47669" checksum="6EB43FB9A968BE8F" modified="2022-05-25" version="1">MSGVEDPGYYILEEEEEEETNVKYEIKEASEKLENNEAEDNSDEDFKQAGDETEEPFADDTQIKIQWQSGFQRKYSVTHDLGRGRFSVVKRCQNLRHGQEVAAKFVRRGRQDQKETEAEFLLLRRLRHPSFTRSYALYTATPKFDILVMELVMGLPLLDWVFTREETTEAECAVLVVQVINALQYLHSCHVVHLDLKPENLLIDILRTSNNSDSCDIIKDEVQPAIRLVDLGSARHLMSPTQLANNTDVSSSASGDFFSKSDPNASDNDTSLLRVPSNQLPALFGTPEFMAPEMLGRNDVGVQADCWNVGVLIYVLVSGRSPFLGTSNEATCKNILSGDVRYPVEHFASVTQEACDLTRDLLVQKPTDRPNLQDILTHPWFNMNECESILPIQSLADFSFRRSKLASSMQEIPLTSAMPATSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY14</accession>
    <name>A0A8J5MY14_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerase I subunit RPA49-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Polr1e-L</name>
        <name evidence="6" type="ORF">Hamer_G010175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY14"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7167781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="301" mass="34110" checksum="FB041EBE8E4A77A5" modified="2022-05-25" version="1" fragment="single">FLVTFANGQPVEGAHLSGTLHQNITRDRRHQHKRILEIETPGLNYDGTNFGKEVSSLSAKQSVFLGILNKATGKMRLIETSSYCVHPVLESTKTTKALLKKSSDLLTFAEKQEAITSAFGSKRAQQSVNRRKLYQASRPEDVYQLESIAPDNFLAYMEDSARELLDGKDPDPKSTLLFKELLAVAKLEEDEENQVRLTCLALYVEYLVTFLNMKGRDIQHMKVKDKNLQGCPPMIKRHILDEYTHNHLNKRVRSSQNEDRAMCCAMVLSLIASKYQLSLSTLLSSLMVTRDKSNLKFQSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MY26</accession>
    <name>A0A8J5MY26_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Alpl-L1</name>
        <name evidence="12" type="ORF">Hamer_G010213</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MY26"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7167811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="476" mass="53220" checksum="1E166796B187F399" modified="2022-05-25" version="1">MILLAMAVPVYFGRHCDRYVWGPDYWNHLGWSDLQDALATATSHNWNIAKNVVLFLGDGMGIVVSTAARVYKEQKRQGNSGEEGYLAWERFPHTSLMKTYTLDQQIPDSAATATAFFSGIKANQYTLGVDNTVFRNDCFVTTTRLTHATPAALYAHSPNRDWECDAKLGRFGHGCRDIAKQLVEDAPGRDVKVMLGGGKFPFGASTGIADKKNCLRVDNRNLTHEWLIQKRAHGHKTEYVQNTQQLLTVDTSKTDHLIGLFSDSHMDYEIDRNRGPSGQPSLANMTSVAIKMLSKSRKKGFFLMVEGGRIDHAMHITEPLRAFEEILAFEDAITTALSMLDLSETLVIVTADHSHVMTINGYVKRGNDILGVSDKPSEIDNMPFTTLMFTNGLGYDYYWNDVREKSTTKHGYKPLSAVPMLYETHSGEDVAAYAIGPMSHLFHRMHEQSYIAHVMGFAACVGPYKKNCARPEHSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYY5</accession>
    <name>A0A8J5MYY5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018472">
        <property type="protein sequence ID" value="KAG7169103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYY5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7169103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="44443" checksum="6914DE2C6217A715" modified="2022-05-25" version="1">MPRRHRITSATDRERIIEAYRAEQDFLVVAAALGVQLTTAYSIVRVYQRENRVEAAHAGGRHKIIDNETLDLIVMLLEANPMMTLREIKEEVMDIFPTKPHFSEVTLSRYLEGELISLKMSRDSPAERNSPAVKEARHAYATWMLATGLQQQLVYIDETGFNLWTKRTYSRARRGERVHRAVGGQRGRNTTVIAAIAEHCGILYHEIHYGSSSSVYIHTIVEESESQLGENAKGTVRPTSSTTRSATEIYLVGQPASSIRGSKLPTMRQVLKFFFHTENESGDRQETFKKTVRNVLTFWNLARIKTISERGCREKLTRLWEHWRSLQKSRDRAAKDKVENFKSQLDLLWDIGAPDAVEDFEKNRLLTPADKQQDIASIKTNAEKKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZ14</accession>
    <name>A0A8J5MZ14_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine protease lint-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lint-L2</name>
        <name evidence="7" type="ORF">Hamer_G024484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016029">
        <property type="protein sequence ID" value="KAG7169535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZ14"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="16"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7169535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="258" mass="28606" checksum="8D31799BF7C14544" modified="2022-05-25" version="1" fragment="single">SLSACGVRPLAREGRIVNGERSDFAEWPWQALIKESTWLGIFTKNKCGGVLLNKRYVLTAAHCQPGFLASLIVVLGEYDLSDDYEPKKVIQRNVKRVIVHKGYVAKTFDNDLALLELEQPVNYDEHIVPVCMPNGDEDIVGKLGYATGWGRLSYGGPVPTQLNEVALPIIKNNQCQKWFSEAGHPKNIKPEFFCAGYKQGKKDSCEGDSGGPLSVQGKDGRWFLAGTVSHGIKCAYPNLPGVYMRMTSYKPWIEGIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0A8</accession>
    <name>A0A8J5N0A8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exopolyphosphatase PRUNE1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Prune1-L</name>
        <name evidence="3" type="ORF">Hamer_G020661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPase class C family. Prune subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013854">
        <property type="protein sequence ID" value="KAG7170570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0A8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="2">
        <location>
            <begin position="213"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="361" mass="40623" checksum="C5CA8D92F9832530" modified="2022-05-25" version="1">MSSFLNYLASTKRTLASQRHMGLHVVLSNEACDLDSAVSATVYAFLLNSLQQKAYVIPMPMSVIPVLNIAREEYSLKTEVVYWLGKYEIHPDILIFRNEIDLTKQHEIGLKLTLVDHHVLPPLDAHLDPDIVFIIDHRKLERTAVSVSGGMVVEPVGSCCTLVTEQILDKDSSVLKDNTIASLLYGTIVLDTVNFNEAAKKMTPKDVRIDRVFQDLVEAKTNVSGLTSEQLLRKDVKVVSSEDFRIGIASVPMMVKDYLQRKDVGRDLSKHCCRQDYQILVILGANHTNETIYRDMAVFSTQIDLRDELVLHLCNAEDRRLQLQPMGVNILGCSTFLQGNTAASRKVILPYVKDWLAKQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0J0</accession>
    <name>A0A8J5N0J0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G012395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N0J0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7170151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="165" mass="18972" checksum="A3FAE0F956A0A2D5" modified="2022-05-25" version="1">MESTRSKTEVWLIGQHITEITGAQLPSRGDVLRLFFHGHNEHKKTVNDSASEVAASVISFWNKARIPTITEKSIGRKVVDLFLMWKGLKKNCTRTTDTQRKKEETFCDELEDLFDVAHPKAMQLLTIKEDRAFLAAQREKGKKRCNGRSRQKDCLFHQASGRKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1C0</accession>
    <name>A0A8J5N1C0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1C0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="61" mass="6771" checksum="7AA81E044F562173" modified="2022-05-25" version="1">MGVGDSVGWVWVTVGWAECRLSWVWVTLGVAGLDVVFIDMMCGGMARRRRAGKEEEIGVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1F5</accession>
    <name>A0A8J5N1F5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G024972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012251">
        <property type="protein sequence ID" value="KAG7171396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1F5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="74"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7171396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="303" mass="32600" checksum="B58BB86ABF124186" modified="2022-05-25" version="1">MSHAARALLAPGVGIGSGYRADRDLVKSYKMKSTSIDEPKMETRVLMPAEFSLVVTARPLPPLDRLVPAEDCIKVCATRPLPIQTRYLPFSGTVRADNLPLLPYLPPMDVRSRYGGYDSVDEEGRRTCNWVRFLKVAPVYSHEVNLVGRRAGPRGDVVFEVVREILPGGELLAFLLPDMNGENALLLPALTLIRSSLYRRTIDSIMAEAPLDLSRSLLTSPPPRPTNTSALSRDSDAVSPSSSPSPSSSPASSTSSAPAFSPTASSMFHVGRSQLQFGLPPRLPMGLAPQSPSAMSTGSSSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1J1</accession>
    <name>A0A8J5N1J1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Clarin-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Clrn3-L</name>
        <name evidence="8" type="ORF">Hamer_G014664</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295:SF6">
        <property type="entry name" value="NEOSIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="46"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7172588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="463" mass="53595" checksum="C07DC2DFA6C31833" modified="2022-05-25" version="1">MSRGRDRGRRRTRSRSRSRSRSRGRNNSPGRRGVSDVTSDPKTVNARIFVGSINVSMTREMLEEYFSKYGKVVGVSITRNKFGFVQFADEDEATACLSTGSTAYIKGHRVDVKPAKFGGGMGMGPPPGARRRLGNSREKSPLQGRGEEDYYTEYYGRGTRSGSRERDRDSRGQADYEDMFDDYYRGYYQRYEDTYQQHPEAPEVDGRPPPAPVPAYPSYSEPIDPLDPNRPNDVEIVVPNKMQRDYAENIEAQLKSLNMIVDLLFPPPDIPPSQVLTDLSQRRCLYAIFVTGDNENHRSLTLNILHSTPQEHRNMPVDDALRLIEQNFGEYVKKARQRNIREVVPRDIRNLLHDLLEMRPLSMGDLDKLIKYLKERQSVLVDDQIEQKRETAAVMEVQPQGHMRPPRTRANRPEVITRRTRIVEYHEARKRIREVSRLLGISRDTVRLWVRRHQEEDHVLTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3R1</accession>
    <name>A0A8J5N3R1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G022710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010864">
        <property type="protein sequence ID" value="KAG7172504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3R1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052825">
        <property type="entry name" value="CCD-Prefoldin_beta-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34479">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34479:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="342"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7172504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="489" mass="56592" checksum="ED91FF295330F468" modified="2022-05-25" version="1">MDGDDSVIDDEWTGLRRRFSIEGLEWETQDPSSRTLHVWRWVVDAEANLKAARHINDKLRRQHDEEKVELEEYTELLRVKCEDRVKELDDEIAYLLVERSKLNEELTIARTRPASDREKDLTTQLIKASTDLELLKRTHQDTNCHLTEMTDRVSLLEKASRQLELDNETLAYKLSEALAEIEDNEGQLRRYSKNPHFRRGESPRTSLRSQEEYGASSLRSLPLADNVFSREDCQRRSFQRRDSSRNSGRQKKSEPLRPERGKSPRRRHSSRASSVGRDGVEAREATPHAEEGELAVSSLGKGHDVYGTRWNSIVSCGSASPKRLHSLLDDQIQTSRSQITMLEEVKKLKVELEKIKKDLVEAGDKYELIVRKYELYKIKSKSKVSSLKTNYQSELDTLKRRISQLEAEVNLQGDQLQGEESLRKQLEDDLSNIRTERQELAMRVRESERLASERSQEVSLLQEKVRLVQDMNKELNEKLQELSVAAIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N3W6</accession>
    <name>A0A8J5N3W6_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">U2af50-L</name>
        <name evidence="14" type="ORF">Hamer_G006803</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer with the U2AF small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N3W6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046660">
        <property type="term" value="P:female sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000074">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010519">
        <property type="entry name" value="Tra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06495">
        <property type="entry name" value="Transformer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="2 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0726">Sexual differentiation</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="206"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="338"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="453"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="42"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7172594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="545" mass="61466" checksum="89A8E88276964ED0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4L7</accession>
    <name>A0A8J5N4L7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G031623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010477">
        <property type="protein sequence ID" value="KAG7172825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N4L7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7172825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="78" mass="9197" checksum="96B303DAF2D8BB4C" modified="2022-05-25" version="1">MGLRFSHFFQIVRLRGERLTEVNVWLVENSSKQTPHKVKHFHSAIGVQCPDCQHLVQYDVTSGQLNLRRKSVQYTIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N4V5</accession>
    <name>A0A8J5N4V5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G023461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009918">
        <property type="protein sequence ID" value="KAG7173436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057435">
        <property type="entry name" value="Lips"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37686">
        <property type="entry name" value="LD36006P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37686:SF1">
        <property type="entry name" value="LD36006P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25228">
        <property type="entry name" value="Lips"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="679"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="764"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7173436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1344" mass="151293" checksum="8484D935BE5107F6" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N5D6</accession>
    <name>A0A8J5N5D6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-directed DNA polymerase from mobile element jockey-like 96</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009957">
        <property type="protein sequence ID" value="KAG7173424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N5D6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7173424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="186" mass="21232" checksum="422F8C90276EE08B" modified="2022-05-25" version="1">MPQEDSEGKQHLRHRQYITSNPPSGRTTHLRDSDGDEVQDSQRNRIQPCIRGSGSTGTRIQEHQVHCETQSSWRPDTLPQDHNTAKILSEVTNLNGKTVKIILLDPEEKTTRMVLLRYPLELPVEVIIKHSKVTKAERCVTSQDKAQTKQVLVDIKGTVPEEVDLGNWGTYKLRPFVPEPLRCYKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8A1</accession>
    <name>A0A8J5N8A1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G015226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006356">
        <property type="protein sequence ID" value="KAG7175016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8A1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7175016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="946" mass="106984" checksum="8E88497492729E3E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8L7</accession>
    <name>A0A8J5N8L7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G009951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
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            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004633">
        <property type="protein sequence ID" value="KAG7175911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8L7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="109" mass="12051" checksum="B340128780574B65" modified="2022-05-25" version="1">MTGPKVGAGHVVLRTLYKHAIRSLTDYATPALNTLSEWQWDKLEVTQNNAMGVIVKAPMRTKIENLHMETGLASLQTRAERLTACFATKLITRAREGDIKNGTLTSTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8S0</accession>
    <name>A0A8J5N8S0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutathione peroxidase</fullName>
            <ecNumber evidence="4">1.11.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GPx-L1</name>
        <name evidence="10" type="ORF">Hamer_G001212</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.9" evidence="4"/>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8S0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF88">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035277248" description="glutathione peroxidase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7175192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="188" mass="21325" checksum="F9F178EF08BDFBE0" modified="2022-05-25" version="1">MDRRVMPLLLLGATSLVVNPVVGKIFAARRCGDVEGDLYQFSAKTLNGSEVINFDRYRGKQEPGANATEIYNGIRHVRPGGGFETKITLFEKTDVNGQHENEIFTFLKSACTYTDTDFETRLYYEPKRVGDIHWNFEKFLVGRDGKPRVRYHPEVTDPEALKGDIGTLLYEYPPSGTLGNVHQQRGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NBU4</accession>
    <name>A0A8J5NBU4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cuticle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NBU4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="158" mass="16951" checksum="FDB3D3EC2AAC8211" modified="2022-05-25" version="1">MGVCSASTYQAYNHGHHYGVPVQPRWTGPVAATVPAGVDGKVIPVSDTYEVAAAKNAFFRAYQNQVDTIRSRRYGTPGYASVPPVAYAPVVNTFTPVVPSHSYGVPSHSYGVPHTTYNVAPGPVRDTPEVAAAKAQFFRNFERQAAAAAAAPDHYTHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NC09</accession>
    <name>A0A8J5NC09_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Delta(24)-sterol reductase-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Dhcr24-L2</name>
        <name evidence="3" type="ORF">Hamer_G008181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NC09"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7177545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="283" mass="32447" checksum="534B998D71E2BBAF" modified="2022-05-25" version="1">MQPEELFGNTGEELTNEEPASLLKEVEPDDLEQDLGPIDLEENIWTVPKTPASTQSSATPATPVSSATPATPVSSATPATPVSSATPATPVSSVTQAIPDCQNALVRRPDEATPRKKSRRRQSGMLNEIGRWFKPWFFKHVETFLKKNETGIEYIPIRDYYHRHTRSIFWEIQIYPIWLCPFKLPANPGMLHPLNDEEALFVDIGTYGVPKVEKFEPVETTRRIEKFVRKVKGFQMMYADSYMTREEYREMFDHSLYDKMRAKLGCEKAFPEVYDKVNRKARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCF9</accession>
    <name>A0A8J5NCF9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCF9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="73" mass="7664" checksum="97B80DEB3493E2F7" modified="2022-05-25" version="1">MYQVTPMSPTKVNCPPGCGAAHKGAPWGRLLWGQHVTTGDNPSPAGVEGRATPYIDGQLGMAGHMATSWEQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCK7</accession>
    <name>A0A8J5NCK7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein heavy chain 3, axonemal-like 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Dnah3-L21</name>
        <name evidence="3" type="ORF">Hamer_G028623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002891">
        <property type="protein sequence ID" value="KAG7176743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCK7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000009">
        <property type="entry name" value="Dynein heavy chain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961:SF8">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="2">
        <location>
            <begin position="144"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7176743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="272" mass="31429" checksum="08450A87DED22879" modified="2022-05-25" version="1" fragment="single">LKFFQRWADEKIPDVFWFSGLFFPYSFLTGIRQNYARKHAIPIDRIDFLFKVMEKEVEDIIQECIRPNFVELPVVIERLPTPNVQGQYYPLDTDLEDNESLPYDNDSPQLKKEGDQTVKVPTEQQEKEDNENDSQSQSHESDDVIYQVIPRQAQGGTYTWGFFLEGARWDREQHCLAEMSAKQLHDQLPIILFQPAALPDMSHHEGVSCKYEDQAEEKGMYHCPVYRTSERSGTLSTTGHSSTYILDLILPSSLPCHHWVSRAAAALTQLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCV1</accession>
    <name>A0A8J5NCV1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeobox protein HMX3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">hmx3-L</name>
        <name evidence="13" type="ORF">Hamer_G000193</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the HMX homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCV1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000053">
        <property type="entry name" value="H6 family homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051300">
        <property type="entry name" value="HMX_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110:SF3">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="148"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="150"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="59"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG7176979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="292" mass="30831" checksum="8E36FD95B7E53EC4" modified="2022-05-25" version="1">MSHMSALARHPFLSLYPELGGVTPTSPMTPLGGMGVPLAAKSPWYPPWALPPLAAFASAREKDTGSPAGGGPGSPLSEAPVEVVRSRSPSPLARSPSPPPSPPSPSSRDDHHRAGDADGVGGVGSSSGGAASTNSGGAGDDADEDRKRRKKKTRTVFSRSQVFQLESTFDMKRYLSSSERAGLAASLHLTETQVKIWFQNRRNKWKRQLAAELEAANMAHAAQRLVRVPILYHDGSTSENAHTPPAPPQPPGLPPQPTALPPYSLYYPPVSSAYATTVQAPTPVRPTLSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDG0</accession>
    <name>A0A8J5NDG0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Chst11-L5</name>
        <name evidence="10" type="ORF">Hamer_G008418</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDG0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7177747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="365" mass="42108" checksum="945949F79521C04B" modified="2022-05-25" version="1">MHGRADIKSRNTQPAVHLRLLHPHYALAPEDIPIPVSCTAECIVVSNGGVRIPSFIATKDSVWYPGRDIPPPTLSEGGDGGVGWEARQKDGGLVSKEGVILWEKQQERRQKALMEGCRGTNPISELRRVLISQPRLQRLLTDDRHRTMYCFIPKVACTNWKLLWARLTGRYNTLTQEEKTSGDIHVILDKDIQQENRKLSVLRGKLAVYTKFLIVRHPYERLLSAYKDKVAGISETNFQRKVLNHVQTIRPNATQTDIKWTEFISYIIDGGYKEDEHWSTYKKLCHVCTVHYNYIAKYETLTEDSEEILRRIGAPDDLHFPVFEPSNTATVLQTYMRNLTKEQVVGLYRVYKDDFDLFQYSPDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDK0</accession>
    <name>A0A8J5NDK0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G000487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDK0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7177221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="57" mass="5917" checksum="B8977C3CBB305AEE" modified="2022-05-25" version="1">MKSIGDHKGKEGVVWEVVWCGGLCGVGGCVIGCVSGDAVRVVCEDCCEDAVRVVCED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NIQ0</accession>
    <name>A0A8J5NIQ0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="13">GNT-I</shortName>
            <shortName evidence="13">GlcNAc-T I</shortName>
            <ecNumber evidence="13">2.4.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Pomgnt1-L3</name>
        <name evidence="15" type="ORF">Hamer_G003877</name>
        <name evidence="14" type="ORF">Hamer_G028296</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11456"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="2.4.1.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">The cofactor is mostly bound to the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.101" evidence="13"/>
    <dbReference type="EMBL" id="JAHLQT010030497">
        <property type="protein sequence ID" value="KAG7161019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAHLQT010000697">
        <property type="protein sequence ID" value="KAG7178106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NIQ0"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003827">
        <property type="term" value="F:alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047223">
        <property type="term" value="F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052463">
        <property type="entry name" value="O-linked_mannose_GnT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396:SF1">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7161019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7178106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="108" mass="12382" checksum="6CA7690B58C6BE92" modified="2022-05-25" version="1" fragment="single">IINLISSHFKSILVEVFQRYPEADKAIILEDDLDLAPDFIPYFHQTAPLLTSDPKLLCVNAYSYNAFNHTALDPTRLYRVHGLPSCGWMVRRHVAKEMVSKWAPVNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T768</accession>
    <name>A0A8J5T768_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arylsulfatase H-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ARSH-L</name>
        <name evidence="7" type="ORF">Hamer_G017869</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010216">
        <property type="protein sequence ID" value="KAG7172890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T768"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF49">
        <property type="entry name" value="SULFATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14707">
        <property type="entry name" value="Sulfatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035299218" evidence="5">
        <location>
            <begin position="23"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="6">
        <location>
            <begin position="58"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7172890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="527" mass="59593" checksum="402BD42A2101B42C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TC12</accession>
    <name>A0A8J5TC12_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PGLS-L</name>
        <name evidence="8" type="ORF">Hamer_G018619</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="JAHLQT010012106">
        <property type="protein sequence ID" value="KAG7171498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TC12"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7171498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="262" mass="28931" checksum="F5FBF69BCE355EE5" modified="2022-05-25" version="1">MVDDVNTIQINLSYSSCSSYKMSSPVSKIVRKVVKNEEEVAEELCSLIEKLSNESIKQRGSFTIGLSGGSMAKFVCNGIPSIQTEWGKWSLFFCDERLVPFTAEDSTYRLYRNGLVGKTPLKEEQFIAINPDLEVTAAAKDYEEKVRAKFPDCDWPKFDLLLLGMGPDGHTASLFPGHQLLKEDNVWIAAISDSPKPPPCRVTMTFPVINAARCCVFAMAGQGKADMVKRILGDGEELPTGMVKPVRGELIWILDEAAASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TE73</accession>
    <name>A0A8J5TE73_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G032106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007681">
        <property type="protein sequence ID" value="KAG7174151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TE73"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="145" mass="16564" checksum="A77FEFA1ABFE6398" modified="2022-05-25" version="1" fragment="single">KRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDYSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDSSSDEQEATSDDMFAIAAITVVFCDAVHQRRDAHAPASPCCTSSLGPQIEPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TH46</accession>
    <name>A0A8J5TH46_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-2-macroglobulin-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">A2m-L6</name>
        <name evidence="9" type="ORF">Hamer_G001162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF171">
        <property type="entry name" value="PREGNANCY ZONE PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17789">
        <property type="entry name" value="MG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="VWFC" evidence="8">
        <location>
            <begin position="54"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="912"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="917"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7175154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1614" mass="178248" checksum="12DE1626A11FC16F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TH98</accession>
    <name>A0A8J5TH98_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho family-interacting cell polarization regulator 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RIPOR2-L</name>
        <name evidence="4" type="ORF">Hamer_G009650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TH98"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031780">
        <property type="entry name" value="FAM65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026136">
        <property type="entry name" value="RIPOR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15829:SF13">
        <property type="entry name" value="FAM65 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15829">
        <property type="entry name" value="PROTEIN KINASE PKN/PRK1, EFFECTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15903">
        <property type="entry name" value="PL48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM65 N-terminal" evidence="3">
        <location>
            <begin position="215"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="FAM65 N-terminal" evidence="3">
        <location>
            <begin position="289"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7172292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1135" mass="124373" checksum="0B194A50E3FBE6E7" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5THD5</accession>
    <name>A0A8J5THD5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Lypla2-L</name>
        <name evidence="4" type="ORF">Hamer_G009706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5THD5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF68">
        <property type="entry name" value="PALMITOYL-PROTEIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7172337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="120" mass="13221" checksum="4877F612E20DA41F" modified="2022-05-25" version="1">MLLVMTLVSQSEGQVMPVTLNAGFRMPSWFDLKSLDVDGPEDGDGIKKARDGIHHLIEEEVKNGIPHERIMLGGFSQGGALALYSTFTHTKTLAGVVGLSCWLPLREEFPQVSTKCYFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TI39</accession>
    <name>A0A8J5TI39_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear factor 1 X-type-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NFIX-L</name>
        <name evidence="3" type="ORF">Hamer_G025639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006929">
        <property type="protein sequence ID" value="KAG7174795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TI39"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000647">
        <property type="entry name" value="CTF/NFI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020604">
        <property type="entry name" value="CTF/NFI_DNA-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019548">
        <property type="entry name" value="CTF/NFI_DNA-bd_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492">
        <property type="entry name" value="NUCLEAR FACTOR I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492:SF8">
        <property type="entry name" value="NUCLEAR FACTOR I, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10524">
        <property type="entry name" value="NfI_DNAbd_pre-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51080">
        <property type="entry name" value="CTF_NFI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTF/NF-I" evidence="2">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7174795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="126" mass="14389" checksum="FAAD894A2DBDE0FF" modified="2022-05-25" version="1">MFTVYNNNGIYLFFLSQDEFHPFIEALLPHVKSFAYTWFNLQAAKRKYFKKHEKRMSLEEERRCKDELQEDEGGISKEDEGGISKEDEGGISKEDEGGISKEDEGIINEDEGGISKGRMKEASVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TI68</accession>
    <name>A0A8J5TI68_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Epsin-1-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Epn1-L3</name>
        <name evidence="2" type="ORF">Hamer_G020120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010583">
        <property type="protein sequence ID" value="KAG7172562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TI68"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="414" mass="45354" checksum="29AE8CDDF091C0A9" modified="2022-05-25" version="1" fragment="single">DRPQSTPQDRPQNTPQDRPPKHPTGAGPRAPHRTGTQSTPQDRPQSTSQDRPQSTPQNRPQSTPQGRPQSTPQDRPQSTSQDRPHSTPQDRSQSRPQDLLRVTLHPDPQTTPPMTPQTVRQSPLAATLQNTTRTTTKSIFDSPELEGYSLRSVVHSSQRQQKSAMSEVGPHSSSPDRGCVSTSSSSLLLALRTPIYEHPQSPGHTLAPPETPALLRSLPDMRPITQNVLPRNSTRRASVSQTGSHTRRMEPCNTPYLDPCTMKSVITTPVSRVYTPNNGHSSVKIESSTTTIEPYSPTNGPCVLKSESVSPENELHTMRTPDNLGIPRTPKITPNPRFPHLTPVVPHTPKISNGMDTSRRPSARNLILESTLASISIMTEDSQEQESSAAISSCSQESIQLTRQYSLKASSGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TL52</accession>
    <name>A0A8J5TL52_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G016696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002318">
        <property type="protein sequence ID" value="KAG7177406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TL52"/>
    <dbReference type="OrthoDB" id="6350825at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="129" mass="14144" checksum="FA98A784BAE36CEA" modified="2022-05-25" version="1">MGNAVQKIRARLVMERVHAHGMPAQAVFYPERSRSPDGRKSSTGSSSEASWTSAQDDSLDAALQSFDDLHDPDGALSDLLARTGEDDFMKAVLSFCSYMDGRMDTLDNSRIYDEFRSYTACGPPKVSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TLH9</accession>
    <name>A0A8J5TLH9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Crustacean calcium-binding protein 23-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Ccb23-L1</name>
        <name evidence="5" type="ORF">Hamer_G000183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TLH9"/>
    <dbReference type="OrthoDB" id="444540at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524:SF6">
        <property type="entry name" value="CALCYPHOSINE LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7176970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="204" mass="22804" checksum="588F68E255D77373" modified="2022-05-25" version="1">MSNEANMKDAAKESLKKATDPLEKLRSHCLSQGYSGILSLGKLFRRLDKDSSWTLSKEELSRGVSQFGLDFSDADVNKLFSDFEKDGQSGINYEEFLEALRPSMTEPRKAAVEAAFKHLDKTGDGVVTVEDLKGVYSAKKHPKVVKGEATEEELLKKFLNMFESSTSVDGKVTKQEFLDYYSGLSKAIDKDEYFVSVVNMSWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TM77</accession>
    <name>A0A8J5TM77_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transient receptor potential cation channel subfamily A member 1-like 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Trpa1-L11</name>
        <name evidence="1" type="ORF">Hamer_G001180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010006108">
        <property type="protein sequence ID" value="KAG7175172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TM77"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099604">
        <property type="term" value="F:ligand-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF12">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="192" mass="22058" checksum="94301BE9808B45EF" modified="2022-05-25" version="1" fragment="single">MKWMWLKPFLDSPLKNSPDNRISPKNSMDYIKEFYCKKCSRFEVDPKYTIEDRCYCGLRKNEHEDIRDFIIPVDKGFASVDIGPSPSTSNDSSSMRSNLTWDPEIILKTCRTDAYGIVHLKNNTIGSYRPSDYVRLEDNTPMDKVLRLFSSHWSLMIPQPPKLAISIIGQCKNFGAYGTKKENFVSGLINVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5TV87</accession>
    <name>A0A8J5TV87_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xyloside xylosyltransferase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Xxylt1-L</name>
        <name evidence="2" type="ORF">Hamer_G008406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001931">
        <property type="protein sequence ID" value="KAG7177737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5TV87"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140560">
        <property type="term" value="F:xylosyl alpha-1,3-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042465">
        <property type="entry name" value="XXLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46612">
        <property type="entry name" value="XYLOSIDE XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46612:SF1">
        <property type="entry name" value="XYLOSIDE XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="386" mass="44442" checksum="7FCB390465DA979A" modified="2022-05-25" version="1">MLFRVRFLGQATILLLVVVCLILLSGWREVKPLVVVVPSPHLQPPPQPHPPSSLHLSPEDEDDSVNTEQQILPEQEVVPLDPRENDLLYRPPLEVAFIFTHARDSYPLQNKLRVAVSTLLAASSAPLRLHLITDQDGFHIASQIIRQAQETNQLDSRYVKLVYVSADDFIPEIEDSVTILQEFFTRRTNAYYRDALFFFSLHLHKLLQGLDRVILMDIDIKVKGDIAELHSHFERFSPSNVIGMTLEQSSVYRHVLSAYRKKHPNTTFGSPPTQGGFPGFNSGVVLVDINKLRKSDIIRKYLSKSKLREKTTYYSFQGHLGDQDLYTMIALDHPELFYTIPCGWNRQLCTWWRDHGYRTVFDQYFNCTEEFKILHGNCKTPIPDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J6X9</accession>
    <name>A0A8J5J6X9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G-protein coupled receptor moody-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">moody-L4</name>
        <name evidence="14" type="ORF">Hamer_G020069</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010045843">
        <property type="protein sequence ID" value="KAG7154007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J6X9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF74">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="1"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="225"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG7154007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="455" mass="50319" checksum="FF8B6F87D5DC4AD2" modified="2022-05-25" version="1">MKVHNATAVFIINLTLSDLMFGVFNLPLAASLFVHRAWVHTWFLCLLFPILRYGLVAVSVFTVLAITINRYVMIAHPRLYHRLYTRTWLAIMVVSTWIGAFGALVPTLLEFWGTFGLDPAIGSCTILPDSDGNSPKEFLFVFAFVLPCVAICVCYARIFSIVHRADKKSHSHGQRFLKVNGKRQKPVASPCADPPTLQTLHATPLHDRLQLETLVKLSTSSNSVKVEIVEPGEETQKQQKEREVDANGEGGERDKKDGTRTPSPDTTPGDVTTDASSLLKTEANGFSGHNSDEGVGVSAAACSPIRICPPSAPDSPASEKSETKITRAIERRPSTISGKGGTFSQLRGTFRRTRAGSFIARQPTLSAKDRRLLKMILVIFMSFVACYLPITLVKTFSKDDNPILNIFGLLLIYMTTCINPIIYVVMSSEYRQAYVSLLTCKRDFDPTNRSITKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5J9E6</accession>
    <name>A0A8J5J9E6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative serine threonine protein kinase-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G031996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010047121">
        <property type="protein sequence ID" value="KAG7153419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5J9E6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine-threonine/tyrosine-protein kinase catalytic" evidence="2">
        <location>
            <begin position="69"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7153419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="222" mass="24022" checksum="F9B6AB26BF9A533B" modified="2022-05-25" version="1">MDKNHIVDNKGQEAQVSLVRVTTIPRKTSSTPTSSSIPHTSSSSHNSSSSHNSSSGGRDLPQLTWDHLSLMGKVGTGRYGVSHHGQLTLDNGDVTAVVVKILHSGKDNTKEARVLHELGGTGGAPILYGVTTDPHAIVMQYCRGVTLSTILHHFSHLDLHAGNVIIDTSTSPYTCHLIDVGMSERIPPDDGWYEQTDWVALQDIQTRLHLHSPDDLGLLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JAS8</accession>
    <name>A0A8J5JAS8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Star-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">S-L10</name>
        <name evidence="3" type="ORF">Hamer_G017665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010046276">
        <property type="protein sequence ID" value="KAG7153851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JAS8"/>
    <dbReference type="OrthoDB" id="6366644at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053202">
        <property type="entry name" value="EGF_Rcpt_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009:SF2">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase FkbM" evidence="2">
        <location>
            <begin position="144"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7153851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="336" mass="38150" checksum="13E39C212D323429" modified="2022-05-25" version="1">MARACITERQQSRFLTIWLMGLTLATVVNFWSPRNNRHQGVLLEDSTQNRQSQCNTSVAAAASTATLNSMVEVLLDGPMEAEDRRLVQWVKEGGGGRVFPPSSLHYNITLENPGGWRDTIVWKFYVKVIEHYFGKKEGGFFVEAGALDGVLLSATLRLEQDLHWSGLLVEPRPDMFQELLYKHRKAHAVRFCLSEKPYPHKTSFWMSPDFVKSSVAFSAVASQLYEKVNADQRETGYVVNVHCIPLFTLLTALGRRHVDLFVLDVEGVEWGVIDLFPFDQITIDMLAVERKDKGDRDRAAFIHLVQSKGFTLAHSLKEDFIFIRNAAHLDIDPNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JCM3</accession>
    <name>A0A8J5JCM3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Orexin receptor type 1-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">HCRTR1-L3</name>
        <name evidence="7" type="ORF">Hamer_G023856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010042531">
        <property type="protein sequence ID" value="KAG7155221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JCM3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF69">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7155221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="281" mass="31882" checksum="62DB7A2DE2AD4412" modified="2022-05-25" version="1">MSYWKVRSAAGLGDLPTREDQRRTEVQRGTRQPGHTSQFVTNEYVKYFRKTKRCCRVRPRFYDGTLYETAILTEMDGRDGFLYHDAHQLPSFLTPAPMGIGGGNGGSHTPTLLGGRTPSLHQLEEAEVDVVREKRNQRYIATIVTCFALCLCPLMILRLVKNMVLETYDNSGHFDITFITFVWVAFLPTITTPALYAAWRLTRTTKERLCSYLQFGFRGRRSAHAQNFTPMFYSCHARAAHRLSLEPALAPSSPHAHHTPHHGGHTSRSDNLRPYSLALPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEA6</accession>
    <name>A0A8J5JEA6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G026522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039769">
        <property type="protein sequence ID" value="KAG7156165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEA6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7156165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="104" mass="12076" checksum="4396C9EC15AF2B0E" modified="2022-05-25" version="1">MNRTITTRGTGKNKKGKKQQRKHNKNKRKKNKKNKTDEEEIERSQGSGGGPGDSRRDALDFLTGTVIETKVMLRSLRRKVGKNQPKRNNKEGKKREEQEQEEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEL0</accession>
    <name>A0A8J5JEL0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Haloacid dehalogenase-like hydrolase domain-containing protein 2</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phospholysine phosphohistidine inorganic pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Hdhd2-L</name>
        <name evidence="15" type="ORF">Hamer_G010561</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010047199">
        <property type="protein sequence ID" value="KAG7153268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEL0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000051">
        <property type="entry name" value="Phospholysine phosphohistidine inorganic pyrophosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006355">
        <property type="entry name" value="LHPP/HDHD2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01458">
        <property type="entry name" value="HAD-SF-IIA-hyp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG7153268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="177" mass="19514" checksum="37AFBD51A557050A" modified="2022-05-25" version="1">MARKIGAVLIDLNGTLHIENTVIPGSIEALKKLRASNVKIKFVTNTTKESKRILHERLTGIGFSIDKDEIFTSLTAARQLIDKQNLQPYMLIDDAAKEDFSGISSENHNAVLVGLAPDKFNYEQMTTAFRILLEGAPLIAIHKGRYYRRGDGLALGPGPFVAALEYSADATKELQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEN1</accession>
    <name>A0A8J5JEN1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G024440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041894">
        <property type="protein sequence ID" value="KAG7155354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEN1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7155354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="301" mass="32856" checksum="F7170E449A00F7CF" modified="2022-05-25" version="1">MDVVEIVSLRCGGCGVWISLRGGVGERRREVVRGEDIMYCYQPLFRRRRVKKRPPHPHHACWPPNPTTCDNTQAPISPTLPLHSLLCFNPPPPSSNSSLLQTPSSFNLFLFDPPSFNPLLLTSSFNPSTFPSTLPPSTLSFDPPSFNPSLNPSPPQPFSPLLTPPLLQISLLRLLLLQPLLNLSLLPLFDLSSFRPSFRPSSDPPSFNPLPNLNLPSFDPPPSTLLLSTSSFNPPPPHLLLPQPSSFDPPPFDLLQPPLLFLSTLLSSTLPSSTLLLSLTSASPQPFPPSTSPPSTPPPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JEU0</accession>
    <name>A0A8J5JEU0_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Trgs1-L</name>
        <name evidence="11" type="ORF">Hamer_G019862</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041650">
        <property type="protein sequence ID" value="KAG7155444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JEU0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="10">
        <location>
            <begin position="913"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="495"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7155444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1076" mass="122065" checksum="7E9ED2D797C30D95" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHA1</accession>
    <name>A0A8J5JHA1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MED8-L</name>
        <name evidence="8" type="synonym">MED8</name>
        <name evidence="10" type="ORF">Hamer_G023225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010041254">
        <property type="protein sequence ID" value="KAG7155545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHA1"/>
    <dbReference type="OrthoDB" id="150687at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7155545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="239" mass="26735" checksum="C1999D6715B80F9A" modified="2022-05-25" version="1">MQREERALDVALDVILQRVVDIKGSLQELLVKMEREGEQVDWPSYLNSFSVISAQIYTLMKLLKNDKTPILRNFLTLPLQLNAESDEKLLLATEGRVPSFSHDFVPNMLRTKPEPDVEQRHLALEAKMAQANADTALKQINVHNKVVKHVMDLVNTAREEWETETASRTNQPQTCSVNETHALIAALGTGKGFKIRTQPPGPSPTMPQQPPPQITTTSKAVSAVKTNIKAANTIHPYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JHL3</accession>
    <name>A0A8J5JHL3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glutamate receptor ionotropic, kainate 2-like 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Grik2-L16</name>
        <name evidence="12" type="ORF">Hamer_G021840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010035368">
        <property type="protein sequence ID" value="KAG7158387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JHL3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035147949" evidence="10">
        <location>
            <begin position="18"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="11">
        <location>
            <begin position="127"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7158387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="398" mass="43740" checksum="2B8EA36AA0AD4E38" modified="2022-05-25" version="1">MGLVLLVALTLVQVTLCTPSGTDGEQVRGNLVSRVSTRGTEARGLASIEAEVKPARMNENEDNRAVITIAAETEVDMALGPFAISYPRTKVAEFPAAIFVLPHRVYLPRPRGFPDVSDFVRLYHPLVWTMVFVCAGVVTVALWLAAKTESSRQNTHPSTLFLVLLHVWGALMLESMRWSERGVSRWLMGLWSLMTLVLMSTYSGALVATLTVPRVAIPIKSVEQLVSQDDIPWRLEQGGIILHTFKVVKPELDHLRPLCVTSWAQTADVKMYKKLLKGSEGLFPDCYASRTEIAQGEFAGLCDVLAGDMMVAKSFSVSGRLRQLQERGWVKQLVKSLVNNGTVCSLPPGQEEGQLPPTPLSVQQMWGVFAILAAGVGGAALVFLLEVVWCKTFLTHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIC5</accession>
    <name>A0A8J5JIC5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Actin-5-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Act5-L2</name>
        <name evidence="12" type="ORF">Hamer_G006710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039062">
        <property type="protein sequence ID" value="KAG7156716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIC5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0558">Oxidation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7156716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="379" mass="42087" checksum="6FDB184BB4AB93F5" modified="2022-05-25" version="1" fragment="single">ELNMCDEDASALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEESPVLLTEAPLNPKANREKMTQIMFETFSCPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAIMRLDLAGRDLTDYLMKIMTERGYSFTTTAEREIVRDIKEKLCYVALDFENEMAQAAASTSLDKSYELPDGQVITIGNERFRAPEAMFQPSFLGMESCGVHETVYHSIMKCDVDIRKDLYANNVMSGGTTMYPGIADRMQKEITNLAPSTIKIKIIAPPERKYSVWIGGSILASLSTFQAMWITKEEYDESGPGIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JIG8</accession>
    <name>A0A8J5JIG8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JIG8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="713" mass="74569" checksum="5354EE876EEE4D3E" modified="2022-05-25" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JK07</accession>
    <name>A0A8J5JK07_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TBC1 domain family member 22B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TBC1D22B-L</name>
        <name evidence="6" type="ORF">Hamer_G017404</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May act as a GTPase-activating protein for Rab family protein(s).</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031743">
        <property type="protein sequence ID" value="KAG7159962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JK07"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071889">
        <property type="term" value="F:14-3-3 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000009">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000004">
        <property type="entry name" value="TBC1 domain family, member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="208"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7159962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="508" mass="58584" checksum="5CC568C49A3987D6" modified="2022-05-25" version="1">MQSLDPQNGKNFWKKNSKSVPGSMRAVYGAMHPPITRSPNDYHLTRRPREGPPHPLTGGQQIMSSPRKESTQKKPEPSDSFQDYQESVNDAWDCGDDEFCVISDVKISNRMVQSAALSVINSHRSGQMPTSNLAELHQQIQPSIAPTEAPAVEVTTYPPVNNIHSSAGVLPCMPASNERDMVKQEKFLELISSNSTNLMELRKLSWSGIAPPVRAVTWRLLNGYLPANAERREDTLKRKREEYWSFVKQYYDTRHEDIYQDTFRQIHIDIPRMSPLVPLFQQTIVQEMFERILYIWAIRHPASGYVQGINDLVTPFFIVFLHEVVPREEKLDTYDVELIAEEDRAVVEADSFWCMSKLLDGIQDNYTFAQPGIQTKVQQLGELMKRIDVSLHQHLERHEIDYLQFSFRWFNNLLMREMPLGCTVRLWDTLHAEPDGFSHFVLYVCAAFLKYFSQHLMAQRDFQGLMLLLQNLPTSSWSDSEISLLVAEAFRLKYMFADAPNHLQASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JLH4</accession>
    <name>A0A8J5JLH4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamate receptor ionotropic, delta-2-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Grid2-L3</name>
        <name evidence="11" type="ORF">Hamer_G001824</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031306">
        <property type="protein sequence ID" value="KAG7160542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JLH4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="73"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7160542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="376" mass="41358" checksum="0BF0BA32D603D37A" modified="2022-05-25" version="1">MISGGPQEEKYMPHIIVTPGPNSVVTGSLLEILSIVSQHLGICVRYQESADKAGGVRLPNGSWTGVMAMLTTGVWLMILMTLLGVTASTCVLRHGNERRFRQVRFRGSPGPEKGRDVRVPGLATFTGESVIWTAPGGVVRLLMGLWMILSLTLMTVYRSNLKAMLIMPRVTIPFDSLQDLVTTDLPVWQAEPNTDLGRLNSMFNSVHGHSNVTWGVNGFVTGKHVLAAPRTALLEIIHSAFSKIIFEIQMGMCSTYLMSESFLRTTIGLIYPKGSTLRPKIDPLIVRLREGGILDYIYHQAVINSSKCLKPLSSIPDTSRALDLGDFYGVFVYGGGMMLGCVAFLLELLLAPFRNEVRQETSSRFPSSSSPRRTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JQ27</accession>
    <name>A0A8J5JQ27_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TWiK family of potassium channels protein 7-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">twk-7-L1</name>
        <name evidence="7" type="ORF">Hamer_G011397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JQ27"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF291">
        <property type="entry name" value="IP11374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="615"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7158728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="785" mass="83950" checksum="0516CB52458093A8" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRH7</accession>
    <name>A0A8J5JRH7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030867">
        <property type="protein sequence ID" value="KAG7160743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRH7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7160743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="93" mass="9743" checksum="FE753D60733C7DDE" modified="2022-05-25" version="1" fragment="single">KVDALVAAVVVAVVVAAAVVVEEWMAVELLCVLETGSANSASSITSLHVISASSALPQNDVRCSPPSREHPGPRRRTCYGGSGNTTRDIYFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRK3</accession>
    <name>A0A8J5JRK3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Diphthamide biosynthesis protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Diphtheria toxin resistance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dph2-L</name>
        <name evidence="12" type="ORF">Hamer_G001978</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026502">
        <property type="protein sequence ID" value="KAG7162947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRK3"/>
    <dbReference type="OrthoDB" id="361972at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7162947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="527" mass="57441" checksum="1508BE523A839013" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JRP4</accession>
    <name>A0A8J5JRP4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Steryl-sulfatase-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">STS-L3</name>
        <name evidence="4" type="ORF">Hamer_G022522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010032848">
        <property type="protein sequence ID" value="KAG7159688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JRP4"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF49">
        <property type="entry name" value="SULFATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="3">
        <location>
            <begin position="97"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7159688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="364" mass="40737" checksum="A7C14263342AC68B" modified="2022-05-25" version="1">MQEMGSPHPFFTLPPDNTVYQMLVTIMLVTGVTLWGCKGQRGVVFVLLPFALFIYGSRFHTTASTDRWWLASPWMMRIMNSILMDDERVLEQPMVLAGLSQRLVDHSVKFIAHHAQDDRPFFLYHSFTHVHIPMFTAANMSGRSKHGRYGDNVEEMDDGVGRILNALTEHGLDQHTLIYFTSDHGGHLEARENGERVGGYNGRFKGGKCAGGTEGGIRVPGIYRWSGHIPAGVTDDTPISMLDLLPTTLHLTGLPPLSQLMPHLPQRELDGVSIGDLMTSRKQLPPRVLLHHCKGEIHALRIVQGNATYKMQLAGYKFKPGSTQCGWGLKTCCSCYDVINYSHEPTFQPPAGPLRRSPDSYQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JS94</accession>
    <name>A0A8J5JS94_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G012612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010031643">
        <property type="protein sequence ID" value="KAG7160079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JS94"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="103" mass="11889" checksum="077015D6603187AD" modified="2022-05-25" version="1">MQTWLDIVKAAIKASQHQLTTLIGEDTDLLILLLYYAEANNRGLYFRSDKSTVPKVYNLSEMKQVLGSDMCSQLLFIHAFTGCDKFPHFQCWQKISVPEICEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSB1</accession>
    <name>A0A8J5JSB1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative CUB domain-containing protein-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Cdcp-L12</name>
        <name evidence="5" type="ORF">Hamer_G007632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSB1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035159750" evidence="3">
        <location>
            <begin position="17"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="33"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7160870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="170" mass="18641" checksum="1E1694DAEC9496A7" modified="2022-05-25" version="1">MVTLALVLMVITGVAADSFQLPAQARALVTEPCGVINMAPGERKAIQDDSNPKANYSPNQRCQWTFKCAPESSTYLEFRCPYFSLEESTSCVNDRLILKSRTNRETCEVLTDEESSKSVTARVVVSRVNIAVKASVSSELVTASNISILRVEFKDSENWVSSLKTPVGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSC0</accession>
    <name>A0A8J5JSC0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSC0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="9415" checksum="B03D3110D795A5CD" modified="2022-05-25" version="1">MSIGVWAEGVCAAGGRDGWGDVWGRAVTSPALFCNMIRRRGLYRQWGLMCSPERLPPHVELSGMAVSALDELRRICINPEKKNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSL4</accession>
    <name>A0A8J5JSL4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB/POZ domain-containing protein 6-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Btbd6a-L</name>
        <name evidence="3" type="ORF">Hamer_G002782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSL4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="79"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7163577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="559" mass="61984" checksum="D6DC90211DA79CCB" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JSN6</accession>
    <name>A0A8J5JSN6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aster-B-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Gramd1b-L1</name>
        <name evidence="7" type="ORF">Hamer_G002692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JSN6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="6">
        <location>
            <begin position="135"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="376"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7163501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="441" mass="50277" checksum="ABB74EC877AE508F" modified="2022-05-25" version="1">MSDLDWYRTHTIRRPTPHSVPLQHLTITHDSLPGYTKKYVVITLTKSFRQAQYCTSRREDRSASYIATGERRGESPNPRPSSSQMPVASSVHANIYTSRERLQRLDNSSESDDTTARNGVGEARSWRCPGEEQHQGKEAINVVIALPVDTVFDLLFVQEQFMLDIYSVRKTYDIVIPPWQDMEEGQKSRQLTFTMTLPSSNLVASKVSYVTEKQVIQSQTQPGLVYVVETETVNSGIPYADAFYIATHYCIMKEDEIKTRLVTWVCIKYKKTIWGFLKGPTPPPPEHSRNCSWAVVMVLTALVALGMGNLILFARVRWLEHHSILGSPLYSTPATKYLSVTGSWEAVARILQRQEGLHVNQMNHWKAKLRESSHTLQQVQQSLETLLKTIPEHEELLKLALLQESADVETGWLEAEARLEQQLQDLEGRHTQSQNTLEDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JT36</accession>
    <name>A0A8J5JT36_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cation transport regulator-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Chac2-L1</name>
        <name evidence="5" type="ORF">Hamer_G002901</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010026447">
        <property type="protein sequence ID" value="KAG7163677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JT36"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7163677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="137" mass="15555" checksum="3D7542F397F11A85" modified="2022-05-25" version="1">MLQAQVWGVAYEIPPEQEMSVTKQLNVREQRFNKRKSVTMYCPSGELLSHPVLVYVGSNEPELFLGDATLENMAEQIARSHGPSGANSEYLFQLARFMRAEVPQAHDDHLFQLEAAVKELLTKSSEDHPQIDCRHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JTK5</accession>
    <name>A0A8J5JTK5_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mucin-2-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MUC2-L1</name>
        <name evidence="5" type="ORF">Hamer_G014102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028947">
        <property type="protein sequence ID" value="KAG7161545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JTK5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035325145" evidence="3">
        <location>
            <begin position="30"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="4">
        <location>
            <begin position="156"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7161545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="433" mass="49550" checksum="045270776FE0BCF0" modified="2022-05-25" version="1">MLSTSRGAEVPYLLLVLACLLVHIHGFTAGQSLETDPRAEKQTVTSETAGLVRIPNPDEDCDDEEPEVHGTCSCCYGNEFYTHGSVVHTDAKKCLQLVCHDGEIVSKYTGYHSYCSCCEYKGQLYNHATYLPIPCGYMRCLSGRWYVYDTIDKCCGHCIAYDDVHMVTFDNRYYDFHGHLNYSLAQSDTSYSPEVGVFADFKPCSFNGLVSCLDKIQVNGECYTFPTSMPYRYAYPLEVNGVTYPIIVVKTSYNCIKYIGLTSRITLIVCPHRVDVVAHPSHSDGLDGLCGHYNNYQNDDFTSRSLTVYPLYKYPLDFPLSWLTNDQCGEDYQSDCPEPHLGCSGAYTTSPCKADKGQMYSYYVRCYKYLYNYVYRISDLRHYLYSCEFDLCMLYQNGQGSYVTTWLIKLRTNALFSRWLYYNTKERRPEVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JUI1</accession>
    <name>A0A8J5JUI1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JUI1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="100" mass="11475" checksum="0D81234BFE5A2FFE" modified="2022-05-25" version="1">MHAVYEASEQQEVQQERIQVHHGNYVANGVAVAKKFLAWFIAEHNLPFTAADRLVNLMKRMFPDSVIAQGMNRKRTKCTEVMRTLGRCVTEDLLDKLSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JVD6</accession>
    <name>A0A8J5JVD6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">97 kDa heat shock protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HSP110-L</name>
        <name evidence="6" type="ORF">Hamer_G007363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010028808">
        <property type="protein sequence ID" value="KAG7161728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JVD6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10228">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000495">
        <property type="entry name" value="Heat shock protein 4b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="477"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7161728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="765" mass="85587" checksum="6600C09F536441A7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWC8</accession>
    <name>A0A8J5JWC8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G004834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWC8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="8026" checksum="5BDC9EFC87740AB1" modified="2022-05-25" version="1">MVERCGGRAGLARPTPPLPRRSPPHFVPTWFCWCGESHIHWYSYSSSSAHNTHKTGRSRELGEPHKATGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JWP6</accession>
    <name>A0A8J5JWP6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PDZ domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023937">
        <property type="protein sequence ID" value="KAG7165690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JWP6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="35"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="91" mass="9965" checksum="9F0FD3270375AF40" modified="2022-05-25" version="1">MTTTAFSHEPGTAMECLSIPITLEKEAGLDEHGRQVHDGSAAARAGLRVHDKILQCNGYDFTMVTHKKAVDYIKKHPVLNLLVARKGVTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JXR9</accession>
    <name>A0A8J5JXR9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G005524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022531">
        <property type="protein sequence ID" value="KAG7166425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JXR9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="203" mass="23665" checksum="F8569451D0DF487D" modified="2022-05-25" version="1">MYVRFWLEAPMAVRAPFNDLQLMKVLKEYPHEKVAHAAQAAISRHLWYLSEHLIGLSLFDDRIDTETKKNMVQNFQCPKKQDFSRRIVLSDETPINNVASFVTERTLDIFDVLTLDGKERAQLFLSKDPKTWKDDEVFITMRDRAINMKVVNDSAERAIALIERYNESITQNEDQKQYLLQVVATHRKKLPTASKAAMMKGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYK6</accession>
    <name>A0A8J5JYK6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRELI domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Prelid2-L</name>
        <name evidence="2" type="ORF">Hamer_G003578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025476">
        <property type="protein sequence ID" value="KAG7164388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYK6"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="184" mass="21383" checksum="FDE4D444A2586E76" modified="2022-05-25" version="1">MTVTVKAEHVYQEPVEVVAVTHLSKYPNEYDPNILSCAVLERKIDGDGQTYTKRVAAVRNVLPSIFRRVKSLQVDHFELQEESWYDRRLRKLSVRSHNISVSDWITMREASVYTPHQQNPNWTNFEQEGTITVHGLGRLGCLIEMFGKRFLSVGAQRSITITEKLMAERSKRITSFWYSEFLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JYS1</accession>
    <name>A0A8J5JYS1_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyrokinin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G005438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrokinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021845">
        <property type="protein sequence ID" value="KAG7167102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JYS1"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001484">
        <property type="entry name" value="Pyrokinin_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00539">
        <property type="entry name" value="PYROKININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0027">Amidation</keyword>
    <keyword evidence="3" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="377"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7167102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="416" mass="47190" checksum="CFB5FFA444538A97" modified="2022-05-25" version="1">MRGDTCSLFLTEQVQYFPNYRDNKKSVNTTGLEDEWAGLPQASFAQYPPALDDTSEAQPLSLLYNMYPSVTSADTVPPKSQELQYNSQDTPKRLYYSQRPGKRSVDLYDDEATETSQKQEDDHTKRNKRSVENSQEDPERRMKRQTPQHDNEPTDDNDDSTHRWWWPFVAVRRSLFSPRLGKRGDDITNEELAYDDNLATSEYLRDDNNDYLPEELTEDVTEMSSPEMLSESAAALVGKNSVSFIPRLGKRGDGFAFSPRLGKRGADFAFSPRLGRRSEFVFSSRPGKKSDFAFSPRLGKKADFAFSPRLGKRADFAFSPRLGKKADFAFSPRLGKRADFAFSPRLGKKADFAFSPRLGKRADFAFSPRLGKKADFAFSPRLGKRDSEDSSVESRNTKTQASIPRPGRAYFSPRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZ31</accession>
    <name>A0A8J5JZ31_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G029287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025315">
        <property type="protein sequence ID" value="KAG7164538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZ31"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7164538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="128" mass="14689" checksum="48104B2EDF7B97F9" modified="2022-05-25" version="1" fragment="single">RDPTLCWRRILPFSVVESYRILGQNPTVFWSGLLSYSEAESYRLLAQNPTVFWPESYPILGRNPTLFWGGIMLYSEAESYRLLGQNPTVLWAESYPILGRNPTLFWGGILAYSGVESSRLLERIPTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5JZT6</accession>
    <name>A0A8J5JZT6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DDB1- and CUL4-associated factor 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Dcaf8-L</name>
        <name evidence="5" type="ORF">Hamer_G005114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024959">
        <property type="protein sequence ID" value="KAG7164714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5JZT6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF21">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="295"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7164714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="819" mass="91733" checksum="92C3D3B9B2B0C8FE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0A2</accession>
    <name>A0A8J5K0A2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sex peptide receptor-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SPR-L5</name>
        <name evidence="8" type="ORF">Hamer_G027717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023620">
        <property type="protein sequence ID" value="KAG7165791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0A2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF4">
        <property type="entry name" value="AT19640P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="81"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7165791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="409" mass="45542" checksum="F7853936B0A5C763" modified="2022-05-25" version="1">MKLVPRMEKVMEAAGAPPHTAGPLTIIIPLLANLTATADLDYDWDYHNVTANTTTQDSFNSSTAAVHGCMSLVVCVFGSVANVINMVVLTRRSMVSPTNAILTGLAVTDLLVMVEYIPYTMHQYVWQGRSLASQYSWGWAVFVLFHAHFTHVFHTISIWLTVTLAVWRYIAIAFPQNNTTWCSMQRTHTVIVAAFFCSVICNIPSYLNFTISQAEHEGQTLYIVGFSHLALAHGGFLKSINFWIYAVMLKLLPCSALTGLSFALIQELLRAGRRRAQLMKRNSSGRAADAERQADRVTIMLLAILVLFLASEVPQGILGFLTVIPDSGFFPCYQKLGEIMDMLVLFNSAINFLLYCAMSKQFRDTFSELFKSCCVQWLAIRAPRLPPCWKAVPADAPPIEVNNTCITHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0C6</accession>
    <name>A0A8J5K0C6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Laccase-1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Lac1-L1</name>
        <name evidence="9" type="ORF">Hamer_G010207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021257">
        <property type="protein sequence ID" value="KAG7167805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0C6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13858">
        <property type="entry name" value="CuRO_1_tcLCC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13884">
        <property type="entry name" value="CuRO_2_tcLCC_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="162"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="294"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="510"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7167805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="675" mass="73751" checksum="00100134CB12F269" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0H9</accession>
    <name>A0A8J5K0H9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed RNA polymerase II subunit RPB1-like 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Polr2a-L19</name>
        <name evidence="3" type="ORF">Hamer_G012846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021643">
        <property type="protein sequence ID" value="KAG7167397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0H9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7167397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="225" mass="24424" checksum="9704322EF82ED81A" modified="2022-05-25" version="1" fragment="single">MSRSSDHKLIPHPDSQAPSAPPVGEYLQQATSEKNPINPPYPEPPPPYSLQAPTYNQPAPTYNQPAPAYNQPAPTYNQPAPAYNQPAPTCNQPAPTCNQPAPVSMAGMYGQPSPAQAVGAYPQQAPATTVVIAQQPMVPVNTQPTPVILVGTQALPPGTCKRQDKEESIMLYVGVLHFALALFYYSRNHCIFLLCSKAQVYSLWLLPIILLMMIKVDVSHMGKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K0R0</accession>
    <name>A0A8J5K0R0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G026409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023053">
        <property type="protein sequence ID" value="KAG7166061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K0R0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7166061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="385" mass="41257" checksum="885F026BF53F50FD" modified="2022-05-25" version="1" fragment="single">ASKVKLFNAVSSQLLGDSVDVSLREDHGEASQINVVQSRSVTDELRLLESQIKLKEAEAIARRVGIRQEKAEAKAKEAEAIAKEVGIRGAGRVRHLIGRPNFLHTLVVTVGSQVTRQRLQLNTGKPAMIVTEETNTFPVGVMADLSKADSMPIGLVFTKGEVRESAVSVLASRDFDSFQESFVKDPDVGTFRHFLSQGTVEVDGVETPVTILRDSGCLQTLIKESVVAARKTDKYVVLGSLWGQGIANVACVHELPVAGVDLILGNDLAGCQMGNVTPPPVLQEKPESTAELLQLEDDMPGVSPLCAVTRSMSMTNDDNVTPVVDDSLSLEGLFANPIASQDISSAVNAATGRVALIAAQEQDDSLRLLFDSANDSGHTTKYLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1I5</accession>
    <name>A0A8J5K1I5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pol-L9</name>
        <name evidence="4" type="ORF">Hamer_G027514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAHLQT010023389">
        <property type="protein sequence ID" value="KAG7165828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1I5"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="55"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7165828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="473" mass="53403" checksum="2C5CCE01639181A0" modified="2022-05-25" version="1" fragment="single">KEVLVKIRVPSILKACRDNPATGGHFGREKTFRKISQRYYWEGMKNDVQEYVKSLNPIPVPAKIWSLVGIDIIGPLQETTSGNKYIVAITDHFSKWSEAAAIPDKSAKSVAQFLYSVVCRLGCMDSLISDQGREFVNKVIDLLMDRFQTDHRIASAYHPQPNGQRERDNRTLKAALGKLVNDQADVWDQYIPGILFAYHTSIHASTKCTPFKVMYARTAKLPIDLKSADESDAAPLPDSASPDVQQTLHIIRKDLCSAVSSNIASAQSRQKENYDRHHESNKEIITGSIVYIKNCRRIHRMGSKLEPRWTGPYTVVESLSKGRIKLENVKTDKILSNTYHASNLKIYTDATSTSDVPHDLEHSTIPDRPCDTIEDKPQQPKRPRRELDETSDTTEYVSKKPKSTSMFSPLSSNARKNLAVALCLTSTKSIYFGRPSELSQPRRTCKTKGDGNCYRIRGKPWHHPRSSRAAHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K1Y4</accession>
    <name>A0A8J5K1Y4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G019422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024443">
        <property type="protein sequence ID" value="KAG7165235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K1Y4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035249655" evidence="1">
        <location>
            <begin position="27"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7165235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="242" mass="27032" checksum="00158F1BEED33616" modified="2022-05-25" version="1">MTYKVLRWTAARVVMVAVAASATVNSTFPHDITSRCLLQKVTLNTREPIRCALHCQNTPGCSLYCLQDLVCTLYNAMVTQAWNGKTLLTGIPFQRCFASSHDPRDIALSIANSSSSSTFNSDRNSQQMYNGYTCFFVDYCFMTINTVEPYWKGDLGVPYQVSTIKILTRQDANTKHFFQDVTVRLGNSSDYFSNPIFAFYAGPAPLKALVTLVSPSPAFGRYLLIQSGVSDFFCMCSIQIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K3D2</accession>
    <name>A0A8J5K3D2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025553">
        <property type="protein sequence ID" value="KAG7164154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K3D2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7164154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="208" mass="23165" checksum="B9D359779C3C8F46" modified="2022-05-25" version="1">MIIDEDVQHIIMLARQVGGEGFDDLQEEEVQEELLGHALEELSEEELVKEQQRHEDEDEEEEGEVDEVPALTVTGINKGLLLCRGTMDYFFDIDPSIERSVNFNRAIKQVPTFYKELLKELKRQVAQPPISMFFLPPSTPSPTPSTPARKPQPPVHAPPPPDSDSDMDNPPPAAPSSDLLLSSASSEAEEENFIFILANPGQLFLTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K407</accession>
    <name>A0A8J5K407_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large subunit GTPase 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Ns3-L</name>
        <name evidence="9" type="ORF">Hamer_G011020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010022636">
        <property type="protein sequence ID" value="KAG7166198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K407"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="8">
        <location>
            <begin position="161"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="245"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7166198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="617" mass="70465" checksum="ED0DB3C25102B710" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K4M2</accession>
    <name>A0A8J5K4M2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Insect cuticle protein domain-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Hamer_G024005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013974">
        <property type="protein sequence ID" value="KAG7170537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K4M2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035307724" evidence="4">
        <location>
            <begin position="16"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7170537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="97" mass="10676" checksum="FE75EAB04C4F9A97" modified="2022-05-25" version="1">MTVLVLLGLAALVAARPDNVFDLDDLHHDQDIDDDNTYTGTYRFMTPEGVEYFVRYVADDDGFRVLESNAVPASDAGVKADGNQGSFTSSEELDDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K557</accession>
    <name>A0A8J5K557_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Trx-2-L</name>
        <name evidence="7" type="ORF">Hamer_G004928</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024847">
        <property type="protein sequence ID" value="KAG7165144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K557"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000104">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG7165144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="105" mass="11959" checksum="3EDF57661515B68C" modified="2022-05-25" version="1">MVHKVEDKADFDKQLADAGAKLVIVDFYATWCGPCKVIAPKLEVMSEEMTDVVFLKVDVDDCEEVAMEYQISCMPTFVFIKSGEKVDSFSGASEERIREYLTKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K574</accession>
    <name>A0A8J5K574_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell wall integrity transcriptional regulator CAS5-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Cas5-L5</name>
        <name evidence="4" type="ORF">Hamer_G027702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010016132">
        <property type="protein sequence ID" value="KAG7169527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K574"/>
    <dbReference type="OrthoDB" id="6382929at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF28">
        <property type="entry name" value="ZINC FINGER PROTEIN 37-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7169527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="401" mass="43115" checksum="6BF78D63BABA4550" modified="2022-05-25" version="1">MSEVELVNETVSWWRIFGNKPKKFLQDHEGEESCTKSDLLLASSQELVKHFFQDIIFCDDSPVSPTKYSQAVHVVDGTVAANSLLQTTKEIVGGFPDYGVGGHQHSTRSPPVHSSTRPAGHMSAESDNNLGGYNAITASIYSTSQPGHPDPSNAQGYTMGQVGHLEPSNSSTVGGESLLASSWKFLKCSQEDFNPQTFAAVLDSTLAANSPSQTSKENVSGFPDYGAGGYQPSTTGPPVHSSNSHMSAEYNINRSGCDASLTASVCTVSHASQPDSSNTSFPLPPSSRQPTLPPLYILPSTTSTSGNYFIMQMTDGSQACQMVPMSLAHSQLNRPPASQTFNPKFKSICPECGITATTKGHLKRHLKCHGSNKRYKCQMCSCAFSRADYLKRHVAAAHPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6E9</accession>
    <name>A0A8J5K6E9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional enhancer factor TEF-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TEAD1-L</name>
        <name evidence="9" type="ORF">Hamer_G023361</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021101">
        <property type="protein sequence ID" value="KAG7167905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6E9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.80:FF:000001">
        <property type="entry name" value="Transcriptional enhancer factor TEF-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016361">
        <property type="entry name" value="TEF_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041086">
        <property type="entry name" value="YBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17725">
        <property type="entry name" value="YBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002603">
        <property type="entry name" value="TEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00554">
        <property type="entry name" value="TEA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7167905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="360" mass="40480" checksum="123E2DF2A3290B50" modified="2022-05-25" version="1">MRGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKLKDAATKEKALHTMSSMSSAQIVSATAMHSKTSLGLPPPPVSYASAFWQGGLQAGTSQDVKPFAQSPFGMGGETKPPVGGMGGLLQPAAAPSVTVPAWEGRSIATQKLRLVEFSAFMESQRDPDTYQKHLFVHIGGPATYADPILEAVDIRQIYDKFPEKKGGLKELYDKGPQNAFFLVKFWADLNVNIQDESGTFYGVTSQYESPENMTITCSTKVCSFGKQVVEKVETEYARFENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCVAYVFEVSTSEHGAQHHIYRLVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K6X2</accession>
    <name>A0A8J5K6X2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G031355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010020663">
        <property type="protein sequence ID" value="KAG7168100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K6X2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="251" mass="28733" checksum="A951F0D9BF5BD27F" modified="2022-05-25" version="1" fragment="single">MIVPLLHQWTKANALFKPPVINQCRTIELKPTKLWHKAVETSLGKGNLARKNEFLHTLDTLFDILTCKCSIQLCSESNCSHSGKRENNSHIDCGCPREKKIPVLELEFIKAQRTKAEGQGSMQMGSIDCSETKKQIANAKKREQIREREQKKKMKSEEAIQREEELCQDVYHFFDIPPISVNATKLSELVDLSLEVLEPPLTTSLTSQELRNLKETPMQVPKWPSHTQSVERCVKMVTEAAGHVYSHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K9J2</accession>
    <name>A0A8J5K9J2_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G013239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015640">
        <property type="protein sequence ID" value="KAG7169631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K9J2"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7169631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="71" mass="7942" checksum="79EDCC16928EA197" modified="2022-05-25" version="1">MRTINTICACVEYYAVCRVGLANATPYAATIIEAVSQTWHGQRRVRAGHPGPLFGALVHEWQWITLTKTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5K9Z9</accession>
    <name>A0A8J5K9Z9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase F-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Ppif-L3</name>
        <name evidence="8" type="ORF">Hamer_G011536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5K9Z9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051435">
        <property type="entry name" value="RING_finger_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791:SF6">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="63"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="398"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="150"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7168865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="553" mass="61828" checksum="929377A80E14EB52" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KBW9</accession>
    <name>A0A8J5KBW9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vascular non-inflammatory molecule 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">VNN2-L</name>
        <name evidence="5" type="ORF">Hamer_G012411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KBW9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040154">
        <property type="entry name" value="Biotinidase/VNN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043957">
        <property type="entry name" value="Vanin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609:SF14">
        <property type="entry name" value="BIOTINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609">
        <property type="entry name" value="BIOTINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19018">
        <property type="entry name" value="Vanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7170163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="508" mass="55910" checksum="9B4B3EEBD6946083" modified="2022-05-25" version="1" fragment="single">VVAGAGVKYTGAVLEYEPYDEWGEEGGLGIVRENSRVLAEYVNLAKTQGADIFVAPEYGVTSIKLHQVKGDDLFSLMHYVPDPGFLFAPCILEVDSSNIEAIRTLSCAALENQIYVIVDMGEASPCNIDTASKNPFGNAIDNSYDCPESGYIFYNTQVVFNRNGTVIARYHKKNLFLEPEFMPGTEPDEQAVFTTDFGVTFTLQVCFDIAFLHPGVTNIETHGIKDVVMSTSWVDILPFIIAPSVQNGWSRGLGVNLLVSGYHLPELSKLGSGIYRGFSNMAHDYVYDPESGNKLIVSEVESVASVSGKSPSTPRKSGKTSLSPKGNNSIRVRGSAEGSIKLGRDHLFLYDDLSEFSREILVHGESSEPHQAEVCHQDGLCCSLSYTSTSSLNYTFMAYSGILVEGFGVYKVYAQICSVVWCQTEDISTCARVDDQLPENDEFGPFTITGNFSVGHVYPMFLTRNLTLVQNDLYSIDGNGYTLTMSTEVPTQSLMTTGFYARWYQRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KDJ5</accession>
    <name>A0A8J5KDJ5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylation factor-like protein 6-interacting protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">arl6ip4-L</name>
        <name evidence="9" type="ORF">Hamer_G013373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ARL6IP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010015640">
        <property type="protein sequence ID" value="KAG7169738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KDJ5"/>
    <dbReference type="OrthoDB" id="48562at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019532">
        <property type="entry name" value="Nucl_RNA-splicing_assoc_SR-25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10500">
        <property type="entry name" value="SR-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7169738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="295" mass="32633" checksum="0BC88D30A3927877" modified="2022-05-25" version="1">MEKDPISCSDEATVQARSRPKNKKRRASTSSSSSSSASPNHREVKKKRKRTKSASSRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSDSSGSDTEVYNGKLKGKALKKALKKRKKREKALKKKLKKCKKQAKEQQKKSIKKKVKRLRKKLKKLKKDRKKETKRLKKKTVTKEKQKAEVVNHTKSDSNKEKNPKSSKNKTDVTENGSTSVGPSVDMMTTSRATTPMTREEWEKQESVTRVVYDQESGRHRLIKGSGEVVEECVSRDRHRAINKAATQGDGEFFQATIKSRASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KEL9</accession>
    <name>A0A8J5KEL9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Broad-complex core protein-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">br-L4</name>
        <name evidence="3" type="ORF">Hamer_G012312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010014894">
        <property type="protein sequence ID" value="KAG7170083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KEL9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008598">
        <property type="entry name" value="Di19_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05605">
        <property type="entry name" value="zf-Di19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7170083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="80" mass="9302" checksum="33D1998DD27B63E0" modified="2022-05-25" version="1">MYRLFGDGMGASPMAGGRSRFECPVCCKVLSTSHGLRRHINDRHTVHLTSYRCYVCHKEYRTPNSLQNHIYVYHKREGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KF17</accession>
    <name>A0A8J5KF17_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase chain 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH dehydrogenase subunit 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ND3-L11</name>
        <name evidence="11" type="ORF">Hamer_G031402</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013174">
        <property type="protein sequence ID" value="KAG7171026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KF17"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="entry name" value="NADH:ubiquinone/plastoquinone oxidoreductase, chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7171026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="195" mass="22405" checksum="5FE72A63CA3C7A0E" modified="2022-05-25" version="1" fragment="single">TPCNNSTLALPFVTHFTYLLNQPYPTHACPYSSSRDARASGIPFIVLVHRLFFFLDFSVISNVGSNPSFNTRIYAAAIIQSYVFAVLRTLYARDGYIFCFKLSEYIGSFYNCRLCLWIYFFVATGFHGLHVKLYPFASILSKAYYRSRKNSPFECGFDPKGSARLPLFFTFFNCSIFLIFDVEITLLLPLLQLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KG11</accession>
    <name>A0A8J5KG11_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replicase polyprotein 1a-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">1a-L2</name>
        <name evidence="2" type="ORF">Hamer_G028421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012227">
        <property type="protein sequence ID" value="KAG7171401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KG11"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="231" mass="25309" checksum="660275F6B7C38A6E" modified="2022-05-25" version="1">MEVVSDGDTSQEVVTDSDAPQEVVTDSDTPQEVITDCGTPMEVITDSDTPLEVVTDSNTPQEVVTDSNTPQEVVTDNDTPLEIVTEEDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPSEVITDEDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDTPLDVVTEEDTPLEVVTEEDTPLEVVTEEDTPLEVVTEEDASPGGSPKRTLPWRWSPKGTLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KGN6</accession>
    <name>A0A8J5KGN6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450 2U1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Cyp2u1-L</name>
        <name evidence="16" type="ORF">Hamer_G011658</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010018664">
        <property type="protein sequence ID" value="KAG7168969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5KGN6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF403">
        <property type="entry name" value="CYTOCHROME P450 306A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035180256" evidence="15">
        <location>
            <begin position="18"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="670"/>
            <end position="692"/>
        </location>
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            <end position="718"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="730"/>
            <end position="748"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="754"/>
            <end position="772"/>
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        <location>
            <begin position="818"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG7168969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="850" mass="97210" checksum="E634ABBA587FFAC7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5KPG2</accession>
    <name>A0A8J5KPG2_HOMAM</name>
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        <submittedName>
            <fullName evidence="5">F-box/WD repeat-containing protein 2-like</fullName>
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        <name evidence="5" type="primary">Fbxw2-L</name>
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        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Multicrustacea</taxon>
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            <taxon>Eumalacostraca</taxon>
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            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44436">
        <property type="entry name" value="F-BOX/WD REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44436:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
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    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="251"/>
            <end position="292"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
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            <dbReference type="PubMed" id="34162536"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAG7153259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="85" mass="10365" checksum="D302423AE4D7F05D" modified="2022-05-25" version="1">MLQDFISTFKAYYLRQMMRELVQQTEDNRSTIKEFWRNFNINKSWKEVPQQIMNGEWWKIGPSACTSQDSLMWERKVQLDIVNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MJL8</accession>
    <name>A0A8J5MJL8_HOMAM</name>
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            <fullName evidence="1">Putative basic salivary proline-rich protein 2-like 1</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Timp W."/>
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                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7153861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="513" mass="59603" checksum="FE0DC2C14E239E85" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MK31</accession>
    <name>A0A8J5MK31_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G020243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
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        <lineage>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Romanova D.Y."/>
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            </authorList>
            <dbReference type="PubMed" id="34162536"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7154115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="213" mass="23050" checksum="1D67E5DEC1848AD7" modified="2022-05-25" version="1">MGRQAPPVLVVQEALGPQAPSVLVVQEALGPQAPPVLVVQEALGPQAPTVLEVLEAMGPQEVVVPQGLRDSSLLVAPKAVDQLVLEAVDHREALRPVALEVLVVVVLEAMHRLAVSVLPPPPPAHPKCVLDHPVVEVIMVSECTNGNACSWSGEYYPSIFNPQQTLDGYGETAVNITENVAVKDWIFLLEFNVTLGKFWSNSFFNTCCLWHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MLT8</accession>
    <name>A0A8J5MLT8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative vegetative cell wall protein gp1-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G029011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
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        <lineage>
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            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010039226">
        <property type="protein sequence ID" value="KAG7156233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MLT8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7156233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="431" mass="48443" checksum="8AC0214045616405" modified="2022-05-25" version="1" fragment="single">TTRAMTSSPVVCHIGETEALHLTPHSQSFPHSYTSQRVNPSLLHLTGSPSLILHITASPCLTPTHHMSPSHTPTHHSEFLPHTYTSQRVLPSLLHITASPSLTPTPHSESIPHSYTSHQYYKSFPHPTQHIKSIPHSYTTYQVLPSLLHNISSPSLTPRQYCKAIPHSYTTYQVLPSLLYNIPSPSLTLTQHTSPSFTPTQDTKSIPHSYTTYQSIPHSYTTYQVNIPSPLTPTQYYKSFPHSYTTYQVHPSLLHKIVLPSLLHNTTSPSLTPTQDTKSFPHPYTILQVLPSLLHNIPSPSLMPTQYYKSFPHSYTILQVHPSLLHKIPSPSLIPTQYYKSFSYSYTTLQVLPSLLHNTTSTSLTPTQYCKSFPHSYTILQILPSLLHKTTSPSLTPTQHTKSIPHSYTTYQVHHSLLHNTPIPSLTPTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MP97</accession>
    <name>A0A8J5MP97_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G011457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010034478">
        <property type="protein sequence ID" value="KAG7158781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MP97"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7158781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="161" mass="17138" checksum="1210F509698A96C7" modified="2022-05-25" version="1">MWTLALTHHPHLPGTVAMSTPSITQEPLEASGEDNGAASTQQHSQAKLKEGRGGDPSEQGFISSNPLSFSTFSFLPSTGPPGAATYASAATRPTPPRPHAIRPAHPAPHATRPAPPRLTPPRSRHCSTSTCRSSTIKESPRQYDHLTAITPLYEDSHHASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MR61</accession>
    <name>A0A8J5MR61_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G007644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010030594">
        <property type="protein sequence ID" value="KAG7160880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MR61"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7160880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="60" mass="6816" checksum="2B8B952F0C5637C0" modified="2022-05-25" version="1">MKDLKEKEKATKKMVLDPNKTNAAIVKLHDTTEKALEKSKEVQSTQATYFKLNEGLHSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MRG9</accession>
    <name>A0A8J5MRG9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclease HARBI1-like 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Harbi1-L12</name>
        <name evidence="9" type="ORF">Hamer_G016262</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010029607">
        <property type="protein sequence ID" value="KAG7161210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MRG9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="133"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG7161210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="400" mass="44014" checksum="BD0F2C2962F63CD0" modified="2022-05-25" version="1">MESIHLGCPHHQHQDPFTRLTEMEFLNVFRLSKSLVCKLLATLDHRELDDDIPVELQVLATLAFLATGQLSSSARLLGTSRWAAIGIVYKVAQVIKICLGQQYLVFPGDEEQTLFREEFYKISLIPGVLACLDGFAVPLCTISGVEVGWSYITRGHSYLGMVVVCGPQQQIIYIIAQERGSSWPMFNESMLRHSLEEDEVEGMIVVLENFPSKPYLLTPAVPTETVEEYFYNHALKQIMIRSAEKTTHSLKTRFPCLKKGMEPLDPSSLPVLVACAILHNLCLKFSCPLPNYSVTPNLGPDHDLGLDGLDPEDFLDQGHLGPDGNLGLGGYYDPEGHIPPGDLGPEGNIIPGHLGLNYHLGPDGLLGPHGPLGLEGHQIEPYDDFLLNLLTSSGGTPNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MSY6</accession>
    <name>A0A8J5MSY6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G029788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010027805">
        <property type="protein sequence ID" value="KAG7162274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MSY6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7162274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="253" mass="27872" checksum="75475E00441A8EA0" modified="2022-05-25" version="1">MHQHHRPCPQHHPAHRPKYAATVHQHHTWVTVLRLNLAQSAPAPHPPPVPQHHARSARTQLKPTVPQHHTPSHHSAQHHTQPTVHQHHTQPTVPNTHTQPTVHTTPSPQCPNTTPSPRYRHHARPQCQHHPAHGAPAPHTQPTVPQHHPAHSDQHHAHSAPTPHPAHSASTTQPTVPPHHHGPPHTHALPAPPDPQCPNTTATVPQHHTSPQCTKTTPSHSAPTPARYHTQPTVPQHHQCHAPINPSPMANTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MTY4</accession>
    <name>A0A8J5MTY4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DDE superfamily endonuclease domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010026055">
        <property type="protein sequence ID" value="KAG7163928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MTY4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="80"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7163928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="213" mass="24250" checksum="78D3EB61449FE205" modified="2022-05-25" version="1">MLVEATPMITIRELNHTLWQTFPEKPHVCNMIVSRALDGELITLKQLHNVPANRNSEDVKAARLAFVQYMYKDGIHQYRVYVYETGYNLHTCRTYGRALRGQCVNRIVAGQRGSILTLIASISNLARLFYYEIHVTSVTKEVHKKFMTSLDSVLGPKAAVILKDNALCHTGIEQEFEDCVIKKLPAHSPFLNPFENCFSVLKATVKRQLNNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MU78</accession>
    <name>A0A8J5MU78_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Hamer_G019623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010025477">
        <property type="protein sequence ID" value="KAG7164258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MU78"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035287539" evidence="3">
        <location>
            <begin position="24"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7164258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="328" mass="36357" checksum="8ED964FD6C8AB38E" modified="2022-05-25" version="1">MGNKWCAIGLALTVAMGATGAMAVPLVVPGFGRKRRDISRRLAEEEETVRLIHSYQPKVNLYEAFIKGLFNDTNLEPDYEDHDNTTPLEWLYPSEWSAPSDWSAQSAPSDWSAQSDWSAQSAPSDWSAPSPPSPPDIALINPLVPPINLKPLQFVDTAPYPNIFSAASDVEEDQDDEEEADTVKKPPKKKKKKKNESGGCLSSPSCSMAIVMTVVGIAAVGPILSRGRRRREVLEGVGIGQDILQNIDSFSSENYDLPATFSTETDQKRKKTEYMKALLGRLIQMHPSLEQLMHIHTEREANASPYTSINDKYSNSKIKLREISPKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW14</accession>
    <name>A0A8J5MW14_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CUB and sushi domain-containing protein 3-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Csmd3-L2</name>
        <name evidence="10" type="ORF">Hamer_G025249</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010023748">
        <property type="protein sequence ID" value="KAG7165756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW14"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0768">Sushi</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="60"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7165756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="310" mass="33664" checksum="8B0664A6E13A5921" modified="2022-05-25" version="1">MCPELQSALTEALTVKEGDRRVGSSAVYSCGVGRVLVGESTRSCKTHGIWTGTQPRCEWVSCMMPEEIDNGRIVRLNESLLYGAVVEYLCFPKYKLNGPFNRSCTAEGVWSGVAPLCKMDITDYGIFEDNTVDGTSNEARGGPPGSLEEASNTGLYVGLAVGLIAVIVVALLFIFLRTRHQQKGKEREPPVTLKPSESRHNDAMSYADLSDPTTGNNIYENIPEDVEEYGEEYADMSSGSYNNSPAHTYSNGHQPVYSNGMMAPTASLNRPPAHIMRRPRMPPPQPPTVPTTEPPSVVTINGVTLSSQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MW22</accession>
    <name>A0A8J5MW22_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Hamer_G031760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010024233">
        <property type="protein sequence ID" value="KAG7165502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MW22"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035235202" description="Secreted protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7165502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10285" checksum="984ADF90CC64A7EF" modified="2022-05-25" version="1">MMMMMMMMSWVGRACMNCPLRSCCLSSQRTSKETSKRSLTSEESGEEEDKEEKPDHSSQRSHDAFAEQLSKLLRIIILMLVLVKCYQCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MYN7</accession>
    <name>A0A8J5MYN7_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G018455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010021080">
        <property type="protein sequence ID" value="KAG7168019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MYN7"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7168019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="96" mass="10303" checksum="EC14CBA6D4D5CAA7" modified="2022-05-25" version="1">MWCCRALDNHCSLRANRKSQMTHKASVGSWTARPGVARTVAHSLARAMKALNLAPMISVPAGVLKDSCLPPTPGLPPHRRGVTSVASRAPRPLTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5MZW1</accession>
    <name>A0A8J5MZW1_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="5">dUTPase</shortName>
            <ecNumber evidence="5">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Dut-L7</name>
        <name evidence="8" type="ORF">Hamer_G028361</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="5"/>
    <dbReference type="EMBL" id="JAHLQT010015784">
        <property type="protein sequence ID" value="KAG7169581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5MZW1"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="dUTPase-like" evidence="7">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7169581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="389" mass="44791" checksum="D8A47703D2AB0385" modified="2022-05-25" version="1">MPSTVRSVLRFKKLSGNALTPSKGSKLAAGFDLSSAYDIVIAGQGKALIKTDIQVELPEDCYGRVAPRSGLSWKNHIDVGAGVIDRDYRGNVGVVLFNHAKTDFEVKKGDRVAQLICEKIVYPDIEEVEDQFHRDLYAEATETNVEKFIGTADTADKLQENDKFADKQDFAEKFAEKFSQKFVDKFTEKKLEDMDEDKFADNTNKKYWNWRMLFQQPTLLFFLKCFSKQQQQKQQNKCEAWTFWMGYLMGYLFNSVLMSVIITIMIIARSVIKRRSITVNSIKQQQQQQQQQQQNERGGLWTFRDGYMVMGTLFLCVMLVIWVIMVIRRLINRRQDSSPPPPEMPPPSYFELDEMPPPSYFELEIDDQNCCDYNSITSTLMTPPLGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N0W3</accession>
    <name>A0A8J5N0W3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G012450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010013238">
        <property type="protein sequence ID" value="KAG7170884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1478"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1562"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1622"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1353"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1383"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1586"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1631"/>
            <end position="1641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7170884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1659" mass="185109" checksum="8E4205473A7A07F0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N1N3</accession>
    <name>A0A8J5N1N3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G014688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010012015">
        <property type="protein sequence ID" value="KAG7171559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N1N3"/>
    <dbReference type="OrthoDB" id="6382265at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035180284" evidence="1">
        <location>
            <begin position="16"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7171559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="138" mass="15291" checksum="F315527F773DD579" modified="2022-05-25" version="1">MRTLIVVLLAAFVAAEQKREAEPSYGLTNYGHGYRYGHGHSYGYGPVASYHPYGLHSASHSYNHILHKRDAEPSYGLGYGYGHTVGYGHGYGHGYGHGYGFGHGIGKRAAEPSHIYGYSGHGYRPAYGHSYQHRYGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N2H1</accession>
    <name>A0A8J5N2H1_HOMAM</name>
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            <fullName evidence="7">Large ribosomal subunit protein mL45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L45, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mRpL45-L</name>
        <name evidence="11" type="ORF">Hamer_G001107</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
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            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
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                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011632">
        <property type="protein sequence ID" value="KAG7172108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="19619at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000003">
        <property type="entry name" value="39S ribosomal protein L45, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
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            <end position="295"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="346"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00043031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG7172108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="346" mass="39945" checksum="90CF49B5B5CFA217" modified="2022-05-25" version="1">MAARITSQLSKLTLLSSSSSVCLPPLSRSYYVYKDPNYKHFRPNFAFKRKHYIPKFKKARSLKVIKLDLPNLNEKSVEEMTPDEIRAKMKEKGIQPVRPWQEKPVYVASTSGTFEAYVPPEGDGKLSATSKAGAKQKFQFLEKKGKSMIAIRKIRQYDEDFDPKVFAEEAQKIYIETHEALADFDKVRLHQNVTERAYPLVTHQSRQKTIRWQFLGSLAPPHVVHARCTELLNKENVFAQVTVRFHTKQTLAVYDRFGRLQHGSEVVARDVLEYVVFEKHVASSYGTWRIHDKIIPDWMPPRQPILKTYRFEDIEPEVKTTPDDKESKEVEVATVTQNQSASPAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N384</accession>
    <name>A0A8J5N384_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Filamentous hemagglutinin-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fhaB-L5</name>
        <name evidence="2" type="ORF">Hamer_G022015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010011483">
        <property type="protein sequence ID" value="KAG7172373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N384"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7172373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="1110" mass="122365" checksum="B3B4C423723C02F2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N611</accession>
    <name>A0A8J5N611_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G003105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N611"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="117" mass="13129" checksum="15C84BE07600CD86" modified="2022-05-25" version="1">MTPGVGYGTAIHPVEEPPTFATPTVKKYKIPKETEFNHAYEVVVALELEYKNIKFSVKPNLVGDLILPPPSPQDHNTAKILREVTNLNGKTVKIIPLDPEEKTTRMVLLRYPLELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6J9</accession>
    <name>A0A8J5N6J9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G022344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008102">
        <property type="protein sequence ID" value="KAG7174024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6J9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7174024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="162" mass="17331" checksum="0447FED0EB0D9B53" modified="2022-05-25" version="1">MALTSVSVHTCWSLHTCCPFLHSLYIVSPQTEVPPHAVDKDAHTDHYSSPAHNKQLVYGTCPTSTTSLTLLTTRPHPFTTRLGPSTTCLGSALRQILTATPHMRPHPPLPVTPLLPVTPPLPVTPLFPLTPPCPSTLSSAHASDLRLSQTHTNSCGGNPSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N6T6</accession>
    <name>A0A8J5N6T6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative crustin-like antimicrobial peptide 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">crustin-L1</name>
        <name evidence="3" type="ORF">Hamer_G003092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007678">
        <property type="protein sequence ID" value="KAG7174190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N6T6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035158192" evidence="1">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="2">
        <location>
            <begin position="56"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG7174190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="113" mass="12694" checksum="FCC9BFD82E1B68F1" modified="2022-05-25" version="1">MMKLWLVVCVVGGWQVSLGAGQLPCLADPIQPDCVAFCPNNYNGEYFCCDTNGNNPGQCPKYSLTADERSLLCDPTQHNYPYHLNCKSDTDCFAWEKCCYLPQNNQRICRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N799</accession>
    <name>A0A8J5N799_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pogo transposable element-like 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Pogo-L14</name>
        <name evidence="4" type="ORF">Hamer_G026681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010008527">
        <property type="protein sequence ID" value="KAG7173933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N799"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018586">
        <property type="entry name" value="Brinker_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09607">
        <property type="entry name" value="BrkDBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="TrpR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="65"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7173933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="174" mass="20518" checksum="D1BE88E33123370D" modified="2022-05-25" version="1" fragment="single">TCLTHILFSMDSRRKFTAMFKLRVIEYAEQTNNCAAAREFKVSEKSVRDWKMFSAQLKLLPKNKCANRGKCNKWPQLEVEVAKYVSENRQNGYGVSRGSIRIFALKLARKLGITDFKASHGWCTRFMERNDFVLRRKTKISQRLPQELDDKIRIRKTCNYDIRIHKVKDSDIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N7W3</accession>
    <name>A0A8J5N7W3_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CLIP domain-containing serine protease</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Pce-L10</name>
        <name evidence="12" type="ORF">Hamer_G015805</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="JAHLQT010007499">
        <property type="protein sequence ID" value="KAG7174669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N7W3"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Clip" evidence="11">
        <location>
            <begin position="118"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="206"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG7174669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="464" mass="50722" checksum="4D771E79C2814254" modified="2022-05-25" version="1">MVVVLSFETEKLLSKEMSGNTKRAAPRLPGWSTWGSEGPKEQLLAARLQWRYKYLLSWVSLPLSYNYKGTMKWLGGILLLLVTVNGQLSDNQTGEALSGLLAEKVAERQNFNLGGDDSCFTPDNEPGRCGPLTDCPVYLPLARQLQQQDIINFFTSRICRLLFRTVHVCCPTNPNPLMPGGSIQISPRPTTSININDCGIPSGDRVIGGTEVEYPGKWPWLAALGIRRFGRFIPTCGGTLITSRHVLSAAHCFKDKQQSPLGEHSLSKTDEGANPQDFSIVEQRNNGYNSKTQENDIIILVLDREVQFSFITQVNVSDTSQPLTVASISSPALVVPACLPYNEVNNEFEGQSLTVVGWGTTSTSPRTDVPMEADVSIVPRSQCVTAYLNTQDRPVVDERQLCAGEGTRDSCSGDSGGPLNHRGPGGRYTVAGIVSFGVGCARAEFPGVYTRVSSFLDWIEKNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N838</accession>
    <name>A0A8J5N838_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nicotinic acetylcholine receptor alpha 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Hamer_G022725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010005387">
        <property type="protein sequence ID" value="KAG7175595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N838"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7175595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="203" mass="23642" checksum="3C14FCE478BE4AC6" modified="2022-05-25" version="1">MRGREVPSFVKKVVFSYMAKMMCIRLDIPDPMGGQGHKFTNMNHQGEGYPGYREFGPSHLEMSDRLLDPEVKCENGGIPPSRLTGGVHSQHSTSCPAAHPCLDTFERHFIRVLNKVYQTIEKNEIRLAEQDRRDTIKLEWQQVALIPLVDFHHRYHQLHFWHHVYVTAHQALHHVVRHSPVHHQDTSPYSEVFQPIIKLFPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8M0</accession>
    <name>A0A8J5N8M0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G023979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010007069">
        <property type="protein sequence ID" value="KAG7174743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8M0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7174743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="788" mass="84807" checksum="556A31125760C710" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5N8Y9</accession>
    <name>A0A8J5N8Y9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tigger transposable element-derived protein 7-like 71</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIGD7-L71</name>
        <name evidence="5" type="ORF">Hamer_G026225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010004030">
        <property type="protein sequence ID" value="KAG7176150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5N8Y9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="142"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG7176150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="309" mass="34460" checksum="A75287680A67ADE5" modified="2022-05-25" version="1">MRAGQRQWLGQELKQVRGSGWDKGNESGQRQWLGQVMRAVRGSDWDKGNVSGSEAVAGTRGEQYAKEDVCDPFCEPETGTYKEVRGWCFSDEYGVKKQTVSDISKAQDKLTVFSLKYNVDANFKSSSVGARKHRRVAKDTNLEEAVTKWFVQQRSCGNVVRGVEIQAAAAKLASHMGIENFEASDAFKNEDEEDDEPLPKKPKLSVIRESIDNVILYIELSAETDDVQHYYQHIRAFRELIIQKQHQQGKQLKLDSFFKPVHPNPAAAVKPADDIDDPPAADSGHPQSPQPSTSGGQGPVEHHSSTDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAH9</accession>
    <name>A0A8J5NAH9_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cullin-3-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Cul3a-L</name>
        <name evidence="8" type="ORF">Hamer_G000189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAH9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000005">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000006">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="389"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="609"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="609"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7176975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="826" mass="94216" checksum="F8BA39020BA7486E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAM9</accession>
    <name>A0A8J5NAM9_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="3 13">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Kars-L</name>
        <name evidence="16" type="ORF">Hamer_G000292</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3 13"/>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAM9"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="287"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7177066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="637" mass="72867" checksum="3288C9BFA497E24C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NAT4</accession>
    <name>A0A8J5NAT4_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Guanine nucleotide-binding protein subunit alpha-13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Gna13-L</name>
        <name evidence="16" type="ORF">Hamer_G000439</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-alpha family. G(12) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NAT4"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031752">
        <property type="term" value="F:D5 dopamine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000754">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000469">
        <property type="entry name" value="Gprotein_alpha_12/13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00440">
        <property type="entry name" value="GPROTEINA12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="37"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="170"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="264"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG7177186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="353" mass="41286" checksum="621CA9DEA9968F33" modified="2022-05-25" version="1">MVTGGNMARVTMLSCACCLRALWTPEEVKLLLLGAGESGKSTFLKQMRIIHGYRFAHDEIDEYRETIYKNVVLGMKVLLDARDKLRIPWGDESREIYGQHVMKFVGSMLLDRLLFLDYVPSVKELWKDTGIRQAYNRRAEYQLTDSVAYFFDCLDRIGVLEYMPTEKDILHCRKATKAITEFTIPIQNVPFLFVDVGGQRTQRQKWFQCFESVTSIIFLASSSEFDQRLLEDRITNRLEESLNIFGTIVNNRNFREVSIILFLNKTDLLVQKIRSRQSNVSHYFTDFVGNPHDEKCVQQFILHKFVEQRRADNNRRPIFHHFTTAVDTENIKVVFNSVKDTILQRNLETLMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NB02</accession>
    <name>A0A8J5NB02_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Origin recognition complex subunit 4-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Orc4-L2</name>
        <name evidence="1" type="ORF">Hamer_G030613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010003595">
        <property type="protein sequence ID" value="KAG7176214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NB02"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG7176214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="121" mass="13320" checksum="B05F1472F5305E5F" modified="2022-05-25" version="1" fragment="single">MTRTLTLGESNSALLVNTVIEKLEASGTLGEGVVVRLSGLLQTDDRLALKEITCQLKLENATANKVFGSFAENLAFLLESLRCGSKETSKPVIFILDEFDLFCHHRNQTLLYNLFDVAQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NB05</accession>
    <name>A0A8J5NB05_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G000640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7177321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NB05"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="156" mass="16882" checksum="AB2F0AF796812540" modified="2022-05-25" version="1">MAAADEYSTTSHVLQLCLALQDRLEKVEKEVQSLKGENLVLKLGLEEKKTFASVVKDGEVEVDSWKVVAASATKCTLKRHSAVDLNNRFSTLSDECEEGASNTTSATPSVSVERGSSAGPCGSSRDHRFMNLCMCALSAADMWMNCAFDVPMAKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NCA8</accession>
    <name>A0A8J5NCA8_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain-containing protein 50-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Ankrd50-L1</name>
        <name evidence="6" type="ORF">Hamer_G000139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010002534">
        <property type="protein sequence ID" value="KAG7176933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NCA8"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03716">
        <property type="entry name" value="SOCS_ASB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="391"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="424"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="457"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="490"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="5">
        <location>
            <begin position="667"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG7176933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="725" mass="79619" checksum="038478E2518C2A67" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5NDQ6</accession>
    <name>A0A8J5NDQ6_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Hamer_G030179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010001735">
        <property type="protein sequence ID" value="KAG7177803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5NDQ6"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG7177803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="174" mass="18725" checksum="180FEB3A67D77AA8" modified="2022-05-25" version="1" fragment="single">CSRGTTTSCSMPLSPTSATPVRSWRPRFFLQKDGQDTRDVRTPEGGQGHRTGASGPSSPGDRGVTLEWCCQDGGHRPAADPSLAPSTTLAALKKLRRRPTSDPCSTSSLAKQSRRVSPLLSCRGGLLGRREPSSTMPLTRHDDLRVAGEVQQHEELVSRSWRQLLITALGAPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T3L5</accession>
    <name>A0A8J5T3L5_HOMAM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Chst11-L6</name>
        <name evidence="10" type="ORF">Hamer_G009599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="JAHLQT010011563">
        <property type="protein sequence ID" value="KAG7172246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T3L5"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG7172246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="347" mass="40971" checksum="A736FF7F44E6441C" modified="2022-05-25" version="1">MPRPSYARARAKRYPPTKWGKVTLWAFILLAVSTFTIITTSGIDYQRISGLNWILNQDKSQSENVQFQQDYPANMEWEEVQQRRVQHMLHACSSLNLNQTLDYMVLKHLLVDTRHKTLMCFVPKVACTSWKRLWFWMVGLLQDDDDIMDLTRAQVHGPLLPNLANTMFPEAKKEEILRTYKKFLFTRHPLDRLISAFSDKLENSDRESKFDFHKYVGQEVEMMVRGKVTGLGHNVTFPEFIKWVTPPNGTWTEAQKNEHWRPISELCAPCTVQYNAVGRYENLEQEMNATLHWLDVGHYARRFPPPDRTFHAAERRHQYLQHLASDDKLRFLRTYLLDFLLFGYDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T3N0</accession>
    <name>A0A8J5T3N0_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multiple epidermal growth factor-like domains protein 6-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Megf6-L3</name>
        <name evidence="8" type="ORF">Hamer_G006814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010484">
        <property type="protein sequence ID" value="KAG7172604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T3N0"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000037">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000041">
        <property type="entry name" value="Tyrosine protein kinase receptor tie-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052108">
        <property type="entry name" value="MEGF/SIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035:SF109">
        <property type="entry name" value="PROTEIN DRAPER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG7172604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="413" mass="44661" checksum="563B46320F8E0733" modified="2022-05-25" version="1">MEVINSCLENNGGCQHMCRHGPGGAVCTCHPGYLLQPDRRTCQDEDECEARTHRCQQECVNTAGGYACACTQGYILSSDTFTCVDVDECERENGGCEHECRNTQGSFVCSCRSGYNLIDFNHCEIVDYQYTDDYLGQSSRGDLDLGTALEDDFTVPEDTSAKTRDTWEDITYAEYSKFHTVHTRCVPGHFGPNCSLTCADCPGQCDTSGCLCTPGRTGPTCSLTCPPGFYGTGCNEVCRCENDGTCDPMTGNCTCPPGVSGDLCEDGCPAGYYGSKCERRCPMMCPNMRCNRVFGFCECDPGRFGPKCNMPCPALTWGPNCRHQCQCQARTTARCHAESGVCECSPGYVGSDCSQECLPGRWGAGCLHECQCASGATCHPATGVCFQDCPPGFTGSDCTIRKLANSLYLIVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T7H3</accession>
    <name>A0A8J5T7H3_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Doublesex-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dsx-L</name>
        <name evidence="4" type="ORF">Hamer_G008713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010010178">
        <property type="protein sequence ID" value="KAG7173176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T7H3"/>
    <dbReference type="OrthoDB" id="5842031at2759"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF53">
        <property type="entry name" value="DOUBLESEX-MAB RELATED 11E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="3">
        <location>
            <begin position="154"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="1">
        <location>
            <begin position="154"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG7173176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000747542"/>
        </source>
    </evidence>
    <sequence length="296" mass="31961" checksum="72D93C55ED877B29" modified="2022-05-25" version="1">MAMAPKKKIDFFNGGRGVDRNEPFCEQDPRRQLARPEVVPESYGYGGDCGRYPPSSPGGYMPPNSPSVHQYHSDYPHPSSPTGQQYHSDFHHPTTSRSQSPTAYDIGQEGYTSSGGYPPNSPSDFGGSSGVDGTAGPSSPADNDSRKKKRKQQCRLCANHGAYVQVKGHKWYCPYRENHTCEKCTITKKRQFYMAEQQKLTREQQQTAQRGGTLGGCGIVGGSGGGSGGGVVGGGASEAPCNIPSGVPMETTQAPRQTGAPTDFPRLAELVRETSNIINEDFFAMIDKVVRPKAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J5T941</accession>
    <name>A0A8J5T941_HOMAM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Eva-1 C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Eva1c-L</name>
        <name evidence="4" type="ORF">Hamer_G024031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Homarus americanus</name>
        <name type="common">American lobster</name>
        <dbReference type="NCBI Taxonomy" id="6706"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Multicrustacea</taxon>
            <taxon>Malacostraca</taxon>
            <taxon>Eumalacostraca</taxon>
            <taxon>Eucarida</taxon>
            <taxon>Decapoda</taxon>
            <taxon>Pleocyemata</taxon>
            <taxon>Astacidea</taxon>
            <taxon>Nephropoidea</taxon>
            <taxon>Nephropidae</taxon>
            <taxon>Homarus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>The American lobster genome reveals insights on longevity, neural, and immune adaptations.</title>
            <authorList>
                <person name="Polinski J.M."/>
                <person name="Zimin A.V."/>
                <person name="Clark K.F."/>
                <person name="Kohn A.B."/>
                <person name="Sadowski N."/>
                <person name="Timp W."/>
                <person name="Ptitsyn A."/>
                <person name="Khanna P."/>
                <person name="Romanova D.Y."/>
                <person name="Williams P."/>
                <person name="Greenwood S.J."/>
                <person name="Moroz L.L."/>
                <person name="Walt D.R."/>
                <person name="Bodnar A.G."/>
            </authorList>
            <dbReference type="PubMed" id="34162536"/>
            <dbReference type="DOI" id="10.1126/sciadv.abe8290"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GMGI-L3</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAHLQT010009989">
        <property type="protein sequence ID" value="KAG7173340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J5T941"/>
    <dbReference type="Proteomes" id="UP000747542">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22828">
        <property type="entry name" value="Gal_Rha_Lectin_EVA1_EVA1C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22829">
        <property type="entry name" value="Gal_Rha_Lectin_EVA1_EVA1C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46780">
        <property type="entry name" value="PROTEIN EVA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="3">
        <location>
            <begin position="38"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="3">
        <location>
            <begin position="160"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues